pramocaine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| local anaesthetics | 3487 | 140-65-8 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
None
ADMET properties:
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Aug. 13, 1976 | FDA | SEBELA IRELAND LTD |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Macular degeneration | 211.45 | 16.87 | 67 | 4570 | 12294 | 53332135 |
| Salpingo-oophorectomy unilateral | 114.76 | 16.87 | 23 | 4614 | 643 | 53343786 |
| Sinusitis fungal | 92.55 | 16.87 | 22 | 4615 | 1376 | 53343053 |
| Sputum increased | 86.94 | 16.87 | 23 | 4614 | 2223 | 53342206 |
| Respiratory symptom | 83.18 | 16.87 | 23 | 4614 | 2626 | 53341803 |
| Nasal polyps | 80.53 | 16.87 | 23 | 4614 | 2953 | 53341476 |
| Embolism venous | 80.36 | 16.87 | 23 | 4614 | 2976 | 53341453 |
| Female genital tract fistula | 77.70 | 16.87 | 24 | 4613 | 4034 | 53340395 |
| Diastolic dysfunction | 69.10 | 16.87 | 24 | 4613 | 5820 | 53338609 |
| Chronic sinusitis | 64.87 | 16.87 | 23 | 4614 | 5922 | 53338507 |
| Hysterectomy | 56.71 | 16.87 | 23 | 4614 | 8538 | 53335891 |
| Emphysema | 56.66 | 16.87 | 24 | 4613 | 9935 | 53334494 |
| Faecal volume decreased | 53.23 | 16.87 | 10 | 4627 | 197 | 53344232 |
| Diverticulum | 49.65 | 16.87 | 23 | 4614 | 11756 | 53332673 |
| Eczema | 46.68 | 16.87 | 28 | 4609 | 24154 | 53320275 |
| Tricuspid valve incompetence | 45.26 | 16.87 | 23 | 4614 | 14373 | 53330056 |
| Iron deficiency anaemia | 45.16 | 16.87 | 25 | 4612 | 18555 | 53325874 |
| Hiatus hernia | 43.89 | 16.87 | 25 | 4612 | 19595 | 53324834 |
| Obstructive airways disorder | 41.13 | 16.87 | 23 | 4614 | 17406 | 53327023 |
| Sleep apnoea syndrome | 39.83 | 16.87 | 26 | 4611 | 25976 | 53318453 |
| Disease recurrence | 39.77 | 16.87 | 24 | 4613 | 20922 | 53323507 |
| Fungal infection | 39.32 | 16.87 | 28 | 4609 | 32218 | 53312211 |
| Candida infection | 38.05 | 16.87 | 25 | 4612 | 25248 | 53319181 |
| Nail infection | 34.11 | 16.87 | 11 | 4626 | 2123 | 53342306 |
| Dyspnoea exertional | 33.70 | 16.87 | 32 | 4605 | 54968 | 53289461 |
| Deep vein thrombosis | 32.49 | 16.87 | 38 | 4599 | 82875 | 53261554 |
| Mucous stools | 30.34 | 16.87 | 11 | 4626 | 3015 | 53341414 |
| Haematochezia | 24.72 | 16.87 | 24 | 4613 | 42334 | 53302095 |
| Osteoporosis | 24.66 | 16.87 | 25 | 4612 | 46435 | 53297994 |
| Pulmonary embolism | 22.96 | 16.87 | 38 | 4599 | 114404 | 53230025 |
| Jarisch-Herxheimer reaction | 21.10 | 16.87 | 5 | 4632 | 308 | 53344121 |
| Oedema peripheral | 20.98 | 16.87 | 46 | 4591 | 170741 | 53173688 |
| Chest discomfort | 19.86 | 16.87 | 33 | 4604 | 99662 | 53244767 |
| Wheezing | 19.30 | 16.87 | 26 | 4611 | 65249 | 53279180 |
| Dermatophytosis | 18.56 | 16.87 | 4 | 4633 | 160 | 53344269 |
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | C05AD07 | CARDIOVASCULAR SYSTEM VASOPROTECTIVES AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE Local anesthetics |
| ATC | D04AB07 | DERMATOLOGICALS ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC. ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC. Anesthetics for topical use |
| MeSH PA | D000777 | Anesthetics |
| MeSH PA | D000779 | Anesthetics, Local |
| MeSH PA | D002491 | Central Nervous System Agents |
| MeSH PA | D002492 | Central Nervous System Depressants |
| MeSH PA | D018373 | Peripheral Nervous System Agents |
| MeSH PA | D018689 | Sensory System Agents |
| CHEBI has role | CHEBI:36333 | local anaesthetics |
Drug Use (View source of the data)
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Otitis externa | indication | 3135009 | |
| Proctitis | indication | 3951002 | DOID:3127 |
| Tinea pedis | indication | 6020002 | DOID:12403 |
| Wound | indication | 13924000 | |
| Dry skin | indication | 16386004 | |
| Burn injury | indication | 48333001 | |
| Hemorrhoids | indication | 70153002 | DOID:9746 |
| Rectal pain | indication | 77880009 | |
| Tinea corporis | indication | 84849002 | |
| Pruritus ani | indication | 90446007 | |
| Eruption of skin | indication | 271807003 | DOID:0050486 |
| Skin irritation | indication | 367466007 | |
| Tinea cruris | indication | 399029005 | |
| Allergic otitis externa | indication | 405821001 | |
| Arthropod bite wound | indication | 409985002 | |
| Itching of skin | indication | 418363000 | |
| Itching of ear | indication | 699392007 | |
| Inflammatory dermatosis | indication | 703938007 | |
| Prevent Minor Bacterial Skin Infection | indication | ||
| Minor Skin Wound Pain | indication | ||
| Minor Bacterial Skin Infections | indication | ||
| Mycosis | contraindication | 3218000 | DOID:1564 |
| Measles | contraindication | 14189004 | DOID:8622 |
| Herpes zoster auricularis | contraindication | 21954000 | DOID:9210 |
| Abscess of intestine | contraindication | 24557004 | |
| Acute tuberculosis | contraindication | 25629007 | |
| Hyperthyroidism | contraindication | 34486009 | DOID:7998 |
| Gastrointestinal fistula | contraindication | 37831005 | |
| Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
| Contact dermatitis | contraindication | 40275004 | DOID:2773 |
| Infectious disease | contraindication | 40733004 | |
| Hypothyroidism | contraindication | 40930008 | DOID:1459 |
| Conduction disorder of the heart | contraindication | 44808001 | |
| Skin ulcer | contraindication | 46742003 | |
| Chronic heart failure | contraindication | 48447003 | |
| Anxiety | contraindication | 48694002 | |
| Perforation of tympanic membrane | contraindication | 60442001 | |
| Osteoporosis | contraindication | 64859006 | DOID:11476 |
| Psychotic disorder | contraindication | 69322001 | |
| Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
| Third degree burn injury | contraindication | 80247002 | |
| Open-angle glaucoma | contraindication | 84494001 | DOID:1067 |
| Herpes simplex | contraindication | 88594005 | DOID:8566 |
| Kidney disease | contraindication | 90708001 | DOID:557 |
| Fissure in skin | contraindication | 95321009 | |
| Open wound | contraindication | 125643001 | |
| Tuberculosis of ear | contraindication | 186269001 | |
| Ophthalmic herpes simplex | contraindication | 186542001 | |
| Anastomosis of intestine | contraindication | 235407009 | |
| Telangiectasia disorder | contraindication | 247479008 | |
| Benign prostatic hyperplasia | contraindication | 266569009 | |
| Diverticulitis of gastrointestinal tract | contraindication | 271366000 | |
| Varicella-zoster virus infection | contraindication | 309465005 | |
| Viral ear infection | contraindication | 312137007 | |
| Fungal ear infection | contraindication | 312148000 | |
| Adrenal cortical hypofunction | contraindication | 386584007 | DOID:10493 |
| Atrophoderma | contraindication | 399979006 | |
| Peripheral vascular disease | contraindication | 400047006 | |
| Disorder of coronary artery | contraindication | 414024009 | |
| Denuded skin | contraindication | 418242004 | |
| Nervousness | contraindication |
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 7.65 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Sigma non-opioid intracellular receptor 1 | Membrane receptor | Ki | 7.29 | DRUG MATRIX | |||||
| Sodium channel alpha subunits; brain (Types I, II, III) | Ion channel | IC50 | 4.67 | CHEMBL | |||||
| Membrane-associated progesterone receptor component 1 | Membrane receptor | Ki | 6.20 | DRUG MATRIX |
External reference:
| ID | Source |
|---|---|
| 4018983 | VUID |
| N0000171570 | NUI |
| D00739 | KEGG_DRUG |
| 637-58-1 | SECONDARY_CAS_RN |
| 4018197 | VANDF |
| 4018983 | VANDF |
| C0071810 | UMLSCUI |
| CHEBI:8357 | CHEBI |
| PX9 | PDB_CHEM_ID |
| CHEMBL1198 | ChEMBL_ID |
| CHEMBL1201171 | ChEMBL_ID |
| DB09345 | DRUGBANK_ID |
| C005548 | MESH_SUPPLEMENTAL_RECORD_UI |
| 235 | INN_ID |
| 068X84E056 | UNII |
| 4886 | PUBCHEM_CID |
| 34347 | RXNORM |
| 5341 | MMSL |
| 5342 | MMSL |
| 72272 | MMSL |
| 001359 | NDDF |
| 004571 | NDDF |
| 31872002 | SNOMEDCT_US |
| 387175007 | SNOMEDCT_US |
| 387284004 | SNOMEDCT_US |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| PROCTOFOAMHC | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0037-6822 | AEROSOL, FOAM | 100 mg | TOPICAL | ANDA | 22 sections |
| PROCTOFOAMNS | HUMAN OTC DRUG LABEL | 1 | 0037-6823 | AEROSOL, FOAM | 150 mg | RECTAL | OTC monograph final | 11 sections |
| EPIFOAM | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0037-6824 | AEROSOL, FOAM | 100 mg | TOPICAL | ANDA | 20 sections |
| Good Sense Triple Antibioticand Pain Relief | HUMAN OTC DRUG LABEL | 4 | 0113-0679 | OINTMENT | 10 mg | TOPICAL | OTC monograph final | 13 sections |
| Good Sense HemorrhoidalMaximum Strength Pain Relief | HUMAN OTC DRUG LABEL | 4 | 0113-0944 | CREAM | 1 g | TOPICAL | OTC monograph final | 15 sections |
| good sense triple antibiotic | HUMAN OTC DRUG LABEL | 4 | 0113-1140 | OINTMENT | 10 mg | TOPICAL | OTC monograph final | 13 sections |
| Basic Care First Aid Antibiotic Plus Pain Relief | HUMAN OTC DRUG LABEL | 4 | 0113-7679 | OINTMENT | 10 mg | TOPICAL | OTC monograph final | 13 sections |
| Caladryl | HUMAN OTC DRUG LABEL | 3 | 0187-5465 | LOTION | 10 mg | TOPICAL | OTC monograph final | 14 sections |
| Caladryl Clear | HUMAN OTC DRUG LABEL | 2 | 0187-5466 | LOTION | 10 mg | TOPICAL | OTC monograph final | 14 sections |
| ITCH X | HUMAN OTC DRUG LABEL | 2 | 0225-0495 | GEL | 1 g | TOPICAL | OTC monograph not final | 14 sections |
| ITCH-X | HUMAN OTC DRUG LABEL | 2 | 0225-0516 | SPRAY | 1 g | TOPICAL | OTC monograph not final | 13 sections |
| Sarna | HUMAN OTC DRUG LABEL | 1 | 0316-0230 | LOTION | 10 mg | TOPICAL | OTC monograph not final | 13 sections |
| Triple Antibiotic with Pain ReliefMaximum Strength | HUMAN OTC DRUG LABEL | 4 | 0363-0123 | OINTMENT | 10 mg | TOPICAL | OTC MONOGRAPH FINAL | 13 sections |
| Walgreen Anti-Itch | HUMAN OTC DRUG LABEL | 1 | 0363-0263 | LOTION | 1 g | TOPICAL | OTC monograph not final | 13 sections |
| Hemorrhoidal Cream | HUMAN OTC DRUG LABEL | 4 | 0363-0641 | CREAM | 1 g | TOPICAL | OTC monograph not final | 15 sections |
| Hemorrhoidal Cream | HUMAN OTC DRUG LABEL | 4 | 0363-0641 | CREAM | 1 g | TOPICAL | OTC monograph not final | 15 sections |
| First Aid Antibiotic | HUMAN OTC DRUG LABEL | 4 | 0363-0841 | OINTMENT | 10 mg | TOPICAL | OTC monograph final | 13 sections |
| Walgreens Maximum Strength Hemorrhoidal | HUMAN OTC DRUG LABEL | 4 | 0363-1760 | CREAM | 0.01 mg | TOPICAL | OTC monograph final | 13 sections |
| Walgreens Multi-Antibiotic with Pain Relief Cream | HUMAN OTC DRUG LABEL | 3 | 0363-2123 | CREAM | 10 mg | TOPICAL | OTC monograph not final | 9 sections |
| Triple Antibiotic | HUMAN OTC DRUG LABEL | 4 | 0363-2900 | OINTMENT | 10 mg | TOPICAL | OTC monograph final | 13 sections |
| MEDICATED ANTI-ITCHWell at Walgreens | HUMAN OTC DRUG LABEL | 2 | 0363-3231 | CREAM | 1 g | TOPICAL | OTC monograph not final | 12 sections |
| Walgreens Maximum Strength Triple Antibiotic With Pain Relief | HUMAN OTC DRUG LABEL | 4 | 0363-7872 | OINTMENT | 10 mg | TOPICAL | OTC monograph final | 11 sections |
| Calamine Plus Pramoxine HCl | HUMAN OTC DRUG LABEL | 3 | 0363-8588 | AEROSOL, SPRAY | 2.72 mg | TOPICAL | OTC monograph not final | 12 sections |
| Triple Antibiotic Plus Pain Relief | HUMAN OTC DRUG LABEL | 4 | 0363-8888 | OINTMENT | 10 mg | TOPICAL | OTC MONOGRAPH FINAL | 14 sections |
| Calamine | HUMAN OTC DRUG LABEL | 3 | 0363-9114 | LOTION | 10 mg | TOPICAL | OTC monograph final | 12 sections |
| Clear Anti-Itch | HUMAN OTC DRUG LABEL | 2 | 0363-9115 | LOTION | 1 mg | TOPICAL | OTC monograph final | 12 sections |
| Ivy Wash | HUMAN OTC DRUG LABEL | 1 | 0395-0119 | LOTION | 10 1 | TOPICAL | OTC monograph not final | 13 sections |
| Humco Calaclear | HUMAN OTC DRUG LABEL | 2 | 0395-0400 | LOTION | 10 mg | TOPICAL | OTC monograph final | 12 sections |
| Humco Calagesic | HUMAN OTC DRUG LABEL | 2 | 0395-0420 | LOTION | 10 mg | TOPICAL | OTC monograph final | 11 sections |
| Calaclear | HUMAN OTC DRUG LABEL | 2 | 0395-9108 | LOTION | 10 mg | TOPICAL | OTC monograph final | 12 sections |