lacidipine Indications/Contra | FAERs | Orange Book | BioActivity |

Stem definitionDrug idCAS RN
calcium channel blockers, nifedipine derivatives 1532 103890-78-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • lacidipine
  • lacipil
  • lacirex
  • GR-43659X
  • motens
  • Molecular weight: 455.55
  • Formula: C26H33NO6
  • CLOGP: 5.93
  • LIPINSKI: 1
  • HAC: 7
  • HDO: 1
  • TPSA: 90.93
  • ALOGS: -5.31
  • ROTB: 11

Drug dosage:

DoseUnitRoute
4 mg O

Approvals:

None

FDA Adverse Event Reporting System

None

Pharmacologic Action:

SourceCodeDescription
ATC C08CA09 CARDIOVASCULAR SYSTEM
CALCIUM CHANNEL BLOCKERS
SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS
Dihydropyridine derivatives
MeSH PA D000959 Antihypertensive Agents
MeSH PA D002121 Calcium Channel Blockers
MeSH PA D000077264 Calcium-Regulating Hormones and Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D049990 Membrane Transport Modulators

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 2.23 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Voltage-gated L-type calcium channel Ion channel BLOCKER SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE
Sodium-dependent noradrenaline transporter Transporter Ki 5.25 DRUG MATRIX
D(3) dopamine receptor GPCR Ki 5.68 DRUG MATRIX
Adenosine receptor A3 GPCR Ki 5.64 DRUG MATRIX
Cytochrome P450 3A4 Enzyme IC50 6.05 DRUG MATRIX
Cytochrome P450 2C19 Enzyme IC50 5.70 DRUG MATRIX
Thromboxane-A synthase Enzyme IC50 5.77 DRUG MATRIX
Cytochrome P450 2C9 Enzyme IC50 5.70 DRUG MATRIX
Androgen receptor Transcription factor Ki 5.58 DRUG MATRIX

External reference:

IDSource
4025250 VUID
N0000179165 NUI
C0064568 UMLSCUI
D04657 KEGG_DRUG
260080034N UNII
6093 INN_ID
319299000 SNOMEDCT_US
4025250 VANDF
28382 RXNORM
395764001 SNOMEDCT_US
004453 NDDF
CHEMBL460291 ChEMBL_ID
DB09236 DRUGBANK_ID
CHEBI:135737 CHEBI
5311217 PUBCHEM_CID
C060285 MESH_SUPPLEMENTAL_RECORD_UI

Pharmaceutical products:

None