cilnidipine Indications/Contra | FAERs | Orange Book | BioActivity |

Stem definitionDrug idCAS RN
calcium channel blockers, nifedipine derivatives 642 132203-70-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • FRC-8653
  • cilnidipine
  • cinaldipine
  • cinalong
has excitatory & inhibitory action on the Ca+ channels in the rabbit basilar artery; structure given in first source; RN given is for (+-) isomer
  • Molecular weight: 492.53
  • Formula: C27H28N2O7
  • CLOGP: 5.54
  • LIPINSKI: 1
  • HAC: 9
  • HDO: 1
  • TPSA: 117
  • ALOGS: -5.94
  • ROTB: 12

Drug dosage:

DoseUnitRoute
10 mg O

Approvals:

None

FDA Adverse Event Reporting System

None

Pharmacologic Action:

SourceCodeDescription
ATC C08CA14 CARDIOVASCULAR SYSTEM
CALCIUM CHANNEL BLOCKERS
SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS
Dihydropyridine derivatives
MeSH PA D002121 Calcium Channel Blockers
MeSH PA D000077264 Calcium-Regulating Hormones and Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D049990 Membrane Transport Modulators
CHEBI has role CHEBI:35674 antihypertensive agent
CHEBI has role CHEBI:35554 cardiovascular drug

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 2.67 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Voltage-gated L-type calcium channel Ion channel BLOCKER SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE
Voltage-dependent N-type calcium channel subunit alpha-1B Unclassified BLOCKER IC50 6.70 IUPHAR

External reference:

IDSource
D01173 KEGG_DRUG
010899 NDDF
97T5AZ1JIP UNII
6880 INN_ID
CHEMBL452076 ChEMBL_ID
DB09232 DRUGBANK_ID
CHEBI:31399 CHEBI
7767 IUPHAR_LIGAND_ID
C065927 MESH_SUPPLEMENTAL_RECORD_UI
5282138 PUBCHEM_CID

Pharmaceutical products:

None