felodipine ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
calcium channel blockers, nifedipine derivatives 1142 72509-76-3

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • felodipine
  • (RS)-Felodipine
  • (+/-)-Felodipine
  • flodil
  • dl-Felodipine
A dihydropyridine calcium antagonist with positive inotropic effects. It lowers blood pressure by reducing peripheral vascular resistance through a highly selective action on smooth muscle in arteriolar resistance vessels.
  • Molecular weight: 384.25
  • Formula: C18H19Cl2NO4
  • CLOGP: 5.30
  • LIPINSKI: 1
  • HAC: 5
  • HDO: 1
  • TPSA: 64.63
  • ALOGS: -4.73
  • ROTB: 6

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
5 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 2 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.00 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 0.25 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.87 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 15 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 4.40 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 11 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.00 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 10 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
July 25, 1991 FDA ASTRAZENECA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cardiospasm 195.02 15.74 52 15077 1855 63472038
Palmoplantar keratoderma 192.39 15.74 52 15077 1955 63471938
Pruritus genital 178.01 15.74 52 15077 2602 63471291
Sleep terror 177.51 15.74 52 15077 2628 63471265
Atrial tachycardia 154.03 15.74 52 15077 4188 63469705
Carotid artery occlusion 152.70 15.74 53 15076 4641 63469252
Tension headache 151.30 15.74 54 15075 5132 63468761
Vasculitis 134.74 15.74 72 15057 18137 63455756
Anosmia 133.10 15.74 53 15076 6807 63467086
Muscle twitching 126.81 15.74 71 15058 19597 63454296
Tinnitus 126.48 15.74 88 15041 35540 63438353
Immunisation 119.47 15.74 32 15097 1161 63472732
Pain of skin 115.18 15.74 56 15073 11578 63462315
Facial pain 111.11 15.74 53 15076 10508 63463385
Lip swelling 101.62 15.74 73 15056 30990 63442903
Ventricular tachycardia 99.44 15.74 61 15068 19918 63453975
Hallucination 98.91 15.74 91 15038 54726 63419167
Subarachnoid haemorrhage 98.75 15.74 54 15075 14229 63459664
Angioedema 93.16 15.74 83 15046 47882 63426011
Eye pruritus 87.84 15.74 55 15074 18616 63455277
Blindness 82.67 15.74 56 15073 21643 63452250
Blood creatine increased 77.45 15.74 34 15095 5567 63468326
Diplopia 75.86 15.74 55 15074 23673 63450220
Hyponatraemia 69.95 15.74 108 15021 111792 63362101
Transient ischaemic attack 68.71 15.74 63 15066 37690 63436203
Palpitations 65.18 15.74 105 15024 112665 63361228
Hypopnoea 62.18 15.74 26 15103 3780 63470113
Drug ineffective 59.42 15.74 99 15030 1044666 62429227
Disturbance in attention 58.60 15.74 58 15071 38131 63435762
Catarrh 56.26 15.74 19 15110 1530 63472363
Intentional product misuse 54.75 15.74 70 15059 60847 63413046
Steroid dependence 53.84 15.74 19 15110 1745 63472148
Swollen tongue 51.82 15.74 52 15077 34748 63439145
Burns second degree 51.72 15.74 19 15110 1959 63471934
Dizziness 51.05 15.74 220 14909 429705 63044188
Rash papular 49.28 15.74 36 15093 15666 63458227
Tachycardia 48.84 15.74 95 15034 118061 63355832
Accidental overdose 48.57 15.74 42 15087 23267 63450626
Dehydration 48.42 15.74 119 15010 173235 63300658
Drug interaction 47.62 15.74 141 14988 228990 63244903
Bradycardia 46.18 15.74 71 15058 73156 63400737
Amnesia 43.96 15.74 60 15069 55525 63418368
Rectal haemorrhage 43.51 15.74 56 15073 48974 63424919
Nightmare 42.88 15.74 36 15093 19158 63454735
Drug intolerance 41.78 15.74 11 15118 308650 63165243
Arthropathy 41.49 15.74 4 15125 234788 63239105
Dry skin 41.40 15.74 59 15070 56828 63417065
Migraine 41.37 15.74 82 15047 103264 63370629
Infusion related reaction 41.30 15.74 5 15124 245516 63228377
Visual impairment 41.28 15.74 73 15056 84373 63389520
Maternal exposure during pregnancy 40.94 15.74 3 15126 220059 63253834
Confusional state 40.42 15.74 136 14993 236244 63237649
Serotonin syndrome 39.33 15.74 41 15088 28641 63445252
Dopamine transporter scintigraphy abnormal 38.97 15.74 8 15121 87 63473806
Cognitive disorder 37.86 15.74 56 15073 55759 63418134
Contraindicated product administered 37.69 15.74 4 15125 217644 63256249
Hyperhidrosis 36.65 15.74 80 15049 107756 63366137
Blood glucose increased 36.63 15.74 69 15060 83687 63390206
COVID-19 34.08 15.74 80 15049 113023 63360870
Acute kidney injury 32.88 15.74 137 14992 263278 63210615
Myocardial infarction 32.69 15.74 73 15056 99820 63374073
Medication error 31.99 15.74 50 15079 52234 63421659
Tubulointerstitial nephritis 31.96 15.74 31 15098 19872 63454021
Frequent bowel movements 31.72 15.74 33 15096 22989 63450904
Therapeutic product effect decreased 29.99 15.74 5 15124 193182 63280711
Spider naevus 29.23 15.74 7 15122 160 63473733
Memory impairment 28.47 15.74 71 15058 104187 63369706
Colitis ulcerative 28.32 15.74 33 15096 26058 63447835
Product use issue 27.73 15.74 9 15120 220511 63253382
Infection 27.70 15.74 10 15119 229163 63244730
Discomfort 26.73 15.74 4 15125 167370 63306523
Hyperreflexia 26.70 15.74 17 15112 5917 63467976
Gingival pain 26.26 15.74 19 15110 8143 63465750
Parosmia 26 15.74 17 15112 6189 63467704
Wound 25.85 15.74 4 15125 163259 63310634
Heart rate increased 25.54 15.74 64 15065 94174 63379719
Polyuria 25.49 15.74 19 15110 8523 63465370
Hyperkalaemia 25.38 15.74 46 15083 54157 63419736
Clonus 25.24 15.74 15 15114 4621 63469272
IIIrd nerve paresis 24.90 15.74 6 15123 141 63473752
Retinal detachment 24.15 15.74 16 15113 5953 63467940
Cardiac murmur 24.00 15.74 23 15106 14529 63459364
Treatment failure 23.52 15.74 9 15120 199034 63274859
Capillary disorder 22.68 15.74 5 15124 78 63473815
Gingival hypertrophy 22.64 15.74 10 15119 1661 63472232
Hepatic enzyme increased 22.53 15.74 10 15119 202318 63271575
Muscular weakness 22.31 15.74 72 15057 122281 63351612
Nodal rhythm 22.23 15.74 10 15119 1733 63472160
Rheumatoid arthritis 21.97 15.74 17 15112 253802 63220091
Injection site pain 20.96 15.74 3 15126 129797 63344096
Swelling 20.76 15.74 21 15108 275357 63198536
Rhinitis 20.73 15.74 19 15110 11347 63462546
Chest pain 20.72 15.74 104 15025 215855 63258038
Ultrasound kidney abnormal 20.37 15.74 4 15125 34 63473859
Multiple organ dysfunction syndrome 20.29 15.74 43 15086 56709 63417184
Bronchiectasis 20.22 15.74 22 15107 16120 63457773
Therapeutic product effect incomplete 19.94 15.74 3 15126 125053 63348840
Eczema 19.91 15.74 31 15098 32260 63441633
Neonatal anuria 18.97 15.74 4 15125 50 63473843
Iodine allergy 18.38 15.74 7 15122 797 63473096
Death 18.03 15.74 39 15090 374342 63099551
Pupillary reflex impaired 17.73 15.74 9 15120 2038 63471855
Impaired quality of life 17.64 15.74 19 15110 13764 63460129
Sinusitis 17.40 15.74 17 15112 226636 63247257
Hypomagnesaemia 16.90 15.74 27 15102 28710 63445183
Sinus bradycardia 16.80 15.74 19 15110 14532 63459361
Product dose omission issue 16.40 15.74 19 15110 234294 63239599
Transient global amnesia 15.96 15.74 6 15123 659 63473234
Malaise 15.86 15.74 160 14969 415794 63058099
Glomerulonephritis 15.81 15.74 8 15121 1798 63472095

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cardiospasm 228.87 14.92 66 16830 1522 34938513
Palmoplantar keratoderma 211.15 14.92 65 16831 1888 34938147
Tension headache 205.90 14.92 71 16825 2971 34937064
Pruritus genital 199.30 14.92 64 16832 2140 34937895
Sleep terror 196.13 14.92 64 16832 2254 34937781
Facial pain 177.61 14.92 67 16829 3637 34936398
Atrial tachycardia 175.02 14.92 66 16830 3579 34936456
Carotid artery occlusion 173.42 14.92 66 16830 3671 34936364
Anosmia 172.21 14.92 67 16829 3957 34936078
Lip swelling 160.93 14.92 99 16797 15981 34924054
Immunisation 156.26 14.92 45 16851 1032 34939003
Angioedema 155.00 14.92 135 16761 37239 34902796
Eye pruritus 138.14 14.92 69 16827 7420 34932615
Pain of skin 135.94 14.92 64 16832 6045 34933990
Vasculitis 119.30 14.92 72 16824 11224 34928811
Pericarditis 114.73 14.92 71 16825 11574 34928461
Subarachnoid haemorrhage 114.36 14.92 73 16823 12562 34927473
Migraine 112.98 14.92 82 16814 17396 34922639
Tinnitus 111.36 14.92 86 16810 20032 34920003
Muscle twitching 109.68 14.92 66 16830 10232 34929803
Rash papular 102.10 14.92 63 16833 10215 34929820
Blindness 93.88 14.92 69 16827 14917 34925118
Palpitations 87.21 14.92 102 16794 39884 34900151
Dry skin 85.82 14.92 90 16806 31197 34908838
Diplopia 82.47 14.92 67 16829 16776 34923259
Transient ischaemic attack 80.36 14.92 82 16814 27531 34912504
Alopecia 75.78 14.92 75 16821 24280 34915755
Death 72.95 14.92 52 16844 397997 34542038
Visual impairment 67.73 14.92 85 16811 35717 34904318
Disturbance in attention 64.74 14.92 71 16825 25874 34914161
Ventricular tachycardia 63.33 14.92 71 16825 26508 34913527
Drug ineffective 63.28 14.92 77 16819 456674 34483361
Amnesia 61.66 14.92 70 16826 26493 34913542
Dizziness 61.50 14.92 238 16658 218283 34721752
Cognitive disorder 58.91 14.92 71 16825 28622 34911413
Muscular weakness 58.85 14.92 117 16779 72780 34867255
Chest pain 51.33 14.92 156 16740 126606 34813429
Myocardial infarction 49.01 14.92 149 16747 120936 34819099
Blood glucose increased 47.85 14.92 102 16794 66616 34873419
Abdominal discomfort 47.04 14.92 95 16801 59740 34880295
Memory impairment 45.62 14.92 78 16818 43240 34896795
Hallucination 44.39 14.92 85 16811 51413 34888622
Heart rate increased 44.34 14.92 80 16816 46263 34893772
Peripheral swelling 43.78 14.92 107 16789 76434 34863601
Feeling abnormal 42.29 14.92 94 16802 63141 34876894
Nail bed bleeding 38.25 14.92 12 16884 371 34939664
Hyperhidrosis 35.26 14.92 98 16798 75594 34864441
Intentional product misuse 31.84 14.92 69 16827 45542 34894493
Completed suicide 31.25 14.92 5 16891 98163 34841872
Gingival pain 31.04 14.92 19 16877 3033 34937002
Tubulointerstitial nephritis 30.68 14.92 44 16852 20980 34919055
Product dose omission issue 30.37 14.92 10 16886 119701 34820334
COVID-19 29.09 14.92 93 16803 77457 34862578
Febrile neutropenia 28.97 14.92 15 16881 136834 34803201
Adverse drug reaction 28.49 14.92 51 16845 29291 34910744
Abdominal pain upper 27.97 14.92 87 16809 71403 34868632
Burns second degree 25.64 14.92 12 16884 1117 34938918
Tachycardia 25.11 14.92 94 16802 84678 34855357
Catarrh 23.84 14.92 11 16885 991 34939044
Orthostatic hypotension 23.83 14.92 44 16852 25875 34914160
Swollen tongue 23.44 14.92 32 16864 14573 34925462
Daydreaming 22.81 14.92 9 16887 551 34939484
Steroid dependence 22.28 14.92 12 16884 1505 34938530
Oedema 22.05 14.92 60 16836 45681 34894354
Insomnia 22.01 14.92 104 16792 103803 34836232
Syncope 21.96 14.92 95 16801 91356 34848679
International normalised ratio increased 21.75 14.92 61 16835 47266 34892769
Liver function test abnormal 21.67 14.92 47 16849 31027 34909008
Pleuritic pain 21.48 14.92 16 16880 3525 34936510
Off label use 21.10 14.92 118 16778 419406 34520629
Intentional product use issue 20.86 14.92 70 16826 59746 34880289
Dehydration 20.58 14.92 120 16776 129849 34810186
Scrotal oedema 20.20 14.92 12 16884 1814 34938221
Anxiety 19.96 14.92 98 16798 99330 34840705
Sleep inertia 18.92 14.92 4 16892 23 34940012
Disease progression 18.56 14.92 15 16881 108062 34831973
Septic shock 18.21 14.92 6 16890 71828 34868207
Hypopnoea 17.72 14.92 12 16884 2277 34937758
Pneumonia 17.67 14.92 103 16793 362524 34577511
Atrioventricular block first degree 17.54 14.92 18 16878 6074 34933961
Pruritus 17.49 14.92 123 16773 141858 34798177
Parosmia 17.09 14.92 12 16884 2413 34937622
Bradycardia 17.08 14.92 77 16819 75341 34864694
Drug abuse 16.71 14.92 14 16882 99082 34840953
Pain 16.45 14.92 161 16735 204514 34735521
Leukopenia 16.38 14.92 5 16891 62851 34877184
Swelling face 16.17 14.92 35 16861 23070 34916965
Faeces discoloured 15.92 14.92 27 16869 14851 34925184
Interstitial lung disease 15.61 14.92 6 16890 65276 34874759
Dyspnoea 15.60 14.92 262 16634 376520 34563515
External ear pain 15.08 14.92 3 16893 12 34940023

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Cardiospasm 410.82 14.58 115 28951 3186 79712136
Palmoplantar keratoderma 392.91 14.58 114 28952 3602 79711720
Sleep terror 368.18 14.58 113 28953 4345 79710977
Pruritus genital 367.48 14.58 113 28953 4373 79710949
Tension headache 349.07 14.58 122 28944 7089 79708233
Atrial tachycardia 323.61 14.58 115 28951 7018 79708304
Carotid artery occlusion 319.52 14.58 116 28950 7531 79707791
Anosmia 303.08 14.58 116 28950 8728 79706594
Immunisation 267.39 14.58 75 28991 2092 79713230
Facial pain 262.37 14.58 115 28951 12235 79703087
Lip swelling 251.76 14.58 167 28899 40744 79674578
Vasculitis 248.63 14.58 139 28927 24963 79690359
Angioedema 247.65 14.58 212 28854 75823 79639499
Pain of skin 246.93 14.58 116 28950 14497 79700825
Muscle twitching 236.79 14.58 134 28932 24630 79690692
Tinnitus 227.96 14.58 162 28904 44171 79671151
Eye pruritus 220.47 14.58 120 28946 20450 79694872
Subarachnoid haemorrhage 208.92 14.58 123 28943 24342 79690980
Blindness 182.22 14.58 119 28947 28264 79687058
Diplopia 159.91 14.58 117 28949 33349 79681973
Ventricular tachycardia 159.53 14.58 128 28938 41807 79673515
Transient ischaemic attack 155.56 14.58 139 28927 52556 79662766
Hallucination 149.51 14.58 170 28896 85575 79629747
Rash papular 145.86 14.58 94 28972 21822 79693500
Disturbance in attention 130.51 14.58 124 28942 50677 79664645
Dry skin 129.16 14.58 141 28925 67854 79647468
Migraine 127.01 14.58 158 28908 87335 79627987
Palpitations 123.97 14.58 189 28877 126421 79588901
Amnesia 113.27 14.58 127 28939 62930 79652392
Drug ineffective 106.13 14.58 144 28922 1080769 78634553
Visual impairment 103.85 14.58 147 28919 91984 79623338
Blood glucose increased 97.85 14.58 161 28905 114814 79600508
Dizziness 93.25 14.58 409 28657 526032 79189290
Cognitive disorder 93.12 14.58 121 28945 69805 79645517
Myocardial infarction 89.12 14.58 203 28863 183926 79531396
Muscular weakness 82.02 14.58 181 28885 160548 79554774
Intentional product misuse 81.96 14.58 134 28932 95031 79620291
Memory impairment 72.53 14.58 139 28927 111595 79603727
Dehydration 71.71 14.58 226 28840 247961 79467361
Hyperhidrosis 69.95 14.58 164 28902 151328 79563994
Heart rate increased 66.20 14.58 140 28926 120584 79594738
Tachycardia 65.88 14.58 177 28889 177591 79537731
COVID-19 65.64 14.58 164 28902 157510 79557812
Catarrh 65.52 14.58 26 29040 2152 79713170
Hypopnoea 65.28 14.58 34 29032 5295 79710027
Chest pain 64.79 14.58 238 28828 282066 79433256
Burns second degree 64.12 14.58 27 29039 2601 79712721
Steroid dependence 64.10 14.58 27 29039 2603 79712719
Hyponatraemia 61.85 14.58 173 28893 177675 79537647
Swollen tongue 60.33 14.58 76 28990 42494 79672828
Bradycardia 59.60 14.58 144 28922 135413 79579909
Death 57.89 14.58 73 28993 566441 79148881
Pericarditis 57.28 14.58 121 28945 104115 79611207
Blood creatine increased 54.29 14.58 37 29029 9418 79705904
Tubulointerstitial nephritis 53.77 14.58 68 28998 38167 79677155
Feeling abnormal 53.52 14.58 153 28913 159046 79556276
Accidental overdose 53.46 14.58 69 28997 39512 79675810
Infusion related reaction 50.66 14.58 11 29055 230226 79485096
Gingival pain 48.81 14.58 34 29032 8964 79706358
Nightmare 47.98 14.58 53 29013 25808 79689514
Drug intolerance 46.54 14.58 19 29047 264100 79451222
Rectal haemorrhage 43.57 14.58 90 28976 76210 79639112
Adverse drug reaction 43.56 14.58 83 28983 66309 79649013
Confusional state 41.70 14.58 227 28839 317770 79397552
Parosmia 39.21 14.58 27 29039 6987 79708335
Maternal exposure during pregnancy 38.38 14.58 3 29063 136535 79578787
Therapeutic product effect incomplete 37.44 14.58 4 29062 141641 79573681
Product dose omission issue 37.26 14.58 22 29044 247515 79467807
Febrile neutropenia 36.98 14.58 19 29047 230980 79484342
Arthropathy 35.96 14.58 10 29056 177101 79538221
Alopecia 35.78 14.58 173 28893 231182 79484140
Contraindicated product administered 35.73 14.58 7 29059 157531 79557791
Product use issue 35.51 14.58 16 29050 209806 79505516
Nail bed bleeding 34.71 14.58 12 29054 674 79714648
Scrotal oedema 34.43 14.58 15 29051 1570 79713752
Infection 34.29 14.58 23 29043 241689 79473633
Therapeutic product effect decreased 33.74 14.58 9 29057 163854 79551468
Hyperkalaemia 33.74 14.58 105 28961 114293 79601029
Anxiety 33.64 14.58 179 28887 248333 79466989
Completed suicide 32.75 14.58 25 29041 245742 79469580
Gingival hypertrophy 32.74 14.58 18 29048 3124 79712198
Insomnia 32.11 14.58 175 28891 244995 79470327
Cardiac murmur 32.10 14.58 34 29032 15790 79699532
Syncope 31.29 14.58 139 28927 179310 79536012
Injection site pain 31.12 14.58 5 29061 129833 79585489
Peripheral swelling 31.07 14.58 186 28880 269431 79445891
Dyspnoea 30.78 14.58 460 28606 856565 78858757
Hepatic enzyme increased 30.78 14.58 14 29052 182596 79532726
Treatment failure 30.45 14.58 12 29054 170474 79544848
Abdominal pain upper 30.14 14.58 161 28905 223658 79491664
Sinusitis 28.54 14.58 18 29048 195483 79519839
Intentional product use issue 28.17 14.58 120 28946 151992 79563330
Discomfort 27.62 14.58 6 29060 125611 79589711
Spider naevus 26.66 14.58 7 29059 151 79715171
Medication error 26.05 14.58 69 28997 68573 79646749
Nasopharyngitis 25.57 14.58 33 29033 253848 79461474
Abdominal discomfort 25.17 14.58 167 28899 250560 79464762
Drug hypersensitivity 25.13 14.58 44 29022 298872 79416450
Liver function test abnormal 24.66 14.58 65 29001 64410 79650912
Frequent bowel movements 24.60 14.58 41 29025 29498 79685824
Bronchiectasis 24.14 14.58 35 29031 22351 79692971
Rhinitis 23.50 14.58 28 29038 14779 79700543
Colitis ulcerative 23.48 14.58 44 29022 34698 79680624
Back pain 23.32 14.58 190 28876 303990 79411332
Pruritus 22.40 14.58 231 28835 394417 79320905
Exposure during pregnancy 21.89 14.58 5 29061 101127 79614195
International normalised ratio increased 21.59 14.58 74 28992 84647 79630675
Septic shock 21.35 14.58 9 29057 122792 79592530
Impaired quality of life 20.88 14.58 26 29040 14360 79700962
Daydreaming 20.82 14.58 9 29057 924 79714398
Disease progression 20.67 14.58 22 29044 184340 79530982
Thrombocytopenia 20.57 14.58 41 29025 265218 79450104
Off label use 20.42 14.58 222 28844 906993 78808329
Swelling 19.99 14.58 30 29036 216681 79498641
Sleep inertia 19.90 14.58 4 29062 24 79715298
Orthostatic hypotension 19.85 14.58 55 29011 56109 79659213
Faeces discoloured 19.82 14.58 37 29029 29090 79686232
Impaired healing 19.65 14.58 4 29062 87651 79627671
Neutropenia 19.41 14.58 48 29018 287662 79427660
Malaise 19.12 14.58 267 28799 489602 79225720
Polyuria 18.46 14.58 25 29041 14989 79700333
Weight increased 18.15 14.58 47 29019 277339 79437983
Mucosal inflammation 17.91 14.58 3 29063 75577 79639745
Malignant neoplasm progression 17.89 14.58 14 29052 135976 79579346
Penile oedema 17.78 14.58 6 29060 313 79715009
Nodal rhythm 17.36 14.58 12 29054 3123 79712199
Toxicity to various agents 17.24 14.58 87 28979 421453 79293869
Interstitial lung disease 16.94 14.58 10 29056 112590 79602732
Drug interaction 16.89 14.58 228 28838 414955 79300367
Neuropathy peripheral 16.82 14.58 16 29050 141289 79574033
Wound 16.54 14.58 11 29055 116168 79599154
Blood cholesterol increased 16.48 14.58 5 29061 83715 79631607
Glomerulonephritis 16.38 14.58 12 29054 3421 79711901
Rheumatoid arthritis 16.35 14.58 32 29034 208438 79506884
Vasculitic rash 16.10 14.58 10 29056 2174 79713148
Helicobacter infection 16.01 14.58 3 29063 69701 79645621
Acute kidney injury 16.00 14.58 272 28794 519132 79196190
Hyperreflexia 15.23 14.58 17 29049 8368 79706954
Stomatitis 14.85 14.58 19 29047 146738 79568584
Injection site erythema 14.81 14.58 5 29061 78192 79637130
External ear pain 14.78 14.58 3 29063 19 79715303
Hospitalisation 14.70 14.58 8 29058 94228 79621094

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C07FB02 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS, OTHER COMBINATIONS
Beta blocking agents and calcium channel blockers
ATC C08CA02 CARDIOVASCULAR SYSTEM
CALCIUM CHANNEL BLOCKERS
SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS
Dihydropyridine derivatives
ATC C09BB05 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, COMBINATIONS
ACE inhibitors and calcium channel blockers
FDA CS M0006414 Dihydropyridines
FDA MoA N0000000069 Calcium Channel Antagonists
FDA EPC N0000175421 Dihydropyridine Calcium Channel Blocker
CHEBI has role CHEBI:35620 vasodilator agents
CHEBI has role CHEBI:35674 antihypertensive drugs
CHEBI has role CHEBI:38070 antiarrhythmic agent
CHEBI has role CHEBI:38215 calcium channel blockers
MeSH PA D000889 Anti-Arrhythmia Agents
MeSH PA D000959 Antihypertensive Agents
MeSH PA D002121 Calcium Channel Blockers
MeSH PA D000077264 Calcium-Regulating Hormones and Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D049990 Membrane Transport Modulators
MeSH PA D014665 Vasodilator Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Hypertensive disorder indication 38341003 DOID:10763
Prinzmetal angina off-label use 87343002
Angina pectoris off-label use 194828000
Raynaud's phenomenon off-label use 266261006
Hyperkalemia contraindication 14140009
Myocardial infarction contraindication 22298006 DOID:5844
Acute cerebrovascular insufficiency contraindication 29322000
Immunosuppression contraindication 38013005
Angioedema contraindication 41291007 DOID:1558
Low blood pressure contraindication 45007003
Chronic heart failure contraindication 48447003
Coronary arteriosclerosis contraindication 53741008 DOID:3393
Aortic valve stenosis contraindication 60573004 DOID:1712
Transplantation contraindication 77465005
Chronic idiopathic constipation contraindication 82934008
Hereditary angioneurotic edema contraindication 82966003 DOID:14735
Hyponatremia contraindication 89627008
Kidney disease contraindication 90708001 DOID:557
Disorder of connective tissue contraindication 105969002 DOID:65
Hypertrophic cardiomyopathy contraindication 233873004 DOID:11984
Disease of liver contraindication 235856003 DOID:409
Peripheral edema contraindication 271809000
Pregnancy, function contraindication 289908002
Renal artery stenosis contraindication 302233006
Neutropenic disorder contraindication 303011007 DOID:1227
Bone marrow depression contraindication 307762000
Hemodialysis with High-Flux Membrane contraindication




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 1.68 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Voltage-dependent L-type calcium channel subunit alpha-1D Ion channel BLOCKER WOMBAT-PK CHEMBL
Voltage-dependent L-type calcium channel subunit alpha-1C Ion channel BLOCKER WOMBAT-PK CHEMBL
Cytochrome P450 2C9 Enzyme IC50 5.34 DRUG MATRIX
Voltage-dependent T-type calcium channel subunit alpha-1H Ion channel Ki 5.17 WOMBAT-PK
Bile acid receptor Nuclear hormone receptor IC50 5.30 CHEMBL
Cystic fibrosis transmembrane conductance regulator Ion channel ACTIVATOR Ki 8.40 IUPHAR
Aldehyde oxidase Enzyme IC50 6.52 WOMBAT-PK
Sodium channel alpha subunits; brain (Types I, II, III) Ion channel IC50 4.43 CHEMBL
Adenosine receptor A3 GPCR Ki 6.22 DRUG MATRIX

External reference:

IDSource
4020159 VUID
N0000148116 NUI
D00319 KEGG_DRUG
4020159 VANDF
C0015772 UMLSCUI
CHEBI:585948 CHEBI
225 PDB_CHEM_ID
CHEMBL428768 ChEMBL_ID
CHEMBL1480 ChEMBL_ID
DB01023 DRUGBANK_ID
D015736 MESH_DESCRIPTOR_UI
3333 PUBCHEM_CID
4190 IUPHAR_LIGAND_ID
4877 INN_ID
OL961R6O2C UNII
203016 RXNORM
1621 MMSL
4716 MMSL
62563 MMSL
d00231 MMSL
003602 NDDF
108535009 SNOMEDCT_US
386863007 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Felodipine HUMAN PRESCRIPTION DRUG LABEL 1 0603-3581 TABLET, EXTENDED RELEASE 2.50 mg ORAL ANDA 22 sections
Felodipine HUMAN PRESCRIPTION DRUG LABEL 1 0603-3581 TABLET, EXTENDED RELEASE 2.50 mg ORAL ANDA 22 sections
Felodipine HUMAN PRESCRIPTION DRUG LABEL 1 0603-3582 TABLET, EXTENDED RELEASE 5 mg ORAL ANDA 22 sections
Felodipine HUMAN PRESCRIPTION DRUG LABEL 1 0603-3582 TABLET, EXTENDED RELEASE 5 mg ORAL ANDA 22 sections
Felodipine HUMAN PRESCRIPTION DRUG LABEL 1 0603-3583 TABLET, FILM COATED, EXTENDED RELEASE 10 mg ORAL ANDA 22 sections
Felodipine HUMAN PRESCRIPTION DRUG LABEL 1 0603-3583 TABLET, FILM COATED, EXTENDED RELEASE 10 mg ORAL ANDA 22 sections
Felodipine HUMAN PRESCRIPTION DRUG LABEL 1 13668-132 TABLET, EXTENDED RELEASE 2.50 mg ORAL ANDA 17 sections
Felodipine HUMAN PRESCRIPTION DRUG LABEL 1 13668-132 TABLET, EXTENDED RELEASE 2.50 mg ORAL ANDA 17 sections
Felodipine HUMAN PRESCRIPTION DRUG LABEL 1 13668-133 TABLET, EXTENDED RELEASE 5 mg ORAL ANDA 17 sections
Felodipine HUMAN PRESCRIPTION DRUG LABEL 1 13668-133 TABLET, EXTENDED RELEASE 5 mg ORAL ANDA 17 sections
Felodipine HUMAN PRESCRIPTION DRUG LABEL 1 13668-134 TABLET, EXTENDED RELEASE 10 mg ORAL ANDA 17 sections
Felodipine HUMAN PRESCRIPTION DRUG LABEL 1 13668-134 TABLET, EXTENDED RELEASE 10 mg ORAL ANDA 17 sections
FELODIPINE HUMAN PRESCRIPTION DRUG LABEL 1 23155-048 TABLET, EXTENDED RELEASE 2.50 mg ORAL ANDA 10 sections
FELODIPINE HUMAN PRESCRIPTION DRUG LABEL 1 23155-048 TABLET, EXTENDED RELEASE 2.50 mg ORAL ANDA 10 sections
FELODIPINE HUMAN PRESCRIPTION DRUG LABEL 1 23155-049 TABLET, EXTENDED RELEASE 5 mg ORAL ANDA 10 sections
FELODIPINE HUMAN PRESCRIPTION DRUG LABEL 1 23155-049 TABLET, EXTENDED RELEASE 5 mg ORAL ANDA 10 sections
FELODIPINE HUMAN PRESCRIPTION DRUG LABEL 1 23155-050 TABLET, EXTENDED RELEASE 10 mg ORAL ANDA 10 sections
FELODIPINE HUMAN PRESCRIPTION DRUG LABEL 1 23155-050 TABLET, EXTENDED RELEASE 10 mg ORAL ANDA 10 sections
Felodipine HUMAN PRESCRIPTION DRUG LABEL 1 50090-2421 TABLET, FILM COATED, EXTENDED RELEASE 10 mg ORAL ANDA 24 sections
Felodipine HUMAN PRESCRIPTION DRUG LABEL 1 50090-4808 TABLET, EXTENDED RELEASE 10 mg ORAL ANDA 19 sections
Felodipine Human Prescription Drug Label 1 50090-5870 TABLET, FILM COATED, EXTENDED RELEASE 10 mg ORAL ANDA 19 sections
Felodipine Human Prescription Drug Label 1 50090-5870 TABLET, FILM COATED, EXTENDED RELEASE 10 mg ORAL ANDA 19 sections
Felodipine HUMAN PRESCRIPTION DRUG LABEL 1 51407-087 TABLET, FILM COATED 2.50 mg ORAL ANDA 21 sections
Felodipine HUMAN PRESCRIPTION DRUG LABEL 1 51407-088 TABLET, FILM COATED 5 mg ORAL ANDA 21 sections
Felodipine HUMAN PRESCRIPTION DRUG LABEL 1 51407-089 TABLET, FILM COATED 10 mg ORAL ANDA 21 sections
Felodipine HUMAN PRESCRIPTION DRUG LABEL 1 53489-368 TABLET, FILM COATED, EXTENDED RELEASE 2.50 mg ORAL ANDA 24 sections
Felodipine HUMAN PRESCRIPTION DRUG LABEL 1 53489-369 TABLET, FILM COATED, EXTENDED RELEASE 5 mg ORAL ANDA 24 sections
Felodipine HUMAN PRESCRIPTION DRUG LABEL 1 53489-370 TABLET, FILM COATED, EXTENDED RELEASE 10 mg ORAL ANDA 24 sections
Felodipine HUMAN PRESCRIPTION DRUG LABEL 1 54868-0823 TABLET, FILM COATED 2.50 mg ORAL ANDA 24 sections
Felodipine HUMAN PRESCRIPTION DRUG LABEL 1 54868-0826 TABLET, FILM COATED, EXTENDED RELEASE 10 mg ORAL ANDA 24 sections