diazepam 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
diazepam derivatives 852 439-14-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • RO-5-2807
  • diazepam
  • valium
A benzodiazepine with anticonvulsant, anxiolytic, sedative, muscle relaxant, and amnesic properties and a long duration of action. Its actions are mediated by enhancement of GAMMA-AMINOBUTYRIC ACID activity.
  • Molecular weight: 284.74
  • Formula: C16H13ClN2O
  • CLOGP: 2.96
  • LIPINSKI: 0
  • HAC: 3
  • HDO: 0
  • TPSA: 32.67
  • ALOGS: -4.37
  • ROTB: 1
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
10 mg O
10 mg P
10 mg R

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 2.86 mg/mL Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine) 0.50 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 2.01 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 99 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 1 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 0.38 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.02 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 42 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Nov. 15, 1963 FDA ROCHE

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug abuse 2744.67 9.95 1852 147499 70666 63269005
Toxicity to various agents 2468.51 9.95 2967 146384 244283 63095388
Intentional overdose 1760.40 9.95 1431 147920 72721 63266950
Completed suicide 1602.76 9.95 1840 147511 143833 63195838
Suicide attempt 1319.06 9.95 1115 148236 59803 63279868
Coma 839.64 9.95 890 148461 63474 63276197
Overdose 757.88 9.95 1130 148221 113948 63225723
Somnolence 753.26 9.95 1437 147914 177248 63162423
Respiratory arrest 586.85 9.95 538 148813 32107 63307564
Intentional self-injury 584.07 9.95 484 148867 25203 63314468
Drug withdrawal syndrome 578.33 9.95 493 148858 26701 63312970
Sopor 548.97 9.95 439 148912 21725 63317946
Poisoning deliberate 545.55 9.95 336 149015 10882 63328789
Drug dependence 541.49 9.95 454 148897 24029 63315642
Poisoning 491.27 9.95 339 149012 13361 63326310
Suicidal ideation 426.42 9.95 624 148727 61797 63277874
Pemphigus 410.08 9.95 4 149347 183722 63155949
Depressed level of consciousness 394.59 9.95 600 148751 61478 63278193
Intentional product misuse 387.51 9.95 589 148762 60328 63279343
Synovitis 385.10 9.95 12 149339 186906 63152765
Contraindicated product administered 368.22 9.95 41 149310 217607 63122064
Infusion related reaction 364.96 9.95 68 149283 245453 63094218
Agitation 351.06 9.95 557 148794 59200 63280471
Drug interaction 348.97 9.95 1258 148093 227873 63111798
Rheumatoid arthritis 343.38 9.95 87 149264 253732 63085939
Systemic lupus erythematosus 341.95 9.95 44 149307 208874 63130797
Cardio-respiratory arrest 340.06 9.95 550 148801 59409 63280262
Schizophrenia 335.18 9.95 237 149114 9715 63329956
Cardiac arrest 333.71 9.95 698 148653 91847 63247824
Serotonin syndrome 324.04 9.95 368 148983 28314 63311357
Glossodynia 314.73 9.95 29 149322 178847 63160824
Joint swelling 311.67 9.95 193 149158 327473 63012198
Drug intolerance 298.85 9.95 178 149173 308483 63031188
Psychotic disorder 297.46 9.95 334 149017 25378 63314293
Miosis 297.21 9.95 196 149155 7157 63332514
Respiratory depression 296.36 9.95 251 149100 13464 63326207
Arthropathy 296.14 9.95 92 149259 234700 63104971
Neuroleptic malignant syndrome 292.55 9.95 236 149115 11820 63327851
Treatment failure 281.43 9.95 62 149289 198981 63140690
Aggression 276.56 9.95 308 149043 23190 63316481
Pericarditis 262.12 9.95 11 149340 131568 63208103
Seizure 257.62 9.95 791 148560 131843 63207828
Therapeutic product effect decreased 255.89 9.95 69 149282 193118 63146553
Withdrawal syndrome 250.76 9.95 271 149080 19726 63319945
Alopecia 245.83 9.95 259 149092 337277 63002394
Hand deformity 235.05 9.95 45 149306 159412 63180259
Abdominal discomfort 235.03 9.95 245 149106 320640 63019031
Rash 225.29 9.95 630 148721 560241 62779430
Swelling 223.01 9.95 192 149159 275186 63064485
Wound 222.53 9.95 55 149296 163208 63176463
Bradypnoea 218.94 9.95 124 149227 3426 63336245
Discomfort 199.75 9.95 72 149279 167302 63172369
Disturbance in attention 198.59 9.95 337 149014 37852 63301819
Tremor 198.40 9.95 723 148628 131516 63208155
Peripheral swelling 196.99 9.95 201 149150 265741 63073930
Drug ineffective 195.06 9.95 1552 147799 1043213 62296458
Helicobacter infection 190.85 9.95 6 149345 92779 63246892
Substance abuse 189.11 9.95 126 149225 4681 63334990
Arthralgia 187.58 9.95 699 148652 569011 62770660
Hypomania 186.43 9.95 139 149212 6191 63333480
Mydriasis 180.48 9.95 179 149172 11777 63327894
Nasopharyngitis 175.20 9.95 204 149147 254053 63085618
Tachycardia 174.69 9.95 643 148708 117513 63222158
Duodenal ulcer perforation 171.33 9.95 8 149343 87201 63252470
Sedation 166.59 9.95 315 149036 38494 63301177
Hypersensitivity 162.62 9.95 274 149077 292411 63047260
Altered state of consciousness 159.00 9.95 243 149108 24987 63314684
Anxiety 158.27 9.95 963 148388 216578 63123093
Accidental overdose 154.71 9.95 230 149121 23079 63316592
Sinusitis 148.56 9.95 189 149162 226464 63113207
Folliculitis 146.61 9.95 4 149347 70313 63269358
Panic attack 146.28 9.95 219 149132 22112 63317559
Nightmare 145.88 9.95 202 149149 18992 63320679
Status epilepticus 141.62 9.95 177 149174 15056 63324615
Bradyphrenia 141.14 9.95 123 149228 6857 63332814
Muscle rigidity 139.20 9.95 153 149198 11347 63328324
Jaundice cholestatic 136.04 9.95 123 149228 7201 63332470
Dissociation 135.75 9.95 85 149266 2834 63336837
Depression 134.85 9.95 857 148494 195635 63144036
Infection 134.34 9.95 207 149144 228966 63110705
Diarrhoea 132.34 9.95 1064 148287 714302 62625369
Pain 130.93 9.95 1115 148236 739513 62600158
Urinary retention 130.11 9.95 246 149105 30055 63309616
Myoglobin urine present 127.63 9.95 53 149298 719 63338952
Off label use 127.57 9.95 997 148354 673465 62666206
Stomatitis 127.18 9.95 85 149266 138640 63201031
Muscle injury 125.17 9.95 7 149344 65338 63274333
Asphyxia 123.13 9.95 108 149243 6073 63333598
Product use issue 122.83 9.95 206 149145 220314 63119357
Restlessness 118.96 9.95 233 149118 29220 63310451
General physical health deterioration 116.98 9.95 183 149168 201219 63138452
Fatigue 115.44 9.95 1438 147913 886590 62453081
Drug withdrawal convulsions 113.57 9.95 59 149292 1366 63338305
Dyskinesia 110.17 9.95 237 149114 31765 63307906
Disorientation 107 9.95 266 149085 39186 63300485
Febrile neutropenia 106.67 9.95 74 149277 118375 63221296
Derealisation 104.92 9.95 53 149298 1155 63338516
Loss of consciousness 104.33 9.95 551 148800 117570 63222101
Impaired healing 103.55 9.95 56 149295 102486 63237185
Reversible airways obstruction 102.03 9.95 60 149291 1782 63337889
Dystonia 101.38 9.95 143 149208 13676 63325995
Exposure via ingestion 99.62 9.95 70 149281 2839 63336832
Anaemia 98.92 9.95 356 148995 293074 63046597
Hypothermia 98.84 9.95 140 149211 13441 63326230
Depersonalisation/derealisation disorder 98.56 9.95 53 149298 1319 63338352
Hyperhidrosis 97.97 9.95 507 148844 107329 63232342
Gastric pH decreased 97.96 9.95 44 149307 730 63338941
Vital capacity decreased 97.59 9.95 57 149294 1671 63338000
Mood swings 97.46 9.95 163 149188 18085 63321586
Irritability 97.05 9.95 224 149127 31470 63308201
Coma scale abnormal 96.61 9.95 87 149264 5066 63334605
Salivary hypersecretion 96.28 9.95 104 149247 7562 63332109
Dysarthria 95.50 9.95 268 149083 42443 63297228
Gastrointestinal disorder 93.91 9.95 102 149249 131137 63208534
Feeling of despair 93.68 9.95 62 149289 2277 63337394
Cogwheel rigidity 93.21 9.95 58 149293 1912 63337759
Accidental death 93.05 9.95 58 149293 1918 63337753
Speech disorder 92.88 9.95 257 149094 40372 63299299
Hepatic enzyme increased 92.74 9.95 212 149139 202116 63137555
C-reactive protein abnormal 91.27 9.95 4 149347 46092 63293579
Extrapyramidal disorder 90.92 9.95 133 149218 13151 63326520
Abnormal behaviour 90.81 9.95 173 149178 21253 63318418
Mania 90.77 9.95 128 149223 12239 63327432
Lower respiratory tract infection 90.13 9.95 107 149244 132200 63207471
Hypotension 89.61 9.95 1008 148343 271596 63068075
Agoraphobia 89.24 9.95 34 149317 362 63339309
Therapeutic product effect incomplete 86.41 9.95 100 149251 124956 63214715
Sputum culture positive 85.72 9.95 57 149294 2110 63337561
Psoriatic arthropathy 85.32 9.95 55 149296 91465 63248206
Emotional disorder 84.48 9.95 129 149222 13250 63326421
Drooling 83.98 9.95 71 149280 3797 63335874
Psychomotor hyperactivity 83.70 9.95 114 149237 10549 63329122
Hypotonia 83.30 9.95 106 149245 9179 63330492
Arthritis 83.04 9.95 90 149261 115831 63223840
Respiratory acidosis 82.42 9.95 90 149261 6625 63333046
Hallucinations, mixed 77.93 9.95 75 149276 4754 63334917
Hallucination 77.34 9.95 294 149057 54523 63285148
Generalised tonic-clonic seizure 75.92 9.95 193 149158 28823 63310848
Bronchial secretion retention 75.27 9.95 58 149293 2715 63336956
Irritable bowel syndrome 74.83 9.95 51 149300 82361 63257310
Pruritus 72.98 9.95 524 148827 360929 62978742
Knee arthroplasty 72.38 9.95 19 149332 54187 63285484
Tearfulness 71.98 9.95 67 149284 4072 63335599
Disease progression 69.86 9.95 113 149238 122645 63217026
Intentional product use issue 69.75 9.95 121 149230 127771 63211900
H1N1 influenza 69.41 9.95 46 149305 1693 63337978
Hallucination, auditory 69.08 9.95 115 149236 12709 63326962
Blood creatine phosphokinase increased 69.07 9.95 192 149159 30238 63309433
Dependence 68.86 9.95 49 149302 2028 63337643
Toxic encephalopathy 68.56 9.95 81 149270 6498 63333173
Cough 68.40 9.95 406 148945 292337 63047334
Dyspnoea 67.64 9.95 1122 148229 660191 62679480
Thrombocytopenia 67.14 9.95 161 149190 150996 63188675
Hip arthroplasty 66.95 9.95 15 149336 47631 63292040
Amylase increased 64.27 9.95 77 149274 6268 63333403
Malignant neoplasm progression 64.26 9.95 59 149292 82062 63257609
Feeling of body temperature change 64.26 9.95 68 149283 4829 63334842
Akathisia 61.76 9.95 91 149260 9055 63330616
Anger 60.91 9.95 107 149244 12349 63327322
Pneumonia aspiration 60.55 9.95 199 149152 34341 63305330
Parkinsonism 59.46 9.95 96 149255 10343 63329328
Unresponsive to stimuli 59.44 9.95 195 149156 33621 63306050
Inflammation 58.77 9.95 64 149287 82209 63257462
Delusion 58.46 9.95 103 149248 11914 63327757
Loss of personal independence in daily activities 57.78 9.95 87 149264 97203 63242468
Ataxia 57.50 9.95 117 149234 15078 63324593
Multiple sclerosis relapse 57.22 9.95 246 149105 48232 63291439
Lethargy 56.99 9.95 272 149079 55735 63283936
Depressed mood 56.23 9.95 215 149136 39976 63299695
Troponin increased 56.19 9.95 92 149259 10029 63329642
Balance disorder 55.23 9.95 364 148987 84058 63255613
Drug abuser 54.11 9.95 49 149302 2874 63336797
Self-injurious ideation 54.05 9.95 47 149304 2612 63337059
COVID-19 53.84 9.95 116 149235 112987 63226684
Multiple sclerosis 53.57 9.95 152 149199 24220 63315451
Fibromyalgia 52.68 9.95 67 149284 80353 63259318
Vision blurred 52.27 9.95 383 148968 91541 63248130
Neutropenia 52.08 9.95 223 149128 174782 63164889
Visceral congestion 51.72 9.95 22 149329 318 63339353
Liver injury 51.62 9.95 40 149311 60480 63279191
Developmental delay 51.52 9.95 36 149315 1447 63338224
Interstitial lung disease 51.44 9.95 42 149309 61866 63277805
Drug withdrawal syndrome neonatal 51.04 9.95 41 149310 2040 63337631
Victim of sexual abuse 50.76 9.95 27 149324 657 63339014
Electrocardiogram QT prolonged 50.69 9.95 275 149076 59255 63280416
Ill-defined disorder 50.62 9.95 71 149280 81684 63257987
Mental disorder 50.62 9.95 155 149196 25764 63313907
Psychomotor skills impaired 50.46 9.95 43 149308 2325 63337346
Restless legs syndrome 50.29 9.95 125 149226 18406 63321265
Blister 50.26 9.95 148 149203 129666 63210005
Urticaria 50.13 9.95 210 149141 165592 63174079
Immobilisation prolonged 50.11 9.95 16 149335 95 63339576
Mucosal inflammation 49.79 9.95 24 149327 46904 63292767
Catatonia 49.79 9.95 57 149294 4420 63335251
Psychomotor retardation 49.48 9.95 53 149298 3817 63335854
Asthma-chronic obstructive pulmonary disease overlap syndrome 49.26 9.95 40 149311 2021 63337650
Aspiration 47.70 9.95 89 149262 10762 63328909
Pulmonary fibrosis 47.66 9.95 17 149334 39792 63299879
Psychogenic seizure 47.26 9.95 36 149315 1656 63338015
Victim of child abuse 47.19 9.95 10 149341 4 63339667
Paralysis 47.06 9.95 84 149267 9816 63329855
Cyanosis 46.77 9.95 115 149236 16820 63322851
Product dose omission issue 46.59 9.95 341 149010 233972 63105699
Platelet count decreased 45.96 9.95 131 149220 115991 63223680
Cholelithiasis 45.91 9.95 215 149136 43710 63295961
Snoring 45.89 9.95 53 149298 4149 63335522
Injection site pain 45.33 9.95 155 149196 129645 63210026
Adverse event 44.55 9.95 56 149295 67503 63272168
Rhabdomyolysis 44.38 9.95 213 149138 43738 63295933
Renal ischaemia 44.21 9.95 24 149327 609 63339062
Haemoglobin decreased 44.14 9.95 184 149167 145301 63194370
Urinary incontinence 43.75 9.95 170 149181 31844 63307827
Rhesus incompatibility 43.44 9.95 14 149337 86 63339585
Total lung capacity increased 43.30 9.95 39 149312 2271 63337400
Swollen tongue 42.93 9.95 179 149172 34621 63305050
PCO2 increased 42.86 9.95 30 149321 1209 63338462
Pleurothotonus 42.83 9.95 31 149320 1318 63338353
Sinus tachycardia 42.70 9.95 140 149211 24128 63315543
Incontinence 42.17 9.95 88 149263 11544 63328127
Muscle disorder 41.87 9.95 55 149296 4914 63334757
Device expulsion 41.66 9.95 15 149336 34907 63304764
Neoplasm progression 41.21 9.95 17 149334 36411 63303260
Drowning 40.98 9.95 21 149330 472 63339199
Diabetes insipidus 40.91 9.95 40 149311 2585 63337086
Fluid retention 40.91 9.95 48 149303 59638 63280033
Paranoia 40.77 9.95 87 149264 11592 63328079
Physical assault 40.73 9.95 26 149325 897 63338774
Musculoskeletal stiffness 40.49 9.95 261 149090 184357 63155314
C-reactive protein increased 40.37 9.95 103 149248 94604 63245067
Type 2 diabetes mellitus 40.00 9.95 55 149296 63813 63275858
Gastrointestinal haemorrhage 39.68 9.95 82 149269 81094 63258577
Pancreatic fibrosis 39.65 9.95 13 149338 85 63339586
Bone marrow failure 39.61 9.95 10 149341 29280 63310391
PO2 increased 39.38 9.95 25 149326 854 63338817
Stiff person syndrome 39.26 9.95 18 149333 314 63339357
Confusional state 39.18 9.95 777 148574 235603 63104068
Alcohol poisoning 39.17 9.95 34 149317 1885 63337786
Pyrexia 39.04 9.95 827 148524 469651 62870020
Hyperprolactinaemia 38.97 9.95 47 149304 3853 63335818
Myoclonus 38.89 9.95 103 149248 15765 63323906
Obstructive airways disorder 38.77 9.95 122 149229 20577 63319094
Crying 38.71 9.95 132 149219 23211 63316460
Housebound 38.47 9.95 16 149335 218 63339453
Electroencephalogram abnormal 37.92 9.95 45 149306 3627 63336044
Adverse drug reaction 37.73 9.95 82 149269 79632 63260039
Hepatic necrosis 37.56 9.95 56 149295 5631 63334040
Delirium 37.45 9.95 225 149126 50316 63289355
Therapeutic product ineffective 37.39 9.95 32 149319 1740 63337931
Blood pressure systolic increased 37.14 9.95 34 149317 47363 63292308
Maternal exposure during pregnancy 36.99 9.95 335 149016 219727 63119944
Generalised anxiety disorder 36.89 9.95 34 149317 2040 63337631
Insomnia 36.83 9.95 711 148640 214541 63125130
Nasal congestion 36.82 9.95 61 149290 65599 63274072
Drug screen positive 36.69 9.95 44 149307 3585 63336086
Victim of chemical submission 36.68 9.95 20 149331 512 63339159
Right ventricular hypertrophy 36.59 9.95 22 149329 681 63338990
Aphasia 36.31 9.95 164 149187 32836 63306835
Menstrual disorder 36.07 9.95 53 149298 5260 63334411
Blood pH decreased 35.87 9.95 37 149314 2550 63337121
Mutism 35.55 9.95 30 149321 1600 63338071
Hypoxic-ischaemic encephalopathy 35.43 9.95 47 149304 4240 63335431
Drug diversion 35.26 9.95 24 149327 924 63338747
Cytomegalovirus infection 35.25 9.95 4 149347 20948 63318723
Parosmia 35.25 9.95 57 149294 6149 63333522
Antipsychotic drug level decreased 35.16 9.95 17 149334 336 63339335
Herpes zoster 34.90 9.95 90 149261 82372 63257299
Pleural effusion 34.83 9.95 108 149243 93102 63246569
Feeling jittery 33.87 9.95 88 149263 13315 63326356
Hypotonia neonatal 33.68 9.95 26 149325 1220 63338451
Social avoidant behaviour 33.16 9.95 38 149313 2950 63336721
Blood pressure fluctuation 33.11 9.95 36 149315 46281 63293390
Drug detoxification 33.10 9.95 16 149335 316 63339355
Injection site reaction 32.23 9.95 55 149296 58469 63281202
Oropharyngeal pain 32.19 9.95 114 149237 94373 63245298
Hepatotoxicity 32.13 9.95 172 149179 36869 63302802
Cortisol increased 32.02 9.95 17 149334 412 63339259
Flashback 32.01 9.95 13 149338 166 63339505
Cryopyrin associated periodic syndrome 31.87 9.95 16 149335 344 63339327
Panic reaction 31.82 9.95 44 149307 4130 63335541
Pyramidal tract syndrome 31.74 9.95 16 149335 347 63339324
Hypoventilation 31.67 9.95 47 149304 4707 63334964
Autonomic nervous system imbalance 31.55 9.95 36 149315 2782 63336889
Conversion disorder 31.54 9.95 29 149322 1735 63337936
Dyspnoea exertional 31.12 9.95 59 149292 60243 63279428
Pancytopenia 31.03 9.95 120 149231 96813 63242858
Pain in extremity 30.99 9.95 571 148780 330915 63008756
Sensory loss 30.94 9.95 72 149279 10166 63329505
Bone erosion 30.79 9.95 3 149348 17714 63321957
Abnormal dreams 30.74 9.95 73 149278 10443 63329228
Hypersomnia 30.73 9.95 103 149248 17952 63321719
Red blood cell sedimentation rate increased 30.54 9.95 35 149316 43947 63295724
Antipsychotic drug level increased 30.47 9.95 39 149312 3396 63336275
Drug level increased 30.47 9.95 120 149231 22616 63317055
Blood cholesterol increased 30.36 9.95 116 149235 93916 63245755
Atrial fibrillation 30.34 9.95 156 149195 116480 63223191
Autonomic dysreflexia 29.94 9.95 15 149336 321 63339350
Stupor 29.54 9.95 43 149308 4232 63335439
Posturing 29.52 9.95 17 149334 485 63339186
Somatic delusion 29.46 9.95 18 149333 574 63339097
Chemical submission 29.36 9.95 14 149337 268 63339403
Alcohol use 29.31 9.95 30 149321 2049 63337622
Hallucination, visual 29.30 9.95 106 149245 19192 63320479
Tardive dyskinesia 29.29 9.95 63 149288 8439 63331232
Emotional poverty 29.00 9.95 15 149336 344 63339327
Death 28.91 9.95 1115 148236 373266 62966405
Hypokinesia 28.78 9.95 85 149266 13851 63325820
Blood creatinine increased 28.60 9.95 108 149243 87736 63251935
Therapeutic response decreased 28.53 9.95 64 149287 61461 63278210
Abdominal pain 28.53 9.95 502 148849 292954 63046717
Tissue infiltration 28.46 9.95 18 149333 611 63339060
Suicidal behaviour 28.34 9.95 33 149318 2606 63337065
Urine osmolarity increased 28.23 9.95 11 149340 125 63339546
Respiratory rate decreased 28.06 9.95 38 149313 3497 63336174
Thinking abnormal 28.05 9.95 71 149280 10572 63329099
Injection site erythema 27.90 9.95 101 149250 83073 63256598
Sudden death 27.85 9.95 70 149281 10379 63329292
Somnambulism 27.60 9.95 48 149303 5495 63334176
Oedema 27.45 9.95 127 149224 97495 63242176
Calcium deficiency 27.43 9.95 22 149329 1092 63338579
Myocardial fibrosis 27.43 9.95 19 149332 753 63338918
Right ventricular dilatation 27.32 9.95 24 149327 1352 63338319
Urine sodium increased 27.26 9.95 10 149341 95 63339576
Erythema 27.20 9.95 273 149078 175478 63164193
Bezoar 27.11 9.95 25 149326 1501 63338170
Treatment noncompliance 26.91 9.95 165 149186 37160 63302511
Hypertonia 26.90 9.95 43 149308 4594 63335077
Eosinophil count increased 26.84 9.95 71 149280 10857 63328814
Asthma 26.62 9.95 183 149168 127378 63212293
Feeling drunk 26.24 9.95 40 149311 4102 63335569
Injection site pruritus 26.15 9.95 41 149310 45075 63294596
Anticonvulsant drug level above therapeutic 26.02 9.95 16 149335 516 63339155
Haemodynamic instability 26.01 9.95 63 149288 9127 63330544
Basal ganglion degeneration 25.89 9.95 15 149336 433 63339238
Blood bilirubin increased 25.42 9.95 162 149189 36978 63302693
Haematochezia 25.40 9.95 55 149296 53489 63286182
Marchiafava-Bignami disease 25.26 9.95 6 149345 8 63339663
Electrocardiogram QRS complex prolonged 25.22 9.95 48 149303 5890 63333781
Impaired reasoning 25.06 9.95 9 149342 80 63339591
Ventricular dyskinesia 25.03 9.95 10 149341 122 63339549
Product use in unapproved indication 24.96 9.95 285 149066 178795 63160876
Rhesus antigen positive 24.89 9.95 10 149341 124 63339547
Apnoea 24.89 9.95 57 149294 7965 63331706
Upper-airway cough syndrome 24.88 9.95 71 149280 11347 63328324
Blood potassium increased 24.83 9.95 97 149254 18212 63321459
Memory impairment 24.64 9.95 363 148988 103895 63235776
Osteoarthritis 24.52 9.95 128 149223 95215 63244456
Basal cell carcinoma 24.51 9.95 18 149333 27973 63311698
Productive cough 24.50 9.95 72 149279 63136 63276535
Blood osmolarity decreased 24.30 9.95 19 149332 909 63338762
Wheezing 24.22 9.95 129 149222 95466 63244205
Negativism 24.20 9.95 14 149337 403 63339268
Ductus arteriosus premature closure 24.19 9.95 13 149338 323 63339348
Upper respiratory tract infection 24.11 9.95 105 149246 81942 63257729
Terminal dribbling 24.11 9.95 6 149345 11 63339660
Blood sodium decreased 24.10 9.95 117 149234 24135 63315536
Obsessive-compulsive disorder 24.03 9.95 38 149313 4022 63335649
Sinus bradycardia 23.88 9.95 82 149269 14469 63325202
Mobility decreased 23.73 9.95 177 149174 120982 63218689
Emotional distress 23.54 9.95 144 149207 32405 63307266
Patient uncooperative 23.53 9.95 11 149340 201 63339470
Panic disorder 23.53 9.95 30 149321 2603 63337068
Distractibility 23.38 9.95 14 149337 430 63339241
Bradykinesia 23.36 9.95 43 149308 5145 63334526
Psoriasis 23.35 9.95 115 149236 86842 63252829
Drug use disorder 23.32 9.95 42 149309 4942 63334729
Tooth hypoplasia 23.12 9.95 8 149343 63 63339608
Logorrhoea 23.06 9.95 29 149322 2481 63337190
Hypotensive crisis 22.76 9.95 7 149344 36 63339635
Amnesia 22.70 9.95 215 149136 55370 63284301
Euphoric mood 22.63 9.95 41 149310 4846 63334825
Hospitalisation 22.57 9.95 113 149238 84968 63254703
Apathy 22.49 9.95 58 149293 8736 63330935
Sensory disturbance 22.39 9.95 77 149274 13595 63326076
Skin ulcer 22.31 9.95 42 149309 43003 63296668
Cardiac failure congestive 22.17 9.95 127 149224 92306 63247365
Negative symptoms in schizophrenia 22.16 9.95 9 149342 115 63339556
Bursitis 22.10 9.95 33 149318 37008 63302663
Spleen congestion 22.09 9.95 9 149342 116 63339555
Hyperthermia 22.00 9.95 59 149292 9097 63330574
Drug hypersensitivity 21.84 9.95 560 148791 310127 63029544
Liver function test increased 21.83 9.95 27 149324 32784 63306887
Neonatal complications of substance abuse 21.82 9.95 5 149346 5 63339666
Oral discomfort 21.81 9.95 59 149292 9142 63330529
Pulmonary congestion 21.80 9.95 90 149261 17328 63322343
Live birth 21.78 9.95 17 149334 25613 63314058
Affective disorder 21.70 9.95 46 149305 6100 63333571
Intellectual disability 21.68 9.95 19 149332 1067 63338604
Peripheral venous disease 21.49 9.95 5 149346 15472 63324199
Cardiac murmur 21.31 9.95 79 149272 14473 63325198
Hepatic steatosis 21.26 9.95 128 149223 28641 63311030
Joint range of motion decreased 21.25 9.95 27 149324 32401 63307270
Neurosis 21.08 9.95 11 149340 257 63339414
Psychotic symptom 21.06 9.95 22 149329 1539 63338132
Illness anxiety disorder 20.98 9.95 9 149342 133 63339538
Incoherent 20.97 9.95 38 149313 4492 63335179
Fear 20.96 9.95 83 149268 15683 63323988
Mental impairment 20.87 9.95 77 149274 14074 63325597
Sputum culture 20.85 9.95 11 149340 263 63339408
Blood pressure diastolic decreased 20.67 9.95 14 149337 22692 63316979
Circulatory collapse 20.49 9.95 104 149247 21834 63317837
Movement disorder 20.45 9.95 103 149248 21558 63318113
Pulmonary arterial hypertension 20.45 9.95 14 149337 22563 63317108
Behaviour disorder 20.41 9.95 31 149320 3168 63336503
Hyperacusis 20.36 9.95 25 149326 2088 63337583
Myelodysplastic syndrome 20.32 9.95 7 149344 16747 63322924
Bronchitis 20.19 9.95 192 149159 124743 63214928
Electrocardiogram QRS complex shortened 20.17 9.95 13 149338 456 63339215
Colitis ulcerative 20.10 9.95 19 149332 26072 63313599
Cardiac failure 20.05 9.95 125 149226 89017 63250654
Enterochromaffin cell hyperplasia 20.03 9.95 7 149344 57 63339614
Paraesthesia 19.97 9.95 497 148854 156469 63183202
Alcoholism 19.97 9.95 23 149328 1795 63337876
White blood cell count decreased 19.92 9.95 220 149131 138884 63200787
Muscle spasms 19.75 9.95 494 148857 155656 63184015
Suspected counterfeit product 19.74 9.95 12 149339 379 63339292
Macular degeneration 19.68 9.95 17 149334 24359 63315312
Illogical thinking 19.61 9.95 7 149344 61 63339610
Alpha 1 microglobulin increased 19.61 9.95 7 149344 61 63339610
Carcinoid tumour of the stomach 19.58 9.95 9 149342 158 63339513
Primitive reflex test positive 19.48 9.95 5 149346 11 63339660
Inadequate analgesia 19.47 9.95 29 149322 2914 63336757
Galactorrhoea 19.42 9.95 35 149316 4120 63335551
Hypervolaemia 19.31 9.95 23 149328 28390 63311281
Injection site swelling 19.31 9.95 53 149298 47519 63292152
Alcohol interaction 19.28 9.95 26 149325 2383 63337288
Lupus-like syndrome 19.24 9.95 6 149345 15289 63324382
Hypergastrinaemia 19.17 9.95 8 149343 110 63339561
Bladder dilatation 19.16 9.95 16 149335 841 63338830
Rash pruritic 19.15 9.95 74 149277 59725 63279946
Clonus 19.11 9.95 37 149314 4599 63335072
Nodule 19.10 9.95 13 149338 21013 63318658
Nystagmus 19.08 9.95 44 149307 6176 63333495
Joint stiffness 19.05 9.95 44 149307 41825 63297846
Colitis 19.01 9.95 55 149296 48473 63291198
Distal intestinal obstruction syndrome 19.01 9.95 12 149339 406 63339265
Pneumocystis jirovecii pneumonia 18.96 9.95 8 149343 16906 63322765
Myocarditis septic 18.74 9.95 6 149345 36 63339635
Foetal exposure during pregnancy 18.63 9.95 134 149217 31828 63307843
Feeling abnormal 18.63 9.95 469 148882 147923 63191748
Major depression 18.60 9.95 51 149300 7967 63331704
Myelosuppression 18.57 9.95 17 149334 23686 63315985
Suspected suicide 18.56 9.95 45 149306 6523 63333148
Sudden cardiac death 18.52 9.95 24 149327 2116 63337555
Vertigo 18.52 9.95 219 149132 59668 63280003
Slow response to stimuli 18.52 9.95 17 149334 1015 63338656
Congenital central nervous system anomaly 18.52 9.95 11 149340 333 63339338
Hypoaesthesia oral 18.45 9.95 70 149281 12963 63326708
Benzodiazepine drug level increased 18.38 9.95 9 149342 183 63339488
Oropharyngeal oedema 18.37 9.95 11 149340 338 63339333
Psychiatric symptom 18.34 9.95 39 149312 5184 63334487
Base excess 18.33 9.95 7 149344 75 63339596
Osteoporosis 18.33 9.95 71 149280 57267 63282404
Cerebrospinal fluid leakage 18.30 9.95 18 149333 1172 63338499
Potentiating drug interaction 18.24 9.95 35 149316 4321 63335350
Sarcoidosis 18.24 9.95 47 149304 7075 63332596
Fungal infection 18.23 9.95 37 149314 36837 63302834
Tenosynovitis 18.10 9.95 5 149346 13790 63325881
Blood bicarbonate decreased 18.07 9.95 28 149323 2913 63336758
Cataract 18.02 9.95 71 149280 56982 63282689
Abdominal tenderness 18.01 9.95 51 149300 8115 63331556
Prescription drug used without a prescription 17.96 9.95 25 149326 2361 63337310
Gallbladder cholesterolosis 17.92 9.95 15 149336 791 63338880
Acute kidney injury 17.92 9.95 477 148874 262938 63076733
Borderline personality disorder 17.84 9.95 15 149336 796 63338875
Tinnitus 17.76 9.95 144 149207 35484 63304187
Gastrointestinal motility disorder 17.71 9.95 38 149313 5081 63334590
Encephalopathy 17.61 9.95 153 149198 38467 63301204
Cardiac death 17.49 9.95 13 149338 576 63339095
Hemiparesis 17.47 9.95 104 149247 23178 63316493
Frequent bowel movements 17.46 9.95 17 149334 23005 63316666
Performance fear 17.46 9.95 4 149347 4 63339667
Dysphagia 17.37 9.95 299 149052 88286 63251385
Therapy non-responder 17.30 9.95 106 149245 75795 63263876
Epilepsy 17.27 9.95 116 149235 26949 63312722
Defect conduction intraventricular 17.22 9.95 8 149343 144 63339527
Diastolic hypotension 17.19 9.95 7 149344 90 63339581
Blood immunoglobulin M decreased 17.19 9.95 16 149335 972 63338699
Thymus disorder 17.19 9.95 10 149341 291 63339380
Pallor 17.16 9.95 127 149224 30441 63309230
Multiple allergies 17.03 9.95 71 149280 13731 63325940
Faecaloma 16.94 9.95 49 149302 7892 63331779
Rhinorrhoea 16.88 9.95 88 149263 65489 63274182
Cor pulmonale acute 16.86 9.95 11 149340 394 63339277
Sepsis 16.82 9.95 256 149095 152867 63186804
Hyperkalaemia 16.77 9.95 68 149283 54135 63285536
Accidental poisoning 16.75 9.95 13 149338 615 63339056
Disinhibition 16.73 9.95 15 149336 868 63338803
Foaming at mouth 16.73 9.95 17 149334 1151 63338520
Inappropriate schedule of product administration 16.70 9.95 160 149191 103805 63235866
Neutrophil count decreased 16.69 9.95 72 149279 56334 63283337
Nasal polyps 16.66 9.95 41 149310 5998 63333673
Body temperature decreased 16.61 9.95 14 149337 20305 63319366
Neuropathy peripheral 16.58 9.95 179 149172 113488 63226183
Wrong rate 16.54 9.95 6 149345 55 63339616
Brain injury 16.53 9.95 45 149306 6998 63332673
Oromandibular dystonia 16.48 9.95 12 149339 515 63339156
Tension 16.47 9.95 28 149323 3147 63336524
Fall 16.46 9.95 1102 148249 391232 62948439
Lack of spontaneous speech 16.41 9.95 8 149343 161 63339510
Sputum discoloured 16.39 9.95 9 149342 16338 63323333
Persistent depressive disorder 16.36 9.95 16 149335 1034 63338637
Thyroid adenoma 16.32 9.95 8 149343 163 63339508
Arteriosclerosis coronary artery 16.28 9.95 50 149301 8323 63331348
Anaesthesia 16.15 9.95 11 149340 424 63339247
Illusion 16.11 9.95 16 149335 1054 63338617
Ascites 16.07 9.95 46 149305 40682 63298989
Craniosynostosis 16.06 9.95 8 149343 169 63339502
Injection site bruising 16.05 9.95 48 149303 41862 63297809
Bundle branch block right 16.05 9.95 36 149315 4962 63334709
Oculogyric crisis 16.00 9.95 20 149331 1701 63337970
Influenza 15.94 9.95 171 149180 108551 63231120
Blood bilirubin decreased 15.90 9.95 14 149337 791 63338880
Gait deviation 15.82 9.95 6 149345 63 63339608
Injection site warmth 15.77 9.95 8 149343 15187 63324484
Lupus hepatitis 15.76 9.95 5 149346 29 63339642
Facial nerve disorder 15.66 9.95 12 149339 557 63339114
Uveitis 15.65 9.95 5 149346 12548 63327123
Condition aggravated 15.62 9.95 780 148571 401437 62938234
Coordination abnormal 15.57 9.95 69 149282 13704 63325967
Vestibular disorder 15.55 9.95 18 149333 1413 63338258
Thyroxine free decreased 15.54 9.95 13 149338 685 63338986
Areflexia 15.52 9.95 27 149324 3091 63336580
Sleep disorder 15.52 9.95 274 149077 81292 63258379
Dyspraxia 15.50 9.95 9 149342 261 63339410
COVID-19 pneumonia 15.48 9.95 7 149344 14202 63325469
Macroglossia 15.43 9.95 13 149338 692 63338979
Melaena 15.41 9.95 30 149321 30335 63309336
Nausea 15.40 9.95 1768 147583 852703 62486968
Tongue discolouration 15.37 9.95 27 149324 3116 63336555
Cyclothymic disorder 15.26 9.95 6 149345 70 63339601
Cholestasis 15.24 9.95 120 149231 29314 63310357
Hypercapnic coma 15.18 9.95 8 149343 191 63339480
Toxicologic test abnormal 15.17 9.95 13 149338 708 63338963
Breast cancer stage III 15.14 9.95 3 149348 10383 63329288
Osteonecrosis of jaw 15.12 9.95 38 149313 35085 63304586
Pulmonary mass 15.11 9.95 98 149253 22498 63317173
Clonic convulsion 15.11 9.95 13 149338 712 63338959
Adrenal insufficiency 15.07 9.95 12 149339 17903 63321768
Victim of crime 15.07 9.95 7 149344 126 63339545
Cognitive disorder 15.06 9.95 199 149152 55616 63284055
Acute myeloid leukaemia 15.05 9.95 11 149340 17136 63322535
Fear of disease 14.86 9.95 17 149334 1317 63338354
Neurological examination normal 14.84 9.95 5 149346 36 63339635
Adjustment disorder with depressed mood 14.77 9.95 3 149348 10201 63329470
Foetal death 14.75 9.95 58 149293 10922 63328749
Morbid thoughts 14.70 9.95 12 149339 611 63339060
Neurological decompensation 14.67 9.95 24 149327 2614 63337057
Waxy flexibility 14.63 9.95 7 149344 135 63339536
Left ventricular hypertrophy 14.58 9.95 36 149315 5279 63334392
Congenital hand malformation 14.54 9.95 9 149342 294 63339377
Somatic symptom disorder 14.52 9.95 24 149327 2636 63337035
Muscle tightness 14.51 9.95 61 149290 11839 63327832
Taste disorder 14.47 9.95 7 149344 13655 63326016
Device difficult to use 14.43 9.95 6 149345 12790 63326881
Localised infection 14.35 9.95 31 149320 30179 63309492
Hyperventilation 14.28 9.95 39 149312 6077 63333594
Withdrawal catatonia 14.28 9.95 6 149345 84 63339587
Needle track marks 14.24 9.95 4 149347 14 63339657
Palmar-plantar erythrodysaesthesia syndrome 14.23 9.95 20 149331 22995 63316676
Choreoathetosis 14.22 9.95 11 149340 518 63339153
Heart rate decreased 14.19 9.95 57 149294 45503 63294168
Nervous system disorder 14.19 9.95 84 149267 18682 63320989
Atrioventricular septal defect 14.19 9.95 9 149342 307 63339364
Aspartate aminotransferase decreased 14.18 9.95 13 149338 775 63338896
Grip strength decreased 14.15 9.95 19 149332 22268 63317403
Impulsive behaviour 14.09 9.95 18 149333 1565 63338106
Blood sodium increased 14.05 9.95 24 149327 2708 63336963
Torticollis 14.05 9.95 20 149331 1929 63337742
Anticonvulsant drug level decreased 14.02 9.95 16 149335 1236 63338435
Perforation bile duct 14.02 9.95 4 149347 15 63339656
Alcohol abuse 13.98 9.95 21 149330 2125 63337546
Bradycardia 13.94 9.95 246 149105 72981 63266690
Sensation of foreign body 13.94 9.95 33 149318 4712 63334959
Newborn persistent pulmonary hypertension 13.93 9.95 8 149343 227 63339444
Lactate pyruvate ratio increased 13.90 9.95 6 149345 90 63339581
Drug-device interaction 13.90 9.95 6 149345 90 63339581
Formication 13.88 9.95 31 149320 4260 63335411
Gastric lavage 13.87 9.95 5 149346 45 63339626
Uterine enlargement 13.86 9.95 16 149335 1252 63338419
Hepatic cirrhosis 13.84 9.95 23 149328 24711 63314960
Tongue movement disturbance 13.81 9.95 9 149342 322 63339349
Brain oedema 13.76 9.95 68 149283 14127 63325544
Monoplegia 13.75 9.95 26 149325 3175 63336496
Asthenia 13.74 9.95 750 148601 382854 62956817
Foot deformity 13.72 9.95 28 149323 27825 63311846
Leukopenia 13.70 9.95 116 149235 77174 63262497
Abscess sterile 13.68 9.95 5 149346 47 63339624
Eye irritation 13.67 9.95 19 149332 21952 63317719
Unmasking of previously unidentified disease 13.61 9.95 14 149337 962 63338709
Musculoskeletal pain 13.58 9.95 145 149206 92132 63247539
Seizure cluster 13.53 9.95 8 149343 240 63339431
Skin necrosis 13.53 9.95 8 149343 13942 63325729
Toxic epidermal necrolysis 13.51 9.95 104 149247 25230 63314441
Myocarditis 13.44 9.95 54 149297 10271 63329400
Weight increased 13.41 9.95 490 148861 260302 63079369
Cardiac arrest neonatal 13.39 9.95 6 149345 99 63339572
Moaning 13.39 9.95 13 149338 833 63338838
Sciatica 13.37 9.95 39 149312 34285 63305386
Therapy interrupted 13.29 9.95 36 149315 32419 63307252
Liver disorder 13.29 9.95 73 149278 53614 63286057
Porphyria 13.28 9.95 7 149344 167 63339504
Labelled drug-food interaction issue 13.27 9.95 4 149347 19 63339652
Acidosis 13.25 9.95 57 149294 11176 63328495
Delusion of reference 13.23 9.95 6 149345 102 63339569
Pain in jaw 13.19 9.95 55 149296 43441 63296230
Hostility 13.18 9.95 19 149332 1853 63337818
Bruxism 13.17 9.95 27 149324 3498 63336173
Immunodeficiency 13.13 9.95 17 149334 20237 63319434
Delirium tremens 13.12 9.95 6 149345 104 63339567
Multiple-drug resistance 13.12 9.95 34 149317 5136 63334535
Exposure to unspecified agent 13.09 9.95 3 149348 3 63339668
Ulcer 13.07 9.95 26 149325 26081 63313590
Hyporeflexia 13.00 9.95 19 149332 1876 63337795
Hypertension 13.00 9.95 531 148820 278772 63060899
Blood lactate dehydrogenase increased 12.95 9.95 96 149255 23020 63316651
Petit mal epilepsy 12.94 9.95 28 149323 3766 63335905
Abortion spontaneous 12.91 9.95 62 149289 47133 63292538
Coeliac disease 12.89 9.95 7 149344 12790 63326881
Cellulitis 12.80 9.95 127 149224 81831 63257840
Intestinal infarction 12.76 9.95 14 149337 1036 63338635
Nervousness 12.73 9.95 120 149231 30859 63308812
Blood citric acid increased 12.67 9.95 5 149346 59 63339612
Implant site extravasation 12.60 9.95 10 149341 489 63339182
Hyperchloraemia 12.60 9.95 12 149339 751 63338920
Clostridium difficile colitis 12.59 9.95 18 149333 20551 63319120
Brief psychotic disorder with marked stressors 12.59 9.95 5 149346 60 63339611
Self-medication 12.57 9.95 23 149328 2740 63336931
Femur fracture 12.53 9.95 53 149298 41703 63297968
Progressive supranuclear palsy 12.52 9.95 5 149346 61 63339610
Cardiotoxicity 12.51 9.95 46 149305 8392 63331279
Radial nerve palsy 12.51 9.95 10 149341 494 63339177
Trismus 12.49 9.95 28 149323 3857 63335814
Blood pressure diastolic increased 12.46 9.95 4 149347 10006 63329665
Partial seizures 12.41 9.95 36 149315 5806 63333865
Gaze palsy 12.41 9.95 16 149335 1404 63338267
Clostridium difficile infection 12.40 9.95 33 149318 29889 63309782
Myoclonic epilepsy 12.35 9.95 15 149336 1239 63338432
Peritoneal perforation 12.34 9.95 6 149345 120 63339551
Paradoxical drug reaction 12.33 9.95 29 149322 4123 63335548
Apgar score low 12.32 9.95 12 149339 772 63338899
Metastases to liver 12.31 9.95 23 149328 23616 63316055
Victim of homicide 12.30 9.95 5 149346 64 63339607
Electrocardiogram ST segment elevation 12.29 9.95 28 149323 3899 63335772
Tonic clonic movements 12.27 9.95 16 149335 1419 63338252
Cholinergic syndrome 12.27 9.95 10 149341 508 63339163
Decreased interest 12.25 9.95 25 149326 3229 63336442
Premature labour 12.19 9.95 60 149291 12444 63327227
Blood prolactin increased 12.12 9.95 26 149325 3477 63336194
Substance use 12.12 9.95 10 149341 517 63339154
Hyperreflexia 12.07 9.95 36 149315 5898 63333773
Left ventricular dysfunction 12.03 9.95 58 149293 11930 63327741
Oxygen saturation abnormal 11.99 9.95 26 149325 3503 63336168
Haemophagocytic lymphohistiocytosis 11.95 9.95 5 149346 10622 63329049
Rectal haemorrhage 11.95 9.95 67 149284 48963 63290708
Dysphoria 11.93 9.95 32 149319 4934 63334737
Camptocormia 11.91 9.95 8 149343 301 63339370
Blood albumin increased 11.91 9.95 13 149338 956 63338715
Kidney enlargement 11.91 9.95 11 149340 662 63339009
Sedation complication 11.86 9.95 64 149287 13758 63325913
Poor sucking reflex 11.84 9.95 8 149343 304 63339367
Food allergy 11.84 9.95 6 149345 11395 63328276
Bacteraemia 11.83 9.95 14 149337 17334 63322337
Thrombotic microangiopathy 11.83 9.95 5 149346 10556 63329115
Drug dose titration not performed 11.82 9.95 10 149341 535 63339136
Renal failure 11.81 9.95 200 149151 117452 63222219
Severe myoclonic epilepsy of infancy 11.77 9.95 5 149346 72 63339599
Judgement impaired 11.72 9.95 12 149339 820 63338851
Periorbital swelling 11.68 9.95 23 149328 2895 63336776
Social anxiety disorder 11.67 9.95 9 149342 422 63339249
Pneumonitis 11.66 9.95 43 149308 35179 63304492
Reticulocytosis 11.58 9.95 6 149345 138 63339533
Drug level above therapeutic 11.58 9.95 31 149320 4774 63334897
Purpura senile 11.54 9.95 10 149341 553 63339118
Tuberculosis 11.49 9.95 6 149345 11205 63328466
Poverty of speech 11.48 9.95 8 149343 320 63339351
Theft 11.47 9.95 5 149346 77 63339594
Acute psychosis 11.46 9.95 21 149330 2504 63337167
Stevens-Johnson syndrome 11.46 9.95 99 149252 24851 63314820
Myofascial pain syndrome 11.45 9.95 20 149331 2298 63337373
Intervertebral disc disorder 11.43 9.95 31 149320 4812 63334859
Joint effusion 11.39 9.95 14 149337 17046 63322625
Head titubation 11.30 9.95 12 149339 856 63338815
Congenital nystagmus 11.29 9.95 3 149348 8 63339663
Snake bite 11.29 9.95 3 149348 8 63339663
Heart rate increased 11.28 9.95 296 149055 93942 63245729
Abdominal pain upper 11.27 9.95 385 148966 206059 63133612
Body mass index decreased 11.25 9.95 9 149342 445 63339226
Neonatal disorder 11.24 9.95 10 149341 573 63339098
Skin reaction 11.22 9.95 11 149340 14838 63324833
Muscle twitching 11.20 9.95 82 149269 19586 63320085
Dry skin 11.18 9.95 83 149268 56804 63282867
Persecutory delusion 11.17 9.95 22 149329 2768 63336903
Plasma cell myeloma 11.13 9.95 45 149306 35860 63303811
Poor venous access 11.12 9.95 11 149340 14774 63324897
Polyarthritis 11.05 9.95 5 149346 10141 63329530
Muscle contractions involuntary 10.99 9.95 20 149331 2372 63337299
Eczema eyelids 10.99 9.95 6 149345 154 63339517
Basophil count decreased 10.99 9.95 6 149345 154 63339517
Deformity 10.91 9.95 7 149344 11677 63327994
Hypercholesterolaemia 10.89 9.95 21 149330 21313 63318358
Brain operation 10.86 9.95 10 149341 599 63339072
Inguinal hernia 10.81 9.95 18 149333 1989 63337682
Pupil fixed 10.80 9.95 17 149334 1792 63337879
Strabismus 10.77 9.95 18 149333 1996 63337675
Gastrointestinal hypomotility 10.75 9.95 13 149338 1068 63338603
Sluggishness 10.75 9.95 32 149319 5237 63334434
Transfusion 10.68 9.95 12 149339 15205 63324466
Corrective lens user 10.68 9.95 7 149344 253 63339418
Quadriparesis 10.67 9.95 18 149333 2011 63337660
Anxiety disorder 10.65 9.95 27 149324 4023 63335648
Iris hyperpigmentation 10.63 9.95 4 149347 41 63339630
Transferrin saturation decreased 10.63 9.95 11 149340 761 63338910
Hepatitis cholestatic 10.63 9.95 38 149313 6840 63332831
Feeding intolerance 10.61 9.95 11 149340 763 63338908
Lower limb fracture 10.58 9.95 26 149325 24195 63315476
Ventricular arrhythmia 10.57 9.95 26 149325 3802 63335869
Breathing-related sleep disorder 10.57 9.95 5 149346 94 63339577
Frontotemporal dementia 10.56 9.95 8 149343 365 63339306
Pupillary reflex impaired 10.55 9.95 18 149333 2029 63337642
X-ray abnormal 10.53 9.95 3 149348 8107 63331564
Otospondylomegaepiphyseal dysplasia 10.52 9.95 5 149346 95 63339576
Therapy partial responder 10.49 9.95 6 149345 10652 63329019
Mitral valve disease 10.48 9.95 20 149331 2460 63337211
Epistaxis 10.41 9.95 115 149236 72610 63267061
Deafness neurosensory 10.40 9.95 30 149321 4825 63334846
Central nervous system stimulation 10.38 9.95 4 149347 44 63339627
Drug-induced liver injury 10.34 9.95 54 149297 40168 63299503
Chronic sinusitis 10.31 9.95 9 149342 12834 63326837
Breast cancer female 10.30 9.95 10 149341 13549 63326122
Blood alcohol increased 10.28 9.95 10 149341 642 63339029
Dermatitis atopic 10.27 9.95 5 149346 9719 63329952
Haemoperitoneum 10.25 9.95 21 149330 2720 63336951
Pseudoparalysis 10.22 9.95 4 149347 46 63339625
Electrocardiogram repolarisation abnormality 10.21 9.95 14 149337 1303 63338368
Hereditary angioedema 10.20 9.95 40 149311 7522 63332149
Poor quality sleep 10.17 9.95 81 149270 19854 63319817
Automatic bladder 10.15 9.95 5 149346 103 63339568
Labelled drug-disease interaction issue 10.15 9.95 4 149347 47 63339624
Mucosal erosion 10.12 9.95 15 149336 1501 63338170
Anticonvulsant drug level increased 10.11 9.95 15 149336 1502 63338169
Body temperature increased 10.09 9.95 49 149302 37143 63302528
Anaphylactic reaction 10.08 9.95 103 149248 65997 63273674
Lactic acidosis 10.07 9.95 51 149300 38236 63301435
Hypermagnesaemia 10.04 9.95 12 149339 974 63338697
Loss of libido 9.95 9.95 14 149337 1335 63338336

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug abuse 4275.70 11.17 3011 102530 96085 34755305
Toxicity to various agents 3768.18 11.17 3763 101778 196599 34654791
Coma 1209.06 11.17 1043 104498 44635 34806755
Overdose 990.28 11.17 1294 104247 89765 34761625
Drug dependence 913.54 11.17 681 104860 23536 34827854
Poisoning 882.98 11.17 516 105025 11710 34839680
Intentional overdose 779.90 11.17 802 104739 42872 34808518
Completed suicide 713.19 11.17 1153 104388 97015 34754375
Somnolence 634.14 11.17 1173 104368 109943 34741447
Intentional product misuse 611.95 11.17 721 104820 44890 34806500
Suicide attempt 595.17 11.17 660 104881 38456 34812934
Respiratory arrest 568.61 11.17 552 104989 27491 34823899
Miosis 551.07 11.17 349 105192 9186 34842204
Substance abuse 434.86 11.17 277 105264 7364 34844026
Respiratory depression 417.12 11.17 365 105176 15880 34835510
Poisoning deliberate 406.20 11.17 268 105273 7576 34843814
Aggression 365.29 11.17 516 105025 38448 34812942
Depressed level of consciousness 360.42 11.17 539 105002 42302 34809088
Accidental overdose 357.60 11.17 369 105172 19771 34831619
Agitation 350.98 11.17 625 104916 56774 34794616
Drug withdrawal syndrome 300.31 11.17 334 105207 19500 34831890
Cardio-respiratory arrest 292.91 11.17 566 104975 54707 34796683
Bradypnoea 271.42 11.17 144 105397 2685 34848705
Suicidal ideation 261.34 11.17 451 105090 39937 34811453
Sopor 259.28 11.17 246 105295 11890 34839500
Pneumonia aspiration 255.69 11.17 456 105085 41447 34809943
Diarrhoea 254.72 11.17 496 105045 389416 34461974
Febrile neutropenia 251.95 11.17 53 105488 136796 34714594
Intentional self-injury 234.89 11.17 247 105294 13524 34837866
Cardiac arrest 231.57 11.17 727 104814 95432 34755958
Asphyxia 226.30 11.17 178 105363 6657 34844733
Withdrawal syndrome 204.63 11.17 219 105322 12236 34839154
Drug interaction 204.37 11.17 1272 104269 224674 34626716
Sedation 200.93 11.17 281 105260 20725 34830665
Neuroleptic malignant syndrome 196.03 11.17 256 105285 17678 34833712
Altered state of consciousness 167.21 11.17 270 105271 22623 34828767
Anaemia 162.40 11.17 285 105256 233050 34618340
Dysarthria 160.04 11.17 336 105205 34446 34816944
Bradyphrenia 158.94 11.17 125 105416 4673 34846717
Mydriasis 153.24 11.17 146 105395 7091 34844299
Drug abuser 150.73 11.17 112 105429 3842 34847548
Restlessness 148.61 11.17 272 105269 25210 34826180
Coma scale abnormal 144.94 11.17 110 105431 3898 34847492
Drug use disorder 144.93 11.17 112 105429 4079 34847311
Visceral congestion 142.13 11.17 58 105483 572 34850818
Dyspnoea 131.22 11.17 639 104902 376143 34475247
Rash 129.40 11.17 302 105239 222450 34628940
Off label use 127.53 11.17 745 104796 418779 34432611
Pneumonia 123.36 11.17 620 104921 362007 34489383
Acute kidney injury 120.69 11.17 493 105048 304495 34546895
Disease progression 120.65 11.17 90 105451 107987 34743403
Prescription drug used without a prescription 119.83 11.17 77 105464 2077 34849313
Brain oedema 119.13 11.17 176 105365 13645 34837745
Malignant neoplasm progression 118.22 11.17 59 105482 87987 34763403
Loss of consciousness 113.85 11.17 523 105018 82144 34769246
Housebound 113.51 11.17 38 105503 200 34851190
Seizure 113.07 11.17 619 104922 104238 34747152
Anxiety 112.67 11.17 595 104946 98833 34752557
Logorrhoea 109.15 11.17 76 105465 2350 34849040
Abnormal behaviour 108.84 11.17 236 105305 24733 34826657
Psychotic disorder 108.74 11.17 233 105308 24219 34827171
Hypothermia 107.59 11.17 147 105394 10601 34840789
Arthralgia 107.37 11.17 220 105321 169821 34681569
COVID-19 107.10 11.17 50 105491 77500 34773890
Cough 106.48 11.17 181 105360 149959 34701431
Accidental death 105.99 11.17 75 105466 2381 34849009
Thrombocytopenia 105.72 11.17 194 105347 156053 34695337
Sepsis 105.58 11.17 215 105326 166346 34685044
Confusional state 103.34 11.17 767 104774 143393 34707997
Salivary hypersecretion 101.69 11.17 128 105413 8516 34842874
Delirium 98.82 11.17 325 105216 43666 34807724
Pulmonary congestion 97.32 11.17 160 105381 13605 34837785
Fatigue 97.27 11.17 688 104853 369965 34481425
Pulmonary oedema 96.11 11.17 339 105202 47190 34804200
Nausea 94.08 11.17 621 104920 339287 34512103
Alcohol poisoning 92.72 11.17 81 105460 3512 34847878
Pancytopenia 91.86 11.17 91 105450 95066 34756324
Atrial fibrillation 89.12 11.17 145 105396 122248 34729142
Extrapyramidal disorder 88.75 11.17 148 105393 12732 34838658
Disturbance in attention 88.74 11.17 223 105318 25722 34825668
Cardiac failure congestive 88.29 11.17 73 105468 83197 34768193
Drug screen positive 88.17 11.17 82 105459 3861 34847529
Interstitial lung disease 84.27 11.17 46 105495 65236 34786154
Delusion 78.93 11.17 139 105402 12496 34838894
Electrocardiogram QT prolonged 78.45 11.17 287 105254 40665 34810725
Pyrexia 76.98 11.17 640 104901 332373 34519017
Drug detoxification 74.88 11.17 29 105512 246 34851144
Abdominal pain 73.33 11.17 251 105290 163367 34688023
Rhabdomyolysis 73.15 11.17 402 105139 67761 34783629
Dystonia 72.57 11.17 123 105418 10722 34840668
Tachycardia 71.82 11.17 470 105071 84302 34767088
General physical health deterioration 71.11 11.17 178 105363 128091 34723299
Suicidal behaviour 69.94 11.17 48 105493 1449 34849941
Prostate cancer 69.58 11.17 17 105524 39632 34811758
Joint swelling 69.24 11.17 48 105493 59842 34791548
Product dose omission issue 68.82 11.17 163 105378 119548 34731842
Psychomotor hyperactivity 68.22 11.17 112 105429 9510 34841880
Disorientation 68.18 11.17 238 105303 32950 34818440
Mental impairment 67.66 11.17 116 105425 10206 34841184
Thinking abnormal 67.66 11.17 88 105453 6049 34845341
Infusion related reaction 67.59 11.17 38 105503 53019 34798371
Alcohol abuse 67.57 11.17 77 105464 4613 34846777
Bradykinesia 66.67 11.17 70 105471 3823 34847567
Peripheral swelling 66.34 11.17 80 105461 76461 34774929
Exposure via ingestion 66.22 11.17 54 105487 2127 34849263
Aspiration 65.88 11.17 126 105415 12068 34839322
Akathisia 65.23 11.17 100 105441 8009 34843381
Dyspnoea exertional 64.38 11.17 25 105516 43254 34808136
Haemoglobin decreased 64.32 11.17 171 105370 120601 34730789
Pruritus 64.15 11.17 217 105324 141764 34709626
Platelet count decreased 64.15 11.17 169 105372 119548 34731842
Weight decreased 63.44 11.17 295 105246 176006 34675384
Mood swings 62.95 11.17 97 105444 7804 34843586
Irritability 60.52 11.17 188 105353 24502 34826888
Hypertonia 59.97 11.17 69 105472 4177 34847213
Hypoventilation 59.57 11.17 62 105479 3352 34848038
Status epilepticus 59.32 11.17 123 105418 12491 34838899
Arteriosclerosis coronary artery 59.02 11.17 122 105419 12363 34839027
Ascites 58.39 11.17 34 105507 46537 34804853
Drug withdrawal syndrome neonatal 58.31 11.17 63 105478 3556 34847834
Sudden death 57.67 11.17 136 105405 15065 34836325
Renal impairment 57.30 11.17 125 105416 94388 34757002
Rheumatoid arthritis 57.02 11.17 22 105519 38216 34813174
Serotonin syndrome 56.68 11.17 160 105381 19773 34831617
Panic attack 56.64 11.17 102 105439 9330 34842060
Mucosal inflammation 56.31 11.17 23 105518 38599 34812791
Pleural effusion 56.21 11.17 100 105441 81446 34769944
Depression 56.09 11.17 492 105049 96606 34754784
Anger 56.03 11.17 116 105425 11768 34839622
Nystagmus 55.74 11.17 70 105471 4645 34846745
Drug withdrawal convulsions 55.61 11.17 38 105503 1139 34850251
Sinus tachycardia 55.00 11.17 145 105396 17215 34834175
Antipsychotic drug level increased 54.91 11.17 63 105478 3802 34847588
Oedema peripheral 54.87 11.17 182 105359 119630 34731760
Alcohol interaction 54.63 11.17 55 105486 2858 34848532
Schizophrenia 53.69 11.17 95 105446 8571 34842819
Nasopharyngitis 53.65 11.17 80 105461 69888 34781502
Epilepsy 52.98 11.17 164 105377 21331 34830059
Tremor 52.74 11.17 428 105113 82159 34769231
Psychotic symptom 52.60 11.17 43 105498 1700 34849690
Toxicologic test abnormal 52.48 11.17 28 105513 528 34850862
Postmortem blood drug level abnormal 52.23 11.17 23 105518 278 34851112
Product use in unapproved indication 52.10 11.17 181 105360 117318 34734072
Neutropenia 50.84 11.17 272 105269 156506 34694884
Paranoia 50.23 11.17 112 105429 11956 34839434
Asthenia 50.13 11.17 486 105055 244765 34606625
Drug intolerance 49.79 11.17 64 105477 59506 34791884
Infection 49.71 11.17 127 105414 90788 34760602
Gastrointestinal haemorrhage 49.62 11.17 122 105419 88355 34763035
International normalised ratio increased 49.51 11.17 42 105499 47285 34804105
Haematochezia 49.05 11.17 41 105500 46493 34804897
Decreased appetite 48.94 11.17 298 105243 166094 34685296
Insomnia 48.83 11.17 504 105037 103403 34747987
Echolalia 48.53 11.17 22 105519 286 34851104
Cytomegalovirus infection 48.27 11.17 10 105531 26125 34825265
Epistaxis 47.23 11.17 64 105477 58187 34793203
Stomatitis 46.63 11.17 36 105505 42478 34808912
Generalised tonic-clonic seizure 46.25 11.17 155 105386 21019 34830371
Accidental poisoning 45.83 11.17 29 105512 761 34850629
Self-injurious ideation 45.55 11.17 39 105502 1645 34849745
Unresponsive to stimuli 45.24 11.17 184 105357 27385 34824005
Cerebrovascular accident 45.20 11.17 120 105421 84691 34766699
Erythema 44.06 11.17 130 105411 88650 34762740
Psychotic behaviour 43.58 11.17 27 105514 682 34850708
Coordination abnormal 42.54 11.17 80 105461 7564 34843826
Drug ineffective 42.23 11.17 1054 104487 455697 34395693
Mental disorder 42.19 11.17 121 105420 15088 34836302
Pneumocystis jirovecii pneumonia 42.14 11.17 5 105536 19705 34831685
Persecutory delusion 41.72 11.17 45 105496 2535 34848855
Self-medication 41.72 11.17 46 105495 2657 34848733
Chills 41.44 11.17 117 105424 80926 34770464
Behaviour disorder 40.13 11.17 61 105480 4849 34846541
Cytokine release syndrome 39.76 11.17 10 105531 22867 34828523
Inappropriate schedule of product administration 39.75 11.17 80 105461 62216 34789174
Pneumonitis 39.35 11.17 27 105514 33851 34817539
Bladder dilatation 39.23 11.17 34 105507 1458 34849932
Depressed mood 39.21 11.17 138 105403 19179 34832211
Memory impairment 39.01 11.17 244 105297 43074 34808316
Tension 38.85 11.17 40 105501 2135 34849255
Hypotonia 38.61 11.17 78 105463 7775 34843615
Dehydration 38.60 11.17 232 105309 129737 34721653
Blood pressure fluctuation 38.52 11.17 14 105527 25235 34826155
Drug diversion 38.29 11.17 27 105514 852 34850538
Ataxia 38.22 11.17 110 105431 13743 34837647
Colitis 37.68 11.17 35 105506 37715 34813675
Hallucination, auditory 37.20 11.17 99 105442 11818 34839572
Blood pressure increased 36.86 11.17 139 105402 87963 34763427
Hypoxic-ischaemic encephalopathy 36.61 11.17 56 105485 4476 34846914
Muscle rigidity 36.58 11.17 91 105450 10427 34840963
Myocardial infarction 36.55 11.17 215 105326 120870 34730520
Plasma cell myeloma 36.34 11.17 44 105497 41993 34809397
Acute myeloid leukaemia 35.86 11.17 6 105535 18264 34833126
Emotional disorder 35.85 11.17 63 105478 5653 34845737
Parkinsonism 35.54 11.17 77 105464 8061 34843329
Opiates positive 35.40 11.17 22 105519 559 34850831
Neuropathy peripheral 35.07 11.17 131 105410 83132 34768258
Tumour lysis syndrome 34.85 11.17 5 105536 17054 34834336
Encephalitis toxic 34.41 11.17 17 105524 271 34851119
Haematuria 33.94 11.17 62 105479 50004 34801386
Cardiac failure 33.77 11.17 151 105390 91097 34760293
Renal failure 33.25 11.17 244 105297 130313 34721077
Bronchopulmonary aspergillosis 33.19 11.17 3 105538 14656 34836734
Blood pressure systolic increased 32.92 11.17 14 105527 22938 34828452
Nightmare 32.90 11.17 107 105434 14284 34837106
COVID-19 pneumonia 32.37 11.17 6 105535 16961 34834429
Hyperhidrosis 32.21 11.17 360 105181 75332 34776058
Homicide 32.02 11.17 25 105516 924 34850466
Palmar-plantar erythrodysaesthesia syndrome 31.91 11.17 6 105535 16789 34834601
Chronic kidney disease 31.69 11.17 47 105494 41163 34810227
Chest discomfort 31.50 11.17 74 105467 54456 34796934
Injection site pain 31.47 11.17 43 105498 38962 34812428
Brain injury 31.39 11.17 62 105479 6080 34845310
Angioedema 31.38 11.17 40 105501 37334 34814056
Product communication issue 31.26 11.17 18 105523 396 34850994
Acute myocardial infarction 30.95 11.17 73 105468 53646 34797744
Vestibular disorder 30.68 11.17 26 105515 1081 34850309
Agoraphobia 30.48 11.17 15 105526 237 34851153
Postmortem blood drug level increased 30.37 11.17 15 105526 239 34851151
Thrombosis 30.34 11.17 67 105474 50391 34800999
Dizziness 30.19 11.17 471 105070 218050 34633340
Dependence 29.82 11.17 26 105515 1124 34850266
Asthma 29.66 11.17 52 105489 42604 34808786
Pain in extremity 29.61 11.17 242 105299 126271 34725119
Blood creatine phosphokinase increased 29.44 11.17 234 105307 44623 34806767
Amnesia 29.37 11.17 158 105383 26405 34824985
Poor quality sleep 29.31 11.17 72 105469 8184 34843206
Arthropathy 29.23 11.17 23 105518 26884 34824506
Anterograde amnesia 29.03 11.17 13 105528 164 34851226
Hypomagnesaemia 28.77 11.17 15 105526 21836 34829554
Myelodysplastic syndrome 28.72 11.17 11 105530 19197 34832193
Stiff person syndrome 28.64 11.17 11 105530 91 34851299
Respiratory acidosis 28.29 11.17 53 105488 4997 34846393
Nervousness 28.16 11.17 93 105448 12513 34838877
Treatment failure 28.08 11.17 62 105479 46635 34804755
Clostridium difficile infection 27.96 11.17 11 105530 18887 34832503
Acute psychosis 27.81 11.17 31 105510 1812 34849578
Treatment noncompliance 27.66 11.17 162 105379 27938 34823452
Cerebral congestion 27.43 11.17 8 105533 24 34851366
Productive cough 27.29 11.17 45 105496 37768 34813622
Myelosuppression 27.23 11.17 12 105529 19253 34832137
Muscle spasticity 27.20 11.17 57 105484 5831 34845559
Bone marrow failure 27.04 11.17 29 105512 29224 34822166
Necrotising colitis 27.02 11.17 24 105517 1064 34850326
Urticaria 27.01 11.17 97 105444 62280 34789110
Sedation complication 27.01 11.17 30 105511 1747 34849643
Arthritis 26.89 11.17 33 105508 31313 34820077
Pupillary disorder 26.89 11.17 15 105526 310 34851080
Hypervolaemia 26.74 11.17 13 105528 19696 34831694
Pulmonary fibrosis 26.74 11.17 11 105530 18385 34833005
Cerebral haemorrhage 26.72 11.17 40 105501 34897 34816493
Electroencephalogram abnormal 26.49 11.17 35 105506 2443 34848947
Victim of chemical submission 26.04 11.17 9 105532 53 34851337
Abdominal distension 25.97 11.17 90 105451 58402 34792988
Facial spasm 25.83 11.17 13 105528 216 34851174
Homicidal ideation 25.81 11.17 36 105505 2646 34848744
Herpes zoster 25.71 11.17 40 105501 34359 34817031
Wheezing 25.70 11.17 54 105487 41348 34810042
Electrolyte imbalance 25.63 11.17 6 105535 14406 34836984
Rectal haemorrhage 25.40 11.17 52 105489 40197 34811193
Abdominal discomfort 25.28 11.17 94 105447 59741 34791649
Oral discharge 25.27 11.17 11 105530 129 34851261
Hallucination 25.22 11.17 252 105289 51246 34800144
Hospitalisation 24.96 11.17 88 105453 56814 34794576
Hypocalcaemia 24.86 11.17 22 105519 24267 34827123
Spleen congestion 24.60 11.17 14 105527 301 34851089
Victim of crime 24.60 11.17 15 105526 368 34851022
Rash pruritic 24.58 11.17 27 105514 26914 34824476
Fluid retention 24.47 11.17 27 105514 26860 34824530
Blood creatinine increased 24.41 11.17 177 105364 94799 34756591
Inadequate analgesia 24.37 11.17 37 105504 2938 34848452
Blepharospasm 24.17 11.17 23 105518 1115 34850275
Tubulointerstitial nephritis 24.09 11.17 17 105524 21007 34830383
Neoplasm progression 23.97 11.17 21 105520 23279 34828111
Osteonecrosis of jaw 23.97 11.17 12 105529 17877 34833513
Sexual abuse 23.93 11.17 11 105530 148 34851242
Penis injury 23.86 11.17 13 105528 256 34851134
Mania 23.84 11.17 73 105468 9438 34841952
Melaena 23.81 11.17 44 105497 35336 34816054
Basal cell carcinoma 23.73 11.17 15 105526 19643 34831747
Abnormal dreams 23.70 11.17 63 105478 7515 34843875
Fatty liver alcoholic 23.48 11.17 9 105532 74 34851316
Breech presentation 23.48 11.17 11 105530 155 34851235
Basilar migraine 23.36 11.17 6 105535 9 34851381
Dyskinesia 23.22 11.17 131 105410 22282 34829108
Cytopenia 23.22 11.17 5 105536 12718 34838672
Psychomotor skills impaired 23.14 11.17 42 105499 3864 34847526
Hanging 22.98 11.17 11 105530 163 34851227
Full blood count decreased 22.96 11.17 13 105528 18075 34833315
Full blood count abnormal 22.87 11.17 14 105527 18654 34832736
Suicide threat 22.66 11.17 7 105534 27 34851363
White blood cell count decreased 22.59 11.17 182 105359 95263 34756127
Bacteraemia 22.52 11.17 16 105525 19701 34831689
Catatonia 22.46 11.17 48 105493 4977 34846413
Patient restraint 22.30 11.17 9 105532 86 34851304
Psoriasis 22.15 11.17 53 105488 38759 34812631
Diet refusal 22.14 11.17 13 105528 297 34851093
Blood alcohol increased 22.14 11.17 19 105522 804 34850586
Osmolar gap abnormal 22.08 11.17 7 105534 30 34851360
Cataract 22.01 11.17 28 105513 26158 34825232
Anaphylactic reaction 21.89 11.17 40 105501 32261 34819129
Hepatocellular injury 21.82 11.17 128 105413 22083 34829307
Abdominal pain upper 21.52 11.17 127 105414 71363 34780027
Pancreatitis 21.49 11.17 54 105487 38837 34812553
Crystalluria 21.48 11.17 15 105526 466 34850924
Cardiomegaly 21.45 11.17 98 105443 15340 34836050
Stereotypy 21.41 11.17 18 105523 740 34850650
Transplant rejection 21.12 11.17 3 105538 10308 34841082
Drug withdrawal maintenance therapy 21.03 11.17 9 105532 101 34851289
Libido disorder 20.96 11.17 12 105529 261 34851129
Reflexes abnormal 20.82 11.17 13 105528 333 34851057
Congestive hepatopathy 20.78 11.17 27 105514 1854 34849536
Sleep disorder 20.62 11.17 165 105376 31523 34819867
Reaction to excipient 20.56 11.17 15 105526 500 34850890
Apnoea 20.44 11.17 55 105486 6609 34844781
Pulmonary contusion 20.34 11.17 8 105533 71 34851319
Coronary artery disease 20.33 11.17 76 105465 48229 34803161
Claustrophobia 20.29 11.17 12 105529 278 34851112
Needle track marks 20.29 11.17 7 105534 41 34851349
Bladder cancer 20.23 11.17 12 105529 16266 34835124
Dissociation 20.22 11.17 25 105516 1633 34849757
Portal tract inflammation 20.15 11.17 8 105533 73 34851317
Metastases to liver 20.13 11.17 8 105533 13655 34837735
Substance abuser 20.13 11.17 9 105532 113 34851277
Hyperthermia 20.13 11.17 74 105467 10503 34840887
Inflammation 20.12 11.17 34 105507 28261 34823129
Dry skin 20.10 11.17 40 105501 31247 34820143
Illusion 20.05 11.17 18 105523 809 34850581
Loss of personal independence in daily activities 19.99 11.17 44 105497 33135 34818255
Personal relationship issue 19.84 11.17 12 105529 290 34851100
Hypercapnic coma 19.83 11.17 10 105531 167 34851223
Leukopenia 19.82 11.17 110 105431 62746 34788644
Frequent bowel movements 19.66 11.17 7 105534 12780 34838610
Penile haemorrhage 19.60 11.17 16 105525 631 34850759
Drug level increased 19.60 11.17 124 105417 21972 34829418
Opisthotonus 19.55 11.17 14 105527 453 34850937
Schizoaffective disorder 19.48 11.17 22 105519 1305 34850085
Somnambulism 19.45 11.17 34 105507 3038 34848352
Prostatic specific antigen increased 19.44 11.17 10 105531 14670 34836720
Colitis ulcerative 19.40 11.17 13 105528 16507 34834883
Incoherent 19.30 11.17 42 105499 4410 34846980
Blood uric acid increased 19.25 11.17 3 105538 9621 34841769
Therapeutic response decreased 19.25 11.17 37 105504 29276 34822114
Condition aggravated 19.17 11.17 438 105103 191758 34659632
Alcoholism 19.01 11.17 33 105508 2932 34848458
Hyperammonaemia 18.98 11.17 52 105489 6315 34845075
Accident 18.97 11.17 45 105496 5002 34846388
Lymphoma 18.97 11.17 7 105534 12500 34838890
Swelling 18.93 11.17 65 105476 42301 34809089
Diabetes mellitus 18.92 11.17 75 105466 46798 34804592
Respiratory rate decreased 18.84 11.17 29 105512 2330 34849060
Road traffic accident 18.75 11.17 103 105438 17347 34834043
Back pain 18.70 11.17 257 105284 121532 34729858
Hallucinations, mixed 18.66 11.17 31 105510 2658 34848732
Affect lability 18.60 11.17 37 105504 3646 34847744
Angina pectoris 18.56 11.17 42 105499 31321 34820069
Deep vein thrombosis 18.55 11.17 118 105423 65130 34786260
Inappropriate antidiuretic hormone secretion 18.50 11.17 82 105459 12671 34838719
Persistent depressive disorder 18.50 11.17 12 105529 329 34851061
Haemophagocytic lymphohistiocytosis 18.47 11.17 8 105533 12965 34838425
Skin ulcer 18.42 11.17 24 105517 22192 34829198
Stupor 18.30 11.17 32 105509 2859 34848531
Neutrophil count increased 18.28 11.17 101 105440 17045 34834345
Social anxiety disorder 18.21 11.17 12 105529 338 34851052
Priapism 18.20 11.17 44 105497 4950 34846440
Cellulitis 18.18 11.17 90 105451 52861 34798529
Impaired self-care 18.17 11.17 21 105520 1277 34850113
Mobility decreased 18.11 11.17 40 105501 30088 34821302
Liver disorder 18.09 11.17 46 105495 32951 34818439
Hyperglycaemia 18.03 11.17 60 105481 39420 34811970
Ejaculation delayed 18.00 11.17 11 105530 271 34851119
Drug hypersensitivity 17.94 11.17 156 105385 80373 34771017
Septic shock 17.91 11.17 135 105406 71699 34779691
Cardiopulmonary failure 17.85 11.17 39 105502 4106 34847284
Upper gastrointestinal haemorrhage 17.83 11.17 31 105510 25487 34825903
Mucosal erosion 17.81 11.17 17 105524 827 34850563
Slow speech 17.77 11.17 20 105521 1182 34850208
Hostility 17.74 11.17 17 105524 831 34850559
Muscular weakness 17.71 11.17 138 105403 72759 34778631
Medication error 17.68 11.17 135 105406 25430 34825960
Bradycardia 17.67 11.17 323 105218 75095 34776295
Nephrolithiasis 17.64 11.17 41 105500 30292 34821098
Hyperbilirubinaemia 17.55 11.17 15 105526 16828 34834562
Subacute endocarditis 17.52 11.17 7 105534 65 34851325
Bone pain 17.51 11.17 22 105519 20664 34830726
Obsessive thoughts 17.46 11.17 16 105525 739 34850651
Personality change 17.38 11.17 44 105497 5095 34846295
Sensory integrative dysfunction 17.27 11.17 6 105535 36 34851354
Diverticulitis 17.22 11.17 21 105520 19983 34831407
Substance use disorder 17.03 11.17 16 105525 763 34850627
Hepatotoxicity 17.01 11.17 24 105517 21461 34829929
Skin lesion 16.93 11.17 25 105516 21936 34829454
Ileus paralytic 16.91 11.17 48 105493 5949 34845441
Emotional disorder of childhood 16.86 11.17 6 105535 39 34851351
Pathogen resistance 16.76 11.17 4 105537 9478 34841912
Intentional product use issue 16.58 11.17 109 105432 59707 34791683
Rebound psychosis 16.58 11.17 9 105532 176 34851214
Fear 16.46 11.17 69 105472 10407 34840983
Pain threshold decreased 16.45 11.17 5 105536 18 34851372
Tuberculosis 16.43 11.17 3 105538 8574 34842816
Hangover 16.42 11.17 18 105523 1033 34850357
Flushing 16.41 11.17 47 105494 32373 34819017
Sluggishness 16.37 11.17 33 105508 3284 34848106
Clumsiness 16.30 11.17 23 105518 1709 34849681
Oesophageal carcinoma 16.30 11.17 4 105537 9300 34842090
White blood cell count increased 16.27 11.17 193 105348 40958 34810432
Rhesus incompatibility 16.25 11.17 6 105535 44 34851346
Aspartate aminotransferase increased 16.15 11.17 129 105412 67654 34783736
Lymphadenopathy 16.13 11.17 39 105502 28424 34822966
Metastases to bone 16.08 11.17 8 105533 11962 34839428
Infantile apnoea 15.96 11.17 17 105524 944 34850446
Graft versus host disease 15.89 11.17 6 105535 10563 34840827
Faecal disimpaction 15.85 11.17 5 105536 21 34851369
Psoriatic arthropathy 15.79 11.17 22 105519 19776 34831614
Blood pressure diastolic decreased 15.75 11.17 4 105537 9090 34842300
Bradycardia neonatal 15.74 11.17 17 105524 959 34850431
Movement disorder 15.74 11.17 76 105465 12172 34839218
Myocardial depression 15.58 11.17 6 105535 50 34851340
Blunted affect 15.55 11.17 11 105530 349 34851041
Myocarditis 15.54 11.17 82 105459 13600 34837790
Apathy 15.36 11.17 51 105490 6881 34844509
Adverse drug reaction 15.25 11.17 42 105499 29300 34822090
Ex-drug abuser 15.23 11.17 8 105533 146 34851244
Daydreaming 15.21 11.17 13 105528 547 34850843
Chronic obstructive pulmonary disease 15.20 11.17 86 105455 48832 34802558
Hyperkalaemia 15.20 11.17 135 105406 69254 34782136
Congenital pulmonary valve atresia 15.18 11.17 6 105535 54 34851336
Antipsychotic drug level decreased 15.17 11.17 17 105524 1000 34850390
Electrocardiogram PR prolongation 15.16 11.17 16 105525 879 34850511
Prescription form tampering 15.13 11.17 12 105529 454 34850936
Myofascial pain syndrome 15.09 11.17 11 105530 366 34851024
Squamous cell carcinoma of skin 15.03 11.17 7 105534 10874 34840516
Oedema 14.99 11.17 79 105462 45662 34805728
Femoral nerve palsy 14.99 11.17 6 105535 56 34851334
Drug tolerance increased 14.91 11.17 12 105529 464 34850926
Mood altered 14.88 11.17 60 105481 8892 34842498
Coma acidotic 14.85 11.17 4 105537 8 34851382
Product counterfeit 14.85 11.17 8 105533 154 34851236
Toxic encephalopathy 14.79 11.17 42 105499 5207 34846183
Hyperreflexia 14.77 11.17 31 105510 3175 34848215
Rhinorrhoea 14.68 11.17 35 105506 25633 34825757
Neutropenic sepsis 14.66 11.17 12 105529 13755 34837635
Pneumoconiosis 14.64 11.17 9 105532 224 34851166
Multiple organ dysfunction syndrome 14.64 11.17 154 105387 76412 34774978
Polyneuropathy 14.64 11.17 14 105527 14882 34836508
Disinhibition 14.63 11.17 31 105510 3195 34848195
Sciatic nerve neuropathy 14.63 11.17 6 105535 60 34851330
Hypersensitivity 14.61 11.17 116 105425 60919 34790471
Autonomic nervous system imbalance 14.57 11.17 27 105514 2524 34848866
Staring 14.55 11.17 20 105521 1450 34849940
Poverty of speech 14.54 11.17 9 105532 227 34851163
Anticonvulsant drug level increased 14.53 11.17 21 105520 1595 34849795
Haemorrhage intracranial 14.52 11.17 16 105525 15930 34835460
Forearm fracture 14.49 11.17 7 105534 106 34851284
Thrombotic microangiopathy 14.44 11.17 7 105534 10623 34840767
Blood bilirubin increased 14.38 11.17 63 105478 38233 34813157
Neutrophil count decreased 14.23 11.17 93 105448 51011 34800379
Hypogammaglobulinaemia 14.21 11.17 3 105538 7737 34843653
Learning disorder 14.19 11.17 17 105524 1074 34850316
Blood phosphorus increased 14.16 11.17 3 105538 7718 34843672
Acidosis 14.12 11.17 68 105473 10877 34840513
Crime 14.05 11.17 6 105535 67 34851323
Laboratory test abnormal 14.04 11.17 25 105516 20366 34831024
Haematocrit decreased 14.01 11.17 50 105491 32166 34819224
Drug level below therapeutic 13.98 11.17 43 105498 5572 34845818
Impaired driving ability 13.97 11.17 27 105514 2606 34848784
Hypertension 13.86 11.17 310 105231 136133 34715257
Paradoxical drug reaction 13.83 11.17 31 105510 3320 34848070
Aura 13.74 11.17 10 105531 332 34851058
Selective mutism 13.74 11.17 6 105535 71 34851319
Skull fractured base 13.73 11.17 8 105533 180 34851210
Physical abuse 13.71 11.17 4 105537 12 34851378
Electrocardiogram J wave 13.71 11.17 4 105537 12 34851378
Speech disorder 13.70 11.17 128 105413 25558 34825832
Syncope 13.67 11.17 194 105347 91257 34760133
Violence-related symptom 13.66 11.17 12 105529 524 34850866
Neuromuscular toxicity 13.59 11.17 6 105535 73 34851317
Vascular stenosis 13.58 11.17 8 105533 184 34851206
Localised infection 13.58 11.17 20 105521 17567 34833823
Haemorrhage 13.55 11.17 95 105446 51275 34800115
Physical assault 13.54 11.17 17 105524 1128 34850262
Blood ketone body increased 13.52 11.17 11 105530 432 34850958
Myositis 13.51 11.17 10 105531 12060 34839330
Chemical poisoning 13.51 11.17 7 105534 124 34851266
Hyponatraemic coma 13.50 11.17 5 105536 37 34851353
Febrile bone marrow aplasia 13.49 11.17 4 105537 8205 34843185
Post-traumatic stress disorder 13.47 11.17 22 105519 1859 34849531
Alcohol intolerance 13.45 11.17 11 105530 435 34850955
Myalgia 13.45 11.17 176 105365 83934 34767456
Drug tolerance 13.43 11.17 28 105513 2854 34848536
Affective disorder 13.38 11.17 36 105505 4324 34847066
Eosinophilic myocarditis 13.36 11.17 12 105529 540 34850850
Appendicitis 13.33 11.17 15 105526 14792 34836598
Therapy interrupted 13.31 11.17 13 105528 13684 34837706
Protrusion tongue 13.31 11.17 8 105533 191 34851199
Diffuse large B-cell lymphoma 13.24 11.17 3 105538 7367 34844023
Urinary incontinence 13.23 11.17 100 105441 18774 34832616
Lung neoplasm malignant 13.22 11.17 20 105521 17375 34834015
Hypothyroidism 13.19 11.17 27 105514 20875 34830515
Lymphopenia 13.18 11.17 18 105523 16317 34835073
Erectile dysfunction 13.18 11.17 107 105434 20530 34830860
Neoplasm malignant 13.18 11.17 25 105516 19880 34831510
Family stress 13.17 11.17 7 105534 131 34851259
Antasthmatic drug level 13.16 11.17 5 105536 40 34851350
Social avoidant behaviour 13.07 11.17 29 105512 3085 34848305
Clostridium difficile colitis 13.03 11.17 17 105524 15713 34835677
Suspected suicide attempt 13.03 11.17 7 105534 134 34851256
Influenza 13.02 11.17 92 105449 49574 34801816
Haemoptysis 12.90 11.17 58 105483 34948 34816442
Analgesic drug level 12.85 11.17 5 105536 43 34851347
Hepatitis cholestatic 12.83 11.17 4 105537 7943 34843447
Herbal interaction 12.82 11.17 10 105531 369 34851021
Accident at work 12.82 11.17 14 105527 800 34850590
Colon cancer 12.78 11.17 5 105536 8616 34842774
Substance dependence 12.73 11.17 10 105531 373 34851017
Dyssomnia 12.65 11.17 5 105536 45 34851345
Bacterial infection 12.60 11.17 20 105521 17043 34834347
Therapeutic product effect incomplete 12.59 11.17 95 105446 50446 34800944
Muscle twitching 12.59 11.17 63 105478 10235 34841155
Antipsychotic drug level above therapeutic 12.54 11.17 17 105524 1216 34850174
Injury 12.54 11.17 106 105435 20581 34830809
Hypophosphataemia 12.52 11.17 9 105532 11017 34840373
Foetal distress syndrome 12.48 11.17 16 105525 1084 34850306
CSF lymphocyte count increased 12.35 11.17 3 105538 3 34851387
Cerebral infarction 12.35 11.17 42 105499 27413 34823977
Panic disorder 12.32 11.17 17 105524 1237 34850153
Judgement impaired 12.30 11.17 12 105529 600 34850790
Dyspepsia 12.29 11.17 63 105478 36669 34814721
Potentiating drug interaction 12.28 11.17 38 105503 4939 34846451
Analgesic drug level above therapeutic 12.23 11.17 9 105532 304 34851086
Delusional disorder, unspecified type 12.20 11.17 13 105528 722 34850668
Xanthelasma 12.18 11.17 6 105535 95 34851295
Nephropathy toxic 12.18 11.17 12 105529 12576 34838814
Sexually inappropriate behaviour 12.13 11.17 11 105530 501 34850889
Oral pain 12.08 11.17 9 105532 10818 34840572
Neurosis 12.08 11.17 7 105534 156 34851234
Refusal of treatment by patient 12.03 11.17 38 105503 4994 34846396
Hepatic cytolysis 12.03 11.17 80 105461 14416 34836974
Multiple-drug resistance 12.02 11.17 39 105502 5200 34846190
Delirium tremens 12.01 11.17 12 105529 618 34850772
Communication disorder 11.98 11.17 25 105516 2549 34848841
Carbon monoxide poisoning 11.96 11.17 6 105535 99 34851291
Hyperacusis 11.92 11.17 14 105527 866 34850524
Respiratory distress 11.86 11.17 162 105379 35503 34815887
Atrial septal defect 11.86 11.17 49 105492 7343 34844047
Sciatic nerve injury 11.85 11.17 6 105535 101 34851289
Bezoar 11.84 11.17 16 105525 1141 34850249
Osteomyelitis 11.83 11.17 19 105522 16117 34835273
Alopecia 11.83 11.17 36 105505 24319 34827071
Adrenal insufficiency 11.82 11.17 15 105526 14032 34837358
Uveitis 11.80 11.17 4 105537 7531 34843859
Cerebrovascular stenosis 11.75 11.17 6 105535 103 34851287
Haematotoxicity 11.75 11.17 5 105536 8189 34843201
Pulmonary alveolar haemorrhage 11.74 11.17 4 105537 7508 34843882
Hepatic function abnormal 11.72 11.17 82 105459 44281 34807109
Kidney transplant rejection 11.70 11.17 4 105537 7493 34843897
Necrotising enterocolitis neonatal 11.67 11.17 8 105533 241 34851149
Thirst decreased 11.66 11.17 4 105537 23 34851367
Cerebral ataxia 11.66 11.17 4 105537 23 34851367
Blood glucose increased 11.64 11.17 137 105404 66581 34784809
Enteritis 11.62 11.17 5 105536 8137 34843253
Gait disturbance 11.62 11.17 338 105203 84802 34766588
Irregular breathing 11.58 11.17 7 105534 169 34851221
Cyanosis 11.55 11.17 72 105469 12692 34838698
Myoclonus 11.46 11.17 80 105461 14645 34836745
Mesenteric vascular occlusion 11.46 11.17 5 105536 59 34851331
Feeling hot 11.41 11.17 26 105515 19346 34832044
Faeces discoloured 11.41 11.17 17 105524 14861 34836529
Death 11.40 11.17 1370 104171 396679 34454711
Jaundice neonatal 11.39 11.17 17 105524 1329 34850061
Enterococcal infection 11.37 11.17 7 105534 9299 34842091
Enterocolitis 11.34 11.17 5 105536 8021 34843369
Blood glucose decreased 11.28 11.17 14 105527 13223 34838167
Cardiac disorder 11.25 11.17 80 105461 43046 34808344
Hypoglycaemia 11.23 11.17 108 105433 54532 34796858
False positive investigation result 11.23 11.17 10 105531 445 34850945

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug abuse 6886.40 9.98 4668 208591 158023 79373106
Toxicity to various agents 5993.24 9.98 6449 206810 415091 79116038
Completed suicide 2404.77 9.98 3116 210143 242651 79288478
Intentional overdose 1959.27 9.98 1876 211383 104084 79427045
Coma 1921.84 9.98 1814 211445 98835 79432294
Overdose 1679.77 9.98 2258 211001 181948 79349181
Respiratory arrest 1394.28 9.98 1187 212072 56363 79474766
Suicide attempt 1382.46 9.98 1388 211871 81544 79449585
Poisoning 1360.97 9.98 846 212413 24426 79506703
Drug dependence 1335.93 9.98 1004 212255 39765 79491364
Somnolence 1144.53 9.98 2184 211075 236797 79294332
Intentional product misuse 953.53 9.98 1223 212036 93942 79437187
Poisoning deliberate 940.28 9.98 601 212658 18227 79512902
Miosis 843.51 9.98 526 212733 15263 79515866
Cardiac arrest 742.14 9.98 1506 211753 170590 79360539
Respiratory depression 737.45 9.98 603 212656 27027 79504102
Sopor 722.78 9.98 643 212616 32367 79498762
Cardio-respiratory arrest 704.85 9.98 1135 212124 107375 79423754
Drug withdrawal syndrome 694.89 9.98 643 212616 34075 79497054
Depressed level of consciousness 684.60 9.98 1052 212207 95600 79435529
Agitation 661.31 9.98 1053 212206 98662 79432467
Intentional self-injury 648.02 9.98 600 212659 31819 79499310
Substance abuse 608.96 9.98 369 212890 10157 79520972
Aggression 558.08 9.98 685 212574 50273 79480856
Suicidal ideation 544.82 9.98 834 212425 75506 79455623
Accidental overdose 480.91 9.98 561 212698 39020 79492109
Neuroleptic malignant syndrome 461.92 9.98 463 212796 27096 79504033
Drug interaction 459.66 9.98 2260 210999 412923 79118206
Bradypnoea 453.40 9.98 251 213008 5801 79525328
Psychotic disorder 375.49 9.98 507 212752 40895 79490234
Joint swelling 367.37 9.98 156 213103 288490 79242639
Withdrawal syndrome 360.74 9.98 401 212858 26453 79504676
Infusion related reaction 355.23 9.98 89 213170 230148 79300981
Asphyxia 349.39 9.98 273 212986 11447 79519682
Synovitis 349.29 9.98 12 213247 150722 79380407
Serotonin syndrome 335.44 9.98 502 212757 44525 79486604
Schizophrenia 330.45 9.98 297 212962 15143 79515986
Rheumatoid arthritis 328.62 9.98 77 213182 208393 79322736
Diarrhoea 325.01 9.98 1236 212023 879253 78651876
Febrile neutropenia 322.02 9.98 108 213151 230891 79300238
Drug intolerance 321.55 9.98 152 213107 263967 79267162
Pneumonia aspiration 317.13 9.98 610 212649 66357 79464772
Mydriasis 307.83 9.98 303 212956 17340 79513789
Altered state of consciousness 301.67 9.98 471 212788 43351 79487778
Rash 280.09 9.98 717 212542 577641 78953488
Arthralgia 279.90 9.98 705 212554 571098 78960031
Bradyphrenia 279.20 9.98 230 213029 10410 79520719
Sedation 259.67 9.98 484 212775 51411 79479718
Arthropathy 253.52 9.98 79 213180 177032 79354097
Seizure 250.58 9.98 1085 212174 187749 79343380
Drug abuser 247.03 9.98 170 213089 5843 79525286
Restlessness 245.72 9.98 444 212815 46048 79485081
Pemphigus 245.68 9.98 4 213255 99578 79431551
Disturbance in attention 242.03 9.98 464 212795 50337 79480792
Anaemia 234.84 9.98 527 212732 444488 79086641
Off label use 234.64 9.98 1445 211814 905770 78625359
Peripheral swelling 233.41 9.98 226 213033 269391 79261738
Hand deformity 231.55 9.98 11 213248 103908 79427221
Congenital nystagmus 231.43 9.98 53 213206 40 79531089
Nasopharyngitis 227.79 9.98 206 213053 253675 79277454
Contraindicated product administered 225.95 9.98 70 213189 157468 79373661
Hypothermia 217.65 9.98 286 212973 22460 79508669
Coma scale abnormal 216.10 9.98 182 213077 8496 79522633
Pericarditis 214.37 9.98 17 213242 104219 79426910
Systemic lupus erythematosus 213.54 9.98 34 213225 121115 79410014
Dysarthria 213.52 9.98 523 212736 67099 79464030
Tachycardia 209.30 9.98 986 212273 176782 79354347
Treatment failure 209.11 9.98 97 213162 170389 79360740
Accidental death 197.06 9.98 130 213129 4161 79526968
Fatigue 194.24 9.98 1575 211684 928152 78602977
Therapeutic product effect decreased 192.22 9.98 99 213160 163764 79367365
Visceral congestion 191.18 9.98 78 213181 878 79530251
Anxiety 187.61 9.98 1222 212037 247290 79283839
Tremor 186.96 9.98 925 212334 169158 79361971
Glossodynia 182.12 9.98 29 213230 103308 79427821
Loss of consciousness 180.80 9.98 908 212351 167035 79364094
Dyspnoea 180.68 9.98 1448 211811 855577 78675552
Abdominal discomfort 177.27 9.98 247 213012 250480 79280649
Panic attack 174.66 9.98 266 212993 23950 79507179
Salivary hypersecretion 173.37 9.98 202 213057 14022 79517107
Cough 171.69 9.98 462 212797 366327 79164802
Alopecia 170.57 9.98 221 213038 231134 79299995
Disorientation 168.73 9.98 457 212802 62319 79468810
Abnormal behaviour 167.78 9.98 328 212931 36093 79495036
Drug withdrawal convulsions 166.09 9.98 92 213167 2128 79529001
General physical health deterioration 164.57 9.98 303 212956 274935 79256194
Exposure via ingestion 163.99 9.98 125 213134 5049 79526080
Death 163.84 9.98 2269 210990 564245 78966884
Status epilepticus 163.83 9.98 263 212996 24778 79506351
Swelling 161.83 9.98 205 213054 216506 79314623
Extrapyramidal disorder 160.59 9.98 247 213012 22432 79508697
Muscle rigidity 160.10 9.98 230 213029 19652 79511477
Stomatitis 158.70 9.98 98 213161 146659 79384470
Hypersensitivity 157.39 9.98 288 212971 261951 79269178
Drug ineffective 155.13 9.98 2002 211257 1078911 78452218
Infection 154.57 9.98 255 213004 241457 79289672
Thrombocytopenia 153.32 9.98 298 212961 264961 79266168
Disease progression 153.23 9.98 160 213099 184202 79346927
Helicobacter infection 150.21 9.98 9 213250 69695 79461434
Housebound 149.65 9.98 54 213205 422 79530707
Dystonia 148.63 9.98 231 213028 21168 79509961
Sinusitis 146.94 9.98 184 213075 195317 79335812
COVID-19 146.11 9.98 124 213135 157550 79373579
Hypomania 143.72 9.98 136 213123 7408 79523721
Drug use disorder 142.47 9.98 144 213115 8507 79522622
Malignant neoplasm progression 137.33 9.98 98 213161 135892 79395237
Nystagmus 136.62 9.98 150 213109 9754 79521375
Wound 136.51 9.98 70 213189 116109 79415020
Interstitial lung disease 135.08 9.98 66 213193 112534 79418595
Logorrhoea 132.97 9.98 103 213156 4262 79526867
Psychomotor hyperactivity 132.87 9.98 193 213066 16656 79514473
Delirium 132.50 9.98 512 212747 84115 79447014
Discomfort 130.20 9.98 88 213171 125529 79405600
Nightmare 126.60 9.98 239 213020 25622 79505507
Depression 126.41 9.98 1002 212257 215788 79315341
Irritability 125.40 9.98 314 212945 40830 79490299
Dissociation 124.93 9.98 96 213163 3925 79527204
Mood swings 124.89 9.98 205 213054 19675 79511454
Rhabdomyolysis 123.46 9.98 575 212684 102556 79428573
Pulmonary congestion 122.33 9.98 242 213017 26858 79504271
Duodenal ulcer perforation 120.29 9.98 17 213242 66194 79464935
Folliculitis 119.79 9.98 7 213252 55373 79475756
Delusion 118.18 9.98 203 213056 20220 79510909
Alcohol poisoning 117.76 9.98 100 213159 4721 79526408
Pain 116.62 9.98 1262 211997 702540 78828589
Confusional state 115.75 9.98 1330 211929 316667 79214462
Pruritus 115.35 9.98 603 212656 394045 79137084
Akathisia 115.08 9.98 159 213100 13100 79518029
Aspiration 112.25 9.98 197 213062 19961 79511168
Developmental delay 111.70 9.98 58 213201 1173 79529956
C-reactive protein abnormal 111.48 9.98 4 213255 48363 79482766
Pyrexia 111.23 9.98 1220 212039 677489 78853640
Drug screen positive 109.25 9.98 106 213153 5957 79525172
Acute kidney injury 108.90 9.98 878 212381 518526 79012603
Emotional disorder 107.97 9.98 161 213098 14226 79516903
Dyskinesia 107.59 9.98 313 212946 44460 79486669
Arthritis 106.83 9.98 90 213169 114790 79416339
Mucosal inflammation 105.81 9.98 35 213224 75545 79455584
Impaired healing 105.71 9.98 51 213208 87604 79443525
Respiratory acidosis 104.33 9.98 139 213120 11061 79520068
Urinary retention 104.13 9.98 361 212898 56269 79474860
Therapeutic product effect incomplete 102.60 9.98 137 213122 141508 79389621
Pancytopenia 102.11 9.98 179 213080 165566 79365563
Strabismus congenital 101.67 9.98 24 213235 24 79531105
Unresponsive to stimuli 101.17 9.98 354 212905 55434 79475695
Electrocardiogram QT prolonged 100.96 9.98 494 212765 89892 79441237
Dyspnoea exertional 100.02 9.98 54 213205 87019 79444110
Brain oedema 99.19 9.98 213 213046 25050 79506079
Myoglobin urine present 98.71 9.98 49 213210 898 79530231
Drug detoxification 98.46 9.98 38 213221 365 79530764
Sepsis 98.31 9.98 379 212880 269049 79262080
Atrial fibrillation 97.27 9.98 243 213016 197643 79333486
Neutropenia 96.66 9.98 418 212841 287292 79243837
Anger 95.93 9.98 168 213091 16994 79514135
Sleep disorder due to general medical condition, insomnia type 95.77 9.98 5 213254 43551 79487578
Generalised tonic-clonic seizure 95.17 9.98 296 212963 43614 79487515
Agoraphobia 94.95 9.98 41 213218 537 79530592
Haemoglobin decreased 94.86 9.98 292 212967 221827 79309302
Mania 94.70 9.98 173 213086 18087 79513042
Hallucination 94.60 9.98 467 212792 85278 79445851
Hallucinations, mixed 94.32 9.98 104 213155 6795 79524334
Derealisation 93.29 9.98 57 213202 1592 79529537
Abdominal pain 92.82 9.98 635 212624 388934 79142195
Hyperhidrosis 92.58 9.98 708 212551 150784 79380345
Jaundice cholestatic 91.53 9.98 131 213128 11153 79519976
Sinus tachycardia 90.59 9.98 260 212999 36648 79494481
Speech disorder 89.83 9.98 335 212924 54110 79477019
Nausea 89.74 9.98 1916 211343 955280 78575849
Bradykinesia 89.42 9.98 109 213150 7934 79523195
Blood creatine phosphokinase increased 88.49 9.98 381 212878 65709 79465420
Parkinsonism 88.39 9.98 159 213100 16425 79514704
Platelet count decreased 88.12 9.98 249 213010 194415 79336714
Self-injurious ideation 87.92 9.98 75 213184 3563 79527566
Depersonalisation/derealisation disorder 86.94 9.98 57 213202 1805 79529324
Gastric pH decreased 86.92 9.98 44 213215 842 79530287
Inflammation 86.50 9.98 74 213185 93679 79437450
Arteriosclerosis coronary artery 86.40 9.98 164 213095 17652 79513477
Cardiac failure congestive 84.83 9.98 157 213102 142245 79388884
Suicidal behaviour 84.79 9.98 70 213189 3177 79527952
Muscle injury 84.71 9.98 14 213245 48547 79482582
Hypotonia 83.95 9.98 135 213124 12735 79518394
Vital capacity decreased 83.35 9.98 55 213204 1761 79529368
Feeling of despair 82.54 9.98 65 213194 2756 79528373
Urticaria 82.28 9.98 239 213020 184962 79346167
Hypoventilation 82.10 9.98 99 213160 7125 79524004
Hallucination, auditory 81.85 9.98 175 213084 20518 79510611
Gastrointestinal disorder 81.77 9.98 125 213134 122080 79409049
Intentional product use issue 80.97 9.98 179 213080 151933 79379196
Alcohol abuse 80.61 9.98 85 213174 5278 79525851
Product dose omission issue 80.49 9.98 364 212895 247173 79283956
Ataxia 79.37 9.98 194 213065 24845 79506284
Gastrointestinal haemorrhage 79.31 9.98 173 213086 147546 79383583
Pulmonary oedema 79.13 9.98 454 212805 87800 79443329
Reversible airways obstruction 78.89 9.98 57 213202 2119 79529010
Prescription drug used without a prescription 78.50 9.98 74 213185 4011 79527118
Injection site pain 78.35 9.98 142 213117 129696 79401433
Cytomegalovirus infection 77.34 9.98 11 213248 42633 79488496
Pain in extremity 76.40 9.98 616 212643 363922 79167207
Catatonia 75.99 9.98 105 213154 8651 79522478
Accidental poisoning 75.60 9.98 50 213209 1607 79529522
Cogwheel rigidity 75.32 9.98 64 213195 3024 79528105
Sudden death 75.20 9.98 178 213081 22333 79508796
Blood pressure fluctuation 75.15 9.98 43 213216 67102 79464027
Erythema 74.61 9.98 325 212934 222965 79308164
Psychotic symptom 74.33 9.98 60 213199 2637 79528492
Hypertonia 73.98 9.98 94 213165 7138 79523991
Drooling 73.53 9.98 85 213174 5849 79525280
Dependence 73.45 9.98 57 213202 2365 79528764
Blood pressure systolic increased 73.41 9.98 44 213215 66942 79464187
Snoring 72.82 9.98 82 213177 5484 79525645
Product use issue 72.81 9.98 301 212958 209521 79321608
Drug hypersensitivity 71.77 9.98 486 212773 298430 79232699
Pleural effusion 71.66 9.98 178 213081 145084 79386045
Depressed mood 71.57 9.98 288 212971 48192 79482937
Psoriatic arthropathy 71.42 9.98 62 213197 77937 79453192
Alcohol interaction 71.04 9.98 76 213183 4798 79526331
Hypotension 70.97 9.98 1608 211651 438709 79092420
Loss of personal independence in daily activities 70.50 9.98 103 213156 102477 79428652
Psychomotor skills impaired 69.96 9.98 78 213181 5159 79525970
Paranoia 68.58 9.98 157 213102 19275 79511854
Hepatic enzyme increased 68.44 9.98 254 213005 182356 79348773
Lower respiratory tract infection 68 9.98 153 213106 129067 79402062
Asthma 67.85 9.98 164 213095 134931 79396198
Herpes zoster 67.43 9.98 90 213169 92993 79438136
Stiff person syndrome 66.89 9.98 27 213232 295 79530834
Hypoxic-ischaemic encephalopathy 66.70 9.98 93 213166 7727 79523402
Toxic encephalopathy 66.57 9.98 114 213145 11326 79519803
Inappropriate schedule of product administration 66.49 9.98 163 213096 133465 79397664
Pulmonary fibrosis 66.15 9.98 18 213241 44094 79487035
Haematochezia 65.28 9.98 83 213176 87562 79443567
Thinking abnormal 64.87 9.98 122 213137 13039 79518090
Antipsychotic drug level increased 63.44 9.98 79 213180 5878 79525251
Pneumonia 63.04 9.98 1317 211942 658929 78872200
Fibromyalgia 62.82 9.98 48 213211 64292 79466837
Irritable bowel syndrome 62.62 9.98 45 213214 62196 79468933
Mental disorder 62.35 9.98 205 213054 31097 79500032
Toxicologic test abnormal 61.96 9.98 41 213218 1319 79529810
Behaviour disorder 61.35 9.98 80 213179 6233 79524896
Ascites 61.15 9.98 67 213192 75495 79455634
Tearfulness 60.93 9.98 78 213181 5967 79525162
Mental impairment 60.88 9.98 148 213111 18888 79512241
Feeling of body temperature change 60.55 9.98 73 213186 5253 79525876
Blood pressure increased 60.51 9.98 325 212934 211035 79320094
Fluid retention 58.62 9.98 60 213199 69749 79461380
Optic nerve hypoplasia 57.84 9.98 13 213246 8 79531121
Weight decreased 57.40 9.98 640 212619 354558 79176571
Product use in unapproved indication 57.15 9.98 413 212846 249946 79281183
Sputum culture positive 56.96 9.98 60 213199 3721 79527408
Bone marrow failure 56.80 9.98 33 213226 51074 79480055
Epilepsy 56.58 9.98 238 213021 40622 79490507
Neoplasm progression 56.56 9.98 34 213225 51648 79479481
Electroencephalogram abnormal 56.17 9.98 71 213188 5363 79525766
Victim of chemical submission 55.78 9.98 28 213231 526 79530603
Knee arthroplasty 55.53 9.98 23 213236 43225 79487904
Asthenia 54.14 9.98 1003 212256 510686 79020443
Colitis 53.99 9.98 70 213189 73237 79457892
Productive cough 53.83 9.98 96 213163 88235 79442894
Pneumocystis jirovecii pneumonia 53.21 9.98 11 213248 32497 79498632
H1N1 influenza 53.00 9.98 48 213211 2471 79528658
Tension 52.76 9.98 62 213197 4342 79526787
Ill-defined disorder 52.66 9.98 59 213200 65816 79465313
Nasal congestion 51.49 9.98 78 213181 76474 79454655
Self-medication 51.38 9.98 66 213193 5066 79526063
Abdominal pain upper 51.19 9.98 369 212890 223450 79307679
Cyanosis 51.13 9.98 166 213093 25016 79506113
Hip arthroplasty 51.03 9.98 16 213243 35740 79495389
Strabismus 51.01 9.98 47 213212 2474 79528655
Prostate cancer 49.09 9.98 14 213245 33254 79497875
Persecutory delusion 48.94 9.98 63 213196 4846 79526283
Congenital visual acuity reduced 48.20 9.98 11 213248 8 79531121
Bronchial secretion retention 47.88 9.98 57 213202 4047 79527082
Stupor 47.46 9.98 74 213185 6798 79524331
Memory impairment 47.35 9.98 482 212777 111252 79419877
Drowning 47.27 9.98 29 213230 816 79530313
Hypervolaemia 46.83 9.98 28 213231 42662 79488467
Wheezing 46.55 9.98 158 213101 116506 79414623
Oropharyngeal pain 46.48 9.98 144 213115 109209 79421920
Brain injury 46.24 9.98 98 213161 11419 79519710
Basal cell carcinoma 46.20 9.98 21 213238 37354 79493775
Drug diversion 45.90 9.98 33 213226 1217 79529912
Acute myeloid leukaemia 45.57 9.98 13 213246 30872 79500257
Autonomic nervous system imbalance 45.50 9.98 59 213200 4571 79526558
Epistaxis 45.19 9.98 150 213109 111365 79419764
Drug level increased 45.18 9.98 218 213041 39433 79491696
Skin ulcer 44.95 9.98 47 213212 54103 79477026
Myelosuppression 44.81 9.98 26 213233 40270 79490859
Insomnia 44.78 9.98 912 212347 244258 79286871
Physical assault 44.74 9.98 36 213223 1575 79529554
Oedema peripheral 44.61 9.98 445 212814 251843 79279286
Decreased appetite 44.50 9.98 646 212613 341772 79189357
Antipsychotic drug level decreased 44.23 9.98 32 213227 1192 79529937
Psychotic behaviour 44.22 9.98 31 213228 1098 79530031
Respiratory rate decreased 44.19 9.98 62 213197 5181 79525948
Injection site erythema 44.12 9.98 89 213170 78108 79453021
Incontinence 44.10 9.98 109 213150 14055 79517074
Abnormal dreams 43.40 9.98 95 213164 11317 79519812
Postmortem blood drug level abnormal 43.25 9.98 25 213234 629 79530500
Therapeutic response decreased 43.17 9.98 70 213189 66783 79464346
Oedema 43.06 9.98 169 213090 119411 79411718
Pneumonitis 42.91 9.98 60 213199 60800 79470329
COVID-19 pneumonia 42.83 9.98 12 213247 28837 79502292
Red blood cell sedimentation rate increased 42.69 9.98 36 213223 45906 79485223
Psoriasis 42.46 9.98 112 213147 89475 79441654
Victim of sexual abuse 42.43 9.98 23 213236 509 79530620
Blood pressure diastolic decreased 42.28 9.98 14 213245 30202 79500927
Renal impairment 42.22 9.98 248 213011 157535 79373594
Colitis ulcerative 42.20 9.98 20 213239 34722 79496407
Rash pruritic 41.73 9.98 80 213179 71549 79459580
Cardiac failure 41.64 9.98 243 213016 154599 79376530
Victim of crime 41.45 9.98 22 213237 466 79530663
Blood creatinine increased 41.34 9.98 244 213015 154813 79376316
Hyperthermia 41.33 9.98 124 213135 17913 79513216
International normalised ratio increased 40.85 9.98 105 213154 84616 79446513
Myelodysplastic syndrome 40.74 9.98 15 213244 30286 79500843
Generalised anxiety disorder 40.70 9.98 39 213220 2158 79528971
Neuropathy peripheral 40.58 9.98 217 213042 141088 79390041
Psychomotor retardation 40.51 9.98 65 213194 6119 79525010
Potentiating drug interaction 40.09 9.98 79 213180 8740 79522389
Spleen congestion 40.08 9.98 21 213238 433 79530696
Condition aggravated 39.52 9.98 1029 212230 500095 79031034
Immobilisation prolonged 39.30 9.98 14 213245 105 79531024
Therapeutic product ineffective 39.22 9.98 36 213223 1886 79529243
Total lung capacity increased 39.21 9.98 39 213220 2259 79528870
Electrocardiogram J wave 39.17 9.98 12 213247 52 79531077
Psychogenic seizure 39.07 9.98 36 213223 1895 79529234
Multiple sclerosis relapse 38.87 9.98 235 213024 46298 79484831
Osteonecrosis of jaw 38.80 9.98 35 213224 43191 79487938
PCO2 increased 38.59 9.98 35 213224 1805 79529324
Mutism 38.18 9.98 39 213220 2333 79528796
Bladder dilatation 38.09 9.98 37 213222 2082 79529047
Clostridium difficile infection 37.79 9.98 35 213224 42650 79488479
Mobility decreased 37.70 9.98 183 213076 121992 79409137
Bezoar 37.58 9.98 41 213218 2647 79528482
Cytopenia 37.57 9.98 5 213254 20378 79510751
Hyperprolactinaemia 37.50 9.98 54 213205 4622 79526507
Alcoholism 37.46 9.98 48 213211 3675 79527454
White blood cell count decreased 37.20 9.98 323 212936 187965 79343164
Menstrual disorder 37.15 9.98 50 213209 4017 79527112
Necrotising colitis 37.15 9.98 27 213232 1013 79530116
Vision blurred 37.13 9.98 440 212819 105458 79425671
Urinary incontinence 37.02 9.98 211 213048 40698 79490431
Bronchitis 36.76 9.98 202 213057 130442 79400687
Influenza 36.68 9.98 200 213059 129406 79401723
Myoclonus 36.66 9.98 159 213100 27501 79503628
Electrocardiogram QRS complex prolonged 36.55 9.98 86 213173 10747 79520382
Pancreatic fibrosis 36.32 9.98 13 213246 99 79531030
Social avoidant behaviour 36.30 9.98 54 213205 4760 79526369
Incoherent 36.30 9.98 70 213189 7622 79523507
Homicide 36.16 9.98 28 213231 1158 79529971
Dehydration 35.91 9.98 458 212801 247729 79283400
Chest discomfort 35.86 9.98 219 213040 137825 79393304
Blood pH decreased 35.75 9.98 53 213206 4658 79526471
Blister 35.70 9.98 181 213078 119295 79411834
Rectal haemorrhage 35.69 9.98 96 213163 76204 79454925
Drug withdrawal syndrome neonatal 35.55 9.98 17 213242 286 79530843
Hyperkalaemia 35.50 9.98 171 213088 114227 79416902
C-reactive protein increased 35.48 9.98 201 213058 128826 79402303
Rhinorrhoea 35.37 9.98 96 213163 75978 79455151
Transfusion 35.36 9.98 7 213252 21323 79509806
Transplant rejection 35.28 9.98 5 213254 19432 79511697
Inadequate analgesia 35.01 9.98 52 213207 4577 79526552
Cytokine release syndrome 34.96 9.98 27 213232 35971 79495158
Injection site pruritus 34.76 9.98 37 213222 42246 79488883
Autonomic dysreflexia 34.71 9.98 19 213240 429 79530700
Muscle disorder 34.70 9.98 58 213201 5649 79525480
Echolalia 34.67 9.98 18 213241 364 79530765
Haemophagocytic lymphohistiocytosis 34.50 9.98 8 213251 21829 79509300
Device expulsion 34.44 9.98 13 213246 25848 79505281
Weight increased 34.40 9.98 528 212731 276858 79254271
Frequent bowel movements 34.38 9.98 18 213241 29521 79501608
Apnoea 34.28 9.98 88 213171 11616 79519513
Hospitalisation 34.04 9.98 133 213126 94103 79437026
Euphoric mood 33.67 9.98 68 213191 7658 79523471
Adverse event 33.57 9.98 69 213190 60145 79470984
Vestibular disorder 33.55 9.98 37 213222 2418 79528711
Balance disorder 33.46 9.98 408 212851 98449 79432680
Penis injury 33.40 9.98 13 213246 128 79531001
Sinus bradycardia 33.36 9.98 145 213114 25102 79506027
Palmar-plantar erythrodysaesthesia syndrome 33.27 9.98 24 213235 33110 79498019
Microcephaly 33.22 9.98 14 213245 172 79530957
Acute psychosis 33.13 9.98 48 213211 4132 79526997
Cataract 33.12 9.98 73 213186 62047 79469082
Encephalitis toxic 33.05 9.98 16 213243 277 79530852
Osteoarthritis 32.98 9.98 121 213138 87188 79443941
Injection site reaction 32.96 9.98 60 213199 54725 79476404
Melaena 32.92 9.98 71 213188 60819 79470310
Hypercapnic coma 32.90 9.98 18 213241 406 79530723
Injection site swelling 32.69 9.98 47 213212 47085 79484044
Bacteraemia 32.67 9.98 24 213235 32800 79498329
Chronic kidney disease 32.66 9.98 81 213178 66073 79465056
Renal ischaemia 32.34 9.98 26 213233 1136 79529993
Plasma cell myeloma 32.34 9.98 58 213201 53201 79477928
Treatment noncompliance 32.30 9.98 245 213014 52023 79479106
Joint stiffness 32.16 9.98 37 213222 40793 79490336
Schizoaffective disorder 32.15 9.98 34 213225 2118 79529011
Renal failure 32.07 9.98 363 212896 200605 79330524
Hypokinesia 32.03 9.98 118 213141 18942 79512187
Tumour lysis syndrome 31.94 9.98 12 213247 23927 79507202
Metastases to liver 31.87 9.98 18 213241 28296 79502833
Chills 31.59 9.98 275 212984 159959 79371170
Coordination abnormal 31.50 9.98 110 213149 17202 79513927
Patient uncooperative 31.26 9.98 21 213238 693 79530436
Opiates positive 31.26 9.98 24 213235 980 79530149
Cortisol increased 31.25 9.98 19 213240 526 79530603
Hyperacusis 31.24 9.98 34 213225 2189 79528940
Cryopyrin associated periodic syndrome 31.13 9.98 17 213242 382 79530747
Liver disorder 31.02 9.98 95 213164 72322 79458807
Multiple sclerosis 31.01 9.98 130 213129 22152 79508977
PO2 increased 30.96 9.98 29 213230 1559 79529570
Alcohol use 30.59 9.98 50 213209 4781 79526348
Hepatic steatosis 30.52 9.98 189 213070 37549 79493580
Diabetes insipidus 30.22 9.98 52 213207 5185 79525944
Asthma-chronic obstructive pulmonary disease overlap syndrome 30.04 9.98 40 213219 3181 79527948
Neutrophil count decreased 30.01 9.98 139 213120 93820 79437309
Nodule 29.89 9.98 12 213247 22982 79508147
Maternal exposure during pregnancy 29.81 9.98 228 213031 136310 79394819
Tubulointerstitial nephritis 29.74 9.98 35 213224 38200 79492929
Parosmia 29.70 9.98 61 213198 6953 79524176
Neurosis 29.68 9.98 17 213242 420 79530709
Pyramidal tract syndrome 29.65 9.98 19 213240 578 79530551
Amylase increased 29.50 9.98 81 213178 11128 79520001
Adrenal insufficiency 29.44 9.98 20 213239 28467 79502662
Persistent depressive disorder 29.44 9.98 25 213234 1180 79529949
Cardiomegaly 29.39 9.98 144 213115 26208 79504921
Headache 29.37 9.98 1439 211820 652333 78878796
Restless legs syndrome 29.36 9.98 119 213140 19973 79511156
Blood potassium increased 29.17 9.98 155 213104 29120 79502009
Musculoskeletal stiffness 29.15 9.98 313 212946 174695 79356434
Myocardial fibrosis 29.03 9.98 29 213230 1689 79529440
Musculoskeletal pain 28.93 9.98 158 213101 102196 79428933
Postmortem blood drug level increased 28.89 9.98 21 213238 788 79530341
Cellulitis 28.86 9.98 172 213087 108888 79422241
Acidosis 28.84 9.98 117 213142 19645 79511484
Sputum discoloured 28.84 9.98 11 213248 21732 79509397
Bursitis 28.76 9.98 32 213227 35812 79495317
Paralysis 28.70 9.98 89 213170 13088 79518041
Ulcer 28.45 9.98 23 213236 29949 79501180
Hallucination, visual 28.43 9.98 167 213092 32562 79498567
Substance use disorder 28.28 9.98 22 213237 916 79530213
Hepatocellular injury 28.25 9.98 221 213038 47372 79483757
Hanging 28.22 9.98 12 213247 151 79530978
Liver injury 28.20 9.98 69 213190 56545 79474584
Pulmonary arterial hypertension 27.89 9.98 21 213238 28345 79502784
Adverse drug reaction 27.80 9.98 88 213171 66304 79464825
Pupillary disorder 27.79 9.98 18 213241 558 79530571
Cholelithiasis 27.73 9.98 238 213021 52426 79478703
Angioedema 27.66 9.98 107 213152 75928 79455201
Panic disorder 27.66 9.98 37 213222 2955 79528174
Hyperglycaemia 27.55 9.98 96 213163 70239 79460890
Localised infection 27.54 9.98 36 213223 37539 79493590
Joint range of motion decreased 27.49 9.98 29 213230 33253 79497876
Live birth 27.45 9.98 8 213251 18736 79512393
Poor quality sleep 27.40 9.98 127 213132 22595 79508534
Therapy interrupted 27.39 9.98 26 213233 31315 79499814
Fear 27.34 9.98 124 213135 21862 79509267
Portal tract inflammation 27.27 9.98 11 213248 120 79531009
Anterograde amnesia 27.13 9.98 19 213240 672 79530457
Drug withdrawal maintenance therapy 27.11 9.98 9 213250 53 79531076
Circulatory collapse 27.00 9.98 183 213076 37485 79493644
Somnambulism 26.92 9.98 52 213207 5669 79525460
Illusion 26.89 9.98 28 213231 1713 79529416
Lethargy 26.85 9.98 334 212925 80958 79450171
Myocarditis 26.59 9.98 122 213137 21611 79509518
Somatic delusion 26.47 9.98 19 213240 699 79530430
Tardive dyskinesia 26.45 9.98 75 213184 10496 79520633
Fatty liver alcoholic 26.43 9.98 9 213250 58 79531071
Feeling jittery 26.38 9.98 85 213174 12756 79518373
Cardiopulmonary failure 26.30 9.98 57 213202 6744 79524385
Nervousness 26.18 9.98 166 213093 33249 79497880
Feeling drunk 26.12 9.98 46 213213 4673 79526456
Sexual abuse 26.05 9.98 13 213246 241 79530888
Bradycardia 25.97 9.98 508 212751 135049 79396080
Blood alcohol increased 25.93 9.98 24 213235 1271 79529858
Haematotoxicity 25.92 9.98 5 213254 15514 79515615
Apathy 25.85 9.98 85 213174 12892 79518237
Amnesia 25.75 9.98 270 212989 62787 79468342
Back pain 25.72 9.98 618 212641 303562 79227567
Leukopenia 25.70 9.98 194 213065 116319 79414810
Impaired reasoning 25.56 9.98 10 213249 100 79531029
Social anxiety disorder 25.50 9.98 17 213242 554 79530575
Body temperature decreased 25.46 9.98 29 213230 32116 79499013
Thrombotic microangiopathy 25.45 9.98 11 213248 20158 79510971
Disinhibition 25.37 9.98 33 213226 2565 79528564
Cerebrovascular accident 25.36 9.98 279 212980 155013 79376116
Thrombosis 25.35 9.98 127 213132 83973 79447156
Bronchopulmonary aspergillosis 25.34 9.98 14 213245 22280 79508849
Pathogen resistance 25.32 9.98 4 213255 14338 79516791
Chemical submission 25.30 9.98 14 213245 323 79530806
Troponin increased 24.99 9.98 110 213149 19145 79511984
Uveitis 24.99 9.98 7 213252 16823 79514306
Aspergillus infection 24.91 9.98 10 213249 19151 79511978
Calcium deficiency 24.78 9.98 20 213239 879 79530250
Major depression 24.74 9.98 66 213193 8914 79522215
Opisthotonus 24.71 9.98 18 213241 678 79530451
Injection site bruising 24.58 9.98 45 213214 40957 79490172
Emotional distress 24.50 9.98 187 213072 39782 79491347
Liver function test increased 24.43 9.98 43 213216 39730 79491399
Type 2 diabetes mellitus 24.42 9.98 75 213184 57047 79474082
Drug tolerance decreased 24.36 9.98 3 213256 12975 79518154
Crying 24.34 9.98 124 213135 22919 79508210
Haematuria 24.32 9.98 98 213161 68738 79462391
Sluggishness 24.19 9.98 54 213205 6518 79524611
Hypertension 24.15 9.98 687 212572 330305 79200824
Bladder cancer 24.09 9.98 11 213248 19515 79511614
Joint effusion 24.08 9.98 9 213250 18005 79513124
Upper respiratory tract infection 24.01 9.98 144 213115 91024 79440105
Fungal infection 23.99 9.98 47 213212 41701 79489428
Tenosynovitis 23.98 9.98 6 213253 15548 79515581
Pain in jaw 23.98 9.98 55 213204 46096 79485033
Flashback 23.85 9.98 13 213246 291 79530838
Rhesus antigen positive 23.65 9.98 10 213249 124 79531005
Clostridium difficile colitis 23.59 9.98 31 213228 32252 79498877
Hostility 23.59 9.98 30 213229 2280 79528849
Aspartate aminotransferase increased 23.48 9.98 247 213012 138394 79392735
Terminal dribbling 23.34 9.98 6 213253 11 79531118
Marchiafava-Bignami disease 23.34 9.98 6 213253 11 79531118
Tuberculosis 23.17 9.98 6 213253 15192 79515937
Peripheral venous disease 22.92 9.98 7 213252 15902 79515227
Emotional poverty 22.91 9.98 19 213240 868 79530261
Acute myocardial infarction 22.84 9.98 117 213142 76919 79454210
Septic shock 22.79 9.98 214 213045 122587 79408542
Neoplasm malignant 22.78 9.98 31 213228 31779 79499350
Swollen tongue 22.74 9.98 193 213066 42377 79488752
Skin necrosis 22.61 9.98 10 213249 18077 79513052
Malaise 22.60 9.98 1075 212184 488794 79042335
Oral discharge 22.53 9.98 12 213247 256 79530873
Patient restraint 22.49 9.98 9 213250 96 79531033
Gait deviation 22.45 9.98 8 213251 60 79531069
Suicide threat 22.34 9.98 8 213251 61 79531068
Injection site warmth 22.28 9.98 6 213253 14801 79516328
Diverticulitis 22.09 9.98 57 213202 45879 79485250
Blood prolactin increased 22.07 9.98 39 213220 3972 79527157
Judgement impaired 22.07 9.98 22 213237 1278 79529851
Paradoxical drug reaction 22.06 9.98 55 213204 7130 79523999
Conversion disorder 21.96 9.98 26 213233 1835 79529294
Mucosal erosion 21.95 9.98 29 213230 2289 79528840
Aphasia 21.94 9.98 206 213053 46526 79484603
Staring 21.88 9.98 31 213228 2614 79528515
Infective pulmonary exacerbation of cystic fibrosis 21.77 9.98 4 213255 12847 79518282
Upper gastrointestinal haemorrhage 21.75 9.98 49 213210 41331 79489798
Electrocardiogram QRS complex shortened 21.75 9.98 17 213242 713 79530416
Hypocalcaemia 21.74 9.98 65 213194 49859 79481270
Contusion 21.70 9.98 274 212985 148502 79382627
Personality change 21.52 9.98 68 213191 10102 79521027
Needle track marks 21.48 9.98 8 213251 69 79531060
Dry skin 21.47 9.98 101 213158 67894 79463235
Distractibility 21.44 9.98 17 213242 728 79530401
Pain threshold decreased 21.29 9.98 6 213253 18 79531111
Pulmonary contusion 21.18 9.98 9 213250 113 79531016
Anaphylactic reaction 21.15 9.98 134 213125 83609 79447520
Right ventricular failure 21.12 9.98 19 213240 23478 79507651
Cerebral haemorrhage 21.08 9.98 81 213178 57592 79473537
Ileus paralytic 20.98 9.98 65 213194 9555 79521574
Partial seizures 20.83 9.98 62 213197 8916 79522213
Heart rate decreased 20.73 9.98 107 213152 70209 79460920
Faecaloma 20.63 9.98 73 213186 11491 79519638
Clonus 20.62 9.98 52 213207 6788 79524341
Hyperreflexia 20.50 9.98 59 213200 8326 79522803
Grip strength decreased 20.48 9.98 17 213242 21852 79509277
Tissue infiltration 20.39 9.98 16 213243 675 79530454
Theft 20.35 9.98 11 213248 242 79530887
Morbid thoughts 20.34 9.98 17 213242 785 79530344
Sleep disorder 20.28 9.98 332 212927 85345 79445784
Anticonvulsant drug level above therapeutic 20.22 9.98 20 213239 1151 79529978
Trismus 20.21 9.98 45 213214 5422 79525707
Hypersomnia 20.18 9.98 118 213141 22968 79508161
Lupus-like syndrome 20.14 9.98 6 213253 13851 79517278
Febrile bone marrow aplasia 20.12 9.98 5 213254 13015 79518114
Priapism 20.05 9.98 40 213219 4465 79526664
Erectile dysfunction 19.97 9.98 85 213174 14579 79516550
Suspected suicide attempt 19.94 9.98 12 213247 326 79530803
Drug-induced liver injury 19.84 9.98 100 213159 66017 79465112
Affective disorder 19.83 9.98 58 213201 8261 79522868
Oesophageal carcinoma 19.77 9.98 3 213256 11081 79520048
Multiple-drug resistance 19.66 9.98 60 213199 8748 79522381
Urine sodium increased 19.59 9.98 10 213249 195 79530934
Oxygen saturation abnormal 19.58 9.98 40 213219 4542 79526587
Galactorrhoea 19.48 9.98 35 213224 3611 79527518
Delirium tremens 19.46 9.98 16 213243 722 79530407
Sciatica 19.44 9.98 37 213222 33185 79497944
Tendonitis 19.42 9.98 21 213238 23809 79507320
Neutrophil count increased 19.42 9.98 140 213119 29256 79501873
Cardiac arrest neonatal 19.40 9.98 6 213253 27 79531102
Taste disorder 19.39 9.98 9 213250 15814 79515315
Muscle twitching 19.38 9.98 123 213136 24641 79506488
Drug tolerance increased 19.33 9.98 15 213244 622 79530507
Penile haemorrhage 19.32 9.98 14 213245 523 79530606
Negative symptoms in schizophrenia 19.28 9.98 9 213250 143 79530986
Drug eruption 19.27 9.98 57 213202 43878 79487251
Sedation complication 19.20 9.98 88 213171 15581 79515548
Myoclonic epilepsy 19.20 9.98 25 213234 1945 79529184
Basal ganglion degeneration 19.19 9.98 13 213246 435 79530694
Delusion of reference 19.17 9.98 9 213250 145 79530984
Gallbladder cholesterolosis 19.15 9.98 15 213244 631 79530498
Osteoporosis 19.14 9.98 77 213182 54035 79477094
Blood cholesterol increased 19.13 9.98 138 213121 83582 79447547
Substance abuser 19.12 9.98 9 213250 146 79530983
Hyperchloraemia 19.08 9.98 19 213240 1102 79530027
Chest pain 18.83 9.98 593 212666 281711 79249418
Lung disorder 18.79 9.98 132 213127 80425 79450704
Squamous cell carcinoma of skin 18.78 9.98 7 213252 14026 79517103
Foot deformity 18.76 9.98 22 213237 24052 79507077
Sensory disturbance 18.72 9.98 85 213174 14992 79516137
Dyspepsia 18.66 9.98 193 213066 108494 79422635
Pleurothotonus 18.65 9.98 28 213231 2488 79528641
Panniculitis 18.64 9.98 5 213254 12366 79518763
Breathing-related sleep disorder 18.54 9.98 10 213249 219 79530910
Haemoptysis 18.38 9.98 82 213177 55917 79475212
Learning disorder 18.37 9.98 14 213245 565 79530564
Full blood count decreased 18.35 9.98 27 213232 26792 79504337
Benzodiazepine drug level increased 18.26 9.98 10 213249 226 79530903
Blood pressure diastolic increased 18.24 9.98 8 213251 14534 79516595
Sensory loss 18.24 9.98 76 213183 12915 79518214
Homicidal ideation 18.24 9.98 33 213226 3424 79527705
Suspected counterfeit product 18.23 9.98 14 213245 572 79530557
Borderline personality disorder 18.21 9.98 17 213242 910 79530219
Posturing 18.21 9.98 18 213241 1035 79530094
Alpha 1 microglobulin increased 18.16 9.98 7 213252 67 79531062
Refraction disorder 18.16 9.98 7 213252 67 79531062
Oromandibular dystonia 18.14 9.98 18 213241 1040 79530089
Blood osmolarity decreased 18.08 9.98 20 213239 1311 79529818
Hyperammonaemia 18.08 9.98 68 213191 11025 79520104
Autoimmune disorder 18.07 9.98 11 213248 16601 79514528
Poverty of speech 18.06 9.98 14 213245 580 79530549
Seizure cluster 18.03 9.98 12 213247 390 79530739
Myocarditis septic 17.98 9.98 6 213253 36 79531093
Product communication issue 17.98 9.98 18 213241 1051 79530078
Accommodation disorder 17.97 9.98 14 213245 584 79530545
Gastrointestinal motility disorder 17.90 9.98 46 213213 6076 79525053
Decreased interest 17.88 9.98 34 213225 3663 79527466
Pancreatic carcinoma 17.79 9.98 7 213252 13570 79517559
Premature labour 17.66 9.98 56 213203 8334 79522795
Hepatic necrosis 17.59 9.98 59 213200 9041 79522088
Ejaculation delayed 17.56 9.98 9 213250 177 79530952
Slow speech 17.56 9.98 27 213232 2451 79528678
Affect lability 17.51 9.98 68 213191 11191 79519938
Lid lag 17.46 9.98 7 213252 75 79531054
Illogical thinking 17.38 9.98 7 213252 76 79531053
Negativism 17.29 9.98 16 213243 847 79530282
Alcohol withdrawal syndrome 17.28 9.98 24 213235 1987 79529142
Bradycardia foetal 17.20 9.98 8 213251 126 79531003
Diet refusal 17.16 9.98 16 213243 855 79530274
Generalised oedema 17.09 9.98 23 213236 23686 79507443
Skin reaction 16.98 9.98 11 213248 16057 79515072
Carcinoid tumour of the stomach 16.98 9.98 9 213250 190 79530939
Multiple allergies 16.95 9.98 64 213195 10396 79520733
Performance fear 16.95 9.98 4 213255 4 79531125
Pneumonia bacterial 16.94 9.98 16 213243 19315 79511814
Muscle tightness 16.93 9.98 74 213185 12840 79518289
Enthesopathy 16.92 9.98 5 213254 11603 79519526
Base excess 16.91 9.98 7 213252 82 79531047
Accident 16.84 9.98 57 213202 8774 79522355
Obsessive-compulsive disorder 16.78 9.98 44 213215 5883 79525246
Breast cancer stage III 16.77 9.98 3 213256 9823 79521306
Enterochromaffin cell hyperplasia 16.68 9.98 7 213252 85 79531044
Libido disorder 16.67 9.98 10 213249 270 79530859
Facial spasm 16.66 9.98 15 213244 766 79530363
Faecal disimpaction 16.64 9.98 5 213254 20 79531109
Systemic infection 16.59 9.98 3 213256 9749 79521380
Hypomagnesaemia 16.44 9.98 67 213192 46844 79484285
Right ventricular hypertrophy 16.31 9.98 21 213238 1616 79529513
Dyspraxia 16.28 9.98 10 213249 282 79530847
Cyclothymic disorder 16.21 9.98 9 213250 209 79530920
Osteonecrosis 16.20 9.98 37 213222 31058 79500071
Thymus disorder 16.12 9.98 10 213249 287 79530842
Reflexes abnormal 16.08 9.98 16 213243 927 79530202
Urine osmolarity increased 16.06 9.98 10 213249 289 79530840
Oral discomfort 16.05 9.98 60 213199 9700 79521429
Intervertebral disc disorder 15.95 9.98 38 213221 4787 79526342
Poor venous access 15.92 9.98 15 213244 18134 79512995
Osmolar gap abnormal 15.92 9.98 7 213252 96 79531033
Sputum culture 15.91 9.98 9 213250 217 79530912
Analgesic drug level above therapeutic 15.91 9.98 12 213247 477 79530652
Proteinuria 15.88 9.98 40 213219 32462 79498667
Device difficult to use 15.81 9.98 8 213251 13377 79517752
Retrograde amnesia 15.71 9.98 13 213246 592 79530537
Angina pectoris 15.66 9.98 78 213181 51654 79479475
Drug screen false positive 15.65 9.98 17 213242 1092 79530037
Oral pain 15.64 9.98 39 213220 31759 79499370
Choking 15.61 9.98 69 213190 12032 79519097
Myofascial pain syndrome 15.58 9.98 23 213236 2014 79529115
Violence-related symptom 15.52 9.98 14 213245 717 79530412
Clonic convulsion 15.51 9.98 18 213241 1244 79529885
Claustrophobia 15.42 9.98 18 213241 1252 79529877
Enteritis 15.39 9.98 10 213249 14573 79516556
Cardiac death 15.38 9.98 20 213239 1554 79529575
Obsessive thoughts 15.36 9.98 17 213242 1115 79530014
Colon cancer 15.27 9.98 10 213249 14513 79516616
Reaction to excipient 15.23 9.98 20 213239 1569 79529560
Antipsychotic drug level above therapeutic 15.21 9.98 23 213236 2057 79529072
Pupillary reflex impaired 15.20 9.98 30 213229 3323 79527806
Blood bicarbonate decreased 15.17 9.98 39 213220 5152 79525977
Pneumoconiosis 15.13 9.98 9 213250 239 79530890
Electrocardiogram repolarisation abnormality 15.09 9.98 24 213235 2243 79528886
Basilar migraine 15.08 9.98 6 213253 63 79531066
Gait disturbance 15.07 9.98 689 212570 206817 79324312
Substance-induced psychotic disorder 14.97 9.98 30 213229 3359 79527770
Eye irritation 14.97 9.98 20 213239 20661 79510468
Hypotensive crisis 14.90 9.98 7 213252 113 79531016
Ankylosing spondylitis 14.86 9.98 7 213252 12198 79518931
Pulmonary alveolar haemorrhage 14.86 9.98 6 213253 11451 79519678
Polyarthritis 14.86 9.98 7 213252 12195 79518934
Oral herpes 14.85 9.98 32 213227 27422 79503707
Blood sodium decreased 14.82 9.98 145 213114 33110 79498019
Cerebellar syndrome 14.82 9.98 40 213219 5440 79525689
Immunodeficiency 14.81 9.98 22 213237 21746 79509383
Diastolic hypotension 14.80 9.98 8 213251 176 79530953
Tonic posturing 14.78 9.98 3 213256 0 79531129
Guillain-Barre syndrome 14.74 9.98 3 213256 8962 79522167
Illness anxiety disorder 14.71 9.98 9 213250 252 79530877
Dysgeusia 14.69 9.98 91 213168 57086 79474043
Wrong rate 14.67 9.98 6 213253 68 79531061
Allodynia 14.66 9.98 20 213239 1628 79529501
Toxic epidermal necrolysis 14.65 9.98 183 213076 44398 79486731
Oropharyngeal oedema 14.63 9.98 11 213248 435 79530694
Coeliac disease 14.63 9.98 6 213253 11345 79519784
Hyperbilirubinaemia 14.62 9.98 27 213232 24491 79506638
Therapy non-responder 14.60 9.98 167 213092 92138 79438991
Upper-airway cough syndrome 14.57 9.98 66 213193 11627 79519502
Libido decreased 14.55 9.98 39 213220 5282 79525847
Rash maculo-papular 14.54 9.98 89 213170 55989 79475140
Lower gastrointestinal haemorrhage 14.54 9.98 13 213246 16112 79515017
Metastases to bone 14.47 9.98 27 213232 24400 79506729
Cardiotoxicity 14.46 9.98 68 213191 12171 79518958
Diabetic ketoacidosis 14.44 9.98 45 213214 34077 79497052
Medication error 14.44 9.98 261 212998 68381 79462748
Impulsive behaviour 14.44 9.98 27 213232 2873 79528256
Inappropriate antidiuretic hormone secretion 14.42 9.98 120 213139 26193 79504936
Blood osmolarity increased 14.26 9.98 13 213246 675 79530454
Movement disorder 14.25 9.98 123 213136 27136 79503993
Myocardial infarction 14.23 9.98 379 212880 183750 79347379
Congestive hepatopathy 14.16 9.98 35 213224 4512 79526617
Crystalluria 14.16 9.98 15 213244 936 79530193
Bacterial infection 14.15 9.98 40 213219 31240 79499889
Selective mutism 14.15 9.98 6 213253 75 79531054
Flat affect 14.13 9.98 22 213237 2019 79529110
Encephalopathy 14.08 9.98 256 213003 67141 79463988
Cognitive disorder 14.05 9.98 264 212995 69662 79461467
Throat irritation 14.02 9.98 59 213200 40887 79490242
Haemodynamic instability 14.02 9.98 87 213172 17295 79513834
Haemorrhage 13.97 9.98 166 213093 90952 79440177
Hypergastrinaemia 13.96 9.98 8 213251 198 79530931
Cardiac murmur 13.91 9.98 81 213178 15743 79515386
Porphyria 13.88 9.98 8 213251 200 79530929
Lactate pyruvate ratio increased 13.87 9.98 6 213253 79 79531050
Anxiety disorder 13.87 9.98 33 213226 4154 79526975
Injection site haemorrhage 13.85 9.98 34 213225 27836 79503293
Alcohol intolerance 13.81 9.98 11 213248 474 79530655
Ischaemic stroke 13.81 9.98 44 213215 33087 79498042
Eye pruritus 13.79 9.98 21 213238 20549 79510580
Antasthmatic drug level 13.76 9.98 5 213254 40 79531089
Needle issue 13.74 9.98 9 213250 13059 79518070
Refusal of treatment by patient 13.74 9.98 54 213205 8937 79522192
Femoral nerve palsy 13.73 9.98 6 213253 81 79531048
Right ventricular dilatation 13.67 9.98 21 213238 1905 79529224
Chronic sinusitis 13.66 9.98 9 213250 13017 79518112
Acne 13.65 9.98 33 213226 27157 79503972
Sinus congestion 13.64 9.98 20 213239 19876 79511253
Panic reaction 13.58 9.98 35 213224 4630 79526499
Mood altered 13.57 9.98 88 213171 17759 79513370
Tooth hypoplasia 13.57 9.98 8 213251 209 79530920
Nephropathy toxic 13.54 9.98 21 213238 20398 79510731
Diabetes mellitus 13.53 9.98 139 213120 78251 79452878
Skin disorder 13.51 9.98 46 213213 33897 79497232
Food allergy 13.51 9.98 6 213253 10818 79520311
Therapy partial responder 13.45 9.98 16 213243 17381 79513748
Foetal exposure during pregnancy 13.45 9.98 40 213219 5750 79525379
Dry eye 13.41 9.98 52 213207 36879 79494250
Drug-device interaction 13.41 9.98 6 213253 86 79531043
Hepatic cytolysis 13.41 9.98 121 213138 27030 79504099
Blood loss anaemia 13.38 9.98 13 213246 15485 79515644
Injection site rash 13.37 9.98 17 213242 17937 79513192
Dermatitis acneiform 13.35 9.98 5 213254 9988 79521141
Breast cancer female 13.31 9.98 7 213252 11454 79519675
Communication disorder 13.29 9.98 32 213227 4058 79527071
Tenderness 13.26 9.98 27 213232 23615 79507514
Dysphoria 13.25 9.98 35 213224 4699 79526430
Analgesic drug level 13.24 9.98 5 213254 45 79531084
Lacrimation increased 13.18 9.98 25 213234 22452 79508677
Quadriparesis 13.15 9.98 29 213230 3472 79527657
Left ventricular hypertrophy 13.09 9.98 62 213197 11129 79520000
Lack of spontaneous speech 13.01 9.98 8 213251 226 79530903
Sudden cardiac death 13.00 9.98 37 213222 5188 79525941
Chronic fatigue syndrome 12.98 9.98 17 213242 1330 79529799
Uterine enlargement 12.96 9.98 14 213245 894 79530235
Pain of skin 12.91 9.98 12 213247 14601 79516528
Torticollis 12.87 9.98 23 213236 2364 79528765
Delusional disorder, unspecified type 12.85 9.98 13 213246 769 79530360
Cerebrovascular stenosis 12.83 9.98 7 213252 157 79530972
Distal intestinal obstruction syndrome 12.78 9.98 13 213246 774 79530355
Skull fractured base 12.76 9.98 9 213250 322 79530807
Cerebrospinal fluid leakage 12.73 9.98 19 213240 1680 79529449
Enterocolitis 12.73 9.98 12 213247 14500 79516629
Enuresis 12.72 9.98 27 213232 3149 79527980
Hip fracture 12.72 9.98 41 213218 30720 79500409
Metastases to lung 12.71 9.98 18 213241 18145 79512984
Inappropriate affect 12.70 9.98 18 213241 1518 79529611
Abdominal pain lower 12.70 9.98 43 213216 31739 79499390
Bone pain 12.68 9.98 92 213167 55650 79475479
Daydreaming 12.64 9.98 14 213245 919 79530210
Metastases to lymph nodes 12.61 9.98 6 213253 10391 79520738
Prostatic specific antigen increased 12.58 9.98 6 213253 10380 79520749
Aphthous ulcer 12.56 9.98 16 213243 16873 79514256
Bruxism 12.55 9.98 31 213228 3995 79527134
Head injury 12.54 9.98 154 213105 37215 79493914
Foaming at mouth 12.51 9.98 20 213239 1877 79529252
Dizziness 12.50 9.98 1225 212034 525216 79005913
Skin fissures 12.45 9.98 10 213249 13063 79518066
Protrusion tongue 12.44 9.98 10 213249 437 79530692
Emotional disorder of childhood 12.43 9.98 4 213255 21 79531108
Nervous system disorder 12.41 9.98 118 213141 26738 79504391
Urinary hesitation 12.41 9.98 32 213227 4234 79526895
Appendicitis 12.31 9.98 23 213236 20771 79510358
Kidney transplant rejection 12.29 9.98 6 213253 10240 79520889
Aplastic anaemia 12.27 9.98 18 213241 17887 79513242
Anticonvulsant drug level decreased 12.22 9.98 20 213239 1914 79529215
Hypoaesthesia oral 12.22 9.98 72 213187 14052 79517077
Drug level above therapeutic 12.22 9.98 51 213208 8672 79522457
Apraxia 12.22 9.98 25 213234 2842 79528287
Bundle branch block right 12.20 9.98 61 213198 11190 79519939
Arteriosclerosis 12.15 9.98 87 213172 18140 79512989
Thyroid adenoma 12.15 9.98 7 213252 175 79530954
Blood iron decreased 12.14 9.98 14 213245 15420 79515709
Wound infection 12.13 9.98 29 213230 23962 79507167
Lip dry 12.11 9.98 14 213245 15404 79515725
Pulmonary hypertension 12.11 9.98 77 213182 48003 79483126
Thoracic outlet syndrome 12.08 9.98 6 213253 110 79531019
Aplasia pure red cell 12.07 9.98 3 213256 7807 79523322
Blood citric acid increased 12.04 9.98 5 213254 59 79531070
Cerebral congestion 12.04 9.98 5 213254 59 79531070
Foetal death 12.04 9.98 48 213211 7996 79523133
Coma scale 11.90 9.98 5 213254 61 79531068
Respiratory tract congestion 11.87 9.98 22 213237 19932 79511197
Somatic symptom disorder 11.86 9.98 23 213236 2514 79528615
Tongue discolouration 11.86 9.98 29 213230 3714 79527415
Facial nerve disorder 11.86 9.98 12 213247 710 79530419
Abdominal distension 11.85 9.98 237 213022 119413 79411716
Gastric lavage 11.82 9.98 5 213254 62 79531067
Blood immunoglobulin M decreased 11.82 9.98 16 213243 1293 79529836
Hypophosphataemia 11.81 9.98 22 213237 19891 79511238
White blood cell count increased 11.80 9.98 272 212987 74361 79456768
Road traffic accident 11.78 9.98 173 213086 43491 79487638
Areflexia 11.71 9.98 37 213222 5497 79525632
Slow response to stimuli 11.71 9.98 19 213240 1806 79529323
Hyperaesthesia 11.69 9.98 64 213195 12158 79518971
Pericardial effusion 11.67 9.98 74 213185 46163 79484966
Ovarian cyst 11.65 9.98 10 213249 12645 79518484
Intraocular pressure increased 11.65 9.98 5 213254 9200 79521929
Post-traumatic stress disorder 11.60 9.98 34 213225 4847 79526282
Hereditary angioedema 11.59 9.98 36 213223 5299 79525830
Gastric disorder 11.58 9.98 56 213203 37377 79493752
Subdural haematoma 11.58 9.98 44 213215 31390 79499739
Pneumonia viral 11.55 9.98 5 213254 9153 79521976
Hyponatraemic coma 11.54 9.98 5 213254 66 79531063
Personal relationship issue 11.54 9.98 7 213252 193 79530936
Macroglossia 11.53 9.98 15 213244 1166 79529963
Myositis 11.52 9.98 21 213238 19147 79511982
Neurodegenerative disorder 11.51 9.98 10 213249 487 79530642
Intestinal perforation 11.48 9.98 18 213241 17408 79513721
Enterococcal infection 11.48 9.98 15 213244 15645 79515484
Chemical poisoning 11.47 9.98 7 213252 195 79530934
Drug resistance 11.47 9.98 66 213193 42147 79488982
Cerebral ataxia 11.46 9.98 4 213255 28 79531101
Intestinal pseudo-obstruction 11.41 9.98 23 213236 2586 79528543
Pneumonia fungal 11.41 9.98 8 213251 11202 79519927
Substance dependence 11.39 9.98 10 213249 494 79530635
Ocular hyperaemia 11.38 9.98 38 213221 28168 79502961
Withdrawal catatonia 11.38 9.98 7 213252 198 79530931
Breast cancer 11.37 9.98 49 213210 33732 79497397
Crime 11.35 9.98 5 213254 69 79531060
Second primary malignancy 11.31 9.98 13 213246 14337 79516792
Haematocrit decreased 11.30 9.98 107 213152 61205 79469924
Herbal interaction 11.25 9.98 10 213249 502 79530627
Terminal insomnia 11.18 9.98 15 213244 1202 79529927
Tonic clonic movements 11.17 9.98 21 213238 2243 79528886
Anticonvulsant drug level increased 11.15 9.98 23 213236 2630 79528499
Obstructive airways disorder 11.15 9.98 131 213128 31328 79499801
SARS-CoV-2 test positive 11.11 9.98 9 213250 11707 79519422
Change in seizure presentation 11.09 9.98 10 213249 512 79530617
Ventricular dyskinesia 11.08 9.98 9 213250 399 79530730
Formication 11.01 9.98 34 213225 4989 79526140
Anaesthesia 11.00 9.98 10 213249 517 79530612
Rash erythematous 11.00 9.98 100 213159 57669 79473460
Fistula 11.00 9.98 11 213248 12929 79518200
Tooth infection 11.00 9.98 21 213238 18811 79512318
Megacolon 10.99 9.98 27 213232 3468 79527661
Choreoathetosis 10.97 9.98 17 213242 1553 79529576
Ear infection 10.95 9.98 51 213208 34381 79496748
Hepatic cirrhosis 10.93 9.98 52 213207 34854 79496275
Gastrointestinal toxicity 10.93 9.98 4 213255 8105 79523024
Cholinergic syndrome 10.92 9.98 14 213245 1073 79530056
Head titubation 10.90 9.98 13 213246 925 79530204
Periorbital swelling 10.89 9.98 24 213235 2872 79528257
Electrocardiogram PR prolongation 10.87 9.98 17 213242 1566 79529563
Tarsal tunnel syndrome 10.86 9.98 10 213249 526 79530603
Akinesia 10.86 9.98 26 213233 3286 79527843
Lactic acidosis 10.86 9.98 128 213131 70231 79460898
Stereotypy 10.82 9.98 13 213246 932 79530197
Atopic keratoconjunctivitis 10.79 9.98 4 213255 34 79531095
Sensitivity to weather change 10.79 9.98 4 213255 8043 79523086
Device related infection 10.79 9.98 51 213208 34243 79496886
Pseudomonas infection 10.79 9.98 25 213234 20878 79510251
Herpes simplex 10.78 9.98 10 213249 12177 79518952
Muscle spasticity 10.76 9.98 96 213163 21379 79509750
Presyncope 10.72 9.98 65 213194 40989 79490140
Sexually inappropriate behaviour 10.72 9.98 10 213249 535 79530594
Gastric cancer 10.72 9.98 7 213252 10172 79520957
Drug dose titration not performed 10.71 9.98 12 213247 798 79530331
Muscle contractions involuntary 10.71 9.98 28 213231 3737 79527392
Duodenal ulcer 10.70 9.98 17 213242 16352 79514777
Physical abuse 10.69 9.98 4 213255 35 79531094
CSF lymphocyte count increased 10.65 9.98 3 213256 9 79531120
Metabolic syndrome 10.64 9.98 23 213236 2717 79528412
Hyporeflexia 10.63 9.98 27 213232 3541 79527588
Aspartate aminotransferase decreased 10.61 9.98 14 213245 1103 79530026
Neurological examination normal 10.59 9.98 4 213255 36 79531093
Kidney infection 10.59 9.98 27 213232 21824 79509305
Dissociative disorder 10.58 9.98 12 213247 809 79530320
Sickle cell anaemia with crisis 10.52 9.98 4 213255 7918 79523211
Orthopnoea 10.51 9.98 7 213252 10066 79521063
Neuromuscular toxicity 10.50 9.98 7 213252 228 79530901
Abdominal tenderness 10.49 9.98 56 213203 10538 79520591
Fear of disease 10.48 9.98 15 213244 1277 79529852
Blood ethanol increased 10.44 9.98 11 213248 682 79530447
Accident at work 10.44 9.98 14 213245 1121 79530008
Skin cancer 10.43 9.98 15 213244 15025 79516104
Abortion spontaneous 10.43 9.98 42 213217 29465 79501664
Squamous cell carcinoma 10.42 9.98 16 213243 15606 79515523
Moaning 10.42 9.98 14 213245 1123 79530006
Cor pulmonale acute 10.40 9.98 11 213248 685 79530444
Perforation bile duct 10.40 9.98 4 213255 38 79531091
Nasal polyps 10.39 9.98 43 213216 7284 79523845
Subileus 10.35 9.98 36 213223 5618 79525511
Increased appetite 10.33 9.98 61 213198 11917 79519212
Sciatic nerve injury 10.32 9.98 10 213249 561 79530568
Mesenteric vascular occlusion 10.31 9.98 5 213254 87 79531042
Tinnitus 10.20 9.98 171 213088 44162 79486967
Sinus rhythm 10.15 9.98 12 213247 846 79530283
Weight 10.14 9.98 4 213255 41 79531088
Gun shot wound 10.11 9.98 14 213245 1156 79529973
Intestinal infarction 10.09 9.98 15 213244 1321 79529808
Dermatitis bullous 10.08 9.98 14 213245 14231 79516898
Labelled drug-food interaction issue 10.05 9.98 4 213255 42 79531087
Hepatotoxicity 10.02 9.98 193 213066 51159 79479970
Musculoskeletal disorder 10.02 9.98 27 213232 21421 79509708
Stoma site ischaemia 9.98 9.98 3 213256 12 79531117
Oral tuberculosis 9.98 9.98 3 213256 12 79531117
Binge drinking 9.98 9.98 3 213256 12 79531117

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC N05BA01 NERVOUS SYSTEM
PSYCHOLEPTICS
ANXIOLYTICS
Benzodiazepine derivatives
FDA CS M0002356 Benzodiazepines
MeSH PA D000759 Adjuvants, Anesthesia
MeSH PA D000777 Anesthetics
MeSH PA D018686 Anesthetics, Intravenous
MeSH PA D014151 Anti-Anxiety Agents
MeSH PA D000927 Anticonvulsants
MeSH PA D000932 Antiemetics
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D018682 GABA Agents
MeSH PA D018757 GABA Modulators
MeSH PA D005765 Gastrointestinal Agents
MeSH PA D006993 Hypnotics and Sedatives
MeSH PA D009125 Muscle Relaxants, Central
MeSH PA D009465 Neuromuscular Agents
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D011619 Psychotropic Drugs
MeSH PA D014149 Tranquilizing Agents
FDA EPC N0000175694 Benzodiazepine
CHEBI has role CHEBI:35474 anti-anxiety agents
CHEBI has role CHEBI:35623 anticonvulsants
CHEBI has role CHEBI:35703 Xenobiotic
CHEBI has role CHEBI:35717 hypnotics
CHEBI has role CHEBI:78298 environmental contaminants

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Alcohol withdrawal delirium indication 8635005
Anxiety indication 48694002
Sedation indication 72641008
Tetanus indication 76902006 DOID:11338
Epilepsy indication 84757009 DOID:1826
Alcohol withdrawal syndrome indication 191480000
Spasticity indication 221360009
Status epilepticus indication 230456007 DOID:1824
Induce Anterograde Amnesia indication
Preoperative Anxiety indication
Panic disorder off-label use 371631005 DOID:594
Cocaine-Associated Acute Ischemic Heart Disease off-label use
Disorder of lung contraindication 19829001 DOID:850
Alcohol intoxication contraindication 25702006
Depressive disorder contraindication 35489007
Acute nephropathy contraindication 58574008
Hepatic failure contraindication 59927004
Substance abuse contraindication 66214007
Sleep apnea contraindication 73430006 DOID:0050847
Decreased respiratory function contraindication 80954004
Open-angle glaucoma contraindication 84494001 DOID:1067
Myasthenia gravis contraindication 91637004 DOID:437
Hypoalbuminemia contraindication 119247004
Disease of liver contraindication 235856003 DOID:409
Pregnancy, function contraindication 289908002
Severe chronic obstructive pulmonary disease contraindication 313299006
Angle-closure glaucoma contraindication 392291006 DOID:13550
Breastfeeding (mother) contraindication 413712001




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 3.06 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
10MG/SPRAY VALTOCO NEURELIS INC N211635 Jan. 10, 2020 RX SPRAY NASAL 8927497 July 21, 2025 NASAL ADMINISTRATION OF DIAZEPAM FOR TREATMENT OF INTERMITTENT, STEREOTYPIC EPISODES OF FREQUENT SEIZURE ACTIVITY IN PATIENTS 6 YEARS OF AGE AND OLDER
5MG/SPRAY VALTOCO NEURELIS INC N211635 Jan. 10, 2020 RX SPRAY NASAL 8927497 July 21, 2025 NASAL ADMINISTRATION OF DIAZEPAM FOR TREATMENT OF INTERMITTENT, STEREOTYPIC EPISODES OF FREQUENT SEIZURE ACTIVITY IN PATIENTS 6 YEARS OF AGE AND OLDER
7.5MG/SPRAY VALTOCO NEURELIS INC N211635 Jan. 10, 2020 RX SPRAY NASAL 8927497 July 21, 2025 NASAL ADMINISTRATION OF DIAZEPAM FOR TREATMENT OF INTERMITTENT, STEREOTYPIC EPISODES OF FREQUENT SEIZURE ACTIVITY IN PATIENTS 6 YEARS OF AGE AND OLDER

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
10MG/SPRAY VALTOCO NEURELIS INC N211635 Jan. 10, 2020 RX SPRAY NASAL Jan. 10, 2023 NEW PRODUCT
5MG/SPRAY VALTOCO NEURELIS INC N211635 Jan. 10, 2020 RX SPRAY NASAL Jan. 10, 2023 NEW PRODUCT
7.5MG/SPRAY VALTOCO NEURELIS INC N211635 Jan. 10, 2020 RX SPRAY NASAL Jan. 10, 2023 NEW PRODUCT
10MG/SPRAY VALTOCO NEURELIS INC N211635 Jan. 10, 2020 RX SPRAY NASAL Jan. 10, 2027 INDICATED FOR THE ACUTE TX OF INTERMITTENT, STEREOTYPIC EPISODES OF FREQUENT SEIZURE ACTIVITY (I.E. SEIZURE CLUSTERS, ACUTE REPETITIVE SEIZURES) THAT ARE DISTINCT FROM A PATIENT’S USUAL SEIZURE PATTERN IN PATIENTS WITH EPILEPSY 6 YEARS OF AGE AND OLDER
5MG/SPRAY VALTOCO NEURELIS INC N211635 Jan. 10, 2020 RX SPRAY NASAL Jan. 10, 2027 INDICATED FOR THE ACUTE TX OF INTERMITTENT, STEREOTYPIC EPISODES OF FREQUENT SEIZURE ACTIVITY (I.E. SEIZURE CLUSTERS, ACUTE REPETITIVE SEIZURES) THAT ARE DISTINCT FROM A PATIENT’S USUAL SEIZURE PATTERN IN PATIENTS WITH EPILEPSY 6 YEARS OF AGE AND OLDER
7.5MG/SPRAY VALTOCO NEURELIS INC N211635 Jan. 10, 2020 RX SPRAY NASAL Jan. 10, 2027 INDICATED FOR THE ACUTE TX OF INTERMITTENT, STEREOTYPIC EPISODES OF FREQUENT SEIZURE ACTIVITY (I.E. SEIZURE CLUSTERS, ACUTE REPETITIVE SEIZURES) THAT ARE DISTINCT FROM A PATIENT’S USUAL SEIZURE PATTERN IN PATIENTS WITH EPILEPSY 6 YEARS OF AGE AND OLDER

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
GABA A receptor alpha-5/beta-2/gamma-3 Ion channel POSITIVE ALLOSTERIC MODULATOR Ki 7.20 WOMBAT-PK CHEMBL
GABA-A receptor alpha-1/beta-2/gamma-2 Ion channel POSITIVE ALLOSTERIC MODULATOR EC50 7.14 WOMBAT-PK CHEMBL
GABA-A receptor alpha-2/beta-3/gamma-2 Ion channel POSITIVE ALLOSTERIC MODULATOR Ki 7.70 WOMBAT-PK CHEMBL
GABA-A receptor alpha-3/beta-3/gamma-2 Ion channel POSITIVE ALLOSTERIC MODULATOR Ki 7.65 WOMBAT-PK CHEMBL
GABA-A receptor alpha-5/beta-3/gamma-2 Ion channel POSITIVE ALLOSTERIC MODULATOR Ki 7.96 WOMBAT-PK CHEMBL
GABA-A receptor alpha-1/beta-2/gamma-3 Ion channel POSITIVE ALLOSTERIC MODULATOR Ki 6.71 WOMBAT-PK CHEMBL
GABA-A receptor alpha-1/beta-3/gamma-2 Ion channel POSITIVE ALLOSTERIC MODULATOR Ki 7.85 WOMBAT-PK CHEMBL
GABA A receptor alpha-3/beta-2/gamma-2 Ion channel POSITIVE ALLOSTERIC MODULATOR Ki 7.94 WOMBAT-PK CHEMBL
GABA A receptor alpha-3/beta-2/gamma-3 Ion channel POSITIVE ALLOSTERIC MODULATOR Ki 6.67 WOMBAT-PK CHEMBL
GABA A receptor alpha-5/beta-3/gamma-3 Ion channel POSITIVE ALLOSTERIC MODULATOR Ki 7.20 WOMBAT-PK CHEMBL
GABA A receptor alpha-5/beta-2/gamma-2 Ion channel POSITIVE ALLOSTERIC MODULATOR Ki 8.00 WOMBAT-PK CHEMBL
Gamma-aminobutyric acid receptor subunit alpha-5 Ion channel Kd 7.64 CHEMBL
Cytochrome P450 3A4 Enzyme Ki 4.42 WOMBAT-PK
Alpha-1A adrenergic receptor GPCR ALLOSTERIC MODULATOR Ki 4.10 IUPHAR
Adenosine receptor A3 GPCR IC50 7.92 CHEMBL
Aldo-keto reductase family 1 member C1 Enzyme IC50 5.25 CHEMBL
Aldo-keto reductase family 1 member C2 Enzyme IC50 5.62 CHEMBL
Aldo-keto reductase family 1 member C3 Enzyme IC50 4.08 CHEMBL
Cholinesterase Enzyme Ki 7.37 CHEMBL
Gamma-aminobutyric acid receptor subunit alpha-1 Ion channel Ki 7.96 CHEMBL
Gamma-aminobutyric acid receptor subunit alpha-2 Ion channel Ki 7.82 CHEMBL
Gamma-aminobutyric acid receptor subunit alpha-5 Ion channel Ki 8.01 CHEMBL
GABA A receptor alpha-6/beta-2/gamma-2 Ion channel Ki 8.68 CHEMBL
GABA-A receptor; alpha-1/beta-2/gamma-2 Ion channel Ki 7.92 CHEMBL
GABA-A receptor; anion channel Ion channel Ki 4.07 CHEMBL
GABA A receptor alpha-2/beta-2/gamma-2 Ion channel Ki 7.70 CHEMBL
GABA A receptor alpha-5/beta-3/gamma-2 Ion channel Ki 7.96 CHEMBL
GABA-A receptor; anion channel Ion channel Ki 8.54 CHEMBL
GABA-A receptor; anion channel Ion channel Ki 8 CHEMBL
GABA A receptor alpha-3/beta-2/gamma-2 Ion channel Ki 7.86 CHEMBL
Fatty acid-binding protein, liver Unclassified Ki 6.27 CHEMBL
Acetylcholinesterase Enzyme Ki 4.89 CHEMBL
Translocator protein Membrane receptor Kd 6.67 CHEMBL
Thyrotropin-releasing hormone receptor GPCR ANTAGONIST Ki 5.15 IUPHAR

External reference:

IDSource
4017796 VUID
N0000146157 NUI
D00293 KEGG_DRUG
202472 RXNORM
4017796 VANDF
C0012010 UMLSCUI
CHEBI:49575 CHEBI
DZP PDB_CHEM_ID
CHEMBL12 ChEMBL_ID
DB00829 DRUGBANK_ID
D003975 MESH_DESCRIPTOR_UI
3016 PUBCHEM_CID
3364 IUPHAR_LIGAND_ID
1295 INN_ID
Q3JTX2Q7TU UNII
3018 MMSL
4573 MMSL
894 MMSL
d00148 MMSL
001461 NDDF
387264003 SNOMEDCT_US
48546005 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Diazepam Intensol HUMAN PRESCRIPTION DRUG LABEL 1 0054-3185 SOLUTION, CONCENTRATE 5 mg ORAL ANDA 24 sections
Diazepam Intensol HUMAN PRESCRIPTION DRUG LABEL 1 0054-3185 SOLUTION, CONCENTRATE 5 mg ORAL ANDA 24 sections
Diazepam HUMAN PRESCRIPTION DRUG LABEL 1 0054-3188 SOLUTION 5 mg ORAL ANDA 26 sections
Diazepam HUMAN PRESCRIPTION DRUG LABEL 1 0054-3188 SOLUTION 5 mg ORAL ANDA 26 sections
Diazepam HUMAN PRESCRIPTION DRUG LABEL 1 0054-3188 SOLUTION 5 mg ORAL ANDA 26 sections
Diazepam HUMAN PRESCRIPTION DRUG LABEL 1 0121-0905 SOLUTION 5 mg ORAL ANDA 24 sections
Valium HUMAN PRESCRIPTION DRUG LABEL 1 0140-0004 TABLET 2 mg ORAL NDA 28 sections
Valium HUMAN PRESCRIPTION DRUG LABEL 1 0140-0004 TABLET 2 mg ORAL NDA 28 sections
Valium HUMAN PRESCRIPTION DRUG LABEL 1 0140-0005 TABLET 5 mg ORAL NDA 28 sections
Valium HUMAN PRESCRIPTION DRUG LABEL 1 0140-0005 TABLET 5 mg ORAL NDA 28 sections
Valium HUMAN PRESCRIPTION DRUG LABEL 1 0140-0006 TABLET 10 mg ORAL NDA 28 sections
Valium HUMAN PRESCRIPTION DRUG LABEL 1 0140-0006 TABLET 10 mg ORAL NDA 28 sections
Diazepam HUMAN PRESCRIPTION DRUG LABEL 1 0172-3925 TABLET 2 mg ORAL ANDA 16 sections
Diazepam HUMAN PRESCRIPTION DRUG LABEL 1 0172-3925 TABLET 2 mg ORAL ANDA 16 sections
Diazepam HUMAN PRESCRIPTION DRUG LABEL 1 0172-3926 TABLET 5 mg ORAL ANDA 16 sections
Diazepam HUMAN PRESCRIPTION DRUG LABEL 1 0172-3926 TABLET 5 mg ORAL ANDA 16 sections
Diazepam HUMAN PRESCRIPTION DRUG LABEL 1 0172-3927 TABLET 10 mg ORAL ANDA 16 sections
Diazepam HUMAN PRESCRIPTION DRUG LABEL 1 0172-3927 TABLET 10 mg ORAL ANDA 16 sections
Diastat HUMAN PRESCRIPTION DRUG LABEL 1 0187-0658 GEL 10 mg RECTAL NDA 20 sections
Diastat HUMAN PRESCRIPTION DRUG LABEL 1 0187-0658 GEL 10 mg RECTAL NDA 20 sections
Diastat HUMAN PRESCRIPTION DRUG LABEL 1 0187-0659 GEL 20 mg RECTAL NDA 20 sections
Diastat HUMAN PRESCRIPTION DRUG LABEL 1 0187-0659 GEL 20 mg RECTAL NDA 20 sections
Diazepam HUMAN PRESCRIPTION DRUG LABEL 1 0378-0271 TABLET 2 mg ORAL ANDA 29 sections
Diazepam HUMAN PRESCRIPTION DRUG LABEL 1 0378-0271 TABLET 2 mg ORAL ANDA 29 sections
Diazepam HUMAN PRESCRIPTION DRUG LABEL 1 0378-0271 TABLET 2 mg ORAL ANDA 29 sections
Diazepam HUMAN PRESCRIPTION DRUG LABEL 1 0378-0345 TABLET 5 mg ORAL ANDA 29 sections
Diazepam HUMAN PRESCRIPTION DRUG LABEL 1 0378-0345 TABLET 5 mg ORAL ANDA 29 sections
Diazepam HUMAN PRESCRIPTION DRUG LABEL 1 0378-0345 TABLET 5 mg ORAL ANDA 29 sections
Diazepam HUMAN PRESCRIPTION DRUG LABEL 1 0378-0477 TABLET 10 mg ORAL ANDA 29 sections
Diazepam HUMAN PRESCRIPTION DRUG LABEL 1 0378-0477 TABLET 10 mg ORAL ANDA 29 sections