etidocaine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
local anaesthetics 1097 36637-18-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • etidocaine
  • etidocaine hydrochloride
  • etidocaine HCl
A local anesthetic with rapid onset and long action, similar to BUPIVACAINE.
  • Molecular weight: 276.42
  • Formula: C17H28N2O
  • CLOGP: 3.32
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 1
  • TPSA: 32.34
  • ALOGS: -3.16
  • ROTB: 7

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

PropertyValueReference
MRTD (Maximum Recommended Therapeutic Daily Dose) 24.13 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 0 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

DateAgencyCompanyOrphan
Aug. 30, 1976 FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC N01BB07 NERVOUS SYSTEM
ANESTHETICS
ANESTHETICS, LOCAL
Amides
ATC N01BB57 NERVOUS SYSTEM
ANESTHETICS
ANESTHETICS, LOCAL
Amides
CHEBI has role CHEBI:36333 local anesthetics
MeSH PA D000777 Anesthetics
MeSH PA D000779 Anesthetics, Local
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D018689 Sensory System Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Sinus tachycardia contraindication 11092001
Myocardial infarction contraindication 22298006 DOID:5844
Parkinsonism contraindication 32798002
Hyperthyroidism contraindication 34486009 DOID:7998
Hypertensive disorder contraindication 38341003 DOID:10763
Conduction disorder of the heart contraindication 44808001
Cerebral arteriosclerosis contraindication 65312002
Diabetes mellitus contraindication 73211009 DOID:9351
Cardiogenic shock contraindication 89138009
Bleeding contraindication 131148009
Angina pectoris contraindication 194828000
Primary dilated cardiomyopathy contraindication 195021004
Angle-closure glaucoma contraindication 392291006 DOID:13550
Disorder of coronary artery contraindication 414024009

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 13.24 acidic
pKa2 7.84 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Sodium channel protein type 4 subunit alpha Ion channel BLOCKER WOMBAT-PK CHEMBL
Sodium channel protein type 2 subunit alpha Ion channel BLOCKER UNKNOWN CHEMBL
Sodium channel protein type 5 subunit alpha Ion channel BLOCKER WOMBAT-PK CHEMBL
Sodium channel protein type 2 subunit alpha Ion channel BLOCKER IC50 6 IUPHAR

External reference:

IDSource
4019752 VUID
N0000147843 NUI
D04095 KEGG_DRUG
36637-19-1 SECONDARY_CAS_RN
4018912 VANDF
4019752 VANDF
C0015120 UMLSCUI
CHEBI:4904 CHEBI
CHEMBL492 ChEMBL_ID
CHEMBL1200597 ChEMBL_ID
DB08987 DRUGBANK_ID
D005041 MESH_DESCRIPTOR_UI
37497 PUBCHEM_CID
2621 IUPHAR_LIGAND_ID
3419 INN_ID
I6CQM0F31V UNII
227221 RXNORM
4705 MMSL
d01400 MMSL
001339 NDDF
005119 NDDF
370282009 SNOMEDCT_US
4043008 SNOMEDCT_US
88485001 SNOMEDCT_US

Pharmaceutical products:

None