pramocaine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
local anaesthetics 3487 140-65-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • pramocaine hydrochloride
  • pramoxine
  • pramoxine hydrochloride
  • pramocain
  • pramocaine
  • pramoxin
  • pramoxine HCl
  • Molecular weight: 293.41
  • Formula: C17H27NO3
  • CLOGP: 4.16
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 0
  • TPSA: 30.93
  • ALOGS: -3.12
  • ROTB: 9

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
Aug. 13, 1976 FDA SEBELA IRELAND LTD

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Macular degeneration 211.45 16.87 67 4570 12294 53332135
Salpingo-oophorectomy unilateral 114.76 16.87 23 4614 643 53343786
Sinusitis fungal 92.55 16.87 22 4615 1376 53343053
Sputum increased 86.94 16.87 23 4614 2223 53342206
Respiratory symptom 83.18 16.87 23 4614 2626 53341803
Nasal polyps 80.53 16.87 23 4614 2953 53341476
Embolism venous 80.36 16.87 23 4614 2976 53341453
Female genital tract fistula 77.70 16.87 24 4613 4034 53340395
Diastolic dysfunction 69.10 16.87 24 4613 5820 53338609
Chronic sinusitis 64.87 16.87 23 4614 5922 53338507
Hysterectomy 56.71 16.87 23 4614 8538 53335891
Emphysema 56.66 16.87 24 4613 9935 53334494
Faecal volume decreased 53.23 16.87 10 4627 197 53344232
Diverticulum 49.65 16.87 23 4614 11756 53332673
Eczema 46.68 16.87 28 4609 24154 53320275
Tricuspid valve incompetence 45.26 16.87 23 4614 14373 53330056
Iron deficiency anaemia 45.16 16.87 25 4612 18555 53325874
Hiatus hernia 43.89 16.87 25 4612 19595 53324834
Obstructive airways disorder 41.13 16.87 23 4614 17406 53327023
Sleep apnoea syndrome 39.83 16.87 26 4611 25976 53318453
Disease recurrence 39.77 16.87 24 4613 20922 53323507
Fungal infection 39.32 16.87 28 4609 32218 53312211
Candida infection 38.05 16.87 25 4612 25248 53319181
Nail infection 34.11 16.87 11 4626 2123 53342306
Dyspnoea exertional 33.70 16.87 32 4605 54968 53289461
Deep vein thrombosis 32.49 16.87 38 4599 82875 53261554
Mucous stools 30.34 16.87 11 4626 3015 53341414
Haematochezia 24.72 16.87 24 4613 42334 53302095
Osteoporosis 24.66 16.87 25 4612 46435 53297994
Pulmonary embolism 22.96 16.87 38 4599 114404 53230025
Jarisch-Herxheimer reaction 21.10 16.87 5 4632 308 53344121
Oedema peripheral 20.98 16.87 46 4591 170741 53173688
Chest discomfort 19.86 16.87 33 4604 99662 53244767
Wheezing 19.30 16.87 26 4611 65249 53279180
Dermatophytosis 18.56 16.87 4 4633 160 53344269

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event

Pharmacologic Action:

SourceCodeDescription
ATC C05AD07 CARDIOVASCULAR SYSTEM
VASOPROTECTIVES
AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
Local anesthetics
ATC D04AB07 DERMATOLOGICALS
ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
Anesthetics for topical use
MeSH PA D000777 Anesthetics
MeSH PA D000779 Anesthetics, Local
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D018689 Sensory System Agents
CHEBI has role CHEBI:36333 local anaesthetics

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Otitis externa indication 3135009
Proctitis indication 3951002 DOID:3127
Tinea pedis indication 6020002 DOID:12403
Wound indication 13924000
Dry skin indication 16386004
Burn injury indication 48333001
Hemorrhoids indication 70153002 DOID:9746
Rectal pain indication 77880009
Tinea corporis indication 84849002
Pruritus ani indication 90446007
Eruption of skin indication 271807003 DOID:0050486
Skin irritation indication 367466007
Tinea cruris indication 399029005
Allergic otitis externa indication 405821001
Arthropod bite wound indication 409985002
Itching of skin indication 418363000
Itching of ear indication 699392007
Inflammatory dermatosis indication 703938007
Prevent Minor Bacterial Skin Infection indication
Minor Skin Wound Pain indication
Minor Bacterial Skin Infections indication
Mycosis contraindication 3218000 DOID:1564
Measles contraindication 14189004 DOID:8622
Herpes zoster auricularis contraindication 21954000 DOID:9210
Abscess of intestine contraindication 24557004
Acute tuberculosis contraindication 25629007
Hyperthyroidism contraindication 34486009 DOID:7998
Gastrointestinal fistula contraindication 37831005
Hypertensive disorder contraindication 38341003 DOID:10763
Contact dermatitis contraindication 40275004 DOID:2773
Infectious disease contraindication 40733004
Hypothyroidism contraindication 40930008 DOID:1459
Conduction disorder of the heart contraindication 44808001
Skin ulcer contraindication 46742003
Chronic heart failure contraindication 48447003
Anxiety contraindication 48694002
Perforation of tympanic membrane contraindication 60442001
Osteoporosis contraindication 64859006 DOID:11476
Psychotic disorder contraindication 69322001
Diabetes mellitus contraindication 73211009 DOID:9351
Third degree burn injury contraindication 80247002
Open-angle glaucoma contraindication 84494001 DOID:1067
Herpes simplex contraindication 88594005 DOID:8566
Kidney disease contraindication 90708001 DOID:557
Fissure in skin contraindication 95321009
Open wound contraindication 125643001
Tuberculosis of ear contraindication 186269001
Ophthalmic herpes simplex contraindication 186542001
Anastomosis of intestine contraindication 235407009
Telangiectasia disorder contraindication 247479008
Benign prostatic hyperplasia contraindication 266569009
Diverticulitis of gastrointestinal tract contraindication 271366000
Varicella-zoster virus infection contraindication 309465005
Viral ear infection contraindication 312137007
Fungal ear infection contraindication 312148000
Adrenal cortical hypofunction contraindication 386584007 DOID:10493
Atrophoderma contraindication 399979006
Peripheral vascular disease contraindication 400047006
Disorder of coronary artery contraindication 414024009
Denuded skin contraindication 418242004
Nervousness contraindication

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 7.65 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Sigma non-opioid intracellular receptor 1 Membrane receptor Ki 7.29 DRUG MATRIX
Sodium channel alpha subunits; brain (Types I, II, III) Ion channel IC50 4.67 CHEMBL
Membrane-associated progesterone receptor component 1 Membrane receptor Ki 6.20 DRUG MATRIX

External reference:

IDSource
4018983 VUID
N0000171570 NUI
D00739 KEGG_DRUG
637-58-1 SECONDARY_CAS_RN
4018197 VANDF
4018983 VANDF
C0071810 UMLSCUI
CHEBI:8357 CHEBI
PX9 PDB_CHEM_ID
CHEMBL1198 ChEMBL_ID
CHEMBL1201171 ChEMBL_ID
DB09345 DRUGBANK_ID
C005548 MESH_SUPPLEMENTAL_RECORD_UI
235 INN_ID
068X84E056 UNII
4886 PUBCHEM_CID
34347 RXNORM
5341 MMSL
5342 MMSL
72272 MMSL
001359 NDDF
004571 NDDF
31872002 SNOMEDCT_US
387175007 SNOMEDCT_US
387284004 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
PROCTOFOAMHC HUMAN PRESCRIPTION DRUG LABEL 2 0037-6822 AEROSOL, FOAM 100 mg TOPICAL ANDA 22 sections
PROCTOFOAMNS HUMAN OTC DRUG LABEL 1 0037-6823 AEROSOL, FOAM 150 mg RECTAL OTC monograph final 11 sections
EPIFOAM HUMAN PRESCRIPTION DRUG LABEL 2 0037-6824 AEROSOL, FOAM 100 mg TOPICAL ANDA 20 sections
Good Sense Triple Antibioticand Pain Relief HUMAN OTC DRUG LABEL 4 0113-0679 OINTMENT 10 mg TOPICAL OTC monograph final 13 sections
Good Sense HemorrhoidalMaximum Strength Pain Relief HUMAN OTC DRUG LABEL 4 0113-0944 CREAM 1 g TOPICAL OTC monograph final 15 sections
good sense triple antibiotic HUMAN OTC DRUG LABEL 4 0113-1140 OINTMENT 10 mg TOPICAL OTC monograph final 13 sections
Basic Care First Aid Antibiotic Plus Pain Relief HUMAN OTC DRUG LABEL 4 0113-7679 OINTMENT 10 mg TOPICAL OTC monograph final 13 sections
Caladryl HUMAN OTC DRUG LABEL 3 0187-5465 LOTION 10 mg TOPICAL OTC monograph final 14 sections
Caladryl Clear HUMAN OTC DRUG LABEL 2 0187-5466 LOTION 10 mg TOPICAL OTC monograph final 14 sections
ITCH X HUMAN OTC DRUG LABEL 2 0225-0495 GEL 1 g TOPICAL OTC monograph not final 14 sections
ITCH-X HUMAN OTC DRUG LABEL 2 0225-0516 SPRAY 1 g TOPICAL OTC monograph not final 13 sections
Sarna HUMAN OTC DRUG LABEL 1 0316-0230 LOTION 10 mg TOPICAL OTC monograph not final 13 sections
Triple Antibiotic with Pain ReliefMaximum Strength HUMAN OTC DRUG LABEL 4 0363-0123 OINTMENT 10 mg TOPICAL OTC MONOGRAPH FINAL 13 sections
Walgreen Anti-Itch HUMAN OTC DRUG LABEL 1 0363-0263 LOTION 1 g TOPICAL OTC monograph not final 13 sections
Hemorrhoidal Cream HUMAN OTC DRUG LABEL 4 0363-0641 CREAM 1 g TOPICAL OTC monograph not final 15 sections
Hemorrhoidal Cream HUMAN OTC DRUG LABEL 4 0363-0641 CREAM 1 g TOPICAL OTC monograph not final 15 sections
First Aid Antibiotic HUMAN OTC DRUG LABEL 4 0363-0841 OINTMENT 10 mg TOPICAL OTC monograph final 13 sections
Walgreens Maximum Strength Hemorrhoidal HUMAN OTC DRUG LABEL 4 0363-1760 CREAM 0.01 mg TOPICAL OTC monograph final 13 sections
Walgreens Multi-Antibiotic with Pain Relief Cream HUMAN OTC DRUG LABEL 3 0363-2123 CREAM 10 mg TOPICAL OTC monograph not final 9 sections
Triple Antibiotic HUMAN OTC DRUG LABEL 4 0363-2900 OINTMENT 10 mg TOPICAL OTC monograph final 13 sections
MEDICATED ANTI-ITCHWell at Walgreens HUMAN OTC DRUG LABEL 2 0363-3231 CREAM 1 g TOPICAL OTC monograph not final 12 sections
Walgreens Maximum Strength Triple Antibiotic With Pain Relief HUMAN OTC DRUG LABEL 4 0363-7872 OINTMENT 10 mg TOPICAL OTC monograph final 11 sections
Calamine Plus Pramoxine HCl HUMAN OTC DRUG LABEL 3 0363-8588 AEROSOL, SPRAY 2.72 mg TOPICAL OTC monograph not final 12 sections
Triple Antibiotic Plus Pain Relief HUMAN OTC DRUG LABEL 4 0363-8888 OINTMENT 10 mg TOPICAL OTC MONOGRAPH FINAL 14 sections
Calamine HUMAN OTC DRUG LABEL 3 0363-9114 LOTION 10 mg TOPICAL OTC monograph final 12 sections
Clear Anti-Itch HUMAN OTC DRUG LABEL 2 0363-9115 LOTION 1 mg TOPICAL OTC monograph final 12 sections
Ivy Wash HUMAN OTC DRUG LABEL 1 0395-0119 LOTION 10 1 TOPICAL OTC monograph not final 13 sections
Humco Calaclear HUMAN OTC DRUG LABEL 2 0395-0400 LOTION 10 mg TOPICAL OTC monograph final 12 sections
Humco Calagesic HUMAN OTC DRUG LABEL 2 0395-0420 LOTION 10 mg TOPICAL OTC monograph final 11 sections
Calaclear HUMAN OTC DRUG LABEL 2 0395-9108 LOTION 10 mg TOPICAL OTC monograph final 12 sections