pramocaine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
local anaesthetics	3487	140-65-8

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: pramocaine hydrochloride pramoxine pramoxine hydrochloride pramocain pramocaine pramoxin pramoxine HCl	Molecular weight: 293.41 Formula: C17H27NO3 CLOGP: 3.96 LIPINSKI: 0 HAC: 4 HDO: 0 TPSA: 30.93 ALOGS: -3.12 ROTB: 9 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

pramocaine hydrochloride
pramoxine
pramoxine hydrochloride
pramocain
pramocaine
pramoxin
pramoxine HCl

Molecular weight: 293.41
Formula: C17H27NO3
CLOGP: 3.96
LIPINSKI: 0
HAC: 4
HDO: 0
TPSA: 30.93
ALOGS: -3.12
ROTB: 9

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Aug. 13, 1976	FDA	SEBELA IRELAND LTD

FDA Adverse Event Reporting System (Female)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Macular degeneration	749.85	16.83	224	7535	24152	63457111
Chronic sinusitis	284.63	16.83	92	7667	12751	63468512
Procedural pain	199.48	16.83	81	7678	21488	63459775
Paraesthesia oral	197.79	16.83	78	7681	19178	63462085
Female genital tract fistula	142.69	16.83	48	7711	7511	63473752
Vaginal flatulence	112.89	16.83	33	7726	3260	63478003
Proctitis	100.51	16.83	34	7725	5407	63475856
Dyspepsia	92.77	16.83	86	7673	102110	63379153
Therapeutic product effect incomplete	88.81	16.83	92	7667	124964	63356299
Vaginal discharge	83.11	16.83	34	7725	9164	63472099

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FDA Adverse Event Reporting System (Male)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Anal inflammation	85.99	19.67	20	2690	1280	34952941
SARS-CoV-2 test negative	74.43	19.67	17	2693	1003	34953218
Accident	59.15	19.67	20	2690	5027	34949194
Proctalgia	56.68	19.67	20	2690	5703	34948518
Haemorrhoids	53.65	19.67	25	2685	14550	34939671
Body temperature increased	38.11	19.67	21	2689	17347	34936874
Erythema multiforme	26.24	19.67	13	2697	8636	34945585
Pruritus	25.43	19.67	42	2668	141939	34812282
Anticholinergic syndrome	22.96	19.67	7	2703	1262	34952959
Pyrexia	22.07	19.67	66	2644	332947	34621274

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FDA Adverse Event Reporting System (Geriatric)

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MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Chronic sinusitis	278.91	16.45	88	8417	12938	79722945
Macular degeneration	232.23	16.45	74	8431	11222	79724661
Procedural pain	194.35	16.45	78	8427	23006	79712877
Paraesthesia oral	192.75	16.45	75	8430	20396	79715487
Female genital tract fistula	155.90	16.45	47	8458	5928	79729955
Vaginal flatulence	120.59	16.45	32	8473	2543	79733340
Proctitis	95.57	16.45	33	8472	6399	79729484
Dyspepsia	94.27	16.45	84	8421	108603	79627280
Vaginal discharge	90.77	16.45	33	8472	7430	79728453
Radiculopathy	81.84	16.45	32	8473	8792	79727091

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FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

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Source	Code	Description
ATC	C05AD07	CARDIOVASCULAR SYSTEM VASOPROTECTIVES AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE Local anesthetics
ATC	D04AB07	DERMATOLOGICALS ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC. ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC. Anesthetics for topical use
CHEBI has role	CHEBI:36333	local anesthetics
MeSH PA	D000777	Anesthetics
MeSH PA	D000779	Anesthetics, Local
MeSH PA	D002491	Central Nervous System Agents
MeSH PA	D002492	Central Nervous System Depressants
MeSH PA	D018373	Peripheral Nervous System Agents
MeSH PA	D018689	Sensory System Agents

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Drug Use | Suggest Off label Use Form| |View source of the data|

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Disease	Relation	SNOMED_ID	DOID
Otitis externa	indication	3135009
Proctitis	indication	3951002	DOID:3127
Tinea pedis	indication	6020002	DOID:12403
Wound	indication	13924000
Dry skin	indication	16386004
Burn injury	indication	48333001
Hemorrhoids	indication	70153002	DOID:9746
Rectal pain	indication	77880009
Tinea corporis	indication	84849002
Pruritus ani	indication	90446007

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🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	7.65	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

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Target	Class	Pharos	UniProt	Type	Activity value (-log[M])	Bioact source
Sigma non-opioid intracellular receptor 1	Membrane receptor	Q99720	SGMR1_HUMAN	Ki	7.29	DRUG MATRIX
Sodium channel alpha subunits; brain (Types I, II, III)	Ion channel	P35498 Q99250 Q9NY46	SCN1A_HUMAN SCN2A_HUMAN SCN3A_HUMAN	IC50	4.67	CHEMBL
Membrane-associated progesterone receptor component 1	Membrane receptor		PGRC1_RAT	Ki	6.20	DRUG MATRIX

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External reference:

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ID	Source
PX9	PDB_CHEM_ID
001359	NDDF
004571	NDDF
068X84E056	UNII
235	INN_ID
31872002	SNOMEDCT_US
34347	RXNORM
387175007	SNOMEDCT_US
387284004	SNOMEDCT_US
4018197	VANDF

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Pharmaceutical products:

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Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Basic Care First Aid Antibiotic Plus Pain Relief	HUMAN OTC DRUG LABEL	4	0113-7679	OINTMENT	10 mg	TOPICAL	OTC monograph final	13 sections
Caladryl	HUMAN OTC DRUG LABEL	3	0187-5465	LOTION	10 mg	TOPICAL	OTC monograph final	14 sections
Caladryl	HUMAN OTC DRUG LABEL	3	0187-5465	LOTION	10 mg	TOPICAL	OTC monograph final	14 sections
Caladryl Clear	HUMAN OTC DRUG LABEL	2	0187-5466	LOTION	10 mg	TOPICAL	OTC monograph final	14 sections
EPIFOAM	HUMAN PRESCRIPTION DRUG LABEL	2	0037-6824	AEROSOL, FOAM	100 mg	TOPICAL	ANDA	20 sections
First Aid Antibiotic	HUMAN OTC DRUG LABEL	4	0363-0841	OINTMENT	10 mg	TOPICAL	OTC monograph final	13 sections
First Aid Antibiotic	HUMAN OTC DRUG LABEL	4	0363-0841	OINTMENT	10 mg	TOPICAL	OTC monograph final	13 sections
Good Sense HemorrhoidalMaximum Strength Pain Relief	HUMAN OTC DRUG LABEL	4	0113-0944	CREAM	1 g	TOPICAL	OTC monograph final	15 sections
good sense triple antibiotic	HUMAN OTC DRUG LABEL	4	0113-1140	OINTMENT	10 mg	TOPICAL	OTC monograph final	13 sections
Good Sense Triple Antibioticand Pain Relief	HUMAN OTC DRUG LABEL	4	0113-0679	OINTMENT	10 mg	TOPICAL	OTC monograph final	13 sections

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