benzocaine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
local anaesthetics 323 94-09-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • benzocaine
  • norcaine
  • 4-Carbethoxyaniline
  • benzocaine hydrobromide
  • benzocaine hydrochloride
  • benzocaine HCl
  • benzocaine methanesulfonate
  • ethyl aminobenzoate
  • parathesin
  • americaine
  • benzocaine formate
A surface anesthetic that acts by preventing transmission of impulses along NERVE FIBERS and at NERVE ENDINGS.
  • Molecular weight: 165.19
  • Formula: C9H11NO2
  • CLOGP: 1.92
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 1
  • TPSA: 52.32
  • ALOGS: -1.76
  • ROTB: 3

Drug dosage:

None

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 1.605 High 1
caco2-efflux Caco-2 efflux ratio (BA/AB) 0.240 High 1
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 66.988 10^-6 cm/s High 1
dh-clint Dog hepatocyte intrinsic clearance 280.543 uL/min/10^6 cells High 1
dppb Dog plasma protein binding (% unbound) 54.590 % High 1
fcs-ppb Fetal calf serum protein binding (% unbound) 47.350 % High 1
herg hERG pIC50 3.995 pIC50 High 1
hh-clint Human hepatocyte intrinsic clearance 746.449 uL/min/10^6 cells High 1
hlm-clint Human liver microsomal intrinsic clearance 189.234 uL/min/mg protein High 1
hppb Human plasma protein binding (% unbound) 34.630 % High 1
kinase-safety-class ACVR2A,ACVR2B,AKT2,AKT3,ALK,AURKA,AURKB,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,CHEK1,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GRK3,GSK3B,ITK,JAK1,JAK2,MAP2K6,MAP3K1,MAP3K21,MAP3K7,MAPK1,MAPK10,MAPK12,MAPK7,MAPK9,MARK4,MET,MTOR,NTRK2,PAK4,PDK1,PDK2,PDK4,PDPK1,PIK3CB,PIM2,PRKCD,PRKDC,SGK1,SIK2,SIK3,STK33,SYK,TEK,TTK,ULK1 57
kinase-selectivity-class ACVR2A,AURKA,AXL,DDR1,DYRK1B,GRK2,MAP2K6,MAPK7,MARK4,SIK2,STK33,TEK,TTK 13
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 0.716 High 1
mh-clint Mouse hepatocyte intrinsic clearance 696.627 High 1
mppb Mouse plasma protein binding (% unbound) 54.880 High 1
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 0.376 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pppb Pig plasma protein binding (% unbound) 47.640 % High 1
rh-clint Rat hepatocyte intrinsic clearance 263.633 uL/min/10^6 cells High 1
rh-fuinc Rat hepatocyte fraction unbound in incubation 97.080 % High 1
rppb Rat plasma protein binding (% unbound) 49.650 % High 1
solubility-dd Solubility at pH 7.4 in DMSO 105.925 uM High 1

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Folliculitis 808.46 49.96 1253 136503 203100 90287591
Irritable bowel syndrome 808.20 49.96 1263 136493 206185 90284506
Helicobacter infection 742.91 49.96 1277 136479 225573 90265118
Muscle injury 723.62 49.96 1101 136655 175553 90315138
Injury 721.08 49.96 1167 136589 196182 90294509
Ill-defined disorder 710.73 49.96 1119 136637 183772 90306919
Impaired healing 700.49 49.96 1267 136489 232932 90257759
Duodenal ulcer perforation 642.48 49.96 1182 136574 220106 90270585
Rheumatic fever 622.22 49.96 951 136805 152170 90338521
Type 2 diabetes mellitus 599.24 49.96 1093 136663 202151 90288540
Pericarditis 563.69 49.96 1258 136498 268893 90221798
Joint range of motion decreased 563.13 49.96 851 136905 134792 90355899
Sleep disorder 557.42 49.96 1044 136712 196986 90293705
Hand deformity 543.72 49.96 1312 136444 295050 90195641
Sleep disorder due to general medical condition, insomnia type 488.79 49.96 775 136981 127919 90362772
Glossodynia 484.13 49.96 1322 136434 320457 90170234
Cough 482.00 49.96 18 137738 368944 90121747
Swollen joint count increased 474.76 49.96 707 137049 110499 90380192
Pemphigus 459.32 49.96 1310 136446 325554 90165137
Wound 451.95 49.96 1241 136515 301739 90188952
Blister 443.16 49.96 1106 136650 253892 90236799
Lower respiratory tract infection 441.73 49.96 1093 136663 249566 90241125
Liver injury 441.46 49.96 868 136888 169699 90320992
Hypercholesterolaemia 437.21 49.96 646 137110 100246 90390445
Fibromyalgia 436.09 49.96 966 136790 205303 90285388
C-reactive protein abnormal 433.28 49.96 730 137026 126699 90363992
Anti-cyclic citrullinated peptide antibody positive 430.45 49.96 1044 136712 235389 90255302
Anaemia 426.53 49.96 28 137728 352774 90137917
Psoriatic arthropathy 423.99 49.96 1016 136740 227319 90263372
Product dose omission issue 421.24 49.96 4 137752 291683 90199008
Acute kidney injury 420.60 49.96 15 137741 320372 90170319
Facet joint syndrome 416.33 49.96 623 137133 97766 90392925
Dislocation of vertebra 415.53 49.96 468 137288 55500 90435191
Adjustment disorder with depressed mood 413.60 49.96 470 137286 56283 90434408
Rheumatoid factor positive 406.63 49.96 842 136914 170808 90319883
Lip dry 401.37 49.96 621 137135 100334 90390357
Lupus vulgaris 389.02 49.96 408 137348 44651 90446040
Grip strength decreased 385.70 49.96 582 137174 91994 90398697
Stomatitis 380.90 49.96 1096 136660 273602 90217089
Wound infection 375.64 49.96 620 137136 105782 90384909
Hypotension 367.68 49.96 35 137721 325362 90165329
Urinary tract infection 367.21 49.96 25 137731 305607 90185084
Synovitis 351.51 49.96 1201 136555 328551 90162140
Deep vein thrombosis postoperative 348.78 49.96 482 137274 70327 90420364
Systemic lupus erythematosus 346.27 49.96 1272 136484 360624 90130067
Constipation 345.62 49.96 20 137736 280375 90210316
Blood cholesterol increased 334.01 49.96 876 136880 207136 90283555
Hepatic enzyme increased 331.83 49.96 1252 136504 359484 90131207
Discomfort 330.71 49.96 1042 136714 273293 90217398
Drug interaction 328.08 49.96 24 137732 276429 90214262
Road traffic accident 327.22 49.96 587 137169 107039 90383652
Breast cancer stage III 321.09 49.96 509 137247 83938 90406753
Pulmonary fibrosis 302.42 49.96 567 137189 106936 90383755
Gait inability 298.23 49.96 676 137080 145780 90344911
Neutropenia 296.94 49.96 10 137746 224894 90265797
Mobility decreased 295.41 49.96 945 136811 249789 90240902
Drug ineffective 293.08 49.96 1102 136654 1383196 89107495
X-ray abnormal 289.07 49.96 351 137405 45073 90445618
Wheezing 285.65 49.96 903 136853 237177 90253514
Fall 284.38 49.96 192 137564 481618 90009073
Lower limb fracture 280.87 49.96 481 137275 84532 90406159
Gastrointestinal disorder 280.47 49.96 943 136813 255744 90234947
Infection 279.48 49.96 1190 136566 360904 90129787
Dehydration 279.10 49.96 3 137753 194444 90296247
Contusion 274.56 49.96 923 136833 250293 90240398
Autoimmune disorder 273.23 49.96 449 137307 76295 90414396
Liver disorder 273.21 49.96 583 137173 120686 90370005
Back pain 270.03 49.96 74 137682 317101 90173590
Rheumatoid arthritis 267.04 49.96 1175 136581 361439 90129252
Somnolence 263.59 49.96 13 137743 209071 90281620
Infusion related reaction 263.15 49.96 1291 136465 415489 90075202
Arthropathy 260.83 49.96 1175 136581 365067 90125624
Erythema 257.97 49.96 25 137731 229221 90261470
Blood pressure increased 252.72 49.96 11 137745 197206 90293485
Peripheral venous disease 247.76 49.96 452 137304 83469 90407222
Confusional state 244.96 49.96 1198 136558 385007 90105684
Retinitis 236.33 49.96 292 137464 38166 90452525
Oedema 235.89 49.96 755 137001 199540 90291151
Injection site pain 228.29 49.96 8 137748 173691 90317000
Anti-cyclic citrullinated peptide antibody 226.95 49.96 242 137514 26979 90463712
General physical health deterioration 225.46 49.96 1102 136654 354013 90136678
Bursitis 225.16 49.96 568 137188 131086 90359605
Death 224.36 49.96 218 137538 456333 90034358
Walking aid user 223.69 49.96 273 137483 35233 90455458
Sciatica 223.28 49.96 483 137273 100899 90389792
Prescribed overdose 214.87 49.96 465 137291 97160 90393531
Porphyria acute 213.69 49.96 194 137562 17781 90472910
Bone erosion 213.20 49.96 328 137428 52693 90437998
Swelling 213.03 49.96 1223 136533 417835 90072856
Dyspepsia 208.42 49.96 719 137037 197441 90293250
Sepsis 203.90 49.96 19 137737 179795 90310896
Obesity 203.68 49.96 477 137279 105030 90385661
Disease progression 203.10 49.96 8 137748 156607 90334084
Delirium 201.67 49.96 472 137284 103887 90386804
Exostosis 201.54 49.96 320 137436 52814 90437877
Lupus-like syndrome 200.38 49.96 305 137451 48541 90442150
Night sweats 197.10 49.96 533 137223 128233 90362458
Musculoskeletal stiffness 193.73 49.96 928 136828 295604 90195087
Joint swelling 192.85 49.96 1367 136389 501933 89988758
Ulcer haemorrhage 191.72 49.96 218 137538 26103 90464588
Feeling abnormal 191.42 49.96 17 137739 167218 90323473
Amnesia 190.62 49.96 473 137283 108032 90382659
Urticaria 190.26 49.96 959 136797 311775 90178916
COVID-19 188.39 49.96 19 137737 168824 90321867
Musculoskeletal pain 187.64 49.96 630 137126 170621 90320070
Nausea 187.45 49.96 961 136795 1109355 89381336
Febrile neutropenia 187.06 49.96 14 137742 158335 90332356
Palpitations 184.34 49.96 5 137751 136723 90353968
Hypersensitivity 184.19 49.96 1252 136504 453425 90037266
Tremor 182.49 49.96 13 137743 153160 90337531
Laryngitis 182.04 49.96 298 137458 50455 90440236
Inflammation 181.71 49.96 641 137115 177951 90312740
Seizure 178.86 49.96 14 137742 152615 90338076
Myalgia 177.61 49.96 27 137729 175098 90315593
Nasopharyngitis 176.95 49.96 1141 136615 405963 90084728
Atrial fibrillation 176.10 49.96 6 137750 133605 90357086
Renal failure 175.85 49.96 5 137751 131002 90359689
Subcutaneous drug absorption impaired 174.53 49.96 153 137603 13392 90477299
Onychomycosis 174.42 49.96 248 137508 37128 90453563
Chills 173.69 49.96 6 137750 131975 90358716
Haemoglobin decreased 173.67 49.96 21 137735 161935 90328756
Hyperhidrosis 173.30 49.96 8 137748 136297 90354394
Hypoaesthesia 172.82 49.96 937 136819 313273 90177418
Neuropathy peripheral 171.07 49.96 9 137747 136961 90353730
Prescribed underdose 170.43 49.96 362 137394 74657 90416034
Hyponatraemia 169.25 49.96 8 137748 133530 90357161
Lung disorder 169.17 49.96 557 137199 149326 90341365
Cerebrovascular accident 168.50 49.96 4 137752 123529 90367162
Syncope 164.80 49.96 9 137747 132654 90358037
Sinusitis 164.32 49.96 986 136770 342102 90148589
Influenza 162.55 49.96 13 137743 139251 90351440
Weight increased 160.46 49.96 1136 136620 416791 90073900
Onychomadesis 159.48 49.96 266 137490 45732 90444959
Chest discomfort 158.52 49.96 14 137742 138351 90352340
White blood cell count decreased 157.98 49.96 31 137725 167078 90323613
Hepatic cirrhosis 156.32 49.96 316 137440 62937 90427754
Dry mouth 155.16 49.96 622 137134 183437 90307254
Pancytopenia 153.08 49.96 7 137749 120256 90370435
Memory impairment 150.92 49.96 647 137109 196597 90294094
General symptom 148.84 49.96 145 137611 14523 90476168
Hip arthroplasty 148.64 49.96 346 137410 75862 90414829
Methaemoglobinaemia 147.65 49.96 86 137670 3929 90486762
Alanine aminotransferase increased 147.08 49.96 8 137748 118330 90372361
Toxicity to various agents 146.49 49.96 133 137623 287713 90202978
Osteoarthritis 145.13 49.96 636 137120 195094 90295597
Disability 144.45 49.96 238 137518 40507 90450184
Platelet count decreased 143.84 49.96 19 137737 136950 90353741
Oropharyngeal pain 142.50 49.96 8 137748 115179 90375512
Diarrhoea 140.18 49.96 846 136910 938344 89552347
Pulmonary embolism 140.16 49.96 17 137739 130803 90359888
Dysphagia 138.28 49.96 8 137748 112270 90378421
Rash vesicular 134.71 49.96 152 137604 18045 90472646
Renal impairment 134.62 49.96 6 137750 105415 90385276
Peripheral swelling 134.35 49.96 1080 136676 412026 90078665
Heart rate increased 133.28 49.96 10 137746 112892 90377799
Balance disorder 132.95 49.96 3 137753 97077 90393614
Vision blurred 132.42 49.96 9 137747 110284 90380407
Pustular psoriasis 132.29 49.96 152 137604 18404 90472287
Myocardial infarction 132.21 49.96 7 137749 105965 90384726
Migraine 131.64 49.96 606 137150 189786 90300905
Cardiac failure 131.27 49.96 9 137747 109487 90381204
Insomnia 130.56 49.96 911 136845 332563 90158128
Herpes zoster 129.32 49.96 3 137753 94641 90396050
Pleural effusion 129.19 49.96 11 137745 111980 90378711
Hypokalaemia 128.93 49.96 22 137734 131094 90359597
Joint stiffness 128.48 49.96 332 137424 77710 90412981
Aspartate aminotransferase increased 127.80 49.96 7 137749 102930 90387761
Joint dislocation 126.35 49.96 236 137520 44346 90446345
Inappropriate schedule of product administration 125.60 49.96 36 137720 149897 90340794
Blood glucose increased 123.02 49.96 5 137751 95241 90395450
Maternal exposure timing unspecified 122.77 49.96 161 137595 22322 90468369
Loss of consciousness 120.60 49.96 32 137724 140206 90350485
C-reactive protein 119.06 49.96 189 137567 31178 90459513
Foot deformity 118.70 49.96 273 137483 59378 90431313
Grip strength 116.97 49.96 102 137654 8863 90481828
Blood creatinine increased 116.83 49.96 10 137746 101376 90389315
Off label use 116.81 49.96 1093 136663 1101159 89389532
Breast cancer stage II 116.74 49.96 200 137556 35134 90455557
Dry skin 115.89 49.96 4 137752 88069 90402622
Gastrointestinal haemorrhage 115.68 49.96 5 137751 90243 90400448
Malignant neoplasm progression 114.21 49.96 14 137742 106856 90383835
Cardiac failure congestive 113.01 49.96 10 137746 98684 90392007
Therapy non-responder 111.99 49.96 458 137298 136246 90354445
Cellulitis 110.99 49.96 7 137749 91330 90399361
Illness 110.47 49.96 3 137753 81966 90408725
Respiratory failure 109.77 49.96 23 137733 118395 90372296
Eye injury 108.20 49.96 107 137649 10913 90479778
Epistaxis 108.18 49.96 5 137751 85120 90405571
Back disorder 107.88 49.96 162 137594 25469 90465222
Flushing 106.88 49.96 7 137749 88484 90402207
Knee arthroplasty 105.58 49.96 322 137434 82860 90407831
Adverse event 103.90 49.96 403 137353 117015 90373676
Myositis 102.26 49.96 153 137603 23975 90466716
Medication error 100.34 49.96 320 137436 84332 90406359
Intentional product use issue 99.69 49.96 617 137139 216275 90274416
Oxygen saturation decreased 99.37 49.96 21 137735 107462 90383229
Therapeutic product effect decreased 99.19 49.96 742 137014 276829 90213862
Septic shock 97.80 49.96 8 137748 84152 90406539
Alopecia 96.87 49.96 1164 136592 493907 89996784
Abdominal discomfort 96.79 49.96 1130 136626 476198 90014493
Ear infection 96.06 49.96 278 137478 69497 90421194
Cataract 95.83 49.96 3 137753 72089 90418602
Rhinorrhoea 95.78 49.96 11 137745 88305 90402386
Wrong technique in product usage process 95.06 49.96 3 137753 71568 90419123
Nasal congestion 94.03 49.96 9 137747 83405 90407286
Contraindicated product administered 93.88 49.96 818 136938 319321 90171370
Nail disorder 93.85 49.96 248 137508 58819 90431872
Electrocardiogram QT prolonged 92.91 49.96 4 137752 72452 90418239
Suicidal ideation 91.75 49.96 5 137751 73850 90416841
Chronic obstructive pulmonary disease 91.71 49.96 5 137751 73824 90416867
Stress 91.18 49.96 9 137747 81386 90409305
Incorrect dose administered 90.36 49.96 8 137748 78922 90411769
C-reactive protein increased 90.36 49.96 527 137229 180862 90309829
Anaphylactic reaction 89.86 49.96 13 137743 87511 90403180
Hypoglycaemia 89.09 49.96 4 137752 69844 90420847
Vertigo 89.04 49.96 4 137752 69807 90420884
Fatigue 88.90 49.96 1229 136527 1152794 89337897
Haematochezia 87.47 49.96 5 137751 70908 90419783
Live birth 85.65 49.96 290 137466 78817 90411874
Hyperkalaemia 85.30 49.96 3 137753 64961 90425730
Burning sensation 83.07 49.96 3 137753 63449 90427242
Deep vein thrombosis 82.47 49.96 19 137737 91601 90399090
Rash erythematous 82.16 49.96 4 137752 65100 90425591
Dyspnoea exertional 80.96 49.96 8 137748 72280 90418411
Gastrointestinal toxicity 80.38 49.96 85 137671 9382 90481309
Skin exfoliation 80.19 49.96 6 137750 67907 90422784
Dysphonia 79.21 49.96 4 137752 63080 90427611
Thrombocytopenia 78.81 49.96 122 137634 208603 90282088
Angioedema 78.74 49.96 5 137751 64871 90425820
Diabetes mellitus 78.73 49.96 5 137751 64870 90425821
Multiple organ dysfunction syndrome 78.03 49.96 7 137749 68329 90422362
Injection site swelling 77.75 49.96 3 137753 59836 90430855
Colitis 77.65 49.96 8 137748 69934 90420757
Neutrophil count decreased 77.34 49.96 9 137747 71523 90419168
Drug-induced liver injury 75.06 49.96 304 137452 90014 90400677
Hypertension 74.80 49.96 1041 136715 456491 90034200
Mucosal inflammation 74.49 49.96 3 137753 57622 90433069
Blood pressure decreased 70.54 49.96 14 137742 74881 90415810
Cardiac arrest 69.97 49.96 36 137720 104899 90385792
Hallucination 69.59 49.96 9 137747 65950 90424741
Productive cough 69.32 49.96 16 137740 77047 90413644
Breast cancer 68.83 49.96 3 137753 53758 90436933
Metabolic acidosis 68.44 49.96 4 137752 55672 90435019
Pulmonary toxicity 68.34 49.96 86 137670 11445 90479246
Blepharospasm 67.90 49.96 212 137544 55233 90435458
Red blood cell sedimentation rate increased 67.83 49.96 277 137479 82318 90408373
Eczema 67.52 49.96 3 137753 52867 90437824
Cardiac disorder 67.22 49.96 5 137751 56867 90433824
Dysgeusia 67.07 49.96 3 137753 52557 90438134
Treatment failure 66.70 49.96 731 137025 303197 90187494
Thrombosis 66.31 49.96 15 137741 73236 90417455
Lethargy 65.70 49.96 9 137747 63130 90427561
Depressed level of consciousness 65.69 49.96 15 137741 72769 90417922
Swollen joint count 65.28 49.96 73 137683 8580 90482111
Hypothyroidism 64.75 49.96 4 137752 53123 90437568
Unevaluable event 64.32 49.96 5 137751 54843 90435848
Headache 64.06 49.96 925 136831 861821 89628870
Dysarthria 63.80 49.96 5 137751 54477 90436214
Drug ineffective for unapproved indication 63.73 49.96 12 137744 66632 90424059
Swelling face 63.71 49.96 22 137734 81330 90409361
Coma 63.53 49.96 16 137740 72616 90418075
Asthenia 63.03 49.96 514 137242 533237 89957454
Rhabdomyolysis 62.05 49.96 4 137752 51252 90439439
Liver function test increased 61.51 49.96 274 137482 84581 90406110
Suicide attempt 61.50 49.96 19 137737 75380 90415311
Drug tolerance decreased 60.58 49.96 144 137612 31986 90458705
Chronic kidney disease 60.52 49.96 4 137752 50187 90440504
Finger deformity 60.48 49.96 146 137610 32751 90457940
Adverse reaction 60.22 49.96 137 137619 29575 90461116
Ascites 60.03 49.96 3 137753 47737 90442954
International normalised ratio increased 59.41 49.96 3 137753 47313 90443378
Back injury 58.70 49.96 180 137576 46442 90444249
Blood alkaline phosphatase increased 57.48 49.96 4 137752 48075 90442616
Blood potassium decreased 56.97 49.96 4 137752 47723 90442968
Speech disorder 56.89 49.96 3 137753 45582 90445109
Encephalopathy 55.13 49.96 4 137752 46440 90444251
Haemorrhage 53.91 49.96 19 137737 69350 90421341
Sleep disorder due to a general medical condition 53.80 49.96 170 137586 44568 90446123
Seronegative arthritis 53.50 49.96 98 137658 18136 90472555
Agitation 52.79 49.96 18 137738 67080 90423611
Arrhythmia 52.16 49.96 3 137753 42329 90448362
Colitis ulcerative 51.78 49.96 205 137551 60061 90430630
Gastritis 51.32 49.96 3 137753 41750 90448941
Hypoxia 51.07 49.96 23 137733 72376 90418315
Frequent bowel movements 50.81 49.96 196 137560 56739 90433952
Pulmonary oedema 49.99 49.96 16 137740 62064 90428627

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug abuse 275.95 20.12 152 3866 104619 42512698
Methaemoglobinaemia 266.25 20.12 69 3949 5705 42611612
Toxicity to various agents 164.37 20.12 150 3868 228986 42388331
Intentional product misuse 146.62 20.12 84 3934 61816 42555501
Serotonin syndrome 106.84 20.12 51 3967 25794 42591523
Completed suicide 86.56 20.12 72 3946 96393 42520924
Respiratory arrest 73.71 20.12 41 3977 28383 42588934
Intentional overdose 51.53 20.12 41 3977 51415 42565902
Hangover 44.73 20.12 12 4006 1126 42616191
Overdose 37.77 20.12 48 3970 105216 42512101
Mydriasis 35.26 20.12 17 4001 8753 42608564
Cardiac arrest 33.28 20.12 46 3972 109274 42508043
Cardio-respiratory arrest 29.81 20.12 32 3986 58604 42558713
Paranoia 22.78 20.12 15 4003 14011 42603306

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Irritable bowel syndrome 775.06 36.65 882 108511 163333 110316573
Ill-defined disorder 761.61 36.65 855 108538 155998 110323908
Folliculitis 756.81 36.65 880 108513 166773 110313133
Helicobacter infection 742.58 36.65 907 108486 180970 110298936
Rheumatic fever 732.41 36.65 746 108647 121833 110358073
Muscle injury 675.74 36.65 763 108630 140044 110339862
Type 2 diabetes mellitus 669.26 36.65 850 108543 176382 110303524
Hand deformity 667.69 36.65 945 108448 217561 110262345
Glossodynia 663.46 36.65 950 108443 221054 110258852
Duodenal ulcer perforation 643.88 36.65 835 108558 176865 110303041
Facet joint syndrome 638.74 36.65 622 108771 96206 110383700
Pemphigus 626.24 36.65 908 108485 213662 110266244
Injury 625.23 36.65 822 108571 176443 110303463
Lip dry 625.06 36.65 624 108769 99459 110380447
Impaired healing 619.10 36.65 863 108530 195854 110284052
Joint range of motion decreased 615.10 36.65 678 108715 121154 110358752
Systemic lupus erythematosus 595.69 36.65 972 108421 253366 110226540
C-reactive protein abnormal 593.84 36.65 686 108707 129009 110350897
Wound 588.83 36.65 925 108468 233512 110246394
Pericarditis 577.46 36.65 884 108509 218230 110261676
Sleep disorder 574.35 36.65 837 108556 197807 110282099
Sleep disorder due to general medical condition, insomnia type 543.79 36.65 594 108799 105049 110374857
Psoriatic arthropathy 528.53 36.65 801 108592 195960 110283946
Fibromyalgia 514.22 36.65 734 108659 170175 110309731
Rheumatoid factor positive 504.09 36.65 636 108757 131004 110348902
Acute kidney injury 482.74 36.65 39 109354 635391 109844515
Swollen joint count increased 481.11 36.65 499 108894 83162 110396744
Synovitis 461.24 36.65 907 108486 273185 110206721
Breast cancer stage III 437.22 36.65 462 108931 78655 110401251
Liver injury 429.07 36.65 630 108763 149783 110330123
Anti-cyclic citrullinated peptide antibody positive 426.44 36.65 696 108697 181288 110298618
Lower respiratory tract infection 425.44 36.65 818 108575 242288 110237618
Stomatitis 402.15 36.65 850 108543 269392 110210514
Road traffic accident 400.19 36.65 512 108881 106886 110373020
Blister 400.19 36.65 767 108626 226609 110253297
Peripheral venous disease 400.17 36.65 454 108939 83663 110396243
Bursitis 395.11 36.65 561 108832 129357 110350549
Anaemia 392.96 36.65 42 109351 547044 109932862
Deep vein thrombosis postoperative 383.58 36.65 377 109016 58914 110420992
Rheumatoid arthritis 375.65 36.65 880 108513 298733 110181173
Hypercholesterolaemia 365.42 36.65 450 108943 90387 110389519
Dislocation of vertebra 360.04 36.65 318 109075 43403 110436503
Mobility decreased 358.07 36.65 751 108642 236671 110243235
Adjustment disorder with depressed mood 357.03 36.65 317 109076 43566 110436340
Lower limb fracture 353.86 36.65 404 108989 74944 110404962
Night sweats 351.85 36.65 540 108853 133443 110346463
Lupus vulgaris 350.29 36.65 281 109112 33602 110446304
Grip strength decreased 346.67 36.65 412 108981 79762 110400144
Swelling 345.96 36.65 941 108452 350100 110129806
Wound infection 345.48 36.65 451 108942 96014 110383892
Discomfort 342.39 36.65 695 108698 214012 110265894
Hepatic enzyme increased 342.37 36.65 886 108507 320006 110159900
X-ray abnormal 339.62 36.65 290 109103 37827 110442079
Hypotension 334.14 36.65 58 109335 523791 109956115
Obesity 332.21 36.65 481 108912 112870 110367036
Inflammation 330.32 36.65 644 108749 192594 110287312
Liver disorder 329.04 36.65 541 108852 141702 110338204
Blood cholesterol increased 325.85 36.65 624 108769 184161 110295745
Cough 322.49 36.65 39 109354 461602 110018304
Sciatica 317.00 36.65 423 108970 91976 110387930
Neutropenia 314.60 36.65 13 109380 374607 110105299
Drug interaction 309.05 36.65 60 109333 500123 109979783
Musculoskeletal pain 297.17 36.65 597 108796 182426 110297480
Arthropathy 294.49 36.65 782 108611 286740 110193166
Porphyria acute 291.63 36.65 199 109194 18581 110461325
Autoimmune disorder 288.85 36.65 340 109053 65143 110414763
Dry mouth 285.83 36.65 619 108774 199329 110280577
Product dose omission issue 281.27 36.65 8 109385 321774 110158132
Infusion related reaction 278.16 36.65 919 108474 380243 110099663
Methaemoglobinaemia 274.43 36.65 148 109245 9020 110470886
Gait inability 273.64 36.65 487 108906 135889 110344017
Onychomycosis 268.00 36.65 255 109138 38276 110441630
Lung disorder 266.07 36.65 565 108828 179482 110300424
Wheezing 261.13 36.65 694 108699 254536 110225370
Onychomadesis 259.96 36.65 271 109122 45392 110434514
Constipation 252.85 36.65 29 109364 357757 110122149
Gastrointestinal disorder 251.68 36.65 662 108731 241290 110238616
Urinary tract infection 250.36 36.65 19 109374 326263 110153643
Retinitis 244.19 36.65 224 109169 32103 110447803
Osteoarthritis 243.63 36.65 550 108843 182073 110297833
Pulmonary fibrosis 238.46 36.65 390 109003 101652 110378254
Bone erosion 223.38 36.65 252 109141 46119 110433787
Joint swelling 222.34 36.65 947 108446 441898 110038008
Therapeutic product effect decreased 218.88 36.65 633 108760 243683 110236223
Dehydration 218.09 36.65 15 109378 279496 110200410
Lupus-like syndrome 217.83 36.65 234 109159 40558 110439348
Hypoaesthesia 216.18 36.65 743 108650 313480 110166426
Exostosis 213.33 36.65 245 109148 45711 110434195
Sinusitis 213.31 36.65 712 108681 295976 110183930
Prescribed overdose 210.43 36.65 339 109054 87242 110392664
Contusion 208.44 36.65 604 108789 232757 110247149
Sepsis 206.92 36.65 37 109356 327309 110152597
Contraindicated product administered 206.01 36.65 626 108767 247641 110232265
Alopecia 205.15 36.65 808 108585 363945 110115961
Maternal exposure during pregnancy 203.42 36.65 634 108759 254249 110225657
Febrile neutropenia 201.98 36.65 35 109358 316732 110163174
Hypersensitivity 201.25 36.65 862 108531 403136 110076770
Blood pressure increased 201.18 36.65 14 109379 258359 110221547
Somnolence 200.70 36.65 28 109365 297421 110182485
Disease progression 196.66 36.65 11 109382 244023 110235883
Laryngitis 191.66 36.65 223 109170 42188 110437718
Infection 191.42 36.65 787 108606 361413 110118493
Dyspepsia 190.91 36.65 515 108878 190450 110289456
Death 189.97 36.65 248 109145 698621 109781285
Urticaria 188.78 36.65 718 108675 318139 110161767
Musculoskeletal stiffness 188.37 36.65 657 108736 279165 110200741
Migraine 183.87 36.65 475 108918 171177 110308729
C-reactive protein 183.46 36.65 186 109207 30145 110449761
Maternal exposure timing unspecified 183.35 36.65 158 109235 20855 110459051
Erythema 177.69 36.65 36 109357 291411 110188495
Fall 176.79 36.65 202 109191 603280 109876626
Renal failure 174.31 36.65 13 109380 226561 110253345
Anti-cyclic citrullinated peptide antibody 173.96 36.65 150 109243 19814 110460092
Nail disorder 172.79 36.65 248 109145 57687 110422219
Live birth 172.46 36.65 273 109120 69211 110410695
Haemoglobin decreased 168.75 36.65 23 109370 248704 110231202
Back pain 168.57 36.65 78 109315 370918 110108988
Memory impairment 168.42 36.65 502 108891 196442 110283464
Ulcer haemorrhage 167.74 36.65 155 109238 22416 110457490
Atrial fibrillation 166.29 36.65 17 109376 229625 110250281
Insomnia 164.81 36.65 750 108643 359840 110120066
Pancytopenia 164.22 36.65 11 109382 209602 110270304
Grip strength 161.55 36.65 105 109288 9036 110470870
Adverse event 160.11 36.65 341 109052 108468 110371438
Abdominal discomfort 158.09 36.65 789 108604 393069 110086837
Hyponatraemia 157.89 36.65 16 109377 217637 110262269
Oedema 157.16 36.65 511 108882 209465 110270441
Nasopharyngitis 156.87 36.65 788 108605 393573 110086333
Myocardial infarction 156.82 36.65 8 109385 192075 110287831
Weight increased 156.15 36.65 823 108570 418821 110061085
Cerebrovascular accident 153.08 36.65 6 109387 181278 110298628
Syncope 151.95 36.65 13 109380 202523 110277383
Renal impairment 150.27 36.65 9 109384 188436 110291470
Pulmonary embolism 149.92 36.65 18 109375 214456 110265450
Seizure 146.43 36.65 22 109371 221163 110258743
Treatment failure 143.70 36.65 599 108794 276635 110203271
COVID-19 141.82 36.65 34 109359 245026 110234880
Prescribed underdose 140.08 36.65 240 109153 64934 110414972
Drug ineffective 139.47 36.65 908 108485 1519632 108960274
Cardiac failure 138.17 36.65 13 109380 187613 110292293
Medication error 136.72 36.65 314 109079 105052 110374854
Amnesia 136.63 36.65 314 109079 105094 110374812
Myalgia 136.51 36.65 27 109366 222354 110257552
Neuropathy peripheral 135.88 36.65 11 109382 179266 110300640
Chills 135.69 36.65 15 109378 190565 110289341
Injection site pain 134.62 36.65 11 109382 177911 110301995
Alanine aminotransferase increased 132.02 36.65 14 109379 183759 110296147
Blepharospasm 131.29 36.65 212 109181 54639 110425267
Blood creatinine increased 131.21 36.65 14 109379 182875 110297031
Confusional state 130.78 36.65 852 108541 467828 110012078
White blood cell count decreased 130.46 36.65 33 109360 229357 110250549
Platelet count decreased 127.54 36.65 35 109358 230408 110249498
Walking aid user 127.16 36.65 140 109253 24935 110454971
Palpitations 125.75 36.65 8 109385 159204 110320702
Respiratory failure 124.35 36.65 30 109363 215302 110264604
Peripheral swelling 122.95 36.65 751 108642 403283 110076623
General physical health deterioration 122.85 36.65 780 108613 424515 110055391
Bradycardia 122.28 36.65 8 109385 155509 110324397
Foot deformity 121.01 36.65 191 109202 48289 110431617
Chest discomfort 120.49 36.65 15 109378 173833 110306073
Pregnancy 120.36 36.65 196 109197 50871 110429035
Tremor 119.11 36.65 27 109366 202205 110277701
Diarrhoea 117.10 36.65 656 108737 1138849 109341057
Influenza 116.20 36.65 15 109378 169086 110310820
Nausea 116.12 36.65 732 108661 1234958 109244948
Gastrointestinal haemorrhage 115.40 36.65 14 109379 165504 110314402
Cardiac failure congestive 115.17 36.65 9 109384 150991 110328915
Back injury 114.54 36.65 184 109209 47215 110432691
Hip arthroplasty 114.03 36.65 201 109192 55612 110424294
Feeling abnormal 112.90 36.65 21 109372 180690 110299216
Subcutaneous drug absorption impaired 111.47 36.65 78 109315 7581 110472325
Aspartate aminotransferase increased 110.35 36.65 14 109379 159922 110319984
Blood glucose increased 109.80 36.65 5 109388 132491 110347415
Muscle spasms 109.23 36.65 554 108839 277603 110202303
Delirium 108.65 36.65 337 109056 134688 110345218
Finger deformity 108.10 36.65 148 109245 32944 110446962
Drug intolerance 107.31 36.65 729 108664 405783 110074123
Therapy non-responder 107.17 36.65 371 109022 156936 110322970
Dysphagia 107.07 36.65 13 109380 153587 110326319
Hyperkalaemia 106.72 36.65 7 109386 135789 110344117
Hypokalaemia 106.17 36.65 25 109368 182423 110297483
C-reactive protein increased 106.03 36.65 462 108931 217457 110262449
Adverse reaction 105.31 36.65 138 109255 29456 110450450
Hepatic cirrhosis 104.18 36.65 216 109177 67410 110412496
Pleural effusion 102.13 36.65 25 109368 177684 110302222
Intentional product use issue 101.74 36.65 500 108893 247406 110232500
Septic shock 101.25 36.65 17 109376 157511 110322395
Ear infection 99.74 36.65 203 109190 62529 110417377
Hyperhidrosis 98.96 36.65 31 109362 187267 110292639
Inappropriate schedule of product administration 98.52 36.65 39 109354 203598 110276308
Drug hypersensitivity 97.39 36.65 775 108618 453315 110026591
Drug tolerance decreased 97.34 36.65 128 109265 27412 110452494
Heart rate increased 95.89 36.65 14 109379 143820 110336086
Malignant neoplasm progression 95.68 36.65 27 109366 174540 110305366
Dry skin 92.83 36.65 3 109390 107650 110372256
Off label use 92.74 36.65 994 108399 1499191 108980715
Vision blurred 92.22 36.65 10 109383 129012 110350894
Swollen joint count 91.89 36.65 73 109320 8601 110471305
Loss of consciousness 91.10 36.65 40 109353 196266 110283640
Multiple organ dysfunction syndrome 89.84 36.65 20 109373 151690 110328216
Thrombocytopenia 88.40 36.65 130 109263 348755 110131151
Oropharyngeal pain 88.28 36.65 14 109379 135262 110344644
Haematochezia 87.78 36.65 7 109386 115517 110364389
Cellulitis 87.01 36.65 11 109382 126005 110353901
Epistaxis 86.19 36.65 13 109380 130359 110349547
Product label confusion 85.78 36.65 109 109284 22568 110457338
Joint stiffness 84.58 36.65 198 109195 67045 110412861
General symptom 84.33 36.65 70 109323 8776 110471130
Breast cancer stage II 84.28 36.65 119 109274 27256 110452650
Herpes zoster 81.15 36.65 7 109386 108372 110371534
Hypoglycaemia 80.49 36.65 10 109383 116094 110363812
Knee arthroplasty 80.34 36.65 190 109203 64758 110415148
Red blood cell sedimentation rate increased 80.01 36.65 213 109180 78089 110401817
Haemorrhage 79.59 36.65 7 109386 106685 110373221
Joint dislocation 78.91 36.65 130 109263 34060 110445846
Frequent bowel movements 78.90 36.65 200 109193 71190 110408716
Colitis ulcerative 78.60 36.65 210 109183 77153 110402753
Rhabdomyolysis 77.36 36.65 13 109380 120388 110359518
Oxygen saturation decreased 76.03 36.65 30 109363 156952 110322954
Lactic acidosis 75.31 36.65 4 109389 92807 110387099
Chronic obstructive pulmonary disease 74.23 36.65 10 109383 109148 110370758
Taste disorder 74.16 36.65 185 109208 65202 110414704
Electrocardiogram QT prolonged 74.05 36.65 10 109383 108950 110370956
Wrong technique in product usage process 73.35 36.65 3 109390 87345 110392561
International normalised ratio increased 72.80 36.65 3 109390 86769 110393137
Pustular psoriasis 72.53 36.65 78 109315 13527 110466379
Exposure during pregnancy 72.49 36.65 343 109050 167081 110312825
Angioedema 72.04 36.65 7 109386 98493 110381413
Neutrophil count decreased 71.49 36.65 16 109377 120925 110358981
Deep vein thrombosis 70.66 36.65 25 109368 139862 110340044
Suicidal ideation 70.52 36.65 6 109387 93931 110385975
Anaphylactic reaction 69.86 36.65 14 109379 114286 110365620
Vertigo 69.69 36.65 4 109389 86866 110393040
Diabetes mellitus 67.83 36.65 9 109384 99372 110380534
Dyspnoea exertional 67.38 36.65 11 109382 104049 110375857
Paraesthesia 66.51 36.65 485 108908 276036 110203870
Abdominal pain upper 66.33 36.65 580 108813 348531 110131375
Rash vesicular 66.11 36.65 77 109316 14575 110465331
Haematuria 66.05 36.65 4 109389 83001 110396905
Cataract 65.85 36.65 3 109390 79482 110400424
Colitis 65.84 36.65 11 109382 102312 110377594
Disability 64.54 36.65 111 109282 30112 110449794
Stress 64.19 36.65 13 109380 105335 110374571
Drug ineffective for unapproved indication 64.11 36.65 12 109381 102826 110377080
Incorrect dose administered 62.71 36.65 13 109380 103628 110376278
Epilepsy 61.95 36.65 229 109164 99980 110379926
Hypertension 61.64 36.65 773 108620 509311 109970595
Flushing 61.62 36.65 14 109379 104722 110375184
Laboratory test abnormal 61.21 36.65 135 109258 43944 110435962
Underdose 60.05 36.65 168 109225 63386 110416520
Chronic kidney disease 59.74 36.65 4 109389 76287 110403619
Thrombosis 59.17 36.65 17 109376 108645 110371261
Sleep disorder due to a general medical condition 58.63 36.65 147 109246 51965 110427941
Injection site reaction 57.99 36.65 207 109186 88863 110391043
Rhinorrhoea 57.90 36.65 15 109378 102651 110377255
Hyperglycaemia 57.37 36.65 8 109385 85082 110394824
Pneumonia 56.75 36.65 574 108819 876140 109603766
Liver function test increased 56.12 36.65 204 109189 88344 110391562
Blood pressure decreased 55.72 36.65 22 109371 115069 110364837
Metabolic acidosis 55.44 36.65 15 109378 99729 110380177
Ascites 55.42 36.65 12 109381 92796 110387110
Hallucination 54.99 36.65 16 109377 101416 110378490
Coma 54.70 36.65 24 109369 117845 110362061
Mucosal inflammation 54.31 36.65 14 109379 96127 110383779
Cardiac disorder 54.29 36.65 6 109387 76274 110403632
Dysarthria 54.22 36.65 9 109384 84112 110395794
Nasal congestion 54.22 36.65 15 109378 98267 110381639
Coeliac disease 54.12 36.65 127 109266 43060 110436846
Dysphonia 53.97 36.65 6 109387 75923 110403983
Dysgeusia 53.84 36.65 4 109389 69981 110409925
Productive cough 53.48 36.65 23 109370 114282 110365624
Arrhythmia 53.46 36.65 4 109389 69571 110410335
Haematocrit decreased 53.17 36.65 3 109390 66114 110413792
Hot flush 53.10 36.65 3 109390 66033 110413873
Back disorder 52.99 36.65 83 109310 20839 110459067
Normal newborn 52.89 36.65 85 109308 21811 110458095
Toxicity to various agents 52.26 36.65 271 109122 480284 109999622
Rash erythematous 52.20 36.65 9 109384 81823 110398083
Product use issue 52.18 36.65 504 108889 311191 110168715
Cerebral haemorrhage 52.09 36.65 3 109390 64965 110414941
Blood alkaline phosphatase increased 51.98 36.65 5 109388 70930 110408976
Encephalopathy 51.52 36.65 9 109384 81046 110398860
Hypothyroidism 51.21 36.65 6 109387 72893 110407013
Lymphadenopathy 51.02 36.65 3 109390 63832 110416074
Skin exfoliation 51.00 36.65 12 109381 87639 110392267
Weight fluctuation 50.83 36.65 84 109309 22061 110457845
Pulmonary oedema 50.81 36.65 18 109375 100641 110379265
Eczema 50.66 36.65 6 109387 72287 110407619
Cholelithiasis 50.63 36.65 3 109390 63419 110416487
Plasma cell myeloma 50.17 36.65 3 109390 62933 110416973
Liver function test abnormal 50.16 36.65 5 109388 68945 110410961
Bone pain 49.33 36.65 4 109389 65129 110414777
Product quality issue 48.92 36.65 178 109215 77121 110402785
Speech disorder 48.89 36.65 3 109390 61566 110418340
Neoplasm progression 48.83 36.65 4 109389 64591 110415315
Drug-induced liver injury 48.37 36.65 241 109152 119826 110360080
Burning sensation 47.87 36.65 6 109387 69206 110410700
Hypomagnesaemia 47.76 36.65 3 109390 60367 110419539
Leukopenia 47.73 36.65 46 109347 148745 110331161
Transaminases increased 47.71 36.65 4 109389 63386 110416520
Fatigue 47.67 36.65 882 108511 1215076 109264830
Dysuria 47.63 36.65 3 109390 60228 110419678
Melaena 47.46 36.65 6 109387 68751 110411155
Depressed level of consciousness 47.34 36.65 26 109367 112252 110367654
Lethargy 46.78 36.65 17 109376 93559 110386347
Jaundice 46.69 36.65 3 109390 59233 110420673
Haematemesis 46.57 36.65 3 109390 59105 110420801
Aphasia 46.47 36.65 3 109390 58994 110420912
Disturbance in attention 46.42 36.65 4 109389 61991 110417915
Agranulocytosis 46.20 36.65 4 109389 61756 110418150
Asthma 46.04 36.65 413 108980 249878 110230028
Haematoma 45.98 36.65 3 109390 58473 110421433
Gamma-glutamyltransferase increased 45.79 36.65 4 109389 61305 110418601
Pneumonitis 45.48 36.65 10 109383 76521 110403385
Cardiogenic shock 44.91 36.65 3 109390 57335 110422571
Cardiac arrest 44.46 36.65 79 109314 196674 110283232
Eye injury 44.07 36.65 46 109347 7709 110472197
Osteoporosis 44.06 36.65 187 109206 86965 110392941
Unevaluable event 43.86 36.65 4 109389 59223 110420683
Sedation 43.72 36.65 8 109385 69675 110410231
Injection site swelling 43.62 36.65 5 109388 61785 110418121
Haemoptysis 43.06 36.65 9 109384 71345 110408561
Feeling hot 42.63 36.65 191 109202 90915 110388991
Drug reaction with eosinophilia and systemic symptoms 42.62 36.65 14 109379 82081 110397825
Blood creatine phosphokinase increased 42.52 36.65 10 109383 73067 110406839
Disorientation 42.47 36.65 9 109384 70662 110409244
Hypocalcaemia 42.11 36.65 7 109386 65359 110414547
Blood potassium decreased 41.90 36.65 3 109390 54111 110425795
Diverticulitis 41.34 36.65 3 109390 53519 110426387
Hepatic failure 40.81 36.65 9 109384 68730 110411176
Pulmonary hypertension 40.18 36.65 4 109389 55216 110424690
Cytokine release syndrome 40.17 36.65 10 109383 70296 110409610
Eosinophilia 40.13 36.65 5 109388 57931 110421975
Flatulence 40.06 36.65 3 109390 52146 110427760
Blood urea increased 39.94 36.65 4 109389 54953 110424953
Cerebral infarction 39.77 36.65 3 109390 51835 110428071
Pericardial effusion 39.48 36.65 5 109388 57212 110422694
Fungal infection 38.81 36.65 3 109390 50803 110429103
Viral infection 38.27 36.65 4 109389 53135 110426771
Hypoxia 38.20 36.65 43 109350 129472 110350434
Upper gastrointestinal haemorrhage 38.15 36.65 3 109390 50093 110429813
Agitation 37.38 36.65 34 109359 113017 110366889
Cytomegalovirus infection 36.98 36.65 5 109388 54439 110425467
Tubulointerstitial nephritis 36.84 36.65 5 109388 54279 110425627

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C05AD03 CARDIOVASCULAR SYSTEM
VASOPROTECTIVES
AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE
Local anesthetics
ATC D04AB04 DERMATOLOGICALS
ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC.
Anesthetics for topical use
ATC N01BA05 NERVOUS SYSTEM
ANESTHETICS
ANESTHETICS, LOCAL
Esters of aminobenzoic acid
ATC R02AD01 RESPIRATORY SYSTEM
THROAT PREPARATIONS
THROAT PREPARATIONS
Anesthetics, local
FDA CS M0000728 Allergens
MeSH PA D000777 Anesthetics
MeSH PA D000779 Anesthetics, Local
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D018689 Sensory System Agents
FDA PE N0000175629 Increased Histamine Release
FDA PE N0000184306 Cell-mediated Immunity
FDA EPC N0000185508 Standardized Chemical Allergen
CHEBI has role CHEBI:35480 analgesic
CHEBI has role CHEBI:38867 anaesthetic
CHEBI has role CHEBI:48425 topical anaesthetic
CHEBI has role CHEBI:50177 dermatologic drug
CHEBI has role CHEBI:50904 allergen
CHEBI has role CHEBI:59683 antipruritic drug
CHEBI has role CHEBI:65023 anti-asthmatic agent
CHEBI has role CHEBI:67079 anti-inflammatory agent
CHEBI has role CHEBI:74518 anti-obesity agent
CHEBI has role CHEBI:77715 nasal decongestant
CHEBI has role CHEBI:139492 sensitiser
CHEBI has role CHEBI:747329 lubricant

Related Drugs by ATC class:

C05AD Local anesthetics 6 drugs
cinchocainelidocaineoxetacainepramocaineprocainetetracaine
D04AB Anesthetics for topical use 6 drugs
cinchocainelidocaineoxybuprocainepramocainequinisocainetetracaine
N01BA Esters of aminobenzoic acid 4 drugs
chloroprocainemetabutethamineprocainetetracaine
R02AD Anesthetics, local 4 drugs
ambroxolcocainedycloninelidocaine

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Tinea pedis indication 6020002 DOID:12403
Cough indication 49727002
Tinea corporis indication 84849002
Sore throat symptom indication 267102003
Skin irritation indication 367466007
Local anesthesia indication 386761002
Itching of skin indication 418363000
Suppression of the Gag Reflex indication
Tinea Infections indication
Minor Skin Wound Pain indication
Mouth Irritation indication
Prevent Minor Bacterial Skin Infection indication
Hypocalcemia off-label use 5291005
Otalgia off-label use 16001004
Impacted cerumen off-label use 18070006
Osteoporosis off-label use 64859006 DOID:11476
Postmenopausal osteoporosis off-label use 102447009
Indigestion off-label use 162031009
Renal Osteodystrophy with Hyperphosphatemia off-label use
Gastritis contraindication 4556007 DOID:4029
Suicidal thoughts contraindication 6471006
Alcoholism contraindication 7200002
Hyperammonemia contraindication 9360008
Infectious gastroenteritis contraindication 12463005
Hepatic encephalopathy contraindication 13920009 DOID:13413
Constipation contraindication 14760008 DOID:2089
Hypocupremia contraindication 19577007
Herpes zoster auricularis contraindication 21954000 DOID:9210
Sarcoidosis contraindication 31541009 DOID:11335
Dehydration contraindication 34095006
Depressive disorder contraindication 35489007
Methemoglobinemia contraindication 38959009 DOID:10783
Gastrointestinal ulcer contraindication 40845000
Body fluid retention contraindication 43498006
Conduction disorder of the heart contraindication 44808001
Encephalitis contraindication 45170000 DOID:9588
Disorder of cardiovascular system contraindication 49601007 DOID:1287
Bleeding hemorrhoids contraindication 51551000
Vitamin K deficiency contraindication 52675005 DOID:11249
Nasal polyp contraindication 52756005
Hepatic failure contraindication 59927004
Perforation of tympanic membrane contraindication 60442001
Diarrhea contraindication 62315008
Blood coagulation disorder contraindication 64779008 DOID:1247
Poisoning by phenobarbital contraindication 64921004
Substance abuse contraindication 66214007
Hypercalcemia contraindication 66931009 DOID:12678
Hyperparathyroidism contraindication 66999008 DOID:13543
Incontinence of feces contraindication 72042002
Hepatic coma contraindication 72836002 DOID:12550
Diabetes mellitus contraindication 73211009 DOID:9351
Sleep apnea contraindication 73430006 DOID:0050847
Factor II deficiency contraindication 73975000
Appendicitis contraindication 74400008 DOID:8337
Gastrointestinal hemorrhage contraindication 74474003
Thrombotic thrombocytopenic purpura contraindication 78129009 DOID:10772
Decreased respiratory function contraindication 80954004
Herpes simplex contraindication 88594005 DOID:8566
Kidney disease contraindication 90708001 DOID:557
Thyrotoxicosis contraindication 90739004 DOID:7997
Hemophilia contraindication 90935002
Diaper rash contraindication 91487003
Disorder of skin contraindication 95320005 DOID:37
Disorder of mucous membrane contraindication 95351003
Kidney stone contraindication 95570007
Anemia due to enzyme deficiency contraindication 111577008
Deficiency of glucose-6-phosphate dehydrogenase contraindication 124134002 DOID:2862
Deficiency of cytochrome-b>5< reductase contraindication 124184009
Open wound contraindication 125643001
Gastrointestinal obstruction contraindication 126765001
Seizure disorder contraindication 128613002
Tuberculosis of ear contraindication 186269001
Osteolysis contraindication 203522001
Gastroesophageal reflux disease contraindication 235595009 DOID:8534
Disease of liver contraindication 235856003 DOID:409
Disorder of electrolytes contraindication 237840007
Dyspnea contraindication 267036007
Anemia contraindication 271737000 DOID:2355
Eruption of skin contraindication 271807003 DOID:0050486
Pregnancy, function contraindication 289908002
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Neutropenic disorder contraindication 303011007 DOID:1227
Viral ear infection contraindication 312137007
Fungal ear infection contraindication 312148000
Infective otitis media contraindication 312218008
Cardiovascular event risk contraindication 395112001
Breastfeeding (mother) contraindication 413712001
Denuded skin contraindication 418242004
Porphyria contraindication 418470004
Fever greater than 100.4 Fahrenheit contraindication 426000000




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 2.5 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Sodium channel protein type 1 subunit alpha Ion channel BLOCKER SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE
Sodium channel protein type 2 subunit alpha Ion channel BLOCKER SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE
Sodium channel protein type 3 subunit alpha Ion channel BLOCKER SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE
Sodium channel protein type 4 subunit alpha Ion channel BLOCKER SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE
Sodium channel protein type 8 subunit alpha Ion channel BLOCKER SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE
Sodium channel protein type 9 subunit alpha Ion channel BLOCKER SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE
Sodium channel protein type 11 subunit alpha Ion channel BLOCKER SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE
Sodium channel protein type 10 subunit alpha Ion channel BLOCKER SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE
Sodium channel protein type 7 subunit alpha Ion channel BLOCKER SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE
Sodium channel protein type 5 subunit alpha Ion channel BLOCKER ED50 3.50 SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE

External reference:

IDSource
4018117 VUID
N0000146455 NUI
D00552 KEGG_DRUG
1049105 RXNORM
C0005059 UMLSCUI
CHEBI:116735 CHEBI
CHEMBL278172 ChEMBL_ID
DB01086 DRUGBANK_ID
D001566 MESH_DESCRIPTOR_UI
2337 PUBCHEM_CID
3953 INN_ID
U3RSY48JW5 UNII
199 MMSL
359 MMSL
4256 MMSL
23239-88-5 SECONDARY_CAS_RN
4018117 VANDF
001366 NDDF
387357002 SNOMEDCT_US
65020006 SNOMEDCT_US
U3RSY48JW5 INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Benzocaine 20% HUMAN OTC DRUG LABEL 1 0121-1077 SOLUTION 200 mg TOPICAL OTC Monograph Drug 14 sections
HurriCaineTopical Anesthetic HUMAN OTC DRUG LABEL 1 0283-0220 GEL 200 mg DENTAL OTC Monograph Drug 12 sections
HurriCaineTopical Anesthetic Gel HUMAN OTC DRUG LABEL 1 0283-0293 GEL 200 mg ORAL OTC Monograph Drug 12 sections
HurriCaineTopical Anesthetic Gel HUMAN OTC DRUG LABEL 1 0283-0293 GEL 200 mg ORAL OTC Monograph Drug 12 sections
HurriCaineTopical Anesthetic Gel HUMAN OTC DRUG LABEL 1 0283-0293 GEL 200 mg ORAL OTC Monograph Drug 12 sections
HurriCaineTopical Anesthetic Gel HUMAN OTC DRUG LABEL 1 0283-0293 GEL 200 mg ORAL OTC Monograph Drug 12 sections
HurriCaineTopical Anesthetic HUMAN OTC DRUG LABEL 1 0283-0520 GEL 200 mg ORAL OTC Monograph Drug 12 sections
HurriCaineTopical Anesthetic HUMAN OTC DRUG LABEL 1 0283-0520 GEL 200 mg ORAL OTC Monograph Drug 12 sections
HurriCaineTopical Anesthetic HUMAN OTC DRUG LABEL 1 0283-0520 GEL 200 mg ORAL OTC Monograph Drug 12 sections
HurriCaineTopical Anesthetic HUMAN OTC DRUG LABEL 1 0283-0522 GEL 200 mg DENTAL OTC Monograph Drug 12 sections
HurriCaineTopical Anesthetic Liquid HUMAN OTC DRUG LABEL 1 0283-0569 LIQUID 200 mg DENTAL OTC Monograph Drug 12 sections
HurriCaineTopical Anesthetic Liquid HUMAN OTC DRUG LABEL 1 0283-0569 LIQUID 200 mg DENTAL OTC Monograph Drug 12 sections
HurriCaine HUMAN OTC DRUG LABEL 1 0283-0610 SPRAY 200 mg PERIODONTAL OTC Monograph Drug 12 sections
HurriCaine HUMAN OTC DRUG LABEL 1 0283-0610 SPRAY 200 mg PERIODONTAL OTC Monograph Drug 12 sections
HurriCaineTopical Anesthetic HUMAN OTC DRUG LABEL 1 0283-0622 GEL 200 mg DENTAL OTC Monograph Drug 12 sections
HurriCaineTopical Anesthetic HUMAN OTC DRUG LABEL 1 0283-0679 SPRAY 200 mg ORAL OTC Monograph Drug 11 sections
HurriCaineTopical Anesthetic HUMAN OTC DRUG LABEL 1 0283-0871 GEL 200 mg ORAL OTC Monograph Drug 12 sections
HurriCaineTopical Anesthetic HUMAN OTC DRUG LABEL 1 0283-0871 GEL 200 mg ORAL OTC Monograph Drug 12 sections
HurriCaineTopical Anesthetic HUMAN OTC DRUG LABEL 1 0283-0871 GEL 200 mg ORAL OTC Monograph Drug 12 sections
HurriCaineTopical Anesthetic Gel HUMAN OTC DRUG LABEL 1 0283-0886 GEL 200 mg DENTAL OTC Monograph Drug 12 sections
HurriCaineTopical Anesthetic Gel HUMAN OTC DRUG LABEL 1 0283-0886 GEL 200 mg DENTAL OTC Monograph Drug 12 sections
HurriCaineTopical Anesthetic Gel HUMAN OTC DRUG LABEL 1 0283-0886 GEL 200 mg DENTAL OTC Monograph Drug 12 sections
HurriCaineTopical Anesthetic HUMAN OTC DRUG LABEL 1 0283-0914 SPRAY 200 mg ORAL OTC Monograph Drug 11 sections
HurriCaineTopical Anesthetic HUMAN OTC DRUG LABEL 1 0283-0920 GEL 200 mg ORAL OTC Monograph Drug 12 sections
HurriCaineTopical Anesthetic HUMAN OTC DRUG LABEL 1 0283-0920 GEL 200 mg ORAL OTC Monograph Drug 12 sections
HurriCaineTopical Anesthetic HUMAN OTC DRUG LABEL 1 0283-0920 GEL 200 mg ORAL OTC Monograph Drug 12 sections
HurriCaineTopical Anesthetic HUMAN OTC DRUG LABEL 1 0283-0998 GEL 200 mg DENTAL OTC Monograph Drug 13 sections
HurriCaineTopical Anesthetic HUMAN OTC DRUG LABEL 1 0283-0998 GEL 200 mg DENTAL OTC Monograph Drug 13 sections
HurriCaineTopical Anesthetic HUMAN OTC DRUG LABEL 1 0283-1016 GEL 200 mg ORAL OTC Monograph Drug 12 sections
HurriCaineTopical Anesthetic HUMAN OTC DRUG LABEL 1 0283-1016 GEL 200 mg ORAL OTC Monograph Drug 12 sections