benidipine Indications/Contra | FAERs | Orange Book | BioActivity |

Stem definitionDrug idCAS RN
calcium channel blockers, nifedipine derivatives 3880 105979-17-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • benidipine
  • benidipine hydrochloride
  • coniel
  • benidipine HCl
  • Molecular weight: 505.57
  • Formula: C28H31N3O6
  • CLOGP: 5.71
  • LIPINSKI: 2
  • HAC: 9
  • HDO: 1
  • TPSA: 111.01
  • ALOGS: -5.32
  • ROTB: 9

Drug dosage:

None

Approvals:

DateAgencyCompanyOrphan
Jan. 1, 1991 YEAR INTRODUCED

FDA Adverse Event Reporting System

None

Pharmacologic Action:

SourceCodeDescription
ATC C08CA15 CARDIOVASCULAR SYSTEM
CALCIUM CHANNEL BLOCKERS
SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS
Dihydropyridine derivatives
MeSH PA D002121 Calcium Channel Blockers
MeSH PA D000077264 Calcium-Regulating Hormones and Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D049990 Membrane Transport Modulators
MeSH PA D014665 Vasodilator Agents

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 7.05 Basic
pKa2 2.23 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Voltage-gated L-type calcium channel Ion channel BLOCKER SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE
Voltage-dependent T-type calcium channel subunit alpha-1H Ion channel BLOCKER IC50 6.84 SCIENTIFIC LITERATURE

External reference:

IDSource
D02045 KEGG_DRUG
0A6746FWDL UNII
91599-74-5 SECONDARY_CAS_RN
6137 INN_ID
008170 NDDF
C061004 MESH_SUPPLEMENTAL_RECORD_UI
DB09231 DRUGBANK_ID
CHEBI:135806 CHEBI
10159 IUPHAR_LIGAND_ID
C050883 MESH_SUPPLEMENTAL_RECORD_UI
CHEMBL2074972 ChEMBL_ID
CHEMBL2105555 ChEMBL_ID
CHEMBL2218858 ChEMBL_ID
656668 PUBCHEM_CID

Pharmaceutical products:

None