cinchocaine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
local anaesthetics	859	85-79-0

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: cinchocaine dermacaine dibucaine nupercaine percamine dibucaine hydrochloride dibucaine HCl	A local anesthetic of the amide type now generally used for surface anesthesia. It is one of the most potent and toxic of the long-acting local anesthetics and its parenteral use is restricted to spinal anesthesia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1006) Molecular weight: 343.47 Formula: C20H29N3O2 CLOGP: 5.42 LIPINSKI: 1 HAC: 5 HDO: 1 TPSA: 54.46 ALOGS: -3.95 ROTB: 10 Status: OFM Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

cinchocaine
dermacaine
dibucaine
nupercaine
percamine
dibucaine hydrochloride
dibucaine HCl

A local anesthetic of the amide type now generally used for surface anesthesia. It is one of the most potent and toxic of the long-acting local anesthetics and its parenteral use is restricted to spinal anesthesia. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1006)

Molecular weight: 343.47
Formula: C20H29N3O2
CLOGP: 5.42
LIPINSKI: 1
HAC: 5
HDO: 1
TPSA: 54.46
ALOGS: -3.95
ROTB: 10

Status: OFM

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
None	FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

Show entries

Search:

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Heart sounds	63.13	58.51	10	546	956	79742876
Prolonged expiration	60.39	58.51	10	546	1261	79742571

Showing 1 to 2 of 2 entries

Previous1Next

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Show entries

Search:

Source	Code	Description
ATC	C05AD04	CARDIOVASCULAR SYSTEM VASOPROTECTIVES AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE Local anesthetics
ATC	D04AB02	DERMATOLOGICALS ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC. ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC. Anesthetics for topical use
ATC	N01BB06	NERVOUS SYSTEM ANESTHETICS ANESTHETICS, LOCAL Amides
ATC	S01HA06	SENSORY ORGANS OPHTHALMOLOGICALS LOCAL ANESTHETICS Local anesthetics
ATC	S02DA04	SENSORY ORGANS OTOLOGICALS OTHER OTOLOGICALS Analgesics and anesthetics
CHEBI has role	CHEBI:48425	topical anesthetic
FDA CS	M0000728	Allergens
FDA EPC	N0000185508	Standardized Chemical Allergen
FDA PE	N0000175629	Increased Histamine Release
FDA PE	N0000184306	Cell-mediated Immunity

Showing 1 to 10 of 16 entries

Previous1 2Next

Drug Use | Suggest Off label Use Form| |View source of the data|

Show entries

Search:

Disease	Relation	SNOMED_ID	DOID
Skin irritation	indication	367466007
Itching of skin	indication	418363000
Minor Skin Wound Pain	indication
Conduction disorder of the heart	contraindication	44808001
Disorder of cardiovascular system	contraindication	49601007	DOID:1287
Bleeding hemorrhoids	contraindication	51551000
Decreased respiratory function	contraindication	80954004
Kidney disease	contraindication	90708001	DOID:557
Myasthenia gravis	contraindication	91637004	DOID:437
Disorder of mucous membrane	contraindication	95351003

Showing 1 to 10 of 15 entries

Previous1 2Next

🐶 Veterinary Drug Use

Species	Use	Relation
Dogs	Euthanasia	Indication

🐶 Veterinary products

Product	Applicant	Ingredients
Repose Euthanasia Solution	Zoetis Inc.	2

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	13.24	acidic
pKa2	9.02	Basic
pKa3	3.84	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Show entries

Search:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Bioact source	MoA source
Sodium channel protein type 5 subunit alpha	Ion channel	Q14524	SCN5A_HUMAN	BLOCKER			DRUGBANK	CHEMBL
Sodium channel protein type 10 subunit alpha	Ion channel	Q9Y5Y9	SCNAA_HUMAN	BLOCKER			DRUGBANK	CHEMBL
Sodium channel alpha subunits; brain (Types I, II, III)	Ion channel	P35498 Q99250 Q9NY46	SCN1A_HUMAN SCN2A_HUMAN SCN3A_HUMAN		IC50	5.85	CHEMBL

Showing 1 to 3 of 3 entries

Previous1Next

External reference:

Show entries

Search:

ID	Source
001371	NDDF
001372	NDDF
108	INN_ID
14979	MMSL
235402	RXNORM
3025	PUBCHEM_CID
349831001	SNOMEDCT_US
395953008	SNOMEDCT_US
39808001	SNOMEDCT_US
4018897	VUID

Showing 1 to 10 of 25 entries

Previous1 2 3Next

Pharmaceutical products:

Show entries

Search:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
CVS Hemorrhoidal Topical Analgesic	HUMAN OTC DRUG LABEL	1	59779-997	OINTMENT	10 mg	TOPICAL	OTC monograph final	13 sections
DIBUCAINE	HUMAN OTC DRUG LABEL	1	0168-0046	OINTMENT	1 g	TOPICAL	OTC monograph final	9 sections
dibucaine	HUMAN OTC DRUG LABEL	1	45802-050	OINTMENT	1 g	TOPICAL	OTC monograph final	14 sections
Dibucaine	HUMAN OTC DRUG LABEL	1	54162-011	OINTMENT	0.28 g	TOPICAL	OTC monograph final	9 sections
Dibucaine	HUMAN OTC DRUG LABEL	1	57896-131	OINTMENT	1 g	TOPICAL	OTC monograph final	14 sections
DIBUCAINE	HUMAN OTC DRUG LABEL	1	59779-398	CREAM	10 mg	TOPICAL	OTC monograph final	7 sections
Dibucaine	HUMAN OTC DRUG LABEL	1	63868-911	OINTMENT	1 g	TOPICAL	OTC monograph final	15 sections
Dibucaine	HUMAN OTC DRUG LABEL	1	63868-911	OINTMENT	1 g	TOPICAL	OTC monograph final	15 sections
Dibucaine	HUMAN OTC DRUG LABEL	1	69396-023	OINTMENT	1 g	TOPICAL	OTC monograph final	15 sections
Dibucaine	HUMAN OTC DRUG LABEL	1	71399-2829	OINTMENT	0.28 g	TOPICAL	OTC monograph final	9 sections

Showing 1 to 10 of 18 entries

Previous1 2Next