amlodipine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
calcium channel blockers, nifedipine derivatives 183 88150-42-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • amlodipine
  • amlopres
  • racemic amlodipine
  • amlodipine besylate
  • amlodipine besilate
  • amlodipine maleate
  • amlodipine mesylate
  • amlodipine mesilate
A long-acting dihydropyridine calcium channel blocker. It is effective in the treatment of ANGINA PECTORIS and HYPERTENSION.
  • Molecular weight: 408.88
  • Formula: C20H25ClN2O5
  • CLOGP: 3.43
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 2
  • TPSA: 99.88
  • ALOGS: -4.74
  • ROTB: 10
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
5 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 10 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 0.35 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 74 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 17 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 7 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.01 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 34 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
July 31, 1992 FDA PFIZER

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pemphigus 1110.72 10.01 37 441248 183689 62864048
Drug ineffective 1041.65 10.01 3759 437526 1041006 62006731
Systemic lupus erythematosus 902.32 10.01 178 441107 208740 62838997
Glossodynia 877.78 10.01 106 441179 178770 62868967
Hand deformity 871.68 10.01 61 441224 159396 62888341
Maternal exposure during pregnancy 863.81 10.01 231 441054 219831 62827906
Completed suicide 858.88 10.01 2591 438694 143082 62904655
Contraindicated product administered 853.30 10.01 229 441056 217419 62830318
Hypotension 798.06 10.01 3877 437408 268727 62779010
Anti-cyclic citrullinated peptide antibody positive 758.99 10.01 9 441276 116203 62931534
Synovitis 726.32 10.01 200 441085 186718 62861019
Pericarditis 694.67 10.01 59 441226 131520 62916217
Treatment failure 678.64 10.01 267 441018 198776 62848961
Drug intolerance 657.04 10.01 706 440579 307955 62739782
Arthropathy 653.13 10.01 413 440872 234379 62813358
Infusion related reaction 616.84 10.01 482 440803 245039 62802698
Therapeutic product effect decreased 600.42 10.01 296 440989 192891 62854846
Acute kidney injury 584.44 10.01 3473 437812 259942 62787795
Wound 583.40 10.01 203 441082 163060 62884677
Alopecia 575.65 10.01 911 440374 336625 62711112
Duodenal ulcer perforation 505.04 10.01 24 441261 87185 62960552
Off label use 501.63 10.01 2702 438583 671760 62375977
Hyponatraemia 500.34 10.01 1813 439472 110087 62937650
Discomfort 463.07 10.01 296 440989 167078 62880659
Helicobacter infection 462.38 10.01 52 441233 92733 62955004
Shock 448.61 10.01 676 440609 22787 63024950
Blood pressure increased 436.68 10.01 2253 439032 159809 62887928
Gingival hypertrophy 424.12 10.01 215 441070 1456 63046281
Hepatic enzyme increased 422.18 10.01 470 440815 201858 62845879
Folliculitis 421.74 10.01 15 441270 70302 62977435
Fall 420.84 10.01 4370 436915 387964 62659773
Blood pressure inadequately controlled 413.23 10.01 314 440971 4664 63043073
Hypersensitivity 396.93 10.01 906 440379 291779 62755958
Oedema peripheral 381.62 10.01 2438 438847 187073 62860664
Exposure during pregnancy 377.12 10.01 316 440969 155231 62892506
Rheumatoid factor positive 376.78 10.01 66 441219 84340 62963397
Orthostatic hypotension 364.12 10.01 788 440497 35372 63012365
Cerebrovascular accident 359.15 10.01 1596 439689 106428 62941309
Bradycardia 356.09 10.01 1220 440065 72007 62975730
Abdominal discomfort 345.82 10.01 1112 440173 319773 62727964
Rheumatoid arthritis 338.16 10.01 793 440492 253026 62794711
Muscle injury 337.50 10.01 32 441253 65313 62982424
Product use issue 335.58 10.01 639 440646 219881 62827856
Swelling 332.32 10.01 905 440380 274473 62773264
Non-cardiogenic pulmonary oedema 329.36 10.01 140 441145 591 63047146
Sleep disorder due to general medical condition, insomnia type 324.56 10.01 8 441277 52209 62995528
Toxicity to various agents 311.66 10.01 2850 438435 244400 62803337
Vasoplegia syndrome 297.89 10.01 171 441114 1528 63046209
Renal impairment 286.57 10.01 1296 439989 87059 62960678
C-reactive protein abnormal 282.98 10.01 8 441277 46088 63001649
Impaired healing 271.84 10.01 190 441095 102352 62945385
Irritable bowel syndrome 270.21 10.01 117 441168 82295 62965442
Pain 267.41 10.01 3588 437697 737040 62310697
Lactic acidosis 266.98 10.01 724 440561 37563 63010174
Hyperkalaemia 246.14 10.01 883 440402 53320 62994417
Intentional overdose 242.93 10.01 1091 440194 73061 62974676
Lower respiratory tract infection 232.84 10.01 349 440936 131958 62915779
Metabolic acidosis 220.01 10.01 752 440533 44317 63003420
Infection 219.24 10.01 835 440450 228338 62819399
Joint swelling 214.14 10.01 1366 439919 326300 62721437
Dizziness 210.43 10.01 4173 437112 425752 62621985
Depressed level of consciousness 208.33 10.01 920 440365 61158 62986579
Creatinine renal clearance decreased 207.83 10.01 392 440893 15916 63031821
Angioedema 206.49 10.01 768 440517 47197 63000540
Ill-defined disorder 200.63 10.01 164 441121 81591 62966146
Sinusitis 197.21 10.01 857 440428 225796 62821941
Balance disorder 196.32 10.01 1128 440157 83294 62964443
Therapeutic product effect incomplete 195.72 10.01 356 440929 124700 62923037
Hypokalaemia 193.84 10.01 1311 439974 102493 62945244
Arthralgia 193.39 10.01 2793 438492 566917 62480820
Musculoskeletal stiffness 187.50 10.01 656 440629 183962 62863775
Psoriatic arthropathy 187.01 10.01 216 441069 91304 62956433
Fibromyalgia 185.60 10.01 171 441114 80249 62967488
Distributive shock 182.53 10.01 116 441169 1267 63046470
Cardiac failure congestive 178.36 10.01 1177 440108 91256 62956481
Sedation complication 175.83 10.01 332 440953 13490 63034247
Condition aggravated 172.63 10.01 1875 439410 400342 62647395
Pregnancy 168.36 10.01 27 441258 36809 63010928
Hypoglycaemia 167.08 10.01 843 440442 59222 62988515
Abortion spontaneous 162.82 10.01 62 441223 47133 63000604
Intentional product use issue 160.36 10.01 412 440873 127480 62920257
Blood creatinine increased 154.86 10.01 1094 440191 86750 62960987
Atrial fibrillation 153.08 10.01 1357 439928 115279 62932458
Gastrointestinal disorder 148.75 10.01 444 440841 130795 62916942
Hypertensive crisis 148.04 10.01 328 440957 14958 63032779
Drug interaction 147.50 10.01 2324 438961 226807 62820930
Rash 146.97 10.01 2882 438403 557989 62489748
Myocardial infarction 145.75 10.01 1190 440095 98703 62949034
Renal failure 145.34 10.01 1351 439934 116301 62931436
Blister 144.39 10.01 443 440842 129371 62918366
Stomatitis 144.15 10.01 488 440797 138237 62909500
Device expulsion 143.93 10.01 33 441252 34889 63012848
Hip arthroplasty 141.91 10.01 77 441208 47569 63000168
Neurologic neglect syndrome 133.78 10.01 127 441158 2594 63045143
Injection site reaction 129.71 10.01 129 441156 58395 62989342
Blood calcium decreased 129.64 10.01 442 440843 26009 63021728
Carotid artery thrombosis 123.48 10.01 123 441162 2671 63045066
Dehydration 123.40 10.01 1789 439496 171565 62876172
Syncope 119.89 10.01 1296 439989 116089 62931648
Cognitive disorder 119.57 10.01 730 440555 55085 62992652
Live birth 118.91 10.01 18 441267 25612 63022125
Overdose 118.67 10.01 1273 440012 113805 62933932
Decreased appetite 117.57 10.01 2422 438863 248630 62799107
Asthenia 116.63 10.01 3490 437795 380114 62667623
Swollen tongue 114.65 10.01 513 440772 34287 63013450
Palpitations 111.00 10.01 1236 440049 111534 62936203
Cerebral infarction 110.80 10.01 392 440893 23501 63024236
Drug level increased 106.28 10.01 374 440911 22362 63025375
Liver injury 106.07 10.01 160 441125 60360 62987377
Rhabdomyolysis 105.91 10.01 593 440692 43358 63004379
Anuria 105.79 10.01 255 441030 12296 63035441
Product use in unapproved indication 105.64 10.01 769 440516 178311 62869426
Hemiplegia 105.29 10.01 213 441072 9110 63038627
Cardiac failure 104.28 10.01 1012 440273 88130 62959607
Drug abuse 104.26 10.01 217 441068 72301 62975436
Blood pressure decreased 102.71 10.01 789 440496 64233 62983504
Schizoaffective disorder 100.55 10.01 124 441161 3438 63044299
Coronary artery disease 100.51 10.01 469 440816 31908 63015829
Type 2 diabetes mellitus 99.72 10.01 182 441103 63686 62984051
Injection site erythema 98.89 10.01 275 441010 82899 62964838
Knee arthroplasty 98.23 10.01 140 441145 54066 62993671
Circulatory collapse 96.69 10.01 354 440931 21584 63026153
Atrioventricular block complete 96.16 10.01 191 441094 8060 63039677
Adjustment disorder 95.19 10.01 114 441171 3064 63044673
Angina pectoris 94.33 10.01 437 440848 29641 63018096
Chronic kidney disease 93.62 10.01 588 440697 44810 63002927
Sprue-like enteropathy 92.32 10.01 60 441225 683 63047054
Sinus bradycardia 89.51 10.01 263 441022 14288 63033449
Injury 89.46 10.01 239 441046 73008 62974729
Sedation 88.51 10.01 516 440769 38293 63009444
Acute myocardial infarction 88.01 10.01 449 440836 31675 63016062
Product prescribing error 87.70 10.01 389 440896 25900 63021837
Pulmonary oedema 87.31 10.01 667 440618 54206 62993531
Pyrexia 86.94 10.01 2548 438737 467930 62579807
Dysarthria 86.71 10.01 551 440734 42160 63005577
Dyspnoea 86.43 10.01 5511 435774 655802 62391935
Blood urea increased 85.50 10.01 387 440898 25992 63021745
Hypertensive emergency 85.30 10.01 84 441201 1798 63045939
Hypomagnesaemia 83.92 10.01 409 440876 28328 63019409
Blood cholesterol increased 82.62 10.01 354 440931 93678 62954059
Prescribed overdose 80.72 10.01 71 441214 34082 63013655
Personality disorder 79.46 10.01 144 441141 5667 63042070
Renin increased 77.08 10.01 34 441251 160 63047577
Proteinuria 76.98 10.01 300 440985 18845 63028892
Injection site pain 76.22 10.01 558 440727 129242 62918495
Subacute cutaneous lupus erythematosus 76.21 10.01 93 441192 2550 63045187
Cardiogenic shock 75.38 10.01 285 441000 17647 63030090
Constipation 74.40 10.01 2069 439216 222874 62824863
Anaemia 73.12 10.01 2608 438677 290822 62756915
Transient ischaemic attack 72.94 10.01 481 440804 37272 63010465
Suspected suicide 72.92 10.01 149 441136 6419 63041318
Blood pressure systolic increased 72.56 10.01 571 440714 46826 63000911
Atrioventricular block first degree 71.49 10.01 157 441128 7116 63040621
Migraine 70.89 10.01 424 440861 102922 62944815
Hyperglycaemia 70.04 10.01 515 440770 41352 63006385
Intentional self-injury 68.83 10.01 47 441238 25640 63022097
Facet joint syndrome 68.18 10.01 4 441281 12134 63035603
Foetal exposure during pregnancy 67.94 10.01 73 441212 31889 63015848
Hepatic function abnormal 66.84 10.01 465 440820 36677 63011060
Deep vein thrombosis postoperative 66.21 10.01 3 441282 11366 63036371
Atrioventricular block 66.21 10.01 157 441128 7490 63040247
Oliguria 65.33 10.01 174 441111 8927 63038810
Left ventricular hypertrophy 64.32 10.01 125 441160 5190 63042547
Blood glucose increased 63.81 10.01 875 440410 82881 62964856
Diabetes mellitus inadequate control 62.43 10.01 239 441046 14887 63032850
Grip strength decreased 60.76 10.01 40 441245 22247 63025490
Hypertension 60.62 10.01 2445 438840 276858 62770879
Nasopharyngitis 58.85 10.01 1332 439953 252925 62794812
Lung diffusion test abnormal 58.74 10.01 34 441251 309 63047428
Bursitis 58.31 10.01 105 441180 36936 63010801
Loss of consciousness 57.99 10.01 1148 440137 116973 62930764
Melaena 57.52 10.01 385 440900 29980 63017757
Altered state of consciousness 56.58 10.01 334 440951 24896 63022841
Eating disorder 56.50 10.01 272 441013 18744 63028993
Renal artery stenosis 56.39 10.01 68 441217 1841 63045896
Weight increased 55.71 10.01 1383 439902 259409 62788328
Blood potassium decreased 55.62 10.01 490 440795 41536 63006201
Hepatotoxicity 54.80 10.01 109 441176 36932 63010805
Glomerular filtration rate decreased 54.35 10.01 211 441074 13230 63034507
Breast cancer stage III 53.85 10.01 5 441280 10381 63037356
Drug resistance 53.80 10.01 48 441237 22885 63024852
Malaise 53.72 10.01 3464 437821 412490 62635247
Carotid artery stenosis 53.56 10.01 114 441171 5056 63042681
Linear IgA disease 53.55 10.01 58 441227 1393 63046344
Urticaria 53.15 10.01 821 440464 164981 62882756
Adjustment disorder with depressed mood 52.67 10.01 5 441280 10199 63037538
Aphasia 52.41 10.01 401 440884 32599 63015138
Foot deformity 52.40 10.01 70 441215 27783 63019954
Injection site swelling 52.39 10.01 163 441122 47409 63000328
Febrile neutropenia 52.32 10.01 548 440737 117901 62929836
Gastrointestinal haemorrhage 51.61 10.01 822 440463 80354 62967383
Renal disorder 50.88 10.01 398 440887 32576 63015161
Adverse event 50.76 10.01 269 441016 67290 62980447
Anti-neutrophil cytoplasmic antibody positive vasculitis 50.46 10.01 80 441205 2819 63044918
Pemphigoid 50.30 10.01 138 441147 7206 63040531
Affect lability 50.03 10.01 181 441104 10970 63036767
Respiratory failure 50.01 10.01 990 440295 100868 62946869
Tenosynovitis 49.48 10.01 17 441268 13778 63033959
Loss of personal independence in daily activities 49.38 10.01 435 440850 96855 62950882
Fatigue 48.75 10.01 5418 435867 882610 62165127
Vasodilatation 48.63 10.01 71 441214 2324 63045413
Lip swelling 48.52 10.01 376 440909 30687 63017050
Joint range of motion decreased 48.34 10.01 95 441190 32333 63015404
Dysphagia 47.60 10.01 873 440412 87712 62960025
Haemorrhage subcutaneous 47.42 10.01 79 441206 2904 63044833
Inappropriate antidiuretic hormone secretion 47.27 10.01 223 441062 15239 63032498
Product monitoring error 47.27 10.01 100 441185 4416 63043321
Swelling face 46.67 10.01 659 440626 62816 62984921
Hemiparesis 46.41 10.01 299 440986 22983 63024754
Infective pulmonary exacerbation of cystic fibrosis 46.37 10.01 4 441281 8813 63038924
Motor dysfunction 46.04 10.01 172 441113 10589 63037148
Injection site pruritus 45.95 10.01 160 441125 44956 63002781
Chest pain 45.55 10.01 1885 439400 214074 62833663
Dislocation of vertebra 45.19 10.01 4 441281 8631 63039106
Aortic dissection 44.17 10.01 62 441223 1956 63045781
Blood creatine phosphokinase increased 44.07 10.01 362 440923 30068 63017669
Sensory loss 43.27 10.01 163 441122 10075 63037662
Urine output decreased 42.37 10.01 174 441111 11196 63036541
Myelosuppression 42.17 10.01 62 441223 23641 63024096
BRASH syndrome 42.08 10.01 31 441254 438 63047299
Ear infection 42.03 10.01 131 441154 38082 63009655
X-ray abnormal 41.79 10.01 4 441281 8106 63039631
Supraventricular extrasystoles 41.68 10.01 96 441189 4493 63043244
Arrhythmia 41.20 10.01 426 440859 37714 63010023
Hypocalcaemia 41.06 10.01 368 440917 31345 63016392
Lacunar infarction 40.75 10.01 78 441207 3202 63044535
Pulmonary renal syndrome 40.72 10.01 30 441255 424 63047313
Hypervolaemia 40.61 10.01 337 440948 28076 63019661
Inflammation 39.94 10.01 372 440913 81901 62965836
Gangrene 39.91 10.01 113 441172 6010 63041727
Diarrhoea 39.85 10.01 5611 435674 709755 62337982
Injection site bruising 39.80 10.01 153 441132 41757 63005980
Gingival swelling 39.66 10.01 92 441193 4326 63043411
Electrocardiogram abnormal 39.51 10.01 147 441138 9032 63038705
Cough 39.21 10.01 2446 438839 290297 62757440
Body temperature increased 39.17 10.01 130 441155 37062 63010675
Injection site warmth 39.14 10.01 29 441256 15166 63032571
Atrioventricular block second degree 39.05 10.01 85 441200 3829 63043908
Premature labour 39.03 10.01 19 441266 12485 63035252
Glomerulonephritis rapidly progressive 38.89 10.01 41 441244 954 63046783
Gingival bleeding 38.82 10.01 182 441103 12405 63035332
Maternal exposure before pregnancy 38.52 10.01 4 441281 7599 63040138
Bundle branch block right 38.38 10.01 98 441187 4900 63042837
Nocturia 38.11 10.01 134 441151 8007 63039730
Suicide attempt 38.02 10.01 615 440670 60303 62987434
Peripheral venous disease 38.01 10.01 31 441254 15446 63032291
Drug dependence 38.00 10.01 70 441215 24413 63023324
Lip dry 37.98 10.01 31 441254 15439 63032298
Autoimmune disorder 37.90 10.01 38 441247 17139 63030598
Hyperuricaemia 37.87 10.01 102 441183 5268 63042469
Macular degeneration 37.56 10.01 70 441215 24306 63023431
Ear pain 37.52 10.01 127 441158 35991 63011746
Ischaemic stroke 37.27 10.01 233 441052 17724 63030013
Caesarean section 37.21 10.01 38 441247 16994 63030743
Plasma cell myeloma 36.89 10.01 397 440888 35508 63012229
Device dislocation 36.87 10.01 77 441208 25628 63022109
Disability 36.71 10.01 44 441241 18303 63029434
Allergic reaction to excipient 36.54 10.01 26 441259 347 63047390
Blood potassium increased 36.41 10.01 235 441050 18074 63029663
Haematemesis 36.40 10.01 347 440938 30065 63017672
Dyspnoea exertional 36.23 10.01 605 440680 59697 62988040
Hyperdynamic left ventricle 36.07 10.01 20 441265 166 63047571
Nodal rhythm 35.87 10.01 52 441233 1691 63046046
Hyperlipidaemia 35.79 10.01 246 441039 19325 63028412
Nephrosclerosis 35.23 10.01 40 441245 1014 63046723
Tubulointerstitial nephritis 35.12 10.01 248 441037 19655 63028082
Drug tolerance decreased 34.86 10.01 42 441243 17431 63030306
Product substitution issue 34.74 10.01 210 441075 15786 63031951
Breast cancer stage II 34.54 10.01 9 441276 8727 63039010
Myalgia 34.39 10.01 1294 439991 145235 62902502
Angina unstable 34.27 10.01 118 441167 6977 63040760
Pollakiuria 34.05 10.01 320 440965 27617 63020120
Neutropenia 33.92 10.01 941 440344 174064 62873673
Disorientation 33.73 10.01 421 440864 39031 63008706
Cardiac arrest 33.63 10.01 862 440423 91683 62956054
Hyperaldosteronism 33.38 10.01 21 441264 225 63047512
Blood pressure abnormal 33.31 10.01 200 441085 14998 63032739
Immunodeficiency 33.16 10.01 56 441229 20198 63027539
Vertigo 33.15 10.01 593 440692 59294 62988443
Feeling abnormal 33.06 10.01 1303 439982 147089 62900648
Multiple sclerosis relapse 32.65 10.01 200 441085 48278 62999459
Therapeutic response decreased 32.59 10.01 272 441013 61253 62986484
Arteriosclerosis 32.11 10.01 147 441138 9919 63037818
Retinitis 32.08 10.01 3 441282 6193 63041544
Unintended pregnancy 31.97 10.01 3 441282 6176 63041561
Muscle spasms 31.78 10.01 1358 439927 154792 62892945
Premature delivery 31.78 10.01 106 441179 30175 63017562
Intestinal malrotation 31.61 10.01 24 441261 356 63047381
Breast cancer stage I 31.59 10.01 5 441280 6884 63040853
Premature baby 31.55 10.01 60 441225 20675 63027062
Myocardial ischaemia 31.30 10.01 174 441111 12685 63035052
Tongue oedema 31.24 10.01 86 441199 4500 63043237
Fear of injection 31.10 10.01 6 441279 7158 63040579
Mitral valve incompetence 31.06 10.01 238 441047 19356 63028381
Ischaemia 31.04 10.01 88 441197 4684 63043053
Foetal death 30.90 10.01 19 441266 10961 63036776
Bladder irritation 30.82 10.01 20 441265 227 63047510
Drug withdrawal syndrome 30.78 10.01 92 441193 27102 63020635
Coordination abnormal 30.67 10.01 182 441103 13591 63034146
Maternal exposure timing unspecified 30.63 10.01 6 441279 7081 63040656
Night sweats 30.52 10.01 206 441079 48608 62999129
Therapy non-responder 30.40 10.01 359 440926 75542 62972195
Rheumatoid nodule 30.39 10.01 45 441240 17110 63030627
Enthesopathy 30.24 10.01 11 441274 8603 63039134
Wound infection 29.98 10.01 65 441220 21345 63026392
Sleep disorder 29.96 10.01 393 440892 81173 62966564
Joint destruction 29.92 10.01 4 441281 6248 63041489
Abortion induced 29.85 10.01 17 441268 10225 63037512
Subdural haematoma 29.79 10.01 186 441099 14142 63033595
Wrong technique in product usage process 29.77 10.01 283 441002 62057 62985680
Pulse abnormal 29.10 10.01 56 441229 2308 63045429
Injection site urticaria 28.96 10.01 33 441252 14040 63033697
Haemoglobin decreased 28.88 10.01 1262 440023 144223 62903514
Fibromuscular dysplasia 28.75 10.01 19 441266 223 63047514
Pleural effusion 28.73 10.01 850 440435 92360 62955377
Gastrointestinal toxicity 28.71 10.01 9 441276 7732 63040005
Hypothermia 28.68 10.01 177 441108 13404 63034333
Stillbirth 28.58 10.01 6 441279 6744 63040993
Gastric ulcer haemorrhage 28.57 10.01 87 441198 4821 63042916
Osteoarthritis 28.57 10.01 478 440807 94865 62952872
Haemodynamic instability 28.43 10.01 133 441152 9057 63038680
Haematochezia 28.17 10.01 526 440759 53018 62994719
C-reactive protein increased 27.99 10.01 476 440809 94231 62953506
Urinary retention 27.93 10.01 328 440957 29973 63017764
Product label on wrong product 27.83 10.01 7 441278 0 63047737
Neovascularisation 27.82 10.01 37 441248 1108 63046629
Heart rate decreased 27.70 10.01 458 440827 45102 63002635
Myocardial depression 27.63 10.01 25 441260 479 63047258
Loose tooth 27.58 10.01 68 441217 3326 63044411
Cerebral ischaemia 27.51 10.01 106 441179 6622 63041115
Adverse drug reaction 27.50 10.01 389 440896 79325 62968412
Mental status changes 27.47 10.01 407 440878 39192 63008545
Device difficult to use 27.44 10.01 29 441256 12767 63034970
Listless 27.28 10.01 61 441224 2799 63044938
Faeces discoloured 27.24 10.01 221 441064 18288 63029449
Ageusia 27.18 10.01 176 441109 13552 63034185
Protein urine present 27.17 10.01 99 441186 6021 63041716
Ovarian cyst 27.12 10.01 43 441242 15902 63031835
Dysgeusia 27.10 10.01 466 440819 46244 63001493
Glycosylated haemoglobin increased 27.08 10.01 163 441122 12235 63035502
Red blood cell sedimentation rate increased 26.81 10.01 187 441098 43795 63003942
Blood aldosterone increased 26.72 10.01 17 441268 186 63047551
Acute coronary syndrome 26.67 10.01 140 441145 9986 63037751
Breast cancer female 26.62 10.01 33 441252 13526 63034211
Therapy partial responder 26.61 10.01 21 441264 10637 63037100
Parkinsonism 26.58 10.01 143 441142 10296 63037441
Multiple drug therapy 26.47 10.01 70 441215 3576 63044161
Labile hypertension 26.44 10.01 24 441261 462 63047275
Purpura 26.36 10.01 152 441133 11233 63036504
Rib deformity 26.30 10.01 19 441266 260 63047477
Sinus arrest 26.27 10.01 48 441237 1901 63045836
Gravitational oedema 26.13 10.01 37 441248 1177 63046560
Hypoxia 26.02 10.01 571 440714 59221 62988516
Uterine perforation 26.00 10.01 8 441277 6955 63040782
Gingival pain 25.89 10.01 119 441166 8043 63039694
Periodontitis 25.61 10.01 65 441220 3238 63044499
Deformity 25.60 10.01 26 441259 11658 63036079
Blood glucose decreased 25.54 10.01 240 441045 20712 63027025
Hallucination, visual 25.53 10.01 225 441060 19073 63028664
Cardiac failure chronic 25.42 10.01 78 441207 4340 63043397
Device adhesion issue 25.30 10.01 3 441282 5138 63042599
Contusion 25.30 10.01 822 440463 149222 62898515
Haemodialysis 25.17 10.01 126 441159 8821 63038916
Peripheral arterial occlusive disease 24.95 10.01 75 441210 4126 63043611
Body tinea 24.87 10.01 46 441239 1839 63045898
Unintentional medical device removal 24.76 10.01 6 441279 6109 63041628
Hepatocellular carcinoma 24.63 10.01 50 441235 2144 63045593
Arterial occlusive disease 24.47 10.01 94 441191 5864 63041873
Scleral discolouration 24.34 10.01 22 441263 421 63047316
Dementia 24.28 10.01 218 441067 18576 63029161
Aortic aneurysm 24.14 10.01 70 441215 3774 63043963
Haematotoxicity 24.01 10.01 18 441267 9358 63038379
Conjoined twins 23.99 10.01 18 441267 262 63047475
Nephrogenic systemic fibrosis 23.98 10.01 78 441207 4478 63043259
Skin candida 23.90 10.01 42 441243 1613 63046124
Generalised oedema 23.89 10.01 190 441095 15628 63032109
Cerebral haemorrhage 23.79 10.01 322 440963 30407 63017330
Joint effusion 23.72 10.01 52 441233 17008 63030729
C-reactive protein 23.66 10.01 3 441282 4879 63042858
Hypoglycaemic coma 23.53 10.01 54 441231 2521 63045216
Acute motor-sensory axonal neuropathy 23.48 10.01 18 441267 271 63047466
Upper respiratory tract infection 23.40 10.01 415 440870 81632 62966105
Claustrophobia 23.37 10.01 32 441253 986 63046751
Heavy menstrual bleeding 23.23 10.01 56 441229 17717 63030020
Lymphocyte stimulation test positive 23.22 10.01 23 441262 496 63047241
Obesity 23.20 10.01 118 441167 29834 63017903
Metastases to bone 23.15 10.01 72 441213 20947 63026790
Upper gastrointestinal haemorrhage 23.01 10.01 216 441069 18636 63029101
Anaphylactic reaction 23.00 10.01 322 440963 65778 62981959
Temperature regulation disorder 22.98 10.01 7 441278 6125 63041612
Skin exfoliation 22.87 10.01 424 440861 42678 63005059
Carotid arteriosclerosis 22.77 10.01 33 441252 1073 63046664
Atrioventricular dissociation 22.71 10.01 16 441269 210 63047527
Diabetic nephropathy 22.44 10.01 38 441247 1416 63046321
Vasculitis 22.40 10.01 209 441076 18000 63029737
Hypophagia 22.36 10.01 323 440962 30936 63016801
Coeliac disease 22.25 10.01 34 441251 12763 63034974
Bone erosion 22.24 10.01 57 441228 17660 63030077
Skin haemorrhage 22.23 10.01 133 441152 9961 63037776
Oedema 22.15 10.01 859 440426 96763 62950974
Vision blurred 22.09 10.01 814 440471 91110 62956627
Inhibitory drug interaction 22.02 10.01 56 441229 2793 63044944
Schizophrenia 21.97 10.01 22 441263 9930 63037807
Lethargy 21.93 10.01 527 440758 55480 62992257
Presyncope 21.86 10.01 292 440993 27493 63020244
Colitis ulcerative 21.83 10.01 100 441185 25991 63021746
Sinus congestion 21.79 10.01 207 441078 17916 63029821
Prescription drug used without a prescription 21.76 10.01 50 441235 2336 63045401
Medication error 21.71 10.01 496 440789 51788 62995949
Diabetes mellitus 21.51 10.01 524 440761 55286 62992451
Acute respiratory distress syndrome 21.36 10.01 254 441031 23280 63024457
Septic shock 21.30 10.01 330 440955 66299 62981438
Head discomfort 21.29 10.01 163 441122 13252 63034485
Hyperkaliuria 21.28 10.01 10 441275 56 63047681
Intestinal villi atrophy 21.26 10.01 16 441269 234 63047503
Gingivitis 21.15 10.01 115 441170 8314 63039423
Reduced facial expression 21.12 10.01 44 441241 1922 63045815
Pathogen resistance 21.09 10.01 9 441276 6389 63041348
Harlequin syndrome 20.99 10.01 9 441276 39 63047698
Finger deformity 20.98 10.01 14 441271 7731 63040006
Joint injury 20.97 10.01 120 441165 29452 63018285
Hypertensive encephalopathy 20.96 10.01 24 441261 614 63047123
Gallbladder adenocarcinoma 20.92 10.01 12 441273 107 63047630
Hypoperfusion 20.89 10.01 37 441248 1430 63046307
Joint stiffness 20.88 10.01 188 441097 41681 63006056
Pericardial effusion 20.87 10.01 309 440976 29749 63017988
Hypertensive heart disease 20.86 10.01 50 441235 2402 63045335
Ventricular extrasystoles 20.84 10.01 146 441139 11541 63036196
Autoimmune enteropathy 20.82 10.01 6 441279 4 63047733
Lymphocele 20.78 10.01 27 441258 790 63046947
Acute hepatic failure 20.74 10.01 62 441223 18265 63029472
Acute respiratory failure 20.72 10.01 346 440939 34139 63013598
Lichen nitidus 20.71 10.01 11 441274 83 63047654
Psychotic disorder 20.66 10.01 100 441185 25612 63022125
Gingival atrophy 20.64 10.01 8 441277 25 63047712
Hypernatraemia 20.59 10.01 106 441179 7503 63040234
Drug hypersensitivity 20.57 10.01 1869 439416 308818 62738919
Cholecystitis chronic 20.57 10.01 25 441260 10336 63037401
Leukopenia 20.46 10.01 396 440889 76894 62970843
Urine albumin/creatinine ratio increased 20.32 10.01 17 441268 292 63047445
Retinal ischaemia 20.19 10.01 18 441267 338 63047399
Haemorrhage intracranial 20.17 10.01 161 441124 13258 63034479
Bradyarrhythmia 20.05 10.01 45 441240 2070 63045667
Cryopyrin associated periodic syndrome 20.02 10.01 18 441267 342 63047395
Hypoglossal nerve paralysis 19.92 10.01 7 441278 15 63047722
Renal transplant 19.90 10.01 35 441250 1345 63046392
Blood uric acid increased 19.89 10.01 82 441203 5285 63042452
Femoral neck fracture 19.87 10.01 114 441171 8409 63039328
Sinus rhythm 19.79 10.01 27 441258 829 63046908
Lecithin-cholesterol acyltransferase deficiency 19.74 10.01 6 441279 6 63047731
Electrolyte imbalance 19.71 10.01 220 441065 19856 63027881
Skin discolouration 19.69 10.01 371 440914 37457 63010280
Injection site rash 19.63 10.01 66 441219 18743 63028994
Cardiomegaly 19.62 10.01 198 441087 17416 63030321
Product tampering 19.59 10.01 19 441266 399 63047338
Oral discharge 19.57 10.01 13 441272 154 63047583
Cytomegalovirus infection 19.57 10.01 77 441208 20875 63026862
Pseudolymphoma 19.56 10.01 23 441262 606 63047131
Blood sodium decreased 19.55 10.01 256 441029 23996 63023741
Blood loss anaemia 19.44 10.01 118 441167 8883 63038854
Nephrogenic anaemia 19.38 10.01 45 441240 2117 63045620
Restlessness 19.37 10.01 300 440985 29153 63018584
Skin tightness 19.31 10.01 70 441215 4246 63043491
Multiple-drug resistance 19.20 10.01 6 441279 5164 63042573
Benign neoplasm of adrenal gland 19.15 10.01 8 441277 32 63047705
Product dispensing error 19.12 10.01 130 441155 10175 63037562
Forced vital capacity decreased 19.09 10.01 30 441255 1049 63046688
Galactorrhoea 19.09 10.01 3 441282 4152 63043585
Venoocclusive liver disease 19.08 10.01 5 441280 4830 63042907
Nephrotic syndrome 18.97 10.01 83 441202 5493 63042244
Kidney transplant rejection 18.89 10.01 69 441216 4202 63043535
Jaundice 18.88 10.01 297 440988 28954 63018783
Product storage error 18.87 10.01 48 441237 14908 63032829
Rectourethral fistula 18.78 10.01 8 441277 34 63047703
Ballismus 18.73 10.01 12 441273 133 63047604
Blood lactic acid increased 18.68 10.01 98 441187 6988 63040749
Dermatitis bullous 18.67 10.01 112 441173 8396 63039341
Tachypnoea 18.56 10.01 193 441092 17109 63030628
Congenital bladder anomaly 18.43 10.01 13 441272 171 63047566
Interstitial lung disease 18.39 10.01 562 440723 61346 62986391
Gout 18.22 10.01 156 441129 13115 63034622
Organ failure 18.10 10.01 50 441235 2621 63045116
Glucose tolerance impaired 18.06 10.01 92 441193 6485 63041252
Sudden hearing loss 18.06 10.01 32 441253 1237 63046500
Malpositioned teeth 18.03 10.01 7 441278 22 63047715
Pulmonary hypertension 17.93 10.01 360 440925 36763 63010974
Urachal abnormality 17.93 10.01 13 441272 179 63047558
Fryns syndrome 17.87 10.01 9 441276 60 63047677
Dialysis 17.86 10.01 129 441156 10298 63037439
Cardiorenal syndrome 17.86 10.01 26 441259 849 63046888
Sinus node dysfunction 17.70 10.01 72 441213 4613 63043124
Adenoma benign 17.65 10.01 26 441259 858 63046879
Apathy 17.56 10.01 113 441172 8681 63039056
Diffuse large B-cell lymphoma refractory 17.48 10.01 31 441254 1199 63046538
Intestinal ischaemia 17.48 10.01 100 441185 7368 63040369
Full blood count decreased 17.47 10.01 266 441019 25758 63021979
Gamma-glutamyltransferase increased 17.45 10.01 333 440952 33698 63014039
Aortic stenosis 17.29 10.01 75 441210 4945 63042792
Haematoma 17.27 10.01 339 440946 34481 63013256
Procedural pain 17.26 10.01 84 441201 21485 63026252
Rectal ulcer haemorrhage 17.22 10.01 13 441272 191 63047546
Persistent cloaca 17.17 10.01 13 441272 192 63047545
Putamen haemorrhage 17.17 10.01 13 441272 192 63047545
Ventricular failure 17.15 10.01 17 441268 367 63047370
Conduction disorder 17.14 10.01 34 441251 1433 63046304
Sneezing 17.14 10.01 198 441087 18020 63029717
Tendonitis 17.12 10.01 74 441211 19541 63028196
Ankylosing spondylitis 17.11 10.01 29 441256 10445 63037292
Substance abuse 17.11 10.01 6 441279 4801 63042936
Labelled drug-drug interaction medication error 17.10 10.01 155 441130 13244 63034493
Cardiac hypertrophy 17.05 10.01 28 441257 1017 63046720
Osteoporosis 17.00 10.01 288 440997 57050 62990687
Product solubility abnormal 16.97 10.01 25 441260 825 63046912
Drug tolerance 16.96 10.01 14 441271 6935 63040802
Cardiac disorder 16.93 10.01 468 440817 50348 62997389
Humerus fracture 16.86 10.01 113 441172 8803 63038934
Vitello-intestinal duct remnant 16.85 10.01 8 441277 46 63047691
Irritability 16.84 10.01 140 441145 31554 63016183
Skin induration 16.80 10.01 55 441230 3168 63044569
Haemorrhagic diathesis 16.79 10.01 68 441217 4347 63043390
Vitamin B1 decreased 16.78 10.01 13 441272 199 63047538
Post transplant lymphoproliferative disorder 16.71 10.01 7 441278 5024 63042713
Insulin-like growth factor decreased 16.71 10.01 17 441268 379 63047358
Kidney fibrosis 16.70 10.01 39 441246 1842 63045895
Acute myeloid leukaemia 16.67 10.01 62 441223 17085 63030652
Renal cell carcinoma 16.58 10.01 56 441229 3279 63044458
Adulterated product 16.56 10.01 14 441271 244 63047493
Haemorrhage subepidermal 16.45 10.01 5 441280 5 63047732
Cerebrovascular disorder 16.44 10.01 49 441236 2683 63045054
Congenital acrochordon 16.44 10.01 8 441277 49 63047688
Hypomania 16.41 10.01 12 441273 6318 63041419
Confusional state 16.39 10.01 1880 439405 234500 62813237
Complication of device insertion 16.38 10.01 17 441268 7547 63040190
Female genital tract fistula 16.36 10.01 17 441268 7542 63040195
Gingival disorder 16.32 10.01 58 441227 3484 63044253
Urinary incontinence 16.32 10.01 313 440972 31701 63016036
Muscular weakness 16.28 10.01 1022 440263 121331 62926406
Transcription medication error 16.25 10.01 13 441272 209 63047528
Nodule 16.19 10.01 83 441202 20943 63026794
Neurotoxicity 16.15 10.01 62 441223 16928 63030809
Suspected product quality issue 16.10 10.01 13 441272 212 63047525
Infected dermal cyst 16.08 10.01 18 441267 449 63047288
Sickle cell anaemia with crisis 16.06 10.01 11 441274 5992 63041745
Abnormal loss of weight 15.96 10.01 81 441204 5701 63042036
Hyperparathyroidism secondary 15.95 10.01 33 441252 1434 63046303
Peritoneal effluent leukocyte count increased 15.90 10.01 4 441281 0 63047737
Tremor 15.88 10.01 1095 440190 131144 62916593
Exercise tolerance decreased 15.88 10.01 78 441207 5419 63042318
Iliac artery occlusion 15.86 10.01 12 441273 177 63047560
Neurosensory hypoacusis 15.84 10.01 13 441272 217 63047520
Hypergastrinaemia 15.83 10.01 10 441275 108 63047629
Dyslalia 15.77 10.01 18 441267 459 63047278
Lupus-like syndrome 15.73 10.01 54 441231 15241 63032496
Vulvovaginal pruritus 15.72 10.01 54 441231 3189 63044548
Essential hypertension 15.68 10.01 73 441212 4960 63042777
Blood cholinesterase increased 15.66 10.01 6 441279 18 63047719
Incorrect route of product administration 15.63 10.01 119 441166 27333 63020404
Nephropathy 15.57 10.01 86 441199 6255 63041482
Bacteriuria 15.56 10.01 27 441258 1026 63046711
Saliva discolouration 15.53 10.01 7 441278 35 63047702
Dystonia 15.46 10.01 47 441238 13772 63033965
Hyperprolactinaemia 15.45 10.01 4 441281 3896 63043841
Ischaemic cardiomyopathy 15.45 10.01 45 441240 2432 63045305
Retroperitoneal haematoma 15.45 10.01 50 441235 2863 63044874
Dermatitis exfoliative 15.44 10.01 77 441208 5382 63042355
Burn oesophageal 15.42 10.01 12 441273 185 63047552
Fluid intake reduced 15.41 10.01 58 441227 3583 63044154
Apical granuloma 15.37 10.01 7 441278 36 63047701
Hypertensive angiopathy 15.35 10.01 9 441276 84 63047653
Blood cholinesterase decreased 15.23 10.01 10 441275 116 63047621
CD30 expression 15.22 10.01 7 441278 37 63047700
Albuminuria 15.22 10.01 13 441272 230 63047507
Synovial cyst 15.17 10.01 31 441254 10402 63037335
Nasal oedema 15.12 10.01 33 441252 1489 63046248
Cytokine release syndrome 15.09 10.01 50 441235 14264 63033473
Sciatica 15.06 10.01 159 441126 34165 63013572
Generalised tonic-clonic seizure 15.04 10.01 129 441156 28887 63018850
Crush syndrome 15.01 10.01 10 441275 119 63047618
Norepinephrine increased 14.99 10.01 8 441277 61 63047676
Prescribed underdose 14.94 10.01 133 441152 29556 63018181
Drug use disorder 14.92 10.01 8 441277 4976 63042761
Chronic pigmented purpura 14.90 10.01 11 441274 156 63047581
Prerenal failure 14.88 10.01 35 441250 1661 63046076
Metabolic alkalosis 14.86 10.01 51 441234 3010 63044727
Sinoatrial block 14.77 10.01 24 441261 864 63046873
Cerebral atrophy 14.71 10.01 72 441213 4994 63042743
Dry skin 14.71 10.01 508 440777 56379 62991358
Subarachnoid haemorrhage 14.70 10.01 158 441127 14125 63033612
Ventricular septal defect 14.69 10.01 6 441279 4372 63043365
Epistaxis 14.68 10.01 632 440653 72093 62975644
Glomerulonephritis acute 14.66 10.01 9 441276 92 63047645
Electrocardiogram U wave present 14.66 10.01 9 441276 92 63047645
Normal newborn 14.66 10.01 22 441263 8319 63039418
Immunosuppressant drug level increased 14.62 10.01 57 441228 3581 63044156
Myoglobin blood increased 14.58 10.01 31 441254 1374 63046363
Hallucination, gustatory 14.57 10.01 8 441277 65 63047672
Diverticulum intestinal haemorrhagic 14.56 10.01 33 441252 1528 63046209
Aplastic anaemia 14.48 10.01 115 441170 9454 63038283
Ocular icterus 14.46 10.01 57 441228 3599 63044138
Lung disorder 14.42 10.01 326 440959 61935 62985802
Congenital nail disorder 14.42 10.01 9 441276 95 63047642
Disturbance in social behaviour 14.19 10.01 5 441280 3988 63043749
Platelet aggregation decreased 14.18 10.01 6 441279 25 63047712
Lymphocyte count decreased 14.17 10.01 138 441147 30119 63017618
Sodium retention 14.14 10.01 10 441275 132 63047605
Oropharyngeal swelling 14.12 10.01 24 441261 897 63046840
Oxalosis 14.11 10.01 7 441278 45 63047692
Biopsy kidney 14.08 10.01 10 441275 133 63047604
Drug ineffective for unapproved indication 14.07 10.01 160 441125 33903 63013834
Azotaemia 14.04 10.01 65 441220 4406 63043331
Anorexia nervosa 14.04 10.01 13 441272 257 63047480
Flatulence 14.03 10.01 328 440957 34374 63013363
Platelet count decreased 14.02 10.01 962 440323 115160 62932577
Cytomegalovirus infection reactivation 14.01 10.01 5 441280 3958 63043779
Acute pulmonary oedema 14.01 10.01 101 441184 8057 63039680
Pancreatic toxicity 13.99 10.01 6 441279 26 63047711
Bone marrow failure 13.97 10.01 133 441152 29157 63018580
Shock haemorrhagic 13.94 10.01 117 441168 9778 63037959
Peritonitis bacterial 13.93 10.01 69 441216 4810 63042927
Sensorimotor disorder 13.85 10.01 17 441268 469 63047268
Thirst 13.84 10.01 154 441131 13887 63033850
Pulmonary toxicity 13.83 10.01 28 441257 9427 63038310
Vulvovaginal burning sensation 13.82 10.01 39 441246 2070 63045667
Cystic fibrosis 13.81 10.01 3 441282 3293 63044444
Cell marker increased 13.75 10.01 13 441272 264 63047473
Colitis ischaemic 13.73 10.01 124 441161 10584 63037153
Renal function test abnormal 13.69 10.01 56 441229 3597 63044140
Device deployment issue 13.67 10.01 5 441280 3897 63043840
Polycystic ovaries 13.64 10.01 7 441278 4464 63043273
Stomatitis haemorrhagic 13.64 10.01 6 441279 28 63047709
Capillary disorder 13.61 10.01 8 441277 75 63047662
Status epilepticus 13.58 10.01 57 441228 15176 63032561
Sinus arrhythmia 13.58 10.01 31 441254 1442 63046295
Premature rupture of membranes 13.56 10.01 9 441276 4984 63042753
Concomitant disease progression 13.54 10.01 39 441246 2095 63045642
Metastatic renal cell carcinoma 13.53 10.01 22 441263 792 63046945
Maternal drugs affecting foetus 13.51 10.01 10 441275 5232 63042505
Orthopnoea 13.47 10.01 82 441203 6179 63041558
Dysphoria 13.42 10.01 9 441276 4957 63042780
Skin weeping 13.41 10.01 21 441264 732 63047005
Shock symptom 13.38 10.01 7 441278 51 63047686
Soft tissue disorder 13.38 10.01 7 441278 4415 63043322
Peritonitis 13.38 10.01 180 441105 16974 63030763
Pulmonary arterial hypertension 13.37 10.01 226 441059 22351 63025386
End stage renal disease 13.37 10.01 86 441199 6607 63041130
Nail disorder 13.36 10.01 46 441239 12969 63034768
Gastrointestinal stromal tumour 13.32 10.01 26 441259 1083 63046654
Hypoacusis 13.31 10.01 239 441046 23912 63023825
Duodenal ulcer 13.31 10.01 96 441189 7660 63040077
Atrial pressure increased 13.30 10.01 5 441280 14 63047723
Chromaturia 13.28 10.01 176 441109 16541 63031196
Cardiovascular disorder 13.26 10.01 133 441152 11679 63036058
Accidental exposure to product 13.26 10.01 124 441161 27281 63020456
Genital haemorrhage 13.22 10.01 19 441266 7313 63040424
Venous aneurysm 13.16 10.01 4 441281 4 63047733
Therapeutic drug monitoring analysis not performed 13.08 10.01 29 441256 1323 63046414
Duodenal ulcer repair 13.05 10.01 7 441278 54 63047683
Renal aneurysm 13.05 10.01 5 441280 15 63047722
Psychogenic visual disorder 13.05 10.01 5 441280 15 63047722
Orbital swelling 13.05 10.01 7 441278 54 63047683
Sexual dysfunction 13.04 10.01 7 441278 4352 63043385
Gestational diabetes 13.03 10.01 24 441261 8372 63039365
Chondroma 13.00 10.01 6 441279 32 63047705
Renal tubular necrosis 12.98 10.01 133 441152 11745 63035992
Staphylococcal infection 12.96 10.01 205 441080 41051 63006686
Metastases to fallopian tube 12.95 10.01 7 441278 55 63047682
Hospice care 12.94 10.01 97 441188 7835 63039902
Eye oedema 12.94 10.01 31 441254 1489 63046248
Retinopathy hypertensive 12.93 10.01 12 441273 238 63047499
Device malfunction 12.91 10.01 72 441213 17785 63029952
Yellow skin 12.88 10.01 40 441245 2240 63045497
Microalbuminuria 12.88 10.01 15 441270 391 63047346
International normalised ratio increased 12.88 10.01 418 440867 46007 63001730
Malignant hypertension 12.86 10.01 27 441258 1186 63046551
Dermatosis 12.84 10.01 13 441272 288 63047449
Blood sodium increased 12.82 10.01 45 441240 2687 63045050
Pigmentation disorder 12.81 10.01 65 441220 4574 63043163
Bladder sphincter atony 12.80 10.01 10 441275 155 63047582
Small cell carcinoma 12.75 10.01 10 441275 156 63047581
Enterochromaffin cell hyperplasia 12.74 10.01 7 441278 57 63047680
Head injury 12.68 10.01 264 441021 27132 63020605
Device issue 12.65 10.01 105 441180 23676 63024061
Internal haemorrhage 12.65 10.01 70 441215 5095 63042642
Anti-erythropoietin antibody positive 12.64 10.01 15 441270 399 63047338
Chronic graft versus host disease 12.64 10.01 3 441282 3099 63044638
Mean arterial pressure decreased 12.64 10.01 10 441275 158 63047579
Osteopenia 12.61 10.01 83 441202 19702 63028035
Pulmonary alveolar haemorrhage 12.61 10.01 65 441220 4603 63043134
Myocardial oedema 12.59 10.01 11 441274 201 63047536
Head banging 12.59 10.01 15 441270 401 63047336
Ventricular internal diameter abnormal 12.57 10.01 6 441279 35 63047702
Mucosal inflammation 12.55 10.01 240 441045 46688 63001049
Heat illness 12.54 10.01 11 441274 202 63047535
Bifascicular block 12.53 10.01 9 441276 122 63047615
Dysphonia 12.52 10.01 426 440859 47188 63000549
Cerebellar haemorrhage 12.48 10.01 29 441256 1365 63046372
Femoral artery dissection 12.43 10.01 6 441279 36 63047701
Jaundice hepatocellular 12.43 10.01 6 441279 36 63047701
Palmar-plantar erythrodysaesthesia syndrome 12.42 10.01 227 441058 22788 63024949
Lower limb fracture 12.41 10.01 108 441177 24113 63023624
Urine protein/creatinine ratio increased 12.37 10.01 19 441266 651 63047086
Oesophageal food impaction 12.37 10.01 11 441274 206 63047531
Congenital diaphragmatic hernia 12.32 10.01 11 441274 207 63047530
Dry eye 12.32 10.01 204 441081 40557 63007180
Brain stem infarction 12.29 10.01 21 441264 788 63046949
Pernicious anaemia 12.29 10.01 19 441266 655 63047082
Rheumatoid factor negative 12.24 10.01 18 441267 593 63047144
Diastolic dysfunction 12.23 10.01 82 441203 6389 63041348
Blood alkaline phosphatase increased 12.21 10.01 388 440897 42579 63005158
Blood chloride decreased 12.19 10.01 73 441212 5469 63042268
Cerebrovascular arteriovenous malformation 12.17 10.01 8 441277 93 63047644
Zinc deficiency 12.15 10.01 7 441278 63 63047674
Dilatation ventricular 12.10 10.01 41 441244 2404 63045333
Cranial nerve disorder 12.07 10.01 17 441268 538 63047199
Cardiac failure acute 12.07 10.01 110 441175 9413 63038324
Chest X-ray abnormal 12.05 10.01 63 441222 4486 63043251
Hip fracture 12.05 10.01 279 441006 29195 63018542
Extrasystoles 12.02 10.01 69 441216 5091 63042646
Cataract 12.01 10.01 498 440787 56555 62991182
Cutaneous vasculitis 11.97 10.01 70 441215 5199 63042538
Leukaemic infiltration renal 11.97 10.01 5 441280 20 63047717
Retroperitoneal oedema 11.97 10.01 5 441280 20 63047717
Colon cancer 11.96 10.01 113 441172 9765 63037972
Adrenal gland cancer metastatic 11.93 10.01 3 441282 0 63047737
Mixed dementia 11.93 10.01 3 441282 0 63047737
Biliary hamartoma 11.93 10.01 3 441282 0 63047737
Tongue abscess 11.93 10.01 3 441282 0 63047737
Peripheral nerve paresis 11.93 10.01 3 441282 0 63047737
Hypovolaemia 11.90 10.01 120 441165 10553 63037184
Tonsillar inflammation 11.89 10.01 8 441277 97 63047640
Hepatorenal failure 11.87 10.01 19 441266 675 63047062
Vomiting 11.87 10.01 4196 437089 555421 62492316
Road traffic accident 11.85 10.01 181 441104 36451 63011286
Foot operation 11.83 10.01 20 441265 7211 63040526
Ultrasound uterus abnormal 11.79 10.01 7 441278 67 63047670
Congenital syphilitic osteochondritis 11.78 10.01 5 441280 21 63047716
Blood lactic acid 11.75 10.01 8 441277 99 63047638
Immune reconstitution inflammatory syndrome 11.74 10.01 15 441270 6069 63041668
Blood parathyroid hormone increased 11.72 10.01 47 441238 2991 63044746
Bronchiectasis 11.72 10.01 65 441220 16077 63031660
Electrocardiogram QT prolonged 11.71 10.01 516 440769 59014 62988723
Pseudoaldosteronism 11.70 10.01 7 441278 68 63047669
Therapeutic product effect increased 11.68 10.01 26 441259 1189 63046548
Visual acuity reduced 11.68 10.01 215 441070 21611 63026126
Vascular access site pain 11.68 10.01 8 441277 100 63047637
Carcinoid tumour 11.67 10.01 14 441271 377 63047360
Mouth haemorrhage 11.66 10.01 84 441201 6699 63041038
Traumatic haemorrhage 11.63 10.01 17 441268 557 63047180
Gastric cyst 11.61 10.01 8 441277 101 63047636
Peritoneal dialysis complication 11.61 10.01 26 441259 1194 63046543
Thalamus haemorrhage 11.57 10.01 19 441266 690 63047047
Adrenocortical carcinoma 11.55 10.01 6 441279 43 63047694
Withdrawal hypertension 11.55 10.01 9 441276 139 63047598
Hepatic cirrhosis 11.50 10.01 113 441172 24621 63023116
Glomerulonephritis 11.45 10.01 33 441252 1773 63045964
Renal injury 11.44 10.01 108 441177 9331 63038406
Gastric pH increased 11.44 10.01 6 441279 44 63047693
Tenderness 11.43 10.01 101 441184 22477 63025260
Porphyrins urine increased 11.43 10.01 5 441280 23 63047714
Acquired porphyria 11.43 10.01 5 441280 23 63047714
Faeces hard 11.42 10.01 37 441248 2120 63045617
Hyperparathyroidism primary 11.41 10.01 14 441271 386 63047351
Accelerated hypertension 11.41 10.01 15 441270 444 63047293
Faecal calprotectin increased 11.40 10.01 4 441281 3199 63044538
Lichen planus 11.39 10.01 39 441246 2299 63045438
Neurodegenerative disorder 11.37 10.01 13 441272 332 63047405
Exostosis 11.35 10.01 75 441210 17787 63029950
Injection site haemorrhage 11.34 10.01 111 441174 24203 63023534
Device use error 11.33 10.01 14 441271 5747 63041990
Pulmonary hypoplasia 11.32 10.01 12 441273 281 63047456
Systemic infection 11.30 10.01 63 441222 4597 63043140
Gastroenteritis 11.27 10.01 253 441032 26337 63021400
Cardiac valve sclerosis 11.26 10.01 5 441280 24 63047713
Hypereosinophilic syndrome 11.22 10.01 12 441273 284 63047453
Haemorrhagic infarction 11.19 10.01 12 441273 285 63047452
Uveitis 11.18 10.01 47 441238 12506 63035231
Aortic occlusion 11.17 10.01 8 441277 108 63047629
Intermenstrual bleeding 11.15 10.01 24 441261 7902 63039835
Hypoaesthesia 11.13 10.01 1013 440272 167380 62880357
Mydriasis 11.13 10.01 44 441241 11912 63035825
Coronary arterial stent insertion 11.10 10.01 44 441241 2785 63044952
Product administration error 11.09 10.01 218 441067 22179 63025558
Fibrosis 11.07 10.01 58 441227 4134 63043603
Toxic epidermal necrolysis 11.04 10.01 242 441043 25092 63022645
Blood lactic acid decreased 11.03 10.01 9 441276 149 63047588
Duodenal ulcer haemorrhage 11.03 10.01 40 441245 2427 63045310
Wrong drug 10.99 10.01 10 441275 193 63047544
Nightmare 10.95 10.01 191 441094 19003 63028734
IgA nephropathy 10.95 10.01 17 441268 588 63047149
Proctitis 10.94 10.01 13 441272 5428 63042309
Blood pressure diastolic decreased 10.90 10.01 220 441065 22486 63025251
Peripheral artery stenosis 10.89 10.01 17 441268 591 63047146
Abdominal distension 10.89 10.01 720 440565 85895 62961842
Renal neoplasm 10.86 10.01 26 441259 1248 63046489
Hyperplastic cholecystopathy 10.79 10.01 9 441276 154 63047583
Pharyngitis streptococcal 10.76 10.01 38 441247 10634 63037103
Oesophageal achalasia 10.74 10.01 15 441270 471 63047266
Neurofibrosarcoma 10.74 10.01 9 441276 155 63047582
Tinnitus 10.73 10.01 324 440961 35304 63012433
Erythema multiforme 10.70 10.01 113 441172 10056 63037681
Bronchial secretion retention 10.69 10.01 3 441282 2770 63044967
Pneumothorax traumatic 10.64 10.01 9 441276 157 63047580
Oesophageal carcinoma recurrent 10.64 10.01 5 441280 28 63047709
Diabetic retinopathy 10.63 10.01 38 441247 2289 63045448
Oesophageal atresia 10.62 10.01 16 441269 539 63047198
Periarticular disorder 10.61 10.01 6 441279 52 63047685
Base excess decreased 10.60 10.01 7 441278 82 63047655
Musculoskeletal disorder 10.60 10.01 92 441193 20552 63027185
Carcinoid tumour of the stomach 10.59 10.01 9 441276 158 63047579
Nasal polyps 10.54 10.01 16 441269 6023 63041714
Urate nephropathy 10.52 10.01 8 441277 119 63047618
Retinopathy proliferative 10.51 10.01 6 441279 53 63047684
Febrile bone marrow aplasia 10.45 10.01 22 441263 7303 63040434
Blood lactate dehydrogenase increased 10.45 10.01 222 441063 22894 63024843
Page kidney 10.44 10.01 4 441281 12 63047725
Osteocalcin decreased 10.42 10.01 6 441279 54 63047683
No adverse event 10.40 10.01 214 441071 41191 63006546
Porphyrins stool increased 10.36 10.01 5 441280 30 63047707
Congenital uterine anomaly 10.35 10.01 8 441277 122 63047615
Renal cyst infection 10.35 10.01 8 441277 122 63047615
Facial nerve disorder 10.32 10.01 16 441269 553 63047184
Unresponsive to stimuli 10.31 10.01 308 440977 33508 63014229
Gastric ulcer 10.28 10.01 229 441056 23808 63023929
Cerebrovascular insufficiency 10.25 10.01 7 441278 87 63047650
Secondary hypertension 10.23 10.01 9 441276 166 63047571
Varicella zoster virus infection 10.20 10.01 3 441282 2686 63045051
Anal fistula 10.20 10.01 6 441279 3545 63044192
Lymphadenopathy 10.19 10.01 197 441088 38261 63009476
Oculomucocutaneous syndrome 10.19 10.01 8 441277 125 63047612
Aspergillus infection 10.19 10.01 26 441259 8067 63039670
Urine flow decreased 10.16 10.01 11 441274 264 63047473
Normochromic normocytic anaemia 10.15 10.01 61 441224 4575 63043162
Obsessive-compulsive disorder 10.14 10.01 8 441277 4052 63043685
Optic nerve injury 10.13 10.01 16 441269 562 63047175
Blood sodium abnormal 10.10 10.01 18 441267 699 63047038
Face oedema 10.10 10.01 197 441088 20015 63027722
Thrombotic thrombocytopenic purpura 10.08 10.01 53 441232 3783 63043954

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 682.31 11.16 2352 348528 95816 34510235
Drug abuse 477.98 11.16 198 350682 98898 34507153
Off label use 421.75 11.16 2481 348399 417043 34189008
Gingival hypertrophy 409.26 11.16 245 350635 1576 34604475
Drug ineffective 396.72 11.16 2824 348056 453927 34152124
Shock 267.70 11.16 684 350196 23495 34582556
Blood pressure inadequately controlled 261.66 11.16 215 350665 2425 34603626
Hypotension 251.89 11.16 3360 347520 218289 34387762
Intentional overdose 231.27 11.16 960 349920 42714 34563337
Bradycardia 228.35 11.16 1416 349464 74002 34532049
Hypertensive crisis 209.46 11.16 341 350539 8410 34597641
Foetal exposure during pregnancy 190.34 11.16 72 350808 38029 34568022
Product use in unapproved indication 188.27 11.16 580 350300 116919 34489132
Distributive shock 186.14 11.16 130 350750 1124 34604927
Neutropenia 182.28 11.16 881 349999 155897 34450154
Oedema peripheral 178.77 11.16 1914 348966 117898 34488153
Acute kidney injury 171.13 11.16 4135 346745 300853 34305198
Febrile neutropenia 167.91 11.16 754 350126 136095 34469956
Treatment failure 158.50 11.16 141 350739 46556 34559495
Blood pressure increased 157.80 11.16 1462 349418 86640 34519411
Death 151.52 11.16 2952 347928 395097 34210954
Non-cardiogenic pulmonary oedema 140.98 11.16 86 350794 575 34605476
Angioedema 137.37 11.16 739 350141 36635 34569416
Cerebral infarction 118.51 11.16 568 350312 26887 34579164
Syncope 116.51 11.16 1417 349463 90034 34516017
Blood creatinine increased 111.34 11.16 1449 349431 93527 34512524
Angina pectoris 104.50 11.16 604 350276 30759 34575292
Hyperkalaemia 102.66 11.16 1107 349773 68282 34537769
Rhabdomyolysis 96.96 11.16 1079 349801 67084 34538967
Renal impairment 96.54 11.16 1407 349473 93106 34512945
Drug resistance 93.23 11.16 74 350806 25853 34580198
Hypokalaemia 92.84 11.16 943 349937 57271 34548780
Thrombocytopenia 88.80 11.16 1072 349808 155175 34450876
Swollen tongue 86.04 11.16 332 350548 14273 34591778
Drug dependence 85.98 11.16 70 350810 24147 34581904
Premature baby 85.64 11.16 45 350835 19588 34586463
Cerebrovascular accident 78.27 11.16 1241 349639 83570 34522481
Metabolic acidosis 78.20 11.16 725 350155 42955 34563096
Chronic kidney disease 77.33 11.16 691 350189 40519 34565532
Vasoplegia syndrome 76.78 11.16 94 350786 1762 34604289
Pancytopenia 74.97 11.16 603 350277 94554 34511497
Dizziness 71.80 11.16 2776 348104 215745 34390306
Suspected suicide 70.81 11.16 151 350729 4597 34601454
Sepsis 70.63 11.16 1211 349669 165350 34440701
Product use issue 69.47 11.16 362 350518 62854 34543197
Aggression 65.45 11.16 188 350692 38776 34567275
Blood pressure systolic increased 65.07 11.16 424 350456 22528 34583523
Pathogen resistance 64.96 11.16 9 350871 9473 34596578
Infusion related reaction 63.38 11.16 295 350585 52762 34553289
Immune reconstitution inflammatory syndrome 63.21 11.16 7 350873 8752 34597299
Leukopenia 62.49 11.16 372 350508 62484 34543567
Suicide attempt 62.04 11.16 633 350247 38483 34567568
Lip swelling 61.14 11.16 321 350559 15759 34590292
Disease progression 60.40 11.16 744 350136 107333 34498718
Lactic acidosis 59.66 11.16 572 350308 34200 34571851
Drug ineffective for unapproved indication 58.61 11.16 92 350788 23623 34582428
Proteinuria 56.95 11.16 351 350529 18291 34587760
Rheumatoid arthritis 56.82 11.16 195 350685 38043 34568008
Myelosuppression 55.38 11.16 67 350813 19198 34586853
Pyrexia 55.08 11.16 2757 348123 330256 34275795
Nocturia 53.66 11.16 224 350656 9986 34596065
C-reactive protein abnormal 53.63 11.16 11 350869 8699 34597352
Multiple organ dysfunction syndrome 53.27 11.16 501 350379 76065 34529986
Exposure during pregnancy 51.58 11.16 13 350867 8921 34597130
Hypertension 49.73 11.16 1754 349126 134689 34471362
Septic shock 49.56 11.16 471 350409 71363 34534688
Progressive multifocal leukoencephalopathy 49.51 11.16 18 350862 9746 34596305
Gastrointestinal tract mucosal pigmentation 48.76 11.16 40 350840 450 34605601
Synovitis 48.28 11.16 42 350838 14024 34592027
Cytokine release syndrome 48.21 11.16 98 350782 22779 34583272
Gingival swelling 47.63 11.16 61 350819 1199 34604852
Myalgia 47.06 11.16 1141 349739 82969 34523082
Pemphigoid 47.02 11.16 192 350688 8474 34597577
Renal failure 47.00 11.16 1676 349204 128881 34477170
Intentional product use issue 46.65 11.16 380 350500 59436 34546615
Glycosylated haemoglobin increased 46.13 11.16 231 350649 11129 34594922
Hyperdynamic left ventricle 45.94 11.16 27 350853 167 34605884
Pulmonary oedema 45.53 11.16 700 350180 46829 34559222
Chronic pigmented purpura 45.15 11.16 23 350857 102 34605949
Myocardial depression 44.96 11.16 18 350862 38 34606013
Infection 44.54 11.16 643 350237 90272 34515779
Orthostatic hypotension 44.28 11.16 426 350454 25493 34580558
Agitation 44.14 11.16 366 350514 57033 34549018
Cardiac failure congestive 43.73 11.16 1120 349760 82150 34523901
Sedation 43.40 11.16 91 350789 20915 34585136
Bronchopulmonary aspergillosis 43.19 11.16 50 350830 14609 34591442
Renal cell carcinoma 43.17 11.16 130 350750 4918 34601133
Nephrotic syndrome 43 11.16 166 350714 7137 34598914
Palmar-plantar erythrodysaesthesia syndrome 41.52 11.16 300 350580 16495 34589556
Product monitoring error 41.47 11.16 117 350763 4264 34601787
Asthma 41.15 11.16 629 350251 42027 34564024
Infective pulmonary exacerbation of cystic fibrosis 41.03 11.16 9 350871 6792 34599259
Seizure 41.03 11.16 773 350107 104084 34501967
Multiple-drug resistance 41.00 11.16 3 350877 5236 34600815
Interstitial lung disease 40.97 11.16 900 349980 64382 34541669
Mucosal inflammation 40.84 11.16 224 350656 38398 34567653
Erectile dysfunction 40.76 11.16 350 350530 20287 34585764
Post transplant lymphoproliferative disorder 40.71 11.16 8 350872 6520 34599531
Acute graft versus host disease 40.49 11.16 8 350872 6495 34599556
Gingival bleeding 40.31 11.16 158 350722 6842 34599209
Carotid artery stenosis 39.89 11.16 126 350754 4893 34601158
Therapeutic product effect decreased 39.83 11.16 196 350684 34547 34571504
Haemophagocytic lymphohistiocytosis 39.58 11.16 43 350837 12930 34593121
Condition aggravated 39.31 11.16 1554 349326 190642 34415409
Depression 39.17 11.16 712 350168 96386 34509665
5-hydroxyindolacetic acid in urine increased 38.98 11.16 27 350853 230 34605821
Haematotoxicity 38.45 11.16 17 350863 8177 34597874
Atrioventricular block complete 38.20 11.16 190 350690 9129 34596922
Therapy partial responder 37.76 11.16 25 350855 9591 34596460
Sinus bradycardia 37.68 11.16 241 350639 12722 34593329
Suicidal ideation 37.56 11.16 244 350636 40144 34565907
Thalamus haemorrhage 36.96 11.16 48 350832 957 34605094
Myocardial infarction 36.59 11.16 1525 349355 119560 34486491
Contraindicated product administered 36.54 11.16 103 350777 21378 34584673
Cytomegalovirus infection 36.35 11.16 137 350743 25998 34580053
Coronary artery disease 36.28 11.16 684 350196 47621 34558430
Breath sounds abnormal 36.19 11.16 151 350729 6730 34599321
Renal artery stenosis 36.16 11.16 74 350806 2187 34603864
Tachycardia 35.66 11.16 617 350263 84155 34521896
Psychotic disorder 35.45 11.16 126 350754 24326 34581725
Hypomagnesaemia 34.82 11.16 354 350526 21497 34584554
Stenosis 34.71 11.16 57 350823 1416 34604635
Appendicolith 34.26 11.16 22 350858 8579 34597472
Bone marrow failure 34.13 11.16 164 350716 29089 34576962
Irritability 33.97 11.16 130 350750 24560 34581491
Diastolic dysfunction 33.81 11.16 138 350742 6089 34599962
Wrong technique in product usage process 33.16 11.16 218 350662 35768 34570283
Aspergillus infection 32.76 11.16 45 350835 12209 34593842
Tongue oedema 32.34 11.16 84 350796 2913 34603138
Primary hyperaldosteronism 32.30 11.16 16 350864 66 34605985
Congenital hiatus hernia 32.12 11.16 41 350839 803 34605248
Sinusitis 31.83 11.16 264 350616 41138 34564913
Mucormycosis 31.79 11.16 10 350870 5932 34600119
Macroglossia 31.68 11.16 29 350851 382 34605669
Graft versus host disease 31.19 11.16 36 350844 10533 34595518
Loss of consciousness 31.16 11.16 1067 349813 81600 34524451
Hypoglycaemia 31.08 11.16 743 350137 53897 34552154
Acute myocardial infarction 31.02 11.16 732 350148 52987 34553064
Transient ischaemic attack 30.94 11.16 418 350462 27195 34578856
Abnormal behaviour 30.90 11.16 137 350743 24832 34581219
Atrioventricular block first degree 30.73 11.16 132 350748 5960 34600091
Dermatomyositis 30.71 11.16 50 350830 1233 34604818
Cytomegalovirus infection reactivation 30.42 11.16 7 350873 5111 34600940
Chronic graft versus host disease 30.31 11.16 4 350876 4369 34601682
Palpitations 30.30 11.16 567 350313 39419 34566632
Overdose 30.09 11.16 1158 349722 89901 34516150
Injection site pain 29.85 11.16 249 350631 38756 34567295
Substance abuse 29.82 11.16 20 350860 7621 34598430
Bone erosion 29.51 11.16 3 350877 4012 34602039
Acute hepatic failure 29.05 11.16 61 350819 14013 34592038
Product dose omission issue 28.96 11.16 948 349932 118763 34487288
Drug withdrawal syndrome 28.88 11.16 102 350778 19732 34586319
Plasmapheresis 28.84 11.16 25 350855 305 34605746
Neutrophil count decreased 28.82 11.16 351 350529 50753 34555298
Candida infection 28.64 11.16 87 350793 17628 34588423
Immune-mediated myositis 28.51 11.16 64 350816 2019 34604032
Clear cell renal cell carcinoma 27.86 11.16 45 350835 1102 34604949
Dyspnoea 27.68 11.16 4246 346634 372536 34233515
Hypertensive heart disease 27.55 11.16 69 350811 2339 34603712
Polymyositis 27.43 11.16 51 350829 1402 34604649
Hepatojugular reflux 27.43 11.16 32 350848 569 34605482
Arthropathy 27.39 11.16 158 350722 26749 34579302
Blood mercury abnormal 27.35 11.16 21 350859 213 34605838
No adverse event 27.06 11.16 128 350752 22799 34583252
Diabetes mellitus inadequate control 26.93 11.16 229 350651 13235 34592816
Akathisia 26.89 11.16 25 350855 8084 34597967
Psoriatic arthropathy 26.75 11.16 105 350775 19693 34586358
Therapeutic product effect incomplete 26.69 11.16 352 350528 50189 34555862
Peripheral swelling 26.63 11.16 979 349901 75562 34530489
Drug use disorder 26.42 11.16 5 350875 4186 34601865
Hyponatraemia 26.24 11.16 1047 349833 81644 34524407
Vertebral osteophyte 26.18 11.16 13 350867 54 34605997
Adenovirus infection 26.14 11.16 10 350870 5247 34600804
Fall 26.09 11.16 2370 348510 200515 34405536
Electrocardiogram Q wave abnormal 25.84 11.16 27 350853 422 34605629
Blood creatine phosphokinase increased 25.82 11.16 611 350269 44246 34561805
Periodontitis 25.63 11.16 59 350821 1893 34604158
Hospitalisation 25.61 11.16 409 350471 56493 34549558
Accelerated hypertension 25.54 11.16 21 350859 237 34605814
Intentional product misuse 25.45 11.16 314 350566 45297 34560754
Electrocardiogram QRS complex prolonged 25.43 11.16 107 350773 4787 34601264
Pelvic mass 25.26 11.16 20 350860 213 34605838
Gout 25.21 11.16 300 350580 18953 34587098
Paranoia 25.17 11.16 52 350828 12016 34594035
Orbital myositis 24.96 11.16 16 350864 118 34605933
Ventricular septal defect 24.75 11.16 5 350875 3996 34602055
Metastatic renal cell carcinoma 24.58 11.16 60 350820 2001 34604050
Gravitational oedema 24.27 11.16 32 350848 648 34605403
Angina unstable 24.26 11.16 200 350680 11453 34594598
Dyspnoea exertional 24.15 11.16 587 350293 42692 34563359
Hyperplasia 24.04 11.16 30 350850 574 34605477
Myelodysplastic syndrome 24.00 11.16 105 350775 19103 34586948
Oropharyngeal oedema 23.90 11.16 14 350866 86 34605965
Staphylococcal infection 23.79 11.16 212 350668 32548 34573503
Obstructive airways disorder 23.73 11.16 249 350631 15245 34590806
Intercepted product preparation error 23.41 11.16 6 350874 4072 34601979
Maternal exposure during pregnancy 23.40 11.16 10 350870 4908 34601143
Cytomegalovirus chorioretinitis 23.23 11.16 4 350876 3585 34602466
Alcohol abuse 23.19 11.16 9 350871 4681 34601370
Ear infection 23.15 11.16 42 350838 10189 34595862
Carotid arteriosclerosis 23.13 11.16 55 350825 1803 34604248
Lacunar infarction 23.13 11.16 76 350804 3014 34603037
Febrile bone marrow aplasia 23.12 11.16 29 350851 8180 34597871
Carotid sinus syndrome 23.05 11.16 10 350870 28 34606023
Drug intolerance 23.02 11.16 440 350440 59130 34546921
Cognitive disorder 22.95 11.16 181 350699 28512 34577539
Putamen haemorrhage 22.88 11.16 20 350860 247 34605804
Allergy to animal 22.48 11.16 24 350856 385 34605666
Dystonia 22.39 11.16 47 350833 10798 34595253
Skin toxicity 22.33 11.16 10 350870 4774 34601277
Diabetic nephropathy 22.31 11.16 59 350821 2069 34603982
Tenosynovitis 22.22 11.16 9 350871 4561 34601490
Graft versus host disease in skin 22.11 11.16 6 350874 3919 34602132
Dyskinesia 22.08 11.16 133 350747 22280 34583771
Lung diffusion test decreased 21.82 11.16 29 350851 592 34605459
Acidosis 21.80 11.16 186 350694 10759 34595292
Dyspnoea at rest 21.72 11.16 86 350794 3742 34602309
Hypoinsulinaemia 21.67 11.16 6 350874 0 34606051
Lymphadenopathy 21.64 11.16 182 350698 28281 34577770
Hyperlipidaemia 21.55 11.16 232 350648 14297 34591754
BRASH syndrome 21.54 11.16 27 350853 519 34605532
Pseudolymphoma 21.52 11.16 30 350850 642 34605409
Gait spastic 21.36 11.16 39 350841 1057 34604994
Intentional self-injury 21.29 11.16 69 350811 13702 34592349
Pollakiuria 21.29 11.16 296 350584 19378 34586673
Therapy non-responder 21.27 11.16 271 350609 38875 34567176
Oesophageal carcinoma 21.22 11.16 38 350842 9266 34596785
Vomiting 21.21 11.16 2169 348711 245452 34360599
Red blood cell sedimentation rate abnormal 21.15 11.16 5 350875 3584 34602467
Obsessive-compulsive disorder 21.13 11.16 15 350865 5549 34600502
Acute myeloid leukaemia 20.98 11.16 103 350777 18167 34587884
Haemorrhage subcutaneous 20.97 11.16 61 350819 2263 34603788
Device leakage 20.95 11.16 21 350859 6554 34599497
Heart rate decreased 20.66 11.16 440 350440 31305 34574746
Aortic dissection 20.65 11.16 68 350812 2700 34603351
Maternal drugs affecting foetus 20.64 11.16 7 350873 3958 34602093
Eczema 20.62 11.16 279 350601 18157 34587894
Fungal infection 20.59 11.16 86 350794 15849 34590202
Brain stem infarction 20.55 11.16 42 350838 1240 34604811
Lymphoma 20.52 11.16 61 350819 12446 34593605
Device issue 20.50 11.16 42 350838 9735 34596316
Epstein-Barr virus infection 20.40 11.16 28 350852 7600 34598451
Small for dates baby 20.32 11.16 7 350873 3920 34602131
Lymphocele 20.06 11.16 43 350837 1314 34604737
Leukaemoid reaction 20.05 11.16 13 350867 98 34605953
Diffuse large B-cell lymphoma recurrent 20.04 11.16 4 350876 3224 34602827
Mouth swelling 20.01 11.16 52 350828 1804 34604247
Cardiogenic shock 20.01 11.16 377 350503 26241 34579810
Left ventricular hypertrophy 19.96 11.16 145 350735 7985 34598066
Migraine 19.80 11.16 99 350781 17379 34588672
Melaena 19.78 11.16 480 350400 34900 34571151
Apparent death 19.73 11.16 6 350874 3638 34602413
Appendicitis 19.71 11.16 79 350801 14728 34591323
Fibrillary glomerulonephritis 19.69 11.16 10 350870 44 34606007
Hydronephrosis 19.66 11.16 174 350706 10172 34595879
Ventricular hypertrophy 19.64 11.16 95 350785 4512 34601539
Venoocclusive liver disease 19.59 11.16 31 350849 7935 34598116
Blood urea increased 19.16 11.16 419 350461 29945 34576106
Nausea 19.09 11.16 3059 347821 336849 34269202
Microalbuminuria 19.08 11.16 29 350851 673 34605378
Lipodystrophy acquired 19.05 11.16 5 350875 3339 34602712
Swelling face 19.04 11.16 332 350548 22773 34583278
Bundle branch block 18.95 11.16 33 350847 861 34605190
Mydriasis 18.92 11.16 27 350853 7210 34598841
Blood pressure decreased 18.92 11.16 663 350217 50852 34555199
Zoonotic bacterial infection 18.86 11.16 10 350870 49 34606002
Renal disorder 18.51 11.16 359 350521 25121 34580930
Peripheral artery occlusion 18.49 11.16 48 350832 1664 34604387
Asphyxia 18.37 11.16 25 350855 6810 34599241
Duodenal ulcer haemorrhage 18.32 11.16 99 350781 4914 34601137
Pneumonia 18.28 11.16 3283 347597 359344 34246707
Nipple inflammation 18.24 11.16 10 350870 53 34605998
Osteonecrosis 18.24 11.16 82 350798 14808 34591243
Cytomegalovirus viraemia 18.19 11.16 29 350851 7401 34598650
Deep vein thrombosis 18.16 11.16 507 350373 64741 34541310
Euphoric mood 18.00 11.16 18 350862 5623 34600428
Eyelid oedema 17.93 11.16 100 350780 5024 34601027
Neuropathy peripheral 17.91 11.16 669 350211 82594 34523457
Bundle branch block left 17.90 11.16 112 350768 5867 34600184
Drug eruption 17.89 11.16 290 350590 19608 34586443
Myopathy 17.84 11.16 186 350694 11368 34594683
Epiglottic oedema 17.78 11.16 15 350865 176 34605875
Product substitution issue 17.77 11.16 167 350713 9928 34596123
Neurotoxicity 17.67 11.16 107 350773 17903 34588148
Atrioventricular block 17.66 11.16 140 350740 7923 34598128
Oedema 17.63 11.16 592 350288 45149 34560902
Presyncope 17.60 11.16 279 350601 18780 34587271
Micturition urgency 17.56 11.16 119 350761 6406 34599645
Dysmorphism 17.45 11.16 5 350875 3151 34602900
Incorrect route of product administration 17.45 11.16 83 350797 14762 34591289
Anxiety 17.36 11.16 818 350062 98610 34507441
Pericardial disease 17.35 11.16 22 350858 428 34605623
Hepatic failure 17.33 11.16 243 350637 34288 34571763
Chills 17.24 11.16 652 350228 80391 34525660
Cerebral haemorrhage 17.19 11.16 466 350414 34471 34571580
Pain 17.08 11.16 1796 349084 202879 34403172
Discomfort 17.02 11.16 276 350604 18662 34587389
Hepatic neoplasm 16.99 11.16 51 350829 1926 34604125
Helicobacter gastritis 16.94 11.16 38 350842 1198 34604853
Peripheral arterial occlusive disease 16.94 11.16 109 350771 5765 34600286
Nasal crusting 16.91 11.16 20 350860 361 34605690
Diabetic neuropathy 16.80 11.16 85 350795 4112 34601939
Graft versus host disease in gastrointestinal tract 16.72 11.16 8 350872 3675 34602376
Hypersensitivity vasculitis 16.62 11.16 72 350808 3263 34602788
Blood glucose increased 16.59 11.16 824 350056 65894 34540157
Hypertensive emergency 16.59 11.16 34 350846 1006 34605045
Hepatic function abnormal 16.55 11.16 572 350308 43791 34562260
Respiratory alkalosis 16.53 11.16 46 350834 1663 34604388
Pseudomonas infection 16.52 11.16 66 350814 12316 34593735
Haemodialysis 16.52 11.16 170 350710 10356 34595695
Milk-alkali syndrome 16.45 11.16 25 350855 580 34605471
Hepatocellular carcinoma 16.24 11.16 130 350750 7379 34598672
Hypocalcaemia 16.24 11.16 338 350542 23951 34582100
Cardiac dysfunction 16.17 11.16 56 350824 2282 34603769
Atrial septal defect 16.15 11.16 31 350849 7361 34598690
Renal function test abnormal 16.13 11.16 59 350821 2471 34603580
Pulmonary embolism 16.13 11.16 736 350144 89010 34517041
Viral infection 16.11 11.16 107 350773 17516 34588535
Pharyngeal oedema 16.11 11.16 110 350770 5937 34600114
Body temperature increased 16.10 11.16 105 350775 17263 34588788
Alanine aminotransferase abnormal 16.09 11.16 14 350866 4674 34601377
Muscle rigidity 16.06 11.16 53 350827 10465 34595586
Blood pressure diastolic decreased 15.79 11.16 150 350730 8944 34597107
Atheroembolism 15.78 11.16 18 350862 312 34605739
Liver carcinoma ruptured 15.75 11.16 14 350866 177 34605874
Blood pressure abnormal 15.75 11.16 137 350743 7969 34598082
Electrocardiogram P wave abnormal 15.72 11.16 13 350867 148 34605903
Low birth weight baby 15.70 11.16 35 350845 7870 34598181
Rheumatoid nodule 15.69 11.16 5 350875 2942 34603109
Forced vital capacity decreased 15.62 11.16 28 350852 748 34605303
Enterococcal infection 15.55 11.16 45 350835 9261 34596790
Psychomotor skills impaired 15.55 11.16 10 350870 3896 34602155
Therapeutic response decreased 15.53 11.16 204 350676 29109 34576942
Hepatic fibrosis 15.52 11.16 14 350866 4593 34601458
Low density lipoprotein decreased 15.51 11.16 35 350845 1108 34604943
Needle fatigue 15.49 11.16 30 350850 851 34605200
Hyperglycaemia 15.48 11.16 512 350368 38968 34567083
Mitral valve incompetence 15.44 11.16 223 350657 14720 34591331
Chronic obstructive pulmonary disease 15.42 11.16 619 350261 48299 34557752
Cardiomegaly 15.41 11.16 229 350651 15209 34590842
COVID-19 15.39 11.16 629 350251 76921 34529130
Herbal interaction 15.36 11.16 19 350861 360 34605691
Giant cell arteritis 15.28 11.16 29 350851 810 34605241
Kidney small 15.27 11.16 9 350871 56 34605995
Prostate cancer 15.27 11.16 293 350587 39356 34566695
Intervertebral disc displacement 15.22 11.16 12 350868 127 34605924
Pulmonary valve disease 15.22 11.16 18 350862 325 34605726
Toxic skin eruption 15.17 11.16 178 350702 11207 34594844
Tricuspid valve calcification 15.16 11.16 5 350875 4 34606047
Virologic failure 15.14 11.16 8 350872 3472 34602579
Dermatitis infected 15.13 11.16 11 350869 102 34605949
Hepatitis 15.11 11.16 160 350720 23744 34582307
Sprue-like enteropathy 15.10 11.16 22 350858 491 34605560
Respiratory failure 15.05 11.16 914 349966 107658 34498393
Haemodynamic instability 15.04 11.16 154 350726 9369 34596682
Tricuspid valve incompetence 15.02 11.16 157 350723 9603 34596448
Left ventricular enlargement 14.99 11.16 26 350854 676 34605375
Cerebellar haemorrhage 14.91 11.16 42 350838 1529 34604522
Product solubility abnormal 14.90 11.16 22 350858 497 34605554
Band neutrophil percentage decreased 14.88 11.16 6 350874 13 34606038
Pericardial haemorrhage 14.85 11.16 67 350813 3091 34602960
High density lipoprotein decreased 14.84 11.16 70 350810 3290 34602761
Yellow skin 14.83 11.16 51 350829 2071 34603980
Osteoporosis 14.79 11.16 71 350809 12597 34593454
Tremor 14.70 11.16 678 350202 81909 34524142
Hyperuricaemia 14.64 11.16 134 350746 7909 34598142
Device use error 14.62 11.16 3 350877 2372 34603679
Drug level decreased 14.58 11.16 36 350844 7810 34598241
Hypospadias 14.46 11.16 7 350873 3194 34602857
Uveitis 14.45 11.16 34 350846 7501 34598550
Basophil percentage increased 14.45 11.16 4 350876 0 34606051
Mucosal membrane hyperplasia 14.45 11.16 4 350876 0 34606051
Ventricular compliance decreased 14.45 11.16 4 350876 0 34606051
Glomerular filtration rate decreased 14.43 11.16 196 350684 12765 34593286
Hepatic enzyme increased 14.38 11.16 291 350589 38789 34567262
Monoparesis 14.37 11.16 54 350826 2292 34603759
Encephalitis toxic 14.27 11.16 16 350864 272 34605779
Anal abscess 14.27 11.16 27 350853 6446 34599605
Atrial fibrillation 14.26 11.16 1420 349460 120973 34485078
Tubulointerstitial nephritis 14.20 11.16 293 350587 20731 34585320
Respiratory arrest 14.19 11.16 197 350683 27846 34578205
Muscle necrosis 14.17 11.16 29 350851 857 34605194
Chest discomfort 14.08 11.16 676 350204 53854 34552197
Decreased appetite 14.07 11.16 1891 348989 164501 34441550
Sickle cell anaemia with crisis 14.03 11.16 12 350868 4041 34602010
Noninfective gingivitis 13.97 11.16 18 350862 356 34605695
Blood potassium increased 13.94 11.16 238 350642 16257 34589794
Acute coronary syndrome 13.94 11.16 202 350678 13343 34592708
Antipsychotic drug level increased 13.93 11.16 11 350869 3854 34602197
Abscess 13.93 11.16 66 350814 11751 34594300
Miosis 13.91 11.16 49 350831 9486 34596565
Nephrogenic systemic fibrosis 13.90 11.16 78 350802 3927 34602124
Blood potassium decreased 13.90 11.16 255 350625 17660 34588391
Neonatal respiratory distress syndrome 13.90 11.16 12 350868 4022 34602029
Malignant neoplasm progression 13.88 11.16 732 350148 87314 34518737
Lacrimal disorder 13.87 11.16 17 350863 319 34605732
Brain abscess 13.87 11.16 7 350873 3118 34602933
White blood cell count decreased 13.85 11.16 800 350080 94645 34511406
Hepatic cytolysis 13.77 11.16 87 350793 14409 34591642
Left atrial enlargement 13.75 11.16 29 350851 876 34605175
Thrombotic cerebral infarction 13.74 11.16 18 350862 362 34605689
Strongyloidiasis 13.74 11.16 5 350875 2706 34603345
Pneumocystis jirovecii pneumonia 13.68 11.16 129 350751 19581 34586470
Sinus node dysfunction 13.61 11.16 81 350799 4168 34601883
Hypertensive encephalopathy 13.60 11.16 18 350862 366 34605685
Full blood count abnormal 13.55 11.16 263 350617 18405 34587646
Toxic nodular goitre 13.53 11.16 6 350874 18 34606033
Chest pain 13.53 11.16 1462 349418 125300 34480751
Neuroleptic malignant syndrome 13.49 11.16 115 350765 17819 34588232
Prostate cancer stage IV 13.48 11.16 4 350876 2464 34603587
Histology abnormal 13.48 11.16 16 350864 290 34605761
Weight increased 13.46 11.16 780 350100 92253 34513798
Pelvic cyst 13.41 11.16 7 350873 33 34606018
Hypothyroidism 13.37 11.16 289 350591 20613 34585438
Polypectomy 13.35 11.16 22 350858 548 34605503
Cachexia 13.33 11.16 33 350847 7153 34598898
Pneumonia cytomegaloviral 13.32 11.16 7 350873 3047 34603004
Inappropriate schedule of product administration 13.29 11.16 501 350379 61795 34544256
Anal fistula 13.29 11.16 21 350859 5378 34600673
Cutaneous lupus erythematosus 13.27 11.16 26 350854 744 34605307
Blood pressure systolic decreased 13.26 11.16 84 350796 4419 34601632
Splenic cyst 13.18 11.16 11 350869 127 34605924
Musculoskeletal stiffness 13.17 11.16 362 350518 46318 34559733
Nodal rhythm 13.14 11.16 38 350842 1405 34604646
Hyperthermia 13.11 11.16 58 350822 10519 34595532
Drug interaction 13.08 11.16 2515 348365 223431 34382620
Blood aldosterone increased 13.07 11.16 6 350874 20 34606031
Thromboangiitis obliterans 13.07 11.16 6 350874 20 34606031
Thrombotic stroke 13.06 11.16 15 350865 262 34605789
Hair colour changes 13.02 11.16 45 350835 1832 34604219
Sex hormone binding globulin increased 13 11.16 5 350875 9 34606042
Relapsing-remitting multiple sclerosis 12.99 11.16 31 350849 1019 34605032
Fracture displacement 12.98 11.16 10 350870 102 34605949
Intestinal stenosis 12.97 11.16 3 350877 2183 34603868
Suspected suicide attempt 12.97 11.16 11 350869 130 34605921
Lymphomatoid papulosis 12.97 11.16 13 350867 193 34605858
Immunodeficiency 12.96 11.16 22 350858 5476 34600575
Hand deformity 12.93 11.16 11 350869 3714 34602337
Hyperthermia malignant 12.90 11.16 3 350877 2174 34603877
Aortic aneurysm 12.88 11.16 114 350766 6665 34599386
Status epilepticus 12.87 11.16 74 350806 12540 34593511
Cardiovascular disorder 12.86 11.16 156 350724 9900 34596151
Post-traumatic amnestic disorder 12.82 11.16 8 350872 56 34605995
Hyperammonaemia 12.80 11.16 28 350852 6339 34599712
Asthma-chronic obstructive pulmonary disease overlap syndrome 12.80 11.16 35 350845 1252 34604799
Depressed level of consciousness 12.79 11.16 539 350341 42302 34563749
Generalised oedema 12.75 11.16 185 350695 12223 34593828
Hyperbilirubinaemia 12.67 11.16 108 350772 16735 34589316
Coronary artery stenosis 12.66 11.16 150 350730 9466 34596585
Retinopathy hypertensive 12.63 11.16 15 350865 272 34605779
Prostate cancer recurrent 12.63 11.16 30 350850 983 34605068
Ischaemia 12.61 11.16 84 350796 4496 34601555
Coma scale abnormal 12.58 11.16 76 350804 3932 34602119
Gastric ulcer haemorrhage 12.58 11.16 96 350784 5370 34600681
Glomerulonephritis acute 12.57 11.16 11 350869 136 34605915
Macrophages increased 12.53 11.16 12 350868 168 34605883
Upper respiratory tract infection 12.52 11.16 245 350635 32814 34573237
Lymphocyte count decreased 12.51 11.16 156 350724 22466 34583585
Lung operation 12.50 11.16 9 350871 82 34605969
Ventricular hyperkinesia 12.45 11.16 13 350867 203 34605848
Crying 12.44 11.16 25 350855 5837 34600214
Toxicity to various agents 12.41 11.16 2238 348642 198124 34407927
Intraventricular haemorrhage 12.41 11.16 69 350811 3462 34602589
Hypertonic bladder 12.34 11.16 44 350836 1820 34604231
Renal mass 12.30 11.16 43 350837 1761 34604290
Respiratory depression 12.29 11.16 104 350776 16141 34589910
Flour sensitivity 12.25 11.16 6 350874 24 34606027
Occult blood 12.25 11.16 27 350853 841 34605210
Blood cholinesterase decreased 12.19 11.16 11 350869 142 34605909
Stomatitis 12.17 11.16 329 350551 42185 34563866
Snoring 12.17 11.16 66 350814 3280 34602771
Peripheral artery stenosis 12.17 11.16 27 350853 845 34605206
Blister 12.14 11.16 308 350572 22550 34583501
Seronegative arthritis 12.13 11.16 30 350850 1009 34605042
Metastases to central nervous system 12.08 11.16 42 350838 8163 34597888
Oliguria 12.06 11.16 133 350747 8247 34597804
Tardive dyskinesia 12.03 11.16 25 350855 5765 34600286
Injection site reaction 11.98 11.16 79 350801 12954 34593097
Drug dispensed to wrong patient 11.97 11.16 20 350860 504 34605547
Prerenal failure 11.97 11.16 47 350833 2037 34604014
Lung hernia 11.96 11.16 8 350872 64 34605987
Arterial stenosis 11.89 11.16 32 350848 1134 34604917
Multiple sclerosis relapse 11.87 11.16 80 350800 13053 34592998
Pain in extremity 11.86 11.16 1447 349433 125066 34480985
Somnolence 11.85 11.16 957 349923 110159 34495892
Mean platelet volume increased 11.81 11.16 20 350860 510 34605541
Pericarditis uraemic 11.78 11.16 5 350875 13 34606038
Altered state of consciousness 11.73 11.16 307 350573 22586 34583465
Wheezing 11.71 11.16 518 350362 40884 34565167
Renal transplant 11.69 11.16 43 350837 1806 34604245
Hypercholesterolaemia 11.67 11.16 137 350743 8625 34597426
Transaminases increased 11.66 11.16 194 350686 26629 34579422
Mean arterial pressure decreased 11.66 11.16 11 350869 151 34605900
Lipoma 11.64 11.16 41 350839 1685 34604366
Ventricular tachycardia 11.64 11.16 192 350688 26387 34579664
Bile duct stone 11.61 11.16 54 350826 2523 34603528
Joint swelling 11.61 11.16 723 350157 59167 34546884
Ultrafiltration failure 11.60 11.16 11 350869 152 34605899
Serotonin syndrome 11.58 11.16 136 350744 19797 34586254
Hypertensive nephropathy 11.57 11.16 19 350861 472 34605579
Blood pressure orthostatic 11.56 11.16 8 350872 68 34605983
Infusion site extravasation 11.56 11.16 16 350864 4328 34601723
Dysgeusia 11.53 11.16 348 350532 26149 34579902
Cold sweat 11.52 11.16 152 350728 9835 34596216
Renal artery thrombosis 11.52 11.16 15 350865 300 34605751
Polyomavirus-associated nephropathy 11.44 11.16 13 350867 3831 34602220
Sinonasal obstruction 11.38 11.16 8 350872 70 34605981
Renin increased 11.36 11.16 9 350871 96 34605955
Electrocardiogram T wave amplitude decreased 11.35 11.16 16 350864 346 34605705
Malaise 11.33 11.16 2074 348806 183751 34422300
Physical examination abnormal 11.33 11.16 15 350865 305 34605746
Retinal vascular thrombosis 11.28 11.16 8 350872 71 34605980
Rhinovirus infection 11.28 11.16 16 350864 4283 34601768
Diabetic retinopathy 11.27 11.16 42 350838 1775 34604276
Epilepsy 11.24 11.16 150 350730 21345 34584706
Phaeochromocytoma malignant 11.19 11.16 8 350872 72 34605979
Polymyalgia rheumatica 11.18 11.16 37 350843 1473 34604578
Acute lung injury 11.18 11.16 37 350843 1473 34604578
Periodontal disease 11.17 11.16 25 350855 787 34605264
Angiopathy 11.17 11.16 76 350804 4097 34601954

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 1494.01 10.06 4996 664001 240771 78834620
Hypotension 1007.48 10.06 6729 662268 433588 78641803
Drug ineffective 989.91 10.06 5196 663801 1075717 77999674
Off label use 763.00 10.06 4482 664515 902733 78172658
Shock 733.95 10.06 1314 667683 42234 79033157
Synovitis 728.69 10.06 183 668814 150551 78924840
Acute kidney injury 711.78 10.06 7064 661933 512340 78563051
Gingival hypertrophy 706.18 10.06 397 668600 2745 79072646
Anti-cyclic citrullinated peptide antibody positive 649.71 10.06 9 668988 83134 78992257
Hand deformity 641.15 10.06 64 668933 103855 78971536
Pemphigus 625.84 10.06 57 668940 99525 78975866
Maternal exposure during pregnancy 614.80 10.06 190 668807 136348 78939043
Contraindicated product administered 606.38 10.06 281 668716 157257 78918134
Bradycardia 603.92 10.06 2495 666502 133062 78942329
Treatment failure 589.85 10.06 349 668648 170137 78905254
Drug intolerance 574.18 10.06 828 668169 263291 78812100
Infusion related reaction 536.55 10.06 686 668311 229551 78845840
Systemic lupus erythematosus 525.29 10.06 180 668817 120969 78954422
Intentional overdose 518.96 10.06 2009 666988 103951 78971440
Arthropathy 509.97 10.06 441 668556 176670 78898721
Pericarditis 506.72 10.06 125 668872 104111 78971280
Therapeutic product effect decreased 499.15 10.06 386 668611 163477 78911914
Drug abuse 475.85 10.06 399 668598 162292 78913099
Glossodynia 473.88 10.06 139 668858 103198 78972193
Oedema peripheral 444.86 10.06 3627 665370 248661 78826730
Non-cardiogenic pulmonary oedema 433.71 10.06 224 668773 1275 79074116
Blood pressure inadequately controlled 423.04 10.06 377 668620 5800 79069591
Blood pressure increased 385.74 10.06 3063 665934 208297 78867094
Duodenal ulcer perforation 385.26 10.06 50 668947 66161 79009230
Helicobacter infection 381.60 10.06 63 668934 69641 79005750
Alopecia 380.94 10.06 861 668136 230494 78844897
Hyponatraemia 369.89 10.06 2658 666339 175190 78900201
Distributive shock 364.51 10.06 246 668751 2441 79072950
Orthostatic hypotension 350.34 10.06 1153 667844 55011 79020380
Cerebrovascular accident 347.03 10.06 2362 666635 152930 78922461
Wound 347.03 10.06 279 668718 115900 78959491
Renal impairment 346.73 10.06 2390 666607 155393 78919998
Hepatic enzyme increased 340.99 10.06 632 668365 181978 78893413
C-reactive protein abnormal 338.15 10.06 16 668981 48351 79027040
Fall 337.82 10.06 5856 663141 481773 78593618
Folliculitis 334.12 10.06 37 668960 55343 79020048
Vasoplegia syndrome 330.21 10.06 261 668736 3369 79072022
Hyperkalaemia 326.45 10.06 1853 667144 112545 78962846
Rheumatoid arthritis 325.45 10.06 798 668199 207672 78867719
Sleep disorder due to general medical condition, insomnia type 323.16 10.06 9 668988 43547 79031844
Angioedema 311.72 10.06 1365 667632 74670 79000721
Hypersensitivity 311.37 10.06 1140 667857 261099 78814292
Hypertensive crisis 307.64 10.06 593 668404 20177 79055214
Rheumatoid factor positive 302.24 10.06 66 668931 59773 79015618
Product use issue 294.29 10.06 847 668150 208975 78866416
Metabolic acidosis 290.60 10.06 1417 667580 81112 78994279
Lactic acidosis 280.01 10.06 1252 667745 69107 79006284
Exposure during pregnancy 280.00 10.06 261 668736 100871 78974520
Muscle injury 274.66 10.06 40 668957 48521 79026870
Product use in unapproved indication 265.63 10.06 1138 667859 249221 78826170
Hypokalaemia 249.92 10.06 2064 666933 141976 78933415
Sinusitis 244.61 10.06 831 668166 194670 78880721
Irritable bowel syndrome 244.09 10.06 108 668889 62133 79013258
Toxicity to various agents 239.10 10.06 4910 664087 416630 78658761
Syncope 235.75 10.06 2422 666575 177027 78898364
Discomfort 223.75 10.06 447 668550 125170 78950221
Rheumatic fever 223.21 10.06 3 668994 28522 79046869
Blood creatinine increased 221.70 10.06 2130 666867 152927 78922464
Infection 220.46 10.06 1160 667837 240552 78834839
Rhabdomyolysis 215.79 10.06 1544 667453 101587 78973804
Impaired healing 212.59 10.06 253 668744 87402 78987989
Cerebral infarction 210.56 10.06 850 668147 44826 79030565
Pain 208.84 10.06 4411 664586 699391 78376000
Fibromyalgia 205.61 10.06 144 668853 64196 79011195
Psoriatic arthropathy 202.44 10.06 213 668784 77786 78997605
Cardiac failure congestive 198.57 10.06 1946 667051 140456 78934935
Hypoglycaemia 191.56 10.06 1484 667513 100110 78975281
Arthralgia 179.17 10.06 3551 665446 568252 78507139
Angina pectoris 179.05 10.06 884 668113 50848 79024543
Therapeutic product effect incomplete 178.55 10.06 600 668397 141045 78934346
Condition aggravated 178.23 10.06 3044 665953 498080 78577311
Dizziness 178.15 10.06 5724 663273 520717 78554674
Abdominal discomfort 176.90 10.06 1303 667694 249424 78825967
Renal failure 175.31 10.06 2510 666487 198458 78876933
Musculoskeletal stiffness 172.04 10.06 818 668179 174190 78901201
Intentional product use issue 171.50 10.06 675 668322 151437 78923954
Neutropenia 169.86 10.06 1568 667429 286142 78789249
Overdose 167.23 10.06 2317 666680 181889 78893502
Swelling 166.74 10.06 1098 667899 215613 78859778
Febrile neutropenia 165.59 10.06 1195 667802 229804 78845587
Depressed level of consciousness 163.86 10.06 1378 667619 95274 78980117
Pregnancy 159.31 10.06 19 668978 26832 79048559
Swollen joint count increased 158.93 10.06 8 668989 22919 79052472
Myocardial infarction 157.53 10.06 2292 666705 181837 78893554
Lower respiratory tract infection 156.36 10.06 557 668440 128663 78946728
Red blood cell sedimentation rate abnormal 153.09 10.06 5 668992 20958 79054433
Creatinine renal clearance decreased 149.26 10.06 423 668574 18579 79056812
Chronic kidney disease 148.10 10.06 1007 667990 65147 79010244
Swollen tongue 147.00 10.06 727 668270 41843 79033548
Coronary artery disease 143.81 10.06 992 668005 64482 79010909
Stomatitis 143.61 10.06 687 668310 146070 78929321
Abortion spontaneous 136.50 10.06 39 668958 29468 79045923
Suspected suicide 135.17 10.06 284 668713 10292 79065099
Suicide attempt 135.10 10.06 1172 667825 81760 78993631
Ill-defined disorder 134.75 10.06 215 668782 65660 79009731
Atrial fibrillation 132.44 10.06 2365 666632 195521 78879870
Device expulsion 127.63 10.06 30 668967 25831 79049560
Proteinuria 126.01 10.06 574 668423 31928 79043463
Atrioventricular block complete 125.86 10.06 365 668632 16245 79059146
Pulmonary oedema 124.91 10.06 1210 667787 87044 78988347
Pyrexia 123.78 10.06 4553 664444 674156 78401235
Drug resistance 122.75 10.06 104 668893 42109 79033282
Hypomagnesaemia 120.91 10.06 740 668257 46171 79029220
Drug interaction 120.30 10.06 4435 664562 410748 78664643
Sedation complication 119.38 10.06 345 668652 15324 79060067
Sinus bradycardia 118.88 10.06 473 668524 24774 79050617
Injection site erythema 117.52 10.06 305 668692 77892 78997499
Injection site reaction 116.66 10.06 174 668823 54611 79020780
Joint swelling 116.29 10.06 1712 667285 286934 78788457
Gastrointestinal disorder 114.98 10.06 580 668417 121625 78953766
Balance disorder 114.75 10.06 1302 667695 97555 78977836
Acute myocardial infarction 113.38 10.06 1065 667932 75971 78999420
Neurologic neglect syndrome 111.95 10.06 130 668867 2777 79072614
Hip arthroplasty 110.36 10.06 83 668914 35673 79039718
Injection site pain 108.00 10.06 642 668355 129196 78946195
Myelosuppression 104.59 10.06 110 668887 40186 79035205
Cardiogenic shock 104.15 10.06 655 668342 41259 79034132
Drug dependence 101.72 10.06 115 668882 40654 79034737
Blood pressure systolic increased 101.56 10.06 932 668065 66054 79009337
Carotid artery thrombosis 100.36 10.06 126 668871 2927 79072464
Live birth 100.25 10.06 18 668979 18726 79056665
Atrioventricular block first degree 99.02 10.06 279 668718 12212 79063179
Rash 98.25 10.06 3912 665085 574446 78500945
Sprue-like enteropathy 93.36 10.06 82 668915 1236 79074155
Dyspnoea 91.79 10.06 8362 660635 848663 78226728
Weight increased 91.72 10.06 1706 667291 275680 78799711
Pemphigoid 91.55 10.06 310 668687 15005 79060386
Anuria 90.99 10.06 383 668614 20580 79054811
Product monitoring error 89.10 10.06 217 668780 8689 79066702
Blood calcium decreased 87.15 10.06 510 668487 31309 79044082
Migraine 86.49 10.06 408 668589 87085 78988306
Diabetes mellitus inadequate control 86.36 10.06 418 668579 23846 79051545
Decreased appetite 85.79 10.06 3601 665396 338817 78736574
Hypertensive emergency 85.34 10.06 111 668886 2674 79072717
Palpitations 84.95 10.06 1514 667483 125096 78950295
Transient ischaemic attack 84.40 10.06 742 668255 51953 79023438
Loss of consciousness 83.05 10.06 1919 667078 166024 78909367
Facet joint syndrome 81.46 10.06 3 668994 11299 79064092
Hyperglycaemia 81.00 10.06 925 668072 69410 79005981
Renin increased 80.95 10.06 40 668957 204 79075187
Blood pressure decreased 78.72 10.06 1222 667775 98244 78977147
Hemiplegia 78.64 10.06 290 668707 14649 79060742
Lip swelling 78.41 10.06 600 668397 40311 79035080
Nasopharyngitis 77.36 10.06 1583 667414 252298 78823093
Intentional self-injury 77.07 10.06 95 668902 32324 79043067
Asthenia 76.98 10.06 5128 663869 506561 78568830
Blister 76.21 10.06 638 668359 118838 78956553
Carotid artery stenosis 75.78 10.06 202 668795 8556 79066835
Nocturia 74.91 10.06 269 668728 13412 79061979
Hyperdynamic left ventricle 74.87 10.06 45 668952 358 79075033
Pathogen resistance 74.10 10.06 15 668982 14327 79061064
Deep vein thrombosis postoperative 73.74 10.06 4 668993 10748 79064643
Knee arthroplasty 73.50 10.06 158 668839 43090 79032301
Wrong technique in product usage process 72.13 10.06 346 668651 73529 79001862
Renal artery stenosis 71.81 10.06 115 668882 3367 79072024
Atrioventricular block 70.95 10.06 269 668728 13772 79061619
Erectile dysfunction 70.87 10.06 277 668720 14387 79061004
Cytomegalovirus infection 70.66 10.06 158 668839 42486 79032905
Hypertension 69.85 10.06 3421 665576 327571 78747820
Blood creatine phosphokinase increased 69.84 10.06 855 668142 65235 79010156
Gingival bleeding 69.58 10.06 296 668701 15980 79059411
Breast cancer stage III 69.50 10.06 3 668994 9823 79065568
Infective pulmonary exacerbation of cystic fibrosis 69.47 10.06 12 668985 12839 79062552
Tenosynovitis 69.33 10.06 22 668975 15532 79059859
Oliguria 68.49 10.06 295 668702 16014 79059377
Dehydration 68.36 10.06 2637 666360 245550 78829841
Dysarthria 68.11 10.06 867 668130 66755 79008636
Melaena 67.09 10.06 794 668203 60096 79015295
Product prescribing error 66.16 10.06 620 668377 44193 79031198
Glycosylated haemoglobin increased 65.83 10.06 328 668669 18932 79056459
Angina unstable 65.65 10.06 294 668703 16233 79059158
Interstitial lung disease 65.40 10.06 1317 667680 111283 78964108
Circulatory collapse 65.38 10.06 540 668457 37128 79038263
Cardiac failure 65.11 10.06 1731 667266 153111 78922280
Left ventricular hypertrophy 64.68 10.06 224 668773 10967 79064424
Hepatic function abnormal 64.03 10.06 914 668083 72193 79003198
Gingival swelling 63.90 10.06 128 668869 4481 79070910
Drug ineffective for unapproved indication 63.87 10.06 218 668779 51020 79024371
BRASH syndrome 63.62 10.06 59 668938 958 79074433
Aortic dissection 62.80 10.06 120 668877 4055 79071336
Immune reconstitution inflammatory syndrome 62.73 10.06 19 668978 13822 79061569
Ear infection 62.59 10.06 121 668876 34311 79041080
Disability 62.10 10.06 33 668964 17087 79058304
Blood urea increased 61.84 10.06 654 668343 48136 79027255
Hyperlipidaemia 61.28 10.06 402 668595 25691 79049700
Chronic pigmented purpura 61.05 10.06 33 668964 209 79075182
Personality disorder 60.69 10.06 149 668848 5997 79069394
Myalgia 60.60 10.06 2011 666986 183630 78891761
Adjustment disorder 60.21 10.06 115 668882 3885 79071506
Grip strength decreased 59.85 10.06 57 668940 21812 79053579
Myocardial depression 59.09 10.06 43 668954 486 79074905
Urticaria 58.42 10.06 1148 667849 184053 78891338
Injection site pruritus 58.25 10.06 172 668825 42111 79033280
Therapy partial responder 58.18 10.06 37 668960 17360 79058031
Hypocalcaemia 57.22 10.06 656 668341 49268 79026123
Liver injury 57.13 10.06 262 668735 56352 79019039
Septic shock 56.36 10.06 709 668288 122092 78953299
Injection site bruising 56.33 10.06 167 668830 40835 79034556
Nephrotic syndrome 55.57 10.06 213 668784 10961 79064430
Body temperature increased 55.37 10.06 189 668808 44231 79031160
Immunodeficiency 54.74 10.06 61 668936 21707 79053684
Haematotoxicity 54.71 10.06 31 668966 15488 79059903
Leukopenia 54.49 10.06 670 668327 115843 78959548
Bursitis 54.46 10.06 139 668858 35705 79039686
Hemiparesis 54.02 10.06 475 668522 33258 79042133
Injection site swelling 53.82 10.06 208 668789 46924 79028467
Foot deformity 53.68 10.06 74 668923 24000 79051391
Hepatotoxicity 53.41 10.06 235 668762 51117 79024274
Post transplant lymphoproliferative disorder 53.31 10.06 15 668982 11449 79063942
Lacunar infarction 53.17 10.06 139 668858 5818 79069573
Hypertensive heart disease 52.65 10.06 112 668885 4094 79071297
Altered state of consciousness 52.57 10.06 581 668416 43241 79032150
Prescribed overdose 52.26 10.06 154 668843 37729 79037662
Therapeutic response decreased 52.23 10.06 337 668660 66516 79008875
Tongue oedema 51.63 10.06 154 668843 6963 79068428
Renal cell carcinoma 51.24 10.06 146 668851 6432 79068959
Dislocation of vertebra 50.89 10.06 4 668993 7876 79067515
Bone marrow failure 50.69 10.06 238 668759 50869 79024522
Cytokine release syndrome 50.63 10.06 145 668852 35853 79039538
Adjustment disorder with depressed mood 50.19 10.06 8 668989 9078 79066313
Haemorrhage subcutaneous 50.07 10.06 119 668878 4690 79070701
Anaemia 50.01 10.06 4359 664638 440656 78634735
Blood glucose increased 49.68 10.06 1290 667707 113685 78961706
Eating disorder 48.68 10.06 319 668678 20378 79055013
Glomerular filtration rate decreased 48.68 10.06 342 668655 22360 79053031
Anti-neutrophil cytoplasmic antibody positive vasculitis 48.66 10.06 101 668896 3628 79071763
Bone erosion 48.28 10.06 47 668950 17800 79057591
Rheumatoid nodule 48.25 10.06 45 668952 17393 79057998
Thrombocytopenia 48.02 10.06 1780 667217 263479 78811912
Injury 47.99 10.06 417 668580 77079 78998312
Renal disorder 47.69 10.06 552 668445 41553 79033838
Breast cancer stage II 47.55 10.06 6 668991 8114 79067277
Injection site warmth 47.48 10.06 33 668964 14774 79060617
Device adhesion issue 47.40 10.06 3 668994 7072 79068319
Lip dry 47.31 10.06 36 668961 15382 79060009
Blood cholesterol increased 47.30 10.06 461 668536 83259 78992132
Subacute cutaneous lupus erythematosus 47.12 10.06 97 668900 3464 79071927
Blood potassium decreased 46.69 10.06 596 668401 45916 79029475
Haemodynamic instability 46.57 10.06 277 668720 17105 79058286
Lung diffusion test abnormal 46.54 10.06 33 668964 357 79075034
Disease progression 46.13 10.06 1185 667812 183177 78892214
Multiple-drug resistance 45.95 10.06 9 668988 8799 79066592
Carotid arteriosclerosis 45.83 10.06 81 668916 2575 79072816
Nodal rhythm 45.80 10.06 89 668908 3046 79072345
Inflammation 45.40 10.06 535 668462 93218 78982173
Gravitational oedema 45.36 10.06 66 668931 1773 79073618
Tubulointerstitial nephritis 44.99 10.06 505 668492 37730 79037661
Acute graft versus host disease 44.23 10.06 15 668982 10152 79065239
Acute hepatic failure 44.06 10.06 119 668878 29994 79045397
Haemophagocytic lymphohistiocytosis 43.97 10.06 72 668925 21765 79053626
Haemodialysis 43.94 10.06 282 668715 17886 79057505
Aggression 43.94 10.06 249 668748 50709 79024682
Cerebral haemorrhage 43.90 10.06 704 668293 56969 79018422
Swelling face 43.38 10.06 839 668158 70373 79005018
Dyspnoea exertional 43.34 10.06 996 668001 86077 78989314
Periodontitis 43.34 10.06 108 668889 4388 79071003
Pseudolymphoma 43.28 10.06 52 668945 1153 79074238
5-hydroxyindolacetic acid in urine increased 43.21 10.06 27 668970 232 79075159
Mucosal inflammation 43.19 10.06 415 668582 75165 79000226
Adverse event 42.84 10.06 312 668685 59902 79015489
Haematemesis 42.84 10.06 646 668351 51618 79023773
Product substitution issue 42.76 10.06 304 668693 19952 79055439
Joint range of motion decreased 42.58 10.06 140 668857 33142 79042249
Hepatocellular carcinoma 42.46 10.06 169 668828 8852 79066539
Gastrointestinal tract mucosal pigmentation 42.19 10.06 48 668949 1002 79074389
Osteoporosis 42.15 10.06 273 668724 53839 79021552
Mitral valve incompetence 42.06 10.06 395 668602 28170 79047221
Aspergillus infection 41.63 10.06 60 668937 19101 79056290
Autoimmune disorder 41.28 10.06 47 668950 16565 79058826
Pollakiuria 41.27 10.06 487 668510 36830 79038561
Therapy non-responder 41.21 10.06 536 668461 91769 78983622
Arteriosclerosis 41.10 10.06 278 668719 17949 79057442
Hyperuricaemia 41.08 10.06 202 668795 11597 79063794
Peripheral arterial occlusive disease 40.73 10.06 157 668840 8101 79067290
Palmar-plantar erythrodysaesthesia syndrome 40.53 10.06 441 668556 32693 79042698
Graft versus host disease 40.15 10.06 40 668957 14986 79060405
Caesarean section 40.11 10.06 28 668969 12507 79062884
Faeces discoloured 39.56 10.06 396 668601 28731 79046660
Cytomegalovirus infection reactivation 39.44 10.06 12 668985 8704 79066687
Aphasia 39.23 10.06 580 668417 46152 79029239
Breast cancer stage I 39.11 10.06 5 668992 6695 79068696
Presyncope 39.08 10.06 521 668476 40533 79034858
Multiple sclerosis relapse 38.72 10.06 230 668767 46303 79029088
Ischaemic stroke 38.71 10.06 437 668560 32694 79042697
Drug hypersensitivity 38.69 10.06 2081 666916 296835 78778556
Diabetic nephropathy 38.67 10.06 80 668917 2867 79072524
Thalamus haemorrhage 38.33 10.06 60 668937 1722 79073669
Diastolic dysfunction 38.29 10.06 186 668811 10625 79064766
Cardiomegaly 38.10 10.06 363 668634 25989 79049402
Upper respiratory tract infection 37.96 10.06 537 668460 90631 78984760
Hypoinsulinaemia 37.89 10.06 10 668987 0 79075391
Mydriasis 37.59 10.06 56 668941 17587 79057804
Psychotic disorder 37.51 10.06 199 668798 41203 79034188
Hyperaldosteronism 37.45 10.06 31 668966 429 79074962
Cognitive disorder 37.36 10.06 808 668189 69118 79006273
Loss of personal independence in daily activities 37.33 10.06 620 668377 101960 78973431
Drug use disorder 37.22 10.06 13 668984 8638 79066753
Osteoarthritis 37.16 10.06 512 668485 86797 78988594
Congenital hiatus hernia 37.13 10.06 40 668957 784 79074607
Hypervolaemia 37.08 10.06 533 668464 42157 79033234
Ovarian cyst 37.01 10.06 31 668966 12624 79062767
Progressive multifocal leukoencephalopathy 36.92 10.06 73 668924 20527 79054864
Gout 36.82 10.06 343 668654 24406 79050985
Gastric ulcer haemorrhage 36.17 10.06 161 668836 8866 79066525
Breast cancer female 36.15 10.06 26 668971 11435 79063956
Atrioventricular block second degree 36.05 10.06 139 668858 7173 79068218
Urine output decreased 36.05 10.06 267 668730 17755 79057636
Haematochezia 36.02 10.06 977 668020 86668 78988723
Type 2 diabetes mellitus 35.98 10.06 306 668691 56816 79018575
Chest pain 35.95 10.06 2792 666205 279512 78795879
Bundle branch block right 35.93 10.06 188 668809 11063 79064328
Primary hyperaldosteronism 35.84 10.06 20 668977 136 79075255
Metastatic renal cell carcinoma 35.81 10.06 68 668929 2287 79073104
Substance abuse 35.73 10.06 22 668975 10504 79064887
Acute coronary syndrome 35.63 10.06 301 668696 20832 79054559
Irritability 35.50 10.06 201 668796 40943 79034448
Drug withdrawal syndrome 35.43 10.06 160 668837 34558 79040833
Chronic graft versus host disease 35.22 10.06 7 668990 6774 79068617
Agitation 34.89 10.06 607 668390 99108 78976283
Glomerulonephritis rapidly progressive 34.77 10.06 55 668942 1593 79073798
X-ray abnormal 34.77 10.06 4 668993 5809 79069582
Bronchopulmonary aspergillosis 34.22 10.06 86 668911 22208 79053183
Unintentional medical device removal 34.21 10.06 11 668986 7701 79067690
Coeliac disease 34.20 10.06 27 668970 11324 79064067
Acute myeloid leukaemia 34.18 10.06 138 668859 30747 79044644
Arrhythmia 34.03 10.06 712 668285 60560 79014831
Device issue 34.01 10.06 115 668882 26993 79048398
Ischaemia 33.86 10.06 146 668851 7929 79067462
Neurotoxicity 33.70 10.06 149 668848 32369 79043022
Heart rate decreased 33.66 10.06 800 668197 69516 79005875
Blood lactic acid increased 33.44 10.06 202 668795 12542 79062849
Peripheral venous disease 33.41 10.06 51 668946 15858 79059533
Pulse abnormal 33.37 10.06 82 668915 3302 79072089
Vasodilatation 33.26 10.06 79 668918 3112 79072279
Affect lability 33.16 10.06 184 668813 11075 79064316
Foetal death 33.08 10.06 13 668984 8031 79067360
Red blood cell sedimentation rate 32.86 10.06 4 668993 5561 79069830
Duodenal ulcer haemorrhage 32.76 10.06 133 668864 7030 79068361
Dystonia 32.50 10.06 83 668914 21316 79054075
Putamen haemorrhage 32.36 10.06 30 668967 487 79074904
Pulmonary renal syndrome 32.29 10.06 33 668964 607 79074784
Immune-mediated myositis 32.08 10.06 82 668915 3385 79072006
Nephrosclerosis 31.82 10.06 56 668941 1774 79073617
Urinary retention 31.76 10.06 659 668338 55971 79019420
Uterine perforation 31.73 10.06 7 668990 6296 79069095
Allergic reaction to excipient 31.36 10.06 25 668972 327 79075064
Diabetic neuropathy 31.33 10.06 119 668878 6097 79069294
Malaise 31.12 10.06 4624 664373 485245 78590146
Injection site urticaria 31.11 10.06 37 668960 12789 79062602
Generalised oedema 31.08 10.06 320 668677 23389 79052002
Device difficult to use 31.01 10.06 40 668957 13345 79062046
Linear IgA disease 31.00 10.06 76 668921 3056 79072335
Blood mercury abnormal 30.73 10.06 21 668976 213 79075178
Inappropriate antidiuretic hormone secretion 30.71 10.06 347 668650 25966 79049425
Premature labour 30.69 10.06 16 668981 8374 79067017
Ischaemic cardiomyopathy 30.65 10.06 137 668860 7558 79067833
Supraventricular extrasystoles 30.59 10.06 128 668869 6859 79068532
Incorrect route of product administration 30.48 10.06 170 668827 34759 79040632
Myocardial ischaemia 30.45 10.06 338 668659 25181 79050210
Chronic obstructive pulmonary disease 30.37 10.06 935 668062 84484 78990907
Ear pain 30.33 10.06 157 668840 32712 79042679
Hepatojugular reflux 30.16 10.06 32 668965 616 79074775
Pancytopenia 30.02 10.06 1112 667885 164633 78910758
Anaphylactic reaction 29.87 10.06 508 668489 83235 78992156
Breath sounds abnormal 29.83 10.06 233 668764 15751 79059640
Adverse drug reaction 29.83 10.06 385 668612 66007 79009384
Premature delivery 29.82 10.06 99 668898 23368 79052023
Gastrointestinal haemorrhage 29.70 10.06 1520 667477 146199 78929192
Fibromuscular dysplasia 29.63 10.06 21 668976 227 79075164
Adenovirus infection 29.60 10.06 17 668980 8430 79066961
Venoocclusive liver disease 29.58 10.06 33 668964 11738 79063653
Heavy menstrual bleeding 29.34 10.06 45 668952 13966 79061425
Wound infection 29.27 10.06 103 668894 23888 79051503
Red blood cell sedimentation rate increased 28.98 10.06 246 668751 45696 79029695
Coordination abnormal 28.88 10.06 246 668751 17066 79058325
Gastrointestinal toxicity 28.87 10.06 16 668981 8093 79067298
Blood aldosterone increased 28.86 10.06 20 668977 208 79075183
Drug tolerance decreased 28.83 10.06 40 668957 12938 79062453
Sinus arrest 28.81 10.06 81 668916 3541 79071850
Forced vital capacity decreased 28.60 10.06 52 668945 1691 79073700
Yellow skin 28.48 10.06 79 668918 3426 79071965
Blood potassium increased 28.48 10.06 373 668624 28902 79046489
Constipation 28.48 10.06 2751 666246 280299 78795092
Bradyarrhythmia 28.47 10.06 88 668909 4058 79071333
Temperature regulation disorder 28.47 10.06 7 668990 5846 79069545
C-reactive protein 28.39 10.06 4 668993 4975 79070416
Drug tolerance 28.26 10.06 19 668978 8656 79066735
Gangrene 28.09 10.06 149 668848 8815 79066576
Accelerated hypertension 28.05 10.06 32 668965 670 79074721
Sensory loss 28.02 10.06 196 668801 12795 79062596
Nodule 27.87 10.06 99 668898 22895 79052496
Gingival pain 27.81 10.06 149 668848 8849 79066542
Venoocclusive disease 27.72 10.06 3 668994 4570 79070821
Fear of injection 27.71 10.06 14 668983 7460 79067931
Sickle cell anaemia with crisis 27.68 10.06 16 668981 7906 79067485
Arterial occlusive disease 27.49 10.06 142 668855 8314 79067077
Staphylococcal infection 27.33 10.06 335 668662 57960 79017431
Brain stem infarction 27.06 10.06 55 668942 1946 79073445
Mucormycosis 26.99 10.06 19 668978 8450 79066941
Gingivitis 26.95 10.06 148 668849 8873 79066518
Sinus node dysfunction 26.92 10.06 132 668865 7569 79067822
Fatigue 26.86 10.06 7165 661832 922562 78152829
Prostatic specific antigen increased 26.86 10.06 164 668833 10222 79065169
Micturition urgency 26.85 10.06 190 668807 12451 79062940
Hypertensive encephalopathy 26.82 10.06 37 668960 945 79074446
Device use error 26.79 10.06 13 668984 7088 79068303
Blood glucose decreased 26.68 10.06 337 668660 25897 79049494
Joint effusion 26.49 10.06 71 668926 17943 79057448
Lymphocyte count decreased 26.45 10.06 261 668736 47028 79028363
Stenosis 26.38 10.06 61 668936 2361 79073030
Graft versus host disease in skin 26.35 10.06 9 668988 6064 79069327
Skin toxicity 26.04 10.06 19 668978 8295 79067096
Subdural haematoma 25.94 10.06 389 668608 31045 79044346
Bladder irritation 25.70 10.06 20 668977 252 79075139
Prescription drug used without a prescription 25.58 10.06 84 668913 4001 79071390
Dialysis 25.55 10.06 252 668745 18210 79057181
Lymphadenopathy 25.34 10.06 305 668692 52942 79022449
Retinitis 25.12 10.06 8 668989 5635 79069756
Protein urine present 25.10 10.06 158 668839 9954 79065437
Prerenal failure 24.94 10.06 78 668919 3620 79071771
Schizophrenia 24.93 10.06 58 668939 15382 79060009
Cardiovascular disorder 24.93 10.06 246 668751 17779 79057612
Diffuse large B-cell lymphoma recurrent 24.90 10.06 3 668994 4204 79071187
Lymphocele 24.90 10.06 48 668949 1633 79073758
Candida infection 24.84 10.06 203 668794 38011 79037380
Sedation 24.71 10.06 590 668407 51305 79024086
Dyspnoea at rest 24.70 10.06 124 668873 7178 79068213
Sciatica 24.68 10.06 170 668827 33052 79042339
Acidosis 24.62 10.06 264 668733 19498 79055893
Muscle necrosis 24.56 10.06 44 668953 1414 79073977
Bundle branch block left 24.43 10.06 173 668824 11340 79064051
Ventricular hypertrophy 24.31 10.06 119 668878 6819 79068572
Pericardial effusion 24.29 10.06 533 668464 45704 79029687
Diabetes mellitus 24.24 10.06 844 668153 77546 78997845
Peripheral artery occlusion 24.20 10.06 61 668936 2496 79072895
Glomerulonephritis acute 24.15 10.06 20 668977 277 79075114
Clear cell renal cell carcinoma 23.91 10.06 61 668936 2515 79072876
Maternal exposure before pregnancy 23.82 10.06 4 668993 4369 79071022
Hepatic neoplasm 23.79 10.06 73 668924 3353 79072038
Appendicolith 23.74 10.06 22 668975 8529 79066862
Lower limb fracture 23.68 10.06 107 668890 23108 79052283
Lethargy 23.60 10.06 869 668128 80423 78994968
Blood pressure abnormal 23.59 10.06 234 668763 16935 79058456
Mean arterial pressure decreased 23.59 10.06 22 668975 360 79075031
Fungal infection 23.53 10.06 230 668767 41518 79033873
Finger deformity 23.52 10.06 17 668980 7457 79067934
Ageusia 23.50 10.06 228 668769 16404 79058987
Epstein-Barr virus infection 23.40 10.06 54 668943 14362 79061029
Oedema 23.33 10.06 1227 667770 118353 78957038
C-reactive protein increased 23.28 10.06 866 668131 128161 78947230
Medication error 23.25 10.06 747 668250 67895 79007496
Human herpesvirus 6 infection 23.23 10.06 8 668989 5362 79070029
Sinoatrial block 23.05 10.06 41 668956 1310 79074081
Orbital myositis 23.04 10.06 16 668981 167 79075224
Multiple drug therapy 23.03 10.06 81 668916 3997 79071394
Deformity 22.98 10.06 28 668969 9577 79065814
Hypoperfusion 22.97 10.06 61 668936 2578 79072813
Diverticulum intestinal haemorrhagic 22.93 10.06 80 668917 3931 79071460
Intestinal ischaemia 22.90 10.06 190 668807 13080 79062311
Status epilepticus 22.89 10.06 120 668877 24921 79050470
Oesophageal carcinoma 22.83 10.06 36 668961 11048 79064343
Unintended pregnancy 22.80 10.06 3 668994 3930 79071461
Lymphocyte stimulation test positive 22.79 10.06 37 668960 1096 79074295
Peripheral artery stenosis 22.64 10.06 40 668957 1271 79074120
Plasmapheresis 22.62 10.06 28 668969 641 79074750
Febrile bone marrow aplasia 22.60 10.06 47 668950 12973 79062418
Viral infection 22.59 10.06 241 668756 42775 79032616
Upper gastrointestinal haemorrhage 22.38 10.06 479 668518 40901 79034490
Femoral neck fracture 22.35 10.06 152 668845 9832 79065559
Diabetic retinopathy 22.33 10.06 67 668930 3039 79072352
Motor dysfunction 22.33 10.06 205 668792 14528 79060863
Electrocardiogram Q wave abnormal 22.32 10.06 27 668970 603 79074788
Dry eye 22.30 10.06 200 668797 36731 79038660
Renal transplant 22.29 10.06 59 668938 2488 79072903
Hypothermia 22.21 10.06 290 668707 22456 79052935
Serotonin syndrome 22.16 10.06 256 668741 44771 79030620
Alanine aminotransferase abnormal 22.13 10.06 25 668972 8842 79066549
Joint destruction 22.12 10.06 11 668986 5914 79069477
Low density lipoprotein decreased 22.06 10.06 38 668959 1183 79074208
Cerebellar haemorrhage 21.96 10.06 64 668933 2856 79072535
Thirst 21.94 10.06 246 668751 18373 79057018
Labile hypertension 21.90 10.06 25 668972 524 79074867
Blood uric acid increased 21.84 10.06 189 668808 13171 79062220
Kidney transplant rejection 21.76 10.06 154 668843 10092 79065299
Tricuspid valve incompetence 21.69 10.06 257 668740 19455 79055936
Contusion 21.69 10.06 1023 667974 147753 78927638
Rib deformity 21.66 10.06 17 668980 217 79075174
Myelodysplastic syndrome 21.55 10.06 157 668840 30144 79045247
Dyslalia 21.55 10.06 35 668962 1037 79074354
Intestinal villi atrophy 21.55 10.06 23 668974 446 79074945
Neovascularisation 21.52 10.06 38 668959 1207 79074184
Injection site haemorrhage 21.51 10.06 141 668856 27729 79047662
Hypersensitivity vasculitis 21.48 10.06 115 668882 6828 79068563
Large intestine polyp 21.42 10.06 181 668816 12527 79062864
Uveitis 21.39 10.06 71 668926 16759 79058632
Haemoglobin decreased 21.34 10.06 2152 666845 219967 78855424
Tendonitis 21.33 10.06 115 668882 23715 79051676
Abortion induced 21.30 10.06 17 668980 7092 79068299
Aplastic anaemia 21.29 10.06 237 668760 17668 79057723
Scleral discolouration 21.28 10.06 26 668971 587 79074804
Myopathy 21.28 10.06 265 668732 20298 79055093
Device dislocation 21.27 10.06 129 668868 25841 79049550
Sepsis 21.25 10.06 1958 667039 267470 78807921
Metastases to bone 21.25 10.06 119 668878 24308 79051083
Aortic stenosis 21.09 10.06 121 668876 7374 79068017
Urine albumin/creatinine ratio increased 21.03 10.06 25 668972 548 79074843
Chromaturia 21.01 10.06 318 668679 25428 79049963
Blood cholinesterase decreased 20.95 10.06 18 668979 263 79075128
Joint stiffness 20.94 10.06 230 668767 40600 79034791
Night sweats 20.93 10.06 309 668688 51786 79023605
Enthesopathy 20.92 10.06 41 668956 11567 79063824
Traumatic haemorrhage 20.90 10.06 39 668958 1294 79074097
Cardiac dysfunction 20.83 10.06 79 668918 4045 79071346
Purpura 20.79 10.06 253 668744 19274 79056117
CD30 expression 20.72 10.06 10 668987 48 79075343
Vertigo 20.67 10.06 741 668256 68341 79007050
Obsessive-compulsive disorder 20.67 10.06 12 668985 5915 79069476
Dilatation ventricular 20.61 10.06 79 668918 4065 79071326
Headache 20.61 10.06 5018 663979 648754 78426637
Seizure 20.59 10.06 1336 667661 187498 78887893
Body tinea 20.53 10.06 47 668950 1807 79073584
Glucose tolerance impaired 20.50 10.06 127 668870 7957 79067434
Bundle branch block 20.49 10.06 43 668954 1557 79073834
Ocular icterus 20.48 10.06 96 668901 5404 79069987
Synovial cyst 20.44 10.06 33 668964 10032 79065359
Nipple inflammation 20.39 10.06 10 668987 50 79075341
Hyperplasia 20.29 10.06 37 668960 1206 79074185
Skin tightness 20.28 10.06 96 668901 5426 79069965
Product dose omission issue 20.23 10.06 1794 667203 245743 78829648
Left ventricular enlargement 20.21 10.06 28 668969 718 79074673
Pleural effusion 20.04 10.06 1446 667551 143816 78931575
Cytomegalovirus viraemia 20.04 10.06 49 668948 12772 79062619
Colon cancer 19.99 10.06 198 668799 14325 79061066
Alcohol abuse 19.95 10.06 10 668987 5353 79070038
Carcinoid tumour 19.94 10.06 24 668973 533 79074858
Fibrillary glomerulonephritis 19.93 10.06 10 668987 53 79075338
Nephrogenic anaemia 19.92 10.06 75 668922 3827 79071564
Left atrial enlargement 19.88 10.06 36 668961 1167 79074224
Normal newborn 19.86 10.06 18 668979 7054 79068337
Polypectomy 19.85 10.06 36 668961 1168 79074223
Foetal exposure during pregnancy 19.80 10.06 12 668985 5778 79069613
Procedural pain 19.79 10.06 113 668884 22971 79052420
Azotaemia 19.73 10.06 128 668869 8148 79067243
Nephrogenic systemic fibrosis 19.72 10.06 103 668894 6057 79069334
Ballismus 19.62 10.06 18 668979 288 79075103
Liver carcinoma ruptured 19.60 10.06 15 668982 184 79075207
Pulmonary valve disease 19.52 10.06 18 668979 290 79075101
Injection site rash 19.38 10.06 81 668916 17873 79057518
Graft versus host disease in gastrointestinal tract 19.30 10.06 15 668982 6341 79069050
Hypertonic bladder 19.21 10.06 78 668919 4123 79071268
Hypovolaemic shock 19.21 10.06 172 668825 12104 79063287
Mucosal membrane hyperplasia 19.19 10.06 9 668988 40 79075351
Hypergastrinaemia 19.14 10.06 15 668982 191 79075200
Zoonotic bacterial infection 19.07 10.06 10 668987 59 79075332
Benign neoplasm of adrenal gland 19.01 10.06 9 668988 41 79075350
Device leakage 19 10.06 39 668958 10817 79064574
Enterochromaffin cell hyperplasia 19.00 10.06 11 668986 81 79075310
Haemorrhage subepidermal 18.95 10.06 7 668990 14 79075377
Blood loss anaemia 18.83 10.06 206 668791 15292 79060099
COVID-19 18.68 10.06 1107 667890 156567 78918824
Blood sodium decreased 18.65 10.06 387 668610 32868 79042523
Chondroma 18.63 10.06 6 668991 6 79075385
Lecithin-cholesterol acyltransferase deficiency 18.63 10.06 6 668991 6 79075385
Multiple sclerosis 18.61 10.06 110 668887 22172 79053219
Flushing 18.58 10.06 581 668416 87687 78987704
Herpes zoster 18.57 10.06 617 668380 92466 78982925
Varicella zoster virus infection 18.55 10.06 7 668990 4434 79070957
Osteopenia 18.52 10.06 85 668912 18279 79057112
Lichen nitidus 18.46 10.06 11 668986 86 79075305
Dysgeusia 18.28 10.06 618 668379 56559 79018832
Electrocardiogram P wave abnormal 18.27 10.06 19 668978 357 79075034
Female genital tract fistula 18.27 10.06 14 668983 5961 79069430
Type I hypersensitivity 18.26 10.06 7 668990 4391 79071000
Prostate cancer recurrent 18.24 10.06 28 668969 790 79074601
Eczema 18.21 10.06 460 668537 40358 79035033
Dyskinesia 18.18 10.06 265 668732 44508 79030883
Systemic infection 18.11 10.06 142 668855 9610 79065781
Cerebral ischaemia 18.11 10.06 158 668839 11037 79064354
Mycobacterium marinum infection 18.10 10.06 21 668976 448 79074943
Epiglottic oedema 18.10 10.06 18 668979 320 79075071
Toxic skin eruption 18.05 10.06 275 668722 22018 79053373
Ventricular hyperkinesia 18.04 10.06 17 668980 282 79075109
Sleep disorder 18.03 10.06 564 668433 85113 78990278
Aortic aneurysm 17.97 10.06 127 668870 8319 79067072
Product tampering 17.94 10.06 20 668977 408 79074983
Cardiac disorder 17.91 10.06 698 668299 65059 79010332
Carotid sinus syndrome 17.88 10.06 14 668983 178 79075213
Renal injury 17.88 10.06 219 668778 16708 79058683
Hyperparathyroidism secondary 17.84 10.06 56 668941 2604 79072787
Portal hypertension 17.78 10.06 20 668977 7088 79068303
Lipodystrophy acquired 17.77 10.06 7 668990 4318 79071073
Atrioventricular dissociation 17.75 10.06 18 668979 328 79075063
Polymyositis 17.75 10.06 61 668936 2975 79072416
Gingival disorder 17.67 10.06 69 668928 3582 79071809
Gallbladder adenocarcinoma 17.62 10.06 12 668985 121 79075270
Bladder sphincter atony 17.62 10.06 12 668985 121 79075270
Pulmonary hypoplasia 17.60 10.06 9 668988 50 79075341
End stage renal disease 17.50 10.06 168 668829 12052 79063339
Gamma-glutamyltransferase increased 17.48 10.06 591 668406 54089 79021302
Duodenal ulcer 17.39 10.06 212 668785 16157 79059234
Pericardial disease 17.37 10.06 23 668974 564 79074827
Dysphonia 17.25 10.06 611 668386 56261 79019130
Herpes simplex 17.20 10.06 49 668948 12138 79063253
Electrolyte imbalance 17.19 10.06 359 668638 30522 79044869
Sexual dysfunction 17.17 10.06 24 668973 7739 79067652
Drug level increased 17.15 10.06 445 668552 39206 79036185
Fine motor skill dysfunction 17.10 10.06 12 668985 5345 79070046
Cardiac arrest 17.05 10.06 1671 667326 170425 78904966
Hypoglossal nerve paralysis 17.00 10.06 7 668990 21 79075370
Cholecystitis chronic 16.99 10.06 36 668961 9870 79065521
Labelled drug-drug interaction medication error 16.91 10.06 326 668671 27324 79048067
Fulminant type 1 diabetes mellitus 16.87 10.06 38 668959 1445 79073946
Virologic failure 16.86 10.06 7 668990 4184 79071207
Complication of device insertion 16.86 10.06 17 668980 6333 79069058
Retinopathy hypertensive 16.79 10.06 21 668976 486 79074905
Orthopnoea 16.73 10.06 143 668854 9930 79065461
Nasal crusting 16.71 10.06 23 668974 586 79074805
Cardiac failure acute 16.70 10.06 237 668760 18692 79056699
Cytomegalovirus chorioretinitis 16.61 10.06 13 668984 5477 79069914
Angiopathy 16.56 10.06 109 668888 6973 79068418
Intraventricular haemorrhage 16.54 10.06 83 668914 4804 79070587
Pleuritic pain 16.50 10.06 38 668959 10114 79065277
Hyperthyroidism 16.49 10.06 270 668727 21939 79053452
Cystic fibrosis 16.41 10.06 6 668991 3874 79071517
Neoplasm progression 16.39 10.06 320 668677 51362 79024029
Injection site discolouration 16.38 10.06 24 668973 7590 79067801
Cough 16.36 10.06 3399 665598 363390 78712001
Renal function test abnormal 16.30 10.06 84 668913 4914 79070477
Suspected suicide attempt 16.28 10.06 17 668980 321 79075070
Vascular device infection 16.28 10.06 39 668958 10237 79065154
Harlequin syndrome 16.27 10.06 9 668988 60 79075331
Embolic stroke 16.26 10.06 117 668880 7709 79067682
Needle fatigue 16.20 10.06 28 668969 874 79074517
Appendicitis 16.15 10.06 105 668892 20689 79054702
Coronary artery stenosis 16.13 10.06 168 668829 12316 79063075
Ultrasound uterus abnormal 16.10 10.06 7 668990 25 79075366
Drug abuser 16.07 10.06 16 668981 5997 79069394
Vasculitis 16.06 10.06 298 668699 24804 79050587
Tricuspid valve calcification 16.04 10.06 5 668992 4 79075387
Disturbance in social behaviour 16.04 10.06 11 668986 4959 79070432
Atheroembolism 16.03 10.06 17 668980 327 79075064
Band neutrophil percentage decreased 15.93 10.06 6 668991 13 79075378
Essential hypertension 15.92 10.06 96 668901 5957 79069434
Rales 15.92 10.06 246 668751 19755 79055636
Helicobacter gastritis 15.92 10.06 51 668946 2398 79072993
Acute pulmonary oedema 15.86 10.06 186 668811 14044 79061347
Femoral artery dissection 15.86 10.06 8 668989 43 79075348
Panniculitis 15.85 10.06 52 668945 12319 79063072
Accidental exposure to product 15.84 10.06 177 668820 31145 79044246
Benign prostatic hyperplasia 15.83 10.06 158 668839 11454 79063937
Cutaneous vasculitis 15.79 10.06 121 668876 8131 79067260
Blood parathyroid hormone increased 15.78 10.06 64 668933 3381 79072010
Colitis ulcerative 15.78 10.06 201 668796 34541 79040850
Sensitivity to weather change 15.77 10.06 27 668970 8020 79067371
Eyelid oedema 15.75 10.06 180 668817 13507 79061884
Glucose urine present 15.70 10.06 41 668956 1715 79073676
Obstructive airways disorder 15.69 10.06 360 668637 31099 79044292
Coronary artery occlusion 15.69 10.06 197 668800 15118 79060273
Acute graft versus host disease in skin 15.65 10.06 25 668972 7633 79067758
Cryopyrin associated periodic syndrome 15.63 10.06 18 668979 381 79075010
Hyperthermia 15.62 10.06 88 668909 17949 79057442
Listless 15.57 10.06 69 668928 3792 79071599
Hyperprolactinaemia 15.56 10.06 10 668987 4666 79070725
Fistula 15.49 10.06 56 668941 12884 79062507
Suicidal ideation 15.47 10.06 505 668492 75835 78999556
Extrasystoles 15.46 10.06 111 668886 7308 79068083
Noninfective gingivitis 15.46 10.06 39 668958 1597 79073794
Coma scale abnormal 15.38 10.06 125 668872 8553 79066838
Intestinal angioedema 15.33 10.06 27 668970 856 79074535
Hepatosplenomegaly 15.27 10.06 17 668980 6052 79069339
Product storage error 15.26 10.06 77 668920 16149 79059242
Hypertensive urgency 15.20 10.06 21 668976 537 79074854
Ventricular extrasystoles 15.17 10.06 241 668756 19463 79055928
Idiopathic pulmonary fibrosis 15.16 10.06 73 668924 4155 79071236
Ventricular compliance decreased 15.16 10.06 4 668993 0 79075391
Aortic valve incompetence 15.16 10.06 134 668863 9396 79065995
Cardiorenal syndrome 15.14 10.06 38 668959 1551 79073840
Klebsiella infection 15.12 10.06 74 668923 15646 79059745
Tongue disorder 15.11 10.06 63 668934 13912 79061479
Hypertensive nephropathy 15.07 10.06 29 668968 985 79074406
Craniectomy 15.05 10.06 5 668992 6 79075385
Hypovolaemia 15.01 10.06 220 668777 17471 79057920
Nephropathy 15.01 10.06 136 668861 9602 79065789
Inappropriate schedule of product administration 14.98 10.06 943 668054 132685 78942706
Pericardial haemorrhage 14.97 10.06 76 668921 4419 79070972
Claustrophobia 14.96 10.06 33 668964 1237 79074154
Jaundice 14.93 10.06 568 668429 52781 79022610
Food allergy 14.93 10.06 44 668953 10780 79064611
Walking aid user 14.92 10.06 40 668957 10108 79065283
Gastric pH increased 14.89 10.06 8 668989 50 79075341
Galactorrhoea 14.82 10.06 6 668991 3640 79071751
Arthritis 14.80 10.06 800 668197 114080 78961311
Hepatitis 14.79 10.06 355 668642 55372 79020019
Rectal ulcer haemorrhage 14.76 10.06 15 668982 274 79075117
Sinonasal obstruction 14.76 10.06 16 668981 316 79075075
Adenoma benign 14.69 10.06 31 668966 1127 79074264
Wrong patient received product 14.63 10.06 77 668920 4541 79070850
Pelvic cyst 14.63 10.06 8 668989 52 79075339
Inhibitory drug interaction 14.63 10.06 75 668922 4378 79071013
Sex hormone binding globulin increased 14.63 10.06 5 668992 7 79075384
Mitochondrial toxicity 14.62 10.06 4 668993 3110 79072281
Encephalitis toxic 14.59 10.06 15 668982 278 79075113
Road traffic accident 14.57 10.06 268 668729 43396 79031995
Premature rupture of membranes 14.53 10.06 8 668989 4061 79071330
Faecal calprotectin increased 14.52 10.06 15 668982 5526 79069865
Pharyngitis streptococcal 14.45 10.06 44 668953 10670 79064721
Haemorrhagic diathesis 14.45 10.06 94 668903 5990 79069401
Hypertensive cardiomyopathy 14.44 10.06 16 668981 324 79075067
Base excess decreased 14.43 10.06 17 668980 369 79075022
Haemorrhage intracranial 14.42 10.06 304 668693 25889 79049502
Haematuria 14.38 10.06 711 668286 68125 79007266
Neuropathy peripheral 14.35 10.06 1006 667991 140299 78935092
Enterococcal infection 14.34 10.06 75 668922 15585 79059806
Macroglossia 14.27 10.06 31 668966 1150 79074241
Intercepted product preparation error 14.24 10.06 6 668991 3554 79071837
Rheumatoid lung 14.23 10.06 9 668988 4236 79071155
Genital haemorrhage 14.17 10.06 19 668978 6236 79069155
Transplant rejection 14.17 10.06 100 668897 19337 79056054
Giant cell arteritis 14.14 10.06 53 668944 2698 79072693
Blood cholinesterase increased 14.12 10.06 7 668990 36 79075355
Coronary arterial stent insertion 14.12 10.06 93 668904 5951 79069440
Cell marker increased 14.12 10.06 22 668975 629 79074762
Anal fissure 14.06 10.06 27 668970 7676 79067715
Skin candida 14.06 10.06 44 668953 2043 79073348
Lip oedema 14.04 10.06 96 668901 6220 79069171
Continuous haemodiafiltration 14.04 10.06 43 668954 1973 79073418
Drug level below therapeutic 14.00 10.06 39 668958 9731 79065660
Blood urea abnormal 13.99 10.06 33 668964 1294 79074097
Vascular resistance systemic decreased 13.97 10.06 13 668984 212 79075179
Malpositioned teeth 13.97 10.06 7 668990 37 79075354
Eosinophilia 13.96 10.06 488 668509 44857 79030534
Physical examination abnormal 13.93 10.06 15 668982 294 79075097
Poor venous access 13.91 10.06 92 668905 18057 79057334
Generalised tonic-clonic seizure 13.88 10.06 272 668725 43638 79031753
Tenderness 13.85 10.06 129 668868 23513 79051878
Myositis 13.85 10.06 232 668765 18936 79056455
Full blood count abnormal 13.85 10.06 441 668556 40033 79035358
Cold sweat 13.76 10.06 227 668770 18472 79056919
Cross sensitivity reaction 13.69 10.06 7 668990 3705 79071686
Cellulitis of male external genital organ 13.67 10.06 7 668990 39 79075352
Metabolic disorder 13.59 10.06 36 668961 9134 79066257
Device breakage 13.59 10.06 45 668952 10630 79064761
Lung hernia 13.59 10.06 8 668989 61 79075330
Drug eruption 13.57 10.06 473 668524 43462 79031929
Coronary artery surgery 13.55 10.06 12 668985 183 79075208
Herbal interaction 13.55 10.06 19 668978 493 79074898
IgA nephropathy 13.54 10.06 39 668958 1729 79073662
Device deployment issue 13.53 10.06 5 668992 3207 79072184
Peritoneal dialysis complication 13.50 10.06 47 668950 2307 79073084
Product administered to patient of inappropriate age 13.49 10.06 16 668981 5537 79069854
Product solubility abnormal 13.48 10.06 27 668970 945 79074446
Sodium retention 13.44 10.06 12 668985 185 79075206
Bone cyst 13.39 10.06 6 668991 3427 79071964
Electrocardiogram abnormal 13.37 10.06 206 668791 16531 79058860
Brain abscess 13.35 10.06 13 668984 4923 79070468
Carcinoid tumour of the stomach 13.34 10.06 12 668985 187 79075204
Microalbuminuria 13.34 10.06 26 668971 892 79074499
Sinus rhythm 13.33 10.06 25 668972 833 79074558
Analgesic drug level increased 13.29 10.06 5 668992 3173 79072218
Hydronephrosis 13.26 10.06 213 668784 17241 79058150
Disorientation 13.24 10.06 649 668348 62127 79013264
Vaginal haemorrhage 13.24 10.06 118 668879 21699 79053692
Device related infection 13.23 10.06 205 668792 34089 79041302
Iliac artery occlusion 13.23 10.06 15 668982 312 79075079
Intermenstrual bleeding 13.20 10.06 18 668979 5866 79069525
Tardive dyskinesia 13.16 10.06 45 668952 10526 79064865
Drug screen positive 13.16 10.06 19 668978 6044 79069347
Intentional product misuse 13.15 10.06 658 668339 94507 78980884
Electrocardiogram T wave amplitude decreased 13.11 10.06 23 668974 727 79074664
Gait inability 13.09 10.06 385 668612 58532 79016859
Hallucination, gustatory 13.07 10.06 8 668989 66 79075325
Musculoskeletal disorder 13.01 10.06 116 668881 21332 79054059
Head injury 13.00 10.06 408 668589 36961 79038430
Liver function test increased 13.00 10.06 245 668752 39528 79035863
Acute motor-sensory axonal neuropathy 12.99 10.06 17 668980 412 79074979
Osteonecrosis 12.99 10.06 183 668814 30912 79044479
Metabolic alkalosis 12.98 10.06 73 668924 4416 79070975
Exposure via ingestion 12.94 10.06 81 668916 5093 79070298
Pericarditis uraemic 12.93 10.06 5 668992 12 79075379
Vision blurred 12.91 10.06 1044 667953 104854 78970537
Vasculitic rash 12.87 10.06 44 668953 2140 79073251
Toxic nodular goitre 12.87 10.06 7 668990 45 79075346
Streptococcal infection 12.84 10.06 35 668962 8795 79066596
Loose tooth 12.80 10.06 56 668941 3061 79072330
Drug dispensed to wrong patient 12.79 10.06 22 668975 684 79074707
Adulterated product 12.77 10.06 14 668983 280 79075111
Paranoia 12.73 10.06 103 668894 19329 79056062
Chronic sinusitis 12.72 10.06 61 668936 12965 79062426
Tuberculosis 12.71 10.06 75 668922 15123 79060268
Brain oedema 12.68 10.06 143 668854 25120 79050271
Ulcer 12.66 10.06 176 668821 29796 79045595
Neuroendocrine tumour 12.66 10.06 32 668965 1312 79074079
Kidney fibrosis 12.65 10.06 61 668936 3474 79071917
Cardiac failure chronic 12.61 10.06 146 668851 10989 79064402
Dermatomyositis 12.59 10.06 62 668935 3561 79071830
Anosognosia 12.59 10.06 8 668989 3756 79071635
Nipple disorder 12.59 10.06 12 668985 202 79075189
Hypertensive angiopathy 12.57 10.06 9 668988 99 79075292
Periarticular disorder 12.56 10.06 6 668991 28 79075363
Cardiac myxoma 12.53 10.06 10 668987 131 79075260
Dermatosis 12.53 10.06 20 668977 584 79074807
Muscle twitching 12.50 10.06 140 668857 24624 79050767
Phaeochromocytoma malignant 12.50 10.06 8 668989 72 79075319
Apathy 12.48 10.06 165 668832 12812 79062579
Flatulence 12.47 10.06 457 668540 42267 79033124
Nail disorder 12.47 10.06 54 668943 11798 79063593
Hypogammaglobulinaemia 12.44 10.06 61 668936 12890 79062501
Gestational diabetes 12.44 10.06 21 668976 6272 79069119
Venous aneurysm 12.42 10.06 4 668993 4 79075387
Product label on wrong product 12.40 10.06 6 668991 29 79075362
Dermatitis infected 12.39 10.06 14 668983 290 79075101
Venous oxygen saturation decreased 12.39 10.06 5 668992 14 79075377
Blood parathyroid hormone decreased 12.35 10.06 46 668951 10490 79064901
Mouth swelling 12.30 10.06 90 668907 5961 79069430
Beta 2 microglobulin urine increased 12.28 10.06 10 668987 135 79075256
Brain stem haemorrhage 12.25 10.06 36 668961 1614 79073777
Carbohydrate metabolism disorder 12.24 10.06 6 668991 30 79075361
Guillain-Barre syndrome 12.23 10.06 122 668875 8843 79066548
Leukaemoid reaction 12.20 10.06 15 668982 341 79075050
Tachyarrhythmia 12.18 10.06 100 668897 6862 79068529
Adrenal neoplasm 12.17 10.06 18 668979 491 79074900
Diarrhoea 12.15 10.06 7812 661185 872677 78202714
Monoparesis 12.15 10.06 60 668937 3451 79071940
Stent placement 12.14 10.06 95 668902 6425 79068966
Pelvi-ureteric obstruction 12.14 10.06 8 668989 76 79075315
Atrial natriuretic peptide increased 12.14 10.06 5 668992 15 79075376
Gingival atrophy 12.14 10.06 8 668989 76 79075315
Lung diffusion test decreased 12.14 10.06 31 668966 1279 79074112
Anal fistula 12.11 10.06 25 668972 6919 79068472
Skin weeping 12.10 10.06 27 668970 1020 79074371
Peripheral ischaemia 12.09 10.06 127 668870 9330 79066061
Oral discharge 12.06 10.06 13 668984 255 79075136
Benign gastrointestinal neoplasm 12.04 10.06 10 668987 139 79075252
Autoimmune enteropathy 12.04 10.06 7 668990 52 79075339
Blood pressure systolic decreased 12.01 10.06 144 668853 10932 79064459
Pulmonary alveolar haemorrhage 12.00 10.06 148 668849 11309 79064082
Optic nerve injury 12.00 10.06 20 668977 606 79074785
Osteoma 11.99 10.06 9 668988 107 79075284
Renal artery occlusion 11.99 10.06 10 668987 140 79075251
Rhinovirus infection 11.96 10.06 31 668966 7922 79067469
Urine flow decreased 11.95 10.06 28 668969 1093 79074298
Thrombotic cerebral infarction 11.95 10.06 19 668978 553 79074838
Post-traumatic amnestic disorder 11.93 10.06 7 668990 53 79075338
Blood sodium increased 11.93 10.06 75 668922 4723 79070668
Cardiac valve sclerosis 11.92 10.06 9 668988 108 79075283
Epididymal cyst 11.91 10.06 5 668992 16 79075375
Surfactant protein increased 11.91 10.06 5 668992 16 79075375
No adverse event 11.88 10.06 230 668767 36962 79038429
Therapy interrupted 11.87 10.06 188 668809 31153 79044238
Q fever 11.86 10.06 13 668984 260 79075131
Neurosensory hypoacusis 11.86 10.06 12 668985 218 79075173
Splenic rupture 11.83 10.06 46 668951 2383 79073008
Dermatitis exfoliative 11.83 10.06 141 668856 10688 79064703
Hyperparathyroidism 11.80 10.06 56 668941 3168 79072223
Pleural mass 11.80 10.06 8 668989 80 79075311
Gait spastic 11.80 10.06 29 668968 1168 79074223
Lupus-like syndrome 11.79 10.06 68 668929 13789 79061602
Vulvovaginal burning sensation 11.74 10.06 35 668962 1582 79073809
Vagus nerve disorder 11.72 10.06 7 668990 55 79075336
Metastases to fallopian tube 11.72 10.06 7 668990 55 79075336
Menstruation irregular 11.72 10.06 15 668982 5021 79070370
Ventricular drainage 11.68 10.06 5 668992 17 79075374
Exostosis 11.68 10.06 88 668909 16770 79058621
Malignant hypertension 11.67 10.06 35 668962 1587 79073804
Orbital swelling 11.61 10.06 7 668990 56 79075335
Conjunctivitis 11.59 10.06 149 668848 25566 79049825
Neuroleptic malignant syndrome 11.58 10.06 162 668835 27397 79047994
Mobility decreased 11.57 10.06 875 668122 121300 78954091
Pleuroperitoneal communication 11.54 10.06 4 668993 6 79075385
Gingival hypoplasia 11.54 10.06 4 668993 6 79075385
Hypothyroidism 11.54 10.06 544 668453 51848 79023543
Tumour rupture 11.54 10.06 17 668980 462 79074929
Leukocytosis 11.53 10.06 460 668537 42995 79032396
Joint injury 11.52 10.06 189 668808 31146 79044245
Anal abscess 11.52 10.06 40 668957 9315 79066076
Hepatitis B reactivation 11.51 10.06 21 668976 6087 79069304
Norepinephrine increased 11.48 10.06 8 668989 84 79075307
Incorrect dose administered by device 11.46 10.06 15 668982 4974 79070417
Peripheral coldness 11.43 10.06 193 668804 15777 79059614
Neutrophil count decreased 11.42 10.06 658 668339 93301 78982090
Head discomfort 11.40 10.06 178 668819 14324 79061067
Palatal oedema 11.38 10.06 32 668965 1399 79073992
Electrocardiogram QRS complex prolonged 11.38 10.06 140 668857 10693 79064698
Glucose tolerance increased 11.37 10.06 3 668994 0 79075391
Oesophageal adenocarcinoma stage III 11.37 10.06 3 668994 0 79075391
Tear discolouration 11.37 10.06 3 668994 0 79075391
Diabetic enteropathy 11.37 10.06 3 668994 0 79075391
Protein albumin ratio decreased 11.37 10.06 3 668994 0 79075391
Secondary hypertension 11.36 10.06 15 668982 367 79075024
Interstitial granulomatous dermatitis 11.35 10.06 12 668985 230 79075161
Colorectal cancer 11.32 10.06 36 668961 8611 79066780
Renovascular hypertension 11.31 10.06 7 668990 59 79075332
Depression 11.30 10.06 1620 667377 215170 78860221
Nasal oedema 11.29 10.06 36 668961 1688 79073703
Vaginal infection 11.27 10.06 20 668977 5860 79069531
Ventricular failure 11.24 10.06 18 668979 527 79074864
Primary hypoparathyroidism 11.23 10.06 6 668991 37 79075354
Urine protein/creatinine ratio increased 11.23 10.06 29 668968 1205 79074186
Acute respiratory failure 11.22 10.06 609 668388 58932 79016459
Cerebrovascular disorder 11.21 10.06 61 668936 3644 79071747
Myasthenia gravis 11.18 10.06 135 668862 10264 79065127
Cerebral toxoplasmosis 11.15 10.06 3 668994 2359 79073032
Cerebrovascular arteriovenous malformation 11.15 10.06 9 668988 120 79075271
Immune effector cell-associated neurotoxicity syndrome 11.12 10.06 20 668977 5828 79069563
Muscular weakness 11.11 10.06 1525 667472 159204 78916187
Shock haemorrhagic 11.10 10.06 233 668764 19827 79055564
Abnormal behaviour 11.10 10.06 227 668770 36194 79039197
Tumour haemorrhage 11.07 10.06 66 668931 4078 79071313
Deafness neurosensory 11.07 10.06 26 668971 6872 79068519
Retroperitoneal oedema 11.07 10.06 5 668992 20 79075371
Flour sensitivity 11.07 10.06 5 668992 20 79075371
Tenosynovitis stenosans 11.07 10.06 6 668991 3072 79072319
Retinal ischaemia 11.06 10.06 22 668975 766 79074625
Renal artery thrombosis 11.01 10.06 17 668980 482 79074909
Lymphopenia 11.01 10.06 185 668812 30372 79045019
Hepatic failure 11.00 10.06 411 668586 60801 79014590
Crush syndrome 11.00 10.06 11 668986 197 79075194
Prostatomegaly 10.99 10.06 58 668939 3425 79071966
Thromboangiitis obliterans 10.97 10.06 6 668991 39 79075352
Ureteric cancer 10.97 10.06 13 668984 284 79075107
Peritoneal dialysis 10.95 10.06 23 668974 833 79074558
Basal ganglia stroke 10.95 10.06 10 668987 159 79075232
Abnormal loss of weight 10.95 10.06 113 668884 8263 79067128
Bone density abnormal 10.95 10.06 6 668991 3054 79072337
Cardiac pacemaker insertion 10.94 10.06 85 668912 5737 79069654
Skin exfoliation 10.87 10.06 566 668431 54534 79020857
Malignant neoplasm of renal pelvis 10.85 10.06 9 668988 125 79075266
Hyperhidrosis 10.80 10.06 1109 667888 150383 78925008
Renal mass 10.80 10.06 56 668941 3284 79072107
Anorexia nervosa 10.79 10.06 12 668985 244 79075147
Respiratory failure 10.79 10.06 1702 667295 179209 78896182
Electrocardiogram U wave present 10.79 10.06 9 668988 126 79075265
Breast cancer 10.76 10.06 209 668788 33572 79041819
Lacrimal disorder 10.76 10.06 17 668980 492 79074899
Polycystic liver disease 10.75 10.06 10 668987 163 79075228
Necrotising myositis 10.72 10.06 29 668968 1239 79074152
Leukaemic infiltration renal 10.70 10.06 5 668992 22 79075369
Biopsy kidney 10.65 10.06 10 668987 165 79075226
Affective disorder 10.64 10.06 35 668962 8284 79067107
Nausea 10.63 10.06 7623 661374 949573 78125818
Henoch-Schonlein purpura 10.61 10.06 48 668949 2662 79072729
Leukaemia recurrent 10.58 10.06 5 668992 2769 79072622
Stent malfunction 10.58 10.06 7 668990 67 79075324
Vulvovaginal pruritus 10.58 10.06 47 668950 2586 79072805
Foot operation 10.55 10.06 20 668977 5713 79069678
Hyperkaliuria 10.51 10.06 10 668987 168 79075223
Apical granuloma 10.50 10.06 6 668991 43 79075348
Splenic cyst 10.49 10.06 12 668985 252 79075139
Drug dose omission by device 10.48 10.06 23 668974 6227 79069164
Tic 10.48 10.06 6 668991 2980 79072411
Dactylitis 10.47 10.06 5 668992 2752 79072639
Acute respiratory distress syndrome 10.45 10.06 461 668536 43606 79031785
Erysipelas 10.45 10.06 138 668859 10712 79064679
Microscopic polyangiitis 10.45 10.06 15 668982 398 79074993
Occult blood 10.41 10.06 35 668962 1688 79073703
Pneumonia cytomegaloviral 10.37 10.06 16 668981 4953 79070438
Hyperplastic cholecystopathy 10.36 10.06 11 668986 212 79075179
Pneumothorax traumatic 10.35 10.06 12 668985 256 79075135
Back pain 10.34 10.06 2326 666671 301854 78773537
Chest discomfort 10.33 10.06 1316 667681 136728 78938663
Transaminases increased 10.31 10.06 343 668654 51400 79023991
Fluid intake reduced 10.30 10.06 89 668908 6199 79069192
Post procedural pneumonia 10.28 10.06 9 668988 135 79075256
Prostatic operation 10.27 10.06 12 668985 258 79075133
Hallucination, visual 10.27 10.06 353 668644 32376 79043015
Pyelonephritis acute 10.27 10.06 86 668911 5937 79069454
Blepharospasm 10.26 10.06 21 668976 5830 79069561
Acute myeloid leukaemia recurrent 10.25 10.06 8 668989 3375 79072016
Rebound effect 10.24 10.06 29 668968 7197 79068194
Brain contusion 10.24 10.06 30 668967 1343 79074048
Large cell lung cancer metastatic 10.23 10.06 4 668993 10 79075381
Bifascicular block 10.22 10.06 14 668983 355 79075036
Extremity necrosis 10.22 10.06 53 668944 3108 79072283
Lichenification 10.22 10.06 22 668975 811 79074580
Crying 10.21 10.06 134 668863 22909 79052482
Blood pressure difference of extremities 10.20 10.06 5 668992 25 79075366
Systemic candida 10.19 10.06 26 668971 6680 79068711
Metastases to central nervous system 10.18 10.06 88 668909 16287 79059104
Skin haemorrhage 10.17 10.06 149 668848 11832 79063559
Granuloma skin 10.14 10.06 41 668956 9133 79066258
Water intoxication 10.14 10.06 21 668976 753 79074638
Foaming at mouth 10.13 10.06 37 668960 1860 79073531
Product dispensing error 10.13 10.06 162 668835 13101 79062290
Laryngeal cancer 10.12 10.06 21 668976 754 79074637
Duodenal ulcer repair 10.08 10.06 7 668990 73 79075318
Mitral valve thickening 10.06 10.06 15 668982 412 79074979

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C07FB07 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS, OTHER COMBINATIONS
Beta blocking agents and calcium channel blockers
ATC C07FB12 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS, OTHER COMBINATIONS
Beta blocking agents and calcium channel blockers
ATC C07FB13 CARDIOVASCULAR SYSTEM
BETA BLOCKING AGENTS
BETA BLOCKING AGENTS, OTHER COMBINATIONS
Beta blocking agents and calcium channel blockers
ATC C08CA01 CARDIOVASCULAR SYSTEM
CALCIUM CHANNEL BLOCKERS
SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS
Dihydropyridine derivatives
ATC C08CA51 CARDIOVASCULAR SYSTEM
CALCIUM CHANNEL BLOCKERS
SELECTIVE CALCIUM CHANNEL BLOCKERS WITH MAINLY VASCULAR EFFECTS
Dihydropyridine derivatives
ATC C08GA02 CARDIOVASCULAR SYSTEM
CALCIUM CHANNEL BLOCKERS
CALCIUM CHANNEL BLOCKERS AND DIURETICS
Calcium channel blockers and diuretics
ATC C09BB03 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, COMBINATIONS
ACE inhibitors and calcium channel blockers
ATC C09BB04 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, COMBINATIONS
ACE inhibitors and calcium channel blockers
ATC C09BB07 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, COMBINATIONS
ACE inhibitors and calcium channel blockers
ATC C09BB13 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, COMBINATIONS
ACE inhibitors and calcium channel blockers
ATC C09BX01 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, COMBINATIONS
ACE inhibitors, other combinations
ATC C09BX03 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, COMBINATIONS
ACE inhibitors, other combinations
ATC C09BX04 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ACE INHIBITORS, COMBINATIONS
ACE inhibitors, other combinations
ATC C09DB01 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS
Angiotensin II receptor blockers (ARBs) and calcium channel blockers
ATC C09DB02 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS
Angiotensin II receptor blockers (ARBs) and calcium channel blockers
ATC C09DB04 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS
Angiotensin II receptor blockers (ARBs) and calcium channel blockers
ATC C09DB05 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS
Angiotensin II receptor blockers (ARBs) and calcium channel blockers
ATC C09DB06 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS
Angiotensin II receptor blockers (ARBs) and calcium channel blockers
ATC C09DB07 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS
Angiotensin II receptor blockers (ARBs) and calcium channel blockers
ATC C09DB09 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS
Angiotensin II receptor blockers (ARBs) and calcium channel blockers
ATC C09DX01 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS
Angiotensin II receptor blockers (ARBs), other combinations
ATC C09DX03 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS
Angiotensin II receptor blockers (ARBs), other combinations
ATC C09DX06 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS
Angiotensin II receptor blockers (ARBs), other combinations
ATC C09DX07 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS
Angiotensin II receptor blockers (ARBs), other combinations
ATC C09DX08 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
ANGIOTENSIN II RECEPTOR BLOCKERS (ARBs), COMBINATIONS
Angiotensin II receptor blockers (ARBs), other combinations
ATC C09XA53 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
OTHER AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
Renin-inhibitors
ATC C09XA54 CARDIOVASCULAR SYSTEM
AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
OTHER AGENTS ACTING ON THE RENIN-ANGIOTENSIN SYSTEM
Renin-inhibitors
ATC C10BX03 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
ATC C10BX07 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
ATC C10BX09 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
ATC C10BX11 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
ATC C10BX14 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
ATC C10BX18 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
ATC C10BX19 CARDIOVASCULAR SYSTEM
LIPID MODIFYING AGENTS
LIPID MODIFYING AGENTS, COMBINATIONS
Lipid modifying agents in combination with other drugs
FDA CS M0006414 Dihydropyridines
FDA MoA N0000000069 Calcium Channel Antagonists
FDA EPC N0000175421 Dihydropyridine Calcium Channel Blocker
FDA EPC N0000175566 Calcium Channel Blocker
CHEBI has role CHEBI:35620 vasodilator agents
CHEBI has role CHEBI:35674 antihypertensive drugs
CHEBI has role CHEBI:38215 calcium channel blockers
FDA MoA N0000190114 Cytochrome P450 3A Inhibitors
MeSH PA D000959 Antihypertensive Agents
MeSH PA D002121 Calcium Channel Blockers
MeSH PA D000077264 Calcium-Regulating Hormones and Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D049990 Membrane Transport Modulators
MeSH PA D014665 Vasodilator Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Hypertensive disorder indication 38341003 DOID:10763
Prinzmetal angina indication 87343002
Angina pectoris indication 194828000
Cerebrovascular accident indication 230690007
Primary Prevention of Coronary Heart Disease indication
Myocardial Infarction Prevention indication
Anuria contraindication 2472002 DOID:2983
Alcoholism contraindication 7200002
Hyperkalemia contraindication 14140009
Jaundice contraindication 18165001
Secondary angle-closure glaucoma contraindication 21571006
Hypovolemia contraindication 28560003
Obstruction of bile duct contraindication 30144000
Dehydration contraindication 34095006
Hyperuricemia contraindication 35885006 DOID:1920
Hypothyroidism contraindication 40930008 DOID:1459
Angioedema contraindication 41291007 DOID:1558
Hypokalemia contraindication 43339004
Diabetes mellitus type 2 contraindication 44054006 DOID:9352
Low blood pressure contraindication 45007003
Systemic lupus erythematosus contraindication 55464009 DOID:9074
Sympathectomy contraindication 57071006
Acute nephropathy contraindication 58574008
Hepatic failure contraindication 59927004
Hypercalcemia contraindication 66931009 DOID:12678
Hyperparathyroidism contraindication 66999008 DOID:13543
Hypochloremic alkalosis contraindication 70134007
Hepatic coma contraindication 72836002 DOID:12550
Diabetes mellitus contraindication 73211009 DOID:9351
Chronic idiopathic constipation contraindication 82934008
Hereditary angioneurotic edema contraindication 82966003 DOID:14735
Hyponatremia contraindication 89627008
Gout contraindication 90560007 DOID:13189
Kidney disease contraindication 90708001 DOID:557
Disorder of connective tissue contraindication 105969002 DOID:65
Disorder of muscle contraindication 129565002 DOID:423
Liver function tests abnormal contraindication 166603001
Hypomagnesemia contraindication 190855004
Acute pancreatitis contraindication 197456007 DOID:2913
Impaired renal function disorder contraindication 197663003
Hemorrhagic cerebral infarction contraindication 230706003
Disease of liver contraindication 235856003 DOID:409
Rhabdomyolysis contraindication 240131006
Neonatal hyperbilirubinemia contraindication 281610001
Pregnancy, function contraindication 289908002
Renal artery stenosis contraindication 302233006
Neutropenic disorder contraindication 303011007 DOID:1227
Bone marrow depression contraindication 307762000
Surgical procedure contraindication 387713003
Breastfeeding (mother) contraindication 413712001
Traumatic injury contraindication 417746004
Azotemia contraindication 445009001
Head and Neck Angioedema contraindication
Hemodialysis with High-Flux Membrane contraindication
Severe Aortic Valve Stenosis contraindication
Intestinal Angioedema contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.0 Basic
pKa2 1.55 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
EQ 10MG BASE;14MG PRESTALIA ADHERA N205003 Jan. 21, 2015 RX TABLET ORAL 6696481 April 15, 2023 TREATMENT OF HYPERTENSION
EQ 2.5MG BASE;3.5MG PRESTALIA ADHERA N205003 Jan. 21, 2015 RX TABLET ORAL 6696481 April 15, 2023 TREATMENT OF HYPERTENSION
EQ 5MG BASE;7MG PRESTALIA ADHERA N205003 Jan. 21, 2015 RX TABLET ORAL 6696481 April 15, 2023 TREATMENT OF HYPERTENSION
EQ 10MG BASE;200MG CONSENSI PURPLE BIOTECH N210045 May 31, 2018 DISCN TABLET ORAL 9662315 May 22, 2029 TREATMENT OF ADULT PATIENTS FOR WHOM TREATMENT WITH BOTH AMLODIPINE FOR HYPERTENSION AND CELECOXIB FOR OSTEOARTHRITIS ARE APPROPRIATE
EQ 2.5MG BASE;200MG CONSENSI PURPLE BIOTECH N210045 May 31, 2018 DISCN TABLET ORAL 9662315 May 22, 2029 TREATMENT OF ADULT PATIENTS FOR WHOM TREATMENT WITH BOTH AMLODIPINE FOR HYPERTENSION AND CELECOXIB FOR OSTEOARTHRITIS ARE APPROPRIATE
EQ 5MG BASE;200MG CONSENSI PURPLE BIOTECH N210045 May 31, 2018 DISCN TABLET ORAL 9662315 May 22, 2029 TREATMENT OF ADULT PATIENTS FOR WHOM TREATMENT WITH BOTH AMLODIPINE FOR HYPERTENSION AND CELECOXIB FOR OSTEOARTHRITIS ARE APPROPRIATE
EQ 10MG BASE;14MG PRESTALIA ADHERA N205003 Jan. 21, 2015 RX TABLET ORAL 7846961 Oct. 5, 2029 TREATMENT OF HYPERTENSION
EQ 2.5MG BASE;3.5MG PRESTALIA ADHERA N205003 Jan. 21, 2015 RX TABLET ORAL 7846961 Oct. 5, 2029 TREATMENT OF HYPERTENSION
EQ 5MG BASE;7MG PRESTALIA ADHERA N205003 Jan. 21, 2015 RX TABLET ORAL 7846961 Oct. 5, 2029 TREATMENT OF HYPERTENSION
EQ 10MG BASE;200MG CONSENSI PURPLE BIOTECH N210045 May 31, 2018 DISCN TABLET ORAL 9408837 Feb. 28, 2030 TREATMENT OF ADULT PATIENTS FOR WHOM TREATMENT WITH BOTH AMLODIPINE FOR HYPERTENSION AND CELECOXIB FOR OSTEOARTHRITIS ARE APPROPRIATE
EQ 2.5MG BASE;200MG CONSENSI PURPLE BIOTECH N210045 May 31, 2018 DISCN TABLET ORAL 9408837 Feb. 28, 2030 TREATMENT OF ADULT PATIENTS FOR WHOM TREATMENT WITH BOTH AMLODIPINE FOR HYPERTENSION AND CELECOXIB FOR OSTEOARTHRITIS ARE APPROPRIATE
EQ 5MG BASE;200MG CONSENSI PURPLE BIOTECH N210045 May 31, 2018 DISCN TABLET ORAL 9408837 Feb. 28, 2030 TREATMENT OF ADULT PATIENTS FOR WHOM TREATMENT WITH BOTH AMLODIPINE FOR HYPERTENSION AND CELECOXIB FOR OSTEOARTHRITIS ARE APPROPRIATE
EQ 10MG BASE;200MG CONSENSI PURPLE BIOTECH N210045 May 31, 2018 DISCN TABLET ORAL 10925835 June 14, 2038 TREATMENT OF ADULT PATIENTS FOR WHOM TREATMENT WITH BOTH AMLODIPINE FOR HYPERTENSION AND CELECOXIB FOR OSTEOARTHRITIS ARE APPROPRIATE
EQ 2.5MG BASE;200MG CONSENSI PURPLE BIOTECH N210045 May 31, 2018 DISCN TABLET ORAL 10925835 June 14, 2038 TREATMENT OF ADULT PATIENTS FOR WHOM TREATMENT WITH BOTH AMLODIPINE FOR HYPERTENSION AND CELECOXIB FOR OSTEOARTHRITIS ARE APPROPRIATE
EQ 5MG BASE;200MG CONSENSI PURPLE BIOTECH N210045 May 31, 2018 DISCN TABLET ORAL 10925835 June 14, 2038 TREATMENT OF ADULT PATIENTS FOR WHOM TREATMENT WITH BOTH AMLODIPINE FOR HYPERTENSION AND CELECOXIB FOR OSTEOARTHRITIS ARE APPROPRIATE
EQ 1MG BASE/ML NORLIQVA CMP DEV LLC N214439 Feb. 24, 2022 RX SOLUTION ORAL 11253474 Feb. 24, 2041 NORLIQVA IS INDICATED FOR THE SYMPTOMATIC TREATMENT OF CHRONIC STABLE ANGINA
EQ 1MG BASE/ML NORLIQVA CMP DEV LLC N214439 Feb. 24, 2022 RX SOLUTION ORAL 11253474 Feb. 24, 2041 NORLIQVA IS INDICATED FOR THE TREATMENT OF CONFIRMED OR SUSPECTED VASOSPASTIC ANGINA
EQ 1MG BASE/ML NORLIQVA CMP DEV LLC N214439 Feb. 24, 2022 RX SOLUTION ORAL 11253474 Feb. 24, 2041 NORLIQVA IS INDICATED FOR THE TREATMENT OF HYPERTENSION, TO LOWER BLOOD PRESSURE IN ADULTS AND CHILDREN 6 YEARS OF AGE AND OLDER
EQ 1MG BASE/ML NORLIQVA CMP DEV LLC N214439 Feb. 24, 2022 RX SOLUTION ORAL 11458095 Feb. 24, 2041 NORLIQVA IS INDICATED FOR THE SYMPTOMATIC TREATMENT OF CHRONIC STABLE ANGINA
EQ 1MG BASE/ML NORLIQVA CMP DEV LLC N214439 Feb. 24, 2022 RX SOLUTION ORAL 11458095 Feb. 24, 2041 NORLIQVA IS INDICATED FOR THE TREATMENT OF CONFIRMED OR SUSPECTED VASOSPASTIC ANGINA
EQ 1MG BASE/ML NORLIQVA CMP DEV LLC N214439 Feb. 24, 2022 RX SOLUTION ORAL 11458095 Feb. 24, 2041 NORLIQVA IS INDICATED FOR THE TREATMENT OF HYPERTENSION, TO LOWER BLOOD PRESSURE IN ADULTS AND CHILDREN 6 YEARS OF AGE AND OLDER

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Voltage-dependent L-type calcium channel subunit alpha-1C Ion channel BLOCKER WOMBAT-PK CHEMBL
Voltage-dependent L-type calcium channel subunit alpha-1D Ion channel BLOCKER Ki 7 WOMBAT-PK CHEMBL
Alpha-1A adrenergic receptor GPCR Ki 5.63 CHEMBL
Aldehyde oxidase Enzyme IC50 5.26 WOMBAT-PK
Alpha-2C adrenergic receptor GPCR Ki 6.58 DRUG MATRIX
Sodium-dependent dopamine transporter Transporter Ki 5.36 DRUG MATRIX
Alpha-1D adrenergic receptor GPCR Ki 5.27 CHEMBL
Alpha-1B adrenergic receptor GPCR Ki 5.10 CHEMBL
Voltage-dependent calcium channel gamma-1 subunit Ion channel Ki 7.20 WOMBAT-PK
Carbonic anhydrase 1 Enzyme WOMBAT-PK
Voltage-dependent calcium channel subunit alpha-2/delta-1 Ion channel Ki 7.20 WOMBAT-PK
Voltage-dependent T-type calcium channel subunit alpha-1H Ion channel Ki 4.51 WOMBAT-PK
Potassium channel subfamily K member 2 Ion channel IC50 6.40 CHEMBL
Alpha-2A adrenergic receptor GPCR Ki 6.65 DRUG MATRIX
5-hydroxytryptamine receptor 6 GPCR Ki 5.87 DRUG MATRIX
Voltage-dependent L-type calcium channel subunit alpha-1C Ion channel Ki 8.70 CHEMBL
Potassium channel subfamily K member 2 Ion channel IC50 6.37 CHEMBL

External reference:

IDSource
4020813 VUID
N0000148333 NUI
D00615 KEGG_DRUG
111470-99-6 SECONDARY_CAS_RN
104416 RXNORM
C0051696 UMLSCUI
CHEBI:2669 CHEBI
06X PDB_CHEM_ID
CHEMBL1491 ChEMBL_ID
CHEMBL1200402 ChEMBL_ID
D017311 MESH_DESCRIPTOR_UI
DB00381 DRUGBANK_ID
2162 PUBCHEM_CID
6981 IUPHAR_LIGAND_ID
5729 INN_ID
88150-47-4 SECONDARY_CAS_RN
246852-12-0 SECONDARY_CAS_RN
1J444QC288 UNII
108736 MMSL
173594 MMSL
23944 MMSL
27341 MMSL
4180 MMSL
d00689 MMSL
108537001 SNOMEDCT_US
1193663008 SNOMEDCT_US
384976003 SNOMEDCT_US
386864001 SNOMEDCT_US
421048000 SNOMEDCT_US
CHEMBL1200984 ChEMBL_ID
4020586 VANDF
4020813 VANDF
003672 NDDF
003673 NDDF
008599 NDDF
015579 NDDF

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Norvasc HUMAN PRESCRIPTION DRUG LABEL 1 0069-1520 TABLET 2.50 mg ORAL NDA 26 sections
Norvasc HUMAN PRESCRIPTION DRUG LABEL 1 0069-1520 TABLET 2.50 mg ORAL NDA 26 sections
Norvasc HUMAN PRESCRIPTION DRUG LABEL 1 0069-1520 TABLET 2.50 mg ORAL NDA 26 sections
Norvasc HUMAN PRESCRIPTION DRUG LABEL 1 0069-1530 TABLET 5 mg ORAL NDA 26 sections
Norvasc HUMAN PRESCRIPTION DRUG LABEL 1 0069-1530 TABLET 5 mg ORAL NDA 26 sections
Norvasc HUMAN PRESCRIPTION DRUG LABEL 1 0069-1530 TABLET 5 mg ORAL NDA 26 sections
Norvasc HUMAN PRESCRIPTION DRUG LABEL 1 0069-1540 TABLET 10 mg ORAL NDA 26 sections
Norvasc HUMAN PRESCRIPTION DRUG LABEL 1 0069-1540 TABLET 10 mg ORAL NDA 26 sections
Norvasc HUMAN PRESCRIPTION DRUG LABEL 1 0069-1540 TABLET 10 mg ORAL NDA 26 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2150 TABLET, FILM COATED 5 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2150 TABLET, FILM COATED 5 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2150 TABLET, FILM COATED 5 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2150 TABLET, FILM COATED 5 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2160 TABLET, FILM COATED 10 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2160 TABLET, FILM COATED 10 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2160 TABLET, FILM COATED 10 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2160 TABLET, FILM COATED 10 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2170 TABLET, FILM COATED 5 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2170 TABLET, FILM COATED 5 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2170 TABLET, FILM COATED 5 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2170 TABLET, FILM COATED 5 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2180 TABLET, FILM COATED 10 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2180 TABLET, FILM COATED 10 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2180 TABLET, FILM COATED 10 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2180 TABLET, FILM COATED 10 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2190 TABLET, FILM COATED 5 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2190 TABLET, FILM COATED 5 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2190 TABLET, FILM COATED 5 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2190 TABLET, FILM COATED 5 mg ORAL NDA 32 sections
Caduet HUMAN PRESCRIPTION DRUG LABEL 2 0069-2250 TABLET, FILM COATED 10 mg ORAL NDA 32 sections