azathioprine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
269 446-86-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • BW 57-322
  • azathioprine sulfate
  • azathioprine
  • azamune
  • azanin
  • azathioprin
  • azathropine
  • azothioprine
  • azathioprine sodium
Azathioprine is an inactive pro-drug of 6-mercaptopurine (6-MP), which acts as a purine antagonist but requires cellular uptake and intracellular anabolism to thioguanine nucleotides (TGNs) for immunosuppression. TGNs and other metabolites (e.g. 6-methylmercaptopurine ribonucleotides) inhibit de novo purine synthesis and purine nucleotide interconversions. The TGNs are also incorporated into nucleic acids and this contributes to the immunosuppressive effects of the medicinal product. Other potential mechanisms of azathioprine include the inhibition of many pathways in nucleic acid biosynthesis, hence preventing proliferation and activity of cells involved in the immune response (B and T lymphocytes). Because of these mechanisms, the therapeutic effect of azathioprine may be evident only after several weeks or months of treatment. Unlike 6-MP, the activity of the azathioprine metabolite 1-methyl-4-nitro-5-thioimidazole has not been clearly determined. However, compared with 6-MP it appears to modify the activity of azathioprine in several systems. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
  • Molecular weight: 277.26
  • Formula: C9H7N7O2S
  • CLOGP: 0.51
  • LIPINSKI: 0
  • HAC: 9
  • HDO: 1
  • TPSA: 115.42
  • ALOGS: -2.41
  • ROTB: 3
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.15 g O
0.15 g P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 10 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 1 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 18.03 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 60 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 0.020 High 1
caco2-efflux Caco-2 efflux ratio (BA/AB) 8.299 High 1
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 7.178 10^-6 cm/s High 1
dh-clint Dog hepatocyte intrinsic clearance 7.534 uL/min/10^6 cells High 1
dppb Dog plasma protein binding (% unbound) 50.980 % High 1
fcs-ppb Fetal calf serum protein binding (% unbound) 40.010 % High 1
herg hERG pIC50 4.299 pIC50 High 1
hh-clint Human hepatocyte intrinsic clearance 5.754 uL/min/10^6 cells High 1
hlm-clint Human liver microsomal intrinsic clearance 4.055 uL/min/mg protein High 1
hppb Human plasma protein binding (% unbound) 37.710 % High 1
kinase-safety-class ACVR2B,AURKA,AURKB,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EIF2AK3,ERBB2,FLT3,GRK2,ITK,MAP2K6,MAP3K21,MAPK10,MAPK7,MARK4,NTRK2,PDK1,PDK2,PDK4,PIK3CB,PIK3CD,PRKCD,PRKDC,SIK2,STK33,TEK,TTK 34
kinase-selectivity-class BRAF,CDK9,DYRK1B,ERBB2,GRK2,MAP2K6,MAP3K21 7
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 7.063 High 1
mh-clint Mouse hepatocyte intrinsic clearance 39.355 High 1
mppb Mouse plasma protein binding (% unbound) 58.610 High 1
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 3.311 High 1
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pppb Pig plasma protein binding (% unbound) 49.080 % High 1
rh-clint Rat hepatocyte intrinsic clearance 18.750 uL/min/10^6 cells High 1
rh-fuinc Rat hepatocyte fraction unbound in incubation 91.210 % High 1
rppb Rat plasma protein binding (% unbound) 25.010 % High 1
solubility-dd Solubility at pH 7.4 in DMSO 814.704 uM High 1

Approvals:

DateAgencyCompanyOrphan
Feb. 21, 2019 PMDA ASPEN JAPAN K.K.; MITSUBISHI TANABE PHARMA CORPORATION
March 20, 1968 FDA PROMETHEUS LABS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Off label use 696.27 9.69 5637 265142 1096615 89261053
Blood iron abnormal 563.92 9.69 264 270515 3756 90353912
Exposure during pregnancy 506.94 9.69 1716 269063 236694 90120974
Treatment failure 449.63 9.69 1949 268830 301979 90055689
Completed suicide 402.06 9.69 6 270773 145052 90212616
Death 394.78 9.69 470 270309 456081 89901587
Drug intolerance 375.35 9.69 2454 268325 445137 89912531
Drug ineffective 359.32 9.69 5959 264820 1378339 88979329
C-reactive protein increased 357.02 9.69 1273 269506 180116 90177552
Premature delivery 351.80 9.69 503 270276 38259 90319409
Liver function test increased 338.31 9.69 769 270010 84086 90273582
Bone erosion 331.47 9.69 580 270199 52441 90305227
Colitis ulcerative 302.56 9.69 600 270179 59666 90298002
Condition aggravated 290.38 9.69 2884 267895 592661 89765007
Lupus-like syndrome 286.92 9.69 520 270259 48326 90309342
Product dose omission issue 278.81 9.69 276 270503 291411 90066257
Maternal exposure during pregnancy 274.57 9.69 1929 268850 358134 89999534
Constipation 263.77 9.69 269 270510 280126 90077542
Inflammation 263.52 9.69 1145 269634 177447 90180221
Joint dislocation 259.82 9.69 473 270306 44109 90313559
Onychomadesis 257.96 9.69 480 270299 45518 90312150
Hepatic cirrhosis 255.18 9.69 576 270203 62677 90294991
Product label confusion 250.50 9.69 325 270454 22525 90335143
Malignant neoplasm progression 249.71 9.69 18 270761 106852 90250816
Toxicity to various agents 241.50 9.69 303 270476 287543 90070125
Hyponatraemia 241.25 9.69 52 270727 133486 90224182
Drug-induced liver injury 234.58 9.69 697 270082 89621 90268047
Fatigue 232.54 9.69 2268 268511 1151755 89205913
Grip strength decreased 231.56 9.69 705 270074 91871 90265797
Somnolence 231.24 9.69 172 270607 208912 90148756
Hypercholesterolaemia 229.07 9.69 743 270036 100149 90257519
Red blood cell sedimentation rate increased 227.57 9.69 651 270128 81944 90275724
Exostosis 226.88 9.69 495 270284 52639 90305029
Therapeutic product effect incomplete 225.36 9.69 1160 269619 192736 90164932
Hypotension 223.87 9.69 393 270386 325004 90032664
Fall 223.06 9.69 718 270061 481092 89876576
Anal fistula 221.70 9.69 146 270633 4155 90353513
Cytomegalovirus infection 220.80 9.69 331 270448 26271 90331397
Onychomycosis 217.10 9.69 396 270383 36980 90320688
Intestinal stenosis 216.12 9.69 130 270649 3144 90354524
Fistula 213.68 9.69 220 270559 11869 90345799
Post transplant lymphoproliferative disorder 212.48 9.69 172 270607 6777 90350891
Joint stiffness 208.14 9.69 608 270171 77434 90280234
Ileal stenosis 207.86 9.69 115 270664 2363 90355305
Hepatitis 207.09 9.69 570 270209 70169 90287499
Arthritis 204.96 9.69 1016 269763 166299 90191369
Back injury 204.39 9.69 439 270340 46183 90311485
Intentional product use issue 203.68 9.69 1225 269554 215667 90142001
Cushingoid 198.04 9.69 197 270582 10198 90347470
Retinitis 195.56 9.69 385 270394 38073 90319595
Foot deformity 194.20 9.69 500 270279 59151 90298517
Drug abuse 189.17 9.69 15 270764 82332 90275336
Drug level below therapeutic 188.63 9.69 149 270630 5665 90352003
Febrile neutropenia 187.35 9.69 121 270658 158228 90199440
Atrial fibrillation 181.36 9.69 86 270693 133525 90224143
Disease recurrence 180.75 9.69 368 270411 37285 90320383
Adverse reaction 180.47 9.69 321 270458 29391 90328277
Osteoporosis 174.22 9.69 659 270120 95872 90261796
Cerebrovascular accident 173.15 9.69 76 270703 123457 90234211
Cholestasis of pregnancy 171.40 9.69 87 270692 1490 90356178
Tremor 166.77 9.69 128 270651 153045 90204623
Finger deformity 165.66 9.69 328 270451 32569 90325099
Live birth 164.82 9.69 566 270213 78541 90279127
Demyelination 160.15 9.69 157 270622 7983 90349685
Rheumatoid arthritis 160.09 9.69 1722 269057 360892 89996776
Pre-eclampsia 160.06 9.69 181 270598 10867 90346801
Transplant rejection 159.83 9.69 194 270585 12564 90345104
SLE arthritis 158.96 9.69 65 270714 652 90357016
Cardiac failure congestive 152.75 9.69 52 270727 98642 90259026
Pain 152.32 9.69 2081 268698 994260 89363408
Faecal calprotectin increased 150.91 9.69 112 270667 3875 90353793
Seizure 147.37 9.69 143 270636 152486 90205182
Back pain 147.08 9.69 472 270307 316703 90040965
Intentional overdose 145.99 9.69 49 270730 93785 90263883
Syncope 145.52 9.69 110 270669 132553 90225115
Lupus nephritis 144.36 9.69 118 270661 4714 90352954
Therapeutic product effect decreased 143.54 9.69 1362 269417 276209 90081459
Premature labour 143.11 9.69 188 270591 13188 90344480
Normal newborn 142.66 9.69 253 270526 23109 90334559
Breast cancer stage III 142.17 9.69 564 270215 83883 90273785
Dyspnoea 141.85 9.69 1820 268959 879135 89478533
Hypokalaemia 138.41 9.69 113 270666 131003 90226665
Loss of consciousness 135.85 9.69 131 270648 140107 90217561
Neutrophil count decreased 135.14 9.69 25 270754 71507 90286161
Musculoskeletal stiffness 134.93 9.69 1417 269362 295115 90062553
Rheumatoid nodule 134.40 9.69 227 270552 19939 90337729
Product use in unapproved indication 133.94 9.69 1565 269214 334671 90022997
Platelet count decreased 133.78 9.69 127 270652 136842 90220826
Injection site pain 133.29 9.69 195 270584 173504 90184164
Nail disorder 133.13 9.69 434 270345 58633 90299035
Cough 131.85 9.69 610 270169 368352 89989316
Wound infection 131.57 9.69 648 270131 105754 90251914
C-reactive protein abnormal 128.11 9.69 733 270046 126696 90230972
Electrocardiogram QT prolonged 127.26 9.69 30 270749 72426 90285242
Large intestinal stenosis 126.85 9.69 84 270695 2413 90355255
Hyperhidrosis 126.68 9.69 132 270647 136173 90221495
Laryngitis 125.46 9.69 385 270394 50368 90307300
Coeliac disease 125.16 9.69 354 270425 44256 90313412
Osteoarthritis 123.22 9.69 1003 269776 194727 90162941
Anaemia 122.11 9.69 590 270189 352212 90005456
Anal abscess 121.55 9.69 115 270664 5593 90352075
Elbow deformity 120.95 9.69 68 270711 1443 90356225
Pancreatitis 120.48 9.69 470 270309 69356 90288312
Acute kidney injury 119.67 9.69 521 270258 319866 90037802
Injection site erythema 116.86 9.69 75 270704 98427 90259241
Sedation 115.80 9.69 7 270772 48164 90309504
Therapeutic response decreased 115.63 9.69 553 270226 89176 90268492
Crohn's disease 115.46 9.69 104 270675 4747 90352921
Epstein-Barr virus infection 114.74 9.69 148 270631 10196 90347472
Dehydration 114.55 9.69 257 270522 194190 90163478
Blood cholesterol increased 114.18 9.69 1034 269745 206978 90150690
Drug hypersensitivity 113.59 9.69 1981 268798 461628 89896040
Intestinal resection 112.53 9.69 83 270696 2844 90354824
Neuropathy peripheral 109.82 9.69 149 270630 136821 90220847
Cardio-respiratory arrest 109.21 9.69 27 270752 63113 90294555
Suicidal ideation 109.05 9.69 42 270737 73813 90283855
Depressed level of consciousness 108.11 9.69 41 270738 72743 90284925
Cardiac arrest 107.59 9.69 93 270686 104842 90252826
Balance disorder 107.09 9.69 80 270699 97000 90260668
Drug ineffective for unapproved indication 106.51 9.69 438 270341 66206 90291462
Suicide attempt 106.26 9.69 46 270733 75353 90282315
Joint range of motion decreased 105.06 9.69 730 270049 134913 90222755
Basal cell carcinoma 104.69 9.69 276 270503 33113 90324555
Frequent bowel movements 104.62 9.69 391 270388 56544 90301124
Ear infection 103.29 9.69 448 270331 69327 90288341
Lupus vulgaris 103.28 9.69 333 270446 44726 90312942
Neutropenia 102.60 9.69 337 270442 224567 90133101
Hallucination 101.63 9.69 35 270744 65924 90291744
Diffuse large B-cell lymphoma 101.12 9.69 127 270652 8518 90349150
Wrong technique in product usage process 100.33 9.69 44 270735 71527 90286141
Pneumocystis jirovecii pneumonia 99.89 9.69 208 270571 21408 90336260
Seronegative arthritis 99.37 9.69 188 270591 18046 90339622
Cytomegalovirus viraemia 99.36 9.69 118 270661 7468 90350200
Drug specific antibody present 98.63 9.69 101 270678 5413 90352255
Coma 98.16 9.69 47 270732 72585 90285083
Device expulsion 98.10 9.69 6 270773 40880 90316788
Impaired gastric emptying 97.32 9.69 153 270626 12656 90345012
Haemophagocytic lymphohistiocytosis 96.44 9.69 169 270610 15290 90342378
Panniculitis 95.36 9.69 162 270617 14296 90343372
Injection site swelling 95.28 9.69 30 270749 59809 90297859
Intentional product misuse 94.83 9.69 77 270702 89527 90268141
Proteinuria 93.79 9.69 212 270567 23079 90334589
Erythema nodosum 93.71 9.69 100 270679 5624 90352044
Feeling abnormal 92.91 9.69 228 270551 167007 90190661
Epstein-Barr virus associated lymphoproliferative disorder 92.27 9.69 71 270708 2596 90355072
Bursitis 91.85 9.69 691 270088 130963 90226705
Anal fissure 91.58 9.69 96 270683 5289 90352379
Bradycardia 91.33 9.69 70 270709 83777 90273891
Abscess 91.09 9.69 185 270594 18706 90338962
Blood glucose increased 91.04 9.69 90 270689 95156 90262512
Chronic obstructive pulmonary disease 90.64 9.69 54 270725 73775 90283893
Nausea 89.57 9.69 2581 268198 1107735 89249933
Thrombocytopenia 88.95 9.69 322 270457 208403 90149265
Kidney transplant rejection 88.76 9.69 90 270689 4767 90352901
Accidental exposure to product 88.73 9.69 11 270768 42355 90315313
Bone pain 88.65 9.69 37 270742 61946 90295722
Agitation 88.29 9.69 45 270734 67053 90290615
White blood cell count decreased 88.08 9.69 234 270545 166875 90190793
Fluid retention 87.99 9.69 80 270699 88011 90269657
Premature baby 87.66 9.69 216 270563 24861 90332807
Neoplasm progression 87.43 9.69 14 270765 44472 90313196
Synovitis 86.86 9.69 1426 269353 328326 90029342
Blepharospasm 86.71 9.69 362 270417 55083 90302585
Ulcer 86.51 9.69 255 270524 32627 90325041
Abortion spontaneous 85.38 9.69 354 270425 53702 90303966
Cognitive disorder 84.88 9.69 51 270728 69356 90288312
Serotonin syndrome 84.02 9.69 8 270771 37879 90319789
Pruritus 83.52 9.69 1128 269651 540397 89817271
Granulomatosis with polyangiitis 83.33 9.69 66 270713 2519 90355149
Granuloma skin 83.13 9.69 129 270650 10551 90347117
Orthostatic hypotension 82.57 9.69 13 270766 41814 90315854
Drug level decreased 82.07 9.69 122 270657 9608 90348060
Blood parathyroid hormone decreased 82.05 9.69 138 270641 12078 90345590
Injection site bruising 81.91 9.69 27 270752 52280 90305388
Rheumatic fever 80.88 9.69 755 270024 152366 90205302
Facet joint syndrome 78.83 9.69 534 270245 97855 90259813
Dry skin 78.81 9.69 88 270691 87985 90269683
Hepatosplenic T-cell lymphoma 78.05 9.69 39 270740 645 90357023
Lung disorder 77.15 9.69 735 270044 149148 90208520
Spondylitis 77.04 9.69 146 270633 14032 90343636
Scleritis 76.60 9.69 86 270693 5122 90352546
Vision blurred 75.93 9.69 133 270646 110160 90247508
Chest discomfort 75.02 9.69 191 270588 138174 90219494
Colectomy 73.93 9.69 69 270710 3298 90354370
Antinuclear antibody positive 73.86 9.69 113 270666 9128 90348540
Cytomegalovirus colitis 73.60 9.69 69 270710 3317 90354351
Ileocaecal resection 73.58 9.69 35 270744 517 90357151
Haematochezia 73.28 9.69 411 270368 70502 90287166
Psoriatic arthropathy 72.68 9.69 1020 269759 227315 90130353
Synovial fluid analysis 72.22 9.69 63 270716 2755 90354913
Ileostomy 71.97 9.69 54 270725 1900 90355768
Gait inability 71.36 9.69 710 270069 145746 90211922
Gastrointestinal lymphoma 71.02 9.69 21 270758 68 90357600
Neck pain 70.59 9.69 582 270197 113381 90244287
Overlap syndrome 70.41 9.69 106 270673 8442 90349226
Peripheral venous disease 69.96 9.69 460 270319 83461 90274207
Therapy interrupted 69.92 9.69 31 270748 50077 90307591
Diarrhoea haemorrhagic 69.69 9.69 119 270660 10544 90347124
Multiple sclerosis relapse 68.93 9.69 35 270744 52270 90305398
Drug tolerance decreased 68.75 9.69 232 270547 31898 90325770
Ileectomy 68.46 9.69 28 270751 281 90357387
Intentional self-injury 68.34 9.69 5 270774 29329 90328339
Macular degeneration 68.12 9.69 15 270764 37955 90319713
Hypoglycaemia 67.91 9.69 65 270714 69783 90287885
Lung transplant rejection 67.85 9.69 41 270738 1000 90356668
Palmar-plantar erythrodysaesthesia syndrome 67.57 9.69 4 270775 28019 90329649
Pleuritic pain 67.39 9.69 116 270663 10345 90347323
Pulmonary fibrosis 67.12 9.69 550 270229 106953 90250715
Mobility decreased 66.62 9.69 1086 269693 249648 90108020
Lip dry 66.57 9.69 523 270256 100432 90257236
Full blood count decreased 66.56 9.69 6 270773 29683 90327985
Device dislocation 66.36 9.69 8 270771 31474 90326194
Type 2 diabetes mellitus 66.33 9.69 912 269867 202332 90155336
Lactic acidosis 66.16 9.69 34 270745 50429 90307239
Dysgeusia 65.15 9.69 38 270741 52522 90305146
Skin exfoliation 65.10 9.69 64 270715 67849 90289819
Muscular weakness 64.88 9.69 921 269858 205745 90151923
Overdose 64.76 9.69 247 270532 157462 90200206
Vasculitis 64.55 9.69 181 270598 22512 90335156
Dyskinesia 64.40 9.69 15 270764 36519 90321149
Restlessness 64.30 9.69 14 270765 35706 90321962
Asthenia 64.28 9.69 1165 269614 532586 89825082
Myocardial infarction 64.08 9.69 138 270641 105834 90251834
Disseminated tuberculosis 63.73 9.69 63 270716 3236 90354432
Dislocation of vertebra 62.96 9.69 332 270447 55636 90302032
Tenosynovitis stenosans 62.85 9.69 68 270711 3885 90353783
Intestinal anastomosis 61.87 9.69 37 270742 885 90356783
Pulmonary embolism 61.74 9.69 193 270586 130627 90227041
Ankylosing spondylitis 61.42 9.69 127 270652 13006 90344662
Progressive multifocal leukoencephalopathy 61.38 9.69 141 270638 15514 90342154
Arthralgia 61.20 9.69 2877 267902 775645 89582023
Pleural effusion 61.16 9.69 154 270625 111837 90245831
Central nervous system lymphoma 60.79 9.69 50 270729 2015 90355653
Plasma cell myeloma 60.63 9.69 23 270756 40805 90316863
Skin necrosis 60.36 9.69 147 270632 16794 90340874
Hair follicle tumour benign 60.33 9.69 28 270751 390 90357278
Epistaxis 60.10 9.69 101 270678 85024 90272644
Respiratory arrest 60.08 9.69 13 270766 33298 90324370
Histoplasmosis disseminated 60.02 9.69 52 270727 2253 90355415
Urinary retention 59.95 9.69 19 270760 37725 90319943
Dysphonia 59.83 9.69 60 270719 63024 90294644
Gastrointestinal haemorrhage 59.29 9.69 112 270667 90136 90267532
Injection site reaction 59.05 9.69 474 270305 91606 90266062
Palpitations 58.85 9.69 210 270569 136518 90221150
Lymphoproliferative disorder 58.66 9.69 68 270711 4194 90353474
Pyoderma gangrenosum 57.75 9.69 69 270710 4395 90353273
Cardiac failure 57.17 9.69 154 270625 109342 90248326
Anti-neutrophil cytoplasmic antibody positive vasculitis 57.13 9.69 65 270714 3928 90353740
Hyperkalaemia 56.93 9.69 66 270713 64898 90292770
Foetal growth restriction 56.52 9.69 101 270678 9279 90348389
Angiocentric lymphoma 56.50 9.69 32 270747 689 90356979
Cardiac disorder 56.38 9.69 52 270727 56820 90300848
Dysarthria 56.19 9.69 48 270731 54434 90303234
Immunosuppressant drug level decreased 55.99 9.69 38 270741 1138 90356530
Disturbance in attention 55.69 9.69 36 270743 47073 90310595
Small intestinal resection 55.60 9.69 31 270748 647 90357021
Mucosal inflammation 55.58 9.69 54 270725 57571 90300097
Encephalopathy 55.58 9.69 35 270744 46409 90311259
Abdominal pain 54.47 9.69 1558 269221 394163 89963505
Mental status changes 54.39 9.69 33 270746 44646 90313022
Drug withdrawal syndrome 54.33 9.69 10 270769 28713 90328955
Unresponsive to stimuli 54.12 9.69 23 270756 38098 90319570
Rash erythematous 54.03 9.69 69 270710 65035 90292633
Blood calcium decreased 53.99 9.69 12 270767 30170 90327498
Metabolic acidosis 53.91 9.69 52 270727 55624 90302044
Transient ischaemic attack 53.82 9.69 31 270748 43145 90314523
Skin ulcer 53.58 9.69 293 270486 49782 90307886
Anxiety 53.37 9.69 630 270149 309142 90048526
Epilepsy 53.17 9.69 424 270355 81782 90275886
Clostridium difficile infection 53.08 9.69 232 270547 36013 90321655
Eye pruritus 53.02 9.69 11 270768 29016 90328652
Walking aid user 51.79 9.69 227 270552 35279 90322389
Visual impairment 51.66 9.69 614 270165 131751 90225917
Uveitis 51.43 9.69 133 270646 15770 90341898
Fibromyalgia 51.32 9.69 884 269895 205385 90152283
Pulmonary oedema 51.31 9.69 66 270713 62014 90295654
Gestational hypertension 51.02 9.69 54 270725 3008 90354660
Sinusitis 50.89 9.69 720 270059 342368 90015300
Lupus vasculitis 50.41 9.69 28 270751 580 90357088
Lethargy 50.28 9.69 69 270710 63070 90294598
Pulmonary tuberculosis 50.26 9.69 67 270712 4767 90352901
Gastrointestinal disorder 50.14 9.69 1060 269719 255627 90102041
Drug interaction 50.05 9.69 556 270223 275897 90081771
Squamous cell carcinoma 49.99 9.69 100 270679 10001 90347667
Adjustment disorder with depressed mood 49.69 9.69 315 270464 56438 90301230
Gastrointestinal inflammation 49.51 9.69 79 270700 6617 90351051
Leukopenia 49.42 9.69 489 270290 100221 90257447
Anti-cyclic citrullinated peptide antibody 49.21 9.69 186 270593 27035 90330633
Epstein-Barr virus associated lymphoma 49.04 9.69 29 270750 679 90356989
Listeriosis 48.81 9.69 41 270738 1702 90355966
Deep vein thrombosis 48.48 9.69 128 270651 91492 90266176
Grip strength 48.32 9.69 92 270687 8873 90348795
Autoimmune hepatitis 48.29 9.69 100 270679 10251 90347417
Obesity 48.28 9.69 505 270274 105002 90252666
Taste disorder 48.08 9.69 332 270447 61214 90296454
Osteonecrosis 48.02 9.69 180 270599 26061 90331607
Abdominal distension 48.01 9.69 599 270180 130002 90227666
Disorientation 47.82 9.69 37 270742 44077 90313591
Pneumonia aspiration 47.43 9.69 32 270747 40908 90316760
Hepatic enzyme increased 47.37 9.69 1412 269367 359324 89998344
Infusion related reaction 47.31 9.69 1603 269176 415177 89942491
Accidental overdose 47.15 9.69 13 270766 28260 90329408
Atypical mycobacterial infection 47.09 9.69 39 270740 1587 90356081
Vomiting 46.67 9.69 1904 268875 786389 89571279
Therapeutic reaction time decreased 46.43 9.69 56 270723 3602 90354066
Clear cell renal cell carcinoma 45.98 9.69 38 270741 1542 90356126
Tuberculosis 45.90 9.69 110 270669 12439 90345229
Intestinal obstruction 45.77 9.69 226 270553 36905 90320763
Intestinal fistula 45.54 9.69 32 270747 1015 90356653
Anaphylactic reaction 45.41 9.69 430 270349 87094 90270574
Aphthous ulcer 45.41 9.69 134 270645 17153 90340515
Gastrointestinal wall thickening 45.40 9.69 43 270736 2094 90355574
Device issue 44.94 9.69 16 270763 29521 90328147
Femur fracture 44.66 9.69 43 270736 46039 90311629
Serum sickness 44.59 9.69 54 270725 3488 90354180
Lymphopenia 44.43 9.69 160 270619 22721 90334947
Hot flush 44.43 9.69 68 270711 59420 90298248
Myasthenia gravis 44.38 9.69 76 270703 6749 90350919
Vertigo 43.81 9.69 89 270690 69722 90287946
International normalised ratio increased 43.74 9.69 46 270733 47270 90310398
Premature separation of placenta 43.59 9.69 44 270735 2318 90355350
Serositis 43.26 9.69 34 270745 1283 90356385
Hypoxia 43.17 9.69 95 270684 72304 90285364
Obstructive airways disorder 42.95 9.69 12 270767 25857 90331811
Pyrexia 42.85 9.69 1578 269201 658907 89698761
Body mass index abnormal 42.81 9.69 27 270752 712 90356956
Injection site pruritus 42.69 9.69 59 270720 53775 90303893
Rhinorrhoea 42.59 9.69 129 270650 88187 90269481
Product use issue 42.39 9.69 1288 269491 328631 90029037
Anti-cyclic citrullinated peptide antibody positive 42.24 9.69 964 269815 235469 90122199
Squamous cell carcinoma of skin 42.08 9.69 78 270701 7371 90350297
Paraesthesia oral 42.00 9.69 21 270758 31638 90326030
Food allergy 41.96 9.69 12 270767 25466 90332202
Creatinine renal clearance decreased 41.88 9.69 4 270775 18895 90338773
Illness 41.51 9.69 117 270662 81852 90275816
Chronic sinusitis 41.51 9.69 10 270769 23792 90333876
Joint swelling 41.40 9.69 1869 268910 501431 89856237
Immunosuppressant drug level increased 41.38 9.69 60 270719 4620 90353048
Splenic abscess 41.30 9.69 19 270760 259 90357409
Inappropriate antidiuretic hormone secretion 41.00 9.69 5 270774 19500 90338168
Sneezing 40.86 9.69 19 270760 29850 90327818
Metastases to central nervous system 40.84 9.69 3 270776 17539 90340129
Device difficult to use 40.79 9.69 3 270776 17522 90340146
Sleep apnoea syndrome 40.72 9.69 22 270757 31725 90325943
Dizziness 40.69 9.69 1397 269382 587887 89769781
Lacrimation increased 40.59 9.69 15 270764 27047 90330621
Contusion 40.57 9.69 518 270261 250698 90106970
Myasthenia gravis crisis 40.52 9.69 30 270749 1034 90356634
Dysphagia 40.40 9.69 185 270594 112093 90245575
Premature rupture of membranes 40.31 9.69 65 270714 5493 90352175
Low birth weight baby 40.17 9.69 88 270691 9379 90348289
Impaired work ability 39.99 9.69 138 270641 19188 90338480
Depressed mood 39.87 9.69 55 270724 50167 90307501
Sopor 39.87 9.69 12 270767 24632 90333036
Hypomagnesaemia 39.66 9.69 29 270750 35559 90322109
Inflammatory bowel disease 39.61 9.69 62 270717 5109 90352559
Hyperglycaemia 39.29 9.69 57 270722 50913 90306755
Epstein-Barr virus test positive 39.09 9.69 25 270754 676 90356992
Anaphylactic shock 38.98 9.69 23 270756 31594 90326074
Headache 38.89 9.69 2145 268634 860601 89497067
Contraindicated product administered 38.79 9.69 1241 269538 318898 90038770
Therapy cessation 38.78 9.69 31 270748 36330 90321338
Dermatitis atopic 38.76 9.69 11 270768 23461 90334207
Histoplasmosis 38.75 9.69 40 270739 2164 90355504
Mycobacterial infection 38.66 9.69 40 270739 2170 90355498
Angina pectoris 38.58 9.69 36 270743 39124 90318544
Metastases to bone 38.49 9.69 14 270765 25491 90332177
Haematoma 38.35 9.69 36 270743 39012 90318656
Chronic allograft nephropathy 38.18 9.69 26 270753 783 90356885
Night sweats 38.08 9.69 568 270211 128198 90229470
Subcutaneous abscess 37.91 9.69 70 270709 6596 90351072
Caesarean section 37.87 9.69 132 270647 18445 90339223
Diabetic ketoacidosis 37.51 9.69 13 270766 24394 90333274
Maternal exposure during breast feeding 37.51 9.69 67 270712 6153 90351515
Procedural pain 37.42 9.69 27 270752 33333 90324335
Oral pain 37.25 9.69 26 270753 32657 90325011
Prescribed underdose 37.16 9.69 365 270414 74654 90283014
Injection site mass 37.14 9.69 10 270769 22080 90335588
Arthritis enteropathic 37.04 9.69 20 270759 391 90357277
Dermatomyositis 37.04 9.69 48 270731 3322 90354346
Ejection fraction decreased 37.01 9.69 16 270763 26237 90331431
Blood glucose decreased 36.84 9.69 12 270767 23417 90334251
Therapeutic product effect variable 36.64 9.69 33 270746 1506 90356162
Liver injury 36.47 9.69 714 270065 169853 90187815
Cystitis 36.22 9.69 92 270687 66626 90291042
Rectal discharge 36.07 9.69 26 270753 859 90356809
Ileal ulcer 36.05 9.69 28 270751 1038 90356630
Diarrhoea 35.81 9.69 2372 268407 936818 89420850
Hip fracture 35.52 9.69 28 270751 33049 90324619
Episcleritis 35.42 9.69 29 270750 1161 90356507
Autoimmune disorder 35.42 9.69 368 270411 76376 90281292
Pollakiuria 35.37 9.69 28 270751 32977 90324691
Dyspnoea exertional 35.28 9.69 105 270674 72183 90285485
Liver transplant rejection 35.25 9.69 34 270745 1694 90355974
Renal failure 35.06 9.69 238 270541 130769 90226899
Burning sensation 34.84 9.69 87 270692 63365 90294303
Affect lability 34.79 9.69 6 270773 18057 90339611
Oxygen saturation decreased 34.70 9.69 184 270595 107299 90250369
Withdrawal syndrome 34.61 9.69 12 270767 22512 90335156
Tenosynovitis 34.60 9.69 109 270670 14458 90343210
Product storage error 34.34 9.69 9 270770 20232 90337436
Rhabdomyolysis 34.20 9.69 63 270716 51193 90306475
Speech disorder 34.14 9.69 52 270727 45533 90312135
Metastases to liver 34.07 9.69 22 270757 28785 90328883
Rebound effect 34.04 9.69 82 270697 9302 90348366
Spinal fusion surgery 33.99 9.69 97 270682 12186 90345482
Urinary tract infection 33.98 9.69 676 270103 304956 90052712
Disseminated cytomegaloviral infection 33.87 9.69 17 270762 284 90357384
Pulmonary nocardiosis 33.81 9.69 24 270755 774 90356894
Faecal calprotectin abnormal 33.73 9.69 15 270764 188 90357480
Muscle twitching 33.72 9.69 15 270764 24187 90333481
Nocardiosis 33.70 9.69 40 270739 2530 90355138
Plasmablastic lymphoma 33.60 9.69 16 270763 237 90357431
Mucous stools 33.37 9.69 58 270721 5213 90352455
Cholangitis sclerosing 33.22 9.69 37 270742 2184 90355484
Fear 33.19 9.69 5 270774 16617 90341051
Abnormal behaviour 33.18 9.69 13 270766 22615 90335053
Urinary incontinence 33.09 9.69 38 270741 37528 90320140
Nicotinic acid deficiency 33.09 9.69 12 270767 84 90357584
Coronary artery disease 33.02 9.69 31 270748 33592 90324076
Head injury 32.75 9.69 27 270752 31161 90326507
Nasal congestion 32.72 9.69 133 270646 83281 90274387
B-cell lymphoma 32.61 9.69 47 270732 3599 90354069
Eosinophilic granulomatosis with polyangiitis 32.55 9.69 39 270740 2491 90355177
Papilloma viral infection 32.53 9.69 33 270746 1749 90355919
Antiphospholipid syndrome 32.51 9.69 37 270742 2237 90355431
Injury 32.29 9.69 795 269984 196554 90161114
Laryngeal disorder 32.24 9.69 27 270752 1116 90356552
Hospitalisation 32.19 9.69 237 270542 127863 90229805
Pneumonia cytomegaloviral 32.16 9.69 43 270736 3068 90354600
Acute myocardial infarction 32.16 9.69 34 270745 34856 90322812
Aggression 32.04 9.69 20 270759 26648 90331020
Haematocrit decreased 32.03 9.69 47 270732 41785 90315883
Central nervous system lupus 32.00 9.69 29 270750 1334 90356334
Swollen tongue 32.00 9.69 55 270724 45901 90311767
Motor dysfunction 31.78 9.69 9 270770 19221 90338447
Poisoning 31.75 9.69 4 270775 15213 90342455
Crepitations 31.74 9.69 77 270702 8775 90348893
Antinuclear antibody negative 31.73 9.69 16 270763 270 90357398
Ear injury 31.73 9.69 17 270762 327 90357341
Intestinal anastomosis complication 31.63 9.69 17 270762 329 90357339
Nervousness 31.60 9.69 33 270746 34023 90323645
Musculoskeletal pain 31.43 9.69 701 270078 170550 90187118
Interstitial lung disease 31.40 9.69 358 270421 76047 90281621
Coombs positive haemolytic anaemia 31.17 9.69 19 270760 471 90357197
Flushing 31.13 9.69 147 270632 88344 90269324
Renal mass 31.11 9.69 38 270741 2477 90355191
Melaena 30.87 9.69 35 270744 34762 90322906
Drug level above therapeutic 30.55 9.69 59 270720 5750 90351918
Stoma closure 30.49 9.69 14 270765 190 90357478
Nocardia sepsis 30.48 9.69 8 270771 14 90357654
Congenital anomaly 30.41 9.69 62 270717 6285 90351383
Blood potassium increased 30.29 9.69 12 270767 20737 90336931
Hypogammaglobulinaemia 30.22 9.69 85 270694 10589 90347079
Hypocalcaemia 30.15 9.69 50 270729 42318 90315350
Injection site inflammation 30.10 9.69 51 270728 4490 90353178
Radiculopathy 29.96 9.69 9 270770 18496 90339172
Stenosis 29.94 9.69 34 270745 2050 90355618
Abdominal abscess 29.92 9.69 56 270723 5331 90352337
Altered state of consciousness 29.89 9.69 30 270749 31502 90326166
Blood potassium decreased 29.81 9.69 61 270718 47666 90310002
Secondary immunodeficiency 29.39 9.69 34 270745 2092 90355576
Upper gastrointestinal haemorrhage 29.35 9.69 16 270763 22960 90334708
Injection site warmth 29.31 9.69 8 270771 17507 90340161
Brain abscess 29.27 9.69 39 270740 2773 90354895
T-cell lymphoma 29.27 9.69 22 270757 776 90356892
Sinus disorder 29.11 9.69 36 270743 34411 90323257
Foetal exposure during pregnancy 29.07 9.69 224 270555 42751 90314917
Anaplastic large-cell lymphoma 29.07 9.69 11 270768 88 90357580
Ventricular tachycardia 29.04 9.69 19 270760 24689 90332979
Hypervolaemia 29.00 9.69 33 270746 32724 90324944
Product administration error 28.84 9.69 22 270757 26401 90331267
Vaginal discharge 28.84 9.69 11 270768 19453 90338215
Helicobacter infection 28.68 9.69 884 269895 225966 90131702
Intestinal fibrosis 28.66 9.69 14 270765 220 90357448
Hepatic cytolysis 28.64 9.69 30 270749 30886 90326782
Skin haemorrhage 28.63 9.69 14 270765 21366 90336302
Arthritis reactive 28.59 9.69 19 270760 549 90357119
Blood bilirubin increased 28.50 9.69 54 270725 43416 90314252
Diabetes mellitus 28.49 9.69 308 270471 64567 90293101
Anastomotic stenosis 28.49 9.69 17 270762 405 90357263
Subarachnoid haemorrhage 28.46 9.69 9 270770 17895 90339773
Natural killer-cell leukaemia 28.44 9.69 11 270768 94 90357574
Pericarditis 28.36 9.69 1030 269749 269121 90088547
Disease progression 28.31 9.69 315 270464 156300 90201368
Intentional dose omission 28.16 9.69 9 270770 17774 90339894
Fungal endocarditis 27.98 9.69 16 270763 351 90357317
Osteonecrosis of jaw 27.97 9.69 46 270733 39057 90318611
Loss of personal independence in daily activities 27.84 9.69 566 270213 135539 90222129
Sebaceous carcinoma 27.82 9.69 10 270769 68 90357600
Hyperthyroidism 27.72 9.69 10 270769 18300 90339368
Blood sodium decreased 27.66 9.69 25 270754 27588 90330080
Skin burning sensation 27.57 9.69 12 270767 19599 90338069
Arthropathy 27.50 9.69 1348 269431 364894 89992774
Fistula discharge 27.48 9.69 24 270755 1051 90356617
Combined immunodeficiency 27.45 9.69 12 270767 144 90357524
Anorectal disorder 27.28 9.69 32 270747 1999 90355669
Cardiogenic shock 27.19 9.69 20 270759 24448 90333220
Mycobacterium avium complex infection 27.13 9.69 46 270733 4052 90353616
Thiopurine methyltransferase decreased 27.12 9.69 15 270764 308 90357360
Polyomavirus viraemia 27.03 9.69 26 270753 1291 90356377
Hypophagia 26.91 9.69 41 270738 35896 90321772
Restless legs syndrome 26.79 9.69 17 270762 22453 90335215
Anal stenosis 26.79 9.69 18 270761 530 90357138
Injection site haemorrhage 26.78 9.69 27 270752 28291 90329377
Enterocutaneous fistula 26.66 9.69 28 270751 1546 90356122
Muscle fatigue 26.60 9.69 38 270741 2886 90354782
Product dose omission in error 26.60 9.69 14 270765 20489 90337179
Hiatus hernia 26.57 9.69 22 270757 25339 90332329
Nightmare 26.51 9.69 16 270763 21709 90335959
Toxic epidermal necrolysis 26.45 9.69 35 270744 32493 90325175
Device breakage 26.33 9.69 5 270774 14039 90343629
Antisynthetase syndrome 26.25 9.69 11 270768 118 90357550
Blood test abnormal 26.17 9.69 15 270764 20937 90336731
Therapy non-responder 26.17 9.69 563 270216 136141 90221527
Tinnitus 26.16 9.69 56 270723 43046 90314622
Jaw fracture 26.14 9.69 36 270743 2642 90355026
Neuromyelitis optica spectrum disorder 26.12 9.69 27 270752 1463 90356205
Sinus bradycardia 26.10 9.69 9 270770 16943 90340725
Chills 26.07 9.69 260 270519 131721 90225947
Hypothyroidism 26.04 9.69 77 270702 53050 90304618
Rectal abscess 25.97 9.69 27 270752 1473 90356195
Eye infection toxoplasmal 25.91 9.69 16 270763 406 90357262
Rectal cancer metastatic 25.82 9.69 14 270765 276 90357392
Aspergillus infection 25.72 9.69 81 270698 10742 90346926
JC virus infection 25.72 9.69 36 270743 2683 90354985
Immunosuppression 25.65 9.69 87 270692 11990 90345678
Discomfort 25.54 9.69 624 270155 273711 90083957
Intestinal dilatation 25.54 9.69 33 270746 2277 90355391
Rhegmatogenous retinal detachment 25.54 9.69 11 270768 127 90357541
Hallucination, auditory 25.44 9.69 8 270771 15967 90341701
Nephrotic syndrome 25.42 9.69 63 270716 7276 90350392
Enterovesical fistula 25.33 9.69 19 270760 668 90357000
Ganglioneuroma 25.31 9.69 11 270768 130 90357538
Hypertension 25.20 9.69 1637 269142 455895 89901773
Limb discomfort 25.20 9.69 47 270732 38013 90319655
Systemic lupus erythematosus 25.11 9.69 1322 269457 360574 89997094
Tractional retinal detachment 25.07 9.69 9 270770 61 90357607
Generalised tonic-clonic seizure 25.02 9.69 41 270738 34862 90322806
Muscle rigidity 24.97 9.69 6 270773 14303 90343365
Somatic delusion 24.94 9.69 18 270761 596 90357072
HELLP syndrome 24.93 9.69 24 270755 1193 90356475
Pancytopenia 24.89 9.69 501 270278 119762 90237906
Deep vein thrombosis postoperative 24.84 9.69 322 270457 70487 90287181
Transplant failure 24.76 9.69 30 270749 1939 90355729
Multiple epiphyseal dysplasia 24.75 9.69 10 270769 97 90357571
Pneumonitis 24.69 9.69 60 270719 44110 90313558
Dementia 24.63 9.69 21 270758 23840 90333828
Medication error 24.58 9.69 150 270629 84502 90273166
Emotional distress 24.51 9.69 45 270734 36617 90321051
Anal ulcer 24.47 9.69 20 270759 799 90356869
Blood pressure increased 24.45 9.69 428 270351 196789 90160879
Small intestinal stenosis 24.45 9.69 19 270760 705 90356963
Asthma 24.44 9.69 544 270235 241616 90116052
Cellulitis 24.40 9.69 166 270613 91171 90266497
Coordination abnormal 24.33 9.69 17 270762 21339 90336329
Hypoaesthesia 24.32 9.69 1160 269619 313050 90044618
Complications of bone marrow transplant 24.30 9.69 16 270763 455 90357213
Arterial occlusive disease 24.27 9.69 4 270775 12442 90345226
Social problem 24.24 9.69 24 270755 1235 90356433
Hallucination, visual 24.23 9.69 20 270759 23072 90334596
Aplasia pure red cell 24.02 9.69 50 270729 5144 90352524
Seasonal allergy 24.00 9.69 20 270759 22963 90334705
Folliculitis 23.91 9.69 789 269990 203564 90154104
Skeletal dysplasia 23.89 9.69 10 270769 107 90357561
Kaposi's sarcoma 23.78 9.69 11 270768 152 90357516
Delusion 23.77 9.69 6 270773 13834 90343834
Varicella zoster virus infection 23.68 9.69 42 270737 3835 90353833
Abdominal adhesions 23.66 9.69 40 270739 3515 90354153
Irritability 23.64 9.69 44 270735 35618 90322050
Extrapulmonary tuberculosis 23.60 9.69 15 270764 401 90357267
Lymphoedema 23.55 9.69 6 270773 13747 90343921
Limb injury 23.54 9.69 36 270743 31472 90326196
Anger 23.47 9.69 6 270773 13714 90343954
Multiple allergies 23.39 9.69 8 270771 15138 90342530
Skin laceration 23.30 9.69 26 270753 26009 90331659
Sciatica 23.24 9.69 429 270350 100953 90256715
Blood pressure abnormal 23.23 9.69 15 270764 19630 90338038
Nodular regenerative hyperplasia 23.23 9.69 18 270761 665 90357003
Chorioretinopathy 23.21 9.69 20 270759 860 90356808
Gestational diabetes 23.16 9.69 77 270702 10505 90347163
Defaecation urgency 23.14 9.69 55 270724 6187 90351481
Neoplasm skin 23.14 9.69 37 270742 3105 90354563
Presyncope 23.13 9.69 37 270742 31768 90325900
Anogenital warts 23.09 9.69 17 270762 581 90357087
Mydriasis 23.06 9.69 8 270771 15004 90342664
Bacterial pericarditis 23.04 9.69 6 270773 10 90357658
Maternal exposure timing unspecified 23.01 9.69 130 270649 22353 90335315
Confusional state 22.94 9.69 932 269847 385273 89972395
Pulmonary mass 22.94 9.69 156 270623 28616 90329052
Tuberculosis of central nervous system 22.86 9.69 14 270765 350 90357318
Complication associated with device 22.80 9.69 15 270764 19434 90338234
Pulmonary congestion 22.76 9.69 15 270764 19418 90338250
Trichodysplasia spinulosa 22.75 9.69 18 270761 686 90356982
Epicondylitis 22.56 9.69 33 270746 2561 90355107
Infectious mononucleosis 22.55 9.69 29 270750 1992 90355676
Loss of therapeutic response 22.53 9.69 27 270752 1725 90355943
Parkinsonism 22.48 9.69 7 270772 14058 90343610
Muscular dystrophy 22.44 9.69 8 270771 53 90357615
Nasal polyps 22.36 9.69 3 270776 10877 90346791
Tricuspid valve incompetence 22.34 9.69 11 270768 16720 90340948
Congenital osteodystrophy 22.34 9.69 7 270772 29 90357639
Tonsillitis 22.24 9.69 58 270721 6911 90350757
Opportunistic infection 22.20 9.69 30 270749 2163 90355505
Myoclonus 22.18 9.69 15 270764 19153 90338515
Infusion site reaction 22.14 9.69 114 270665 18925 90338743
Colectomy total 22.12 9.69 11 270768 180 90357488
Hypovolaemia 22.12 9.69 5 270774 12426 90345242
Decreased appetite 22.09 9.69 910 269869 375630 89982038
Allergy to chemicals 22.08 9.69 40 270739 3714 90353954
Abscess intestinal 22.04 9.69 28 270751 1900 90355768
Pneumocystis jirovecii infection 21.94 9.69 28 270751 1908 90355760
Rectal tenesmus 21.93 9.69 22 270757 1150 90356518
Feeling cold 21.88 9.69 30 270749 27435 90330233
Cytokine release syndrome 21.84 9.69 31 270748 27942 90329726
Synovial cyst 21.82 9.69 81 270698 11671 90345997
Retinal toxicity 21.80 9.69 24 270755 1398 90356270
Tuberculosis of eye 21.79 9.69 7 270772 32 90357636
Klebsiella infection 21.72 9.69 74 270705 10223 90347445
Immunodeficiency 21.67 9.69 62 270717 43172 90314496
Phospholipidosis 21.67 9.69 12 270767 247 90357421
Large intestine erosion 21.63 9.69 10 270769 138 90357530
Meningitis cryptococcal 21.55 9.69 27 270752 1806 90355862
Cardiotoxicity 21.47 9.69 4 270775 11385 90346283
Rash macular 21.30 9.69 36 270743 30244 90327424
Pregnancy 21.28 9.69 281 270498 61766 90295902
Complication of device insertion 21.16 9.69 3 270776 10433 90347235
Haematemesis 21.15 9.69 43 270736 33683 90323985
Anaplastic large cell lymphoma T- and null-cell types 21.04 9.69 8 270771 65 90357603
Arrhythmia 21.01 9.69 61 270718 42271 90315397
Skin neoplasm excision 20.98 9.69 26 270753 1720 90355948
Electrolyte imbalance 20.94 9.69 24 270755 23721 90333947
Eosinophilia 20.94 9.69 33 270746 28500 90329168
Tooth disorder 20.93 9.69 38 270741 31052 90326616
Retching 20.85 9.69 16 270763 19143 90338525
Neurotoxicity 20.84 9.69 20 270759 21447 90336221
Panic attack 20.80 9.69 29 270750 26336 90331332
Terminal ileitis 20.75 9.69 22 270757 1228 90356440
Infective pulmonary exacerbation of cystic fibrosis 20.74 9.69 3 270776 10276 90347392
Renal disorder 20.71 9.69 52 270727 37807 90319861
Injection site rash 20.71 9.69 25 270754 24148 90333520
Skin fissures 20.65 9.69 19 270760 20790 90336878
Mediastinal effusion 20.62 9.69 8 270771 69 90357599
Blood alkaline phosphatase increased 20.57 9.69 74 270705 48005 90309663
Steroid diabetes 20.57 9.69 31 270748 2471 90355197
Carcinoid tumour pulmonary 20.57 9.69 15 270764 505 90357163
Drug effective for unapproved indication 20.44 9.69 61 270718 7857 90349811
Weber tuning fork test abnormal 20.44 9.69 9 270770 110 90357558
Back disorder 20.41 9.69 28 270751 25603 90332065
Dysstasia 20.32 9.69 27 270752 25025 90332643
Hepatic fibrosis 20.26 9.69 41 270738 4134 90353534
Stress 20.25 9.69 151 270628 81244 90276424
Torsade de pointes 20.24 9.69 10 270769 15172 90342496
Foetal exposure timing unspecified 20.18 9.69 14 270765 435 90357233
Gastrointestinal scarring 20.18 9.69 14 270765 435 90357233
Congenital syphilitic osteochondritis 20.16 9.69 6 270773 20 90357648
Lipase increased 20.15 9.69 76 270703 11035 90346633
Salmonellosis 20.11 9.69 22 270757 1273 90356395
Jaundice cholestatic 20.10 9.69 3 270776 10040 90347628
Scleroderma renal crisis 20.09 9.69 14 270765 438 90357230
Varicella 20.09 9.69 30 270749 2372 90355296
Chest pain 19.93 9.69 767 270012 318878 90038790
Meningoencephalitis viral 19.92 9.69 13 270766 364 90357304
Extrapyramidal disorder 19.90 9.69 12 270767 16291 90341377
Heart transplant rejection 19.90 9.69 18 270761 826 90356842
Colostomy 19.80 9.69 22 270757 1295 90356373
Tuberculin test positive 19.79 9.69 38 270741 3687 90353981
Swelling face 19.72 9.69 152 270627 81200 90276468
Eye swelling 19.71 9.69 36 270743 29350 90328318
Wrist deformity 19.68 9.69 35 270744 3203 90354465
Product substitution issue 19.65 9.69 15 270764 17993 90339675
Enteropathic spondylitis 19.55 9.69 7 270772 47 90357621
Throat irritation 19.50 9.69 77 270702 48618 90309050
Infusion site thrombosis 19.46 9.69 10 270769 176 90357492
Psychotic disorder 19.43 9.69 40 270739 31190 90326478
Cerebral infarction 19.29 9.69 31 270748 26565 90331103
Blood calcium increased 19.27 9.69 6 270773 12052 90345616
Renal impairment 19.17 9.69 431 270348 104990 90252678
Abscess rupture 19.14 9.69 12 270767 313 90357355
Abnormal dreams 19.11 9.69 5 270774 11252 90346416
Injection site induration 19.05 9.69 4 270775 10464 90347204
Parvovirus B19 infection 19.04 9.69 19 270760 987 90356681
Lung abscess 19.03 9.69 28 270751 2185 90355483
Adjustment disorder 19.02 9.69 3 270776 9639 90348029
Myalgia 18.95 9.69 389 270390 174736 90182932
Oesophageal squamous cell carcinoma 18.86 9.69 9 270770 134 90357534
Akathisia 18.86 9.69 5 270774 11154 90346514
Glomerulonephritis proliferative 18.85 9.69 11 270768 251 90357417
Rectal stenosis 18.85 9.69 11 270768 251 90357417
Needle issue 18.85 9.69 9 270770 13925 90343743
Cutaneous tuberculosis 18.77 9.69 10 270769 190 90357478
Unevaluable event 18.77 9.69 92 270687 54756 90302912
Device malfunction 18.72 9.69 21 270758 20956 90336712
Herpes simplex hepatitis 18.70 9.69 15 270764 583 90357085
Full blood count abnormal 18.70 9.69 52 270727 36545 90321123
Breast cancer metastatic 18.67 9.69 11 270768 15121 90342547
Acute febrile neutrophilic dermatosis 18.64 9.69 36 270743 3509 90354159
Product administration interrupted 18.61 9.69 7 270772 12485 90345183
Gamma-glutamyltransferase increased 18.61 9.69 55 270724 37897 90319771
General physical health deterioration 18.54 9.69 1265 269514 353850 90003818
Pharyngeal oedema 18.47 9.69 9 270770 13762 90343906
Porokeratosis 18.33 9.69 9 270770 143 90357525
Glomerulosclerosis 18.33 9.69 14 270765 506 90357162
Adverse event 18.30 9.69 470 270309 116948 90240720
Right ventricular diastolic collapse 18.30 9.69 5 270774 11 90357657
Hypothermia 18.27 9.69 12 270767 15563 90342105
Hirsutism 18.24 9.69 24 270755 1686 90355982
Blood pressure fluctuation 18.23 9.69 238 270541 52175 90305493
Eructation 18.15 9.69 5 270774 10877 90346791
Hypercalcaemia 18.14 9.69 169 270610 34071 90323597
Poor venous access 18.10 9.69 110 270669 19417 90338251
Dyspepsia 18.06 9.69 744 270035 197416 90160252
Gait disturbance 18.06 9.69 617 270162 259879 90097789
Intestinal mucosal hypertrophy 18.03 9.69 11 270768 273 90357395
Mycobacterium abscessus infection 17.99 9.69 19 270760 1056 90356612
Anuria 17.96 9.69 11 270768 14807 90342861
Gangrene 17.91 9.69 8 270771 12868 90344800
Pallor 17.87 9.69 48 270731 34117 90323551
Mood altered 17.80 9.69 15 270764 17129 90340539
Campylobacter infection 17.80 9.69 20 270759 1192 90356476
Psychomotor hyperactivity 17.76 9.69 8 270771 12805 90344863
Diffuse large B-cell lymphoma stage I 17.72 9.69 5 270774 13 90357655
Rotator cuff syndrome 17.70 9.69 13 270766 15906 90341762
Cervical dysplasia 17.69 9.69 38 270741 3996 90353672
Gastrointestinal stenosis 17.68 9.69 11 270768 283 90357385
Hepatitis viral 17.61 9.69 15 270764 635 90357033
Lupus myocarditis 17.59 9.69 7 270772 65 90357603
Fistula of small intestine 17.59 9.69 13 270766 447 90357221
Atypical haemolytic uraemic syndrome 17.45 9.69 18 270761 973 90356695
Bursitis infective 17.37 9.69 22 270757 1488 90356180
Duodenal ulcer perforation 17.33 9.69 818 269961 220470 90137198
Body height decreased 17.30 9.69 7 270772 11942 90345726
Ventricular extrasystoles 17.26 9.69 9 270770 13241 90344427
Brachydactyly 17.23 9.69 10 270769 226 90357442
Hypokinesia 17.22 9.69 13 270766 15684 90341984
Trichostasis spinulosa 17.19 9.69 5 270774 15 90357653
Cavernous sinus thrombosis 17.19 9.69 10 270769 227 90357441
Proteus infection 17.19 9.69 22 270757 1504 90356164
Respiratory tract congestion 17.15 9.69 35 270744 27375 90330293
Perichondritis 17.05 9.69 7 270772 71 90357597
External auditory canal atresia 17.05 9.69 7 270772 71 90357597
Mantle cell lymphoma 17.04 9.69 15 270764 664 90357004
Cerebral toxoplasmosis 17.01 9.69 21 270758 1384 90356284
Cervix carcinoma stage 0 17.00 9.69 14 270765 565 90357103
Emotional disorder 17 9.69 12 270767 14985 90342683
Pneumatosis intestinalis 16.98 9.69 34 270745 3403 90354265
Aphasia 16.96 9.69 68 270711 42744 90314924
Neonatal respiratory distress syndrome 16.93 9.69 32 270747 3069 90354599
Nerve injury 16.92 9.69 6 270773 11100 90346568
Ischaemic stroke 16.88 9.69 25 270754 22141 90335527
Hyperadrenocorticism 16.85 9.69 13 270766 477 90357191
Small intestinal obstruction 16.85 9.69 115 270664 21119 90336549
Poor quality sleep 16.79 9.69 30 270749 24663 90333005
Thinking abnormal 16.78 9.69 7 270772 11725 90345943
Crying 16.69 9.69 32 270747 25613 90332055
Transient hypogammaglobulinaemia of infancy 16.67 9.69 6 270773 41 90357627
Bowel movement irregularity 16.64 9.69 50 270729 6464 90351204
Cytomegalovirus hepatitis 16.64 9.69 12 270767 397 90357271
Anal cancer 16.61 9.69 14 270765 584 90357084
X-ray abnormal 16.54 9.69 208 270571 45216 90312452
Abdominal pain lower 16.52 9.69 150 270629 30027 90327641
Pseudoxanthoma elasticum-like syndrome 16.50 9.69 4 270775 4 90357664
Mitochondrial neurogastrointestinal encephalopathy 16.50 9.69 4 270775 4 90357664
Blood urea increased 16.46 9.69 42 270737 30371 90327297
Cholesteatoma 16.44 9.69 9 270770 181 90357487
Hemiparesis 16.42 9.69 45 270734 31774 90325894
Mania 16.41 9.69 11 270768 14113 90343555
Hepatosplenomegaly 16.36 9.69 31 270748 2978 90354690
Peliosis hepatis 16.36 9.69 8 270771 126 90357542
Hydrops foetalis 16.31 9.69 14 270765 599 90357069
Left ventricular dysfunction 16.29 9.69 12 270767 14657 90343011
Malignant polyp 16.26 9.69 9 270770 185 90357483
Ventricular fibrillation 16.24 9.69 11 270768 14033 90343635
Cerebral haemorrhage 16.23 9.69 51 270728 34471 90323197
Rash maculo-papular 16.22 9.69 65 270714 40868 90316800
Small intestine carcinoma 16.19 9.69 13 270766 506 90357162
Complications of transplanted kidney 16.09 9.69 30 270749 2848 90354820
Necrotising herpetic retinopathy 16.08 9.69 8 270771 131 90357537
Myelitis 16.03 9.69 25 270754 2053 90355615
Kidney fibrosis 16.03 9.69 26 270753 2208 90355460
Mesenteritis 16.02 9.69 11 270768 336 90357332
Corynebacterium infection 16.00 9.69 17 270762 951 90356717
Spinal cord infection 15.95 9.69 15 270764 724 90356944
Dystonia 15.94 9.69 16 270763 16803 90340865
Rhinitis allergic 15.87 9.69 16 270763 16769 90340899
Acute respiratory failure 15.86 9.69 70 270709 42848 90314820
Cytomegalovirus chorioretinitis 15.81 9.69 27 270752 2392 90355276
Steroid dependence 15.73 9.69 26 270753 2243 90355425
Ocular sarcoidosis 15.72 9.69 7 270772 88 90357580
Thymoma 15.71 9.69 10 270769 268 90357400
Glycosylated haemoglobin increased 15.69 9.69 14 270765 15548 90342120
Lupus endocarditis 15.68 9.69 10 270769 269 90357399
Blood thyroid stimulating hormone increased 15.66 9.69 4 270775 9151 90348517
Actinomycotic skin infection 15.62 9.69 4 270775 6 90357662
Scratch 15.61 9.69 5 270774 9861 90347807
Subdural haematoma 15.59 9.69 16 270763 16629 90341039
Herpes simplex pneumonia 15.58 9.69 7 270772 90 90357578
Neuropsychiatric lupus 15.56 9.69 9 270770 202 90357466
Gastrointestinal fistula 15.55 9.69 13 270766 536 90357132
Complications of intestinal transplant 15.54 9.69 5 270774 23 90357645
Cholecystitis chronic 15.51 9.69 5 270774 9821 90347847
Congenital cytomegalovirus infection 15.50 9.69 8 270771 142 90357526
Renal transplant failure 15.48 9.69 18 270761 1114 90356554
Placental necrosis 15.36 9.69 5 270774 24 90357644
Anorectal stenosis 15.36 9.69 5 270774 24 90357644
Rash 15.31 9.69 2115 268664 793985 89563683
Aspergillosis oral 15.24 9.69 6 270773 54 90357614
Hospice care 15.21 9.69 5 270774 9699 90347969
Abdominal symptom 15.19 9.69 12 270767 456 90357212
Colitis ischaemic 15.19 9.69 9 270770 12337 90345331
Neuralgia 15.19 9.69 46 270733 31454 90326214
Eczema 15.18 9.69 94 270685 52776 90304892
Food intolerance 15.14 9.69 35 270744 3867 90353801
Haemorrhage in pregnancy 15.10 9.69 25 270754 2160 90355508
Short-bowel syndrome 15.09 9.69 14 270765 664 90357004
Oral lichen planus 15.08 9.69 15 270764 776 90356892
Myopathy 15.07 9.69 80 270699 13438 90344230
Injection site urticaria 15.04 9.69 19 270760 17992 90339676
Enterostomy 15.02 9.69 8 270771 152 90357516
Heart rate increased 14.97 9.69 242 270537 112660 90245008
Toxic skin eruption 14.96 9.69 15 270764 15759 90341909
Hepatocellular injury 14.91 9.69 41 270738 28917 90328751
B-cell unclassifiable lymphoma high grade 14.89 9.69 4 270775 8 90357660
Bronchomalacia 14.88 9.69 9 270770 220 90357448
Strongyloidiasis 14.84 9.69 21 270758 1581 90356087
Thrombotic microangiopathy 14.80 9.69 89 270690 15654 90342014
Hypersomnia 14.78 9.69 26 270753 21505 90336163
Spinal fracture 14.74 9.69 27 270752 21989 90335679
B-lymphocyte count decreased 14.72 9.69 20 270759 1449 90356219
Blood glucose abnormal 14.68 9.69 5 270774 9487 90348181
Renal tubular atrophy 14.65 9.69 16 270763 924 90356744
Multiple sclerosis 14.64 9.69 39 270740 27801 90329867
Product quality issue 14.64 9.69 325 270454 79000 90278668
Influenza like illness 14.62 9.69 162 270617 80449 90277219
Neurosyphilis 14.58 9.69 5 270774 29 90357639
Mediastinal abscess 14.58 9.69 5 270774 29 90357639
Adverse drug reaction 14.53 9.69 454 270325 116247 90241421
Epstein-Barr virus infection reactivation 14.49 9.69 21 270758 1616 90356052
Granuloma 14.43 9.69 46 270733 6139 90351529
Device related infection 14.43 9.69 35 270744 25751 90331917
Synovial disorder 14.40 9.69 30 270749 3088 90354580
Hereditary angioedema 14.37 9.69 5 270774 9360 90348308
Body temperature fluctuation 14.36 9.69 25 270754 2250 90355418
Haemoglobin decreased 14.36 9.69 371 270408 161585 90196083
Adenocarcinoma of the cervix 14.35 9.69 9 270770 235 90357433
Urinary casts present 14.33 9.69 7 270772 110 90357558
Paracoccidioides infection 14.28 9.69 4 270775 10 90357658
Lip swelling 14.25 9.69 63 270716 38547 90319121
Primary biliary cholangitis 14.22 9.69 19 270760 1355 90356313
Sinus tachycardia 14.21 9.69 41 270738 28472 90329196
Memory impairment 14.16 9.69 723 270056 196521 90161147
Bone marrow failure 14.16 9.69 153 270626 32068 90325600
American trypanosomiasis 14.12 9.69 9 270770 242 90357426
Skin abrasion 14.10 9.69 8 270771 11227 90346441
Joint effusion 14.04 9.69 104 270675 19606 90338062
Exercise tolerance increased 14.04 9.69 5 270774 33 90357635
Nerve compression 14.03 9.69 7 270772 10559 90347109
Squamous cell carcinoma of the oral cavity 14.00 9.69 11 270768 415 90357253
Cervix carcinoma 13.96 9.69 31 270748 3335 90354333
Oropharyngeal pain 13.95 9.69 251 270528 114936 90242732
Head discomfort 13.88 9.69 17 270762 16316 90341352
Germ cell cancer 13.80 9.69 6 270773 71 90357597
Congenital bowing of long bones 13.80 9.69 6 270773 71 90357597
Small intestine operation 13.79 9.69 5 270774 35 90357633
Vascular stenosis 13.77 9.69 12 270767 524 90357144
Acne conglobata 13.76 9.69 4 270775 12 90357656
Dyschezia 13.74 9.69 28 270751 2837 90354831
Impetigo 13.73 9.69 20 270759 1546 90356122
Microsporidia infection 13.73 9.69 10 270769 336 90357332
Chronic hepatitis 13.68 9.69 17 270762 1128 90356540
Skin discolouration 13.67 9.69 77 270702 44238 90313430
Muscle tightness 13.66 9.69 12 270767 13427 90344241
Apathy 13.65 9.69 8 270771 11032 90346636
Double stranded DNA antibody positive 13.64 9.69 11 270768 431 90357237
Enthesopathy 13.62 9.69 60 270719 9344 90348324
Herpes simplex reactivation 13.59 9.69 16 270763 1003 90356665
Hemiplegia 13.54 9.69 17 270762 16143 90341525
Uterine perforation 13.52 9.69 3 270776 7551 90350117
Eye ulcer 13.51 9.69 11 270768 437 90357231
Hepatitis E 13.49 9.69 22 270757 1877 90355791
Lung infiltration 13.49 9.69 85 270694 15197 90342471
Pyoderma 13.48 9.69 12 270767 539 90357129
Foot operation 13.48 9.69 5 270774 8996 90348672
Joint ankylosis 13.45 9.69 18 270761 1285 90356383
Flank pain 13.45 9.69 101 270678 19121 90338547
Ileocolostomy 13.44 9.69 5 270774 38 90357630
Bedridden 13.41 9.69 10 270769 12138 90345530
Cardiac murmur 13.39 9.69 21 270758 18173 90339495
Toothache 13.39 9.69 29 270750 22201 90335467
Ageusia 13.38 9.69 17 270762 16059 90341609
Tonsillar hypertrophy 13.36 9.69 17 270762 1155 90356513
Sacroiliitis 13.35 9.69 35 270744 4184 90353484
Diabetes mellitus inadequate control 13.34 9.69 22 270757 18662 90339006
Hypocomplementaemia 13.34 9.69 9 270770 267 90357401
Hepatic infection bacterial 13.32 9.69 5 270774 39 90357629
Mood swings 13.32 9.69 26 270753 20676 90336992
Oedema 13.28 9.69 477 270302 199818 90157850
Lymphadenitis bacterial 13.21 9.69 5 270774 40 90357628
Metastases to lung 13.21 9.69 17 270762 15974 90341694
Productive cough 13.14 9.69 157 270622 76906 90280762
Hypophosphataemia 13.11 9.69 15 270764 14839 90342829
Epiglottic erythema 13.09 9.69 6 270773 81 90357587
Complications of transplanted lung 13.08 9.69 10 270769 362 90357306
Cranial sutures widening 13.08 9.69 4 270775 15 90357653
Acute generalised exanthematous pustulosis 13.03 9.69 13 270766 13690 90343978
Drug tolerance 13.03 9.69 95 270684 17821 90339847
Vulval disorder 13.02 9.69 18 270761 1326 90356342
Atrial flutter 13.02 9.69 8 270771 10750 90346918
Agranulocytosis 12.99 9.69 57 270722 34945 90322723
Infusion site erythema 12.96 9.69 13 270766 13657 90344011
Rheumatoid lung 12.94 9.69 34 270745 4069 90353599
Visual acuity reduced 12.92 9.69 32 270747 23378 90334290
Large intestinal ulcer 12.91 9.69 33 270746 3884 90353784
Ureteral neoplasm 12.88 9.69 4 270775 16 90357652
Squamous cell carcinoma of the tongue 12.87 9.69 10 270769 371 90357297
Microangiopathic haemolytic anaemia 12.87 9.69 14 270765 805 90356863
Apnoea 12.86 9.69 6 270773 9408 90348260
Enteritis 12.85 9.69 63 270716 10258 90347410
DNA antibody 12.80 9.69 5 270774 44 90357624
Complex regional pain syndrome 12.77 9.69 26 270753 2633 90355035
Paronychia 12.77 9.69 4 270775 8002 90349666
Status epilepticus 12.77 9.69 23 270756 18851 90338817
Dermatitis allergic 12.75 9.69 20 270759 17307 90340361
Rash papular 12.73 9.69 26 270753 20329 90337339
Placental insufficiency 12.71 9.69 20 270759 1655 90356013
Tuberous sclerosis complex 12.71 9.69 6 270773 87 90357581
Histiocytic necrotising lymphadenitis 12.70 9.69 5 270774 45 90357623
Device leakage 12.70 9.69 7 270772 9984 90347684
Lymphocytopenia neonatal 12.68 9.69 4 270775 17 90357651
Epstein Barr virus positive mucocutaneous ulcer 12.68 9.69 12 270767 584 90357084
Respiration abnormal 12.66 9.69 4 270775 7959 90349709
Acute haemorrhagic ulcerative colitis 12.65 9.69 6 270773 88 90357580
Palatal ulcer 12.65 9.69 8 270771 212 90357456
Middle insomnia 12.65 9.69 19 270760 16732 90340936
Blood magnesium decreased 12.64 9.69 17 270762 15676 90341992
Aspiration 12.64 9.69 17 270762 15676 90341992
Appendicectomy 12.59 9.69 31 270748 3565 90354103
Body temperature increased 12.57 9.69 80 270699 44630 90313038
Dry mouth 12.47 9.69 671 270108 183388 90174280
Drug level abnormal 12.47 9.69 9 270770 298 90357370
Lymphocyte count decreased 12.46 9.69 58 270721 34992 90322676
Product dispensing error 12.43 9.69 11 270768 12262 90345406
Dysuria 12.41 9.69 68 270711 39333 90318335
Hepatic vein thrombosis 12.39 9.69 8 270771 220 90357448
HCoV-NL63 infection 12.38 9.69 3 270776 3 90357665
Faecaluria 12.38 9.69 3 270776 3 90357665
Pain of skin 12.38 9.69 18 270761 16064 90341604
Vaginal adenocarcinoma 12.38 9.69 3 270776 3 90357665
Congenital toxoplasmosis 12.38 9.69 3 270776 3 90357665
Abnormal faeces 12.36 9.69 46 270733 6636 90351032
Haemorrhage 12.34 9.69 140 270639 69229 90288439
Fasting 12.33 9.69 4 270775 19 90357649
Stress cardiomyopathy 12.32 9.69 13 270766 13342 90344326
Haemophilus infection 12.32 9.69 18 270761 1396 90356272
Peripheral coldness 12.29 9.69 14 270765 13878 90343790
Parosmia 12.27 9.69 3 270776 7066 90350602
Dermatofibrosarcoma protuberans 12.24 9.69 5 270774 50 90357618
Complement factor C3 decreased 12.24 9.69 9 270770 307 90357361
Infertility 12.21 9.69 14 270765 853 90356815
Bulimia nervosa 12.19 9.69 11 270768 503 90357165
Q fever 12.19 9.69 7 270772 155 90357513
Emphysema 12.18 9.69 11 270768 12144 90345524
Hand deformity 12.17 9.69 1036 269743 295326 90062342
Cafe au lait spots 12.16 9.69 4 270775 20 90357648
Salivary hypersecretion 12.11 9.69 6 270773 9086 90348582
Red blood cell sedimentation rate abnormal 12.10 9.69 118 270661 24086 90333582
Stevens-Johnson syndrome 12.05 9.69 46 270733 29330 90328338
Foot fracture 12.02 9.69 40 270739 26566 90331102
Dizziness postural 12.01 9.69 6 270773 9047 90348621
Impaired healing 11.99 9.69 833 269946 233366 90124302
Small intestinal perforation 11.92 9.69 21 270758 1908 90355760
Proctitis ulcerative 11.91 9.69 9 270770 320 90357348
Pyometra 11.91 9.69 6 270773 101 90357567
Breast adenoma 11.90 9.69 5 270774 54 90357614
Abnormal palmar/plantar creases 11.90 9.69 5 270774 54 90357614
Cataract 11.87 9.69 148 270631 71944 90285724
Blood pressure decreased 11.86 9.69 155 270624 74740 90282928
Angioimmunoblastic T-cell lymphoma 11.86 9.69 8 270771 237 90357431
Bipolar disorder 11.86 9.69 6 270773 8979 90348689
Enterocolonic fistula 11.82 9.69 5 270774 55 90357613
Central nervous system necrosis 11.80 9.69 7 270772 165 90357503
Epidermodysplasia verruciformis 11.80 9.69 7 270772 165 90357503
Therapy partial responder 11.78 9.69 109 270670 21934 90335734
Gastrointestinal ulcer 11.78 9.69 26 270753 2785 90354883
Porphyria acute 11.77 9.69 93 270686 17882 90339786
Vascular device infection 11.76 9.69 11 270768 11941 90345727
Anovulatory cycle 11.76 9.69 7 270772 166 90357502
Pulseless electrical activity 11.73 9.69 6 270773 8926 90348742
Alopecia universalis 11.72 9.69 7 270772 167 90357501
Lacrimal haemorrhage 11.70 9.69 4 270775 23 90357645
Inappropriate schedule of product administration 11.68 9.69 554 270225 149379 90208289
Scoliosis 11.68 9.69 6 270773 8901 90348767
Acid fast bacilli infection 11.60 9.69 6 270773 107 90357561
Upper-airway cough syndrome 11.59 9.69 17 270762 15118 90342550
Circulatory collapse 11.56 9.69 37 270742 24867 90332801
Pseudopolyposis 11.55 9.69 4 270775 24 90357644
Bradykinesia 11.55 9.69 3 270776 6785 90350883
Parathyroid disorder 11.53 9.69 13 270766 778 90356890
Eating disorder 11.49 9.69 44 270735 28029 90329639
Neoplasm malignant 11.43 9.69 153 270626 33727 90323941
Pulmonary necrosis 11.43 9.69 7 270772 175 90357493
Dermatopathic lymphadenopathy 11.42 9.69 4 270775 25 90357643
Abscess bacterial 11.41 9.69 8 270771 253 90357415
Drug specific antibody 11.40 9.69 24 270755 2488 90355180
Facial paralysis 11.36 9.69 18 270761 15516 90342152
Dissociation 11.36 9.69 3 270776 6712 90350956
Hyperbilirubinaemia 11.33 9.69 15 270764 13921 90343747
Cutaneous leishmaniasis 11.31 9.69 6 270773 113 90357555
Drug specific antibody absent 11.31 9.69 6 270773 113 90357555
Polymyositis 11.30 9.69 22 270757 2157 90355511
Bullous erysipelas 11.28 9.69 4 270775 26 90357642
Lymphocele 11.26 9.69 13 270766 798 90356870
Graft loss 11.24 9.69 10 270769 449 90357219
Metastases to lymph nodes 11.22 9.69 11 270768 11678 90345990
Sinus congestion 11.22 9.69 43 270736 27381 90330287
Blastomycosis 11.20 9.69 10 270769 451 90357217
Throat cancer 11.18 9.69 13 270766 804 90356864
Drug eruption 11.18 9.69 158 270621 35249 90322419
Faecal calprotectin 11.17 9.69 3 270776 6 90357662
Muir-Torre syndrome 11.16 9.69 4 270775 27 90357641
Gingival hypertrophy 11.15 9.69 22 270757 2178 90355490
Retinal vasculitis 11.15 9.69 18 270761 1523 90356145
Cardiomegaly 11.14 9.69 25 270754 18900 90338768
Stress at work 11.12 9.69 17 270762 1372 90356296
Respiratory syncytial virus infection 11.09 9.69 9 270770 10471 90347197
Sleep disorder due to general medical condition, insomnia type 11.09 9.69 296 270483 128398 90229270
Intestinal polyp 11.08 9.69 18 270761 1531 90356137
Scedosporium infection 11.07 9.69 13 270766 813 90356855
Peripheral sensory neuropathy 11.03 9.69 7 270772 9243 90348425
Swelling 11.02 9.69 1090 269689 417968 89939700
Pulmonary hypertension 11 9.69 78 270701 42445 90315223
Cholelithiasis 10.97 9.69 102 270677 52404 90305264
Breast pain 10.96 9.69 9 270770 10409 90347259
Meningitis listeria 10.96 9.69 12 270767 695 90356973
Spinal cord disorder 10.94 9.69 18 270761 1547 90356121
Periodontal inflammation 10.91 9.69 4 270775 29 90357639
Conjunctivitis 10.91 9.69 125 270654 26581 90331087
Proctalgia 10.90 9.69 51 270728 8147 90349521
Humerus fracture 10.87 9.69 8 270771 9777 90347891
Coronary artery occlusion 10.86 9.69 6 270773 8548 90349120
Toxic shock syndrome staphylococcal 10.86 9.69 3 270776 7 90357661
Cheilitis granulomatosa 10.86 9.69 3 270776 7 90357661
Histone antibody positive 10.86 9.69 7 270772 192 90357476
Portal venous gas 10.81 9.69 5 270774 69 90357599
Ophthalmic herpes zoster 10.81 9.69 25 270754 2763 90354905
Appetite disorder 10.77 9.69 7 270772 9126 90348542
Mental impairment 10.76 9.69 21 270758 16699 90340969
Purulent pericarditis 10.75 9.69 5 270774 70 90357598
Extra dose administered 10.73 9.69 7 270772 9111 90348557
Skin irritation 10.69 9.69 15 270764 13588 90344080
Anhedonia 10.69 9.69 11 270768 11420 90346248
Evans syndrome 10.69 9.69 9 270770 375 90357293
Superimposed pre-eclampsia 10.68 9.69 4 270775 31 90357637
Biopsy liver abnormal 10.67 9.69 8 270771 281 90357387
Actinic keratosis 10.66 9.69 27 270752 3161 90354507
Flatulence 10.64 9.69 76 270703 41291 90316377
Erythema 10.63 9.69 568 270211 228678 90128990
Anastomotic ulcer 10.63 9.69 11 270768 597 90357071
Lung neoplasm malignant 10.63 9.69 37 270742 24236 90333432
Leprosy 10.62 9.69 5 270774 72 90357596
Metastases to spinal cord 10.62 9.69 8 270771 283 90357385
Nocturia 10.62 9.69 9 270770 10246 90347422
Anterograde amnesia 10.61 9.69 11 270768 598 90357070
Extravasation blood 10.60 9.69 6 270773 129 90357539
Ill-defined disorder 10.60 9.69 664 270115 184227 90173441
Affective disorder 10.59 9.69 5 270774 7788 90349880
Skin lesion inflammation 10.58 9.69 3 270776 8 90357660
Listeria sepsis 10.56 9.69 12 270767 724 90356944
Sensory loss 10.54 9.69 24 270755 18051 90339617
Glomerulonephritis 10.53 9.69 23 270756 2447 90355221
Measles 10.50 9.69 9 270770 384 90357284
Toxoplasmosis 10.47 9.69 19 270760 1766 90355902
Central nervous system function test abnormal 10.47 9.69 4 270775 33 90357635
Renal cyst 10.46 9.69 14 270765 12936 90344732
Mammoplasty 10.46 9.69 12 270767 732 90356936
Retinal injury 10.41 9.69 9 270770 389 90357279
Subchorionic haematoma 10.40 9.69 6 270773 134 90357534
Paranoia 10.38 9.69 14 270765 12894 90344774
Pneumonia streptococcal 10.36 9.69 21 270758 2120 90355548
Gastritis haemorrhagic 10.36 9.69 19 270760 1781 90355887
Secondary adrenocortical insufficiency 10.35 9.69 22 270757 2296 90355372
Microtia 10.35 9.69 9 270770 392 90357276
Aortic arteriosclerosis 10.34 9.69 5 270774 7679 90349989
Gastroenteritis viral 10.34 9.69 51 270728 30304 90327364
Complement factor C4 decreased 10.34 9.69 8 270771 295 90357373
Primary effusion lymphoma 10.32 9.69 3 270776 9 90357659
Gastrointestinal erosion 10.31 9.69 12 270767 743 90356925
Polyhydramnios 10.29 9.69 23 270756 2485 90355183
Pseudopolyp 10.29 9.69 9 270770 395 90357273
Threatened labour 10.20 9.69 13 270766 885 90356783
Legionella infection 10.19 9.69 10 270769 509 90357159
Eye discharge 10.19 9.69 6 270773 8252 90349416
Bradyphrenia 10.17 9.69 5 270774 7607 90350061
Somnambulism 10.13 9.69 3 270776 6225 90351443
Stoma site extravasation 10.08 9.69 8 270771 306 90357362
Acinetobacter infection 10.08 9.69 20 270759 1988 90355680
Hodgkin's disease stage II 10.08 9.69 3 270776 10 90357658
Pulmonary cavitation 10.07 9.69 14 270765 1037 90356631
Atrioventricular block 10.06 9.69 7 270772 8808 90348860
Hypertensive crisis 10.06 9.69 24 270755 17760 90339908
JC virus granule cell neuronopathy 10.05 9.69 6 270773 143 90357525
Mesangioproliferative glomerulonephritis 9.99 9.69 5 270774 83 90357585
Gingivitis 9.97 9.69 8 270771 9361 90348307
Rheumatoid factor positive 9.94 9.69 617 270162 171033 90186635
Microscopic polyangiitis 9.91 9.69 7 270772 224 90357444
Meningitis tuberculous 9.91 9.69 11 270768 647 90357021
Diverticulum 9.88 9.69 13 270766 12100 90345568
Eyelid oedema 9.80 9.69 12 270767 11522 90346146
Quality of life decreased 9.80 9.69 65 270714 11824 90345844
Antineutrophil cytoplasmic antibody increased 9.80 9.69 7 270772 228 90357440
Adrenal insufficiency 9.78 9.69 51 270728 29870 90327798
Skin toxicity 9.77 9.69 4 270775 6775 90350893
Breath sounds abnormal 9.75 9.69 79 270700 15307 90342361
Sleep disorder 9.72 9.69 702 270077 197328 90160340
Dermatitis contact 9.71 9.69 16 270763 13579 90344089
Dysplasia 9.70 9.69 16 270763 1378 90356290

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Off label use 609.66 10.92 2970 94599 635365 41888401
Colitis ulcerative 573.35 10.92 477 97092 25698 42498068
Drug ineffective 554.56 10.92 2866 94703 627331 41896435
Death 355.95 10.92 334 97235 470851 42052915
Therapeutic product effect decreased 323.59 10.92 423 97146 38727 42485039
Hepatosplenic T-cell lymphoma 307.31 10.92 91 97478 415 42523351
Post transplant lymphoproliferative disorder 300.46 10.92 212 97357 8908 42514858
Intentional product use issue 289.01 10.92 558 97011 71275 42452491
Condition aggravated 288.10 10.92 1270 96299 259484 42264282
Treatment failure 286.38 10.92 514 97055 62110 42461656
Intestinal stenosis 276.64 10.92 133 97436 2671 42521095
Nodular regenerative hyperplasia 268.01 10.92 98 97471 950 42522816
Fistula 260.83 10.92 184 97385 7728 42516038
Drug eruption 241.75 10.92 281 97288 22794 42500972
Febrile neutropenia 213.78 10.92 79 97490 185624 42338142
Drug abuse 211.99 10.92 6 97563 104765 42419001
Anal abscess 210.10 10.92 161 97408 7689 42516077
Epstein-Barr virus infection 206.26 10.92 174 97395 9544 42514222
Eosinophilic granulomatosis with polyangiitis 196.50 10.92 161 97408 8477 42515289
Faecal calprotectin increased 196.11 10.92 109 97460 2985 42520781
Cytomegalovirus infection 194.32 10.92 300 97269 32006 42491760
Ileal stenosis 190.83 10.92 91 97478 1793 42521973
Vasculitis 189.34 10.92 222 97347 18172 42505594
Lymphoproliferative disorder 178.74 10.92 105 97464 3202 42520564
Diffuse large B-cell lymphoma 169.93 10.92 154 97415 9300 42514466
Anal fistula 169.73 10.92 129 97440 6084 42517682
Completed suicide 168.43 10.92 14 97555 96451 42427315
Toxicity to various agents 168.21 10.92 166 97403 228970 42294796
Fall 167.50 10.92 174 97395 234346 42289420
Pulmonary vasculitis 166.56 10.92 128 97441 6138 42517628
Malignant neoplasm progression 166.03 10.92 25 97544 108375 42415391
Hypotension 164.70 10.92 209 97360 257422 42266344
Frequent bowel movements 162.55 10.92 222 97347 21185 42502581
Disease recurrence 157.07 10.92 260 97309 29418 42494348
Neuritis 156.51 10.92 123 97446 6097 42517669
Drug ineffective for unapproved indication 146.04 10.92 325 97244 45838 42477928
Drug specific antibody present 143.37 10.92 98 97471 3908 42519858
Drug level below therapeutic 142.63 10.92 119 97450 6426 42517340
Premature baby 142.02 10.92 217 97352 22936 42500830
Ileocaecal resection 141.35 10.92 48 97521 366 42523400
Neurological symptom 140.23 10.92 142 97427 9849 42513917
Therapeutic product effect incomplete 139.93 10.92 418 97151 70521 42453245
JC virus infection 138.16 10.92 86 97483 2918 42520848
Hypersensitivity 137.65 10.92 421 97148 71949 42451817
Cytomegalovirus colitis 136.84 10.92 95 97474 3886 42519880
Drug level decreased 136.75 10.92 140 97429 9837 42513929
Acute kidney injury 136.63 10.92 411 97158 366926 42156840
Transplant rejection 136.53 10.92 162 97407 13426 42510340
Intestinal obstruction 135.83 10.92 232 97337 26926 42496840
Small intestinal stenosis 134.51 10.92 57 97512 840 42522926
Somnolence 134.49 10.92 78 97491 141027 42382739
Disseminated tuberculosis 132.80 10.92 82 97487 2742 42521024
Hepatic function abnormal 132.71 10.92 335 97234 51232 42472534
Large intestinal stenosis 129.48 10.92 71 97498 1892 42521874
Coombs positive haemolytic anaemia 129.21 10.92 61 97508 1174 42522592
Intestinal fistula 125.57 10.92 59 97510 1123 42522643
Abscess 123.99 10.92 158 97411 14090 42509676
Progressive multifocal leukoencephalopathy 121.66 10.92 141 97428 11395 42512371
Total lung capacity abnormal 120.81 10.92 92 97477 4351 42519415
Dizziness 119.86 10.92 244 97325 249010 42274756
Ileostomy 119.37 10.92 56 97513 1062 42522704
Colitis 117.18 10.92 300 97269 46272 42477494
Inappropriate schedule of product administration 116.94 10.92 482 97087 95420 42428346
Pneumocystis jirovecii pneumonia 114.12 10.92 206 97363 24975 42498791
Crohn's disease 113.96 10.92 76 97493 2908 42520858
Cushingoid 113.75 10.92 80 97489 3342 42520424
Acute febrile neutrophilic dermatosis 112.96 10.92 64 97505 1820 42521946
Squamous cell carcinoma 111.45 10.92 143 97426 12839 42510927
Confusional state 110.08 10.92 133 97436 167464 42356302
Leukopenia 107.66 10.92 396 97173 74350 42449416
Diarrhoea haemorrhagic 107.18 10.92 109 97460 7598 42516168
Basal cell carcinoma 105.61 10.92 188 97381 22545 42501221
Pulmonary alveolar haemorrhage 105.51 10.92 149 97420 14667 42509099
Blood pressure fluctuation 104.40 10.92 206 97363 26702 42497064
Nocardiosis 104.15 10.92 90 97479 5100 42518666
Lymphadenitis 103.31 10.92 67 97502 2444 42521322
Rebound effect 101.96 10.92 104 97465 7275 42516491
Spirometry abnormal 100.77 10.92 88 97481 5058 42518708
Kidney transplant rejection 98.12 10.92 110 97459 8573 42515193
Erythema nodosum 98.10 10.92 58 97511 1790 42521976
Respiratory symptom 97.96 10.92 124 97445 10982 42512784
Intentional overdose 97.06 10.92 5 97564 51451 42472315
Atrial fibrillation 96.82 10.92 106 97463 139487 42384279
Product use issue 96.11 10.92 389 97180 76362 42447404
Pulmonary tuberculosis 95.71 10.92 88 97481 5413 42518353
Myocardial infarction 95.38 10.92 86 97483 123923 42399843
Night sweats 95.16 10.92 167 97402 19802 42503964
Infusion related reaction 94.24 10.92 330 97239 60476 42463290
Hyponatraemia 93.95 10.92 58 97511 101404 42422362
Cardiac failure congestive 92.52 10.92 40 97529 85562 42438204
Conjunctivitis allergic 92.20 10.92 89 97480 5822 42517944
Product dose omission issue 90.66 10.92 133 97436 154232 42369534
Antineutrophil cytoplasmic antibody positive 90.25 10.92 77 97492 4288 42519478
Pulmonary fibrosis 90.22 10.92 193 97376 26488 42497278
Renal cell carcinoma 89.72 10.92 85 97484 5432 42518334
Hand deformity 89.42 10.92 72 97497 3696 42520070
Cytomegalovirus enteritis 89.25 10.92 39 97530 622 42523144
Mycotic allergy 88.54 10.92 80 97489 4811 42518955
Mite allergy 88.34 10.92 81 97488 4965 42518801
Bradycardia 87.65 10.92 43 97526 85441 42438325
Epstein-Barr virus associated lymphoproliferative disorder 85.62 10.92 59 97510 2384 42521382
Dehydration 85.36 10.92 120 97449 141647 42382119
Haemophagocytic lymphohistiocytosis 85.03 10.92 151 97418 18071 42505695
Dust allergy 84.52 10.92 81 97488 5251 42518515
Clear cell renal cell carcinoma 83.57 10.92 46 97523 1235 42522531
Terminal ileitis 82.39 10.92 36 97533 574 42523192
Squamous cell carcinoma of skin 79.05 10.92 120 97449 12606 42511160
Forced expiratory volume decreased 78.35 10.92 92 97477 7538 42516228
Anal fissure 78.19 10.92 77 97492 5162 42518604
Plasmablastic lymphoma 77.80 10.92 35 97534 600 42523166
Drug intolerance 77.51 10.92 377 97192 80047 42443719
Intestinal resection 77.33 10.92 50 97519 1814 42521952
Normochromic normocytic anaemia 76.76 10.92 99 97470 8932 42514834
Nodule 76.18 10.92 117 97452 12417 42511349
Overdose 75.13 10.92 78 97491 105186 42418580
Abdominal pain 73.57 10.92 712 96857 189759 42334007
Urticaria 72.74 10.92 349 97220 73687 42450079
Defaecation urgency 71.99 10.92 63 97506 3631 42520135
Weight increased 71.87 10.92 458 97111 107525 42416241
Dyspnoea 71.84 10.92 658 96911 441963 42081803
Epstein-Barr virus associated lymphoma 71.53 10.92 39 97530 1027 42522739
Tuberculosis 71.07 10.92 101 97468 9998 42513768
Blood glucose increased 69.80 10.92 41 97528 73658 42450108
Histoplasmosis disseminated 69.77 10.92 49 97520 2042 42521724
Weight decreased 69.66 10.92 755 96814 207193 42316573
Colectomy 69.51 10.92 51 97518 2278 42521488
Lymphopenia 69.50 10.92 153 97416 21410 42502356
Syncope 69.44 10.92 75 97494 99331 42424435
Herpes zoster 69.10 10.92 221 97348 38656 42485110
Cytokine release syndrome 68.76 10.92 10 97559 44517 42479249
Pain in extremity 67.80 10.92 582 96987 150022 42373744
Pancytopenia 67.34 10.92 481 97088 117262 42406504
Cardio-respiratory arrest 67.27 10.92 25 97544 58611 42465155
Cardiac failure 66.77 10.92 88 97481 106768 42416998
Human herpesvirus 8 infection 66.69 10.92 42 97527 1455 42522311
Meningitis listeria 66.66 10.92 32 97537 640 42523126
Lung transplant rejection 66.66 10.92 37 97532 1010 42522756
Haematochezia 65.97 10.92 287 97282 58149 42465617
Chronic obstructive pulmonary disease 65.83 10.92 31 97538 63083 42460683
Therapeutic response shortened 65.41 10.92 114 97455 13440 42510326
Cardiac arrest 65.32 10.92 93 97476 109227 42414539
Portal hypertension 65.28 10.92 67 97502 4720 42519046
Rheumatoid factor negative 65.02 10.92 36 97533 978 42522788
Oedema peripheral 63.79 10.92 135 97434 135941 42387825
Mycobacterium chelonae infection 62.60 10.92 37 97532 1141 42522625
Inflammatory bowel disease 62.46 10.92 57 97512 3472 42520294
Phaeohyphomycosis 62.43 10.92 37 97532 1147 42522619
Pemphigus 62.31 10.92 45 97524 1961 42521805
Gastrointestinal inflammation 62.13 10.92 64 97505 4528 42519238
Hypokalaemia 61.01 10.92 45 97524 71676 42452090
Therapy non-responder 60.95 10.92 263 97306 53096 42470670
Abdominal adhesions 60.88 10.92 42 97527 1700 42522066
Thrombotic microangiopathy 60.78 10.92 116 97453 14666 42509100
Neutrophil count decreased 60.44 10.92 35 97534 63380 42460386
B-cell lymphoma 60.29 10.92 65 97504 4848 42518918
Stomatitis 59.75 10.92 251 97318 50078 42473688
Aggression 59.46 10.92 14 97555 44149 42479617
Fistula discharge 59.40 10.92 35 97534 1073 42522693
Proctocolectomy 59.29 10.92 21 97548 184 42523582
Low birth weight baby 59.20 10.92 92 97477 9863 42513903
Epidermodysplasia verruciformis 59.05 10.92 23 97546 269 42523497
Hypoglycaemia 58.54 10.92 32 97537 59822 42463944
Coma 57.89 10.92 25 97544 53529 42470237
Delirium 57.60 10.92 24 97545 52495 42471271
Tachycardia 56.52 10.92 90 97479 100997 42422769
Cytomegalovirus viraemia 56.35 10.92 92 97477 10285 42513481
Capillaritis 55.92 10.92 44 97525 2184 42521582
Fatigue 55.87 10.92 684 96885 434957 42088809
T-cell lymphoma 55.54 10.92 34 97535 1119 42522647
Rash 55.30 10.92 389 97180 276565 42247201
Enterocutaneous fistula 55.23 10.92 35 97534 1226 42522540
Decreased appetite 55.10 10.92 241 97328 192896 42330870
Non-cirrhotic portal hypertension 55.02 10.92 24 97545 381 42523385
Foetal exposure during pregnancy 54.65 10.92 234 97335 47077 42476689
Epstein-Barr virus test positive 54.32 10.92 28 97541 656 42523110
Osteoporosis 54.09 10.92 111 97458 14795 42508971
Lymphocytopenia neonatal 53.73 10.92 12 97557 10 42523756
Heart transplant rejection 53.65 10.92 37 97532 1497 42522269
Arthralgia 53.28 10.92 710 96859 204528 42319238
Pneumonia aspiration 53.15 10.92 24 97545 50054 42473712
Kaposi's sarcoma 53.11 10.92 29 97540 766 42523000
Hallucination 53.04 10.92 33 97536 57474 42466292
Cerebrovascular accident 52.92 10.92 88 97481 97072 42426694
Electrocardiogram QT prolonged 52.44 10.92 22 97547 47923 42475843
Chronic allograft nephropathy 52.28 10.92 37 97532 1561 42522205
Asthenia 51.93 10.92 403 97166 280390 42243376
Clostridium difficile infection 51.91 10.92 141 97428 22518 42501248
Loss of consciousness 51.84 10.92 82 97487 92272 42431494
Wrong technique in product usage process 50.92 10.92 17 97552 42618 42481148
Immunosuppression 50.10 10.92 78 97491 8375 42515391
Neuropathy peripheral 49.45 10.92 99 97470 101754 42422012
Pancreatitis 49.21 10.92 213 97356 43055 42480711
Cutaneous T-cell lymphoma 49.17 10.92 39 97530 1959 42521807
Sedation 49.06 10.92 6 97563 30469 42493297
Drug level above therapeutic 49.04 10.92 64 97505 5842 42517924
Aspergillus infection 48.37 10.92 110 97459 15727 42508039
Gastrointestinal haemorrhage 48.30 10.92 94 97475 97632 42426134
Agitation 47.77 10.92 46 97523 64268 42459498
Dysgeusia 47.71 10.92 10 97559 34179 42489587
Drug tolerance decreased 47.50 10.92 41 97528 2319 42521447
Intentional product misuse 47.47 10.92 43 97526 61857 42461909
Hepatitis 47.43 10.92 154 97415 27146 42496620
Serotonin syndrome 47.24 10.92 3 97566 25842 42497924
Mycoplasma infection 47.21 10.92 25 97544 620 42523146
Polyhydramnios 47.19 10.92 19 97550 244 42523522
Loss of therapeutic response 47.19 10.92 32 97537 1259 42522507
Orthostatic hypotension 46.89 10.92 7 97562 30563 42493203
Urinary retention 46.76 10.92 19 97550 42195 42481571
International normalised ratio increased 46.74 10.92 26 97543 48142 42475624
Lymphoma 46.58 10.92 102 97467 14219 42509547
Product use in unapproved indication 46.58 10.92 635 96934 183821 42339945
Depressed level of consciousness 46.39 10.92 26 97543 47944 42475822
Small intestinal obstruction 46.13 10.92 113 97456 16948 42506818
Mucosal inflammation 45.99 10.92 28 97541 49346 42474420
Intestinal perforation 45.53 10.92 86 97483 10788 42512978
Constipation 45.37 10.92 204 97365 162087 42361679
Full blood count abnormal 45.28 10.92 161 97408 29715 42494051
Seizure 45.28 10.92 134 97435 120427 42403339
Epistaxis 44.77 10.92 284 97285 66542 42457224
Accidental overdose 44.59 10.92 6 97563 28324 42495442
Injection site pain 44.50 10.92 40 97529 57758 42466008
Transplant dysfunction 44.16 10.92 46 97523 3297 42520469
Migraine with aura 44.01 10.92 27 97542 892 42522874
Muscle spasms 43.78 10.92 342 97227 85702 42438064
Extrapulmonary tuberculosis 43.58 10.92 16 97553 157 42523609
Sleep disorder due to a general medical condition 43.43 10.92 112 97457 17341 42506425
Visceral leishmaniasis 43.13 10.92 29 97540 1125 42522641
Lactic acidosis 43.10 10.92 25 97544 45236 42478530
Abnormal behaviour 43.10 10.92 5 97564 26446 42497320
Transient ischaemic attack 42.91 10.92 12 97557 33727 42490039
Dry mouth 42.50 10.92 19 97550 39860 42483906
Cholangitis sclerosing 42.31 10.92 35 97534 1867 42521899
Food intolerance 42.20 10.92 33 97536 1623 42522143
Gait disturbance 42.02 10.92 102 97467 97898 42425868
Bone erosion 41.78 10.92 51 97518 4352 42519414
Suicide attempt 41.76 10.92 27 97542 46073 42477693
Haemolysis 41.60 10.92 77 97492 9512 42514254
Plasma cell myeloma 41.57 10.92 29 97540 47549 42476217
Pruritus 41.22 10.92 258 97311 188513 42335253
Red blood cell sedimentation rate abnormal 40.63 10.92 47 97522 3789 42519977
White blood cell count decreased 40.52 10.92 124 97445 110272 42413494
Abdominal abscess 40.45 10.92 54 97515 5039 42518727
Varicella zoster virus infection 40.26 10.92 39 97530 2562 42521204
Unresponsive to stimuli 40.26 10.92 11 97558 31392 42492374
Histoplasmosis 39.99 10.92 33 97536 1754 42522012
Peliosis hepatis 39.79 10.92 12 97557 59 42523707
Obstructive airways disorder 39.75 10.92 136 97433 24623 42499143
Angioedema 39.69 10.92 24 97545 42453 42481313
Gastrointestinal disorder 39.53 10.92 211 97358 46442 42477324
Disorientation 39.31 10.92 17 97552 36372 42487394
Fistula of small intestine 39.13 10.92 22 97547 616 42523150
Balance disorder 39.10 10.92 31 97538 47614 42476152
Rectal abscess 39.07 10.92 32 97537 1683 42522083
Anal stenosis 39.07 10.92 18 97551 327 42523439
Listeria sepsis 38.62 10.92 16 97553 222 42523544
Enteritis 38.60 10.92 80 97489 10736 42513030
Respiratory arrest 38.28 10.92 9 97560 28415 42495351
Large intestinal ulcer 38.25 10.92 37 97532 2426 42521340
Abscess intestinal 37.62 10.92 32 97537 1774 42521992
Gastrointestinal stoma complication 37.54 10.92 30 97539 1523 42522243
Foetal growth restriction 37.42 10.92 53 97516 5230 42518536
Hyperhidrosis 37.41 10.92 96 97473 90416 42433350
Pyoderma gangrenosum 37.24 10.92 33 97536 1934 42521832
Heart rate decreased 37.15 10.92 174 97395 36358 42487408
Vomiting 37 10.92 455 97114 289268 42234498
Drug interaction 36.92 10.92 412 97157 266587 42257179
Hyperkalaemia 36.70 10.92 81 97488 80377 42443389
Dyskinesia 36.32 10.92 7 97562 25383 42498383
Acute myocardial infarction 36.22 10.92 48 97521 58117 42465649
Splenomegaly 36.01 10.92 103 97466 16944 42506822
Myasthenia gravis crisis 35.85 10.92 23 97546 823 42522943
Mycobacterial infection 35.76 10.92 37 97532 2631 42521135
Epstein Barr virus positive mucocutaneous ulcer 35.67 10.92 20 97549 557 42523209
Gallbladder polyp 35.21 10.92 19 97550 490 42523276
General physical health deterioration 34.96 10.92 203 97366 151043 42372723
Biphasic mesothelioma 34.93 10.92 11 97558 64 42523702
Coronary artery disease 34.83 10.92 43 97526 53677 42470089
Nausea 34.73 10.92 670 96899 396129 42127637
Chromophobe renal cell carcinoma 34.65 10.92 11 97558 66 42523700
Cytomegalovirus infection reactivation 34.54 10.92 78 97491 11100 42512666
Rectal fissure 34.53 10.92 17 97552 360 42523406
Rhabdomyolysis 34.40 10.92 80 97489 77939 42445827
Granulomatosis with polyangiitis 34.33 10.92 28 97541 1464 42522302
Combined immunodeficiency 34.30 10.92 12 97557 101 42523665
Dry skin 34.26 10.92 36 97533 48302 42475464
Depression 34.18 10.92 135 97434 111228 42412538
Chest pain 34.02 10.92 184 97385 139346 42384420
Lupus-like syndrome 34.01 10.92 39 97530 3115 42520651
Arthropathy 33.87 10.92 146 97423 29451 42494315
Intestinal anastomosis 33.50 10.92 18 97551 460 42523306
Periumbilical abscess 33.45 10.92 11 97558 75 42523691
Hepatic enzyme increased 32.81 10.92 198 97371 45586 42478180
Musculoskeletal discomfort 32.55 10.92 69 97500 9407 42514359
C-reactive protein increased 32.52 10.92 253 97316 63307 42460459
Lymphocyte count abnormal 32.37 10.92 32 97537 2155 42521611
Insomnia 32.22 10.92 150 97419 118103 42405663
Polyomavirus-associated nephropathy 32.15 10.92 51 97518 5564 42518202
Gastrointestinal mucosa hyperaemia 32.03 10.92 16 97553 350 42523416
Product prescribing error 31.91 10.92 10 97559 26102 42497664
Lymphocyte count 31.88 10.92 14 97555 226 42523540
Disease progression 31.52 10.92 196 97373 143460 42380306
Hospitalisation 31.36 10.92 78 97491 74252 42449514
Malignant neoplasm of conjunctiva 31.33 10.92 9 97560 36 42523730
Hypocalcaemia 31.18 10.92 15 97554 30158 42493608
Gastrointestinal wall thickening 31.18 10.92 29 97540 1810 42521956
Drug resistance 31.15 10.92 158 97411 34090 42489676
Pouchitis 31.11 10.92 22 97547 927 42522839
Therapeutic response decreased 31.08 10.92 167 97402 36845 42486921
Neuroendocrine carcinoma of the skin 30.94 10.92 22 97547 935 42522831
Myopathy 30.89 10.92 85 97484 13676 42510090
Cardiac disorder 30.85 10.92 40 97529 48892 42474874
Intestinal ulcer 30.83 10.92 23 97546 1054 42522712
Jejunal stenosis 30.82 10.92 10 97559 65 42523701
Accidental exposure to product 30.52 10.92 5 97564 20388 42503378
Stiff person syndrome 30.47 10.92 13 97556 195 42523571
Infection reactivation 30.45 10.92 31 97538 2163 42521603
Liver transplant rejection 30.40 10.92 33 97536 2480 42521286
Limb deformity 30.28 10.92 18 97551 561 42523205
Chronic gastrointestinal bleeding 30.20 10.92 15 97554 324 42523442
Uveitis 30.18 10.92 66 97503 9192 42514574
Contusion 30.06 10.92 31 97538 41954 42481812
Nightmare 29.82 10.92 10 97559 25002 42498764
Pneumatosis intestinalis 29.78 10.92 45 97524 4707 42519059
Stenosis 29.73 10.92 30 97539 2071 42521695
Productive cough 29.64 10.92 211 97358 51356 42472410
Ventricular fibrillation 29.60 10.92 16 97553 30107 42493659
Amnesia 29.60 10.92 14 97555 28423 42495343
Pain 29.57 10.92 389 97180 244459 42279307
Herpes simplex 29.56 10.92 56 97513 7039 42516727
Cardiogenic shock 29.48 10.92 23 97546 35617 42488149
Hyperglycaemia 29.42 10.92 37 97532 45822 42477944
Bone marrow failure 28.94 10.92 151 97418 32942 42490824
Urinary tract infection 28.82 10.92 123 97446 99161 42424605
Rash maculo-papular 28.81 10.92 26 97543 37477 42486289
Angina pectoris 28.81 10.92 20 97549 32876 42490890
Full blood count decreased 28.72 10.92 6 97563 20554 42503212
Lung disorder 28.66 10.92 198 97371 47725 42476041
Obliterative bronchiolitis 28.64 10.92 25 97544 1436 42522330
Retinal scar 28.55 10.92 15 97554 366 42523400
Incorrect route of product administration 28.49 10.92 10 97559 24295 42499471
Meningitis meningococcal 28.30 10.92 10 97559 87 42523679
Cow pox 28.26 10.92 8 97561 30 42523736
Actinic keratosis 28.25 10.92 46 97523 5130 42518636
Arteriosclerosis 28.16 10.92 98 97471 17891 42505875
Toxic epidermal necrolysis 28.10 10.92 13 97556 26737 42497029
Haemoptysis 27.76 10.92 191 97378 45976 42477790
Latent tuberculosis 27.74 10.92 26 97543 1639 42522127
Intestinal anastomosis complication 27.71 10.92 12 97557 187 42523579
Gastrointestinal fistula 27.43 10.92 17 97552 572 42523194
Candida infection 27.39 10.92 110 97459 21500 42502266
Intestinal fibrosis 27.34 10.92 11 97558 141 42523625
Anorectal stenosis 27.28 10.92 7 97562 16 42523750
Metabolic acidosis 27.28 10.92 48 97521 51810 42471956
Cystitis escherichia 27.09 10.92 12 97557 198 42523568
Extrapyramidal disorder 26.99 10.92 3 97566 16409 42507357
Mental status changes 26.99 10.92 34 97535 42081 42481685
Memory impairment 26.86 10.92 46 97523 50176 42473590
Lupus nephritis 26.46 10.92 16 97553 515 42523251
Small intestine adenocarcinoma 26.40 10.92 12 97557 211 42523555
Stevens-Johnson syndrome 26.21 10.92 9 97560 22169 42501597
Rectal stenosis 26.14 10.92 12 97557 216 42523550
Irritability 26.13 10.92 16 97553 28112 42495654
Ejection fraction decreased 26.04 10.92 9 97560 22078 42501688
Pulmonary nocardiosis 25.87 10.92 26 97543 1786 42521980
Diffuse large B-cell lymphoma stage IV 25.86 10.92 16 97553 537 42523229
Dyspnoea exertional 25.85 10.92 47 97522 50101 42473665
Gastrointestinal stenosis 25.84 10.92 11 97558 164 42523602
Congenital cytomegalovirus infection 25.67 10.92 7 97562 22 42523744
Optic neuritis 25.64 10.92 39 97530 4103 42519663
Anorectal disorder 25.54 10.92 22 97547 1241 42522525
Gastrointestinal lymphoma 25.52 10.92 10 97559 119 42523647
Bronchopulmonary aspergillosis 25.51 10.92 100 97469 19329 42504437
Platelet count decreased 25.51 10.92 199 97370 138382 42385384
Chronic myeloid leukaemia 25.51 10.92 30 97539 2462 42521304
Transverse sinus thrombosis 25.50 10.92 9 97560 78 42523688
Hepatic cytolysis 25.31 10.92 15 97554 26829 42496937
Immunosuppressant drug level increased 25.07 10.92 55 97514 7676 42516090
Tonsil cancer 25.07 10.92 21 97548 1140 42522626
Disturbance in attention 25.05 10.92 19 97550 29847 42493919
Pneumoperitoneum 24.96 10.92 29 97540 2349 42521417
Hepatotoxicity 24.95 10.92 119 97450 25048 42498718
Eosinophilic bronchitis 24.82 10.92 12 97557 244 42523522
Faecal calprotectin abnormal 24.78 10.92 13 97556 316 42523450
Angiolymphoid hyperplasia with eosinophilia 24.73 10.92 10 97559 130 42523636
Lung neoplasm 24.69 10.92 41 97528 4647 42519119
Hypervolaemia 24.66 10.92 11 97558 23114 42500652
Therapeutic reaction time decreased 24.64 10.92 27 97542 2051 42521715
Myasthenic syndrome 24.55 10.92 18 97551 803 42522963
Drug specific antibody 24.49 10.92 14 97555 405 42523361
Ileal ulcer 24.47 10.92 19 97550 925 42522841
Growth retardation 24.43 10.92 29 97540 2403 42521363
Blood creatine phosphokinase increased 24.30 10.92 46 97523 48292 42475474
Body temperature fluctuation 24.19 10.92 24 97545 1623 42522143
Epstein-Barr viraemia 24.17 10.92 28 97541 2261 42521505
Suicidal ideation 24.06 10.92 46 97523 48115 42475651
Altered state of consciousness 24.05 10.92 19 97550 29240 42494526
Neutropenia 24.01 10.92 317 97252 199114 42324652
Pulmonary oedema 23.98 10.92 54 97515 53218 42470548
Psychotic disorder 23.97 10.92 19 97550 29189 42494577
Aphthous ulcer 23.88 10.92 46 97523 5855 42517911
Molluscum contagiosum 23.79 10.92 13 97556 344 42523422
Neoplasm progression 23.63 10.92 19 97550 28981 42494785
Osteonecrosis 23.61 10.92 85 97484 15780 42507986
Cognitive disorder 23.60 10.92 26 97543 34146 42489620
Urinary incontinence 23.60 10.92 10 97559 21658 42502108
Granuloma 23.55 10.92 37 97532 4004 42519762
Inflammation 23.38 10.92 145 97424 33702 42490064
Diabetic ketoacidosis 23.29 10.92 11 97558 22356 42501410
Complications of transplanted kidney 23.26 10.92 43 97526 5307 42518459
Marrow hyperplasia 23.19 10.92 21 97548 1266 42522500
Acquired gene mutation 23.17 10.92 23 97546 1557 42522209
Parvovirus B19 infection 23.16 10.92 24 97545 1710 42522056
Squamous cell carcinoma of the tongue 23.16 10.92 13 97556 363 42523403
Medication error 23.15 10.92 25 97544 33129 42490637
Proctitis 23.14 10.92 31 97538 2902 42520864
Hypothyroidism 23.14 10.92 139 97430 31945 42491821
Limb discomfort 23.06 10.92 73 97496 12694 42511072
Ventricular tachycardia 23.06 10.92 21 97548 30139 42493627
Non-Hodgkin's lymphoma 22.97 10.92 22 97547 1425 42522341
Small intestine carcinoma 22.92 10.92 16 97553 660 42523106
Anaemia 22.75 10.92 479 97090 279799 42243967
Autoimmune haemolytic anaemia 22.69 10.92 44 97525 5627 42518139
Butterfly rash 22.68 10.92 9 97560 111 42523655
Scleroderma 22.66 10.92 24 97545 1754 42522012
Adenocarcinoma 22.66 10.92 26 97543 2078 42521688
Haematuria 22.59 10.92 63 97506 57736 42466030
Cytomegalovirus chorioretinitis 22.53 10.92 39 97530 4572 42519194
Lymphadenopathy 22.46 10.92 142 97427 33223 42490543
Legionella infection 22.35 10.92 15 97554 580 42523186
Lymphocytic infiltration 22.29 10.92 18 97551 928 42522838
Heart rate irregular 22.21 10.92 84 97485 15966 42507800
Malignant melanoma 22.03 10.92 59 97510 9341 42514425
Complications of transplanted lung 21.71 10.92 12 97557 325 42523441
Laparotomy 21.71 10.92 12 97557 325 42523441
Proctitis ulcerative 21.69 10.92 10 97559 182 42523584
Restlessness 21.62 10.92 21 97548 29228 42494538
Nephropathy toxic 21.57 10.92 86 97483 16752 42507014
Postoperative abscess 21.53 10.92 13 97556 417 42523349
Intestinal mass 21.49 10.92 15 97554 619 42523147
B-lymphocyte count decreased 21.46 10.92 17 97552 852 42522914
Acute respiratory failure 21.32 10.92 35 97534 38823 42484943
Cutaneous malacoplakia 21.09 10.92 9 97560 135 42523631
Eccrine carcinoma 21.09 10.92 6 97563 23 42523743
Narcotic bowel syndrome 21.03 10.92 9 97560 136 42523630
Hallucination, visual 20.89 10.92 11 97558 21009 42502757
Haematemesis 20.83 10.92 23 97546 30176 42493590
Strongyloidiasis 20.81 10.92 32 97537 3399 42520367
Anal cancer 20.60 10.92 13 97556 452 42523314
Congenital oesophageal anomaly 20.58 10.92 8 97561 93 42523673
Small intestinal resection 20.56 10.92 15 97554 664 42523102
Antisynthetase syndrome 20.51 10.92 9 97560 145 42523621
Cutaneous nocardiosis 20.48 10.92 10 97559 208 42523558
Aspartate aminotransferase increased 20.35 10.92 99 97470 77064 42446702
Obstruction 20.33 10.92 30 97539 3073 42520693
Laryngeal mass 20.15 10.92 6 97563 28 42523738
Intentional self-injury 20.10 10.92 5 97564 15197 42508569
Congenital cystic lung 19.93 10.92 10 97559 221 42523545
Enterovesical fistula 19.92 10.92 17 97552 947 42522819
Hyperphosphataemia 19.89 10.92 3 97566 13001 42510765
Aspiration 19.89 10.92 8 97561 17878 42505888
Swollen tongue 19.82 10.92 12 97557 21219 42502547
Prostatic specific antigen increased 19.77 10.92 7 97562 16918 42506848
Intestinal diaphragm disease 19.76 10.92 11 97558 302 42523464
Arteriosclerosis coronary artery 19.76 10.92 90 97479 18587 42505179
Skin papilloma 19.74 10.92 28 97541 2766 42521000
Papilloma viral infection 19.74 10.92 15 97554 707 42523059
Varicella 19.72 10.92 24 97545 2041 42521725
Herpes simplex hepatitis 19.61 10.92 9 97560 162 42523604
Listeria encephalitis 19.60 10.92 7 97562 63 42523703
Epstein-Barr virus infection reactivation 19.56 10.92 27 97542 2600 42521166
Prostate cancer 19.49 10.92 46 97523 44597 42479169
Herpes simplex test positive 19.45 10.92 10 97559 233 42523533
Hallucination, auditory 19.44 10.92 5 97564 14859 42508907
Rectal haemorrhage 19.36 10.92 186 97383 49420 42474346
Herpes zoster meningoencephalitis 19.34 10.92 13 97556 504 42523262
Skin cancer 19.31 10.92 64 97505 11398 42512368
Gastroenteritis clostridial 19.31 10.92 12 97557 406 42523360
Graft versus host disease in lung 19.27 10.92 15 97554 733 42523033
Subcutaneous abscess 19.19 10.92 36 97533 4492 42519274
Lung abscess 19.18 10.92 30 97539 3233 42520533
Neutrophilic dermatosis 19.13 10.92 11 97558 322 42523444
Oesophageal atresia 19.07 10.92 13 97556 516 42523250
Mycobacterium abscessus infection 19.06 10.92 15 97554 745 42523021
Pneumonitis 19.01 10.92 42 97527 41676 42482090
Dementia 18.94 10.92 7 97562 16473 42507293
Osteosarcoma recurrent 18.93 10.92 8 97561 117 42523649
Peritoneal abscess 18.93 10.92 8 97561 117 42523649
Chromoblastomycosis 18.93 10.92 8 97561 117 42523649
Blood phosphorus increased 18.90 10.92 3 97566 12522 42511244
Aplasia pure red cell 18.88 10.92 47 97522 7119 42516647
Therapy interrupted 18.86 10.92 14 97555 22236 42501530
Cytomegalovirus duodenitis 18.86 10.92 7 97562 71 42523695
Paracoccidioides infection 18.86 10.92 7 97562 71 42523695
Ischaemic stroke 18.83 10.92 14 97555 22219 42501547
Erythropoiesis abnormal 18.82 10.92 11 97558 332 42523434
Mucous stools 18.76 10.92 26 97543 2514 42521252
Autoscopy 18.67 10.92 10 97559 254 42523512
Oedema 18.65 10.92 59 97510 51942 42471824
Vision blurred 18.51 10.92 62 97507 53637 42470129
Therapy cessation 18.49 10.92 12 97557 20438 42503328
Hepatosplenomegaly 18.46 10.92 36 97533 4624 42519142
Cutaneous leishmaniasis 18.46 10.92 10 97559 260 42523506
American trypanosomiasis 18.44 10.92 11 97558 345 42523421
Anaphylactic shock 18.43 10.92 16 97553 23501 42500265
Osteomyelitis chronic 18.42 10.92 11 97558 346 42523420
Sebaceous adenoma 18.36 10.92 6 97563 40 42523726
Serum sickness 18.30 10.92 24 97545 2201 42521565
Dysarthria 18.21 10.92 40 97529 39767 42483999
Hiccups 18.18 10.92 3 97566 12168 42511598
Oropharyngeal squamous cell carcinoma 18.15 10.92 10 97559 269 42523497
Orchitis 18.08 10.92 24 97545 2227 42521539
Central nervous system lesion 18.05 10.92 49 97520 7821 42515945
Small intestinal ulcer haemorrhage 18.04 10.92 7 97562 81 42523685
Muscle rigidity 17.95 10.92 3 97566 12056 42511710
Hodgkin's disease 17.93 10.92 15 97554 813 42522953
Upper gastrointestinal haemorrhage 17.86 10.92 26 97543 30273 42493493
Intestinal adenocarcinoma 17.81 10.92 7 97562 84 42523682
Hepatitis B 17.67 10.92 44 97525 6667 42517099
Mastoidectomy 17.56 10.92 4 97565 4 42523762
Anastomotic ulcer 17.54 10.92 12 97557 479 42523287
Poor venous access 17.49 10.92 46 97523 7206 42516560
Osteonecrosis of jaw 17.46 10.92 11 97558 19038 42504728
Drain placement 17.45 10.92 7 97562 89 42523677
Odynophagia 17.42 10.92 44 97525 6726 42517040
Pseudomonas aeruginosa meningitis 17.31 10.92 6 97563 49 42523717
Therapy partial responder 17.26 10.92 91 97478 19930 42503836
Testicular cancer metastatic 17.24 10.92 7 97562 92 42523674
Hypocalvaria 17.20 10.92 6 97563 50 42523716
Proctalgia 17.11 10.92 45 97524 7048 42516718
Antiphospholipid syndrome 17.08 10.92 13 97556 614 42523152
Pseudopolyp 17.08 10.92 10 97559 303 42523463
Blood potassium decreased 17.06 10.92 13 97556 20371 42503395
Arthritis 17.05 10.92 159 97410 41906 42481860
Infected fistula 17.04 10.92 9 97560 222 42523544
Thymoma 17.04 10.92 8 97561 152 42523614
Appendicectomy 16.99 10.92 19 97550 1476 42522290
Device issue 16.82 10.92 5 97564 13504 42510262
Cryptococcosis 16.80 10.92 28 97541 3183 42520583
Anastomotic stenosis 16.75 10.92 11 97558 410 42523356
Laser therapy 16.68 10.92 4 97565 6 42523760
Cytomegalovirus test positive 16.66 10.92 33 97536 4286 42519480
Liver disorder 16.65 10.92 151 97418 39493 42484273
Chorioretinopathy 16.62 10.92 19 97550 1512 42522254
Glucose tolerance impaired 16.51 10.92 32 97537 4092 42519674
Chondropathy 16.50 10.92 17 97552 1203 42522563
Central nervous system lymphoma 16.43 10.92 18 97551 1367 42522399
Oesophagopleural fistula 16.42 10.92 6 97563 58 42523708
Meningitis cryptococcal 16.34 10.92 28 97541 3255 42520511
Papilloedema 16.33 10.92 28 97541 3258 42520508
Carotid artery perforation 16.30 10.92 4 97565 7 42523759
Campylobacter gastroenteritis 16.29 10.92 16 97553 1069 42522697
Activated partial thromboplastin time prolonged 16.29 10.92 8 97561 15895 42507871
Rectal perforation 16.28 10.92 12 97557 540 42523226
Enterocolitis haemorrhagic 16.22 10.92 16 97553 1075 42522691
Brain stem syndrome 16.20 10.92 13 97556 664 42523102
Pulmonary amyloidosis 16.19 10.92 5 97564 27 42523739
Tuberculosis gastrointestinal 16.17 10.92 9 97560 247 42523519
Psoriatic arthropathy 16.16 10.92 20 97549 24947 42498819
Underdose 16.16 10.92 9 97560 16657 42507109
Lip swelling 16.14 10.92 12 97557 19041 42504725
Neuralgia 16.13 10.92 21 97548 25626 42498140
Tremor 16.10 10.92 143 97426 96786 42426980
Paranoia 16.05 10.92 6 97563 14020 42509746
Posterior reversible encephalopathy syndrome 16.04 10.92 65 97504 12756 42511010
Anastomotic complication 15.99 10.92 11 97558 443 42523323
Fungal skin infection 15.99 10.92 28 97541 3313 42520453
Blood sodium decreased 15.96 10.92 11 97558 18151 42505615
Palpitations 15.95 10.92 61 97508 50736 42473030
Inappropriate antidiuretic hormone secretion 15.94 10.92 9 97560 16532 42507234
Tinnitus 15.94 10.92 26 97543 28912 42494854
Diarrhoea 15.91 10.92 878 96691 459971 42063795
Ileocolostomy 15.89 10.92 5 97564 29 42523737
Anger 15.88 10.92 5 97564 13013 42510753
Rectal cancer 15.87 10.92 23 97546 2317 42521449
Relapsing fever 15.85 10.92 8 97561 179 42523587
Autoimmune neutropenia 15.84 10.92 10 97559 348 42523418
Skin laceration 15.82 10.92 69 97500 13989 42509777
Graft versus host disease 15.75 10.92 65 97504 12860 42510906
Back pain 15.74 10.92 229 97340 141547 42382219
Sacroiliitis 15.72 10.92 21 97548 1961 42521805
Glycosylated haemoglobin increased 15.70 10.92 5 97564 12919 42510847
Mucocutaneous leishmaniasis 15.67 10.92 7 97562 118 42523648
Dysphagia 15.53 10.92 100 97469 72619 42451147
Hypophosphataemia 15.52 10.92 15 97554 20930 42502836
Thrombocytosis 15.52 10.92 34 97535 4741 42519025
Cytomegalovirus syndrome 15.51 10.92 7 97562 121 42523645
Myoclonus 15.44 10.92 10 97559 17055 42506711
B-cell lymphoma stage IV 15.42 10.92 6 97563 70 42523696
Infectious mononucleosis 15.36 10.92 13 97556 716 42523050
Injection site swelling 15.29 10.92 10 97559 16963 42506803
Disseminated cytomegaloviral infection 15.27 10.92 9 97560 276 42523490
Sarcoidosis 15.26 10.92 29 97540 3653 42520113
Aqueductal stenosis 15.25 10.92 3 97566 0 42523766
Pulmonary granuloma 15.23 10.92 19 97550 1658 42522108
Peripheral T-cell lymphoma unspecified stage IV 15.22 10.92 5 97564 34 42523732
Sensory processing disorder 15.22 10.92 5 97564 34 42523732
Systemic candida 15.20 10.92 36 97533 5283 42518483
Diffuse large B-cell lymphoma stage III 15.19 10.92 6 97563 73 42523693
Gastroenteritis bacterial 15.12 10.92 6 97563 74 42523692
Fluid retention 15.10 10.92 31 97538 31588 42492178
Diaphragmatic injury 15.10 10.92 7 97562 129 42523637
Neonatal respiratory failure 15.10 10.92 10 97559 378 42523388
Primary mediastinal large B-cell lymphoma stage IV 15.07 10.92 4 97565 11 42523755
Erectile dysfunction 15.06 10.92 21 97548 24892 42498874
Parkinsonism 15.04 10.92 3 97566 10620 42513146
Tracheitis 15.00 10.92 15 97554 1024 42522742
Arrhythmia 14.98 10.92 45 97524 40272 42483494
Cutaneous T-cell lymphoma stage III 14.97 10.92 5 97564 36 42523730
Pneumonia legionella 14.96 10.92 22 97547 2246 42521520
Episcleritis 14.94 10.92 8 97561 203 42523563
Splenic embolism 14.87 10.92 9 97560 290 42523476
Loss of personal independence in daily activities 14.87 10.92 177 97392 49639 42474127
Drug specific antibody absent 14.77 10.92 6 97563 79 42523687
Viral infection 14.71 10.92 95 97474 22388 42501378
Spondyloarthropathy 14.70 10.92 14 97555 900 42522866
Coloboma 14.67 10.92 7 97562 138 42523628
Acne 14.62 10.92 66 97503 13578 42510188
Large intestine infection 14.61 10.92 21 97548 2100 42521666
Kidney fibrosis 14.60 10.92 24 97545 2698 42521068
Hemivertebra 14.58 10.92 7 97562 140 42523626
Leukopenia neonatal 14.57 10.92 4 97565 13 42523753
New onset diabetes after transplantation 14.53 10.92 8 97561 215 42523551
Lymph node tuberculosis 14.52 10.92 11 97558 516 42523250
Biopsy skin abnormal 14.50 10.92 6 97563 83 42523683
Colonoscopy abnormal 14.50 10.92 6 97563 83 42523683
Brain abscess 14.49 10.92 31 97538 4253 42519513
Epstein-Barr virus antibody positive 14.44 10.92 9 97560 306 42523460
Alanine aminotransferase increased 14.43 10.92 131 97438 88275 42435491
Ureteric dilatation 14.43 10.92 8 97561 218 42523548
Meningioma malignant 14.41 10.92 5 97564 41 42523725
Device leakage 14.37 10.92 3 97566 10282 42513484
Herpes simplex colitis 14.34 10.92 4 97565 14 42523752
Meconium peritonitis 14.34 10.92 4 97565 14 42523752
Injury 14.32 10.92 18 97551 22298 42501468
Withdrawal syndrome 14.29 10.92 8 97561 14767 42508999
Skin ulcer 14.27 10.92 104 97465 25497 42498269
Atelectasis 14.19 10.92 14 97555 19347 42504419
Panniculitis 14.16 10.92 21 97548 2160 42521606
Subperiosteal abscess 14.06 10.92 6 97563 90 42523676
Neonatal hyponatraemia 14.06 10.92 6 97563 90 42523676
Liver function test increased 14.01 10.92 86 97483 19912 42503854
Testicular abscess 14.00 10.92 6 97563 91 42523675
Tonsillitis bacterial 14.00 10.92 5 97564 45 42523721
Short-bowel syndrome 13.98 10.92 9 97560 324 42523442
Sinus tachycardia 13.95 10.92 16 97553 20637 42503129
Drug effective for unapproved indication 13.93 10.92 40 97529 6593 42517173
Pulmonary paracoccidioidomycosis 13.93 10.92 4 97565 16 42523750
Antibody test abnormal 13.86 10.92 9 97560 329 42523437
Dystonia 13.77 10.92 6 97563 12784 42510982
Micturition urgency 13.76 10.92 5 97564 11893 42511873
Product administration error 13.75 10.92 13 97556 18330 42505436
Blood bilirubin increased 13.74 10.92 50 97519 42202 42481564
Granulomatous liver disease 13.72 10.92 12 97557 691 42523075
Enterostomy 13.60 10.92 6 97563 98 42523668
Weight fluctuation 13.60 10.92 37 97532 5914 42517852
Hypomagnesaemia 13.55 10.92 28 97541 28460 42495306
Cytomegalovirus oesophagitis 13.50 10.92 11 97558 574 42523192
Polyarteritis nodosa 13.48 10.92 9 97560 345 42523421
Gastrointestinal ulcer 13.44 10.92 19 97550 1871 42521895
Hepatitis G 13.37 10.92 4 97565 19 42523747
Microscopic polyangiitis 13.35 10.92 8 97561 253 42523513
Generalised tonic-clonic seizure 13.35 10.92 25 97544 26354 42497412
Ventricular extrasystoles 13.32 10.92 7 97562 13383 42510383
Exposure to SARS-CoV-2 13.29 10.92 11 97558 587 42523179
Mood altered 13.28 10.92 4 97565 10714 42513052
Injection site erythema 13.26 10.92 16 97553 20179 42503587
Ageusia 13.22 10.92 5 97564 11600 42512166
Peritoneal candidiasis 13.21 10.92 4 97565 20 42523746
Atrial flutter 13.20 10.92 12 97557 17239 42506527
Sideroblastic anaemia 13.18 10.92 9 97560 358 42523408
Precursor T-lymphoblastic lymphoma/leukaemia stage I 13.17 10.92 3 97566 3 42523763
Hepatobiliary cancer 13.17 10.92 3 97566 3 42523763
Appendiceal abscess 13.12 10.92 6 97563 107 42523659
Haemorrhage intracranial 13.11 10.92 12 97557 17180 42506586
Blood pressure decreased 13.08 10.92 79 97490 58253 42465513
Mycoplasma test positive 13.07 10.92 6 97563 108 42523658
Stoma creation 13.07 10.92 6 97563 108 42523658
Pyrexia 13.05 10.92 1059 96510 392983 42130783
Magnetic resonance imaging head abnormal 13.04 10.92 17 97552 1550 42522216
Acarodermatitis 13.01 10.92 12 97557 741 42523025
Vertigo 13.01 10.92 38 97531 34309 42489457
Anaphylactic reaction 12.99 10.92 52 97517 42691 42481075
Pneumonia cytomegaloviral 12.98 10.92 29 97540 4097 42519669
Infective scleritis 12.95 10.92 5 97564 57 42523709
Device malfunction 12.93 10.92 6 97563 12321 42511445
Angina unstable 12.93 10.92 5 97564 11443 42512323
External auditory canal atresia 12.85 10.92 7 97562 184 42523582
Gastrointestinal scarring 12.85 10.92 7 97562 184 42523582
Listeriosis 12.83 10.92 16 97553 1395 42522371
Graft loss 12.83 10.92 13 97556 902 42522864
Autoimmune hepatitis 12.80 10.92 35 97534 5610 42518156
Hypersensitivity vasculitis 12.77 10.92 25 97544 3219 42520547
Akathisia 12.77 10.92 4 97565 10447 42513319
Vitamin B1 decreased 12.75 10.92 9 97560 378 42523388
Skin lesion 12.71 10.92 106 97463 27068 42496698
Dysphonia 12.67 10.92 29 97540 28421 42495345
Hyperleukocytosis 12.67 10.92 22 97547 2586 42521180
Job dissatisfaction 12.65 10.92 7 97562 190 42523576
Diabetes mellitus inadequate control 12.64 10.92 10 97559 15380 42508386
Opportunistic infection 12.61 10.92 19 97550 1982 42521784
Pollakiuria 12.60 10.92 20 97549 22485 42501281
Extremity contracture 12.60 10.92 12 97557 772 42522994
Polychondritis 12.59 10.92 9 97560 386 42523380
Subdural haematoma 12.55 10.92 21 97548 23117 42500649
Breath sounds abnormal 12.51 10.92 6 97563 12087 42511679
Steroid diabetes 12.49 10.92 23 97546 2829 42520937
Toxic skin eruption 12.49 10.92 8 97561 13722 42510044
Acute pulmonary histoplasmosis 12.48 10.92 7 97562 195 42523571
Prescribed underdose 12.45 10.92 4 97565 10278 42513488
Investigation abnormal 12.44 10.92 11 97558 643 42523123
Gastric fistula 12.41 10.92 6 97563 122 42523644
Shoulder operation 12.39 10.92 16 97553 1445 42522321
Salmonellosis 12.26 10.92 15 97554 1283 42522483
Tumour lysis syndrome 12.22 10.92 20 97549 22211 42501555
Drug withdrawal syndrome 12.21 10.92 19 97550 21530 42502236
Fluctuance 12.20 10.92 4 97565 27 42523739
Pancreatitis acute 12.20 10.92 124 97445 33440 42490326
Hyperthyroidism 12.19 10.92 9 97560 14332 42509434
Respiratory tract infection fungal 12.15 10.92 12 97557 807 42522959
Biopsy kidney abnormal 12.15 10.92 6 97563 128 42523638
Haematoma 12.13 10.92 29 97540 27994 42495772
Progressive bulbar palsy 12.07 10.92 4 97565 28 42523738
Multiple sclerosis relapse 12.06 10.92 9 97560 14255 42509511
Psychomotor hyperactivity 12.02 10.92 5 97564 10953 42512813
Injection site hypersensitivity 12.01 10.92 9 97560 415 42523351
Asthma 12.01 10.92 205 97364 62109 42461657
Hypernatraemia 11.98 10.92 4 97565 10028 42513738
Anaplastic large cell lymphoma T- and null-cell types stage III 11.96 10.92 3 97566 6 42523760
Uveal melanoma 11.96 10.92 3 97566 6 42523760
Actinic cheilitis 11.96 10.92 3 97566 6 42523760
Spermatozoa progressive motility decreased 11.96 10.92 7 97562 212 42523554
Polyuria 11.94 10.92 4 97565 10007 42513759
Osteosarcoma 11.90 10.92 8 97561 310 42523456
Electrolyte imbalance 11.82 10.92 13 97556 17088 42506678
Renal failure 11.82 10.92 245 97324 143481 42380285
Penicillium infection 11.77 10.92 8 97561 316 42523450
Rectal discharge 11.75 10.92 8 97561 317 42523449
Haemoglobin decreased 11.74 10.92 223 97346 132248 42391518
Focal segmental glomerulosclerosis 11.74 10.92 21 97548 2527 42521239
Leiomyosarcoma metastatic 11.65 10.92 3 97566 7 42523759
Atypical mycobacterial infection 11.65 10.92 15 97554 1351 42522415
Hyperplasia 11.65 10.92 11 97558 700 42523066
Bone pain 11.64 10.92 23 97546 23769 42499997
C-reactive protein abnormal 11.62 10.92 47 97522 9214 42514552
Cutaneous T-cell lymphoma refractory 11.61 10.92 4 97565 32 42523734
Overgrowth bacterial 11.51 10.92 6 97563 144 42523622
IgA nephropathy 11.50 10.92 20 97549 2354 42521412
Placental disorder 11.48 10.92 5 97564 79 42523687
Blister 11.47 10.92 29 97540 27461 42496305
Cerebral haemorrhage 11.47 10.92 48 97521 38918 42484848
Bile duct stenosis 11.46 10.92 15 97554 1373 42522393
Blood pressure increased 11.44 10.92 310 97259 101618 42422148
Anaplastic large cell lymphoma T- and null-cell types 11.43 10.92 6 97563 146 42523620
Chest discomfort 11.39 10.92 92 97477 63524 42460242
Cheilitis 11.38 10.92 21 97548 2587 42521179
Oxygen saturation decreased 11.38 10.92 94 97475 64593 42459173
Pseudopolyposis 11.37 10.92 5 97564 81 42523685
Viral test positive 11.28 10.92 7 97562 236 42523530
Schizophrenia 11.28 10.92 5 97564 10545 42513221
Mania 11.27 10.92 5 97564 10542 42513224
Arthritis enteropathic 11.25 10.92 6 97563 151 42523615
Hyperlipidaemia 11.23 10.92 20 97549 21496 42502270
Chromaturia 11.22 10.92 12 97557 15977 42507789
Blood urea increased 11.21 10.92 38 97531 32755 42491011
Decubitus ulcer 11.15 10.92 5 97564 10472 42513294
Acute pulmonary oedema 11.14 10.92 3 97566 8648 42515118
Intestinal mucosal hypertrophy 11.11 10.92 6 97563 155 42523611
Sudden death 11.10 10.92 13 97556 16616 42507150
Colectomy total 11.05 10.92 8 97561 350 42523416
Cardiac myxoma 11.01 10.92 4 97565 38 42523728
Procedural intestinal perforation 11.01 10.92 4 97565 38 42523728
Gastrointestinal cancer metastatic 11.00 10.92 5 97564 88 42523678
Dysplasia 10.99 10.92 13 97556 1073 42522693
Death neonatal 10.97 10.92 8 97561 354 42523412

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Off label use 1222.71 10.04 7888 308734 1492297 108780380
Treatment failure 725.99 10.04 2086 314536 275148 109997529
Drug ineffective 689.82 10.04 7001 309621 1513539 108759138
Death 659.86 10.04 618 316004 698251 109574426
Completed suicide 626.03 10.04 14 316608 242367 110030310
Condition aggravated 582.22 10.04 3845 312777 730991 109541686
Colitis ulcerative 575.62 10.04 894 315728 76469 110196208
Intentional product use issue 524.53 10.04 1732 314890 246174 110026503
Exposure during pregnancy 507.78 10.04 1330 315292 166094 110106583
Post transplant lymphoproliferative disorder 504.03 10.04 392 316230 15221 110257456
Toxicity to various agents 458.94 10.04 420 316202 480135 109792542
Febrile neutropenia 430.24 10.04 184 316438 316583 109956094
Drug abuse 426.88 10.04 19 316603 177392 110095285
Maternal exposure during pregnancy 414.20 10.04 1634 314988 253249 110019428
Hypotension 412.72 10.04 537 316085 523312 109749365
Malignant neoplasm progression 361.65 10.04 39 316583 174528 110098149
Intestinal stenosis 360.80 10.04 203 316419 4512 110268165
Acute kidney injury 345.81 10.04 822 315800 634608 109638069
Drug intolerance 339.24 10.04 2157 314465 404355 109868322
Somnolence 338.56 10.04 217 316405 297232 109975445
Fall 333.69 10.04 774 315848 602708 109669969
Cytomegalovirus infection 331.71 10.04 575 316047 53869 110218808
Hyponatraemia 331.59 10.04 105 316517 217548 110055129
Therapeutic product effect incomplete 321.11 10.04 1381 315241 222424 110050253
C-reactive protein increased 319.07 10.04 1353 315269 216566 110056111
Premature delivery 317.92 10.04 415 316207 30217 110242460
Disease recurrence 316.95 10.04 600 316022 60184 110212493
Fistula 313.47 10.04 296 316326 15003 110257674
Drug level below therapeutic 313.07 10.04 263 316359 11410 110261267
Therapeutic product effect decreased 311.79 10.04 1456 315166 242860 110029817
Hepatosplenic T-cell lymphoma 297.13 10.04 111 316511 896 110271781
Atrial fibrillation 287.70 10.04 149 316473 229493 110043184
Onychomadesis 284.39 10.04 487 316135 45176 110227501
Anal fistula 282.79 10.04 217 316405 8256 110264421
Bone erosion 280.22 10.04 488 316134 45883 110226794
Inflammation 279.16 10.04 1195 315427 192043 110080634
Epstein-Barr virus infection 278.80 10.04 305 316317 18433 110254244
Cushingoid 260.07 10.04 237 316385 11475 110261202
Faecal calprotectin increased 257.57 10.04 187 316435 6532 110266145
Liver function test increased 254.69 10.04 690 315932 87858 110184819
Ileal stenosis 242.69 10.04 138 316484 3132 110269545
Anal abscess 241.94 10.04 227 316395 11411 110261266
Onychomycosis 241.34 10.04 412 316210 38119 110234558
Constipation 240.45 10.04 409 316213 357377 109915300
Intentional overdose 238.60 10.04 45 316577 132456 110140221
Product label confusion 238.09 10.04 309 316313 22368 110250309
Product dose omission issue 234.02 10.04 349 316273 321433 109951244
Syncope 228.69 10.04 149 316473 202387 110070290
Diffuse large B-cell lymphoma 224.84 10.04 252 316370 15646 110257031
Cardiac failure congestive 222.67 10.04 77 316545 150923 110121754
Lupus-like syndrome 221.80 10.04 410 316212 40382 110232295
Bradycardia 218.05 10.04 86 316536 155431 110117246
Nodular regenerative hyperplasia 217.24 10.04 102 316520 1529 110271148
Grip strength decreased 215.97 10.04 610 316012 79564 110193113
Neutrophil count decreased 213.71 10.04 43 316579 120898 110151779
Red blood cell sedimentation rate increased 210.18 10.04 595 316027 77707 110194970
Back injury 209.90 10.04 437 316185 46962 110225715
Hepatitis 207.26 10.04 648 315974 89406 110183271
Live birth 204.39 10.04 546 316076 68938 110203739
Transplant rejection 204.12 10.04 299 316323 24268 110248409
Drug specific antibody present 203.76 10.04 179 316443 8255 110264422
Drug ineffective for unapproved indication 203.53 10.04 703 315919 102135 110170542
Vasculitis 203.19 10.04 367 316255 35506 110237171
Hypokalaemia 200.90 10.04 138 316484 182310 110090367
Drug level decreased 199.84 10.04 256 316366 18292 110254385
Product use issue 197.73 10.04 1548 315074 310147 109962530
Cardio-respiratory arrest 196.89 10.04 45 316577 115791 110156886
Dehydration 194.75 10.04 312 316310 279199 109993478
Dyspnoea 192.10 10.04 2136 314486 1104736 109167941
Basal cell carcinoma 191.90 10.04 410 316212 44860 110227817
Cardiac arrest 189.89 10.04 170 316452 196583 110076094
Lymphoproliferative disorder 188.17 10.04 160 316462 7058 110265619
Platelet count decreased 185.58 10.04 232 316390 230211 110042466
Cerebrovascular accident 185.54 10.04 148 316474 181136 110091541
Finger deformity 185.46 10.04 337 316285 32755 110239922
Cytomegalovirus colitis 185.06 10.04 157 316465 6904 110265773
Eosinophilic granulomatosis with polyangiitis 183.97 10.04 188 316434 10498 110262179
Coma 181.01 10.04 56 316566 117813 110154864
Epstein-Barr virus associated lymphoproliferative disorder 175.83 10.04 130 316492 4672 110268005
Loss of consciousness 175.05 10.04 182 316440 196124 110076553
Pneumocystis jirovecii pneumonia 171.97 10.04 379 316243 42356 110230321
Anaemia 171.71 10.04 894 315728 546192 109726485
Synovitis 171.46 10.04 1357 315265 272735 109999942
Seizure 170.57 10.04 230 316392 220955 110051722
Product use in unapproved indication 169.35 10.04 1992 314630 445385 109827292
Electrocardiogram QT prolonged 168.70 10.04 51 316571 108909 110163768
Anal fissure 168.59 10.04 173 316449 9708 110262969
Lupus nephritis 168.40 10.04 125 316497 4520 110268157
Haemophagocytic lymphohistiocytosis 167.57 10.04 314 316308 31245 110241432
Adverse reaction 166.64 10.04 302 316320 29292 110243385
Abscess 164.54 10.04 288 316334 27181 110245496
Drug eruption 163.25 10.04 427 316195 53232 110219445
Sedation 162.68 10.04 9 316613 69674 110203003
SLE arthritis 161.99 10.04 63 316559 574 110272103
Hypercholesterolaemia 161.00 10.04 599 316023 90238 110182439
Myocardial infarction 160.36 10.04 188 316434 191895 110080782
Disseminated tuberculosis 159.17 10.04 126 316496 5020 110267657
Frequent bowel movements 159.04 10.04 508 316114 70882 110201795
Rheumatoid arthritis 158.62 10.04 1429 315193 298184 109974493
Normal newborn 157.18 10.04 249 316373 21647 110251030
Kidney transplant rejection 155.98 10.04 182 316440 11805 110260872
Large intestinal stenosis 155.91 10.04 110 316512 3670 110269007
Chronic obstructive pulmonary disease 155.26 10.04 59 316563 109099 110163578
Fatigue 154.73 10.04 2501 314121 1213457 109059220
Hyperhidrosis 154.56 10.04 185 316437 187113 110085564
Depressed level of consciousness 154.27 10.04 64 316558 112214 110160463
Nail disorder 153.29 10.04 438 316184 57497 110215180
Arthritis 153.20 10.04 911 315711 166675 110106002
C-reactive protein abnormal 153.05 10.04 756 315866 128939 110143738
Cholestasis of pregnancy 152.90 10.04 74 316548 1191 110271486
Retinitis 151.35 10.04 305 316317 32022 110240655
Progressive multifocal leukoencephalopathy 151.24 10.04 263 316359 24693 110247984
Hypoglycaemia 150.38 10.04 72 316550 116032 110156645
Osteoporosis 149.73 10.04 569 316053 86583 110186094
Injection site pain 148.67 10.04 174 316448 177748 110094929
Pulmonary vasculitis 146.15 10.04 133 316489 6427 110266250
Pulmonary fibrosis 145.69 10.04 629 315993 101413 110171264
Coeliac disease 145.26 10.04 357 316265 42830 110229847
Ileocaecal resection 145.17 10.04 57 316565 534 110272143
Erythema nodosum 142.60 10.04 132 316490 6521 110266156
Suicide attempt 141.95 10.04 59 316563 103335 110169342
Tremor 140.58 10.04 226 316396 202006 110070671
Therapeutic response decreased 140.20 10.04 598 316024 95901 110176776
Blood glucose increased 139.59 10.04 105 316517 132391 110140286
Blood cholesterol increased 138.98 10.04 956 315666 183829 110088848
Back pain 138.40 10.04 569 316053 370427 109902250
Drug tolerance decreased 137.57 10.04 267 316355 27273 110245404
Lactic acidosis 137.38 10.04 47 316575 92764 110179913
Musculoskeletal stiffness 137.22 10.04 1313 315309 278509 109994168
Neutropenia 136.99 10.04 579 316043 374041 109898636
Neuropathy peripheral 136.62 10.04 188 316434 179089 110093588
Breast cancer stage III 136.29 10.04 517 316105 78600 110194077
Joint dislocation 136.19 10.04 302 316320 33888 110238789
Hepatic cirrhosis 136.15 10.04 465 316157 67161 110205516
Contraindicated product administered 135.95 10.04 1193 315429 247074 110025603
Intentional product misuse 135.36 10.04 109 316513 132795 110139882
Systemic lupus erythematosus 134.55 10.04 1213 315409 253125 110019552
Wrong technique in product usage process 133.22 10.04 42 316580 87306 110185371
Hallucination 132.75 10.04 62 316560 101370 110171307
Rheumatic fever 132.38 10.04 697 315925 121882 110150795
Inappropriate schedule of product administration 131.61 10.04 1016 315606 202621 110070056
Exostosis 131 10.04 357 316265 45599 110227078
Orthostatic hypotension 129.33 10.04 18 316604 66231 110206446
Agitation 129.18 10.04 82 316540 112969 110159708
Intestinal resection 127.57 10.04 99 316523 3830 110268847
Drug-induced liver injury 127.12 10.04 679 315943 119388 110153289
Coombs positive haemolytic anaemia 126.40 10.04 70 316552 1507 110271170
Ileostomy 125.96 10.04 81 316541 2311 110270366
Serotonin syndrome 125.63 10.04 12 316610 59141 110213536
Cardiac failure 125.47 10.04 215 316407 187411 110085266
JC virus infection 125.25 10.04 111 316511 5179 110267498
Pre-eclampsia 123.84 10.04 138 316484 8512 110264165
Foot deformity 122.94 10.04 361 316261 48119 110224558
Balance disorder 121.98 10.04 93 316529 116467 110156210
Rheumatoid nodule 121.83 10.04 213 316409 20083 110252594
Gastrointestinal haemorrhage 121.73 10.04 178 316444 165340 110107337
Hyperkalaemia 120.93 10.04 126 316496 135670 110137007
Arthralgia 119.15 10.04 2997 313625 776635 109496042
Colectomy 118.14 10.04 99 316523 4279 110268398
Neuritis 118.09 10.04 125 316497 7274 110265403
White blood cell count decreased 118.02 10.04 305 316317 229085 110043592
Clear cell renal cell carcinoma 117.87 10.04 82 316540 2674 110270003
Squamous cell carcinoma 117.70 10.04 199 316423 18264 110254413
Nocardiosis 116.87 10.04 125 316497 7361 110265316
Mucosal inflammation 115.07 10.04 66 316556 96075 110176602
Hepatic enzyme increased 114.38 10.04 1413 315209 319479 109953198
Suicidal ideation 113.13 10.04 64 316558 93873 110178804
Lung disorder 112.85 10.04 892 315730 179155 110093522
Night sweats 112.75 10.04 713 315909 133270 110139407
Rebound effect 112.72 10.04 173 316449 14633 110258044
Diarrhoea haemorrhagic 112.47 10.04 178 316444 15461 110257216
Gastrointestinal disorder 112.09 10.04 1122 315500 240830 110031847
Intestinal obstruction 111.56 10.04 371 316251 52856 110219821
Cytomegalovirus viraemia 111.30 10.04 190 316432 17574 110255103
Urinary retention 110.83 10.04 31 316591 69652 110203025
Bursitis 110.34 10.04 693 315929 129225 110143452
Arthropathy 110.33 10.04 1284 315338 286238 109986439
Intestinal fistula 109.77 10.04 66 316556 1667 110271010
Epstein-Barr virus associated lymphoma 109.42 10.04 65 316557 1605 110271072
Lung transplant rejection 108.19 10.04 68 316554 1863 110270814
Injection site erythema 108.02 10.04 68 316554 94108 110178569
Drug interaction 107.61 10.04 915 315707 499268 109773409
Panniculitis 107.46 10.04 174 316448 15408 110257269
Elbow deformity 107.44 10.04 62 316560 1448 110271229
Wound infection 107.25 10.04 553 316069 95912 110176765
Respiratory arrest 106.66 10.04 19 316603 58280 110214397
Infusion related reaction 106.25 10.04 1606 315016 379556 109893121
Total lung capacity abnormal 106.20 10.04 95 316527 4488 110268189
Plasmablastic lymphoma 105.87 10.04 50 316572 760 110271917
Pneumonia aspiration 105.77 10.04 50 316572 81183 110191494
Blood iron abnormal 105.01 10.04 61 316561 1443 110271234
Demyelination 104.51 10.04 132 316490 9297 110263380
Small intestinal stenosis 104.47 10.04 58 316564 1255 110271422
Joint stiffness 104.16 10.04 425 316197 66818 110205859
Scleritis 103.72 10.04 101 316521 5319 110267358
Nausea 103.33 10.04 2722 313900 1232968 109039709
Injection site swelling 103.03 10.04 25 316597 61765 110210912
Pulmonary tuberculosis 102.99 10.04 129 316493 9010 110263667
Histoplasmosis disseminated 102.81 10.04 87 316535 3812 110268865
Thrombocytopenia 102.78 10.04 582 316040 348303 109924374
Premature labour 102.62 10.04 129 316493 9043 110263634
Unresponsive to stimuli 102.16 10.04 28 316594 63762 110208915
Anti-cyclic citrullinated peptide antibody positive 101.93 10.04 879 315743 181105 110091572
Blepharospasm 101.64 10.04 367 316255 54484 110218193
Dizziness 101.63 10.04 1398 315224 696795 109575882
Dyskinesia 100.37 10.04 14 316608 51432 110221245
Acute febrile neutrophilic dermatosis 100.16 10.04 95 316527 4841 110267836
Facet joint syndrome 99.39 10.04 543 316079 96285 110176392
Dry skin 99.15 10.04 97 316525 107556 110165121
Drug hypersensitivity 97.91 10.04 1835 314787 452255 109820422
Cytokine release syndrome 96.70 10.04 40 316582 70266 110202411
Palmar-plantar erythrodysaesthesia syndrome 96.69 10.04 5 316617 41020 110231657
B-cell lymphoma 95.40 10.04 110 316512 7044 110265633
International normalised ratio increased 95.00 10.04 66 316556 86706 110185971
Accidental overdose 94.60 10.04 17 316605 51817 110220860
Accidental exposure to product 94.36 10.04 15 316607 49993 110222684
Granulomatosis with polyangiitis 94.35 10.04 79 316543 3411 110269266
Cognitive disorder 93.92 10.04 68 316554 87443 110185234
Laryngitis 93.73 10.04 301 316321 42110 110230567
Psoriatic arthropathy 93.33 10.04 917 315705 195844 110076833
Dysgeusia 92.79 10.04 42 316580 69943 110202734
Vision blurred 92.68 10.04 141 316481 128881 110143796
Overdose 91.94 10.04 351 316271 233443 110039234
Neoplasm progression 91.71 10.04 35 316587 64560 110208117
Clostridium difficile infection 90.07 10.04 341 316281 51788 110220889
Cough 89.89 10.04 866 315756 460775 109811902
Pruritus 89.86 10.04 1150 315472 580410 109692267
Blood pressure fluctuation 89.56 10.04 438 316184 74386 110198291
Granuloma skin 88.96 10.04 134 316488 11149 110261528
Vomiting 88.93 10.04 1959 314663 908716 109363961
Osteoarthritis 87.53 10.04 853 315769 181770 110090907
Squamous cell carcinoma of skin 87.41 10.04 168 316454 17035 110255642
Transient ischaemic attack 87.03 10.04 37 316585 63945 110208732
Intentional self-injury 86.85 10.04 5 316617 37424 110235253
Disorientation 86.76 10.04 47 316575 70624 110202053
Haematochezia 86.42 10.04 597 316025 114927 110157750
Tuberculosis 85.96 10.04 170 316452 17604 110255073
Chest discomfort 85.73 10.04 236 316386 173612 110099065
Aphthous ulcer 85.65 10.04 188 316434 20948 110251729
Lupus vulgaris 85.61 10.04 252 316370 33631 110239046
Antineutrophil cytoplasmic antibody positive 85.02 10.04 88 316534 4988 110267689
Acute myocardial infarction 84.93 10.04 69 316553 83708 110188969
Conjunctivitis allergic 84.84 10.04 102 316520 6829 110265848
Blood parathyroid hormone decreased 84.66 10.04 142 316480 12947 110259730
Inflammatory bowel disease 84.55 10.04 104 316518 7130 110265547
Peripheral venous disease 84.51 10.04 469 316153 83648 110189029
Aggression 84.20 10.04 32 316590 59178 110213499
Asthenia 84.05 10.04 1427 315195 687572 109585105
Palpitations 83.95 10.04 209 316413 159003 110113674
Metabolic acidosis 83.89 10.04 97 316525 99647 110173030
Pulmonary oedema 83.47 10.04 99 316523 100560 110172117
Ear infection 82.95 10.04 378 316244 62354 110210323
Epstein-Barr virus test positive 82.70 10.04 50 316572 1276 110271401
Dysarthria 81.95 10.04 72 316550 84049 110188628
Kaposi's sarcoma 81.65 10.04 40 316582 662 110272015
Leukopenia 81.39 10.04 715 315907 148076 110124601
Lip dry 81.35 10.04 528 316094 99555 110173122
Terminal ileitis 81.29 10.04 54 316568 1630 110271047
Renal cell carcinoma 81.23 10.04 104 316518 7426 110265251
Spirometry abnormal 80.94 10.04 89 316533 5408 110267269
Restlessness 80.68 10.04 30 316592 56229 110216448
Rhabdomyolysis 80.45 10.04 138 316484 120263 110152414
Joint range of motion decreased 80.43 10.04 611 316011 121221 110151456
Abdominal pain 80.28 10.04 1979 314643 511010 109761667
Mental status changes 79.31 10.04 61 316561 76061 110196616
Plasma cell myeloma 78.52 10.04 41 316581 62895 110209782
Hypersensitivity 78.08 10.04 1606 315016 402392 109870285
Hyperglycaemia 77.97 10.04 77 316545 85013 110187664
Type 2 diabetes mellitus 76.87 10.04 811 315811 176421 110096256
Drug level above therapeutic 76.67 10.04 127 316495 11461 110261216
Bone pain 76.13 10.04 46 316576 65087 110207590
Pyoderma gangrenosum 76.07 10.04 86 316536 5390 110267287
Gastrointestinal lymphoma 75.49 10.04 28 316594 221 110272456
Antinuclear antibody positive 75.31 10.04 111 316511 9057 110263620
Neurological symptom 75.14 10.04 149 316473 15459 110257218
Pericarditis 75.10 10.04 958 315664 218156 110054521
Pemphigus 74.76 10.04 941 315681 213629 110059048
Abortion spontaneous 74.57 10.04 242 316380 34040 110238637
Coronary artery disease 73.99 10.04 58 316564 71632 110201045
Hand deformity 73.90 10.04 953 315669 217553 110055124
Fluid retention 73.75 10.04 97 316525 94210 110178467
Defaecation urgency 73.44 10.04 107 316515 8640 110264037
Synovial fluid analysis 73.12 10.04 61 316561 2620 110270057
Therapy non-responder 73.06 10.04 730 315892 156577 110116100
Therapeutic response shortened 72.83 10.04 218 316404 29365 110243312
Injection site bruising 72.40 10.04 28 316594 51235 110221442
T-cell lymphoma 72.38 10.04 49 316573 1527 110271150
Chronic allograft nephropathy 72.16 10.04 55 316567 2071 110270606
Cardiogenic shock 72.06 10.04 37 316585 57301 110215376
Mite allergy 72.01 10.04 86 316536 5717 110266960
Histoplasmosis 71.99 10.04 63 316559 2890 110269787
Mycobacterial infection 71.16 10.04 75 316547 4342 110268335
Cytomegalovirus enteritis 70.74 10.04 42 316580 1036 110271641
Therapy interrupted 70.72 10.04 27 316595 49795 110222882
Pulmonary alveolar haemorrhage 70.35 10.04 169 316453 19981 110252696
Neck pain 70.12 10.04 597 316025 122533 110150144
Angina pectoris 70.05 10.04 46 316576 62249 110210428
Feeling abnormal 69.95 10.04 273 316349 180438 110092239
Altered state of consciousness 69.76 10.04 39 316583 57587 110215090
Mobility decreased 69.47 10.04 1009 315613 236413 110036264
Device expulsion 69.09 10.04 5 316617 30886 110241791
Sopor 68.87 10.04 11 316611 36535 110236142
Joint swelling 68.83 10.04 1707 314915 441138 109831539
Cardiac disorder 68.78 10.04 70 316552 76210 110196467
Abnormal behaviour 68.70 10.04 14 316608 39025 110233652
Confusional state 68.61 10.04 937 315685 467743 109804934
Myasthenia gravis crisis 68.43 10.04 50 316572 1764 110270913
Pain 68.16 10.04 2149 314473 952806 109319871
Skin ulcer 68.07 10.04 361 316261 63284 110209393
Ventricular tachycardia 67.89 10.04 29 316593 49980 110222697
Gait inability 67.31 10.04 641 315981 135735 110136942
Fibromyalgia 67.19 10.04 767 315855 170142 110102535
Mycotic allergy 67.02 10.04 84 316538 5870 110266807
Tenosynovitis stenosans 66.82 10.04 66 316556 3537 110269140
Rheumatoid factor negative 65.94 10.04 43 316579 1257 110271420
Fistula discharge 65.81 10.04 47 316575 1599 110271078
Hair follicle tumour benign 65.34 10.04 30 316592 426 110272251
Respiratory symptom 65.23 10.04 137 316485 14808 110257869
Anal stenosis 65.12 10.04 33 316589 589 110272088
Overlap syndrome 64.99 10.04 103 316519 8956 110263721
Dust allergy 64.92 10.04 83 316539 5918 110266759
Ulcer 64.79 10.04 270 316352 42846 110229831
Central nervous system lymphoma 64.48 10.04 60 316562 2984 110269693
Full blood count decreased 64.38 10.04 8 316614 32091 110240586
Gastrointestinal inflammation 64.30 10.04 105 316517 9364 110263313
Poisoning 64.27 10.04 5 316617 29100 110243577
Disturbance in attention 64.17 10.04 50 316572 61945 110210732
Small intestinal resection 63.73 10.04 40 316582 1093 110271584
Decreased appetite 62.78 10.04 971 315651 474875 109797802
Diabetic ketoacidosis 62.76 10.04 21 316601 42037 110230640
Injection site reaction 62.36 10.04 453 316169 88617 110184060
Phaeohyphomycosis 61.86 10.04 46 316576 1668 110271009
Angioedema 61.24 10.04 118 316504 98382 110174295
Hypomagnesaemia 60.85 10.04 50 316572 60320 110212357
Oedema peripheral 60.81 10.04 624 315998 328036 109944641
Anaphylactic shock 60.81 10.04 36 316586 51510 110221167
Dysphagia 60.11 10.04 231 316391 153369 110119308
Hepatic cytolysis 60.10 10.04 42 316580 55011 110217666
Inappropriate antidiuretic hormone secretion 59.86 10.04 12 316610 33839 110238838
Dysphonia 59.47 10.04 78 316544 75851 110196826
Extrapulmonary tuberculosis 59.43 10.04 30 316592 531 110272146
Multiple sclerosis relapse 59.39 10.04 35 316587 50205 110222472
Ventricular fibrillation 59.29 10.04 22 316600 41291 110231386
Epidermodysplasia verruciformis 59.20 10.04 28 316594 427 110272250
Disease progression 59.10 10.04 432 316190 243602 110029075
Device dislocation 58.72 10.04 10 316612 31694 110240983
Dyspnoea exertional 58.52 10.04 132 316490 103928 110168749
Toxic epidermal necrolysis 58.41 10.04 46 316576 56681 110215996
Impaired gastric emptying 58.30 10.04 122 316500 13153 110259524
Skin necrosis 58.22 10.04 164 316458 21348 110251329
Cholangitis sclerosing 58.03 10.04 61 316561 3521 110269156
Lymphadenitis 57.89 10.04 75 316547 5418 110267259
Hypocalcaemia 57.79 10.04 61 316561 65305 110207372
Aspergillus infection 57.69 10.04 183 316439 25433 110247244
Obesity 57.54 10.04 536 316086 112815 110159862
Gastrointestinal wall thickening 57.45 10.04 61 316561 3562 110269115
Uveitis 57.29 10.04 164 316458 21546 110251131
Renal failure 56.86 10.04 397 316225 226177 110046500
Ill-defined disorder 56.82 10.04 693 315929 156160 110116517
Pancreatitis 56.72 10.04 460 316162 93073 110179604
Ejection fraction decreased 56.63 10.04 23 316599 40857 110231820
Pleural effusion 56.41 10.04 289 316333 177420 110095257
Rash maculo-papular 56.36 10.04 78 316544 74144 110198533
Hypervolaemia 56.32 10.04 36 316586 49424 110223253
Faecal calprotectin abnormal 56.15 10.04 25 316597 329 110272348
Proteinuria 55.81 10.04 245 316377 39773 110232904
Spondylitis 55.50 10.04 109 316513 11229 110261448
Pulmonary embolism 55.20 10.04 373 316249 214101 110058576
Urinary tract infection 54.95 10.04 633 315989 325649 109947028
Folliculitis 54.91 10.04 727 315895 166926 110105751
Proctocolectomy 54.77 10.04 22 316600 220 110272457
Liver injury 54.68 10.04 665 315957 149748 110122929
Chest pain 54.15 10.04 755 315867 375620 109897057
Therapeutic reaction time decreased 53.96 10.04 71 316551 5208 110267469
Upper gastrointestinal haemorrhage 53.66 10.04 39 316583 50057 110222620
Grip strength 53.66 10.04 95 316527 9046 110263631
Nightmare 53.62 10.04 22 316600 38841 110233836
Varicella zoster virus infection 53.61 10.04 78 316544 6290 110266387
Haematoma 53.48 10.04 53 316569 58423 110214254
Encephalopathy 53.15 10.04 94 316528 80961 110191716
Heart transplant rejection 53.09 10.04 45 316577 1976 110270701
Pulmonary nocardiosis 52.21 10.04 50 316572 2579 110270098
Seronegative arthritis 52.03 10.04 116 316506 13061 110259616
Therapy cessation 51.97 10.04 32 316590 44825 110227852
Device issue 51.96 10.04 17 316605 34518 110238159
Osteonecrosis of jaw 51.93 10.04 37 316585 47980 110224697
Human herpesvirus 8 infection 51.92 10.04 43 316579 1828 110270849
Liver transplant rejection 51.83 10.04 60 316562 3858 110268819
Deep vein thrombosis 51.81 10.04 215 316407 139672 110133005
Immunosuppression 51.65 10.04 139 316483 17620 110255057
Lupus vasculitis 51.10 10.04 28 316594 590 110272087
Sinus bradycardia 51.00 10.04 11 316611 29472 110243205
Pneumonitis 50.86 10.04 88 316534 76443 110196234
Blood bilirubin increased 50.82 10.04 87 316535 75885 110196792
Atypical mycobacterial infection 50.80 10.04 50 316572 2668 110270009
Tinnitus 50.77 10.04 59 316563 60481 110212196
Crohn's disease 50.73 10.04 44 316578 1994 110270683
Angiocentric lymphoma 50.51 10.04 36 316586 1221 110271456
Blood calcium decreased 49.93 10.04 20 316602 35825 110236852
Thrombotic microangiopathy 49.79 10.04 190 316432 28959 110243718
Osteonecrosis 49.69 10.04 210 316412 33531 110239146
Enterocutaneous fistula 49.61 10.04 46 316576 2277 110270400
Taste disorder 49.54 10.04 339 316283 65048 110207629
Dislocation of vertebra 49.53 10.04 252 316370 43469 110229208
Oxygen saturation decreased 49.42 10.04 256 316366 156726 110115951
Tachycardia 49.38 10.04 413 316209 226232 110046445
Listeriosis 49.34 10.04 50 316572 2764 110269913
Weight increased 49.32 10.04 1561 315061 418083 109854594
Pancytopenia 49.29 10.04 859 315763 208754 110063923
Gestational hypertension 49.19 10.04 45 316577 2189 110270488
Loss of therapeutic response 48.45 10.04 47 316575 2463 110270214
Autoimmune hepatitis 48.32 10.04 121 316501 14683 110257994
Immunosuppressant drug level increased 48.32 10.04 105 316517 11619 110261058
Diarrhoea 48.30 10.04 2720 313902 1136785 109135892
Normochromic normocytic anaemia 48.29 10.04 112 316510 12945 110259732
Immunosuppressant drug level decreased 48.15 10.04 49 316573 2722 110269955
Duodenal ulcer perforation 48.00 10.04 745 315877 176955 110095722
Troponin increased 47.79 10.04 13 316609 29753 110242924
Extrapyramidal disorder 47.50 10.04 12 316610 28855 110243822
Delusion 47.45 10.04 6 316616 23749 110248928
Lymphopenia 47.25 10.04 234 316388 39936 110232741
Helicobacter infection 47.04 10.04 757 315865 181120 110091557
Haematemesis 47.03 10.04 60 316562 59048 110213629
Glossodynia 47.02 10.04 895 315727 221109 110051568
Intestinal anastomosis complication 46.98 10.04 23 316599 380 110272297
Lethargy 46.89 10.04 126 316496 93450 110179227
Vertigo 46.60 10.04 113 316509 86757 110185920
Forced expiratory volume decreased 46.53 10.04 111 316511 13065 110259612
Nodule 46.44 10.04 201 316421 32430 110240247
Blood sodium decreased 46.29 10.04 26 316596 38293 110234384
Withdrawal syndrome 46.24 10.04 16 316606 31364 110241313
Capillaritis 45.83 10.04 45 316577 2394 110270283
Episcleritis 45.74 10.04 34 316588 1232 110271445
Drug withdrawal syndrome 45.71 10.04 26 316596 38028 110234649
Skin exfoliation 45.47 10.04 116 316506 87535 110185142
Swollen tongue 45.26 10.04 64 316558 60298 110212379
Mucous stools 45.24 10.04 75 316547 6772 110265905
Injection site mass 45.07 10.04 8 316614 24605 110248072
Schizophrenia 44.87 10.04 5 316617 21821 110250856
Portal hypertension 44.68 10.04 85 316537 8552 110264125
Abdominal abscess 44.65 10.04 86 316536 8733 110263944
Hypophagia 44.44 10.04 51 316571 52575 110220102
Ischaemic stroke 44.35 10.04 32 316590 41231 110231446
Pollakiuria 44.05 10.04 37 316585 44158 110228519
Muscular weakness 43.84 10.04 975 315647 247493 110025184
Rectal abscess 43.83 10.04 46 316576 2650 110270027
Epstein Barr virus positive mucocutaneous ulcer 43.64 10.04 32 316590 1135 110271542
Muscle rigidity 43.59 10.04 8 316614 24023 110248654
Hallucination, visual 43.51 10.04 30 316592 39575 110233102
Medication error 43.49 10.04 155 316467 105211 110167466
Stevens-Johnson syndrome 43.48 10.04 42 316580 46859 110225818
Urinary incontinence 43.34 10.04 45 316577 48542 110224135
Meningitis listeria 42.81 10.04 33 316589 1264 110271413
Alopecia 42.63 10.04 1356 315266 363397 109909280
Disseminated cytomegaloviral infection 42.60 10.04 25 316597 603 110272074
Creatinine renal clearance decreased 42.41 10.04 6 316616 21809 110250868
Wound 42.33 10.04 923 315699 233514 110039163
Premature rupture of membranes 42.28 10.04 59 316563 4578 110268099
Enterovesical fistula 41.59 10.04 34 316588 1419 110271258
Peliosis hepatis 41.46 10.04 17 316605 180 110272497
Eye pruritus 41.41 10.04 21 316601 32754 110239923
Haematocrit decreased 41.28 10.04 79 316543 66038 110206639
Femur fracture 41.02 10.04 40 316582 44429 110228248
Generalised tonic-clonic seizure 40.98 10.04 58 316564 54622 110218055
Blood potassium decreased 40.95 10.04 57 316565 54057 110218620
Aplasia pure red cell 40.87 10.04 87 316535 9491 110263186
Hypophosphataemia 40.83 10.04 22 316600 33160 110239517
Mycobacterium chelonae infection 40.72 10.04 47 316575 3013 110269664
Subarachnoid haemorrhage 40.68 10.04 17 316605 29685 110242992
Head injury 40.49 10.04 38 316584 42979 110229698
Food intolerance 40.39 10.04 57 316565 4470 110268207
Contusion 40.35 10.04 450 316172 232911 110039766
Anastomotic stenosis 40.23 10.04 25 316597 671 110272006
Psychotic disorder 40.23 10.04 52 316570 50885 110221792
Anorectal stenosis 40.16 10.04 12 316610 43 110272634
Cutaneous T-cell lymphoma 40.11 10.04 49 316573 3335 110269342
Hallucination, auditory 39.70 10.04 13 316609 26384 110246293
Hyperthyroidism 39.67 10.04 17 316605 29244 110243433
Myopathy 39.63 10.04 159 316463 24801 110247876
Poor venous access 39.57 10.04 157 316465 24365 110248312
Gastrointestinal mucosa hyperaemia 39.56 10.04 23 316599 545 110272132
Epilepsy 39.49 10.04 450 316172 99759 110172918
Depressed mood 39.43 10.04 71 316551 60738 110211939
Abscess intestinal 39.42 10.04 48 316574 3256 110269421
Hepatic function abnormal 39.35 10.04 410 316212 88885 110183792
Papilloma viral infection 39.34 10.04 39 316583 2099 110270578
Serositis 39.31 10.04 34 316588 1535 110271142
Parkinsonism 38.95 10.04 8 316614 22179 110250498
Muscle spasms 38.74 10.04 1057 315565 277100 109995577
Coordination abnormal 38.70 10.04 12 316610 25216 110247461
Hot flush 38.58 10.04 82 316540 65954 110206723
Presyncope 38.51 10.04 50 316572 48837 110223840
Mycobacterium avium complex infection 38.33 10.04 64 316558 5813 110266864
Transplant dysfunction 38.29 10.04 78 316544 8250 110264427
Antisynthetase syndrome 38.27 10.04 18 316604 271 110272406
Body mass index abnormal 38.26 10.04 27 316595 901 110271776
Subdural haematoma 38.24 10.04 29 316593 36425 110236252
Rash erythematous 38.19 10.04 114 316508 81718 110190959
Melaena 38.02 10.04 88 316534 68669 110204008
Brain abscess 37.97 10.04 69 316553 6705 110265972
Large intestinal ulcer 37.93 10.04 63 316559 5698 110266979
Intestinal perforation 37.84 10.04 139 316483 20805 110251872
Abdominal adhesions 37.74 10.04 53 316569 4137 110268540
Myoclonus 37.60 10.04 24 316598 32974 110239703
Central nervous system lupus 37.35 10.04 31 316591 1322 110271355
Acute respiratory failure 37.21 10.04 102 316520 75158 110197519
Blood glucose decreased 37.10 10.04 19 316603 29469 110243208
Hospitalisation 37.06 10.04 247 316375 142246 110130431
Colitis 37.01 10.04 452 316170 101871 110170806
Device difficult to use 36.96 10.04 5 316617 18800 110253877
Weight decreased 36.93 10.04 1666 314956 466391 109806286
Arrhythmia 36.92 10.04 91 316531 69484 110203193
Cerebral haemorrhage 36.86 10.04 82 316540 64886 110207791
Mycobacterium abscessus infection 36.86 10.04 34 316588 1672 110271005
Injection site pruritus 36.82 10.04 56 316566 51202 110221475
Sneezing 36.80 10.04 23 316599 31961 110240716
Adjustment disorder with depressed mood 36.56 10.04 233 316389 43650 110229027
Metastases to central nervous system 36.56 10.04 10 316612 22807 110249870
Irritability 36.54 10.04 50 316572 47759 110224918
Oral pain 36.53 10.04 32 316590 37412 110235265
Mycoplasma infection 36.46 10.04 31 316591 1367 110271310
Red blood cell sedimentation rate abnormal 36.45 10.04 153 316469 24356 110248321
Non-cirrhotic portal hypertension 36.34 10.04 24 316598 717 110271960
Injection site haemorrhage 36.31 10.04 25 316597 33003 110239674
Sebaceous carcinoma 36.24 10.04 15 316607 163 110272514
Varicella 36.08 10.04 49 316573 3706 110268971
Product administration error 36.07 10.04 32 316590 37185 110235492
Visceral leishmaniasis 36.02 10.04 34 316588 1722 110270955
Body temperature fluctuation 35.90 10.04 49 316573 3724 110268953
Product storage error 35.81 10.04 9 316613 21719 110250958
Epstein-Barr virus infection reactivation 35.81 10.04 51 316571 4033 110268644
Granuloma 35.75 10.04 82 316540 9408 110263269
Injection site warmth 35.75 10.04 4 316618 17401 110255276
Abdominal distension 35.74 10.04 702 315920 174401 110098276
Electrolyte imbalance 35.69 10.04 32 316590 36996 110235681
Chorioretinopathy 35.26 10.04 38 316584 2257 110270420
B-lymphocyte count decreased 35.09 10.04 36 316586 2019 110270658
Actinic keratosis 35.03 10.04 68 316554 6945 110265732
Haemoglobin decreased 35.02 10.04 501 316121 248226 110024451
Herpes simplex hepatitis 34.98 10.04 24 316598 765 110271912
Mydriasis 34.97 10.04 10 316612 22147 110250530
Fistula of small intestine 34.71 10.04 27 316595 1048 110271629
Pneumatosis intestinalis 34.71 10.04 76 316546 8453 110264224
Product dose omission in error 34.63 10.04 12 316610 23500 110249177
Parvovirus B19 infection 34.61 10.04 42 316580 2839 110269838
Premature baby 34.55 10.04 55 316567 4800 110267877
Subcutaneous abscess 34.54 10.04 80 316542 9237 110263440
Cellulitis 34.53 10.04 215 316407 125801 110146876
Anxiety 34.50 10.04 739 315883 344339 109928338
Hepatosplenomegaly 34.46 10.04 67 316555 6852 110265825
Anorectal disorder 34.42 10.04 41 316581 2718 110269959
Cytomegalovirus chorioretinitis 34.26 10.04 68 316554 7060 110265617
Pneumonia cytomegaloviral 34.22 10.04 67 316555 6887 110265790
Neoplasm skin 34.16 10.04 44 316578 3160 110269517
Blood urea increased 34.02 10.04 66 316556 54891 110217786
Muscle twitching 33.79 10.04 22 316600 29913 110242764
Opportunistic infection 33.69 10.04 46 316576 3497 110269180
Febrile bone marrow aplasia 33.49 10.04 5 316617 17460 110255217
Chromophobe renal cell carcinoma 33.41 10.04 11 316611 58 110272619
Intestinal anastomosis 33.39 10.04 25 316597 916 110271761
Cystitis 33.02 10.04 89 316533 65947 110206730
Eosinophilia 32.97 10.04 73 316549 57863 110214814
Blood phosphorus increased 32.95 10.04 4 316618 16336 110256341
Blood potassium increased 32.94 10.04 28 316594 33221 110239456
Dermatitis atopic 32.82 10.04 16 316606 25525 110247152
Toxic skin eruption 32.76 10.04 19 316603 27496 110245181
Foetal growth restriction 32.70 10.04 42 316580 3008 110269669
Rectal discharge 32.69 10.04 26 316596 1043 110271634
Musculoskeletal pain 32.53 10.04 719 315903 182304 110090373
Infectious mononucleosis 32.49 10.04 36 316586 2206 110270471
Aspiration 32.40 10.04 24 316598 30509 110242168
Antiphospholipid syndrome 32.32 10.04 38 316584 2485 110270192
Speech disorder 32.30 10.04 81 316541 61488 110211189
Dementia 32.21 10.04 26 316596 31647 110241030
Loss of personal independence in daily activities 32.16 10.04 606 316016 149414 110123263
Tricuspid valve incompetence 32.16 10.04 14 316608 23859 110248818
Jejunal stenosis 32.10 10.04 13 316609 133 110272544
Pulmonary congestion 32.02 10.04 25 316597 30941 110241736
Lung abscess 31.92 10.04 54 316568 4958 110267719
Listeria sepsis 31.69 10.04 23 316599 803 110271874
Gait disturbance 31.66 10.04 583 316039 277625 109995052
Gestational diabetes 31.40 10.04 67 316555 7322 110265355
Polyomavirus viraemia 31.38 10.04 44 316578 3430 110269247
Infective pulmonary exacerbation of cystic fibrosis 31.36 10.04 3 316619 14768 110257909
Ear injury 31.29 10.04 17 316605 352 110272325
Emotional distress 31.25 10.04 50 316572 44797 110227880
Rectal stenosis 31.17 10.04 18 316604 421 110272256
Anger 31.08 10.04 8 316614 18999 110253678
Lymphoma 30.84 10.04 127 316495 20044 110252633
Strongyloidiasis 30.80 10.04 53 316569 4933 110267744
Rheumatoid factor positive 30.77 10.04 539 316083 131101 110141576
Second primary malignancy 30.73 10.04 7 316615 18061 110254616
Blood pressure decreased 30.69 10.04 198 316424 114893 110157784
Drug dose omission by device 30.68 10.04 3 316619 14513 110258164
Fear 30.61 10.04 14 316608 23179 110249498
Activated partial thromboplastin time prolonged 30.32 10.04 13 316609 22355 110250322
Paraesthesia oral 30.24 10.04 31 316591 33640 110239037
Sleep apnoea syndrome 30.21 10.04 43 316579 40404 110232273
Tenosynovitis 30.20 10.04 109 316513 16174 110256503
Neuralgia 30.20 10.04 58 316564 48420 110224257
Maternal exposure during breast feeding 30.15 10.04 48 316574 4190 110268487
Anti-neutrophil cytoplasmic antibody positive vasculitis 30.14 10.04 55 316567 5362 110267315
Infusion site reaction 29.99 10.04 115 316507 17567 110255110
Complications of transplanted kidney 29.93 10.04 66 316556 7376 110265301
Atrioventricular block first degree 29.90 10.04 3 316619 14222 110258455
Cardiotoxicity 29.82 10.04 6 316616 16875 110255802
American trypanosomiasis 29.81 10.04 20 316602 614 110272063
Skin neoplasm excision 29.75 10.04 33 316589 2025 110270652
Proctitis ulcerative 29.75 10.04 18 316604 460 110272217
Anaplastic large-cell lymphoma 29.75 10.04 14 316608 211 110272466
Anal cancer 29.60 10.04 22 316600 797 110271880
Ileal ulcer 29.54 10.04 31 316591 1786 110270891
Neurotoxicity 29.47 10.04 47 316575 42160 110230517
Ventricular extrasystoles 29.37 10.04 14 316608 22627 110250050
Biphasic mesothelioma 29.30 10.04 10 316612 60 110272617
Cytomegalovirus infection reactivation 29.28 10.04 117 316505 18216 110254461
Fungal endocarditis 29.20 10.04 22 316600 814 110271863
Prostate cancer 29.14 10.04 39 316583 37602 110235075
Salivary hypersecretion 29.13 10.04 7 316615 17414 110255263
Hypoxia 29.11 10.04 234 316388 129281 110143396
Rectal fissure 29.09 10.04 25 316597 1119 110271558
Thymoma 29.08 10.04 17 316605 407 110272270
Stiff person syndrome 29.08 10.04 20 316602 640 110272037
Pleuritic pain 29.06 10.04 107 316515 16033 110256644
Rash macular 29.02 10.04 41 316581 38645 110234032
Autoimmune disorder 29.01 10.04 301 316321 65182 110207495
Neuroendocrine carcinoma of the skin 28.77 10.04 30 316592 1715 110270962
Psychomotor hyperactivity 28.76 10.04 11 316611 20266 110252411
Blood calcium increased 28.73 10.04 8 316614 18032 110254645
Natural killer-cell leukaemia 28.60 10.04 11 316611 97 110272580
Injury 28.59 10.04 687 315935 176578 110096099
Glycosylated haemoglobin increased 28.57 10.04 16 316606 23603 110249074
Neuromyelitis optica spectrum disorder 28.56 10.04 28 316594 1487 110271190
Intestinal dilatation 28.55 10.04 43 316579 3577 110269100
Atrial flutter 28.54 10.04 17 316605 24245 110248432
X-ray abnormal 28.50 10.04 197 316425 37920 110234757
Renal mass 28.41 10.04 43 316579 3592 110269085
Allergy to chemicals 28.39 10.04 41 316581 3284 110269393
Akathisia 28.38 10.04 7 316615 17106 110255571
Skin haemorrhage 28.36 10.04 18 316604 24809 110247868
Affect lability 28.34 10.04 9 316613 18628 110254049
Cyanosis 28.31 10.04 26 316596 29715 110242962
Intentional dose omission 28.30 10.04 11 316611 20069 110252608
Agranulocytosis 28.13 10.04 87 316535 61673 110211004
Complications of transplanted lung 28.09 10.04 20 316602 677 110272000
Bone marrow failure 28.08 10.04 271 316351 57577 110215100
Maternal exposure timing unspecified 28.06 10.04 127 316495 20886 110251791
Sinus tachycardia 27.92 10.04 53 316569 44440 110228237
Lip swelling 27.89 10.04 65 316557 50602 110222075
Muscle injury 27.89 10.04 562 316060 140245 110132432
Diffuse large B-cell lymphoma stage IV 27.80 10.04 22 316600 876 110271801
Caesarean section 27.79 10.04 95 316527 13722 110258955
Splenic abscess 27.79 10.04 23 316599 977 110271700
Ankylosing spondylitis 27.69 10.04 103 316519 15509 110257168
Obliterative bronchiolitis 27.64 10.04 43 316579 3680 110268997
Hip fracture 27.64 10.04 36 316586 35115 110237562
Proctalgia 27.56 10.04 92 316530 13130 110259547
Chronic sinusitis 27.56 10.04 19 316603 25065 110247612
Thinking abnormal 27.55 10.04 5 316617 15135 110257542
Hypogammaglobulinaemia 27.30 10.04 122 316500 19954 110252723
Drug effective for unapproved indication 27.27 10.04 96 316526 14071 110258606
Parosmia 27.14 10.04 3 316619 13177 110259500
Rhegmatogenous retinal detachment 27.13 10.04 14 316608 260 110272417
Burning sensation 27.13 10.04 104 316518 69108 110203569
Visual impairment 27.11 10.04 538 316084 133890 110138787
Autoimmune haemolytic anaemia 27.08 10.04 79 316543 10488 110262189
Exposure via skin contact 27.05 10.04 3 316619 13144 110259533
Thiopurine methyltransferase decreased 27.04 10.04 15 316607 324 110272353
Metastases to bone 26.93 10.04 30 316592 31342 110241335
Crepitations 26.81 10.04 80 316542 10755 110261922
Oedema 26.79 10.04 431 316191 209545 110063132
Polyomavirus-associated nephropathy 26.74 10.04 67 316555 8134 110264543
Rhinorrhoea 26.68 10.04 178 316444 102488 110170189
Legionella infection 26.59 10.04 22 316600 934 110271743
Hyperphosphataemia 26.59 10.04 7 316615 16374 110256303
Retching 26.53 10.04 16 316606 22666 110250011
Cow pox 26.49 10.04 8 316614 30 110272647
Dystonia 26.47 10.04 21 316601 25784 110246893
Migraine 26.41 10.04 661 315961 170991 110101686
Eczema 26.21 10.04 112 316510 72181 110200496
Epstein-Barr viraemia 26.10 10.04 41 316581 3538 110269139
Gastrointestinal fistula 26.05 10.04 22 316600 961 110271716
Flushing 26.02 10.04 184 316438 104552 110168125
Blood test abnormal 25.97 10.04 26 316596 28528 110244149
Device malfunction 25.96 10.04 21 316601 25537 110247140
Haemolysis 25.94 10.04 101 316521 15538 110257139
Lupus myocarditis 25.92 10.04 10 316612 89 110272588
Graft loss 25.89 10.04 25 316597 1303 110271374
Paranoia 25.87 10.04 16 316606 22358 110250319
Paracoccidioides infection 25.72 10.04 10 316612 91 110272586
Small intestine carcinoma 25.56 10.04 23 316599 1095 110271582
Epicondylitis 25.50 10.04 34 316588 2526 110270151
Gamma-glutamyltransferase increased 25.42 10.04 90 316532 61219 110211458
Necrotising herpetic retinopathy 25.37 10.04 12 316610 183 110272494
Walking aid user 25.30 10.04 140 316482 24935 110247742
Squamous cell carcinoma of the tongue 25.30 10.04 20 316602 795 110271882
Lymphadenopathy 25.30 10.04 287 316335 63548 110209129
Arthritis reactive 25.19 10.04 20 316602 800 110271877
Complication associated with device 25.15 10.04 13 316609 20060 110252617
Radiculopathy 25.02 10.04 12 316610 19324 110253353
Torsade de pointes 24.99 10.04 17 316605 22583 110250094
Diabetes mellitus inadequate control 24.98 10.04 29 316593 29746 110242931
Ganglioneuroma 24.96 10.04 11 316611 141 110272536
Sleep disorder 24.91 10.04 745 315877 197899 110074778
Cutaneous leishmaniasis 24.91 10.04 15 316607 380 110272297
Lower respiratory tract infection 24.88 10.04 890 315732 242216 110030461
Food allergy 24.87 10.04 13 316609 19935 110252742
Serum sickness 24.85 10.04 45 316577 4361 110268316
Cardiomegaly 24.85 10.04 28 316594 29102 110243575
Sudden death 24.84 10.04 20 316602 24375 110248302
Pouchitis 24.82 10.04 25 316597 1372 110271305
Haemorrhage 24.80 10.04 191 316431 106501 110166176
Needle issue 24.77 10.04 10 316612 17830 110254847
Sleep disorder due to a general medical condition 24.74 10.04 243 316379 51869 110220808
Polyuria 24.54 10.04 10 316612 17728 110254949
Complications of bone marrow transplant 24.51 10.04 18 316604 640 110272037
Pseudopolyp 24.46 10.04 18 316604 642 110272035
Heart rate irregular 24.38 10.04 175 316447 34099 110238578
Chills 24.38 10.04 391 316231 190189 110082488
Salmonellosis 24.36 10.04 31 316591 2200 110270477
Eye infection toxoplasmal 24.35 10.04 19 316603 741 110271936
Enterostomy 24.26 10.04 12 316610 203 110272474
Pregnancy 24.19 10.04 238 316384 50829 110221848
Adverse event 24.18 10.04 442 316180 108367 110164310
Meningitis meningococcal 24.10 10.04 12 316610 206 110272471
HELLP syndrome 24.03 10.04 20 316602 856 110271821
Lacrimation increased 24.02 10.04 32 316590 30918 110241759
Rectal tenesmus 24.02 10.04 31 316591 2231 110270446
Rotator cuff syndrome 24.00 10.04 9 316613 16785 110255892
Diabetes mellitus 23.97 10.04 409 316213 98972 110173705
Transverse sinus thrombosis 23.96 10.04 19 316603 759 110271918
Carcinoid tumour pulmonary 23.93 10.04 15 316607 409 110272268
Non-Hodgkin's lymphoma 23.91 10.04 25 316597 1434 110271243
Stenosis 23.90 10.04 38 316584 3313 110269364
Mania 23.86 10.04 15 316607 20781 110251896
Hypothermia 23.86 10.04 24 316598 26278 110246399
Intestinal ulcer 23.82 10.04 32 316590 2395 110270282
Small intestinal obstruction 23.80 10.04 166 316456 32047 110240630
Growth retardation 23.76 10.04 33 316589 2549 110270128
Mood altered 23.74 10.04 16 316606 21359 110251318
Motor dysfunction 23.63 10.04 21 316601 24385 110248292
Pneumocystis jirovecii infection 23.63 10.04 44 316578 4356 110268321
Faeces discoloured 23.51 10.04 38 316584 33910 110238767
Skin burning sensation 23.36 10.04 17 316605 21808 110250869
Dysuria 23.29 10.04 91 316531 60140 110212537
Erectile dysfunction 23.28 10.04 12 316610 18544 110254133
Pyrexia 23.26 10.04 2235 314387 896030 109376647
Angina unstable 23.16 10.04 9 316613 16423 110256254
Pharyngeal oedema 23.15 10.04 9 316613 16419 110256258
Somatic delusion 23.05 10.04 18 316604 703 110271974
Hypovolaemia 23.05 10.04 17 316605 21657 110251020
Hiatus hernia 23.04 10.04 27 316595 27579 110245098
Tuberculosis of central nervous system 23.02 10.04 16 316606 521 110272156
Left ventricular dysfunction 23.01 10.04 20 316602 23473 110249204
Product dispensing error 22.96 10.04 9 316613 16336 110256341
Hospice care 22.96 10.04 4 316618 12469 110260208
Herpes zoster 22.95 10.04 437 316185 107942 110164735
Injection site rash 22.86 10.04 20 316602 23399 110249278
Therapy partial responder 22.86 10.04 183 316439 36878 110235799
Gallbladder polyp 22.81 10.04 23 316599 1264 110271413
Small intestine adenocarcinoma 22.78 10.04 12 316610 233 110272444
Laryngeal disorder 22.71 10.04 22 316600 1151 110271526
Rectal cancer metastatic 22.65 10.04 16 316606 535 110272142
Eccrine carcinoma 22.63 10.04 7 316615 29 110272648
Skin abrasion 22.51 10.04 9 316613 16142 110256535
Angiolymphoid hyperplasia with eosinophilia 22.50 10.04 10 316612 131 110272546
Pulmonary granuloma 22.48 10.04 32 316590 2529 110270148
Injection site induration 22.44 10.04 3 316619 11380 110261297
Dermatomyositis 22.35 10.04 43 316579 4363 110268314
Bowel movement irregularity 22.32 10.04 60 316562 7600 110265077
Dizziness postural 22.32 10.04 7 316615 14602 110258075
Injection site inflammation 22.31 10.04 45 316577 4726 110267951
Device leakage 22.28 10.04 9 316613 16039 110256638
Retinal scar 22.26 10.04 15 316607 464 110272213
Splenomegaly 22.25 10.04 133 316489 24365 110248312
Hyperlipidaemia 22.23 10.04 43 316579 35805 110236872
Arterial occlusive disease 22.22 10.04 8 316614 15300 110257377
Circulatory collapse 22.22 10.04 57 316565 42936 110229741
Gastrointestinal ulcer 22.13 10.04 42 316580 4218 110268459
Device breakage 22.13 10.04 6 316616 13763 110258914
Micturition urgency 22.08 10.04 14 316608 19306 110253371
Blood pressure abnormal 22.07 10.04 19 316603 22405 110250272
Blood creatine phosphokinase increased 21.97 10.04 121 316501 72956 110199721
Sinusitis 21.95 10.04 664 315958 296024 109976653
Eating disorder 21.89 10.04 34 316588 30824 110241853
Vaginal discharge 21.85 10.04 12 316610 17896 110254781
Rheumatoid lung 21.83 10.04 42 316580 4262 110268415
Headache 21.80 10.04 2203 314419 880174 109392503
Feeling cold 21.75 10.04 40 316582 33947 110238730
Skin discolouration 21.70 10.04 70 316552 48976 110223701
Urinary tract injury 21.68 10.04 6 316616 15 110272662
Abnormal dreams 21.64 10.04 5 316617 12775 110259902
Tonsillitis 21.63 10.04 62 316560 8151 110264526
Product quality issue 21.60 10.04 326 316296 76973 110195704
Nocardia sepsis 21.48 10.04 8 316614 64 110272613
Gangrene 21.36 10.04 10 316612 16331 110256346
Shock haemorrhagic 21.32 10.04 28 316594 27219 110245458
Acute pulmonary oedema 21.31 10.04 11 316611 16985 110255692
Adrenal insufficiency 21.29 10.04 57 316565 42333 110230344
Anaplastic large cell lymphoma T- and null-cell types 21.23 10.04 11 316611 206 110272471
Meningitis cryptococcal 21.19 10.04 44 316578 4718 110267959
Impaired healing 21.08 10.04 724 315898 195993 110076684
Pulmonary hypertension 20.99 10.04 84 316538 55136 110217541
Bradykinesia 20.89 10.04 3 316619 10785 110261892
Pain in extremity 20.84 10.04 1642 314980 485476 109787201
Chronic myeloid leukaemia 20.82 10.04 41 316581 4232 110268445
Weber tuning fork test abnormal 20.81 10.04 9 316613 110 110272567
Electrocardiogram abnormal 20.78 10.04 14 316608 18695 110253982
Acute haemorrhagic ulcerative colitis 20.66 10.04 9 316613 112 110272565
Diffuse large B-cell lymphoma stage I 20.64 10.04 6 316616 19 110272658
Ileectomy 20.58 10.04 12 316610 286 110272391
Pericardial effusion 20.53 10.04 89 316533 57128 110215549
Meningoencephalitis viral 20.51 10.04 15 316607 530 110272147
Nervousness 20.51 10.04 47 316575 36804 110235873
Drug tolerance 20.50 10.04 98 316524 16487 110256190
Transplant failure 20.47 10.04 48 316574 5587 110267090
Mediastinal effusion 20.46 10.04 8 316614 74 110272603
Crying 20.40 10.04 26 316596 25602 110247075
Nicotinic acid deficiency 20.37 10.04 11 316611 225 110272452
Lower gastrointestinal haemorrhage 20.31 10.04 14 316608 18472 110254205
Blood uric acid increased 20.28 10.04 19 316603 21510 110251167
Renal disorder 20.27 10.04 73 316549 49406 110223271
Limb injury 20.15 10.04 49 316573 37587 110235090
Intestinal mass 20.12 10.04 23 316599 1459 110271218
Herpes simplex 20.10 10.04 94 316528 15670 110257007
Jaw fracture 20.09 10.04 34 316588 3122 110269555
Intestinal mucosal hypertrophy 20.08 10.04 14 316608 458 110272219
Drug specific antibody 20.08 10.04 32 316590 2796 110269881
Lung infiltration 20.05 10.04 130 316492 24498 110248179
Pseudopolyposis 20.04 10.04 9 316613 121 110272556
Kidney fibrosis 20.03 10.04 41 316581 4351 110268326
Respiratory tract congestion 20.03 10.04 36 316586 30821 110241856
Apnoea 20.02 10.04 7 316615 13632 110259045
Drug specific antibody absent 19.98 10.04 11 316611 234 110272443
Lymphocyte count decreased 19.95 10.04 90 316532 57153 110215524
Acute coronary syndrome 19.95 10.04 22 316600 23090 110249587
Cutaneous nocardiosis 19.86 10.04 12 316610 306 110272371
Sacroiliitis 19.85 10.04 44 316578 4934 110267743
Aphasia 19.83 10.04 94 316528 58903 110213774
Gastrointestinal scarring 19.79 10.04 14 316608 469 110272208
Hyperthermia 19.77 10.04 19 316603 21253 110251424
Pain of skin 19.68 10.04 17 316605 20012 110252665
Sinus disorder 19.66 10.04 40 316582 32688 110239989
Therapeutic product effect variable 19.63 10.04 31 316591 2687 110269990
Gastrointestinal stenosis 19.61 10.04 13 316609 391 110272286
Restless legs syndrome 19.59 10.04 25 316597 24601 110248076
Pallor 19.55 10.04 89 316533 56378 110216299
B-cell unclassifiable lymphoma high grade 19.54 10.04 5 316617 8 110272669
Neutrophilic dermatosis 19.52 10.04 17 316605 775 110271902
Chronic gastrointestinal bleeding 19.46 10.04 14 316608 482 110272195
Macular degeneration 19.38 10.04 20 316602 21639 110251038
Steroid diabetes 19.35 10.04 45 316577 5209 110267468
Tuberculosis of eye 19.32 10.04 8 316614 87 110272590
Phospholipidosis 19.25 10.04 12 316610 324 110272353
Aspartate aminotransferase increased 19.18 10.04 332 316290 159604 110113073
Infected fistula 19.11 10.04 14 316608 496 110272181
Synovial cyst 19.11 10.04 74 316548 11356 110261321
Gastric ulcer haemorrhage 19.11 10.04 3 316619 10091 110262586
Prostatic specific antigen increased 19.10 10.04 6 316616 12505 110260172
Ketoacidosis 19.09 10.04 3 316619 10084 110262593
Tachypnoea 19.02 10.04 54 316568 39341 110233336
Hodgkin's disease 19.00 10.04 17 316605 803 110271874
Cerebral infarction 18.98 10.04 80 316542 51758 110220919
Premature separation of placenta 18.93 10.04 23 316599 1557 110271120
Impaired work ability 18.85 10.04 135 316487 26284 110246393
Diastolic dysfunction 18.85 10.04 6 316616 12398 110260279
Arthritis enteropathic 18.85 10.04 13 316609 418 110272259
Placental necrosis 18.83 10.04 5 316617 10 110272667
Cutaneous T-cell lymphoma refractory 18.83 10.04 6 316616 28 110272649
Acne conglobata 18.83 10.04 6 316616 28 110272649
Abdominal pain lower 18.76 10.04 176 316446 37107 110235570
Cardiac failure chronic 18.76 10.04 8 316614 13803 110258874
Myalgia 18.67 10.04 489 316133 221892 110050785
Blood thyroid stimulating hormone increased 18.60 10.04 6 316616 12295 110260382
Brain stem syndrome 18.55 10.04 21 316601 1318 110271359
Gingival pain 18.55 10.04 11 316611 15725 110256952
Dyspepsia 18.53 10.04 695 315927 190270 110082407
Infection reactivation 18.50 10.04 38 316584 4043 110268634
Polyneuropathy 18.49 10.04 40 316582 31972 110240705
Cytomegalovirus duodenitis 18.48 10.04 9 316613 147 110272530
Scratch 18.48 10.04 7 316615 12972 110259705
Cytomegalovirus test positive 18.42 10.04 53 316569 6983 110265694
Blood glucose abnormal 18.33 10.04 7 316615 12909 110259768
Leiomyosarcoma metastatic 18.33 10.04 6 316616 31 110272646
Heparin-induced thrombocytopenia 18.32 10.04 5 316617 11419 110261258
Acute generalised exanthematous pustulosis 18.28 10.04 21 316601 21643 110251034
Skin fissures 18.27 10.04 26 316596 24432 110248245
Atrioventricular block 18.25 10.04 13 316609 16864 110255813
Hemiplegia 18.25 10.04 23 316599 22759 110249918
Illness 18.22 10.04 149 316473 82022 110190655
Sepsis neonatal 18.19 10.04 8 316614 102 110272575
Cytomegalovirus oesophagitis 18.17 10.04 18 316604 968 110271709
Asphyxia 18.12 10.04 9 316613 14206 110258471
Marrow hyperplasia 18.12 10.04 24 316598 1772 110270905
Hypertensive crisis 18.11 10.04 26 316596 24346 110248331
Mesenteritis 18.10 10.04 12 316610 361 110272316
Emotional disorder 18.07 10.04 12 316610 16148 110256529
Splenic embolism 18.03 10.04 10 316612 216 110272461
Pyoderma 18.01 10.04 14 316608 543 110272134
Tension headache 17.89 10.04 3 316619 9615 110263062
Unevaluable event 17.85 10.04 98 316524 59129 110213548
Short-bowel syndrome 17.81 10.04 16 316606 760 110271917
Muscle fatigue 17.80 10.04 37 316585 3970 110268707
Drug level abnormal 17.79 10.04 14 316608 553 110272124
Eructation 17.77 10.04 9 316613 14048 110258629
Product substitution issue 17.74 10.04 24 316598 23037 110249640
Glomerular filtration rate decreased 17.73 10.04 35 316587 28921 110243756
Panic attack 17.70 10.04 35 316587 28905 110243772
Abscess rupture 17.70 10.04 12 316610 375 110272302
Injection site urticaria 17.67 10.04 14 316608 17201 110255476
Myasthenic syndrome 17.66 10.04 20 316602 1256 110271421
Respiratory distress 17.60 10.04 120 316502 68754 110203923
Malignant melanoma 17.51 10.04 95 316527 16796 110255881
Pelvic abscess 17.51 10.04 29 316593 2617 110270060
Infusion site thrombosis 17.45 10.04 11 316611 303 110272374
Trichostasis spinulosa 17.41 10.04 5 316617 15 110272662
Cutaneous malacoplakia 17.40 10.04 9 316613 168 110272509
Infective scleritis 17.34 10.04 8 316614 115 110272562
Periumbilical abscess 17.32 10.04 11 316611 307 110272370
Peripheral T-cell lymphoma unspecified stage IV 17.31 10.04 6 316616 38 110272639
Peritoneal tuberculosis 17.30 10.04 14 316608 576 110272101
Tonsil cancer 17.28 10.04 20 316602 1286 110271391
Wrist deformity 17.26 10.04 32 316590 3157 110269520
Neuropsychiatric lupus 17.24 10.04 10 316612 236 110272441
Renal transplant failure 17.23 10.04 29 316593 2651 110270026
Trichodysplasia spinulosa 17.22 10.04 18 316604 1032 110271645
Hypoaesthesia 17.22 10.04 1081 315541 313142 109959535
Enterocolonic fistula 17.16 10.04 9 316613 173 110272504
Cytomegalovirus syndrome 17.16 10.04 11 316611 312 110272365
Hypersomnia 17.11 10.04 34 316588 28027 110244650
Bronchopulmonary aspergillosis 17.10 10.04 145 316477 29718 110242959
Skin irritation 17.09 10.04 13 316609 16306 110256371
Autoimmune neutropenia 17.00 10.04 15 316607 696 110271981
Polychondritis 16.98 10.04 17 316605 926 110271751
Sebaceous adenoma 16.92 10.04 6 316616 41 110272636
Transient hypogammaglobulinaemia of infancy 16.92 10.04 6 316616 41 110272636
Tractional retinal detachment 16.86 10.04 8 316614 123 110272554
Gastroenteritis clostridial 16.83 10.04 18 316604 1060 110271617
Microscopic polyangiitis 16.82 10.04 13 316609 500 110272177
Lupus endocarditis 16.79 10.04 10 316612 248 110272429
Pulmonary mass 16.77 10.04 172 316450 37129 110235548
Palatal ulcer 16.76 10.04 10 316612 249 110272428
Irritable bowel syndrome 16.75 10.04 601 316021 163614 110109063
Dyschezia 16.73 10.04 35 316587 3772 110268905
Pseudoxanthoma elasticum-like syndrome 16.67 10.04 4 316618 4 110272673
Arteriospasm coronary 16.57 10.04 3 316619 9097 110263580
Ileocolostomy 16.56 10.04 6 316616 44 110272633
Burkitt's lymphoma stage III 16.51 10.04 5 316617 19 110272658
Renal tubular atrophy 16.50 10.04 26 316596 2250 110270427
Epiglottic erythema 16.45 10.04 7 316615 82 110272595
Bronchitis 16.35 10.04 334 316288 156698 110115979
Cholesteatoma 16.32 10.04 9 316613 192 110272485
Product administration interrupted 16.23 10.04 6 316616 11286 110261391
Erythropoiesis abnormal 16.21 10.04 14 316608 631 110272046
Skin papilloma 16.21 10.04 50 316572 6846 110265831
Hyperventilation 16.18 10.04 3 316619 8944 110263733
Product monitoring error 16.13 10.04 3 316619 8924 110263753
Optic neuritis 16.12 10.04 69 316553 11078 110261599
Skin lesion 16.11 10.04 222 316400 51409 110221268
Affective disorder 16.11 10.04 6 316616 11235 110261442
Dysplasia 16.09 10.04 23 316599 1825 110270852
Synovial disorder 16.06 10.04 30 316592 2977 110269700
Anogenital warts 16.05 10.04 18 316604 1118 110271559
Device occlusion 16.03 10.04 12 316610 15173 110257504
Small intestine operation 16.00 10.04 6 316616 49 110272628
Glomerulosclerosis 15.97 10.04 19 316603 1258 110271419
Blood creatinine increased 15.92 10.04 400 316222 182489 110090188
Complication of device insertion 15.91 10.04 3 316619 8835 110263842
Lymphocytic infiltration 15.89 10.04 24 316598 2001 110270676
Euphoric mood 15.88 10.04 3 316619 8824 110263853
Testicular cancer metastatic 15.87 10.04 7 316615 90 110272587
Papilloedema 15.84 10.04 52 316570 7357 110265320
Anal ulcer 15.82 10.04 23 316599 1853 110270824
Tumour lysis syndrome 15.79 10.04 41 316581 30760 110241917
Haemorrhagic stroke 15.75 10.04 10 316612 13779 110258898
Paronychia 15.73 10.04 6 316616 11075 110261602
Primary biliary cholangitis 15.72 10.04 20 316602 1419 110271258
Cardiac failure acute 15.71 10.04 28 316594 24050 110248627
Retinal vasculitis 15.68 10.04 24 316598 2025 110270652
Eye ulcer 15.67 10.04 11 316611 364 110272313
Porokeratosis 15.62 10.04 10 316612 283 110272394
Hodgkin's disease nodular sclerosis 15.57 10.04 5 316617 24 110272653
Complications of intestinal transplant 15.57 10.04 5 316617 24 110272653
Procedural pain 15.57 10.04 51 316571 35514 110237163
Swelling face 15.56 10.04 179 316443 92142 110180535
Hallucinations, mixed 15.54 10.04 3 316619 8690 110263987
Cholecystitis chronic 15.53 10.04 4 316618 9496 110263181
Osteosarcoma recurrent 15.53 10.04 8 316614 148 110272529
Hypokinesia 15.53 10.04 24 316598 21802 110250875
Cutaneous tuberculosis 15.50 10.04 10 316612 287 110272390
Aspergillosis oral 15.49 10.04 6 316616 54 110272623
Spinal operation 15.48 10.04 6 316616 10966 110261711
Hirsutism 15.44 10.04 22 316600 1741 110270936
Dermatitis psoriasiform 15.44 10.04 33 316589 3611 110269066
Cardiomyopathy 15.43 10.04 47 316575 33478 110239199
Anti-cyclic citrullinated peptide antibody 15.41 10.04 104 316518 19860 110252817
Mastoidectomy 15.41 10.04 4 316618 7 110272670
Palisaded neutrophilic granulomatous dermatitis 15.41 10.04 5 316617 25 110272652
Epstein-Barr virus antibody positive 15.39 10.04 14 316608 676 110272001
Drain placement 15.38 10.04 9 316613 216 110272461
Lymphadenitis bacterial 15.34 10.04 7 316615 98 110272579
Hepatitis viral 15.33 10.04 20 316602 1455 110271222
Cryptococcosis 15.27 10.04 38 316584 4593 110268084
Stress 15.24 10.04 211 316411 105137 110167540
Joint tuberculosis 15.23 10.04 9 316613 220 110272457
Colitis ischaemic 15.21 10.04 17 316605 17733 110254944
Bundle branch block left 15.20 10.04 9 316613 12879 110259798
Muscle tightness 15.16 10.04 12 316610 14750 110257927
Blood alkaline phosphatase increased 15.10 10.04 130 316492 70805 110201872
Hepatitis B 15.08 10.04 61 316561 9551 110263126
Vascular device infection 15.06 10.04 15 316607 16497 110256180
Decubitus ulcer 15.04 10.04 18 316604 18218 110254459
Humerus fracture 15.03 10.04 6 316616 10770 110261907
Anastomotic ulcer 14.99 10.04 17 316605 1069 110271608
Pseudomonas aeruginosa meningitis 14.96 10.04 7 316615 104 110272573
IgA nephropathy 14.92 10.04 30 316592 3143 110269534
Alanine aminotransferase increased 14.92 10.04 406 316216 183367 110089310
Breast pain 14.91 10.04 5 316617 9995 110262682
Back disorder 14.89 10.04 23 316599 20899 110251778
Nerve injury 14.88 10.04 6 316616 10707 110261970
Chromoblastomycosis 14.88 10.04 8 316614 162 110272515
Glomerulonephritis proliferative 14.86 10.04 12 316610 492 110272185
Nocturia 14.85 10.04 16 316606 16974 110255703
Stress cardiomyopathy 14.83 10.04 14 316608 15792 110256885
Anti-erythropoietin antibody negative 14.79 10.04 10 316612 311 110272366
Lymph node tuberculosis 14.76 10.04 17 316605 1087 110271590
Drug use disorder 14.74 10.04 18 316604 18056 110254621
Delirium 14.72 10.04 285 316337 134740 110137937
Cutaneous T-cell lymphoma stage III 14.65 10.04 5 316617 30 110272647
Hepatocellular injury 14.61 10.04 85 316537 50557 110222120
Adenocarcinoma of the cervix 14.60 10.04 9 316613 238 110272439
Blood chloride decreased 14.60 10.04 4 316618 9111 110263566
Latent tuberculosis 14.58 10.04 34 316588 3943 110268734
Ageusia 14.56 10.04 21 316601 19624 110253053
Malignant polyp 14.54 10.04 8 316614 170 110272507
Apathy 14.53 10.04 15 316607 16224 110256453
Nasal congestion 14.52 10.04 196 316426 98086 110174591
Exercise tolerance increased 14.51 10.04 5 316617 31 110272646
Lung neoplasm malignant 14.49 10.04 49 316573 33793 110238884
Nephropathy toxic 14.48 10.04 131 316491 27347 110245330
Rhinitis allergic 14.46 10.04 18 316604 17904 110254773
Carotid artery perforation 14.45 10.04 4 316618 10 110272667
Oesophageal squamous cell carcinoma 14.45 10.04 12 316610 512 110272165
Sinus node dysfunction 14.43 10.04 4 316618 9043 110263634
Candida infection 14.41 10.04 205 316417 47804 110224873
Gastrointestinal bacterial infection 14.38 10.04 19 316603 1399 110271278
Shock 14.38 10.04 92 316530 53496 110219181
Atrioventricular block complete 14.36 10.04 22 316600 20060 110252617
Haematuria 14.36 10.04 160 316462 82845 110189832
Hypercapnia 14.32 10.04 7 316615 11152 110261525
Campylobacter infection 14.32 10.04 25 316597 2354 110270323
Deep vein thrombosis postoperative 14.29 10.04 244 316378 59047 110213630
Ocular sarcoidosis 14.28 10.04 7 316615 116 110272561
Lymphoedema 14.27 10.04 13 316609 14916 110257761
Granulomatous liver disease 14.21 10.04 20 316602 1564 110271113
Exposure to SARS-CoV-2 14.21 10.04 28 316594 2891 110269786
Primary mediastinal large B-cell lymphoma stage IV 14.18 10.04 4 316618 11 110272666
Mental impairment 14.17 10.04 27 316595 22612 110250065
Urinary casts present 14.17 10.04 7 316615 118 110272559
Hypertension 14.17 10.04 1668 314954 508416 109764261
Oropharyngeal squamous cell carcinoma 14.16 10.04 10 316612 334 110272343
Acquired gene mutation 14.12 10.04 27 316595 2727 110269950
Cardiac murmur 14.04 10.04 31 316591 24597 110248080
Porphyria acute 14.00 10.04 97 316525 18683 110253994
Skin cancer 13.94 10.04 93 316529 17691 110254986
Chronic hepatitis 13.91 10.04 21 316601 1751 110270926
Infertility 13.90 10.04 14 316608 768 110271909
Gastric haemorrhage 13.90 10.04 15 316607 15900 110256777
Mycoplasma test positive 13.87 10.04 9 316613 261 110272416
Multiple allergies 13.86 10.04 9 316613 12254 110260423
Systemic candida 13.86 10.04 61 316561 9913 110262764
Tonsillar hypertrophy 13.85 10.04 22 316600 1916 110270761
Malignant neoplasm of conjunctiva 13.82 10.04 6 316616 74 110272603
Haemophilus infection 13.80 10.04 27 316595 2773 110269904
Dermatopathic lymphadenopathy 13.76 10.04 5 316617 37 110272640
Postoperative abscess 13.73 10.04 15 316607 905 110271772
Blood lactic acid increased 13.72 10.04 15 316607 15806 110256871
Large intestine erosion 13.71 10.04 7 316615 127 110272550
Mitochondrial neurogastrointestinal encephalopathy 13.69 10.04 4 316618 13 110272664
Dermatofibrosarcoma protuberans 13.68 10.04 6 316616 76 110272601
Dengue fever 13.67 10.04 18 316604 1321 110271356
DNA antibody 13.64 10.04 5 316617 38 110272639
Oral lichen planus 13.63 10.04 15 316607 912 110271765
Jaundice cholestatic 13.63 10.04 13 316609 14595 110258082
Pneumonia legionella 13.62 10.04 31 316591 3538 110269139
Cholecystitis 13.62 10.04 34 316588 25848 110246829
Diaphragmatic injury 13.61 10.04 7 316615 129 110272548
Pulmonary amyloidosis 13.61 10.04 6 316616 77 110272600
Narcotic bowel syndrome 13.60 10.04 9 316613 270 110272407
Hemiparesis 13.58 10.04 72 316550 43831 110228846
Fear of injection 13.54 10.04 56 316566 8855 110263822
Myelitis 13.50 10.04 29 316593 3184 110269493
Mouth ulceration 13.44 10.04 203 316419 47935 110224742
Cervix carcinoma 13.42 10.04 25 316597 2476 110270201
Testicular abscess 13.41 10.04 6 316616 80 110272597
Erythema multiforme 13.35 10.04 25 316597 21072 110251605
Hypopnoea 13.35 10.04 8 316614 11372 110261305
Laryngeal mass 13.34 10.04 6 316616 81 110272596
Toxoplasmosis 13.34 10.04 29 316593 3210 110269467
Intestinal fibrosis 13.31 10.04 9 316613 280 110272397
Eosinophilic bronchitis 13.29 10.04 12 316610 574 110272103
Retinal injury 13.27 10.04 11 316611 468 110272209
Respiratory acidosis 13.26 10.04 12 316610 13814 110258863
Stomatitis 13.24 10.04 921 315701 269321 110003356
Delayed puberty 13.24 10.04 8 316614 204 110272473
Abnormal faeces 13.22 10.04 57 316565 9179 110263498
Germ cell cancer 13.20 10.04 8 316614 205 110272472
Pulmonary paracoccidioidomycosis 13.04 10.04 4 316618 16 110272661
Hepatic infection bacterial 13.01 10.04 5 316617 44 110272633
Pharyngitis bacterial 13.00 10.04 9 316613 291 110272386
Urticaria 13.00 10.04 1071 315551 317786 109954891
Cervical dysplasia 13 10.04 26 316596 2714 110269963
Anhedonia 12.97 10.04 15 316607 15413 110257264
Adenocarcinoma of colon 12.93 10.04 43 316579 6125 110266552
Dissociation 12.90 10.04 6 316616 9836 110262841
Antinuclear antibody negative 12.84 10.04 7 316615 146 110272531
Immune effector cell-associated neurotoxicity syndrome 12.84 10.04 14 316608 14768 110257909
Perirectal abscess 12.83 10.04 23 316599 2211 110270466
Bronchospasm 12.80 10.04 44 316578 30195 110242482
Vitello-intestinal duct remnant 12.80 10.04 7 316615 147 110272530
Colectomy total 12.79 10.04 11 316611 493 110272184
Pyometra 12.78 10.04 6 316616 90 110272587
B-cell lymphoma stage IV 12.78 10.04 6 316616 90 110272587
Graft versus host disease in lung 12.77 10.04 17 316605 1261 110271416
Vasculitis necrotising 12.76 10.04 19 316603 1564 110271113
Antineutrophil cytoplasmic antibody increased 12.74 10.04 9 316613 301 110272376
Squamous cell carcinoma of the oral cavity 12.73 10.04 13 316609 725 110271952
Bradyphrenia 12.73 10.04 9 316613 11719 110260958
Cholelithiasis 12.73 10.04 118 316504 63304 110209373
Sensory processing disorder 12.72 10.04 5 316617 47 110272630
Upper-airway cough syndrome 12.71 10.04 16 316606 15841 110256836
Fracture 12.70 10.04 33 316589 24755 110247922
Status epilepticus 12.66 10.04 47 316575 31524 110241153
Dysstasia 12.65 10.04 50 316572 32936 110239741
Enzyme abnormality 12.64 10.04 10 316612 398 110272279
Mycobacterium kansasii infection 12.60 10.04 10 316612 400 110272277
Idiopathic intracranial hypertension 12.58 10.04 32 316590 3920 110268757
Gastrooesophageal reflux disease 12.55 10.04 633 315989 179343 110093334
Biopsy muscle abnormal 12.54 10.04 5 316617 49 110272628
Heart rate decreased 12.52 10.04 318 316304 82438 110190239
HCoV-NL63 infection 12.51 10.04 3 316619 3 110272674
Precursor T-lymphoblastic lymphoma/leukaemia stage I 12.51 10.04 3 316619 3 110272674
Enterostomy closure 12.51 10.04 3 316619 3 110272674
Spondyloarthropathy 12.48 10.04 19 316603 1595 110271082
Behaviour disorder 12.46 10.04 6 316616 9641 110263036
Hypovolaemic shock 12.46 10.04 14 316608 14569 110258108
Renal function test abnormal 12.45 10.04 5 316617 8941 110263736
Proteus infection 12.43 10.04 26 316596 2802 110269875
Accident 12.43 10.04 8 316614 10944 110261733
Extra dose administered 12.34 10.04 10 316612 12149 110260528
Peritoneal candidiasis 12.33 10.04 4 316618 20 110272657
Tearfulness 12.31 10.04 3 316619 7392 110265285
Oesophageal carcinoma 12.30 10.04 9 316613 11515 110261162
Respiratory gas exchange disorder 12.30 10.04 14 316608 884 110271793
Stress at work 12.29 10.04 17 316605 1308 110271369
Mucocutaneous leishmaniasis 12.29 10.04 11 316611 520 110272157
Leiomyosarcoma 12.22 10.04 10 316612 418 110272259
Cytomegalovirus hepatitis 12.20 10.04 14 316608 892 110271785
Oesophagopleural fistula 12.19 10.04 5 316617 53 110272624
Syringe issue 12.19 10.04 6 316616 9519 110263158
Mixed liver injury 12.18 10.04 10 316612 12069 110260608
Small intestinal anastomosis 12.17 10.04 4 316618 21 110272656
Faecaluria 12.17 10.04 4 316618 21 110272656
Diffuse large B-cell lymphoma stage III 12.16 10.04 6 316616 101 110272576
Supraventricular tachycardia 12.15 10.04 33 316589 24389 110248288
Skin swelling 12.11 10.04 4 316618 8076 110264601
Incontinence 12.11 10.04 18 316604 16617 110256060
Histone antibody positive 12.11 10.04 7 316615 164 110272513
Post procedural discharge 12.11 10.04 13 316609 769 110271908
Stoma complication 12.11 10.04 15 316607 1036 110271641
Hepatic failure 12.09 10.04 132 316490 68607 110204070
Muscular dystrophy 12.09 10.04 8 316614 240 110272437
Listeria encephalitis 12.04 10.04 9 316613 329 110272348
Nasal polyps 12.03 10.04 12 316610 13188 110259489
Corynebacterium infection 12.02 10.04 21 316601 1979 110270698
Septic pulmonary embolism 12.02 10.04 9 316613 330 110272347
Haemorrhage in pregnancy 12.01 10.04 19 316603 1649 110271028
Scleroderma renal crisis 11.99 10.04 14 316608 909 110271768
Mood swings 11.97 10.04 30 316592 22782 110249895
Spinal fusion surgery 11.97 10.04 55 316567 9101 110263576
Ischaemic cardiomyopathy 11.95 10.04 4 316618 8007 110264670
Clonus 11.92 10.04 5 316617 8711 110263966
Metastases to spinal cord 11.88 10.04 8 316614 247 110272430
Pulmonary cavitation 11.86 10.04 22 316600 2172 110270505
Dermatitis allergic 11.85 10.04 28 316594 21696 110250981
Parathyroid disorder 11.85 10.04 12 316610 663 110272014
Erythema 11.85 10.04 698 315924 290749 109981928
Facial paralysis 11.83 10.04 33 316589 24181 110248496
Sinus congestion 11.79 10.04 46 316576 30413 110242264
Non-small cell lung cancer 11.77 10.04 4 316618 7931 110264746
Aortic stenosis 11.75 10.04 12 316610 13047 110259630
Colonic abscess 11.75 10.04 20 316602 1845 110270832
Impetigo 11.75 10.04 24 316598 2544 110270133
Renal cell carcinoma stage III 11.72 10.04 4 316618 24 110272653
Anorectal discomfort 11.70 10.04 32 316590 4094 110268583
Haemorrhage intracranial 11.70 10.04 43 316579 28926 110243751
Granulomatous lymphadenitis 11.65 10.04 10 316612 447 110272230
Meningeal neoplasm 11.64 10.04 5 316617 60 110272617
Influenza 11.64 10.04 382 316240 168719 110103958
Carotid artery stenosis 11.60 10.04 6 316616 9257 110263420
Head discomfort 11.60 10.04 23 316599 18977 110253700
Breast cancer metastatic 11.59 10.04 9 316613 11172 110261505
Liver sarcoidosis 11.58 10.04 4 316618 25 110272652
Laser therapy 11.58 10.04 4 316618 25 110272652
Superimposed pre-eclampsia 11.58 10.04 4 316618 25 110272652
Hypergammaglobulinaemia 11.56 10.04 14 316608 944 110271733
Gallbladder disorder 11.56 10.04 27 316595 21002 110251675
Coronary artery occlusion 11.55 10.04 17 316605 15755 110256922
Gastrointestinal obstruction 11.53 10.04 22 316600 2218 110270459
Intestinal villi atrophy 11.51 10.04 11 316611 566 110272111
Eye swelling 11.49 10.04 52 316570 32996 110239681
Enteritis 11.49 10.04 94 316528 19062 110253615
Acinetobacter infection 11.45 10.04 29 316593 3544 110269133
Hyperbilirubinaemia 11.44 10.04 47 316575 30624 110242053
Chorioretinitis 11.43 10.04 17 316605 1398 110271279
Primary effusion lymphoma 11.42 10.04 5 316617 63 110272614
Biopsy liver abnormal 11.42 10.04 10 316612 459 110272218
Atrial tachycardia 11.42 10.04 6 316616 9172 110263505
Ear infection bacterial 11.42 10.04 8 316614 264 110272413
Bundle branch block right 11.40 10.04 11 316611 12280 110260397
Hiccups 11.38 10.04 12 316610 12857 110259820
Respiration abnormal 11.36 10.04 7 316615 9802 110262875
Oesophagitis 11.35 10.04 43 316579 28672 110244005
Ophthalmic herpes zoster 11.35 10.04 28 316594 3367 110269310
Anaphylactic reaction 11.33 10.04 417 316205 113883 110158794
Drain site complication 11.32 10.04 4 316618 27 110272650
Fluid intake reduced 11.31 10.04 3 316619 6983 110265694
Cryoglobulins present 11.30 10.04 3 316619 6 110272671
Anaplastic large cell lymphoma T- and null-cell types stage III 11.30 10.04 3 316619 6 110272671
Actinic cheilitis 11.30 10.04 3 316619 6 110272671
Isosporiasis 11.29 10.04 7 316615 187 110272490
Gastroenterostomy 11.29 10.04 5 316617 65 110272612
Neurosarcoidosis 11.28 10.04 10 316612 467 110272210
Necrotising retinitis 11.25 10.04 18 316604 1578 110271099
Peripheral sensory neuropathy 11.25 10.04 19 316603 16661 110256016
Polyhydramnios 11.23 10.04 20 316602 1913 110270764
Bullous erysipelas 11.20 10.04 4 316618 28 110272649
Benign prostatic hyperplasia 11.20 10.04 22 316600 18212 110254465
Bacillary angiomatosis 11.19 10.04 9 316613 367 110272310
Burkitt's lymphoma 11.18 10.04 6 316616 121 110272556
Colonoscopy abnormal 11.16 10.04 7 316615 191 110272486
Emphysema 11.15 10.04 25 316597 19731 110252946
Wrong product administered 11.14 10.04 9 316613 10951 110261726
Injection site discomfort 11.12 10.04 3 316619 6904 110265773
Deformity 11.12 10.04 58 316564 10102 110262575
Diverticulum 11.11 10.04 17 316605 15509 110257168
Seasonal allergy 11.10 10.04 25 316597 19697 110252980
Complement factor C3 decreased 11.08 10.04 9 316613 372 110272305
Abscess limb 11.08 10.04 51 316571 8446 110264231
Joint dislocation reduction 11.08 10.04 4 316618 29 110272648
Blood pressure inadequately controlled 11.06 10.04 4 316618 7629 110265048
Hepatic enzyme decreased 11.06 10.04 14 316608 988 110271689
Quality of life decreased 11.05 10.04 74 316548 14095 110258582
Extrasystoles 11.01 10.04 5 316617 8313 110264364
Faecaloma 10.98 10.04 16 316606 14892 110257785
Anastomotic complication 10.98 10.04 11 316611 600 110272077
General physical condition abnormal 10.96 10.04 4 316618 7586 110265091
Product prescribing error 10.96 10.04 94 316528 51237 110221440
Coronary artery stenosis 10.91 10.04 14 316608 13744 110258933
Subretinal fibrosis 10.91 10.04 7 316615 199 110272478
Pathological fracture 10.89 10.04 11 316611 12021 110260656
Stupor 10.89 10.04 5 316617 8260 110264417
Histiocytic necrotising lymphadenitis 10.89 10.04 5 316617 71 110272606
Acarodermatitis 10.88 10.04 20 316602 1961 110270716
Antineutrophil cytoplasmic antibody decreased 10.85 10.04 4 316618 31 110272646
Ureteral neoplasm 10.85 10.04 4 316618 31 110272646
Drug resistance 10.82 10.04 224 316398 56150 110216527
Gastrointestinal oedema 10.81 10.04 27 316595 3271 110269406
Acidosis 10.79 10.04 31 316591 22500 110250177
Hyperparathyroidism secondary 10.78 10.04 27 316595 3277 110269400
Brain oedema 10.77 10.04 49 316573 31049 110241628
Lacrimal haemorrhage 10.74 10.04 4 316618 32 110272645
Congestive cardiomyopathy 10.73 10.04 15 316607 14204 110258473
Middle insomnia 10.73 10.04 27 316595 20475 110252202
Blood magnesium decreased 10.73 10.04 26 316596 19970 110252707
Meningioma malignant 10.71 10.04 5 316617 74 110272603
Pulmonary function test increased 10.70 10.04 3 316619 8 110272669
Joint effusion 10.68 10.04 99 316523 20806 110251871
Cardiac valve vegetation 10.65 10.04 14 316608 1026 110271651
Sciatica 10.64 10.04 343 316279 92056 110180621
Focal segmental glomerulosclerosis 10.63 10.04 31 316591 4114 110268563
Central nervous system function test abnormal 10.63 10.04 4 316618 33 110272644
Enteropathy-associated T-cell lymphoma 10.63 10.04 4 316618 33 110272644
Peripheral artery aneurysm 10.62 10.04 10 316612 505 110272172
Skin striae 10.58 10.04 21 316601 2180 110270497
Anal fissure haemorrhage 10.56 10.04 6 316616 136 110272541
Anovulatory cycle 10.56 10.04 6 316616 136 110272541
Myasthenia gravis 10.55 10.04 101 316521 21410 110251267
Herpes simplex test positive 10.55 10.04 11 316611 629 110272048
Hypercalcaemia 10.53 10.04 190 316432 46467 110226210
Neoplasm malignant 10.51 10.04 157 316465 36986 110235691
Pseudomonas infection 10.49 10.04 124 316498 27729 110244948
Mantle cell lymphoma 10.47 10.04 18 316604 1674 110271003
Skin hyperpigmentation 10.47 10.04 51 316571 8645 110264032
Myelitis transverse 10.47 10.04 22 316600 2379 110270298
Embolic stroke 10.46 10.04 6 316616 8737 110263940
Supraventricular extrasystoles 10.46 10.04 5 316617 8068 110264609
Blood urine present 10.45 10.04 35 316587 24210 110248467
Vascular stenosis 10.44 10.04 12 316610 766 110271911
Brain natriuretic peptide increased 10.43 10.04 10 316612 11199 110261478
Pneumoperitoneum 10.42 10.04 30 316592 3954 110268723
Failed induction of labour 10.41 10.04 8 316614 305 110272372
Tuberous sclerosis complex 10.40 10.04 6 316616 140 110272537
Hepatitis acute 10.39 10.04 24 316598 18742 110253935
Rectal cancer 10.37 10.04 29 316593 3760 110268917
Femoral artery aneurysm 10.34 10.04 7 316615 218 110272459
Cholangitis chronic 10.33 10.04 4 316618 36 110272641
Renal injury 10.30 10.04 24 316598 18689 110253988
Nerve compression 10.29 10.04 10 316612 11127 110261550
Foot fracture 10.26 10.04 38 316584 25508 110247169
Dermatitis contact 10.26 10.04 15 316607 13938 110258739
Herpes zoster meningoencephalitis 10.26 10.04 14 316608 1064 110271613
Leiomyoma 10.24 10.04 9 316613 415 110272262
Cystitis escherichia 10.24 10.04 12 316610 782 110271895
Hepatic vein thrombosis 10.23 10.04 8 316614 313 110272364
Metabolic disorder 10.23 10.04 9 316613 10501 110262176
Osteomyelitis chronic 10.20 10.04 12 316610 785 110271892
Hypoacusis 10.18 10.04 59 316563 35132 110237545
Transfusion 10.16 10.04 38 316584 25434 110247243
Threatened labour 10.16 10.04 11 316611 657 110272020
Lung opacity 10.16 10.04 11 316611 11641 110261036
Ileal perforation 10.16 10.04 16 316606 1384 110271293
Osteosarcoma 10.15 10.04 9 316613 420 110272257
Viral sepsis 10.15 10.04 7 316615 225 110272452
Total bile acids increased 10.14 10.04 5 316617 84 110272593
Infective aortitis 10.14 10.04 5 316617 84 110272593
Laparotomy 10.12 10.04 10 316612 536 110272141
Anastomotic fistula 10.11 10.04 6 316616 148 110272529
Flank pain 10.09 10.04 106 316516 23024 110249653
Hepatitis fulminant 10.07 10.04 6 316616 8554 110264123
Disseminated cryptococcosis 10.06 10.04 23 316599 2634 110270043
Testicular cyst 10.05 10.04 4 316618 39 110272638

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hydrops foetalis 54.71 35.94 17 290 80 113566

Pharmacologic Action:

SourceCodeDescription
ATC L04AX01 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
IMMUNOSUPPRESSANTS
IMMUNOSUPPRESSANTS
Other immunosuppressants
FDA CS M0015066 Nucleosides
FDA CS M0018169 Purines
FDA MoA N0000000233 Nucleic Acid Synthesis Inhibitors
CHEBI has role CHEBI:22587 antiviral agent
CHEBI has role CHEBI:35221 antimetabolite
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:35705 immunosuppressive agent
CHEBI has role CHEBI:35842 antirheumatic drug
CHEBI has role CHEBI:35845 gout suppressant
CHEBI has role CHEBI:50177 dermatologic drug
CHEBI has role CHEBI:50266 prodrug
CHEBI has role CHEBI:50903 carcinogenic agent
CHEBI has role CHEBI:50908 hepatotoxic agent
CHEBI has role CHEBI:59517 DNA synthesis inhibitor
CHEBI has role CHEBI:67079 anti-inflammatory agent
CHEBI has role CHEBI:75835 anti-anaemic agent
CHEBI has role CHEBI:231911 renoprotective agent
CHEBI has role CHEBI:233423 antifibrotic agent
MeSH PA D000963 Antimetabolites
MeSH PA D000964 Antimetabolites, Antineoplastic
MeSH PA D000970 Antineoplastic Agents
MeSH PA D007155 Immunologic Factors
MeSH PA D007166 Immunosuppressive Agents
MeSH PA D018501 Antirheumatic Agents
FDA EPC N0000175712 Purine Antimetabolite

Related Drugs by ATC class:

L04AX Other immunosuppressants 8 drugs
dimethyl fumaratediroximel fumaratelenalidomidemethotrexatepirfenidonepomalidomidetegomil fumaratethalidomide

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Refractory idiopathic thrombocytopenic purpura indication 13172003
Relapsing multiple sclerosis indication 24700007 DOID:2377
Crohn's disease indication 34000006
Pemphigus vulgaris indication 49420001 DOID:0060851
Systemic lupus erythematosus indication 55464009 DOID:9074
Ulcerative colitis indication 64766004 DOID:8577
Rheumatoid arthritis indication 69896004 DOID:7148
Bullous pemphigoid indication 77090002 DOID:8506
Myasthenia gravis indication 91637004 DOID:437
Polyarteritis nodosa indication 155441006 DOID:9810
Behcet's disease indication 310701003 DOID:13241
Dermatomyositis indication 396230008 DOID:10223
Autoimmune hepatitis indication 408335007
Refractory autoimmune haemolytic anaemia indication 413603009 DOID:718
Prevention of Kidney Transplant Rejection indication
Polymyositis off-label use 31384009
Prevention of Lung Transplant Rejection off-label use
Prevention of Cardiac Transplant Rejection off-label use
Prevention of Liver Transplant Rejection off-label use
Mycosis contraindication 3218000 DOID:1564
Viral disease contraindication 34014006 DOID:934
Hepatic vein thrombosis contraindication 38739001 DOID:11512
Bacterial infectious disease contraindication 87628006
Malignant lymphoma contraindication 118600007 DOID:0060058
Liver function tests abnormal contraindication 166603001
Acute pancreatitis contraindication 197456007 DOID:2913
Impaired renal function disorder contraindication 197663003
Anemia contraindication 271737000 DOID:2355
Pregnancy, function contraindication 289908002
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Bone marrow depression contraindication 307762000
Hepatosplenic T-cell lymphoma contraindication 445406001
Thiopurine S-Methyltransferase Deficiency contraindication
Severe Leukopenia contraindication
Protozoal Infection contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.28 acidic
pKa2 3.24 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
ATP-binding cassette sub-family G member 2 Transporter WOMBAT-PK
Multidrug resistance-associated protein 5 Transporter WOMBAT-PK
Multidrug resistance-associated protein 4 Transporter WOMBAT-PK
Ras-related C3 botulinum toxin substrate 1 Enzyme WOMBAT-PK
Thiopurine S-methyltransferase Enzyme WOMBAT-PK

External reference:

IDSource
4018766 VUID
N0000147069 NUI
D00238 KEGG_DRUG
1256 RXNORM
C0004482 UMLSCUI
CHEMBL1542 ChEMBL_ID
DB00993 DRUGBANK_ID
CHEMBL1200400 ChEMBL_ID
D001379 MESH_DESCRIPTOR_UI
2265 PUBCHEM_CID
7120 IUPHAR_LIGAND_ID
1291 INN_ID
55774-33-9 SECONDARY_CAS_RN
MRK240IY2L UNII
3341 MMSL
4234 MMSL
4235 MMSL
6041 MMSL
d00024 MMSL
4018766 VANDF
003419 NDDF
004123 NDDF
111165009 SNOMEDCT_US
372574004 SNOMEDCT_US
67221004 SNOMEDCT_US
MRK240IY2L INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Azathioprine Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0143-9566 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 100 mg INTRAVENOUS ANDA 23 sections
AZATHIOPRINE Human Prescription Drug Label 1 16571-835 TABLET 50 mg ORAL ANDA 19 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 21695-484 TABLET 50 mg ORAL ANDA 20 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 33261-758 TABLET 50 mg ORAL ANDA 20 sections
AZATHIOPRINE HUMAN PRESCRIPTION DRUG LABEL 1 42291-063 TABLET 100 mg ORAL ANDA 19 sections
AZATHIOPRINE HUMAN PRESCRIPTION DRUG LABEL 1 42291-071 TABLET 50 mg ORAL ANDA 19 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 43353-745 TABLET 50 mg ORAL ANDA 23 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 51407-182 TABLET 50 mg ORAL ANDA 14 sections
IMURAN HUMAN PRESCRIPTION DRUG LABEL 1 54766-590 TABLET 50 mg ORAL NDA 23 sections
IMURAN HUMAN PRESCRIPTION DRUG LABEL 1 54766-590 TABLET 50 mg ORAL NDA 23 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 54868-5310 TABLET 50 mg ORAL ANDA 20 sections
AZATHIOPRINE HUMAN PRESCRIPTION DRUG LABEL 1 60219-1076 TABLET 50 mg ORAL ANDA 19 sections
AZATHIOPRINE HUMAN PRESCRIPTION DRUG LABEL 1 60219-2036 TABLET 75 mg ORAL ANDA 19 sections
AZATHIOPRINE HUMAN PRESCRIPTION DRUG LABEL 1 60219-2037 TABLET 100 mg ORAL ANDA 19 sections
IMURAN HUMAN PRESCRIPTION DRUG LABEL 1 65483-590 TABLET 50 mg ORAL NDA 23 sections
Azasan HUMAN PRESCRIPTION DRUG LABEL 1 65649-231 TABLET 75 mg ORAL ANDA 13 sections
Azasan HUMAN PRESCRIPTION DRUG LABEL 1 65649-241 TABLET 100 mg ORAL ANDA 13 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 65841-602 TABLET 50 mg ORAL ANDA 1 sections
Azathioprine Human Prescription Drug Label 1 67877-492 TABLET 25 mg ORAL ANDA 21 sections
Azathioprine Human Prescription Drug Label 1 67877-493 TABLET 50 mg ORAL ANDA 21 sections
Azathioprine Human Prescription Drug Label 1 67877-494 TABLET 75 mg ORAL ANDA 21 sections
Azathioprine Human Prescription Drug Label 1 67877-495 TABLET 100 mg ORAL ANDA 21 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 68071-3772 TABLET 50 mg ORAL ANDA 20 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 68071-3997 TABLET 50 mg ORAL ANDA 21 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 68084-229 TABLET 50 mg ORAL ANDA 21 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 68382-003 TABLET 50 mg ORAL ANDA 20 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 68382-118 TABLET 25 mg ORAL ANDA 20 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 68382-118 TABLET 25 mg ORAL ANDA 20 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 68382-119 TABLET 75 mg ORAL ANDA 20 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 68382-119 TABLET 75 mg ORAL ANDA 20 sections