amlodipine Indications/Contra | FAERs | Orange Book | BioActivity |

Stem definitionDrug idCAS RN
calcium channel blockers, nifedipine derivatives 183 88150-42-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • amlodipine
  • amlopres
  • racemic amlodipine
  • amlodipine besylate
  • amlodipine besilate
  • amlodipine maleate
  • amlodipine mesylate
  • amlodipine mesilate
A long-acting dihydropyridine calcium channel blocker. It is effective in the treatment of ANGINA PECTORIS and HYPERTENSION.
  • Molecular weight: 408.88
  • Formula: C20H25ClN2O5
  • CLOGP: 3.43
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 2
  • TPSA: 99.88
  • ALOGS: -4.74
  • ROTB: 10

Drug dosage:

DoseUnitRoute
5 mg O

Approvals:

DateAgencyCompanyOrphan
July 31, 1992 FDA PFIZER

FDA Adverse Event Reporting System

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 11149.19 23.52 3232 25089 39213 4571458
Hypotension 7074.45 23.52 2567 25754 64833 4545838
Toxicity to various agents 6344.70 23.52 2414 25907 69626 4541045
Intentional overdose 3489.07 23.52 1145 27176 20621 4590050
Drug hypersensitivity 3278.40 23.52 1492 26829 66908 4543763
Overdose 3130.60 23.52 1267 27054 42292 4568379
Shock 2474.98 23.52 716 27605 8200 4602471
Oedema peripheral 2352.14 23.52 1024 27297 40948 4569723
Dizziness 2165.01 23.52 1280 27041 98591 4512080
Acute kidney injury 2012.76 23.52 1083 27238 69348 4541323
Suicide attempt 1983.34 23.52 745 27576 20097 4590574
Bradycardia 1929.21 23.52 746 27575 21823 4588848
Blood pressure increased 1829.88 23.52 774 27547 28686 4581985
Drug interaction 1791.80 23.52 974 27347 63534 4547137
Fall 1742.25 23.52 1021 27300 77025 4533646
Metabolic acidosis 1669.59 23.52 574 27747 11866 4598805
Hypertension 1621.16 23.52 842 27479 49956 4560715
Blood pressure inadequately controlled 1517.79 23.52 344 27977 1281 4609390
Gingival hypertrophy 1480.75 23.52 301 28020 553 4610118
Syncope 1333.31 23.52 645 27676 32750 4577921
Headache 1136.46 23.52 934 27387 121439 4489232
Orthostatic hypotension 1114.68 23.52 366 27955 6508 4604163
Dyspnoea 1109.02 23.52 972 27349 138013 4472658
Pulmonary oedema 935.93 23.52 396 27925 14590 4596081
Malaise 928.52 23.52 732 27589 89425 4521246
Angioedema 923.66 23.52 426 27895 19339 4591332
Cardiac arrest 881.67 23.52 492 27829 33515 4577156
Cardiogenic shock 869.26 23.52 286 28035 5112 4605559
Joint swelling 861.28 23.52 432 27889 23646 4587025
Loss of consciousness 840.84 23.52 485 27836 35197 4575474
Hypertensive crisis 833.46 23.52 264 28057 4155 4606516
Hyponatraemia 778.07 23.52 407 27914 24323 4586348
Hyperkalaemia 773.15 23.52 352 27969 15485 4595186
Blood pressure decreased 753.32 23.52 359 27962 17541 4593130
Drug ineffective 724.53 23.52 886 27435 185175 4425496
Hypokalaemia 680.61 23.52 340 27981 18420 4592251
Vomiting 680.06 23.52 695 27626 119004 4491667
Lactic acidosis 648.03 23.52 286 28035 11670 4599001
Nausea 642.64 23.52 815 27506 176518 4434153
Cough 626.78 23.52 477 27844 55110 4555561
Peripheral swelling 623.49 23.52 361 27960 26331 4584340
Palpitations 617.71 23.52 350 27971 24496 4586175
Asthenia 600.50 23.52 560 27761 85603 4525068
Renal failure 596.09 23.52 412 27909 40957 4569714
Oedema 587.76 23.52 308 28013 18443 4592228
Cardiac failure 569.01 23.52 343 27978 26945 4583726
Depressed level of consciousness 562.39 23.52 279 28042 14875 4595796
Renal impairment 547.76 23.52 326 27995 25012 4585659
Blood creatinine increased 539.96 23.52 330 27991 26570 4584101
Somnolence 537.23 23.52 395 27926 43265 4567406
Fatigue 515.31 23.52 662 27659 144904 4465767
Chest pain 503.93 23.52 404 27917 50296 4560375
Circulatory collapse 493.17 23.52 208 28113 7577 4603094
Pruritus 477.13 23.52 457 27864 72115 4538556
Rhabdomyolysis 465.75 23.52 268 28053 19290 4591381
Myalgia 462.92 23.52 356 27965 41692 4568979
Confusional state 461.71 23.52 378 27943 48456 4562215
Anuria 460.09 23.52 165 28156 3850 4606821
Hyperglycaemia 442.48 23.52 216 28105 11106 4599565
Swollen tongue 440.98 23.52 199 28122 8551 4602120
Tachycardia 440.84 23.52 307 28014 30838 4579833
Swelling 415.13 23.52 270 28051 24212 4586459
Cardio-respiratory arrest 404.83 23.52 246 28075 19576 4591095
Condition aggravated 402.45 23.52 377 27944 57794 4552877
Rash 395.55 23.52 501 27820 107887 4502784
Heart rate decreased 394.78 23.52 172 28149 6788 4603883
Hypoglycaemia 372.15 23.52 227 28094 18182 4592489
Pain in extremity 371.41 23.52 376 27945 63363 4547308
Blood pressure systolic increased 365.39 23.52 142 28179 4166 4606505
Blood creatine phosphokinase increased 359.64 23.52 207 28114 14892 4595779
Respiratory failure 358.39 23.52 268 28053 30058 4580613
Sinus bradycardia 357.03 23.52 140 28181 4209 4606462
Feeling abnormal 344.26 23.52 282 28039 36123 4574548
Gingival bleeding 341.66 23.52 129 28192 3492 4607179
Oliguria 340.83 23.52 120 28201 2647 4608024
Atrial fibrillation 336.15 23.52 261 28060 30954 4579717
Death 334.11 23.52 641 27680 197522 4413149
Gait disturbance 332.23 23.52 277 28044 36363 4574308
Poisoning 330.24 23.52 145 28176 5829 4604842
Cerebrovascular accident 327.02 23.52 291 28030 41709 4568962
Atrioventricular block complete 326.83 23.52 120 28201 2998 4607673
Haemodynamic instability 326.77 23.52 116 28205 2623 4608048
Diabetes mellitus 325.79 23.52 196 28125 15305 4595366
Non-cardiogenic pulmonary oedema 324.68 23.52 71 28250 213 4610458
Toxic epidermal necrolysis 322.05 23.52 144 28177 6048 4604623
Muscular weakness 316.72 23.52 236 28085 26314 4584357
Paraesthesia 308.99 23.52 261 28060 34872 4575799
Blood lactic acid increased 308.82 23.52 102 28219 1840 4608831
Heart rate increased 300.82 23.52 199 28122 18343 4592328
Medication error 299.63 23.52 181 28140 14235 4596436
Anxiety 299.37 23.52 294 28027 47717 4562954
Hypoxia 296.84 23.52 174 28147 12947 4597724
Muscle spasms 296.49 23.52 256 28065 35234 4575437
Left ventricular hypertrophy 296.08 23.52 95 28226 1557 4609114
Coma 293.88 23.52 192 28129 17327 4593344
Respiratory arrest 293.20 23.52 174 28147 13246 4597425
Arthralgia 287.66 23.52 372 27949 81622 4529049
Abdominal pain 287.22 23.52 319 28002 59705 4550966
Swelling face 287.15 23.52 178 28143 14662 4596009
Lethargy 282.01 23.52 186 28135 17055 4593616
Arrhythmia 280.33 23.52 170 28151 13462 4597209
Pain 279.52 23.52 391 27930 92479 4518192
Blood glucose increased 277.21 23.52 210 28111 23994 4586677
Electrocardiogram QT prolonged 277.21 23.52 176 28145 15119 4595552
Generalised oedema 272.08 23.52 116 28205 4335 4606336
Vasoplegia syndrome 270.51 23.52 65 28256 328 4610343
Weight decreased 270.14 23.52 295 28026 54169 4556502
Depression 269.47 23.52 277 28044 47456 4563215
Erythema 265.46 23.52 259 28062 41681 4568990
Drug intolerance 265.36 23.52 196 28125 21550 4589121
Asthma 263.88 23.52 179 28142 17195 4593476
Decreased appetite 263.39 23.52 296 28025 56101 4554570
Exposure via ingestion 252.00 23.52 82 28239 1408 4609263
Chest discomfort 251.79 23.52 195 28126 23015 4587656
Gingival swelling 249.90 23.52 78 28243 1163 4609508
Sinus tachycardia 246.66 23.52 120 28201 6114 4604557
Angina pectoris 245.97 23.52 138 28183 9443 4601228
Balance disorder 245.72 23.52 167 28154 16089 4594582
Vertigo 243.73 23.52 161 28160 14795 4595876
Weight increased 242.95 23.52 232 28089 36349 4574322
Presyncope 239.87 23.52 122 28199 6842 4603829
Acute respiratory distress syndrome 239.69 23.52 125 28196 7388 4603283
Product substitution issue 235.92 23.52 133 28188 9185 4601486
Diarrhoea 234.52 23.52 471 27850 149714 4460957
Anaemia 231.28 23.52 312 28009 71248 4539423
Agranulocytosis 231.08 23.52 122 28199 7395 4603276
Intentional product misuse 226.31 23.52 167 28154 18326 4592345
Dysarthria 226.17 23.52 143 28178 12189 4598482
Insomnia 223.70 23.52 245 28076 45100 4565571
Tachypnoea 223.20 23.52 104 28217 4807 4605864
Electrocardiogram QRS complex prolonged 223.18 23.52 81 28240 1955 4608716
General physical health deterioration 223.05 23.52 199 28122 28579 4582092
Atrioventricular block 219.59 23.52 88 28233 2802 4607869
Visual impairment 218.72 23.52 167 28154 19293 4591378
Pleural effusion 217.99 23.52 183 28138 24215 4586456
Cardiotoxicity 217.27 23.52 88 28233 2882 4607789
Myocardial depression 216.91 23.52 44 28277 79 4610592
Dehydration 216.47 23.52 233 28088 42057 4568614
Abdominal pain upper 209.42 23.52 210 28111 34905 4575766
Atrioventricular block first degree 208.02 23.52 77 28244 1968 4608703
Vision blurred 205.18 23.52 178 28143 24625 4586046
Distributive shock 204.81 23.52 48 28273 213 4610458
Urticaria 202.47 23.52 218 28103 39355 4571316
Pneumonia 202.03 23.52 356 27965 102459 4508212
Eczema 201.80 23.52 103 28218 5818 4604853
Mental status changes 201.08 23.52 133 28188 12243 4598428
Poisoning deliberate 200.46 23.52 77 28244 2185 4608486
Constipation 199.68 23.52 223 28098 41931 4568740
Erectile dysfunction 198.33 23.52 95 28226 4674 4605997
Blister 197.52 23.52 128 28193 11381 4599290
Pemphigoid 194.51 23.52 76 28245 2260 4608411
Acidosis 192.52 23.52 84 28237 3322 4607349
Tremor 189.45 23.52 202 28119 36057 4574614
Chronic kidney disease 189.12 23.52 121 28200 10524 4600147
Stevens-Johnson syndrome 186.00 23.52 111 28210 8528 4602143
Alanine aminotransferase increased 180.87 23.52 176 28145 28197 4582474
Disorientation 178.81 23.52 124 28197 12335 4598336
Lip swelling 178.47 23.52 106 28215 8073 4602598
Linear IgA disease 178.20 23.52 54 28267 725 4609946
Blood urea increased 176.96 23.52 108 28213 8642 4602029
Multiple organ dysfunction syndrome 176.49 23.52 145 28176 18611 4592060
Blood pressure fluctuation 172.50 23.52 81 28240 3809 4606862
Cardiomegaly 170.83 23.52 87 28234 4890 4605781
Altered state of consciousness 170.52 23.52 102 28219 7869 4602802
Unresponsive to stimuli 170.12 23.52 111 28210 9982 4600689
Leukocytosis 169.35 23.52 100 28221 7534 4603137
Flushing 168.40 23.52 143 28178 19209 4591462
Therapy non-responder 168.37 23.52 132 28189 15845 4594826
Dyspnoea exertional 168.34 23.52 111 28210 10161 4600510
Tinnitus 167.68 23.52 106 28215 9027 4601644
Pyrexia 166.90 23.52 336 27985 106808 4503863
Dry mouth 166.34 23.52 121 28200 12980 4597691
Dysphagia 165.78 23.52 160 28161 25371 4585300
Hyperlipidaemia 165.23 23.52 86 28235 5059 4605612
Aspartate aminotransferase increased 165.17 23.52 158 28163 24780 4585891
Gamma-glutamyltransferase increased 163.84 23.52 113 28208 11141 4599530
Toxic skin eruption 163.36 23.52 81 28240 4299 4606372
Haemoglobin decreased 162.72 23.52 190 28131 37467 4573204
Urinary incontinence 161.94 23.52 96 28225 7284 4603387
Nocturia 161.58 23.52 65 28256 2090 4608581
Foetal exposure during pregnancy 161.48 23.52 151 28170 23018 4587653
Urine output decreased 160.03 23.52 72 28249 3065 4607606
Proteinuria 157.96 23.52 91 28230 6545 4604126
Cholestasis 155.68 23.52 96 28225 7824 4602847
Back pain 154.83 23.52 215 28106 50384 4560287
Gingivitis 154.25 23.52 63 28258 2108 4608563
Drug abuse 153.61 23.52 160 28161 27787 4582884
Dermatitis exfoliative 152.93 23.52 69 28252 2957 4607714
Hyperhidrosis 151.54 23.52 164 28157 29753 4580918
Body temperature decreased 151.29 23.52 65 28256 2474 4608197
Diabetes mellitus inadequate control 149.10 23.52 74 28247 3935 4606736
Hepatitis 148.79 23.52 110 28211 12095 4598576
Hepatic function abnormal 147.23 23.52 117 28204 14319 4596352
Product prescribing error 146.09 23.52 89 28232 7097 4603574
Drug reaction with eosinophilia and systemic symptoms 143.76 23.52 106 28215 11607 4599064
Blood pressure abnormal 142.28 23.52 65 28256 2868 4607803
Glycosylated haemoglobin increased 142.19 23.52 72 28249 3997 4606674
Hypersensitivity 141.80 23.52 179 28142 38242 4572429
Treatment noncompliance 141.25 23.52 106 28215 11921 4598750
Myocardial infarction 140.99 23.52 203 28118 49173 4561498
Blood potassium decreased 140.33 23.52 90 28231 7856 4602815
Cerebral infarction 139.68 23.52 101 28220 10731 4599940
Pollakiuria 138.67 23.52 86 28235 7079 4603592
Liver disorder 137.53 23.52 108 28213 12990 4597681
Eosinophilia 135.50 23.52 84 28237 6909 4603762
Drug eruption 134.79 23.52 82 28239 6521 4604150
Abdominal distension 134.58 23.52 122 28199 17867 4592804
Parkinsonism 133.20 23.52 64 28257 3169 4607502
Drug-induced liver injury 131.53 23.52 89 28232 8502 4602169
Pharyngeal oedema 129.92 23.52 75 28246 5414 4605257
Depressed mood 129.19 23.52 89 28232 8755 4601916
Interstitial lung disease 127.32 23.52 122 28199 19163 4591508
Coma scale abnormal 126.73 23.52 50 28271 1526 4609145
Product dispensing error 125.88 23.52 76 28245 5961 4604710
Conjoined twins 125.83 23.52 24 28297 25 4610646
Hypoperfusion 125.81 23.52 37 28284 445 4610226
Vasculitis 124.41 23.52 67 28254 4224 4606447
Thrombocytopenia 121.72 23.52 186 28135 47487 4563184
Respiratory disorder 121.43 23.52 82 28239 7806 4602865
Hemiplegia 121.21 23.52 58 28263 2845 4607826
Face oedema 121.18 23.52 77 28244 6613 4604058
Nodal rhythm 121.04 23.52 40 28281 722 4609949
Mitral valve incompetence 121.03 23.52 68 28253 4660 4606011
Arteriosclerosis 120.01 23.52 61 28260 3413 4607258
Fluid retention 119.53 23.52 94 28227 11327 4599344
Cardiac failure congestive 119.27 23.52 152 28169 32770 4577901
Fluid overload 119.04 23.52 69 28252 5019 4605652
Blood cholesterol increased 118.73 23.52 84 28237 8622 4602049
Seizure 118.52 23.52 189 28132 50048 4560623
Drug level increased 117.99 23.52 74 28247 6212 4604459
Premature baby 116.73 23.52 88 28233 9963 4600708
Burning sensation 116.32 23.52 94 28227 11778 4598893
Renin increased 115.61 23.52 26 28295 92 4610579
Disturbance in attention 114.88 23.52 89 28232 10492 4600179
Pseudolymphoma 114.32 23.52 31 28290 271 4610400
Accidental overdose 114.12 23.52 84 28237 9171 4601500
Blood sodium decreased 114.08 23.52 70 28251 5652 4605019
Urinary retention 113.88 23.52 86 28235 9761 4600910
Intestinal ischaemia 113.47 23.52 52 28269 2311 4608360
Renal artery stenosis 111.61 23.52 35 28286 530 4610141
Sleep disorder 109.97 23.52 89 28232 11174 4599497
Personality disorder 109.71 23.52 36 28285 635 4610036
Discomfort 108.82 23.52 78 28243 8172 4602499
Suicidal ideation 108.71 23.52 118 28203 21465 4589206
Blood pressure diastolic decreased 107.56 23.52 47 28274 1864 4608807
Hypoaesthesia 106.59 23.52 141 28180 31524 4579147
Jaundice 106.09 23.52 91 28230 12383 4598288
Chronic obstructive pulmonary disease 106.02 23.52 95 28226 13699 4596972
Respiratory rate increased 105.88 23.52 53 28268 2870 4607801
Ascites 105.63 23.52 90 28231 12135 4598536
Loose tooth 105.27 23.52 38 28283 902 4609769
Pallor 105.26 23.52 74 28247 7518 4603153
Product complaint 104.37 23.52 74 28247 7620 4603051
Peripheral coldness 104.24 23.52 53 28268 2967 4607704
Productive cough 103.99 23.52 80 28241 9333 4601338
Pancreatitis acute 103.32 23.52 77 28244 8566 4602105
Abdominal discomfort 102.64 23.52 131 28190 28277 4582394
Aortic stenosis 101.91 23.52 41 28280 1318 4609353
Petechiae 101.88 23.52 57 28264 3874 4606797
Memory impairment 101.80 23.52 111 28210 20292 4590379
Acute generalised exanthematous pustulosis 101.17 23.52 52 28269 2978 4607693
Vasodilatation 101.16 23.52 34 28287 648 4610023
Left ventricular dysfunction 100.10 23.52 50 28271 2695 4607976
C-reactive protein increased 99.98 23.52 89 28232 12723 4597948
Gout 98.85 23.52 58 28263 4315 4606356
Hepatocellular injury 98.07 23.52 72 28249 7828 4602843
Haemodialysis 97.98 23.52 60 28261 4827 4605844
Atrioventricular block second degree 96.80 23.52 40 28281 1379 4609292
Epistaxis 96.50 23.52 106 28215 19537 4591134
Dysuria 96.38 23.52 72 28249 8038 4602633
Hypertensive emergency 96.30 23.52 30 28291 444 4610227
Blood potassium increased 95.67 23.52 60 28261 5035 4605636
Speech disorder 95.59 23.52 83 28238 11479 4599192
Chronic pigmented purpura 95.04 23.52 21 28300 67 4610604
Product administration error 95.02 23.52 72 28249 8212 4602459
Low birth weight baby 94.82 23.52 48 28273 2662 4608009
Continuous haemodiafiltration 94.81 23.52 32 28289 618 4610053
Tricuspid valve incompetence 94.14 23.52 50 28271 3064 4607607
Hepatic steatosis 94.09 23.52 64 28257 6164 4604507
Rash erythematous 92.09 23.52 78 28243 10431 4600240
Hemiparesis 91.76 23.52 64 28257 6420 4604251
Bundle branch block right 91.67 23.52 44 28277 2173 4608498
Stress 91.64 23.52 76 28245 9872 4600799
Cholelithiasis 91.16 23.52 74 28247 9328 4601343
Coronary artery disease 90.97 23.52 94 28227 16158 4594513
Allergic reaction to excipient 90.57 23.52 21 28300 88 4610583
Respiratory distress 90.29 23.52 79 28242 11037 4599634
Purpura 90.23 23.52 52 28269 3740 4606931
Wheezing 89.94 23.52 79 28242 11095 4599576
Platelet count decreased 89.92 23.52 137 28184 34865 4575806
Hyperdynamic left ventricle 89.10 23.52 20 28301 70 4610601
Cerebral haemorrhage 88.64 23.52 85 28236 13356 4597315
Wrong product administered 88.18 23.52 49 28272 3286 4607385
Photosensitivity reaction 88.18 23.52 55 28266 4571 4606100
Ejection fraction decreased 88.11 23.52 59 28262 5537 4605134
Respiratory depression 88.05 23.52 57 28264 5053 4605618
Eyelid oedema 87.89 23.52 53 28268 4146 4606525
Heart rate irregular 86.77 23.52 54 28267 4470 4606201
Coordination abnormal 86.31 23.52 50 28271 3632 4607039
Myopathy 85.60 23.52 50 28271 3688 4606983
Glomerular filtration rate decreased 85.58 23.52 48 28273 3278 4607393
Pericardial effusion 85.48 23.52 67 28254 8031 4602640
Myocardial ischaemia 85.26 23.52 59 28262 5843 4604828
Dyspepsia 84.75 23.52 90 28231 15964 4594707
Intentional self-injury 84.30 23.52 64 28257 7319 4603352
Glaucoma 82.74 23.52 48 28273 3496 4607175
Incorrect dose administered 82.31 23.52 97 28224 19288 4591383
Transient ischaemic attack 81.42 23.52 76 28245 11546 4599125
Diastolic dysfunction 81.26 23.52 34 28287 1210 4609461
Lower respiratory tract infection 81.06 23.52 71 28250 9932 4600739
Tubulointerstitial nephritis 81.03 23.52 58 28263 6061 4604610
Mental disorder 80.97 23.52 63 28258 7471 4603200
Eating disorder 80.58 23.52 48 28273 3672 4606999
Nasopharyngitis 80.24 23.52 127 28194 33390 4577281
Hypovolaemic shock 80.17 23.52 38 28283 1824 4608847
Blood pressure systolic decreased 80.09 23.52 36 28285 1528 4609143
Persistent cloaca 79.98 23.52 15 28306 13 4610658
Electrocardiogram abnormal 79.36 23.52 43 28278 2743 4607928
Musculoskeletal stiffness 79.29 23.52 94 28227 18808 4591863
Cataract 79.24 23.52 69 28252 9577 4601094
Pulmonary hypoplasia 77.87 23.52 23 28298 281 4610390
Rales 77.47 23.52 39 28282 2137 4608534
Fryns syndrome 77.42 23.52 13 28308 0 4610671
Foetal growth restriction 77.00 23.52 41 28280 2525 4608146
Rash pruritic 76.81 23.52 76 28245 12407 4598264
Gravitational oedema 76.50 23.52 23 28298 300 4610371
Subacute cutaneous lupus erythematosus 75.92 23.52 27 28294 613 4610058
Extrasystoles 75.82 23.52 37 28284 1895 4608776
Macrophages increased 75.81 23.52 15 28306 22 4610649
Oropharyngeal pain 75.76 23.52 88 28233 17231 4593440
Head injury 75.37 23.52 60 28261 7355 4603316
Vitamin D deficiency 75.07 23.52 38 28283 2107 4608564
Nervousness 74.85 23.52 61 28260 7731 4602940
Brain natriuretic peptide increased 74.61 23.52 32 28289 1212 4609459
Type 2 diabetes mellitus 74.51 23.52 48 28273 4219 4606452
Sleep apnoea syndrome 74.50 23.52 49 28272 4462 4606209
Muscle spasticity 74.24 23.52 44 28277 3334 4607337
Agitation 74.19 23.52 103 28218 24097 4586574
Angiopathy 73.63 23.52 35 28286 1691 4608980
Hepatotoxicity 73.54 23.52 62 28259 8237 4602434
Bundle branch block left 73.34 23.52 36 28285 1868 4608803
Guillain-Barre syndrome 73.19 23.52 35 28286 1714 4608957
Urinary tract infection 73.17 23.52 139 28182 42251 4568420
Cellulitis 73.16 23.52 85 28236 16647 4594024
Acute pulmonary oedema 72.72 23.52 40 28281 2629 4608042
Inflammation 72.19 23.52 67 28254 10104 4600567
Skin ulcer 72.07 23.52 58 28263 7220 4603451
Rash maculo-papular 72.06 23.52 62 28259 8467 4602204
Respiratory alkalosis 72.03 23.52 26 28295 617 4610054
Blood lactate dehydrogenase increased 71.94 23.52 59 28262 7544 4603127
Red blood cell sedimentation rate increased 71.94 23.52 43 28278 3310 4607361
Electrolyte imbalance 71.66 23.52 45 28276 3784 4606887
Arthritis 71.63 23.52 79 28242 14621 4596050
Cardiac disorder 71.63 23.52 85 28236 17024 4593647
Intestinal malrotation 71.20 23.52 17 28304 83 4610588
Lichen planus 71.15 23.52 27 28294 740 4609931
Wound 71.11 23.52 48 28273 4564 4606107
Pneumonia aspiration 70.95 23.52 65 28256 9641 4601030
Renal disorder 70.79 23.52 64 28257 9332 4601339
Left ventricular enlargement 70.63 23.52 16 28305 59 4610612
Pulmonary congestion 70.21 23.52 45 28276 3921 4606750
Hypertensive heart disease 69.98 23.52 28 28293 887 4609784
Contusion 69.84 23.52 89 28232 19169 4591502
Polyuria 69.83 23.52 39 28282 2641 4608030
Renal tubular necrosis 69.67 23.52 45 28276 3973 4606698
Dermatitis 69.58 23.52 47 28274 4474 4606197
Neurologic neglect syndrome 69.28 23.52 18 28303 131 4610540
Pulseless electrical activity 68.93 23.52 36 28285 2131 4608540
Lichen nitidus 68.79 23.52 12 28309 3 4610668
Bronchitis 68.59 23.52 90 28231 19950 4590721
Maternal exposure during pregnancy 68.41 23.52 83 28238 17010 4593661
Paralysis 68.14 23.52 42 28279 3417 4607254
Cardiac murmur 67.68 23.52 40 28281 3015 4607656
Hepatitis cholestatic 67.67 23.52 38 28283 2600 4608071
Urachal abnormality 67.46 23.52 13 28308 15 4610656
Irritable bowel syndrome 67.43 23.52 38 28283 2618 4608053
Photophobia 67.33 23.52 43 28278 3723 4606948
Cold sweat 67.09 23.52 44 28277 3987 4606684
Feeling hot 66.80 23.52 65 28256 10396 4600275
Bladder irritation 66.70 23.52 16 28305 80 4610591
Electrocardiogram ST segment depression 66.60 23.52 29 28292 1140 4609531
Periodontitis 66.59 23.52 28 28293 1009 4609662
Conduction disorder 66.46 23.52 26 28295 775 4609896
Gynaecomastia 66.11 23.52 36 28285 2319 4608352
Acute respiratory failure 65.67 23.52 52 28269 6324 4604347
Hyperleukocytosis 65.41 23.52 19 28302 218 4610453
Visual acuity reduced 65.32 23.52 63 28258 9967 4600704
Steatorrhoea 65.10 23.52 19 28302 222 4610449
Feeling cold 65.04 23.52 47 28274 4984 4605687
Hypovolaemia 64.78 23.52 37 28284 2616 4608055
Exposure during pregnancy 64.32 23.52 114 28207 32857 4577814
Tongue oedema 64.07 23.52 31 28290 1558 4609113
Blood alkaline phosphatase increased 64.04 23.52 69 28252 12438 4598233
Throat irritation 63.98 23.52 54 28267 7184 4603487
Pulmonary hypertension 63.87 23.52 58 28263 8505 4602166
Haematochezia 63.73 23.52 65 28256 10999 4599672
Orthostatic intolerance 63.64 23.52 20 28301 305 4610366
Brain injury 63.63 23.52 34 28287 2109 4608562
Diabetic neuropathy 63.54 23.52 27 28294 999 4609672
Neck pain 63.17 23.52 66 28255 11486 4599185
Panic attack 62.89 23.52 50 28271 6117 4604554
Oesophageal atresia 62.75 23.52 20 28301 320 4610351
Nephrotic syndrome 62.64 23.52 37 28284 2786 4607885
Ventricular fibrillation 62.56 23.52 47 28274 5290 4605381
Congenital bladder anomaly 62.20 23.52 15 28306 77 4610594
Oligohydramnios 61.95 23.52 28 28293 1204 4609467
Hypersensitivity vasculitis 61.82 23.52 36 28285 2640 4608031
Muscle tightness 61.79 23.52 38 28283 3079 4607592
Acute motor-sensory axonal neuropathy 61.72 23.52 15 28306 80 4610591
Blood urine present 61.60 23.52 42 28279 4059 4606612
Carotid artery thrombosis 60.94 23.52 18 28303 220 4610451
White blood cell count increased 60.88 23.52 74 28247 15193 4595478
Wrong patient received product 60.56 23.52 22 28299 532 4610139
Pancreatitis 60.11 23.52 78 28243 17100 4593571
Melaena 60.10 23.52 60 28261 9898 4600773
Hypothermia 59.50 23.52 42 28279 4292 4606379
Eye disorder 59.40 23.52 45 28276 5129 4605542
Concomitant disease progression 59.33 23.52 26 28295 1038 4609633
Hypomagnesaemia 59.13 23.52 45 28276 5164 4605507
Hypokinesia 59.10 23.52 37 28284 3094 4607577
Bradypnoea 58.94 23.52 24 28297 796 4609875
Restlessness 58.90 23.52 58 28263 9411 4601260
Blood ethanol increased 58.62 23.52 15 28306 102 4610569
Haemolytic anaemia 58.55 23.52 41 28280 4137 4606534
Prescription drug used without a prescription 58.47 23.52 21 28300 491 4610180
Hypertensive angiopathy 58.41 23.52 11 28310 10 4610661
Alveolitis 57.97 23.52 24 28297 831 4609840
Gait inability 57.80 23.52 58 28263 9627 4601044
Impaired work ability 57.79 23.52 36 28285 2984 4607687
Hypoacusis 57.69 23.52 48 28273 6261 4604410
Cognitive disorder 57.53 23.52 60 28261 10421 4600250
Skin exfoliation 57.40 23.52 61 28260 10826 4599845
Chromaturia 57.23 23.52 46 28275 5715 4604956
Eye pain 57.03 23.52 52 28269 7665 4603006
Blood uric acid increased 56.91 23.52 30 28291 1810 4608861
Blood bilirubin increased 56.53 23.52 65 28256 12587 4598084
Flatulence 56.43 23.52 53 28268 8111 4602560
International normalised ratio increased 56.14 23.52 75 28246 16913 4593758
Skin lesion 56.14 23.52 51 28270 7482 4603189
Ischaemic stroke 56.01 23.52 51 28270 7503 4603168
Therapeutic response unexpected 55.82 23.52 49 28272 6873 4603798
Supraventricular tachycardia 55.78 23.52 39 28282 3926 4606745
Thrombocytosis 55.71 23.52 29 28292 1705 4608966
Crepitations 55.64 23.52 26 28295 1208 4609463
Albumin urine present 55.63 23.52 15 28306 128 4610543
Adjustment disorder 55.57 23.52 18 28303 304 4610367
Rash macular 55.32 23.52 45 28276 5687 4604984
Hyperuricaemia 55.25 23.52 29 28292 1734 4608937
Head discomfort 55.01 23.52 32 28289 2342 4608329
Gastrointestinal haemorrhage 55.01 23.52 102 28219 30433 4580238
Congenital nail disorder 54.70 23.52 13 28308 62 4610609
Transaminases increased 54.54 23.52 56 28265 9550 4601121
Aphasia 54.50 23.52 54 28267 8826 4601845
Differentiation syndrome 54.37 23.52 19 28302 409 4610262
Acute myocardial infarction 54.29 23.52 68 28253 14391 4596280
Sopor 54.24 23.52 47 28274 6479 4604192
Blood bicarbonate decreased 54.08 23.52 24 28297 988 4609683
Noninfective gingivitis 53.99 23.52 17 28304 261 4610410
Dysmorphism 53.99 23.52 24 28297 992 4609679
Haematocrit decreased 53.98 23.52 54 28267 8928 4601743
Dermatomyositis 53.77 23.52 22 28299 739 4609932
Sudden death 53.71 23.52 43 28278 5312 4605359
Periorbital oedema 53.03 23.52 29 28292 1884 4608787
Hyperthyroidism 52.90 23.52 38 28283 3992 4606679
Hepatic failure 52.86 23.52 64 28257 13085 4597586
Nightmare 52.83 23.52 48 28273 7042 4603629
Diplopia 52.69 23.52 46 28275 6405 4604266
Diabetic nephropathy 52.50 23.52 20 28301 554 4610117
Labile hypertension 52.40 23.52 14 28307 115 4610556
Dry skin 52.00 23.52 58 28263 10864 4599807
Tracheo-oesophageal fistula 51.90 23.52 17 28304 298 4610373
Suspected suicide attempt 51.90 23.52 11 28310 27 4610644
Cholecystitis 51.73 23.52 38 28283 4133 4606538
Gingival pain 51.57 23.52 27 28294 1606 4609065
Chills 51.53 23.52 96 28225 28743 4581928
Glucose urine present 51.53 23.52 18 28303 387 4610284
Aortic aneurysm 51.39 23.52 27 28294 1618 4609053
C-reactive protein decreased 51.11 23.52 15 28306 179 4610492
Pulse absent 51.03 23.52 29 28292 2030 4608641
Hepatic neoplasm 50.95 23.52 22 28299 847 4609824
Pulse abnormal 50.88 23.52 20 28301 604 4610067
Amnesia 50.49 23.52 62 28259 12859 4597812
Electrocardiogram T wave inversion 50.42 23.52 24 28297 1163 4609508
Neutrophilia 50.36 23.52 24 28297 1166 4609505
Blood glucose decreased 50.29 23.52 43 28278 5822 4604849
Blindness 50.08 23.52 47 28274 7185 4603486
Ventricular extrasystoles 49.84 23.52 37 28284 4089 4606582
Affect lability 49.67 23.52 35 28286 3567 4607104
Hyperaldosteronism 49.63 23.52 13 28308 98 4610573
Delirium 49.53 23.52 61 28260 12691 4597980
Muscle atrophy 49.39 23.52 30 28291 2377 4608294
Septic shock 49.35 23.52 70 28251 16696 4593975
Crystalluria 49.32 23.52 14 28307 147 4610524
Oxygen saturation decreased 49.22 23.52 64 28257 14057 4596614
Haemorrhage subcutaneous 48.93 23.52 24 28297 1243 4609428
Congenital diaphragmatic hernia 48.82 23.52 14 28307 153 4610518
Hepatomegaly 48.70 23.52 35 28286 3680 4606991
Troponin I increased 48.65 23.52 20 28301 680 4609991
Blood chloride increased 48.63 23.52 20 28301 681 4609990
Motor dysfunction 48.56 23.52 30 28291 2450 4608221
Musculoskeletal pain 48.45 23.52 69 28252 16519 4594152
Cardiac failure acute 48.35 23.52 30 28291 2469 4608202
Supraventricular extrasystoles 48.13 23.52 25 28296 1463 4609208
Gastrooesophageal reflux disease 48.06 23.52 65 28256 14828 4595843
Bezoar 48.04 23.52 17 28304 380 4610291
Skin tightness 48.00 23.52 20 28301 704 4609967
Urine albumin/creatinine ratio increased 48.00 23.52 13 28308 113 4610558
Lung disorder 47.76 23.52 59 28262 12312 4598359
Dizziness postural 47.75 23.52 27 28294 1872 4608799
Food interaction 47.51 23.52 18 28303 491 4610180
Implant site extravasation 47.51 23.52 17 28304 393 4610278
Renal ischaemia 47.18 23.52 14 28307 174 4610497
Peripheral ischaemia 47.09 23.52 26 28295 1721 4608950
Hypotonia 46.99 23.52 34 28287 3612 4607059
Sinoatrial block 46.70 23.52 16 28305 324 4610347
Acute coronary syndrome 46.67 23.52 36 28285 4214 4606457
Haemoptysis 46.62 23.52 50 28271 8964 4601707
Lacrimation increased 46.61 23.52 37 28284 4516 4606155
Mouth ulceration 46.54 23.52 42 28279 6108 4604563
Labelled drug-drug interaction medication error 46.35 23.52 32 28289 3156 4607515
Cyanosis 46.12 23.52 42 28279 6180 4604491
Microtia 45.92 23.52 14 28307 192 4610479
Alopecia 45.89 23.52 90 28231 27990 4582681
Kinematic imbalances due to suboccipital strain 45.86 23.52 8 28313 2 4610669
Primary hyperaldosteronism 45.85 23.52 11 28310 55 4610616
Coronary artery stenosis 45.73 23.52 29 28292 2480 4608191
Product label on wrong product 45.69 23.52 11 28310 56 4610615
Hypercholesterolaemia 45.69 23.52 31 28290 2972 4607699
Pulmonary fibrosis 45.69 23.52 40 28281 5590 4605081
Sedation 45.65 23.52 46 28275 7671 4603000
Renal cyst 45.34 23.52 28 28293 2285 4608386
Carotid artery stenosis 45.33 23.52 25 28296 1651 4609020
Foaming at mouth 45.32 23.52 18 28303 559 4610112
Hallucination 45.12 23.52 69 28252 17599 4593072
Arterial occlusive disease 44.95 23.52 24 28297 1486 4609185
Orthopnoea 44.90 23.52 23 28298 1307 4609364
CD30 expression 44.79 23.52 9 28312 15 4610656
Laryngeal oedema 44.74 23.52 28 28293 2340 4608331
Left ventricular failure 44.73 23.52 24 28297 1501 4609170
Mobility decreased 44.71 23.52 59 28262 13146 4597525
Anaphylactic reaction 44.42 23.52 69 28252 17841 4592830
Haematoma 44.39 23.52 51 28270 9865 4600806
Hepatic enzyme increased 44.18 23.52 69 28252 17922 4592749
Scratch 43.79 23.52 23 28298 1377 4609294
Colitis 43.67 23.52 52 28269 10447 4600224
Ventricular hypokinesia 43.65 23.52 23 28298 1386 4609285
Nephropathy 43.63 23.52 26 28295 1990 4608681
Breath sounds abnormal 43.45 23.52 23 28298 1399 4609272
Low density lipoprotein increased 43.40 23.52 28 28293 2467 4608204
Product monitoring error 43.30 23.52 14 28307 235 4610436
Electrocardiogram ST segment elevation 43.28 23.52 24 28297 1602 4609069
Implant site infection 43.14 23.52 18 28303 636 4610035
Alcohol poisoning 43.13 23.52 20 28301 913 4609758
Sensory loss 43.01 23.52 26 28295 2042 4608629
Acute lung injury 42.99 23.52 16 28305 415 4610256
Movement disorder 42.95 23.52 36 28285 4743 4605928
Accidental exposure to product 42.90 23.52 59 28262 13673 4596998
Bundle branch block 42.88 23.52 16 28305 418 4610253
Overweight 42.77 23.52 19 28302 784 4609887
Optic atrophy 42.72 23.52 18 28303 652 4610019
Respiratory tract infection 42.64 23.52 43 28278 7177 4603494
Blood aldosterone increased 42.55 23.52 10 28311 45 4610626
Bowel movement irregularity 42.45 23.52 20 28301 947 4609724
Lymphoedema 42.18 23.52 24 28297 1684 4608987
Hypertonic bladder 41.89 23.52 17 28304 559 4610112
Ventricular hypertrophy 41.89 23.52 23 28298 1506 4609165
Atrial septal defect 41.50 23.52 31 28290 3458 4607213
Gastrointestinal disorder 41.41 23.52 63 28258 15998 4594673
Purpura senile 41.40 23.52 9 28312 26 4610645
Pemphigus 41.39 23.52 20 28301 1002 4609669
Libido decreased 41.27 23.52 25 28296 1971 4608700
Hyperkaliuria 41.16 23.52 8 28313 10 4610661
Optic nerve injury 41.14 23.52 13 28308 202 4610469
Haemorrhagic diathesis 40.92 23.52 21 28300 1198 4609473
Bifascicular block 40.78 23.52 11 28310 94 4610577
Ulcer 40.72 23.52 30 28291 3277 4607394
Lip oedema 40.70 23.52 23 28298 1593 4609078
Troponin increased 40.67 23.52 27 28294 2497 4608174
Muscle necrosis 40.52 23.52 15 28306 383 4610288
Aplastic anaemia 40.39 23.52 24 28297 1827 4608844
Drug dispensed to wrong patient 40.38 23.52 12 28309 150 4610521
Loss of personal independence in daily activities 40.24 23.52 44 28277 8061 4602610
Gastroenteritis 40.20 23.52 37 28284 5518 4605153
Macular degeneration 39.97 23.52 24 28297 1862 4608809
Hypercalcaemia 39.90 23.52 35 28286 4903 4605768
Conjunctival haemorrhage 39.77 23.52 21 28300 1271 4609400
Drug level decreased 39.67 23.52 26 28295 2353 4608318
Micturition urgency 39.61 23.52 25 28296 2120 4608551
Rhinorrhoea 39.53 23.52 53 28268 11989 4598682
Ventricular arrhythmia 39.44 23.52 22 28299 1486 4609185
Left atrial dilatation 39.43 23.52 16 28305 526 4610145
Vitreous floaters 39.37 23.52 23 28298 1696 4608975
Red blood cell count decreased 39.37 23.52 44 28277 8259 4602412
Retching 39.36 23.52 30 28291 3449 4607222
Acute biphenotypic leukaemia 39.35 23.52 9 28312 35 4610636
Femoral artery dissection 39.21 23.52 8 28313 15 4610656
Aortic valve incompetence 39.19 23.52 23 28298 1711 4608960
Cardiovascular disorder 39.17 23.52 37 28284 5703 4604968
Hypocalcaemia 39.15 23.52 43 28278 7918 4602753
Base excess decreased 38.97 23.52 11 28310 113 4610558
Ileus paralytic 38.88 23.52 24 28297 1957 4608714
Arterial stenosis 38.87 23.52 14 28307 330 4610341
Self-medication 38.53 23.52 21 28300 1355 4609316
Liver function test abnormal 38.40 23.52 58 28263 14634 4596037
Neuralgia 38.34 23.52 33 28288 4507 4606164
Rib fracture 38.33 23.52 33 28288 4509 4606162
Splenic rupture 38.32 23.52 17 28304 699 4609972
Reaction to excipient 38.30 23.52 16 28305 567 4610104
Dysgeusia 38.02 23.52 58 28263 14761 4595910
Cutaneous lupus erythematosus 37.97 23.52 18 28303 864 4609807
Ischaemia 37.67 23.52 23 28298 1839 4608832
Conjunctival hyperaemia 37.34 23.52 20 28301 1246 4609425
Hypoalbuminaemia 37.34 23.52 28 28293 3142 4607529
Normochromic normocytic anaemia 37.28 23.52 21 28300 1445 4609226
Purulent discharge 37.23 23.52 21 28300 1449 4609222
Eye oedema 36.98 23.52 16 28305 619 4610052
Eosinophil count increased 36.72 23.52 26 28295 2670 4608001
Parkinson's disease 36.67 23.52 28 28293 3228 4607443
Carotid sinus syndrome 36.58 23.52 8 28313 24 4610647
Sputum discoloured 36.47 23.52 23 28298 1948 4608723
Neutrophil count increased 36.43 23.52 33 28288 4822 4605849
Hallucination, visual 36.42 23.52 36 28285 5866 4604805
Lymphocyte stimulation test positive 36.24 23.52 15 28306 519 4610152
Mixed liver injury 36.20 23.52 16 28305 652 4610019
Asphyxia 36.16 23.52 24 28297 2218 4608453
Disseminated intravascular coagulation 36.12 23.52 40 28281 7433 4603238
Phlebitis 35.98 23.52 23 28298 1994 4608677
Vertigo positional 35.95 23.52 15 28306 530 4610141
Product solubility abnormal 35.92 23.52 14 28307 413 4610258
Hypervolaemia 35.91 23.52 13 28308 311 4610360
Atrial flutter 35.87 23.52 28 28293 3335 4607336
Osteoarthritis 35.78 23.52 45 28276 9559 4601112
Obesity 35.77 23.52 26 28295 2782 4607889
Protein urine present 35.35 23.52 20 28301 1388 4609283
Spinal pain 35.32 23.52 23 28298 2058 4608613
Tooth loss 35.31 23.52 23 28298 2059 4608612
Cranial sutures widening 35.21 23.52 8 28313 30 4610641
Pancytopenia 35.10 23.52 75 28246 24778 4585893
Amylase increased 34.98 23.52 25 28296 2605 4608066
Accidental exposure to product by child 34.94 23.52 21 28300 1632 4609039
Albuminuria 34.93 23.52 11 28310 169 4610502
Hot flush 34.92 23.52 46 28275 10229 4600442
Scar 34.89 23.52 26 28295 2890 4607781
Apnoea 34.84 23.52 27 28294 3181 4607490
Ageusia 34.75 23.52 29 28292 3797 4606874
Blood calcium decreased 34.59 23.52 29 28292 3822 4606849
Inappropriate antidiuretic hormone secretion 34.49 23.52 31 28290 4483 4606188
Inhibitory drug interaction 34.39 23.52 15 28306 592 4610079
Sinus pain 34.31 23.52 12 28309 259 4610412
Necrotising oesophagitis 34.25 23.52 10 28311 117 4610554
Dialysis 34.23 23.52 32 28289 4867 4605804
Intervertebral disc space narrowing 34.23 23.52 11 28310 181 4610490
Lacrimal disorder 34.17 23.52 10 28311 118 4610553
Osmolar gap abnormal 34.01 23.52 7 28314 14 4610657
Cholestatic liver injury 33.99 23.52 15 28306 609 4610062
Choking 33.99 23.52 25 28296 2724 4607947
Extrapyramidal disorder 33.93 23.52 33 28288 5273 4605398
Deep vein thrombosis 33.80 23.52 75 28246 25419 4585252
Ocular hyperaemia 33.79 23.52 36 28285 6404 4604267
Muscle injury 33.79 23.52 15 28306 618 4610053
Cytotoxic oedema 33.78 23.52 9 28312 73 4610598
Breast pain 33.74 23.52 21 28300 1738 4608933
Haematuria 33.61 23.52 51 28270 12919 4597752
Angina unstable 33.57 23.52 28 28293 3664 4607007
Scleral discolouration 33.47 23.52 11 28310 195 4610476
Ventricular hyperkinesia 33.35 23.52 8 28313 40 4610631
Large intestine polyp 33.31 23.52 23 28298 2268 4608403
Organ failure 33.19 23.52 17 28304 966 4609705
Myasthenia gravis 33.03 23.52 19 28302 1361 4609310
Urine flow decreased 33.03 23.52 13 28308 394 4610277
Arteriosclerosis coronary artery 33.00 23.52 26 28295 3138 4607533
Microalbuminuria 32.96 23.52 12 28309 292 4610379
Neuropathy peripheral 32.93 23.52 71 28250 23598 4587073
Normocytic anaemia 32.88 23.52 12 28309 294 4610377
Telangiectasia 32.58 23.52 12 28309 302 4610369
Mitral valve thickening 32.52 23.52 7 28314 19 4610652
Deafness 32.51 23.52 32 28289 5187 4605484
Bronchospasm 32.40 23.52 33 28288 5573 4605098
Tarsal tunnel syndrome 32.26 23.52 8 28313 47 4610624
Nasal congestion 32.21 23.52 45 28276 10581 4600090
Muscle twitching 32.15 23.52 31 28290 4900 4605771
Injury 32.11 23.52 42 28279 9276 4601395
Left atrial enlargement 32.10 23.52 9 28312 90 4610581
Sinus node dysfunction 31.90 23.52 19 28302 1452 4609219
Nikolsky's sign 31.68 23.52 11 28310 232 4610439
Red cell distribution width increased 31.65 23.52 17 28304 1065 4609606
Plasmapheresis 31.61 23.52 10 28311 156 4610515
Night sweats 31.60 23.52 34 28287 6117 4604554
Limb discomfort 31.59 23.52 31 28290 5007 4605664
Dystonia 31.40 23.52 30 28291 4688 4605983
Trigeminal neuralgia 31.34 23.52 16 28305 903 4609768
Heart sounds abnormal 31.31 23.52 12 28309 338 4610333
Hyperplasia 31.11 23.52 12 28309 344 4610327
Hypoinsulinaemia 31.10 23.52 6 28315 7 4610664
Arthropod bite 30.90 23.52 19 28302 1539 4609132
Onychomycosis 30.88 23.52 16 28305 931 4609740
Cardiorenal syndrome 30.87 23.52 10 28311 169 4610502
Forced vital capacity decreased 30.81 23.52 10 28311 170 4610501
Haemangioma congenital 30.75 23.52 11 28310 254 4610417
Posterior reversible encephalopathy syndrome 30.72 23.52 29 28292 4466 4606205
Foot deformity 30.67 23.52 23 28298 2580 4608091
Jaundice cholestatic 30.53 23.52 19 28302 1572 4609099
Dilatation ventricular 30.49 23.52 17 28304 1147 4609524
Skin abrasion 30.27 23.52 21 28300 2087 4608584
Congenital spinal cord anomaly 30.25 23.52 7 28314 29 4610642
Cardiac dysfunction 30.14 23.52 12 28309 375 4610296
Immune thrombocytopenic purpura 30.13 23.52 25 28296 3247 4607424
Creatinine renal clearance decreased 30.09 23.52 20 28301 1853 4608818
Haematemesis 29.99 23.52 40 28281 9003 4601668
Gastric ulcer 29.98 23.52 33 28288 6090 4604581
Hypertrophy 29.88 23.52 10 28311 188 4610483
Panic reaction 29.83 23.52 17 28304 1196 4609475
Blood loss anaemia 29.82 23.52 21 28300 2137 4608534
Lip disorder 29.79 23.52 12 28309 387 4610284
Bromhidrosis 29.78 23.52 5 28316 0 4610671
Patent ductus arteriosus 29.64 23.52 19 28302 1655 4609016
Femoral neck fracture 29.52 23.52 20 28301 1912 4608759
Anosmia 29.48 23.52 18 28303 1439 4609232
Cleft palate 29.45 23.52 14 28307 676 4609995
Caesarean section 29.44 23.52 30 28291 5068 4605603
Withdrawal hypertension 29.39 23.52 8 28313 71 4610600
Blood pH decreased 29.27 23.52 16 28305 1038 4609633
Pupil fixed 29.22 23.52 15 28306 856 4609815
Rhinitis 29.00 23.52 20 28301 1969 4608702
Coarctation of the aorta 28.97 23.52 12 28309 416 4610255
Renal artery thrombosis 28.84 23.52 9 28312 134 4610537
Dermatosis 28.76 23.52 10 28311 212 4610459
Skin plaque 28.73 23.52 21 28300 2266 4608405
Kidney small 28.63 23.52 8 28313 79 4610592
Infarction 28.52 23.52 18 28303 1526 4609145
Skin burning sensation 28.36 23.52 23 28298 2893 4607778
Blood triglycerides increased 28.35 23.52 30 28291 5295 4605376
Torticollis 28.34 23.52 14 28307 736 4609935
Dysphonia 28.30 23.52 42 28279 10432 4600239
Facial paresis 28.25 23.52 16 28305 1113 4609558
Dermatitis bullous 28.15 23.52 23 28298 2924 4607747
Listless 28.06 23.52 14 28307 752 4609919
Blood albumin decreased 27.97 23.52 25 28296 3589 4607082
Respiratory acidosis 27.72 23.52 18 28303 1603 4609068
Aortic dissection 27.70 23.52 15 28306 955 4609716
Gingival disorder 27.66 23.52 15 28306 958 4609713
Gastric disorder 27.59 23.52 31 28290 5851 4604820
High density lipoprotein decreased 27.59 23.52 16 28305 1164 4609507
Road traffic accident 27.58 23.52 37 28284 8372 4602299
Lymphomatoid papulosis 27.57 23.52 9 28312 156 4610515
Right atrial enlargement 27.56 23.52 7 28314 46 4610625
Dry eye 27.54 23.52 30 28291 5471 4605200
Ear discomfort 27.43 23.52 18 28303 1632 4609039
Stasis dermatitis 27.40 23.52 10 28311 245 4610426
Papule 27.34 23.52 18 28303 1641 4609030
Rectal haemorrhage 27.23 23.52 45 28276 12251 4598420
Poor peripheral circulation 27.23 23.52 14 28307 802 4609869
Thirst 27.16 23.52 23 28298 3073 4607598
Dermatitis allergic 27.15 23.52 24 28297 3396 4607275
Stenosis 27.14 23.52 10 28311 252 4610419
Wound dehiscence 27.10 23.52 17 28304 1426 4609245
Congenital anomaly 27.05 23.52 20 28301 2196 4608475
Duodenal ulcer 26.94 23.52 23 28298 3107 4607564
Multiple drug therapy 26.77 23.52 8 28313 102 4610569
Osteoporosis 26.73 23.52 32 28289 6463 4604208
Thrombocytopenic purpura 26.63 23.52 13 28308 666 4610005
Blood immunoglobulin E increased 26.58 23.52 13 28308 669 4610002
Hypospadias 26.53 23.52 14 28307 846 4609825
Oedema mouth 26.53 23.52 16 28305 1251 4609420
Respiratory rate decreased 26.53 23.52 15 28306 1040 4609631
Bile duct stone 26.50 23.52 15 28306 1042 4609629
Rash papular 26.39 23.52 27 28294 4584 4606087
Arterial disorder 26.35 23.52 12 28309 525 4610146
Blood calcium increased 26.34 23.52 19 28302 2008 4608663
Sprue-like enteropathy 26.27 23.52 13 28308 686 4609985
Hypoventilation 26.04 23.52 16 28305 1294 4609377
Gangrene 26.00 23.52 17 28304 1532 4609139
Protein total decreased 25.98 23.52 17 28304 1534 4609137
Oxygen consumption decreased 25.95 23.52 8 28313 114 4610557
Procedural failure 25.84 23.52 5 28316 6 4610665
Serotonin syndrome 25.83 23.52 33 28288 7119 4603552
Diabetic retinopathy 25.79 23.52 13 28308 714 4609957
Arrhythmia supraventricular 25.79 23.52 12 28309 552 4610119
Gastrointestinal tract mucosal pigmentation 25.73 23.52 7 28314 62 4610609
Blepharospasm 25.70 23.52 14 28307 902 4609769
Hypertensive encephalopathy 25.63 23.52 10 28311 296 4610375
Genital rash 25.63 23.52 10 28311 296 4610375
Gastric varices haemorrhage 25.58 23.52 8 28313 120 4610551
Blood chloride decreased 25.57 23.52 16 28305 1336 4609335
Dementia 25.45 23.52 28 28293 5164 4605507
Cardiac hypertrophy 25.44 23.52 11 28310 425 4610246
5-hydroxyindolacetic acid in urine increased 25.41 23.52 5 28316 7 4610664
Paraplegia 25.37 23.52 15 28306 1131 4609540
Brain oedema 25.36 23.52 27 28294 4800 4605871
Choking sensation 25.34 23.52 15 28306 1134 4609537
Tenderness 25.33 23.52 22 28299 3041 4607630
Dysstasia 25.26 23.52 27 28294 4820 4605851
Lip erosion 25.25 23.52 10 28311 308 4610363
Drug level above therapeutic 25.15 23.52 15 28306 1149 4609522
Wrong technique in product usage process 24.99 23.52 80 28241 33694 4576977
Needle issue 24.93 23.52 18 28303 1905 4608766
Herbal interaction 24.87 23.52 8 28313 132 4610539
Bronchial hyperreactivity 24.85 23.52 11 28310 450 4610221
Hypothyroidism 24.84 23.52 34 28287 7840 4602831
Procedural hypotension 24.78 23.52 11 28310 453 4610218
Bladder catheterisation 24.64 23.52 9 28312 221 4610450
Anion gap 24.64 23.52 9 28312 221 4610450
Liver injury 24.64 23.52 27 28294 4958 4605713
Anion gap increased 24.60 23.52 12 28309 614 4610057
Cerebral haematoma 24.45 23.52 16 28305 1444 4609227
Bradyarrhythmia 24.42 23.52 13 28308 800 4609871
Miosis 24.39 23.52 21 28300 2869 4607802
Nodal arrhythmia 24.38 23.52 11 28310 471 4610200
Lichenoid keratosis 24.33 23.52 13 28308 806 4609865
Faecaloma 24.31 23.52 17 28304 1711 4608960
Hypochromasia 24.12 23.52 7 28314 80 4610591
Haemorrhage 24.10 23.52 66 28255 25496 4585175
Multiple fractures 24.09 23.52 14 28307 1022 4609649
Essential hypertension 24.09 23.52 13 28308 822 4609849
Epilepsy 24.06 23.52 37 28284 9481 4601190
Cardiac septal hypertrophy 24.04 23.52 7 28314 81 4610590
Retinal ischaemia 24.02 23.52 9 28312 238 4610433
Musculoskeletal discomfort 24.00 23.52 22 28299 3264 4607407
Arteriospasm coronary 24.00 23.52 16 28305 1490 4609181
Pelvic fracture 23.96 23.52 17 28304 1751 4608920
Abdominal hernia 23.94 23.52 14 28307 1034 4609637
Anosognosia 23.92 23.52 8 28313 150 4610521
Forced expiratory volume decreased 23.91 23.52 14 28307 1037 4609634
Potentiating drug interaction 23.85 23.52 16 28305 1505 4609166
Muscle disorder 23.84 23.52 16 28305 1506 4609165
Fibromuscular dysplasia 23.81 23.52 6 28315 38 4610633
Respiratory tract haemorrhage 23.81 23.52 9 28312 244 4610427
Cleft lip and palate 23.76 23.52 11 28310 500 4610171
Lacunar infarction 23.75 23.52 15 28306 1273 4609398
Anger 23.60 23.52 28 28293 5601 4605070
Cardiac tamponade 23.60 23.52 18 28303 2071 4608600
Foreign body 23.52 23.52 13 28308 862 4609809

Pharmacologic Action:

SourceCodeDescription
ATC C08CA01 CARDIOVASCULAR SYSTEM
CALCIUM CHANNEL BLOCKERS
SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS
Dihydropyridine derivatives
ATC C07FB07 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS, OTHER COMBINATIONS
Beta blocking agents and calcium channel blockers
ATC C07FB12 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS, OTHER COMBINATIONS
Beta blocking agents and calcium channel blockers
ATC C07FB13 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS, OTHER COMBINATIONS
Beta blocking agents and calcium channel blockers
ATC C08CA51 CARDIOVASCULAR SYSTEM
CALCIUM CHANNEL BLOCKERS
SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS
Dihydropyridine derivatives
ATC C08GA02 CARDIOVASCULAR SYSTEM
CALCIUM CHANNEL BLOCKERS
CALCIUM CHANNEL BLOCKERS AND DIURETICS
Calcium channel blockers and diuretics
ATC C09BB03 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, COMBINATIONS
ACE inhibitors and calcium channel blockers
ATC C09BB04 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, COMBINATIONS
ACE inhibitors and calcium channel blockers
ATC C09BB07 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, COMBINATIONS
ACE inhibitors and calcium channel blockers
ATC C09BX01 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, COMBINATIONS
ACE inhibitors, other combinations
ATC C09BX03 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, COMBINATIONS
ACE inhibitors, other combinations
ATC C09BX04 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, COMBINATIONS
ACE inhibitors, other combinations
ATC C09DB01 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS
Angiotensin II receptor blockers (ARBs) and calcium channel blockers
ATC C09DB02 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS
Angiotensin II receptor blockers (ARBs) and calcium channel blockers
ATC C09DB04 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS
Angiotensin II receptor blockers (ARBs) and calcium channel blockers
ATC C09DB05 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS
Angiotensin II receptor blockers (ARBs) and calcium channel blockers
ATC C09DB06 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS
Angiotensin II receptor blockers (ARBs) and calcium channel blockers
ATC C09DB07 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS
Angiotensin II receptor blockers (ARBs) and calcium channel blockers
ATC C09DB09 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS
Angiotensin II receptor blockers (ARBs) and calcium channel blockers
ATC C09DX01 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS
Angiotensin II receptor blockers (ARBs), other combinations
ATC C09DX03 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS
Angiotensin II receptor blockers (ARBs), other combinations
ATC C09DX06 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS
Angiotensin II receptor blockers (ARBs), other combinations
ATC C09DX07 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS
Angiotensin II receptor blockers (ARBs), other combinations
ATC C09XA53 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
OTHER AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
Renin-inhibitors
ATC C09XA54 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
OTHER AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
Renin-inhibitors
ATC C10BX03 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
HMG CoA reductase inhibitors, other combinations
ATC C10BX07 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
HMG CoA reductase inhibitors, other combinations
ATC C10BX09 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
HMG CoA reductase inhibitors, other combinations
ATC C10BX11 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
HMG CoA reductase inhibitors, other combinations
ATC C10BX14 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
HMG CoA reductase inhibitors, other combinations
FDA MoA N0000000069 Calcium Channel Antagonists
FDA EPC N0000175421 Dihydropyridine Calcium Channel Blocker
FDA CS M0006414 Dihydropyridines
MeSH PA D000959 Antihypertensive Agents
MeSH PA D002121 Calcium Channel Blockers
MeSH PA D000077264 Calcium-Regulating Hormones and Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D049990 Membrane Transport Modulators
CHEBI has role CHEBI:35674 antihypertensive agent
CHEBI has role CHEBI:35620 vasodilator agent
MeSH PA D014665 Vasodilator Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Hypertensive disorder indication 38341003 DOID:10763
Prinzmetal angina indication 87343002
Angina pectoris indication 194828000
Cerebrovascular accident indication 230690007
Primary Prevention of Coronary Heart Disease indication
Myocardial Infarction Prevention indication
Anuria contraindication 2472002 DOID:2983
Alcoholism contraindication 7200002
Hyperkalemia contraindication 14140009
Jaundice contraindication 18165001
Secondary angle-closure glaucoma contraindication 21571006
Hypovolemia contraindication 28560003
Obstruction of bile duct contraindication 30144000
Dehydration contraindication 34095006
Hyperuricemia contraindication 35885006 DOID:1920
Hypothyroidism contraindication 40930008 DOID:1459
Angioedema contraindication 41291007 DOID:1558
Hypokalemia contraindication 43339004
Diabetes mellitus type 2 contraindication 44054006 DOID:9352
Low blood pressure contraindication 45007003
Systemic lupus erythematosus contraindication 55464009 DOID:9074
Sympathectomy contraindication 57071006
Acute nephropathy contraindication 58574008
Hepatic failure contraindication 59927004
Hypercalcemia contraindication 66931009 DOID:12678
Hyperparathyroidism contraindication 66999008 DOID:13543
Hypochloremic alkalosis contraindication 70134007
Hepatic coma contraindication 72836002 DOID:12550
Diabetes mellitus contraindication 73211009 DOID:9351
Chronic idiopathic constipation contraindication 82934008
Hereditary angioneurotic edema contraindication 82966003 DOID:14735
Hyponatremia contraindication 89627008
Gout contraindication 90560007 DOID:13189
Kidney disease contraindication 90708001 DOID:557
Disorder of connective tissue contraindication 105969002 DOID:65
Disorder of muscle contraindication 129565002 DOID:423
Liver function tests abnormal contraindication 166603001
Hypomagnesemia contraindication 190855004
Acute pancreatitis contraindication 197456007 DOID:2913
Impaired renal function disorder contraindication 197663003
Hemorrhagic cerebral infarction contraindication 230706003
Disease of liver contraindication 235856003 DOID:409
Rhabdomyolysis contraindication 240131006
Neonatal hyperbilirubinemia contraindication 281610001
Pregnancy, function contraindication 289908002
Renal artery stenosis contraindication 302233006
Neutropenic disorder contraindication 303011007 DOID:1227
Bone marrow depression contraindication 307762000
Surgical procedure contraindication 387713003
Breastfeeding (mother) contraindication 413712001
Traumatic injury contraindication 417746004
Azotemia contraindication 445009001
Head and Neck Angioedema contraindication
Hemodialysis with High-Flux Membrane contraindication
Severe Aortic Valve Stenosis contraindication
Intestinal Angioedema contraindication

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.0 Basic
pKa2 1.55 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
EQ 10MG BASE PRESTALIA ADHERA N205003 Jan. 21, 2015 RX TABLET ORAL 6696481 April 15, 2023 TREATMENT OF HYPERTENSION
EQ 2.5MG BASE PRESTALIA ADHERA N205003 Jan. 21, 2015 RX TABLET ORAL 6696481 April 15, 2023 TREATMENT OF HYPERTENSION
EQ 5MG BASE PRESTALIA ADHERA N205003 Jan. 21, 2015 RX TABLET ORAL 6696481 April 15, 2023 TREATMENT OF HYPERTENSION
EQ 10MG BASE CONSENSI COEPTIS N210045 May 31, 2018 RX TABLET ORAL 9662315 May 22, 2029 TREATMENT OF ADULT PATIENTS FOR WHOM TREATMENT WITH BOTH AMLODIPINE FOR HYPERTENSION AND CELECOXIB FOR OSTEOARTHRITIS ARE APPROPRIATE
EQ 2.5MG BASE CONSENSI COEPTIS N210045 May 31, 2018 RX TABLET ORAL 9662315 May 22, 2029 TREATMENT OF ADULT PATIENTS FOR WHOM TREATMENT WITH BOTH AMLODIPINE FOR HYPERTENSION AND CELECOXIB FOR OSTEOARTHRITIS ARE APPROPRIATE
EQ 5MG BASE CONSENSI COEPTIS N210045 May 31, 2018 RX TABLET ORAL 9662315 May 22, 2029 TREATMENT OF ADULT PATIENTS FOR WHOM TREATMENT WITH BOTH AMLODIPINE FOR HYPERTENSION AND CELECOXIB FOR OSTEOARTHRITIS ARE APPROPRIATE
EQ 10MG BASE PRESTALIA ADHERA N205003 Jan. 21, 2015 RX TABLET ORAL 7846961 Oct. 5, 2029 TREATMENT OF HYPERTENSION
EQ 2.5MG BASE PRESTALIA ADHERA N205003 Jan. 21, 2015 RX TABLET ORAL 7846961 Oct. 5, 2029 TREATMENT OF HYPERTENSION
EQ 5MG BASE PRESTALIA ADHERA N205003 Jan. 21, 2015 RX TABLET ORAL 7846961 Oct. 5, 2029 TREATMENT OF HYPERTENSION

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
EQ 10MG BASE CONSENSI COEPTIS N210045 May 31, 2018 RX TABLET ORAL May 31, 2021 NEW COMBINATION
EQ 2.5MG BASE CONSENSI COEPTIS N210045 May 31, 2018 RX TABLET ORAL May 31, 2021 NEW COMBINATION
EQ 5MG BASE CONSENSI COEPTIS N210045 May 31, 2018 RX TABLET ORAL May 31, 2021 NEW COMBINATION

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Voltage-dependent L-type calcium channel subunit alpha-1D Ion channel BLOCKER Ki 7 WOMBAT-PK CHEMBL
Voltage-dependent L-type calcium channel subunit alpha-1C Ion channel BLOCKER WOMBAT-PK CHEMBL
Voltage-dependent calcium channel gamma-1 subunit Ion channel Ki 7.20 WOMBAT-PK
Alpha-2A adrenergic receptor GPCR Ki 6.65 DRUG MATRIX
5-hydroxytryptamine receptor 6 GPCR Ki 5.87 DRUG MATRIX
Alpha-2C adrenergic receptor GPCR Ki 6.58 DRUG MATRIX
Sodium-dependent dopamine transporter Transporter Ki 5.36 DRUG MATRIX
Carbonic anhydrase 1 Enzyme WOMBAT-PK
Aldehyde oxidase Enzyme IC50 5.26 WOMBAT-PK
Voltage-dependent T-type calcium channel subunit alpha-1H Ion channel Ki 4.51 WOMBAT-PK
Alpha-1D adrenergic receptor GPCR Ki 5.27 CHEMBL
Potassium channel subfamily K member 2 Ion channel IC50 6.40 CHEMBL
Alpha-1A adrenergic receptor GPCR Ki 5.63 CHEMBL
Alpha-1B adrenergic receptor GPCR Ki 5.10 CHEMBL
Voltage-dependent calcium channel subunit alpha-2/delta-1 Ion channel Ki 7.20 WOMBAT-PK
Voltage-dependent L-type calcium channel subunit alpha-1C Ion channel Ki 8.70 CHEMBL

External reference:

IDSource
4020813 VUID
N0000148333 NUI
C0051696 UMLSCUI
D00615 KEGG_DRUG
1J444QC288 UNII
5729 INN_ID
246852-12-0 SECONDARY_CAS_RN
108537001 SNOMEDCT_US
4020813 VANDF
27341 MMSL
003672 NDDF
17767 RXNORM
d00689 MMSL
386864001 SNOMEDCT_US
173594 MMSL
CHEMBL1491 ChEMBL_ID
DB00381 DRUGBANK_ID
CHEMBL1200402 ChEMBL_ID
06X PDB_CHEM_ID
6UB PDB_CHEM_ID
CHEBI:2668 CHEBI
6981 IUPHAR_LIGAND_ID
CHEMBL1200984 ChEMBL_ID
D017311 MESH_DESCRIPTOR_UI
2162 PUBCHEM_CID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Amlodipine Besylate HUMAN PRESCRIPTION DRUG LABEL 1 0054-0100 TABLET 2.50 mg ORAL ANDA 16 sections
Amlodipine Besylate HUMAN PRESCRIPTION DRUG LABEL 1 0054-0101 TABLET 5 mg ORAL ANDA 16 sections
Amlodipine Besylate HUMAN PRESCRIPTION DRUG LABEL 1 0054-0102 TABLET 10 mg ORAL ANDA 16 sections
Norvasc HUMAN PRESCRIPTION DRUG LABEL 1 0069-1520 TABLET 2.50 mg ORAL NDA 17 sections
Norvasc HUMAN PRESCRIPTION DRUG LABEL 1 0069-1530 TABLET 5 mg ORAL NDA 17 sections
Norvasc HUMAN PRESCRIPTION DRUG LABEL 1 0069-1540 TABLET 10 mg ORAL NDA 17 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2150 TABLET, FILM COATED 5 mg ORAL NDA 19 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2160 TABLET, FILM COATED 10 mg ORAL NDA 19 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2170 TABLET, FILM COATED 5 mg ORAL NDA 19 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2180 TABLET, FILM COATED 10 mg ORAL NDA 19 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2190 TABLET, FILM COATED 5 mg ORAL NDA 19 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2250 TABLET, FILM COATED 10 mg ORAL NDA 19 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2260 TABLET, FILM COATED 5 mg ORAL NDA 19 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2270 TABLET, FILM COATED 10 mg ORAL NDA 19 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2960 TABLET, FILM COATED 2.50 mg ORAL NDA 19 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2970 TABLET, FILM COATED 2.50 mg ORAL NDA 19 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2980 TABLET, FILM COATED 2.50 mg ORAL NDA 19 sections
Lotrel HUMAN PRESCRIPTION DRUG LABEL 2 0078-0364 CAPSULE 10 mg ORAL NDA 18 sections
Lotrel HUMAN PRESCRIPTION DRUG LABEL 2 0078-0379 CAPSULE 10 mg ORAL NDA 18 sections
Lotrel HUMAN PRESCRIPTION DRUG LABEL 2 0078-0405 CAPSULE 5 mg ORAL NDA 18 sections
Lotrel HUMAN PRESCRIPTION DRUG LABEL 2 0078-0406 CAPSULE 5 mg ORAL NDA 18 sections
Exforge HUMAN PRESCRIPTION DRUG LABEL 2 0078-0488 TABLET, FILM COATED 5 mg ORAL NDA 18 sections
Exforge HUMAN PRESCRIPTION DRUG LABEL 2 0078-0489 TABLET, FILM COATED 10 mg ORAL NDA 18 sections
Exforge HUMAN PRESCRIPTION DRUG LABEL 2 0078-0490 TABLET, FILM COATED 5 mg ORAL NDA 18 sections
Exforge HUMAN PRESCRIPTION DRUG LABEL 2 0078-0491 TABLET, FILM COATED 10 mg ORAL NDA 18 sections
Exforge HCT HUMAN PRESCRIPTION DRUG LABEL 3 0078-0559 TABLET, FILM COATED 5 mg ORAL NDA 18 sections
Exforge HCT HUMAN PRESCRIPTION DRUG LABEL 3 0078-0560 TABLET, FILM COATED 5 mg ORAL NDA 18 sections
Exforge HCT HUMAN PRESCRIPTION DRUG LABEL 3 0078-0561 TABLET, FILM COATED 10 mg ORAL NDA 18 sections
Exforge HCT HUMAN PRESCRIPTION DRUG LABEL 3 0078-0562 TABLET, FILM COATED 10 mg ORAL NDA 18 sections
Exforge HCT HUMAN PRESCRIPTION DRUG LABEL 3 0078-0563 TABLET, FILM COATED 10 mg ORAL NDA 18 sections