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oxetacaine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| local anaesthetics | 3407 | 126-27-2 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
isolated from bioactive leaf extracts of Rollinia mucosa
|
Drug dosage:
None
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2B,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK4,CDK5,CDK9,EIF2AK3,EPHB4,ERBB2,GRK2,ITK,MAP3K7,MAPK7,NTRK2,PDK1,PDK2,PDK4,PIK3CB,PRKDC,SIK2,SIK3,TEK,TGFBR1 | 26 | |||
| kinase-selectivity-class | AXL,BRAF,EPHB4,ERBB2,GRK2,SIK2 | 6 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
None
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Hydronephrosis | 100.97 | 67.21 | 20 | 336 | 12382 | 90615709 |
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Hydronephrosis | 90.70 | 53.65 | 20 | 414 | 20645 | 110568220 |
| Constipation | 55 | 53.65 | 27 | 407 | 357759 | 110231106 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | C05AD06 | CARDIOVASCULAR SYSTEM VASOPROTECTIVES AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE Local anesthetics |
| MeSH PA | D000777 | Anesthetics |
| MeSH PA | D000779 | Anesthetics, Local |
| MeSH PA | D002491 | Central Nervous System Agents |
| MeSH PA | D002492 | Central Nervous System Depressants |
| MeSH PA | D018373 | Peripheral Nervous System Agents |
| MeSH PA | D018689 | Sensory System Agents |
Related Drugs by ATC class:
C05AD Local anesthetics 6 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 11.47 | acidic |
| pKa2 | 5.07 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Sodium channel alpha subunits; brain (Types I, II, III) | Ion channel | IC50 | 5.64 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| D01152 | KEGG_DRUG |
| CHEBI:31947 | CHEBI |
| CHEMBL127592 | ChEMBL_ID |
| CHEMBL451445 | ChEMBL_ID |
| DB12532 | DRUGBANK_ID |
| 001342 | NDDF |
| 111134000 | SNOMEDCT_US |
| 425185000 | SNOMEDCT_US |
| C0069758 | UMLSCUI |
| 4621 | PUBCHEM_CID |
| 1342 | INN_ID |
| C100289 | MESH_SUPPLEMENTAL_RECORD_UI |
| C515333 | MESH_SUPPLEMENTAL_RECORD_UI |
| IP8QT76V17 | UNII |
Pharmaceutical products:
None