Stem definition | Drug id | CAS RN |
---|---|---|
local anaesthetics | 3487 | 140-65-8 |
None
None
Date | Agency | Company | Orphan |
---|---|---|---|
Aug. 13, 1976 | FDA | SEBELA IRELAND LTD |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Macular degeneration | 410.24 | 16.36 | 114 | 4020 | 14274 | 50586716 |
Chronic sinusitis | 50.58 | 16.36 | 19 | 4115 | 6126 | 50594864 |
Drug ineffective | 33.99 | 16.36 | 144 | 3990 | 819189 | 49781801 |
Nail bed tenderness | 26.48 | 16.36 | 6 | 4128 | 323 | 50600667 |
Salpingo-oophorectomy unilateral | 23.51 | 16.36 | 6 | 4128 | 535 | 50600455 |
Sinusitis fungal | 22.40 | 16.36 | 7 | 4127 | 1299 | 50599691 |
Procedural pain | 22.39 | 16.36 | 14 | 4120 | 13818 | 50587172 |
Jarisch-Herxheimer reaction | 21.70 | 16.36 | 5 | 4129 | 290 | 50600700 |
Sputum increased | 19.94 | 16.36 | 7 | 4127 | 1860 | 50599130 |
Autonomic neuropathy | 19.79 | 16.36 | 6 | 4128 | 1007 | 50599983 |
Vulvovaginal swelling | 19.72 | 16.36 | 5 | 4129 | 435 | 50600555 |
Dermatophytosis | 18.91 | 16.36 | 4 | 4130 | 156 | 50600834 |
Paraesthesia oral | 18.85 | 16.36 | 12 | 4122 | 12209 | 50588781 |
Female genital tract fistula | 18.59 | 16.36 | 8 | 4126 | 3658 | 50597332 |
Respiratory symptom | 18.19 | 16.36 | 7 | 4127 | 2407 | 50598583 |
Embolism venous | 17.88 | 16.36 | 7 | 4127 | 2518 | 50598472 |
Nasal polyps | 17.81 | 16.36 | 7 | 4127 | 2547 | 50598443 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Erythema multiforme | 25.88 | 18.78 | 12 | 2040 | 7705 | 29564770 |
Pruritus | 21.58 | 18.78 | 33 | 2019 | 116816 | 29455659 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Chronic sinusitis | 43.47 | 17.14 | 17 | 5110 | 6275 | 64487330 |
Nail bed tenderness | 26.55 | 17.14 | 6 | 5121 | 328 | 64493277 |
Macular degeneration | 24.53 | 17.14 | 11 | 5116 | 5699 | 64487906 |
Pruritus | 24.51 | 17.14 | 67 | 5060 | 312333 | 64181272 |
Salpingo-oophorectomy unilateral | 24.19 | 17.14 | 6 | 5121 | 490 | 64493115 |
Vulvovaginal swelling | 21.36 | 17.14 | 5 | 5122 | 320 | 64493285 |
Female genital tract fistula | 21.29 | 17.14 | 8 | 5119 | 2650 | 64490955 |
Sinusitis fungal | 20.75 | 17.14 | 7 | 5120 | 1699 | 64491906 |
Embolism venous | 19.14 | 17.14 | 8 | 5119 | 3499 | 64490106 |
Procedural pain | 18.87 | 17.14 | 13 | 5114 | 15495 | 64478110 |
Erythema multiforme | 18.73 | 17.14 | 13 | 5114 | 15688 | 64477917 |
Jarisch-Herxheimer reaction | 17.64 | 17.14 | 5 | 5122 | 682 | 64492923 |
None
Source | Code | Description |
---|---|---|
ATC | C05AD07 | CARDIOVASCULAR SYSTEM VASOPROTECTIVES AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE Local anesthetics |
ATC | D04AB07 | DERMATOLOGICALS ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC. ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC. Anesthetics for topical use |
MeSH PA | D000777 | Anesthetics |
MeSH PA | D000779 | Anesthetics, Local |
MeSH PA | D002491 | Central Nervous System Agents |
MeSH PA | D002492 | Central Nervous System Depressants |
MeSH PA | D018373 | Peripheral Nervous System Agents |
MeSH PA | D018689 | Sensory System Agents |
CHEBI has role | CHEBI:36333 | local anesthetics |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Otitis externa | indication | 3135009 | |
Proctitis | indication | 3951002 | DOID:3127 |
Tinea pedis | indication | 6020002 | DOID:12403 |
Wound | indication | 13924000 | |
Dry skin | indication | 16386004 | |
Burn injury | indication | 48333001 | |
Hemorrhoids | indication | 70153002 | DOID:9746 |
Rectal pain | indication | 77880009 | |
Tinea corporis | indication | 84849002 | |
Pruritus ani | indication | 90446007 | |
Eruption of skin | indication | 271807003 | DOID:0050486 |
Skin irritation | indication | 367466007 | |
Tinea cruris | indication | 399029005 | |
Allergic otitis externa | indication | 405821001 | |
Arthropod bite wound | indication | 409985002 | |
Itching of skin | indication | 418363000 | |
Itching of ear | indication | 699392007 | |
Inflammatory dermatosis | indication | 703938007 | |
Prevent Minor Bacterial Skin Infection | indication | ||
Minor Skin Wound Pain | indication | ||
Minor Bacterial Skin Infections | indication | ||
Mycosis | contraindication | 3218000 | DOID:1564 |
Measles | contraindication | 14189004 | DOID:8622 |
Herpes zoster auricularis | contraindication | 21954000 | DOID:9210 |
Abscess of intestine | contraindication | 24557004 | |
Acute tuberculosis | contraindication | 25629007 | |
Hyperthyroidism | contraindication | 34486009 | DOID:7998 |
Gastrointestinal fistula | contraindication | 37831005 | |
Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
Contact dermatitis | contraindication | 40275004 | DOID:2773 |
Infectious disease | contraindication | 40733004 | |
Hypothyroidism | contraindication | 40930008 | DOID:1459 |
Conduction disorder of the heart | contraindication | 44808001 | |
Skin ulcer | contraindication | 46742003 | |
Chronic heart failure | contraindication | 48447003 | |
Anxiety | contraindication | 48694002 | |
Perforation of tympanic membrane | contraindication | 60442001 | |
Osteoporosis | contraindication | 64859006 | DOID:11476 |
Psychotic disorder | contraindication | 69322001 | |
Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
Third degree burn injury | contraindication | 80247002 | |
Open-angle glaucoma | contraindication | 84494001 | DOID:1067 |
Herpes simplex | contraindication | 88594005 | DOID:8566 |
Kidney disease | contraindication | 90708001 | DOID:557 |
Fissure in skin | contraindication | 95321009 | |
Open wound | contraindication | 125643001 | |
Tuberculosis of ear | contraindication | 186269001 | |
Ophthalmic herpes simplex | contraindication | 186542001 | |
Anastomosis of intestine | contraindication | 235407009 | |
Telangiectasia disorder | contraindication | 247479008 | |
Benign prostatic hyperplasia | contraindication | 266569009 | |
Diverticulitis of gastrointestinal tract | contraindication | 271366000 | |
Varicella-zoster virus infection | contraindication | 309465005 | |
Viral ear infection | contraindication | 312137007 | |
Fungal ear infection | contraindication | 312148000 | |
Adrenal cortical hypofunction | contraindication | 386584007 | DOID:10493 |
Atrophoderma | contraindication | 399979006 | |
Peripheral vascular disease | contraindication | 400047006 | |
Disorder of coronary artery | contraindication | 414024009 | |
Denuded skin | contraindication | 418242004 | |
Nervousness | contraindication |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 7.65 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Sigma non-opioid intracellular receptor 1 | Membrane receptor | Ki | 7.29 | DRUG MATRIX | |||||
Sodium channel alpha subunits; brain (Types I, II, III) | Ion channel | IC50 | 4.67 | CHEMBL | |||||
Membrane-associated progesterone receptor component 1 | Membrane receptor | Ki | 6.20 | DRUG MATRIX |
ID | Source |
---|---|
4018983 | VUID |
N0000171570 | NUI |
D00739 | KEGG_DRUG |
637-58-1 | SECONDARY_CAS_RN |
4018197 | VANDF |
4018983 | VANDF |
C0071810 | UMLSCUI |
CHEBI:8357 | CHEBI |
PX9 | PDB_CHEM_ID |
CHEMBL1198 | ChEMBL_ID |
CHEMBL1201171 | ChEMBL_ID |
DB09345 | DRUGBANK_ID |
C005548 | MESH_SUPPLEMENTAL_RECORD_UI |
068X84E056 | UNII |
4886 | PUBCHEM_CID |
34347 | RXNORM |
5341 | MMSL |
5342 | MMSL |
72272 | MMSL |
001359 | NDDF |
004571 | NDDF |
31872002 | SNOMEDCT_US |
387175007 | SNOMEDCT_US |
387284004 | SNOMEDCT_US |
235 | INN_ID |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
PROCTOFOAMHC | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0037-6822 | AEROSOL, FOAM | 100 mg | TOPICAL | ANDA | 22 sections |
PROCTOFOAMNS | HUMAN OTC DRUG LABEL | 1 | 0037-6823 | AEROSOL, FOAM | 150 mg | RECTAL | OTC monograph final | 11 sections |
EPIFOAM | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0037-6824 | AEROSOL, FOAM | 100 mg | TOPICAL | ANDA | 20 sections |
Good Sense Triple Antibioticand Pain Relief | HUMAN OTC DRUG LABEL | 4 | 0113-0679 | OINTMENT | 10 mg | TOPICAL | OTC monograph final | 13 sections |
Good Sense HemorrhoidalMaximum Strength Pain Relief | HUMAN OTC DRUG LABEL | 4 | 0113-0944 | CREAM | 1 g | TOPICAL | OTC monograph final | 15 sections |
good sense triple antibiotic | HUMAN OTC DRUG LABEL | 4 | 0113-1140 | OINTMENT | 10 mg | TOPICAL | OTC monograph final | 13 sections |
Basic Care First Aid Antibiotic Plus Pain Relief | HUMAN OTC DRUG LABEL | 4 | 0113-7679 | OINTMENT | 10 mg | TOPICAL | OTC monograph final | 13 sections |
Caladryl | HUMAN OTC DRUG LABEL | 3 | 0187-5465 | LOTION | 10 mg | TOPICAL | OTC monograph final | 14 sections |
Caladryl Clear | HUMAN OTC DRUG LABEL | 2 | 0187-5466 | LOTION | 10 mg | TOPICAL | OTC monograph final | 14 sections |
ITCH X | HUMAN OTC DRUG LABEL | 2 | 0225-0495 | GEL | 1 g | TOPICAL | OTC monograph not final | 14 sections |
ITCH-X | HUMAN OTC DRUG LABEL | 2 | 0225-0516 | SPRAY | 1 g | TOPICAL | OTC monograph not final | 13 sections |
Sarna | HUMAN OTC DRUG LABEL | 1 | 0316-0230 | LOTION | 10 mg | TOPICAL | OTC monograph not final | 13 sections |
Triple Antibiotic with Pain ReliefMaximum Strength | HUMAN OTC DRUG LABEL | 4 | 0363-0123 | OINTMENT | 10 mg | TOPICAL | OTC MONOGRAPH FINAL | 13 sections |
Walgreen Anti-Itch | HUMAN OTC DRUG LABEL | 1 | 0363-0263 | LOTION | 1 g | TOPICAL | OTC monograph not final | 13 sections |
Hemorrhoidal Cream | HUMAN OTC DRUG LABEL | 4 | 0363-0641 | CREAM | 1 g | TOPICAL | OTC monograph not final | 15 sections |
Hemorrhoidal Cream | HUMAN OTC DRUG LABEL | 4 | 0363-0641 | CREAM | 1 g | TOPICAL | OTC monograph not final | 15 sections |
First Aid Antibiotic | HUMAN OTC DRUG LABEL | 4 | 0363-0841 | OINTMENT | 10 mg | TOPICAL | OTC monograph final | 13 sections |
Walgreens Maximum Strength Hemorrhoidal | HUMAN OTC DRUG LABEL | 4 | 0363-1760 | CREAM | 0.01 mg | TOPICAL | OTC monograph final | 13 sections |
Walgreens Multi-Antibiotic with Pain Relief Cream | HUMAN OTC DRUG LABEL | 3 | 0363-2123 | CREAM | 10 mg | TOPICAL | OTC monograph not final | 9 sections |
Triple Antibiotic | HUMAN OTC DRUG LABEL | 4 | 0363-2900 | OINTMENT | 10 mg | TOPICAL | OTC monograph final | 13 sections |
MEDICATED ANTI-ITCHWell at Walgreens | HUMAN OTC DRUG LABEL | 2 | 0363-3231 | CREAM | 1 g | TOPICAL | OTC monograph not final | 12 sections |
Walgreens Maximum Strength Triple Antibiotic With Pain Relief | HUMAN OTC DRUG LABEL | 4 | 0363-7872 | OINTMENT | 10 mg | TOPICAL | OTC monograph final | 11 sections |
Calamine Plus Pramoxine HCl | HUMAN OTC DRUG LABEL | 3 | 0363-8588 | AEROSOL, SPRAY | 2.72 mg | TOPICAL | OTC monograph not final | 12 sections |
Triple Antibiotic Plus Pain Relief | HUMAN OTC DRUG LABEL | 4 | 0363-8888 | OINTMENT | 10 mg | TOPICAL | OTC MONOGRAPH FINAL | 14 sections |
Calamine | HUMAN OTC DRUG LABEL | 3 | 0363-9114 | LOTION | 10 mg | TOPICAL | OTC monograph final | 12 sections |
Clear Anti-Itch | HUMAN OTC DRUG LABEL | 2 | 0363-9115 | LOTION | 1 mg | TOPICAL | OTC monograph final | 12 sections |
Clear Anti-Itch | HUMAN OTC DRUG LABEL | 2 | 0363-9115 | LOTION | 1 mg | TOPICAL | OTC monograph final | 12 sections |
Ivy Wash | HUMAN OTC DRUG LABEL | 1 | 0395-0119 | LOTION | 10 1 | TOPICAL | OTC monograph not final | 13 sections |
Humco Calaclear | HUMAN OTC DRUG LABEL | 2 | 0395-0400 | LOTION | 10 mg | TOPICAL | OTC monograph final | 12 sections |
Humco Calaclear | HUMAN OTC DRUG LABEL | 2 | 0395-0400 | LOTION | 10 mg | TOPICAL | OTC monograph final | 12 sections |