manidipine Indications/Contra | FAERs | Orange Book | BioActivity |

Stem definitionDrug idCAS RN
calcium channel blockers, nifedipine derivatives 1631 89226-50-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • manidipine dihydrochloride
  • manidipine
  • (+/-)-Manidipine
  • franidipine
  • manidipine hydrochloride
  • manidipine HCl
  • Molecular weight: 610.71
  • Formula: C35H38N4O6
  • CLOGP: 7.02
  • LIPINSKI: 2
  • HAC: 10
  • HDO: 1
  • TPSA: 114.25
  • ALOGS: -5.79
  • ROTB: 12

Drug dosage:

DoseUnitRoute
10 mg O

Approvals:

None

FDA Adverse Event Reporting System

None

Pharmacologic Action:

SourceCodeDescription
ATC C08CA11 CARDIOVASCULAR SYSTEM
CALCIUM CHANNEL BLOCKERS
SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS
Dihydropyridine derivatives
ATC C09BB12 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, COMBINATIONS
ACE inhibitors and calcium channel blockers
MeSH PA D000959 Antihypertensive Agents
MeSH PA D002121 Calcium Channel Blockers
MeSH PA D000077264 Calcium-Regulating Hormones and Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D049990 Membrane Transport Modulators

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 6.7 Basic
pKa2 2.87 Basic
pKa3 2.2 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Voltage-gated L-type calcium channel Ion channel BLOCKER SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE
Cruzipain Enzyme IC50 5.22 CHEMBL

External reference:

IDSource
C0065656 UMLSCUI
D01553 KEGG_DRUG
6O4754US88 UNII
6300 INN_ID
765322004 SNOMEDCT_US
29275 RXNORM
008164 NDDF
CHEMBL1085699 ChEMBL_ID
DB09238 DRUGBANK_ID
CHEBI:135849 CHEBI
89226-75-5 SECONDARY_CAS_RN
4008 PUBCHEM_CID
C054218 MESH_SUPPLEMENTAL_RECORD_UI

Pharmaceutical products:

None