levamlodipine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| calcium channel blockers, nifedipine derivatives | 4099 | 103129-82-4 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
used to treat angina and hypertension
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
None
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Blood urea increased | 47.09 | 35.41 | 16 | 509 | 48774 | 79695089 |
| Neutrophil count increased | 46.32 | 35.41 | 14 | 511 | 29382 | 79714481 |
| Lymphocyte count decreased | 43.64 | 35.41 | 15 | 510 | 47274 | 79696589 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | C08CA17 | CARDIOVASCULAR SYSTEM CALCIUM CHANNEL BLOCKERS SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS Dihydropyridine derivatives |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 9.0 | Basic |
| pKa2 | 1.55 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Voltage-gated L-type calcium channel | Ion channel | BLOCKER | SCIENTIFIC LITERATURE | SCIENTIFIC LITERATURE |
External reference:
| ID | Source |
|---|---|
| 736178-83-9 | SECONDARY_CAS_RN |
| 150566-71-5 | SECONDARY_CAS_RN |
| D08941 | KEGG_DRUG |
| 4039729 | VANDF |
| C2717539 | UMLSCUI |
| 6UB | PDB_CHEM_ID |
| CHEMBL2111097 | ChEMBL_ID |
| CHEMBL2107350 | ChEMBL_ID |
| DB09237 | DRUGBANK_ID |
| C542574 | MESH_SUPPLEMENTAL_RECORD_UI |
| C000711385 | MESH_SUPPLEMENTAL_RECORD_UI |
| 8835 | INN_ID |
| 0P6NLP6806 | UNII |
| 9822750 | PUBCHEM_CID |
| 2376944 | RXNORM |
| 360548 | MMSL |
| d08466 | MMSL |
| 018248 | NDDF |
| 1217308000 | SNOMEDCT_US |
| 1217324004 | SNOMEDCT_US |
| 1217325003 | SNOMEDCT_US |
Pharmaceutical products:
None