Stem definition | Drug id | CAS RN |
---|---|---|
local anaesthetics | 323 | 94-09-7 |
None
None
Date | Agency | Company | Orphan |
---|---|---|---|
None | FDA |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Methaemoglobinaemia | 304.21 | 19.81 | 60 | 2971 | 2102 | 46680929 |
Completed suicide | 92.46 | 19.81 | 76 | 2955 | 145844 | 46537187 |
Toxicity to various agents | 84.44 | 19.81 | 85 | 2946 | 211681 | 46471350 |
Gastrointestinal toxicity | 78.66 | 19.81 | 23 | 3008 | 4308 | 46678723 |
Pulmonary toxicity | 72.53 | 19.81 | 22 | 3009 | 4671 | 46678360 |
Drug hypersensitivity | 71.11 | 19.81 | 83 | 2948 | 243742 | 46439289 |
Drug abuse | 69.43 | 19.81 | 46 | 2985 | 63362 | 46619669 |
Neoplasm malignant | 46.53 | 19.81 | 25 | 3006 | 23474 | 46659557 |
Respiratory arrest | 45.59 | 19.81 | 28 | 3003 | 33788 | 46649243 |
Cyanosis | 43.28 | 19.81 | 21 | 3010 | 15950 | 46667081 |
C-reactive protein abnormal | 43.15 | 19.81 | 23 | 3008 | 21247 | 46661784 |
Joint injury | 42.46 | 19.81 | 22 | 3009 | 19187 | 46663844 |
Hepatotoxicity | 42.35 | 19.81 | 24 | 3007 | 24985 | 46658046 |
Therapy non-responder | 33.66 | 19.81 | 25 | 3006 | 41127 | 46641904 |
Cardiac arrest | 31.73 | 19.81 | 34 | 2997 | 90365 | 46592666 |
Cardio-respiratory arrest | 29.31 | 19.81 | 27 | 3004 | 59842 | 46623189 |
Intentional product misuse | 28.57 | 19.81 | 24 | 3007 | 47104 | 46635927 |
Joint stiffness | 28.01 | 19.81 | 19 | 3012 | 27089 | 46655942 |
Musculoskeletal pain | 23.93 | 19.81 | 26 | 3005 | 70102 | 46612929 |
Postmortem blood drug level increased | 20.80 | 19.81 | 5 | 3026 | 440 | 46682591 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Drug abuse | 213.29 | 24.09 | 115 | 2508 | 81957 | 29867898 |
Methaemoglobinaemia | 184.45 | 24.09 | 43 | 2580 | 2467 | 29947388 |
Intentional product misuse | 150.40 | 24.09 | 69 | 2554 | 34598 | 29915257 |
Toxicity to various agents | 116.75 | 24.09 | 107 | 2516 | 177076 | 29772779 |
Serotonin syndrome | 69.32 | 24.09 | 33 | 2590 | 17858 | 29931997 |
Respiratory arrest | 59.27 | 24.09 | 35 | 2588 | 29223 | 29920632 |
Completed suicide | 57.34 | 24.09 | 56 | 2567 | 99436 | 29850419 |
Hangover | 41.46 | 24.09 | 11 | 2612 | 1067 | 29948788 |
Mydriasis | 35.50 | 24.09 | 15 | 2608 | 6128 | 29943727 |
Cardiac arrest | 35.31 | 24.09 | 42 | 2581 | 92808 | 29857047 |
Intentional overdose | 26.94 | 24.09 | 25 | 2598 | 41456 | 29908399 |
Overdose | 25.43 | 24.09 | 34 | 2589 | 84303 | 29865552 |
Cardio-respiratory arrest | 25.25 | 24.09 | 28 | 2595 | 57278 | 29892577 |
Blood methaemoglobin present | 25.06 | 24.09 | 4 | 2619 | 28 | 29949827 |
Rebound effect | 24.70 | 24.09 | 8 | 2615 | 1553 | 29948302 |
Source | Code | Description |
---|---|---|
ATC | C05AD03 | CARDIOVASCULAR SYSTEM VASOPROTECTIVES AGENTS FOR TREATMENT OF HEMORRHOIDS AND ANAL FISSURES FOR TOPICAL USE Local anesthetics |
ATC | D04AB04 | DERMATOLOGICALS ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC. ANTIPRURITICS, INCL. ANTIHISTAMINES, ANESTHETICS, ETC. Anesthetics for topical use |
ATC | N01BA05 | NERVOUS SYSTEM ANESTHETICS ANESTHETICS, LOCAL Esters of aminobenzoic acid |
ATC | R02AD01 | RESPIRATORY SYSTEM THROAT PREPARATIONS THROAT PREPARATIONS Anesthetics, local |
FDA CS | M0000728 | Allergens |
FDA PE | N0000175629 | Increased Histamine Release |
MeSH PA | D000777 | Anesthetics |
MeSH PA | D000779 | Anesthetics, Local |
MeSH PA | D002491 | Central Nervous System Agents |
MeSH PA | D002492 | Central Nervous System Depressants |
MeSH PA | D018373 | Peripheral Nervous System Agents |
MeSH PA | D018689 | Sensory System Agents |
FDA PE | N0000184306 | Cell-mediated Immunity |
FDA EPC | N0000185508 | Standardized Chemical Allergen |
CHEBI has role | CHEBI:48425 | topical anaesthetics |
CHEBI has role | CHEBI:50904 | allergene |
CHEBI has role | CHEBI:59683 | anti-itching drug |
CHEBI has role | CHEBI:139492 | sensitizer |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Tinea pedis | indication | 6020002 | DOID:12403 |
Cough | indication | 49727002 | |
Tinea corporis | indication | 84849002 | |
Sore throat symptom | indication | 267102003 | |
Skin irritation | indication | 367466007 | |
Local anesthesia | indication | 386761002 | |
Itching of skin | indication | 418363000 | |
Suppression of the Gag Reflex | indication | ||
Tinea Infections | indication | ||
Minor Skin Wound Pain | indication | ||
Mouth Irritation | indication | ||
Prevent Minor Bacterial Skin Infection | indication | ||
Hypocalcemia | off-label use | 5291005 | |
Otalgia | off-label use | 16001004 | |
Impacted cerumen | off-label use | 18070006 | |
Osteoporosis | off-label use | 64859006 | DOID:11476 |
Postmenopausal osteoporosis | off-label use | 102447009 | |
Indigestion | off-label use | 162031009 | |
Renal Osteodystrophy with Hyperphosphatemia | off-label use | ||
Gastritis | contraindication | 4556007 | DOID:4029 |
Suicidal thoughts | contraindication | 6471006 | |
Alcoholism | contraindication | 7200002 | |
Hyperammonemia | contraindication | 9360008 | |
Infectious gastroenteritis | contraindication | 12463005 | |
Hepatic encephalopathy | contraindication | 13920009 | DOID:13413 |
Constipation | contraindication | 14760008 | DOID:2089 |
Hypocupremia | contraindication | 19577007 | |
Herpes zoster auricularis | contraindication | 21954000 | DOID:9210 |
Sarcoidosis | contraindication | 31541009 | DOID:11335 |
Dehydration | contraindication | 34095006 | |
Depressive disorder | contraindication | 35489007 | |
Methemoglobinemia | contraindication | 38959009 | DOID:10783 |
Gastrointestinal ulcer | contraindication | 40845000 | |
Body fluid retention | contraindication | 43498006 | |
Conduction disorder of the heart | contraindication | 44808001 | |
Encephalitis | contraindication | 45170000 | DOID:9588 |
Disorder of cardiovascular system | contraindication | 49601007 | DOID:1287 |
Bleeding hemorrhoids | contraindication | 51551000 | |
Vitamin K deficiency | contraindication | 52675005 | DOID:11249 |
Nasal polyp | contraindication | 52756005 | |
Hepatic failure | contraindication | 59927004 | |
Perforation of tympanic membrane | contraindication | 60442001 | |
Diarrhea | contraindication | 62315008 | |
Blood coagulation disorder | contraindication | 64779008 | DOID:1247 |
Poisoning by phenobarbital | contraindication | 64921004 | |
Substance abuse | contraindication | 66214007 | |
Hypercalcemia | contraindication | 66931009 | DOID:12678 |
Hyperparathyroidism | contraindication | 66999008 | DOID:13543 |
Incontinence of feces | contraindication | 72042002 | |
Hepatic coma | contraindication | 72836002 | DOID:12550 |
Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
Sleep apnea | contraindication | 73430006 | DOID:0050847 |
Factor II deficiency | contraindication | 73975000 | |
Appendicitis | contraindication | 74400008 | DOID:8337 |
Gastrointestinal hemorrhage | contraindication | 74474003 | |
Thrombotic thrombocytopenic purpura | contraindication | 78129009 | DOID:10772 |
Decreased respiratory function | contraindication | 80954004 | |
Herpes simplex | contraindication | 88594005 | DOID:8566 |
Kidney disease | contraindication | 90708001 | DOID:557 |
Thyrotoxicosis | contraindication | 90739004 | DOID:7997 |
Hemophilia | contraindication | 90935002 | |
Diaper rash | contraindication | 91487003 | |
Disorder of skin | contraindication | 95320005 | DOID:37 |
Disorder of mucous membrane | contraindication | 95351003 | |
Kidney stone | contraindication | 95570007 | |
Anemia due to enzyme deficiency | contraindication | 111577008 | |
Deficiency of glucose-6-phosphate dehydrogenase | contraindication | 124134002 | DOID:2862 |
Deficiency of cytochrome-b>5< reductase | contraindication | 124184009 | |
Open wound | contraindication | 125643001 | |
Gastrointestinal obstruction | contraindication | 126765001 | |
Seizure disorder | contraindication | 128613002 | |
Tuberculosis of ear | contraindication | 186269001 | |
Osteolysis | contraindication | 203522001 | |
Gastroesophageal reflux disease | contraindication | 235595009 | DOID:8534 |
Disease of liver | contraindication | 235856003 | DOID:409 |
Disorder of electrolytes | contraindication | 237840007 | |
Dyspnea | contraindication | 267036007 | |
Anemia | contraindication | 271737000 | DOID:2355 |
Eruption of skin | contraindication | 271807003 | DOID:0050486 |
Pregnancy, function | contraindication | 289908002 | |
Thrombocytopenic disorder | contraindication | 302215000 | DOID:1588 |
Neutropenic disorder | contraindication | 303011007 | DOID:1227 |
Viral ear infection | contraindication | 312137007 | |
Fungal ear infection | contraindication | 312148000 | |
Infective otitis media | contraindication | 312218008 | |
Cardiovascular event risk | contraindication | 395112001 | |
Breastfeeding (mother) | contraindication | 413712001 | |
Denuded skin | contraindication | 418242004 | |
Porphyria | contraindication | 418470004 | |
Fever greater than 100.4 Fahrenheit | contraindication | 426000000 |
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 2.5 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Sodium channel protein type 5 subunit alpha | Ion channel | BLOCKER | ED50 | 3.49 | SCIENTIFIC LITERATURE | SCIENTIFIC LITERATURE | |||
Sodium channel protein type 1 subunit alpha | Ion channel | BLOCKER | SCIENTIFIC LITERATURE | SCIENTIFIC LITERATURE | |||||
Sodium channel protein type 2 subunit alpha | Ion channel | BLOCKER | SCIENTIFIC LITERATURE | SCIENTIFIC LITERATURE | |||||
Sodium channel protein type 3 subunit alpha | Ion channel | BLOCKER | SCIENTIFIC LITERATURE | SCIENTIFIC LITERATURE | |||||
Sodium channel protein type 4 subunit alpha | Ion channel | BLOCKER | SCIENTIFIC LITERATURE | SCIENTIFIC LITERATURE | |||||
Sodium channel protein type 7 subunit alpha | Ion channel | BLOCKER | SCIENTIFIC LITERATURE | SCIENTIFIC LITERATURE | |||||
Sodium channel protein type 8 subunit alpha | Ion channel | BLOCKER | SCIENTIFIC LITERATURE | SCIENTIFIC LITERATURE | |||||
Sodium channel protein type 9 subunit alpha | Ion channel | BLOCKER | SCIENTIFIC LITERATURE | SCIENTIFIC LITERATURE | |||||
Sodium channel protein type 10 subunit alpha | Ion channel | BLOCKER | SCIENTIFIC LITERATURE | SCIENTIFIC LITERATURE | |||||
Sodium channel protein type 11 subunit alpha | Ion channel | BLOCKER | SCIENTIFIC LITERATURE | SCIENTIFIC LITERATURE |
ID | Source |
---|---|
U3RSY48JW5 | UNII |
4018117 | VUID |
N0000146455 | NUI |
D00552 | KEGG_DRUG |
23239-88-5 | SECONDARY_CAS_RN |
4018117 | VANDF |
C0813697 | UMLSCUI |
CHEBI:116735 | CHEBI |
CHEMBL278172 | ChEMBL_ID |
2337 | PUBCHEM_CID |
DB01086 | DRUGBANK_ID |
D001566 | MESH_DESCRIPTOR_UI |
3953 | INN_ID |
1049105 | RXNORM |
199 | MMSL |
359 | MMSL |
4256 | MMSL |
001366 | NDDF |
387357002 | SNOMEDCT_US |
65020006 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
good sense vagicaineanti itch | HUMAN OTC DRUG LABEL | 2 | 0113-0142 | CREAM | 20 g | TOPICAL | OTC monograph not final | 13 sections |
HurriCaine Topical Anesthetic | HUMAN OTC DRUG LABEL | 1 | 0283-0220 | GEL | 200 mg | ORAL | OTC monograph not final | 12 sections |
HurriCaineTopical Anesthetic Gel | HUMAN OTC DRUG LABEL | 1 | 0283-0293 | GEL | 200 mg | ORAL | OTC monograph not final | 12 sections |
HurriCaineTopical Anesthetic Gel | HUMAN OTC DRUG LABEL | 1 | 0283-0293 | GEL | 200 mg | ORAL | OTC monograph not final | 12 sections |
HurriCaineTopical Anesthetic Gel | HUMAN OTC DRUG LABEL | 1 | 0283-0293 | GEL | 200 mg | ORAL | OTC monograph not final | 12 sections |
HurriCaine Topical Anesthetic | HUMAN OTC DRUG LABEL | 1 | 0283-0520 | GEL | 200 mg | ORAL | OTC monograph not final | 12 sections |
HurriCaineTopical Anesthetic Liquid | HUMAN OTC DRUG LABEL | 1 | 0283-0569 | LIQUID | 200 mg | DENTAL | OTC monograph not final | 12 sections |
HurriCaine | HUMAN OTC DRUG LABEL | 1 | 0283-0610 | SPRAY | 200 mg | DENTAL | OTC monograph not final | 12 sections |
HurriCaine Topical Anesthetic | HUMAN OTC DRUG LABEL | 1 | 0283-0679 | SPRAY | 200 mg | ORAL | OTC monograph not final | 11 sections |
HurriCaine Topical Anesthetic | HUMAN OTC DRUG LABEL | 1 | 0283-0871 | GEL | 200 mg | ORAL | OTC monograph not final | 12 sections |
HurriCaine Topical Anesthetic | HUMAN OTC DRUG LABEL | 1 | 0283-0871 | GEL | 200 mg | ORAL | OTC monograph not final | 12 sections |
HurriCaine Topical Anesthetic | HUMAN OTC DRUG LABEL | 1 | 0283-0871 | GEL | 200 mg | ORAL | OTC monograph not final | 12 sections |
HurriCaineTopical Anesthetic Gel | HUMAN OTC DRUG LABEL | 1 | 0283-0886 | GEL | 200 mg | ORAL | OTC monograph not final | 12 sections |
HurriCaineTopical Anesthetic Gel | HUMAN OTC DRUG LABEL | 1 | 0283-0886 | GEL | 200 mg | ORAL | OTC monograph not final | 12 sections |
HurriCaine Topical Anesthetic | HUMAN OTC DRUG LABEL | 1 | 0283-0914 | SPRAY | 200 mg | ORAL | OTC monograph not final | 11 sections |
HurriCaine Topical Anesthetic | HUMAN OTC DRUG LABEL | 1 | 0283-0920 | GEL | 200 mg | ORAL | OTC monograph not final | 12 sections |
HurriCaineTopical Anesthetic | HUMAN OTC DRUG LABEL | 1 | 0283-0998 | GEL | 200 mg | DENTAL | OTC monograph not final | 13 sections |
HurriCaineTopical Anesthetic | HUMAN OTC DRUG LABEL | 1 | 0283-0998 | GEL | 200 mg | DENTAL | OTC monograph not final | 13 sections |
HurriCaineTopical Anesthetic | HUMAN OTC DRUG LABEL | 1 | 0283-1016 | GEL | 200 mg | ORAL | OTC monograph not final | 12 sections |
HurriCaineTopical Anesthetic | HUMAN OTC DRUG LABEL | 1 | 0283-1016 | GEL | 200 mg | ORAL | OTC monograph not final | 12 sections |
HurriCaineTopical Anesthetic Liquid | HUMAN OTC DRUG LABEL | 1 | 0283-1116 | LIQUID | 200 mg | DENTAL | OTC monograph not final | 12 sections |
HurriCaine Topical Anesthetic | HUMAN OTC DRUG LABEL | 1 | 0283-1820 | GEL | 200 mg | ORAL | OTC monograph not final | 12 sections |
HurriCaineTopical Anesthetic Liquid | HUMAN OTC DRUG LABEL | 1 | 0283-1886 | LIQUID | 200 mg | DENTAL | OTC monograph not final | 12 sections |
4x Medicated Toothache and Gum Cream | HUMAN OTC DRUG LABEL | 4 | 0363-0607 | CREAM | 20 g | ORAL | OTC monograph not final | 10 sections |
Anti-Itch Regular Strength | HUMAN OTC DRUG LABEL | 2 | 0363-0621 | CREAM | 5 g | TOPICAL | OTC monograph final | 11 sections |
Well at Walgreens Anti-Itch Maximum Strength | HUMAN OTC DRUG LABEL | 2 | 0363-0674 | CREAM | 20 g | TOPICAL | OTC monograph final | 11 sections |
Cherry Sore Throat Lozenge | HUMAN OTC DRUG LABEL | 2 | 0363-1079 | LOZENGE | 15 mg | ORAL | OTC monograph not final | 14 sections |
Mixed Berry Sore Throat and Cough Lozenge | HUMAN OTC DRUG LABEL | 2 | 0363-1080 | LOZENGE | 7.50 mg | ORAL | OTC monograph not final | 15 sections |
Bite and Sting ReliefWell at Walgreens | HUMAN OTC DRUG LABEL | 1 | 0363-3190 | SPRAY | 5 g | TOPICAL | OTC monograph not final | 10 sections |
Walgreens Cold Sore Treatment | HUMAN OTC DRUG LABEL | 1 | 0363-3191 | OINTMENT | 5 mg | TOPICAL | OTC monograph not final | 8 sections |