azathioprine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
269 446-86-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • BW 57-322
  • azathioprine sulfate
  • azathioprine
  • azamune
  • azanin
  • azathioprin
  • azathropine
  • azothioprine
  • azathioprine sodium
Azathioprine is an inactive pro-drug of 6-mercaptopurine (6-MP), which acts as a purine antagonist but requires cellular uptake and intracellular anabolism to thioguanine nucleotides (TGNs) for immunosuppression. TGNs and other metabolites (e.g. 6-methylmercaptopurine ribonucleotides) inhibit de novo purine synthesis and purine nucleotide interconversions. The TGNs are also incorporated into nucleic acids and this contributes to the immunosuppressive effects of the medicinal product. Other potential mechanisms of azathioprine include the inhibition of many pathways in nucleic acid biosynthesis, hence preventing proliferation and activity of cells involved in the immune response (B and T lymphocytes). Because of these mechanisms, the therapeutic effect of azathioprine may be evident only after several weeks or months of treatment. Unlike 6-MP, the activity of the azathioprine metabolite 1-methyl-4-nitro-5-thioimidazole has not been clearly determined. However, compared with 6-MP it appears to modify the activity of azathioprine in several systems. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
  • Molecular weight: 277.26
  • Formula: C9H7N7O2S
  • CLOGP: 0.51
  • LIPINSKI: 0
  • HAC: 9
  • HDO: 1
  • TPSA: 115.42
  • ALOGS: -2.41
  • ROTB: 3
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.15 g O
0.15 g P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 10 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 1 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 18.03 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 60 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

DateAgencyCompanyOrphan
March 20, 1968 FDA PROMETHEUS LABS
Feb. 21, 2019 PMDA ASPEN JAPAN K.K.; MITSUBISHI TANABE PHARMA CORPORATION

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 609.46 9.85 3320 107977 813925 52423844
Blood iron abnormal 547.51 9.85 220 111077 3107 53234662
Off label use 528.80 9.85 2162 109135 470050 52767719
Colitis ulcerative 514.76 9.85 394 110903 20667 53217102
Exposure during pregnancy 507.14 9.85 923 110374 123937 53113832
Drug intolerance 429.82 9.85 1164 110133 204329 53033440
Treatment failure 338.95 9.85 795 110502 127608 53110161
Crohn's disease 260.20 9.85 167 111130 6583 53231186
Product use in unapproved indication 243.29 9.85 645 110652 111644 53126125
Premature delivery 239.73 9.85 284 111013 25820 53211949
Death 232.20 9.85 242 111055 356990 52880779
Cytomegalovirus infection 224.66 9.85 239 111058 19300 53218469
Intestinal stenosis 222.55 9.85 110 111187 2591 53235178
Rheumatoid arthritis 209.48 9.85 1244 110053 313287 52924482
Cushingoid 192.40 9.85 142 111155 7040 53230729
Fall 189.80 9.85 284 111013 358156 52879613
Fistula 176.22 9.85 147 111150 8723 53229046
Lupus-like syndrome 175.46 9.85 149 111148 9063 53228706
Demyelination 168.80 9.85 124 111173 6103 53231666
SLE arthritis 167.60 9.85 60 111237 603 53237166
Bone erosion 166.10 9.85 157 111140 10995 53226774
Anal fistula 164.75 9.85 92 111205 2799 53234970
Ileal stenosis 164.70 9.85 75 111222 1461 53236308
Condition aggravated 161.18 9.85 1116 110181 296018 52941751
Fatigue 157.11 9.85 890 110407 729616 52508153
Drug level below therapeutic 155.47 9.85 97 111200 3636 53234133
Premature labour 150.65 9.85 156 111141 12206 53225563
Post transplant lymphoproliferative disorder 148.64 9.85 100 111197 4271 53233498
Therapeutic response decreased 138.01 9.85 306 110991 47263 53190506
Proteinuria 134.54 9.85 177 111120 17891 53219878
Frequent bowel movements 134.29 9.85 158 111139 14254 53223515
Elbow deformity 133.05 9.85 63 111234 1346 53236423
Maternal exposure during pregnancy 131.95 9.85 658 110639 154981 53082788
Disease recurrence 131.57 9.85 189 111108 20757 53217012
Cholestasis of pregnancy 129.53 9.85 59 111238 1150 53236619
Epstein-Barr virus infection 129.17 9.85 114 111183 7304 53230465
Therapeutic product effect incomplete 128.87 9.85 453 110844 91331 53146438
Intestinal resection 128.56 9.85 73 111224 2295 53235474
Large intestinal stenosis 126.14 9.85 66 111231 1758 53236011
Hyponatraemia 122.69 9.85 37 111260 108570 53129199
Transplant rejection 118.15 9.85 125 111172 10026 53227743
Faecal calprotectin increased 117.18 9.85 66 111231 2042 53235727
Lupus nephritis 117.04 9.85 70 111227 2429 53235340
Product dose omission issue 114.23 9.85 139 111158 191481 53046288
Intentional product use issue 112.47 9.85 370 110927 72124 53165645
Vasculitis 112.23 9.85 147 111150 14793 53222976
Glossodynia 111.78 9.85 35 111262 100256 53137513
Abortion spontaneous 109.22 9.85 276 111021 46359 53191410
Somnolence 108.32 9.85 114 111183 167620 53070149
Confusional state 107.42 9.85 149 111148 194072 53043697
Kidney transplant rejection 107.18 9.85 81 111216 4163 53233606
Impaired gastric emptying 106.40 9.85 112 111185 8931 53228838
Anal abscess 103.72 9.85 77 111220 3851 53233918
Toxicity to various agents 103.00 9.85 188 111109 219410 53018359
Arthritis 102.63 9.85 407 110890 86891 53150878
Malignant neoplasm progression 102.20 9.85 14 111283 71527 53166242
Product use issue 101.69 9.85 566 110731 139018 53098751
Pre-eclampsia 99.79 9.85 106 111191 8541 53229228
Therapeutic product effect decreased 97.93 9.85 519 110778 125136 53112633
Pain 97.04 9.85 775 110522 587623 52650146
Haemophagocytic lymphohistiocytosis 94.97 9.85 106 111191 9031 53228738
Haematochezia 93.32 9.85 245 111052 42113 53195656
Drug abuse 90.87 9.85 14 111283 65512 53172257
Abscess 89.73 9.85 133 111164 15023 53222746
Overdose 88.32 9.85 58 111239 107678 53130091
Hypotension 88.08 9.85 256 111041 253820 52983949
Antinuclear antibody positive 87.64 9.85 88 111209 6637 53231132
Atrial fibrillation 86.38 9.85 64 111233 111588 53126181
Cerebrovascular accident 85.70 9.85 57 111240 105117 53132652
Ankylosing spondylitis 84.00 9.85 94 111203 8031 53229738
Dizziness 83.74 9.85 446 110851 371813 52865956
Inflammation 83.63 9.85 286 111011 56850 53180919
Electrocardiogram QT prolonged 83.07 9.85 10 111287 56393 53181376
Constipation 82.62 9.85 182 111115 198230 53039539
Lung transplant rejection 81.94 9.85 38 111259 773 53236996
Cardiac failure congestive 81.52 9.85 46 111251 92711 53145058
Drug hypersensitivity 80.23 9.85 876 110421 264366 52973403
Abdominal pain 79.65 9.85 850 110447 255053 52982716
Hepatic cirrhosis 79.09 9.85 138 111159 17884 53219885
Cytomegalovirus viraemia 77.66 9.85 72 111225 4919 53232850
Granulomatosis with polyangiitis 77.47 9.85 50 111247 1989 53235780
Squamous cell carcinoma 77.17 9.85 90 111207 8042 53229727
Pleuritic pain 76.87 9.85 83 111214 6813 53230956
Pancreatitis 76.53 9.85 241 111056 45901 53191868
Diffuse large B-cell lymphoma 76.07 9.85 81 111216 6544 53231225
Gestational hypertension 76.05 9.85 52 111245 2281 53235488
Pancytopenia 75.97 9.85 383 110914 90545 53147224
Red blood cell sedimentation rate increased 75.25 9.85 175 111122 27882 53209887
Hepatosplenic T-cell lymphoma 74.63 9.85 33 111264 598 53237171
Osteoporosis 74.63 9.85 240 111057 46220 53191549
Anaphylactic reaction 74.31 9.85 279 111018 58047 53179722
Disseminated tuberculosis 73.33 9.85 55 111242 2794 53234975
Nonalcoholic fatty liver disease 72.80 9.85 38 111259 1007 53236762
Leukopenia 72.69 9.85 325 110972 73138 53164631
Basal cell carcinoma 72.63 9.85 155 111142 23314 53214455
Normal newborn 72.42 9.85 82 111215 7097 53230672
Autoimmune hepatitis 72.25 9.85 88 111209 8230 53229539
Arthralgia 72.24 9.85 1303 109994 438480 52799289
Diarrhoea haemorrhagic 72.23 9.85 88 111209 8232 53229537
Tremor 71.97 9.85 94 111203 125642 53112127
Asthenia 71.62 9.85 422 110875 343168 52894601
Exostosis 71.62 9.85 103 111194 11321 53226448
Rheumatoid nodule 71.52 9.85 105 111192 11759 53226010
Joint dislocation 71.18 9.85 107 111190 12238 53225531
Gastrointestinal inflammation 69.59 9.85 66 111231 4640 53233129
Intestinal obstruction 69.27 9.85 172 111125 28569 53209200
Decreased appetite 69.20 9.85 224 111073 214750 53023019
Anti-neutrophil cytoplasmic antibody positive vasculitis 68.69 9.85 49 111248 2302 53235467
Hair follicle tumour benign 68.58 9.85 27 111270 360 53237409
Progressive multifocal leukoencephalopathy 68.33 9.85 104 111193 12025 53225744
Epstein-Barr virus associated lymphoproliferative disorder 68.08 9.85 43 111254 1647 53236122
Hypokalaemia 67.60 9.85 61 111236 96456 53141313
Synovial fluid analysis 67.39 9.85 43 111254 1677 53236092
Scleritis 67.25 9.85 56 111241 3314 53234455
Anxiety 66.82 9.85 200 111097 196504 53041265
Premature baby 66.22 9.85 135 111162 19666 53218103
Pneumocystis jirovecii pneumonia 66.21 9.85 121 111176 16257 53221512
Tenosynovitis stenosans 64.91 9.85 47 111250 2261 53235508
Liver function test increased 64.86 9.85 160 111137 26468 53211301
Joint stiffness 64.50 9.85 173 111124 30110 53207659
Colectomy 63.14 9.85 45 111252 2111 53235658
Clostridium difficile infection 63.14 9.85 163 111134 27730 53210039
Cardio-respiratory arrest 62.84 9.85 22 111275 58736 53179033
Lymphopenia 62.56 9.85 120 111177 16723 53221046
Insomnia 61.55 9.85 193 111104 186879 53050890
Hand deformity 61.38 9.85 52 111245 84797 53152972
Gastrointestinal lymphoma 60.71 9.85 16 111281 48 53237721
Syncope 59.81 9.85 88 111209 111905 53125864
Immunosuppressant drug level decreased 59.69 9.85 33 111264 984 53236785
Febrile neutropenia 59.49 9.85 79 111218 104857 53132912
Swelling 58.84 9.85 203 111094 190902 53046867
Loss of consciousness 58.82 9.85 92 111205 114120 53123649
Pemphigus 58.28 9.85 79 111218 103952 53133817
Overlap syndrome 58.22 9.85 28 111269 620 53237149
Neuromyelitis optica spectrum disorder 56.96 9.85 32 111265 985 53236784
Blood pressure fluctuation 56.75 9.85 183 111114 35287 53202482
C-reactive protein abnormal 56.32 9.85 149 111148 25721 53212048
Abdominal discomfort 55.87 9.85 254 111043 220808 53016961
Erythema nodosum 55.41 9.85 55 111242 4090 53233679
Histoplasmosis disseminated 55.15 9.85 34 111263 1247 53236522
Pulmonary mass 55.00 9.85 126 111171 19878 53217891
C-reactive protein increased 54.63 9.85 283 111014 67603 53170166
Hallucination 54.49 9.85 22 111275 53816 53183953
Lymphoproliferative disorder 54.41 9.85 47 111250 2925 53234844
Joint swelling 54.36 9.85 737 110560 233901 53003868
Caesarean section 54.30 9.85 115 111182 17205 53220564
Hypogammaglobulinaemia 54.17 9.85 65 111232 5985 53231784
Interstitial lung disease 54.02 9.85 254 111043 58368 53179401
Diabetes mellitus 53.72 9.85 239 111058 53660 53184109
Cardiac arrest 53.62 9.85 70 111227 93597 53144172
Dyspnoea 53.23 9.85 882 110415 585350 52652419
Contusion 52.57 9.85 94 111203 110638 53127131
Lupus vasculitis 52.54 9.85 24 111273 471 53237298
Tuberculosis 51.50 9.85 87 111210 10984 53226785
Neutrophil count decreased 51.45 9.85 19 111278 49079 53188690
Discomfort 50.99 9.85 75 111222 95397 53142372
Agitation 50.18 9.85 30 111267 58596 53179173
Stomatitis 49.66 9.85 80 111217 98078 53139691
Pulmonary tuberculosis 49.65 9.85 56 111241 4825 53232944
Depression 48.87 9.85 206 111091 182846 53054923
Seizure 48.16 9.85 126 111171 129383 53108386
Plasma cell myeloma 47.74 9.85 20 111277 47854 53189915
Ulcer 47.19 9.85 121 111176 20498 53217271
Intestinal fistula 47.10 9.85 26 111271 773 53236996
Listeriosis 46.98 9.85 32 111265 1395 53236374
Drug level decreased 46.81 9.85 64 111233 6710 53231059
Angiocentric lymphoma 45.87 9.85 23 111274 559 53237210
Premature separation of placenta 45.75 9.85 35 111262 1832 53235937
Chronic allograft nephropathy 45.27 9.85 24 111273 657 53237112
Wound 45.03 9.85 76 111221 91481 53146288
Epstein-Barr virus test positive 44.81 9.85 23 111274 588 53237181
Neoplasm progression 44.81 9.85 5 111292 29914 53207855
Sedation 44.34 9.85 5 111292 29670 53208099
Histoplasmosis 44.04 9.85 34 111263 1804 53235965
Female genital tract fistula 43.76 9.85 48 111249 4010 53233759
Foot deformity 43.57 9.85 110 111187 18458 53219311
Anal fissure 43.56 9.85 42 111255 3014 53234755
Impaired work ability 43.53 9.85 93 111204 13997 53223772
Feeling abnormal 43.49 9.85 141 111156 135160 53102609
Cytomegalovirus colitis 43.46 9.85 35 111262 1975 53235794
Platelet count decreased 43.46 9.85 101 111196 107998 53129771
Therapeutic product effect variable 43.36 9.85 29 111268 1226 53236543
Central nervous system lymphoma 43.26 9.85 31 111266 1467 53236302
Blood glucose increased 43.07 9.85 59 111238 77302 53160467
Nicotinic acid deficiency 42.88 9.85 12 111285 48 53237721
Immunosuppressant drug level increased 42.81 9.85 44 111253 3411 53234358
B-cell lymphoma 42.73 9.85 44 111253 3419 53234350
Osteonecrosis 42.41 9.85 137 111160 26438 53211331
Cholangitis sclerosing 42.31 9.85 28 111269 1163 53236606
Muscle injury 42.09 9.85 6 111291 29760 53208009
Hyperkalaemia 42.07 9.85 31 111266 54225 53183544
Intentional overdose 41.87 9.85 47 111250 67158 53170611
Balance disorder 41.60 9.85 55 111242 73152 53164617
Back pain 41.49 9.85 302 110995 233945 53003824
Suicidal ideation 41.46 9.85 39 111258 60472 53177297
Mycobacterial infection 41.36 9.85 32 111265 1703 53236066
Papilloma viral infection 41.21 9.85 29 111268 1333 53236436
Dehydration 41.05 9.85 196 111101 168214 53069555
Coma 40.97 9.85 41 111256 61742 53176027
Phospholipidosis 40.88 9.85 12 111285 59 53237710
Pulmonary fibrosis 40.88 9.85 127 111170 24008 53213761
Clear cell renal cell carcinoma 40.74 9.85 27 111270 1124 53236645
Injection site swelling 40.63 9.85 19 111278 42609 53195160
Depressed level of consciousness 39.80 9.85 33 111264 54395 53183374
Subcutaneous abscess 39.77 9.85 52 111245 5222 53232547
Bradycardia 39.75 9.85 54 111243 71002 53166767
Product label confusion 39.74 9.85 20 111277 490 53237279
Bronchiectasis 39.59 9.85 76 111221 10596 53227173
Foetal exposure during pregnancy 39.28 9.85 160 111137 34555 53203214
Foetal death 38.98 9.85 70 111227 9277 53228492
Muscle fatigue 38.92 9.85 35 111262 2298 53235471
Antiphospholipid syndrome 38.72 9.85 31 111266 1735 53236034
Epicondylitis 38.68 9.85 33 111264 2019 53235750
Small intestinal obstruction 38.59 9.85 100 111197 17047 53220722
Myasthenia gravis 38.29 9.85 44 111253 3869 53233900
Foetal growth restriction 38.29 9.85 60 111237 7114 53230655
Nausea 38.28 9.85 1245 110052 754846 52482923
Renal impairment 38.17 9.85 301 110996 83017 53154752
Premature rupture of membranes 37.71 9.85 49 111248 4891 53232878
Fungal endocarditis 37.55 9.85 16 111281 264 53237505
Pregnancy 37.25 9.85 147 111150 31294 53206475
Squamous cell carcinoma of skin 37.24 9.85 51 111246 5356 53232413
Injection site erythema 37.18 9.85 65 111232 77184 53160585
Injection site inflammation 37.09 9.85 40 111257 3278 53234491
Hypoglycaemia 37.06 9.85 41 111256 58972 53178797
Immunosuppression 36.96 9.85 62 111235 7782 53229987
Red blood cell sedimentation rate abnormal 36.87 9.85 93 111204 15596 53222173
Respiratory arrest 36.83 9.85 12 111285 33528 53204241
Colitis 36.79 9.85 178 111119 41374 53196395
Bone pain 36.78 9.85 31 111266 50691 53187078
Bone marrow failure 36.65 9.85 142 111155 29973 53207796
Disseminated cytomegaloviral infection 36.30 9.85 14 111283 176 53237593
Full blood count decreased 36.03 9.85 4 111293 24025 53213744
Intestinal fibrosis 36.02 9.85 13 111284 134 53237635
Dermatomyositis 35.91 9.85 34 111263 2385 53235384
Abdominal adhesions 35.87 9.85 38 111259 3052 53234717
Serotonin syndrome 35.80 9.85 6 111291 26400 53211369
Ileostomy 35.74 9.85 25 111272 1138 53236631
Orthostatic hypotension 35.70 9.85 9 111288 29744 53208025
Metabolic acidosis 35.62 9.85 22 111275 42220 53195549
Chronic obstructive pulmonary disease 35.61 9.85 45 111252 61028 53176741
Enterocutaneous fistula 35.41 9.85 26 111271 1278 53236491
Wrong technique in product usage process 35.24 9.85 44 111253 59988 53177781
Low birth weight baby 35.22 9.85 54 111243 6283 53231486
Pneumonia cytomegaloviral 35.09 9.85 32 111265 2140 53235629
Crepitations 35.03 9.85 56 111241 6753 53231016
Nephrotic syndrome 34.69 9.85 49 111248 5296 53232473
Inflammatory bowel disease 34.54 9.85 41 111256 3732 53234037
Drug specific antibody present 34.40 9.85 39 111258 3379 53234390
Secondary immunodeficiency 34.34 9.85 24 111273 1091 53236678
Musculoskeletal stiffness 34.29 9.85 401 110896 122967 53114802
Chorioretinopathy 34.18 9.85 22 111275 871 53236898
Infusion related reaction 34.10 9.85 485 110812 155472 53082297
Palmar-plantar erythrodysaesthesia syndrome 33.95 9.85 3 111294 21603 53216166
Intentional self-injury 33.72 9.85 6 111291 25278 53212491
Intentional product misuse 33.64 9.85 32 111265 49360 53188409
White blood cell count decreased 33.25 9.85 140 111157 124335 53113434
Liver transplant rejection 33.10 9.85 26 111271 1415 53236354
Proctitis 33.04 9.85 30 111267 1995 53235774
Nodular regenerative hyperplasia 32.40 9.85 15 111282 304 53237465
Dyskinesia 32.22 9.85 13 111284 31820 53205949
Plasmablastic lymphoma 32.00 9.85 14 111283 247 53237522
Panniculitis 31.92 9.85 58 111239 7756 53230013
Mycobacterium abscessus infection 31.85 9.85 19 111278 656 53237113
Suicide attempt 31.74 9.85 45 111252 58123 53179646
Renal mass 31.63 9.85 29 111268 1953 53235816
Duodenal ulcer perforation 31.55 9.85 17 111280 35166 53202603
Neuropathy peripheral 31.46 9.85 110 111187 103077 53134692
Injury 31.37 9.85 36 111261 50935 53186834
Heart transplant rejection 31.27 9.85 17 111280 490 53237279
Irritable bowel syndrome 31.23 9.85 27 111270 43605 53194164
Live birth 31.03 9.85 85 111212 14974 53222795
Trichodysplasia spinulosa 30.96 9.85 17 111280 500 53237269
Adverse reaction 30.91 9.85 62 111235 8925 53228844
Drug withdrawal syndrome 30.81 9.85 10 111287 28012 53209757
Headache 30.77 9.85 869 110428 535952 52701817
Natural killer-cell leukaemia 30.60 9.85 11 111286 112 53237657
Pyoderma gangrenosum 30.58 9.85 35 111262 3064 53234705
Salmonellosis 30.49 9.85 21 111276 932 53236837
Acute kidney injury 30.38 9.85 361 110936 253507 52984262
Retinitis 30.30 9.85 23 111274 1190 53236579
Product quality issue 30.23 9.85 20 111277 37003 53200766
Rhegmatogenous retinal detachment 30.16 9.85 10 111287 78 53237691
Synovitis 30.11 9.85 351 110946 107542 53130227
Rectal abscess 29.95 9.85 22 111275 1082 53236687
Complications of bone marrow transplant 29.92 9.85 16 111281 446 53237323
Injection site bruising 29.85 9.85 21 111276 37625 53200144
Bronchitis 29.80 9.85 126 111171 111773 53125996
Blister 29.74 9.85 76 111221 78677 53159092
Drug ineffective for unapproved indication 29.68 9.85 103 111194 20617 53217152
Hyperhidrosis 29.64 9.85 103 111194 96690 53141079
Jaw fracture 29.55 9.85 32 111265 2635 53235134
Coombs positive haemolytic anaemia 29.53 9.85 15 111282 375 53237394
Eye infection toxoplasmal 29.44 9.85 14 111283 302 53237467
Scleroderma renal crisis 29.36 9.85 14 111283 304 53237465
Mycobacterium avium complex infection 29.34 9.85 33 111264 2835 53234934
Lactic acidosis 29.25 9.85 21 111276 37232 53200537
Restlessness 29.21 9.85 11 111286 28076 53209693
Cervical dysplasia 29.07 9.85 34 111263 3047 53234722
Extrapulmonary tuberculosis 28.94 9.85 14 111283 314 53237455
Varicella zoster virus infection 28.83 9.85 31 111266 2532 53235237
Fluid retention 28.78 9.85 43 111254 54358 53183411
Synovial cyst 28.78 9.85 58 111239 8378 53229391
Meningitis cryptococcal 28.71 9.85 23 111274 1288 53236481
Device dislocation 28.58 9.85 7 111290 23590 53214179
Myositis 28.55 9.85 58 111239 8425 53229344
Laryngeal disorder 28.54 9.85 20 111277 913 53236856
Rectal cancer metastatic 28.42 9.85 13 111284 256 53237513
Multiple sclerosis relapse 28.34 9.85 31 111266 44822 53192947
Ganglioneuroma 28.33 9.85 11 111286 141 53237628
Herpes simplex hepatitis 28.31 9.85 14 111283 330 53237439
Neoplasm malignant 28.18 9.85 117 111180 25484 53212285
Therapeutic reaction time decreased 28.16 9.85 23 111274 1324 53236445
Uveitis 27.91 9.85 62 111235 9582 53228187
Episcleritis 27.84 9.85 19 111278 831 53236938
Antisynthetase syndrome 27.63 9.85 9 111288 66 53237703
Folliculitis 27.45 9.85 16 111281 31693 53206076
Hepatic fibrosis 27.41 9.85 34 111263 3239 53234530
Aspergillus infection 27.34 9.85 53 111244 7443 53230326
Cardiac failure 27.20 9.85 90 111207 85754 53152015
Joint effusion 27.15 9.85 75 111222 13277 53224492
Contraindicated product administered 26.98 9.85 415 110882 135214 53102555
Kaposi's sarcoma 26.89 9.85 11 111286 163 53237606
Accidental exposure to product 26.83 9.85 8 111289 23666 53214103
Abdominal abscess 26.81 9.85 39 111258 4331 53233438
Anogenital warts 26.72 9.85 15 111282 461 53237308
Antinuclear antibody negative 26.62 9.85 12 111285 228 53237541
Mental status changes 26.53 9.85 26 111271 39545 53198224
Tractional retinal detachment 26.51 9.85 8 111289 44 53237725
Klebsiella infection 26.45 9.85 54 111243 7872 53229897
Abscess intestinal 26.41 9.85 23 111274 1447 53236322
Colectomy total 26.27 9.85 10 111287 121 53237648
Inappropriate schedule of product administration 26.22 9.85 255 111042 74623 53163146
Thiopurine methyltransferase decreased 26.04 9.85 13 111284 313 53237456
Congenital osteodystrophy 25.86 9.85 7 111290 24 53237745
Aphthous ulcer 25.79 9.85 65 111232 10893 53226876
Myocardial infarction 25.76 9.85 113 111184 99241 53138528
Somatic delusion 25.73 9.85 16 111281 596 53237173
Emotional distress 25.66 9.85 18 111279 32299 53205470
Drug tolerance decreased 25.59 9.85 51 111246 7307 53230462
Eosinophilic granulomatosis with polyangiitis 25.45 9.85 27 111270 2172 53235597
Drug tolerance 25.41 9.85 38 111259 4325 53233444
Bursitis infective 25.18 9.85 21 111276 1245 53236524
Strongyloidiasis 25.15 9.85 19 111278 976 53236793
Glomerulosclerosis 24.99 9.85 13 111284 342 53237427
Encephalopathy 24.89 9.85 24 111273 36784 53200985
Oedema peripheral 24.83 9.85 232 111065 170555 53067214
Pneumonia aspiration 24.82 9.85 21 111276 34280 53203489
Asthma 24.72 9.85 130 111167 108842 53128927
Ileectomy 24.70 9.85 10 111287 144 53237625
Helicobacter infection 24.69 9.85 27 111270 39042 53198727
Abscess rupture 24.65 9.85 12 111285 273 53237496
Intestinal mucosal hypertrophy 24.45 9.85 11 111286 208 53237561
Wrist deformity 24.38 9.85 24 111273 1767 53236002
Meningoencephalitis viral 24.09 9.85 13 111284 369 53237400
Myelosuppression 24.08 9.85 70 111227 12758 53225011
Anal cancer 24.01 9.85 14 111283 463 53237306
Rectal discharge 24.01 9.85 14 111283 463 53237306
Cardiac disorder 24.00 9.85 38 111259 46928 53190841
Tuberculosis of central nervous system 24.00 9.85 13 111284 372 53237397
Varicella 23.95 9.85 24 111273 1805 53235964
Intestinal anastomosis 23.88 9.85 12 111285 293 53237476
Urinary retention 23.76 9.85 15 111282 28451 53209318
Hypomagnesaemia 23.73 9.85 11 111286 24800 53212969
Renal transplant failure 23.72 9.85 16 111281 686 53237083
Dysgeusia 23.63 9.85 33 111264 42898 53194871
Infectious mononucleosis 23.63 9.85 23 111274 1670 53236099
Vomiting 23.55 9.85 825 110472 496314 52741455
Unresponsive to stimuli 23.54 9.85 21 111276 33405 53204364
Impaired healing 23.45 9.85 63 111234 64142 53173627
HELLP syndrome 23.27 9.85 18 111279 958 53236811
Serum sickness 23.10 9.85 28 111269 2605 53235164
External auditory canal atresia 22.93 9.85 8 111289 74 53237695
Gastrointestinal stoma output abnormal 22.69 9.85 7 111290 42 53237727
Disturbance in attention 22.58 9.85 23 111274 34360 53203409
Aplasia pure red cell 22.56 9.85 37 111260 4559 53233210
Small intestinal stenosis 22.55 9.85 14 111283 520 53237249
Oesophageal squamous cell carcinoma 22.53 9.85 9 111288 125 53237644
Proctalgia 22.52 9.85 40 111257 5256 53232513
Atypical haemolytic uraemic syndrome 22.38 9.85 14 111283 527 53237242
Sopor 22.36 9.85 8 111289 21076 53216693
Corynebacterium infection 22.35 9.85 13 111284 428 53237341
Flank pain 22.19 9.85 72 111225 13924 53223845
Porokeratosis 22.14 9.85 9 111288 131 53237638
Sleep disorder 22.08 9.85 57 111240 58813 53178956
Appendicitis 22.05 9.85 46 111251 6808 53230961
Conjunctivitis 22.05 9.85 82 111215 16975 53220794
Abdominal pain upper 22.04 9.85 231 111066 166060 53071709
Disorientation 21.92 9.85 30 111267 39329 53198440
Small intestine carcinoma 21.76 9.85 12 111285 356 53237413
Hydrops foetalis 21.70 9.85 12 111285 358 53237411
Delirium 21.67 9.85 33 111264 41396 53196373
Gastrointestinal haemorrhage 21.66 9.85 90 111207 80240 53157529
Renal tubular atrophy 21.64 9.85 14 111283 559 53237210
Central nervous system vasculitis 21.60 9.85 17 111280 928 53236841
Lipase increased 21.42 9.85 55 111242 9323 53228446
Accidental overdose 21.37 9.85 9 111288 21470 53216299
Herpes simplex reactivation 21.34 9.85 12 111285 370 53237399
Lymphadenopathy 21.24 9.85 139 111158 36116 53201653
Skin lesion 21.21 9.85 117 111180 28612 53209157
Therapeutic response shortened 21.21 9.85 46 111251 6993 53230776
Primary biliary cholangitis 21.15 9.85 19 111278 1246 53236523
Anorectal disorder 21.11 9.85 21 111276 1566 53236203
Brain abscess 21.00 9.85 23 111274 1918 53235851
Medication error 20.98 9.85 27 111270 36338 53201431
Spinal cord infection 20.93 9.85 14 111283 592 53237177
Dysplasia 20.93 9.85 15 111282 710 53237059
Fistula of small intestine 20.79 9.85 11 111286 300 53237469
Lupus myocarditis 20.74 9.85 7 111290 58 53237711
Cholesteatoma 20.72 9.85 9 111288 156 53237613
Rectal stenosis 20.72 9.85 9 111288 156 53237613
Peripheral swelling 20.65 9.85 304 110993 205804 53031965
Thrombotic microangiopathy 20.55 9.85 54 111243 9283 53228486
Sebaceous carcinoma 20.53 9.85 6 111291 29 53237740
International normalised ratio increased 20.52 9.85 43 111254 47718 53190051
T-cell lymphoma 20.45 9.85 15 111282 736 53237033
Gestational diabetes 20.31 9.85 49 111248 7990 53229779
Skin ulcer 20.27 9.85 137 111160 35982 53201787
Femur fracture 20.26 9.85 32 111265 39553 53198216
Blood calcium decreased 20.17 9.85 8 111289 19786 53217983
Antineutrophil cytoplasmic antibody increased 20.14 9.85 7 111290 64 53237705
Ileostomy closure 20.10 9.85 8 111289 110 53237659
Hepatitis 19.89 9.85 130 111167 33764 53204005
Transaminases increased 19.82 9.85 119 111178 30013 53207756
Epistaxis 19.78 9.85 75 111222 68635 53169134
Cytomegalovirus hepatitis 19.69 9.85 11 111286 335 53237434
Anaplastic large cell lymphoma T- and null-cell types 19.49 9.85 7 111290 71 53237698
Nasopharyngitis 19.48 9.85 283 111014 192012 53045757
Gastrointestinal fistula 19.44 9.85 12 111285 441 53237328
Candida infection 19.39 9.85 104 111193 25169 53212600
Cerebral toxoplasmosis 19.36 9.85 15 111282 800 53236969
Cough 19.29 9.85 399 110898 256494 52981275
Hepatosplenomegaly 19.26 9.85 25 111272 2493 53235276
Muscle spasms 19.21 9.85 184 111113 134611 53103158
Malignant polyp 19.10 9.85 9 111288 190 53237579
Poisoning 19.10 9.85 3 111294 13847 53223922
Pulmonary embolism 19.07 9.85 150 111147 114292 53123477
Paraesthesia 19.06 9.85 172 111125 127343 53110426
Hyperadrenocorticism 19.03 9.85 11 111286 358 53237411
COVID-19 18.99 9.85 137 111160 36751 53201018
Trichostasis spinulosa 18.97 9.85 5 111292 15 53237754
Abnormal faeces 18.96 9.85 34 111263 4500 53233269
Transient hypogammaglobulinaemia of infancy 18.78 9.85 6 111291 41 53237728
Hypoaesthesia 18.76 9.85 182 111115 132813 53104956
Congenital syphilitic osteochondritis 18.73 9.85 5 111292 16 53237753
Sleep apnoea syndrome 18.72 9.85 16 111281 25986 53211783
Cognitive disorder 18.67 9.85 41 111256 44737 53193032
Device issue 18.65 9.85 11 111286 21647 53216122
Rectal haemorrhage 18.52 9.85 149 111148 41332 53196437
Adverse drug reaction 18.46 9.85 182 111115 53443 53184326
Hip fracture 18.44 9.85 19 111278 28238 53209531
Weber tuning fork test abnormal 18.44 9.85 7 111290 84 53237685
Malignant melanoma 18.44 9.85 57 111240 10745 53227024
Chronic hepatitis 18.44 9.85 15 111282 859 53236910
Underdose 18.43 9.85 11 111286 21511 53216258
Meningitis listeria 18.42 9.85 12 111285 485 53237284
Nightmare 18.38 9.85 7 111290 17744 53220025
Throat cancer 18.25 9.85 12 111285 493 53237276
Body temperature fluctuation 18.22 9.85 22 111275 2039 53235730
Fear 18.19 9.85 6 111291 16635 53221134
Lung abscess 18.17 9.85 20 111277 1677 53236092
Actinic keratosis 18.17 9.85 24 111273 2434 53235335
Transient ischaemic attack 18.17 9.85 29 111268 35696 53202073
Therapy interrupted 18.01 9.85 9 111288 19427 53218342
Lethargy 17.98 9.85 55 111242 53705 53184064
Pseudoxanthoma elasticum-like syndrome 17.93 9.85 4 111293 4 53237765
Mitochondrial neurogastrointestinal encephalopathy 17.93 9.85 4 111293 4 53237765
Injection site pain 17.81 9.85 151 111146 113240 53124529
Withdrawal syndrome 17.79 9.85 9 111288 19292 53218477
Abortion missed 17.75 9.85 20 111277 1721 53236048
Proctectomy 17.75 9.85 6 111291 50 53237719
Hypocalcaemia 17.75 9.85 21 111276 29316 53208453
Drug level abnormal 17.73 9.85 7 111290 94 53237675
Pneumocystis jirovecii infection 17.69 9.85 18 111279 1379 53236390
Anorectal stenosis 17.67 9.85 5 111292 21 53237748
Arthritis enteropathic 17.61 9.85 9 111288 228 53237541
Bronchomalacia 17.61 9.85 9 111288 228 53237541
Abnormal behaviour 17.60 9.85 12 111285 21854 53215915
Anal ulcer 17.58 9.85 12 111285 525 53237244
Polymyositis 17.54 9.85 20 111277 1744 53236025
Tenosynovitis 17.48 9.85 53 111244 9886 53227883
Blood glucose decreased 17.47 9.85 10 111287 20006 53217763
Stress at work 17.40 9.85 16 111281 1081 53236688
Dry skin 17.40 9.85 44 111253 45716 53192053
Oral lichen planus 17.32 9.85 12 111285 538 53237231
Gastrointestinal wall thickening 17.29 9.85 16 111281 1090 53236679
Neutropenia 17.29 9.85 231 111066 158954 53078815
Pulmonary oedema 17.24 9.85 56 111241 53667 53184102
Intestinal polyp 17.18 9.85 17 111280 1259 53236510
Retinal injury 17.09 9.85 9 111288 243 53237526
Enterostomy 17.06 9.85 8 111289 167 53237602
Inappropriate antidiuretic hormone secretion 17.04 9.85 5 111292 14946 53222823
Microsporidia infection 16.89 9.85 9 111288 249 53237520
Polyhydramnios 16.87 9.85 22 111275 2203 53235566
Microscopic polyangiitis 16.72 9.85 8 111289 175 53237594
Dementia 16.69 9.85 7 111290 16743 53221026
Cytomegalovirus mucocutaneous ulcer 16.67 9.85 4 111293 7 53237762
Weight decreased 16.65 9.85 623 110674 234325 53003444
Microtia 16.64 9.85 10 111287 350 53237419
Palatal ulcer 16.61 9.85 6 111291 62 53237707
Gingival hypertrophy 16.51 9.85 18 111279 1493 53236276
Anterograde amnesia 16.51 9.85 11 111286 462 53237307
Defaecation urgency 16.47 9.85 26 111271 3102 53234667
Metastases to bone 16.38 9.85 10 111287 19318 53218451
Pain in extremity 16.38 9.85 461 110836 284589 52953180
B-cell unclassifiable lymphoma high grade 16.32 9.85 4 111293 8 53237761
Vision blurred 16.29 9.85 108 111189 85496 53152273
Retinal toxicity 16.22 9.85 16 111281 1181 53236588
Coronary artery disease 16.21 9.85 28 111269 33409 53204360
American trypanosomiasis 16.20 9.85 6 111291 67 53237702
Pruritus 16.18 9.85 478 110819 293354 52944415
Head injury 16.16 9.85 18 111279 25815 53211954
Pulmonary necrosis 16.13 9.85 7 111290 121 53237648
Aggression 16.13 9.85 15 111282 23388 53214381
Deep vein thrombosis 16.09 9.85 104 111193 82809 53154960
Cleft lip and palate 16.07 9.85 10 111287 373 53237396
Squamous cell carcinoma of the tongue 16.07 9.85 10 111287 373 53237396
Gait disturbance 16.00 9.85 234 111063 158608 53079161
Acute myocardial infarction 15.95 9.85 28 111269 33207 53204562
Diabetic ketoacidosis 15.93 9.85 11 111286 19904 53217865
Gastrointestinal motility disorder 15.92 9.85 33 111264 4863 53232906
Irritability 15.86 9.85 25 111272 30928 53206841
Hirsutism 15.83 9.85 15 111282 1053 53236716
Anaplastic large-cell lymphoma 15.82 9.85 7 111290 127 53237642
Metastases to central nervous system 15.78 9.85 3 111294 12054 53225715
Listeria sepsis 15.77 9.85 12 111285 623 53237146
Pleural effusion 15.75 9.85 114 111183 88465 53149304
Nocardiosis 15.62 9.85 20 111277 1967 53235802
Hyperthyroidism 15.60 9.85 4 111293 13069 53224700
Torsade de pointes 15.48 9.85 4 111293 13001 53224768
Anal squamous cell carcinoma 15.47 9.85 10 111287 399 53237370
Acne conglobata 15.43 9.85 4 111293 11 53237758
Oral pain 15.41 9.85 20 111277 26817 53210952
Eye ulcer 15.32 9.85 9 111288 302 53237467
Myelitis 15.31 9.85 16 111281 1265 53236504
Anovulatory cycle 15.29 9.85 7 111290 138 53237631
Polyomavirus-associated nephropathy 15.23 9.85 18 111279 1631 53236138
Opportunistic infection 15.19 9.85 19 111278 1825 53235944
DNA antibody 15.19 9.85 5 111292 38 53237731
Superinfection 15.18 9.85 21 111276 2226 53235543
Symptom masked 15.04 9.85 12 111285 668 53237101
Cutaneous leishmaniasis 15.04 9.85 6 111291 83 53237686
Haematoma 14.94 9.85 30 111267 33814 53203955
Gastrointestinal scarring 14.93 9.85 8 111289 224 53237545
Lymphoma 14.92 9.85 52 111245 10430 53227339
Tuberous sclerosis complex 14.91 9.85 6 111291 85 53237684
Coloboma 14.91 9.85 6 111291 85 53237684
Herpes virus infection 14.90 9.85 33 111264 5090 53232679
Nervousness 14.87 9.85 25 111272 30153 53207616
Patent ductus arteriosus 14.87 9.85 29 111268 4089 53233680
Gastroenteritis norovirus 14.81 9.85 18 111279 1679 53236090
Anal stenosis 14.80 9.85 9 111288 322 53237447
Obstructive airways disorder 14.80 9.85 9 111288 17420 53220349
Fistula discharge 14.79 9.85 14 111283 982 53236787
Steatorrhoea 14.78 9.85 10 111287 431 53237338
Urinary incontinence 14.76 9.85 26 111271 30795 53206974
Granuloma skin 14.76 9.85 33 111264 5121 53232648
Legionella infection 14.72 9.85 10 111287 434 53237335
Fluid overload 14.72 9.85 22 111275 27809 53209960
Dysphonia 14.68 9.85 42 111255 41896 53195873
Intestinal operation 14.68 9.85 10 111287 436 53237333
Speech disorder 14.64 9.85 38 111259 39143 53198626
Epstein-Barr virus associated lymphoma 14.64 9.85 10 111287 438 53237331
Memory impairment 14.63 9.85 110 111187 84647 53153122
Product administration error 14.60 9.85 14 111283 21517 53216252
Myopathy 14.60 9.85 49 111248 9643 53228126
Pelvic abscess 14.57 9.85 17 111280 1519 53236250
Intestinal anastomosis complication 14.52 9.85 8 111289 237 53237532
Bowel movement irregularity 14.52 9.85 29 111268 4162 53233607
Takayasu's arteritis 14.50 9.85 4 111293 15 53237754
Lung infiltration 14.48 9.85 65 111232 14642 53223127
Congenital bowing of long bones 14.48 9.85 6 111291 92 53237677
Melaena 14.48 9.85 24 111273 29105 53208664
Food intolerance 14.42 9.85 22 111275 2548 53235221
Tonsillar hypertrophy 14.41 9.85 13 111284 857 53236912
Blood parathyroid hormone decreased 14.37 9.85 37 111260 6281 53231488
Mucous stools 14.37 9.85 24 111273 3002 53234767
Foetal exposure during delivery 14.36 9.85 5 111292 46 53237723
Tonsillitis 14.33 9.85 33 111264 5223 53232546
Ureteral neoplasm 14.29 9.85 4 111293 16 53237753
Lymphocytopenia neonatal 14.29 9.85 4 111293 16 53237753
Threatened labour 14.25 9.85 13 111284 870 53236899
Mucormycosis 14.23 9.85 22 111275 2578 53235191
Pulmonary congestion 14.20 9.85 8 111289 16148 53221621
Infective pulmonary exacerbation of cystic fibrosis 14.13 9.85 3 111294 11153 53226616
Failed induction of labour 14.13 9.85 9 111288 350 53237419
Complications of transplanted kidney 14.10 9.85 21 111276 2382 53235387
Pollakiuria 14.08 9.85 20 111277 25819 53211950
Blood potassium increased 14.08 9.85 10 111287 17831 53219938
Endocarditis noninfective 14.08 9.85 5 111292 49 53237720
Muscle spasticity 14.08 9.85 10 111287 17828 53219941
Upper respiratory tract irritation 13.99 9.85 5 111292 50 53237719
Eye infection fungal 13.97 9.85 6 111291 101 53237668
Pericarditis 13.96 9.85 78 111219 64328 53173441
Injection site warmth 13.93 9.85 6 111291 14122 53223647
Sepsis neonatal 13.88 9.85 10 111287 477 53237292
Complex regional pain syndrome 13.87 9.85 20 111277 2203 53235566
Neutrophilic dermatosis 13.81 9.85 6 111291 104 53237665
Anastomotic stenosis 13.76 9.85 8 111289 263 53237506
Acute febrile neutrophilic dermatosis 13.76 9.85 23 111274 2878 53234891
Hepatitis E 13.71 9.85 15 111282 1249 53236520
Post procedural diarrhoea 13.71 9.85 7 111290 177 53237592
Cytomegalovirus chorioretinitis 13.60 9.85 17 111280 1632 53236137
Migraine 13.58 9.85 105 111192 80312 53157457
Anaemia 13.57 9.85 457 110840 276261 52961508
Muscle rigidity 13.56 9.85 3 111294 10838 53226931
Hepatitis viral 13.49 9.85 10 111287 499 53237270
Abnormal palmar/plantar creases 13.48 9.85 5 111292 56 53237713
Fibroadenoma of breast 13.47 9.85 9 111288 380 53237389
Upper gastrointestinal haemorrhage 13.46 9.85 10 111287 17420 53220349
Transplant dysfunction 13.46 9.85 31 111266 4907 53232862
Congenital toxoplasmosis 13.45 9.85 3 111294 3 53237766
Mucosal inflammation 13.45 9.85 45 111252 42739 53195030
Hyperglycaemia 13.41 9.85 41 111256 40043 53197726
Pyometra 13.41 9.85 6 111291 112 53237657
Acute respiratory distress syndrome 13.39 9.85 89 111208 23243 53214526
Kidney fibrosis 13.39 9.85 17 111280 1658 53236111
Pseudomonas infection 13.37 9.85 50 111247 10378 53227391
Epidermodysplasia verruciformis 13.33 9.85 5 111292 58 53237711
Laryngeal stenosis 13.27 9.85 12 111285 794 53236975
Creatinine renal clearance decreased 13.22 9.85 3 111294 10648 53227121
Sinus bradycardia 13.17 9.85 7 111290 14594 53223175
Atypical mycobacterial infection 13.13 9.85 13 111284 964 53236805
Rheumatoid lung 13.11 9.85 20 111277 2317 53235452
Ocular toxicity 13.09 9.85 10 111287 522 53237247
Conjunctivitis allergic 13.08 9.85 12 111285 809 53236960
Device breakage 13.06 9.85 3 111294 10564 53227205
Staphylococcal sepsis 13.04 9.85 41 111256 7799 53229970
Salmonella bacteraemia 13.03 9.85 6 111291 120 53237649
Lung disorder 13.01 9.85 155 111142 47724 53190045
Exercise tolerance increased 12.96 9.85 4 111293 24 53237745
Colostomy 12.96 9.85 11 111286 668 53237101
Disease risk factor 12.95 9.85 5 111292 63 53237706
Depressed mood 12.95 9.85 37 111260 36927 53200842
Staphylococcal skin infection 12.94 9.85 12 111285 820 53236949
Therapy non-responder 12.90 9.85 158 111139 48962 53188807
Rheumatic disorder 12.89 9.85 16 111281 1525 53236244
Anaemia macrocytic 12.87 9.85 22 111275 2804 53234965
Bulimia nervosa 12.85 9.85 10 111287 537 53237232
Obliterative bronchiolitis 12.84 9.85 18 111279 1932 53235837
Anastomotic complication 12.81 9.85 6 111291 125 53237644
Necrotising retinitis 12.77 9.85 8 111289 302 53237467
Myasthenia gravis crisis 12.73 9.85 9 111288 417 53237352
Ventricular tachycardia 12.70 9.85 11 111286 17751 53220018
Placental necrosis 12.69 9.85 4 111293 26 53237743
Fasting 12.69 9.85 4 111293 26 53237743
Anger 12.64 9.85 5 111292 12385 53225384
Sinusitis 12.58 9.85 262 111035 168302 53069467
Carcinoid tumour pulmonary 12.58 9.85 9 111288 425 53237344
Lacrimal haemorrhage 12.56 9.85 4 111293 27 53237742
Photophobia 12.53 9.85 67 111230 16191 53221578
Drug specific antibody 12.52 9.85 16 111281 1571 53236198
Enterococcal sepsis 12.52 9.85 15 111282 1379 53236390
Hypophagia 12.49 9.85 29 111268 31033 53206736
Occult blood 12.47 9.85 14 111283 1200 53236569
Lymphocele 12.45 9.85 12 111285 861 53236908
Stress 12.44 9.85 69 111228 57015 53180754
Muir-Torre syndrome 12.44 9.85 4 111293 28 53237741
Enteritis 12.44 9.85 39 111258 7407 53230362
Encephalitis cytomegalovirus 12.42 9.85 10 111287 564 53237205
Throat irritation 12.40 9.85 30 111267 31651 53206118
Tenderness 12.39 9.85 77 111220 19653 53218116
Type 2 diabetes mellitus 12.39 9.85 30 111267 31640 53206129
Meningitis aseptic 12.34 9.85 28 111269 4387 53233382
Varicella zoster pneumonia 12.32 9.85 4 111293 29 53237740
Product storage error 12.28 9.85 6 111291 13124 53224645
Necrosis 12.28 9.85 31 111266 5200 53232569
Maternal exposure during breast feeding 12.27 9.85 24 111273 3393 53234376
Therapy cessation 12.23 9.85 25 111272 28000 53209769
Ejection fraction decreased 12.23 9.85 14 111283 19834 53217935
Injection site pruritus 12.23 9.85 45 111252 41544 53196225
Seronegative arthritis 12.17 9.85 18 111279 2029 53235740
Sleep disorder due to general medical condition, insomnia type 12.16 9.85 20 111277 24329 53213440
JC virus infection 12.16 9.85 17 111280 1820 53235949
DNA antibody positive 12.09 9.85 8 111289 332 53237437
Infective tenosynovitis 12.02 9.85 7 111290 231 53237538
Hot flush 12.00 9.85 54 111243 47106 53190663
Delusion 12.00 9.85 5 111292 12004 53225765
Bacillary angiomatosis 11.99 9.85 5 111292 78 53237691
Electrolyte imbalance 11.99 9.85 13 111284 18871 53218898
Gastrointestinal stoma complication 11.98 9.85 16 111281 1640 53236129
Cranial sutures widening 11.98 9.85 4 111293 32 53237737
Skin cancer 11.98 9.85 46 111251 9668 53228101
Neoplasm skin 11.96 9.85 13 111284 1075 53236694
Amniotic cavity infection 11.96 9.85 14 111283 1256 53236513
Tuberculosis of eye 11.93 9.85 3 111294 7 53237762
Cheilitis granulomatosa 11.93 9.85 3 111294 7 53237762
Complications of transplanted lung 11.91 9.85 7 111290 235 53237534
Central nervous system necrosis 11.89 9.85 6 111291 148 53237621
Glomerulonephritis 11.87 9.85 16 111281 1655 53236114
Dysarthria 11.86 9.85 44 111253 40524 53197245
Heart rate irregular 11.85 9.85 78 111219 20306 53217463
Large intestinal ulcer 11.83 9.85 23 111274 3236 53234533
Systemic lupus erythematosus 11.81 9.85 344 110953 125070 53112699
Immune-mediated myositis 11.78 9.85 13 111284 1093 53236676
Abdominal pain lower 11.78 9.85 87 111210 23506 53214263
Rash maculo-papular 11.78 9.85 28 111269 29721 53208048
Butterfly rash 11.77 9.85 13 111284 1094 53236675
Gastritis haemorrhagic 11.77 9.85 15 111282 1469 53236300
Thrombocytopenia 11.77 9.85 211 111086 138516 53099253
Ileal ulcer 11.73 9.85 9 111288 473 53237296
Lacrimation increased 11.73 9.85 12 111285 17891 53219878
Ear pain 11.69 9.85 28 111269 29645 53208124
Strabismus congenital 11.66 9.85 4 111293 35 53237734
Muscular dystrophy 11.66 9.85 4 111293 35 53237734
Injection site mass 11.64 9.85 10 111287 16204 53221565
Adjustment disorder with depressed mood 11.64 9.85 20 111277 2560 53235209
Pyoderma 11.62 9.85 7 111290 246 53237523
Hallucination, auditory 11.60 9.85 5 111292 11768 53226001
Breast cancer metastatic 11.57 9.85 9 111288 15319 53222450
Nodule 11.57 9.85 69 111228 17360 53220409
Hypergammaglobulinaemia 11.55 9.85 9 111288 484 53237285
Respiratory gas exchange disorder 11.55 9.85 9 111288 484 53237285
Moraxella infection 11.54 9.85 8 111289 359 53237410
Impetigo 11.53 9.85 13 111284 1120 53236649
Renal cell carcinoma 11.49 9.85 24 111273 3555 53234214
Knee arthroplasty 11.47 9.85 34 111263 33535 53204234
Mucosal necrosis 11.47 9.85 4 111293 37 53237732
Renal colic 11.46 9.85 14 111283 1313 53236456
Rheumatic fever 11.43 9.85 6 111291 12598 53225171
Cervical incompetence 11.43 9.85 10 111287 633 53237136
Cervix carcinoma 11.42 9.85 21 111276 2834 53234935
Sciatica 11.41 9.85 81 111216 21612 53216157
Angina pectoris 11.41 9.85 27 111270 28698 53209071
Cafe au lait spots 11.37 9.85 4 111293 38 53237731
Hidradenitis 11.36 9.85 19 111278 2379 53235390
Mental disorder 11.28 9.85 21 111276 24355 53213414
Blood immunoglobulin M increased 11.25 9.85 7 111290 261 53237508
Ill-defined disorder 11.20 9.85 59 111238 49385 53188384
Proctocolectomy 11.19 9.85 4 111293 40 53237729
Faecal calprotectin abnormal 11.19 9.85 4 111293 40 53237729
Anuria 11.17 9.85 6 111291 12434 53225335
Cholecystitis chronic 11.14 9.85 4 111293 10514 53227255
Precursor T-lymphoblastic lymphoma/leukaemia 11.10 9.85 4 111293 41 53237728
Vertigo 11.05 9.85 70 111227 56011 53181758
Hypocomplementaemia 11.03 9.85 6 111291 173 53237596
Dyspepsia 11.02 9.85 106 111191 77494 53160275
Neuroendocrine carcinoma metastatic 11.00 9.85 6 111291 174 53237595
Skin laceration 11.00 9.85 15 111282 19696 53218073
Haemophilus infection 10.99 9.85 12 111285 997 53236772
Myoclonus 10.98 9.85 10 111287 15754 53222015
Hypoglycaemic seizure 10.98 9.85 9 111288 521 53237248
Anaphylactic shock 10.92 9.85 18 111279 21875 53215894
Renal phospholipidosis 10.90 9.85 5 111292 99 53237670
Appendicectomy 10.87 9.85 20 111277 2701 53235068
Feeling jittery 10.86 9.85 52 111245 12031 53225738
Renal transplant 10.86 9.85 14 111283 1386 53236383
Amnesia 10.85 9.85 53 111244 45235 53192534
Behcet's syndrome 10.81 9.85 5 111292 101 53237668
Infertility 10.81 9.85 10 111287 681 53237088
Swollen joint count increased 10.81 9.85 5 111292 11285 53226484
Dermatitis psoriasiform 10.73 9.85 16 111281 1816 53235953
Primary effusion lymphoma 10.72 9.85 3 111294 12 53237757
Pulmonary venous thrombosis 10.72 9.85 3 111294 12 53237757
Immunoglobulins decreased 10.70 9.85 12 111285 1027 53236742
Pancreatitis acute 10.70 9.85 92 111205 26017 53211752
Small intestinal perforation 10.67 9.85 14 111283 1411 53236358
Eye swelling 10.67 9.85 18 111279 21676 53216093
Anal skin tags 10.66 9.85 7 111290 287 53237482
Lentigo maligna 10.64 9.85 6 111291 186 53237583
Intra-abdominal fluid collection 10.64 9.85 18 111279 2275 53235494
Steroid dependence 10.61 9.85 7 111290 289 53237480
Intestinal dilatation 10.61 9.85 15 111282 1623 53236146
Sepsis 10.53 9.85 389 110908 146040 53091729
Hodgkin's disease stage II 10.53 9.85 3 111294 13 53237756
Intestinal fistula infection 10.53 9.85 3 111294 13 53237756
Poor venous access 10.52 9.85 45 111252 9930 53227839
Pharyngeal oedema 10.51 9.85 9 111288 14604 53223165
Histiocytic necrotising lymphadenitis 10.46 9.85 4 111293 49 53237720
Vasculitis necrotising 10.42 9.85 9 111288 560 53237209
Metastases to liver 10.42 9.85 18 111279 21478 53216291
Stoma site extravasation 10.39 9.85 8 111289 423 53237346
Mycetoma mycotic 10.35 9.85 3 111294 14 53237755
Ubiquinone decreased 10.35 9.85 3 111294 14 53237755
Mouth ulceration 10.32 9.85 100 111197 29226 53208543
Panic attack 10.32 9.85 18 111279 21400 53216369
Intestine transplant rejection 10.32 9.85 4 111293 51 53237718
Bone tuberculosis 10.30 9.85 6 111291 198 53237571
Evans syndrome 10.22 9.85 6 111291 201 53237568
Bronchostenosis 10.19 9.85 8 111289 435 53237334
Ischaemic nephropathy 10.18 9.85 3 111294 15 53237754
Cholestasis 10.17 9.85 98 111199 28597 53209172
Spinal cord disorder 10.17 9.85 13 111284 1277 53236492
Urticarial vasculitis 10.08 9.85 9 111288 585 53237184
Febrile infection 10.08 9.85 13 111284 1288 53236481
Diabetes mellitus inadequate control 10.06 9.85 9 111288 14301 53223468
Infective aortitis 10.02 9.85 3 111294 16 53237753
Chest discomfort 9.99 9.85 147 111150 99548 53138221
Bedridden 9.98 9.85 4 111293 9833 53227936
Autoimmune haemolytic anaemia 9.98 9.85 26 111271 4445 53233324
Steroid diabetes 9.95 9.85 11 111286 927 53236842
Transplant failure 9.95 9.85 14 111283 1508 53236261
Herpes zoster 9.94 9.85 213 111084 73806 53163963
Nail disorder 9.93 9.85 4 111293 9801 53227968
Pneumothorax spontaneous 9.90 9.85 9 111288 599 53237170
Gingival graft 9.87 9.85 3 111294 17 53237752
Portal venous gas 9.86 9.85 4 111293 58 53237711
Breast adenoma 9.86 9.85 4 111293 58 53237711

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Colitis ulcerative 722.77 10.53 437 63032 16614 32433443
Drug ineffective 355.14 10.53 1581 61888 381896 32068161
Off label use 320.18 10.53 1311 62158 305009 32145048
Drug eruption 266.44 10.53 252 63217 18914 32431143
Death 263.77 10.53 217 63252 382300 32067757
Hepatosplenic T-cell lymphoma 258.44 10.53 76 63393 408 32449649
Crohn's disease 252.75 10.53 137 63332 4208 32445849
Post transplant lymphoproliferative disorder 225.30 10.53 141 63328 5693 32444364
Intestinal stenosis 218.83 10.53 97 63372 1898 32448159
Cytomegalovirus infection 200.62 10.53 248 63221 25216 32424841
Nodular regenerative hyperplasia 196.49 10.53 69 63400 702 32449355
Epstein-Barr virus infection 195.62 10.53 139 63330 6951 32443106
Fistula 195.58 10.53 126 63343 5353 32444704
Product use issue 173.03 10.53 343 63126 52434 32397623
Frequent bowel movements 172.51 10.53 145 63324 9307 32440750
Lymphoproliferative disorder 165.50 10.53 87 63382 2508 32447549
Anal abscess 164.48 10.53 114 63355 5476 32444581
Hypersensitivity 164.23 10.53 354 63115 57404 32392653
Hepatic function abnormal 146.44 10.53 291 63178 44549 32405508
Ileal stenosis 143.81 10.53 63 63406 1197 32448860
Drug abuse 141.96 10.53 3 63466 80240 32369817
Diffuse large B-cell lymphoma 138.55 10.53 122 63347 8340 32441717
Intentional product use issue 136.71 10.53 273 63196 41938 32408119
Completed suicide 136.29 10.53 12 63457 92505 32357552
Product use in unapproved indication 129.12 10.53 419 63050 86785 32363272
Fall 129.01 10.53 116 63353 196085 32253972
Therapeutic product effect decreased 125.89 10.53 221 63248 30796 32419261
Disseminated tuberculosis 123.75 10.53 68 63401 2146 32447911
Anal fistula 122.88 10.53 87 63382 4324 32445733
Squamous cell carcinoma 120.60 10.53 127 63342 10841 32439216
Intestinal obstruction 119.96 10.53 174 63295 20624 32429433
Disease recurrence 119.39 10.53 152 63317 15912 32434145
Cytomegalovirus colitis 115.15 10.53 69 63400 2573 32447484
Haemophagocytic lymphohistiocytosis 113.65 10.53 125 63344 11210 32438847
Transplant rejection 112.12 10.53 117 63352 9882 32440175
Febrile neutropenia 111.35 10.53 47 63422 119519 32330538
Pemphigus 111.28 10.53 54 63415 1308 32448749
Hypotension 111.23 10.53 156 63313 215954 32234103
Infusion related reaction 109.01 10.53 261 63208 45338 32404719
Stomatitis 104.62 10.53 238 63231 39991 32410066
Large intestinal stenosis 103.80 10.53 52 63417 1352 32448705
Blood pressure fluctuation 101.23 10.53 158 63311 19977 32430080
JC virus infection 100.57 10.53 57 63412 1912 32448145
Pulmonary tuberculosis 98.25 10.53 80 63389 4909 32445148
Urticaria 97.90 10.53 297 63172 59317 32390740
Treatment failure 97.77 10.53 228 63241 38935 32411122
Premature baby 96.86 10.53 148 63321 18370 32431687
Leukopenia 96.37 10.53 297 63172 59825 32390232
Acute febrile neutrophilic dermatosis 93.05 10.53 47 63422 1244 32448813
Pancytopenia 92.57 10.53 388 63081 90847 32359210
Malignant neoplasm progression 90.63 10.53 21 63448 78475 32371582
Progressive multifocal leukoencephalopathy 90.22 10.53 102 63367 9429 32440628
Intestinal fistula 90.18 10.53 41 63428 853 32449204
Epstein-Barr virus associated lymphoproliferative disorder 89.54 10.53 52 63417 1828 32448229
Myocardial infarction 89.05 10.53 69 63400 125607 32324450
Pneumocystis jirovecii pneumonia 87.89 10.53 143 63326 18727 32431330
Toxicity to various agents 87.16 10.53 133 63336 177908 32272149
Somnolence 87.14 10.53 47 63422 103750 32346307
Dizziness 86.84 10.53 174 63295 209444 32240613
Basal cell carcinoma 84.37 10.53 135 63334 17433 32432624
Intestinal resection 83.58 10.53 46 63423 1456 32448601
Faecal calprotectin increased 83.45 10.53 45 63424 1367 32448690
Cushingoid 82.12 10.53 56 63413 2618 32447439
Epistaxis 80.46 10.53 266 63203 55589 32394468
Kidney transplant rejection 80.31 10.53 87 63382 7668 32442389
Drug level below therapeutic 79.95 10.53 66 63403 4129 32445928
Condition aggravated 78.31 10.53 546 62923 155115 32294942
Human herpesvirus 8 infection 76.73 10.53 36 63433 807 32449250
Small intestinal stenosis 76.17 10.53 30 63439 430 32449627
Colitis 75.45 10.53 189 63280 33762 32416295
Tuberculosis 73.56 10.53 88 63381 8641 32441416
Acute kidney injury 73.05 10.53 310 63159 293158 32156899
Erythema nodosum 72.61 10.53 37 63432 998 32449059
Drug specific antibody present 71.73 10.53 50 63419 2423 32447634
Cardiac failure congestive 70.36 10.53 39 63430 84813 32365244
Confusional state 69.92 10.53 107 63362 143008 32307049
Dyspnoea 69.88 10.53 418 63051 361627 32088430
Drug level decreased 69.72 10.53 74 63395 6372 32443685
Abdominal pain 68.56 10.53 513 62956 149016 32301041
Squamous cell carcinoma of skin 68.35 10.53 90 63379 9736 32440321
Diarrhoea haemorrhagic 68.19 10.53 72 63397 6163 32443894
Coombs positive haemolytic anaemia 67.90 10.53 33 63436 802 32449255
Inappropriate schedule of product administration 67.57 10.53 220 63249 45605 32404452
Muscle spasms 64.14 10.53 290 63179 70128 32379929
Herpes zoster 62.61 10.53 171 63298 32170 32417887
Lymphopenia 62.55 10.53 106 63363 14350 32435707
T-cell lymphoma 61.60 10.53 33 63436 989 32449068
Plasma cell myeloma 61.56 10.53 18 63451 57596 32392461
Nocardiosis 61.49 10.53 54 63415 3677 32446380
Immunosuppression 61.48 10.53 65 63404 5572 32444485
Abscess 61.25 10.53 89 63380 10561 32439496
Non-cirrhotic portal hypertension 61.03 10.53 22 63447 243 32449814
Bradycardia 60.63 10.53 32 63437 71530 32378527
Colectomy 60.54 10.53 38 63431 1541 32448516
Gastrointestinal inflammation 60.48 10.53 50 63419 3134 32446923
Atrial fibrillation 60.17 10.53 84 63385 116620 32333437
Drug intolerance 60.05 10.53 225 63244 50010 32400047
Lung transplant rejection 59.74 10.53 30 63439 784 32449273
Hand deformity 59.71 10.53 42 63427 2065 32447992
Product dose omission issue 58.93 10.53 68 63401 102507 32347550
Histoplasmosis disseminated 58.49 10.53 33 63436 1097 32448960
Clear cell renal cell carcinoma 58.11 10.53 32 63437 1014 32449043
Lymphadenitis 58.10 10.53 39 63430 1776 32448281
Hyponatraemia 57.90 10.53 37 63432 74476 32375581
Abdominal adhesions 57.86 10.53 35 63434 1328 32448729
Meningitis listeria 57.70 10.53 24 63445 399 32449658
B-cell lymphoma 57.14 10.53 57 63412 4562 32445495
Cytomegalovirus viraemia 56.98 10.53 68 63401 6659 32443398
Foetal exposure during pregnancy 55.32 10.53 192 63277 41109 32408948
Epstein-Barr virus test positive 55.12 10.53 25 63444 517 32449540
Dehydration 55.09 10.53 105 63364 128853 32321204
Cardiac arrest 54.69 10.53 65 63404 96711 32353346
Night sweats 54.40 10.53 106 63363 15982 32434075
Epstein-Barr virus associated lymphoma 53.98 10.53 26 63443 619 32449438
Immunoglobulin G4 related disease 53.48 10.53 16 63453 92 32449965
Cytomegalovirus enteritis 52.45 10.53 23 63446 438 32449619
Intestinal perforation 52.25 10.53 75 63394 8800 32441257
Lymphoma 51.86 10.53 83 63386 10717 32439340
Transplant dysfunction 51.78 10.53 41 63428 2416 32447641
Haematochezia 51.41 10.53 181 63288 39027 32411030
Overdose 50.80 10.53 57 63412 87020 32363037
Therapeutic response shortened 50.72 10.53 54 63415 4666 32445391
Kaposi's sarcoma 50.62 10.53 29 63440 993 32449064
Defaecation urgency 50.32 10.53 35 63434 1690 32448367
Small intestinal obstruction 49.79 10.53 95 63374 14101 32435956
Decreased appetite 49.03 10.53 156 63313 160657 32289400
Chronic allograft nephropathy 49.01 10.53 30 63439 1163 32448894
Cardio-respiratory arrest 48.97 10.53 24 63445 55965 32394092
Heart transplant rejection 48.89 10.53 31 63438 1280 32448777
Renal cell carcinoma 48.36 10.53 59 63410 5911 32444146
Intentional overdose 48.26 10.53 11 63458 41590 32408467
Pain in extremity 47.87 10.53 396 63073 118505 32331552
Pneumonia aspiration 47.51 10.53 11 63458 41145 32408912
Syncope 47.31 10.53 64 63405 90060 32359997
Polyhydramnios 46.88 10.53 18 63451 240 32449817
Neuropathy peripheral 46.44 10.53 49 63420 76933 32373124
Portal hypertension 46.35 10.53 48 63421 4016 32446041
Type 2 lepra reaction 46.04 10.53 20 63449 372 32449685
Granulomatosis with polyangiitis 45.76 10.53 27 63442 978 32449079
Myasthenia gravis 45.37 10.53 45 63424 3577 32446480
Rebound effect 44.82 10.53 35 63434 2021 32448036
Loss of consciousness 44.16 10.53 58 63411 82649 32367408
Peliosis hepatis 44.07 10.53 12 63457 46 32450011
Blood glucose increased 43.46 10.53 38 63431 65203 32384854
Histoplasmosis 43.43 10.53 29 63440 1309 32448748
Acute myocardial infarction 43.36 10.53 27 63442 55122 32394935
Lymphocytopenia neonatal 42.58 10.53 9 63460 6 32450051
Insomnia 42.58 10.53 82 63387 100266 32349791
Aspergillus infection 42.51 10.53 79 63390 11495 32438562
Chronic obstructive pulmonary disease 42.48 10.53 21 63448 48732 32401325
Systemic lupus erythematosus 41.64 10.53 39 63430 2887 32447170
Rheumatoid factor negative 40.86 10.53 23 63446 761 32449296
Aggression 40.82 10.53 13 63456 39376 32410681
Delirium 39.87 10.53 18 63451 44028 32406029
Hypoglycaemia 39.57 10.53 29 63440 54353 32395704
Rash 39.55 10.53 243 63226 209090 32240967
Clostridium difficile infection 39.45 10.53 99 63370 17697 32432360
Neuroendocrine carcinoma of the skin 39.33 10.53 21 63448 625 32449432
Bronchopulmonary aspergillosis 38.96 10.53 84 63385 13603 32436454
Inflammatory bowel disease 38.63 10.53 35 63434 2483 32447574
Extrapulmonary tuberculosis 38.62 10.53 13 63456 115 32449942
Abscess intestinal 38.44 10.53 28 63441 1455 32448602
Therapeutic product effect incomplete 38.17 10.53 171 63298 41170 32408887
Anal fissure 38.03 10.53 37 63432 2872 32447185
Candida infection 37.80 10.53 94 63375 16709 32433348
Abnormal behaviour 37.45 10.53 4 63465 26462 32423595
Infection reactivation 37.37 10.53 25 63444 1132 32448925
Mycobacterial infection 37.19 10.53 31 63438 1965 32448092
Cardiac failure 37.10 10.53 77 63392 91596 32358461
Cholangitis sclerosing 37.02 10.53 24 63445 1030 32449027
Pancreatitis 36.89 10.53 160 63309 37991 32412066
Cutaneous T-cell lymphoma 36.38 10.53 27 63442 1444 32448613
Rectal fissure 36.09 10.53 16 63453 313 32449744
Mycoplasma infection 36.04 10.53 16 63453 314 32449743
International normalised ratio increased 35.87 10.53 26 63443 49009 32401048
Arthralgia 35.85 10.53 445 63024 148003 32302054
Hallucination 35.84 10.53 30 63439 52589 32397468
Wrong technique in product usage process 35.57 10.53 12 63457 35047 32415010
Lymphocyte count abnormal 35.36 10.53 20 63449 668 32449389
Cerebrovascular accident 35.36 10.53 72 63397 86248 32363809
Varicella zoster virus infection 34.96 10.53 27 63442 1534 32448523
Respiratory arrest 34.84 10.53 7 63462 28901 32421156
Lupus-like syndrome 34.79 10.53 32 63437 2315 32447742
Red blood cell sedimentation rate abnormal 34.22 10.53 31 63438 2199 32447858
Enterocutaneous fistula 34.10 10.53 21 63448 823 32449234
Vasculitis 34.03 10.53 61 63408 8632 32441425
Intestinal fibrosis 33.44 10.53 11 63458 90 32449967
Therapeutic response decreased 33.41 10.53 119 63350 25801 32424256
Coma 33.31 10.53 21 63448 42591 32407466
Electrocardiogram QT prolonged 33.16 10.53 18 63451 39623 32410434
Oedema peripheral 33.14 10.53 113 63356 113978 32336079
Visceral leishmaniasis 33.07 10.53 18 63451 557 32449500
Bone marrow failure 32.91 10.53 132 63337 30272 32419785
Fatigue 32.74 10.53 485 62984 350216 32099841
Gastrointestinal disorder 32.45 10.53 133 63336 30798 32419259
Pyrexia 32.37 10.53 835 62634 319133 32130924
Weight decreased 32.37 10.53 476 62993 164342 32285715
Herpes simplex 32.35 10.53 45 63424 5129 32444928
Anxiety 32.21 10.53 89 63380 95916 32354141
Asthenia 31.74 10.53 301 63168 235643 32214414
Obliterative bronchiolitis 31.49 10.53 23 63446 1200 32448857
Abdominal abscess 31.44 10.53 40 63429 4181 32445876
Orthostatic hypotension 31.36 10.53 6 63463 25644 32424413
Steroid dependence 31.25 10.53 12 63457 160 32449897
Low birth weight baby 31.20 10.53 52 63417 6942 32443115
Hypokalaemia 31.11 10.53 37 63432 55057 32395000
Gastrointestinal wall thickening 31.07 10.53 22 63447 1093 32448964
Henoch-Schonlein purpura 31.05 10.53 26 63443 1659 32448398
Complications of transplanted kidney 30.93 10.53 40 63429 4250 32445807
Rectal abscess 30.62 10.53 21 63448 991 32449066
Myopathy 30.46 10.53 68 63401 11273 32438784
Gastrointestinal fistula 30.37 10.53 15 63454 378 32449679
Urinary retention 30.16 10.53 16 63453 35681 32414376
Foetal growth restriction 29.86 10.53 38 63431 3974 32446083
Gastrointestinal lymphoma 29.73 10.53 8 63461 29 32450028
Fistula discharge 29.73 10.53 15 63454 396 32449661
Agitation 29.67 10.53 41 63428 57195 32392862
Gastrointestinal haemorrhage 29.55 10.53 80 63389 86802 32363255
Cow pox 29.52 10.53 8 63461 30 32450027
Cystitis escherichia 29.44 10.53 12 63457 189 32449868
Limb deformity 29.34 10.53 16 63453 497 32449560
Dysgeusia 29.11 10.53 7 63462 25524 32424533
Gait disturbance 28.91 10.53 72 63397 80336 32369721
Rectal haemorrhage 28.89 10.53 147 63322 37276 32412781
Acquired gene mutation 28.87 10.53 22 63447 1225 32448832
Heart rate irregular 28.81 10.53 76 63393 14002 32436055
Squamous cell carcinoma of the tongue 28.66 10.53 12 63457 203 32449854
Papilloma viral infection 28.64 10.53 15 63454 429 32449628
Mycobacterium chelonae infection 28.56 10.53 17 63452 626 32449431
Enteritis 28.49 10.53 51 63418 7210 32442847
Lung neoplasm 28.47 10.53 40 63429 4601 32445456
Scleroderma 28.44 10.53 23 63446 1397 32448660
Chronic gastrointestinal bleeding 28.44 10.53 13 63456 274 32449783
Neutrophil count decreased 28.43 10.53 30 63439 47109 32402948
Herpes zoster meningoencephalitis 28.39 10.53 13 63456 275 32449782
Cytomegalovirus infection reactivation 28.36 10.53 34 63435 3345 32446712
Therapeutic reaction time decreased 28.24 10.53 17 63452 639 32449418
Angina pectoris 28.19 10.53 13 63456 31413 32418644
Depressed level of consciousness 28.17 10.53 23 63446 40824 32409233
Nephropathy toxic 28.11 10.53 68 63401 11878 32438179
Hospitalisation 27.53 10.53 33 63436 48938 32401119
Pouchitis 27.52 10.53 17 63452 670 32449387
Balance disorder 27.48 10.53 22 63447 39437 32410620
Actinic keratosis 27.48 10.53 36 63433 3874 32446183
Splenomegaly 27.46 10.53 76 63393 14401 32435656
Seizure 27.43 10.53 107 63362 103747 32346310
Disease progression 27.33 10.53 83 63386 86779 32363278
Listeria sepsis 27.29 10.53 11 63458 168 32449889
Accidental overdose 27.16 10.53 3 63466 19336 32430721
Intestinal anastomosis 27.10 10.53 12 63457 234 32449823
Unresponsive to stimuli 27.07 10.53 10 63459 27599 32422458
Disorientation 26.78 10.53 16 63453 33409 32416648
Legionella infection 26.77 10.53 15 63454 492 32449565
Liver transplant rejection 26.74 10.53 27 63442 2192 32447865
Myasthenic syndrome 26.58 10.53 14 63455 405 32449652
Complications of transplanted lung 26.28 10.53 11 63458 186 32449871
Hepatosplenomegaly 25.99 10.53 35 63434 3868 32446189
Ileostomy 25.91 10.53 15 63454 524 32449533
Dyskinesia 25.90 10.53 7 63462 23596 32426461
Myasthenia gravis crisis 25.89 10.53 15 63454 525 32449532
Irritability 25.78 10.53 8 63461 24646 32425411
Molluscum contagiosum 25.70 10.53 12 63457 266 32449791
Contusion 25.46 10.53 17 63452 33451 32416606
White blood cell count decreased 25.35 10.53 92 63377 91106 32358951
Tachycardia 25.29 10.53 75 63394 79013 32371044
Periumbilical abscess 25.28 10.53 8 63461 57 32450000
Epstein Barr virus positive mucocutaneous ulcer 25.17 10.53 12 63457 279 32449778
Graft versus host disease in lung 25.13 10.53 15 63454 555 32449502
Meningitis cryptococcal 25.03 10.53 26 63443 2183 32447874
Pyoderma gangrenosum 24.97 10.53 20 63449 1198 32448859
Lupus nephritis 24.90 10.53 12 63457 286 32449771
Malignant melanoma 24.78 10.53 51 63418 7995 32442062
Subcutaneous abscess 24.70 10.53 34 63435 3836 32446221
Diffuse large B-cell lymphoma stage IV 24.64 10.53 12 63457 293 32449764
Osteonecrosis of jaw 24.48 10.53 4 63465 19162 32430895
Transient ischaemic attack 24.20 10.53 10 63459 25784 32424273
Phaeohyphomycosis 24.02 10.53 17 63452 844 32449213
Plasmablastic lymphoma 23.81 10.53 12 63457 316 32449741
Bone erosion 23.71 10.53 28 63441 2711 32447346
Strongyloidiasis 23.54 10.53 27 63442 2534 32447523
Drug resistance 23.50 10.53 98 63371 22867 32427190
Body temperature fluctuation 23.38 10.53 21 63448 1473 32448584
Hypocalcaemia 23.20 10.53 8 63461 23046 32427011
Constipation 23.15 10.53 148 63321 126225 32323832
Hydrops foetalis 22.95 10.53 11 63458 259 32449798
Peritoneal abscess 22.90 10.53 8 63461 80 32449977
Listeria encephalitis 22.87 10.53 7 63462 44 32450013
Intestinal anastomosis complication 22.72 10.53 9 63460 131 32449926
Narcotic bowel syndrome 22.66 10.53 9 63460 132 32449925
Non-Hodgkin's lymphoma 22.61 10.53 22 63447 1708 32448349
Autoimmune hepatitis 22.54 10.53 33 63436 3942 32446115
Growth retardation 22.51 10.53 22 63447 1717 32448340
Intestinal mass 22.49 10.53 13 63456 453 32449604
Herpes simplex hepatitis 22.47 10.53 8 63461 85 32449972
Lung abscess 22.29 10.53 27 63442 2685 32447372
Cutaneous leishmaniasis 22.26 10.53 10 63459 202 32449855
Coronary artery disease 21.61 10.53 40 63429 49666 32400391
Stevens-Johnson syndrome 21.59 10.53 5 63464 18704 32431353
Congenital cytomegalovirus infection 21.45 10.53 6 63463 26 32450031
Eosinophilic granulomatosis with polyangiitis 21.45 10.53 20 63449 1472 32448585
Depression 21.38 10.53 107 63362 96953 32353104
Oesophageal atresia 21.38 10.53 13 63456 498 32449559
Eosinophilic bronchitis 21.35 10.53 9 63460 155 32449902
Immunosuppressant drug level increased 21.30 10.53 37 63432 5108 32444949
Congenital cystic lung 21.20 10.53 10 63459 227 32449830
Congenital oesophageal anomaly 21.16 10.53 8 63461 102 32449955
Hepatitis 21.11 10.53 97 63372 23596 32426461
Combined immunodeficiency 21.10 10.53 7 63462 59 32449998
Hepatic enzyme increased 21.01 10.53 134 63335 36903 32413154
Hyperkalaemia 20.98 10.53 68 63401 69682 32380375
C-reactive protein increased 20.84 10.53 163 63306 47939 32402118
Odynophagia 20.59 10.53 36 63433 4995 32445062
Cytomegalovirus chorioretinitis 20.50 10.53 30 63439 3582 32446475
Central nervous system lesion 20.41 10.53 39 63430 5793 32444264
Optic neuritis 20.39 10.53 29 63440 3373 32446684
Gastrointestinal mucosa hyperaemia 20.39 10.53 10 63459 248 32449809
Haemolysis 20.33 10.53 46 63423 7695 32442362
Varicella 20.29 10.53 20 63449 1577 32448480
Osteoporosis 20.25 10.53 61 63408 12121 32437936
Suicide attempt 20.21 10.53 27 63442 38217 32411840
Autoimmune haemolytic anaemia 20.16 10.53 33 63436 4341 32445716
Iron deficiency 20.14 10.53 28 63441 3189 32446868
Laryngeal mass 19.98 10.53 6 63463 35 32450022
Subdural haematoma 19.94 10.53 7 63462 19946 32430111
Rhabdomyolysis 19.94 10.53 66 63403 67199 32382858
Angioedema 19.82 10.53 25 63444 36264 32413793
Cardiac disorder 19.74 10.53 32 63437 41834 32408223
Pulmonary vasculitis 19.63 10.53 8 63461 126 32449931
Mucocutaneous leishmaniasis 19.61 10.53 7 63462 75 32449982
Ileal ulcer 19.60 10.53 13 63456 580 32449477
Viral infection 19.58 10.53 73 63396 16177 32433880
Lymphocytic infiltration 19.57 10.53 14 63455 707 32449350
Product prescribing error 19.57 10.53 7 63462 19710 32430347
Mucosal inflammation 19.36 10.53 22 63447 33412 32416645
Metabolic acidosis 19.29 10.53 31 63438 40668 32409389
Polyomavirus-associated nephropathy 19.28 10.53 29 63440 3548 32446509
Gastrointestinal stoma complication 19.20 10.53 18 63451 1334 32448723
Chorioretinopathy 19.18 10.53 19 63450 1508 32448549
Tonsil cancer 19.10 10.53 15 63454 873 32449184
Gastrointestinal stenosis 19.05 10.53 7 63462 82 32449975
Granuloma 18.94 10.53 25 63444 2710 32447347
Gallbladder polyp 18.93 10.53 11 63458 387 32449670
Skin lesion 18.88 10.53 84 63385 20157 32429900
Episcleritis 18.86 10.53 8 63461 140 32449917
Protein deficiency 18.73 10.53 4 63465 3 32450054
Asthma 18.68 10.53 36 63433 44029 32406028
Amnesia 18.67 10.53 13 63456 25023 32425034
Hypersensitivity vasculitis 18.65 10.53 29 63440 3652 32446405
Chronic myeloid leukaemia 18.59 10.53 25 63444 2759 32447298
Hodgkin's disease 18.55 10.53 15 63454 911 32449146
Hyperglycaemia 18.43 10.53 29 63440 38362 32411695
Lactic acidosis 18.42 10.53 23 63446 33513 32416544
Jejunal stenosis 18.36 10.53 6 63463 48 32450009
Autoimmune neutropenia 18.30 10.53 10 63459 312 32449745
Drug level above therapeutic 18.27 10.53 27 63442 3251 32446806
Herpes simplex test positive 18.18 10.53 9 63460 228 32449829
Paracoccidioides infection 18.12 10.53 7 63462 95 32449962
Drug specific antibody absent 18.04 10.53 6 63463 51 32450006
Arthritis 17.97 10.53 101 63368 26591 32423466
Aplasia pure red cell 17.96 10.53 37 63432 5805 32444252
Large intestinal ulcer 17.95 10.53 20 63449 1818 32448239
Acute pulmonary histoplasmosis 17.73 10.53 7 63462 101 32449956
Chest pain 17.68 10.53 156 63313 123981 32326076
Cytomegalovirus test positive 17.61 10.53 29 63440 3833 32446224
Brain abscess 17.57 10.53 25 63444 2909 32447148
Anal cancer 17.53 10.53 11 63458 446 32449611
Serum sickness 17.39 10.53 20 63449 1883 32448174
Infectious mononucleosis 17.37 10.53 11 63458 453 32449604
Butterfly rash 17.36 10.53 7 63462 107 32449950
Oesophagopleural fistula 17.36 10.53 6 63463 58 32449999
Pruritus 17.35 10.53 164 63305 128538 32321519
Pneumonia cytomegaloviral 17.32 10.53 25 63444 2947 32447110
Skin cancer 17.32 10.53 47 63422 8803 32441254
Laser therapy 17.31 10.53 4 63465 6 32450051
Intestinal ulcer 17.25 10.53 14 63455 855 32449202
Hemivertebra 17.25 10.53 7 63462 109 32449948
Urinary tract infection 17.22 10.53 89 63380 79982 32370075
Intestinal diaphragm disease 17.16 10.53 9 63460 258 32449799
Disseminated cytomegaloviral infection 16.94 10.53 8 63461 182 32449875
Cytomegalovirus duodenitis 16.91 10.53 6 63463 63 32449994
Cytokine release syndrome 16.90 10.53 3 63466 13532 32436525
Proctitis 16.87 10.53 22 63447 2356 32447701
Retinal scar 16.85 10.53 9 63460 268 32449789
Disturbance in attention 16.85 10.53 13 63456 23740 32426317
Pancreatitis acute 16.82 10.53 101 63368 27234 32422823
Pulmonary granuloma 16.78 10.53 17 63452 1386 32448671
Acne 16.76 10.53 51 63418 10191 32439866
Marrow hyperplasia 16.64 10.53 15 63454 1057 32449000
Erectile dysfunction 16.60 10.53 9 63460 19830 32430227
Cytomegalovirus syndrome 16.58 10.53 7 63462 121 32449936
Relapsing fever 16.55 10.53 8 63461 192 32449865
Splenic embolism 16.51 10.53 8 63461 193 32449864
Testicular cancer metastatic 16.50 10.53 6 63463 68 32449989
Gastrointestinal obstruction 16.40 10.53 13 63456 767 32449290
Drug ineffective for unapproved indication 16.35 10.53 62 63407 13850 32436207
Diabetes mellitus 16.33 10.53 147 63322 45026 32405031
Fluid overload 16.27 10.53 9 63460 19612 32430445
Gastroenteritis clostridial 16.26 10.53 9 63460 288 32449769
Peripheral T-cell lymphoma unspecified stage IV 16.13 10.53 5 63464 33 32450024
Listeriosis 16.12 10.53 14 63455 939 32449118
Blood creatine phosphokinase increased 16.12 10.53 41 63428 45435 32404622
Pseudopolyp 16.11 10.53 8 63461 204 32449853
Anorectal stenosis 15.97 10.53 4 63465 10 32450047
Aspartate aminotransferase increased 15.94 10.53 71 63398 66358 32383699
Rectal discharge 15.93 10.53 7 63462 134 32449923
Small intestine carcinoma 15.93 10.53 11 63458 525 32449532
Platelet count decreased 15.88 10.53 145 63324 114446 32335611
Spermatozoa progressive motility decreased 15.79 10.53 7 63462 137 32449920
Stiff person syndrome 15.79 10.53 7 63462 137 32449920
Aqueductal stenosis 15.72 10.53 3 63466 0 32450057
Uveal melanoma 15.72 10.53 3 63466 0 32450057
Arrhythmia 15.71 10.53 28 63441 35275 32414782
Mental status changes 15.67 10.53 32 63437 38305 32411752
Gastric fistula 15.63 10.53 6 63463 80 32449977
Urinary incontinence 15.62 10.53 8 63461 18199 32431858
Nausea 15.46 10.53 493 62976 320356 32129701
Viral test positive 15.46 10.53 8 63461 223 32449834
Neoplasm skin 15.42 10.53 11 63458 553 32449504
Haematuria 15.35 10.53 46 63423 48315 32401742
Full blood count decreased 15.31 10.53 7 63462 17003 32433054
Rectal cancer 15.21 10.53 21 63448 2376 32447681
Cardiac myxoma 15.20 10.53 4 63465 13 32450044
Haemophilus bacteraemia 15.20 10.53 4 63465 13 32450044
Haemorrhage intracranial 15.16 10.53 6 63463 15881 32434176
Coloboma 15.12 10.53 7 63462 152 32449905
Cryptococcal cutaneous infection 15.11 10.53 6 63463 88 32449969
Gastrointestinal cancer metastatic 14.99 10.53 6 63463 90 32449967
Sideroblastic anaemia 14.98 10.53 8 63461 238 32449819
Herpes simplex colitis 14.97 10.53 4 63465 14 32450043
Chronic graft versus host disease in intestine 14.95 10.53 8 63461 239 32449818
Dry mouth 14.93 10.53 15 63454 24104 32425953
Skin papilloma 14.87 10.53 18 63451 1788 32448269
Hepatitis B 14.82 10.53 36 63433 6305 32443752
Ejection fraction decreased 14.79 10.53 8 63461 17650 32432407
Uveitis 14.78 10.53 36 63433 6314 32443743
Testis cancer 14.78 10.53 12 63457 733 32449324
Meconium peritonitis 14.76 10.53 4 63465 15 32450042
Metastases to lymph nodes 14.75 10.53 29 63440 4399 32445658
Functional gastrointestinal disorder 14.74 10.53 20 63449 2226 32447831
Neonatal respiratory failure 14.70 10.53 9 63460 349 32449708
Microscopic polyangiitis 14.68 10.53 7 63462 163 32449894
Dementia 14.63 10.53 4 63465 13382 32436675
Respiratory tract infection fungal 14.63 10.53 12 63457 744 32449313
Mycobacterium kansasii infection 14.60 10.53 8 63461 251 32449806
Ventricular tachycardia 14.59 10.53 17 63452 25539 32424518
Pulmonary nocardiosis 14.47 10.53 11 63458 610 32449447
Arthropathy 14.42 10.53 84 63385 22405 32427652
Vomiting 14.40 10.53 350 63119 235207 32214850
Cryptococcosis 14.38 10.53 19 63450 2061 32447996
Pneumoperitoneum 14.33 10.53 18 63451 1858 32448199
Tender joint count increased 14.31 10.53 5 63464 50 32450007
Vitamin B1 decreased 14.26 10.53 8 63461 263 32449794
Posterior reversible encephalopathy syndrome 14.12 10.53 46 63423 9530 32440527
Lymph node tuberculosis 14.10 10.53 10 63459 498 32449559
Extrapyramidal disorder 14.08 10.53 3 63466 11892 32438165
Pneumocystis jirovecii infection 14.03 10.53 16 63453 1492 32448565
Sleep disorder 14.02 10.53 19 63450 26733 32423324
Poor venous access 13.95 10.53 23 63446 3043 32447014
Dyspnoea exertional 13.90 10.53 35 63434 38926 32411131
Peritoneal candidiasis 13.84 10.53 4 63465 20 32450037
Disseminated cryptococcosis 13.83 10.53 14 63455 1140 32448917
Therapy non-responder 13.78 10.53 110 63359 32544 32417513
Unevaluable event 13.75 10.53 28 63441 33558 32416499
Gastrointestinal scarring 13.69 10.53 6 63463 114 32449943
Intentional self-injury 13.68 10.53 5 63464 13895 32436162
Hepatobiliary cancer 13.65 10.53 3 63466 3 32450054
Precursor T-lymphoblastic lymphoma/leukaemia stage I 13.65 10.53 3 63466 3 32450054
Hepatic angiosarcoma 13.65 10.53 3 63466 3 32450054
Oropharyngeal squamous cell carcinoma 13.63 10.53 7 63462 192 32449865
Enterovesical fistula 13.62 10.53 11 63458 667 32449390
Rash maculo-papular 13.61 10.53 21 63448 28001 32422056
Appendiceal abscess 13.57 10.53 5 63464 59 32449998
Small intestinal ulcer haemorrhage 13.57 10.53 5 63464 59 32449998
Necrotising herpetic retinopathy 13.52 10.53 4 63465 22 32450035
Pulmonary paracoccidioidomycosis 13.52 10.53 4 63465 22 32450035
Overgrowth bacterial 13.50 10.53 6 63463 118 32449939
Drug tolerance decreased 13.49 10.53 15 63454 1361 32448696
Blood bilirubin decreased 13.48 10.53 8 63461 293 32449764
Aphthous ulcer 13.46 10.53 28 63441 4423 32445634
Neutropenia 13.41 10.53 196 63273 141979 32308078
Campylobacter gastroenteritis 13.39 10.53 12 63457 839 32449218
Drug interaction 13.38 10.53 324 63145 217861 32232196
Pain 13.36 10.53 272 63197 187284 32262773
Proctocolectomy 13.35 10.53 5 63464 62 32449995
Skin hyperpigmentation 13.34 10.53 23 63446 3155 32446902
Peritoneal tuberculosis 13.31 10.53 9 63460 415 32449642
Cytomegalovirus oesophagitis 13.29 10.53 9 63460 416 32449641
Small intestine adenocarcinoma 13.28 10.53 6 63463 123 32449934
Altered state of consciousness 13.26 10.53 14 63455 21983 32428074
Pseudolymphoma 13.23 10.53 10 63459 550 32449507
Olfactory nerve disorder 13.23 10.53 4 63465 24 32450033
Memory impairment 13.21 10.53 38 63431 40441 32409616
Diffuse large B-cell lymphoma stage III 13.21 10.53 5 63464 64 32449993
Gastrointestinal oedema 13.20 10.53 15 63454 1393 32448664
Hyperhidrosis 13.20 10.53 83 63386 71085 32378972
Cholangitis chronic 13.19 10.53 3 63466 4 32450053
Injection site pain 13.16 10.53 28 63441 33030 32417027
Colonic abscess 13.15 10.53 9 63460 423 32449634
Thrombocytopenia 13.12 10.53 207 63262 148092 32301965
Anal stenosis 13.10 10.53 6 63463 127 32449930
Brachycephaly 13.07 10.53 5 63464 66 32449991
Musculoskeletal discomfort 13.06 10.53 36 63433 6804 32443253
Anaplastic large cell lymphoma T- and null-cell types 13.06 10.53 6 63463 128 32449929
Myelitis transverse 13.06 10.53 13 63456 1038 32449019
Anorectal disorder 13.02 10.53 13 63456 1041 32449016
Migraine 13.01 10.53 58 63411 13927 32436130
Lymphadenopathy 12.98 10.53 94 63375 26988 32423069
Heart rate decreased 12.97 10.53 89 63380 25111 32424946
Aspiration 12.95 10.53 3 63466 11220 32438837
Transplant failure 12.91 10.53 21 63448 2747 32447310
Chronic graft versus host disease in liver 12.89 10.53 8 63461 318 32449739
Muscle rigidity 12.88 10.53 3 63466 11183 32438874
Human ehrlichiosis 12.88 10.53 7 63462 216 32449841
Brain stem syndrome 12.86 10.53 9 63460 439 32449618
Placental disorder 12.80 10.53 5 63464 70 32449987
Fluid retention 12.79 10.53 20 63449 26530 32423527
Hair follicle tumour benign 12.79 10.53 3 63466 5 32450052
Appendicectomy 12.78 10.53 12 63457 891 32449166
Tuberculosis gastrointestinal 12.76 10.53 7 63462 220 32449837
Antiphospholipid syndrome 12.75 10.53 9 63460 445 32449612
Diaphragmatic injury 12.73 10.53 6 63463 136 32449921
Polydipsia 12.72 10.53 25 63444 3792 32446265
Epstein-Barr virus antibody positive 12.64 10.53 8 63461 329 32449728
Pulmonary oedema 12.63 10.53 47 63422 46220 32403837
Alternaria infection 12.60 10.53 8 63461 331 32449726
Hepatitis cholestatic 12.57 10.53 40 63429 8185 32441872
Prostatic specific antigen increased 12.55 10.53 5 63464 13182 32436875
Toxic epidermal necrolysis 12.53 10.53 13 63456 20580 32429477
American trypanosomiasis 12.51 10.53 7 63462 229 32449828
Caesarean section 12.48 10.53 18 63451 2121 32447936
Leiomyosarcoma 12.45 10.53 6 63463 143 32449914
Sacroiliitis 12.44 10.53 13 63456 1099 32448958
Anaplastic large cell lymphoma T- and null-cell types stage III 12.44 10.53 3 63466 6 32450051
Actinic cheilitis 12.44 10.53 3 63466 6 32450051
Leiomyoma 12.44 10.53 3 63466 6 32450051
Gastrooesophageal sphincter insufficiency 12.43 10.53 5 63464 76 32449981
Neuromyelitis optica spectrum disorder 12.41 10.53 6 63463 144 32449913
Intentional product misuse 12.39 10.53 33 63436 36018 32414039
Lymphocyte count 12.37 10.53 5 63464 77 32449980
Oropharyngeal pain 12.36 10.53 104 63365 31248 32418809
Scar 12.25 10.53 32 63437 5861 32444196
Oedema 12.24 10.53 46 63423 45101 32404956
Haematemesis 12.22 10.53 22 63447 27613 32422444
Mycobacterium abscessus infection 12.19 10.53 10 63459 620 32449437
Gastrointestinal stoma output decreased 12.13 10.53 4 63465 33 32450024
Vasculitis necrotising 12.02 10.53 10 63459 632 32449425
Cognitive disorder 12.01 10.53 20 63449 25874 32424183
Vision blurred 11.99 10.53 45 63424 44141 32405916
Eosinophilic myocarditis 11.99 10.53 9 63460 490 32449567
Haemodialysis 11.98 10.53 48 63421 10998 32439059
Death neonatal 11.90 10.53 8 63461 365 32449692
Lip swelling 11.88 10.53 6 63463 13759 32436298
Psoriasis 11.86 10.53 48 63421 46075 32403982
Drug specific antibody 11.83 10.53 7 63462 255 32449802
Diarrhoea 11.82 10.53 587 62882 364215 32085842
Product administration error 11.80 10.53 8 63461 15617 32434440
Laparotomy 11.78 10.53 7 63462 257 32449800
Bacillary angiomatosis 11.71 10.53 5 63464 89 32449968
Short-bowel syndrome 11.70 10.53 7 63462 260 32449797
Blood sodium decreased 11.70 10.53 9 63460 16465 32433592
Focal segmental glomerulosclerosis 11.66 10.53 17 63452 2023 32448034
Stenotrophomonas infection 11.63 10.53 16 63453 1804 32448253
Adenocarcinoma 11.56 10.53 16 63453 1815 32448242
Rhegmatogenous retinal detachment 11.54 10.53 4 63465 39 32450018
Xanthoma 11.51 10.53 5 63464 93 32449964
Enterostomy 11.46 10.53 5 63464 94 32449963
Rectal stenosis 11.44 10.53 6 63463 172 32449885
Alanine aminotransferase increased 11.44 10.53 98 63371 78381 32371676
Blood pressure decreased 11.42 10.53 56 63413 51024 32399033
Congenital arterial malformation 11.41 10.53 5 63464 95 32449962
Neoplasm progression 11.31 10.53 13 63456 19645 32430412
Hypogammaglobulinaemia 11.30 10.53 32 63437 6144 32443913
Haemoptysis 11.29 10.53 31 63438 33494 32416563
Polychondritis 11.28 10.53 6 63463 177 32449880
Diabetic ketoacidosis 11.28 10.53 11 63458 17921 32432136
Angina unstable 11.25 10.53 5 63464 12350 32437707
Opportunistic infection 11.25 10.53 15 63454 1642 32448415
Proteinuria 11.24 10.53 65 63404 17290 32432767
Iron deficiency anaemia 11.21 10.53 43 63426 9658 32440399
Enterocolonic fistula 11.18 10.53 5 63464 100 32449957
Neurological symptom 11.15 10.53 23 63446 3612 32446445
Leiomyosarcoma metastatic 11.12 10.53 3 63466 11 32450046
Diaphragmatic hernia 11.10 10.53 7 63462 286 32449771
Accidental exposure to product 11.08 10.53 4 63465 11198 32438859
Adverse drug reaction 11.07 10.53 21 63448 25840 32424217
Therapy cessation 11.06 10.53 9 63460 16004 32434053
Anti-myelin-associated glycoprotein antibodies positive 10.92 10.53 3 63466 12 32450045
Pneumonia legionella 10.91 10.53 15 63454 1690 32448367
Bile duct stenosis 10.91 10.53 13 63456 1271 32448786
Withdrawal syndrome 10.89 10.53 5 63464 12117 32437940
Acute respiratory failure 10.89 10.53 25 63444 28703 32421354
Schizophrenia 10.88 10.53 3 63466 9981 32440076
Latent tuberculosis 10.88 10.53 12 63457 1079 32448978
Back pain 10.85 10.53 152 63317 110901 32339156
Restlessness 10.83 10.53 20 63449 24861 32425196
Dyspepsia 10.81 10.53 31 63438 33024 32417033
Renal injury 10.79 10.53 5 63464 12050 32438007
Anastomotic ulcer 10.78 10.53 7 63462 301 32449756
Maternal drugs affecting foetus 10.77 10.53 25 63444 4252 32445805
Mediastinum neoplasm 10.73 10.53 3 63466 13 32450044
Perineal fistula 10.73 10.53 3 63466 13 32450044
Hodgkin's disease nodular sclerosis 10.73 10.53 3 63466 13 32450044
Post transplant distal limb syndrome 10.70 10.53 7 63462 305 32449752
Immunosuppressant drug level decreased 10.67 10.53 13 63456 1300 32448757
Skin laceration 10.67 10.53 49 63420 11917 32438140
Gastroenterostomy 10.65 10.53 4 63465 50 32450007
Anaemia megaloblastic 10.62 10.53 6 63463 200 32449857
Anger 10.56 10.53 5 63464 11899 32438158
Foetal cardiac disorder 10.55 10.53 3 63466 14 32450043
Micrognathia 10.54 10.53 7 63462 313 32449744

Pharmacologic Action:

SourceCodeDescription
ATC L04AX01 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
IMMUNOSUPPRESSANTS
IMMUNOSUPPRESSANTS
Other immunosuppressants
FDA CS M0015066 Nucleosides
FDA CS M0018169 Purines
FDA MoA N0000000233 Nucleic Acid Synthesis Inhibitors
MeSH PA D000963 Antimetabolites
MeSH PA D000964 Antimetabolites, Antineoplastic
MeSH PA D000970 Antineoplastic Agents
MeSH PA D018501 Antirheumatic Agents
MeSH PA D007155 Immunologic Factors
MeSH PA D007166 Immunosuppressive Agents
MeSH PA D009676 Noxae
FDA EPC N0000175712 Purine Antimetabolite

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Refractory idiopathic thrombocytopenic purpura indication 13172003
Relapsing multiple sclerosis indication 24700007 DOID:2377
Crohn's disease indication 34000006
Pemphigus vulgaris indication 49420001 DOID:0060851
Systemic lupus erythematosus indication 55464009 DOID:9074
Ulcerative colitis indication 64766004 DOID:8577
Rheumatoid arthritis indication 69896004 DOID:7148
Bullous pemphigoid indication 77090002 DOID:8506
Myasthenia gravis indication 91637004 DOID:437
Polyarteritis nodosa indication 155441006 DOID:9810
Behcet's disease indication 310701003 DOID:13241
Dermatomyositis indication 396230008 DOID:10223
Autoimmune hepatitis indication 408335007
Refractory autoimmune haemolytic anaemia indication 413603009 DOID:718
Prevention of Kidney Transplant Rejection indication
Polymyositis off-label use 31384009
Prevention of Lung Transplant Rejection off-label use
Prevention of Cardiac Transplant Rejection off-label use
Prevention of Liver Transplant Rejection off-label use
Mycosis contraindication 3218000 DOID:1564
Viral disease contraindication 34014006 DOID:934
Hepatic vein thrombosis contraindication 38739001 DOID:11512
Bacterial infectious disease contraindication 87628006
Malignant lymphoma contraindication 118600007 DOID:0060058
Liver function tests abnormal contraindication 166603001
Acute pancreatitis contraindication 197456007 DOID:2913
Impaired renal function disorder contraindication 197663003
Anemia contraindication 271737000 DOID:2355
Pregnancy, function contraindication 289908002
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Bone marrow depression contraindication 307762000
Hepatosplenic T-cell lymphoma contraindication 445406001
Thiopurine S-Methyltransferase Deficiency contraindication
Severe Leukopenia contraindication
Protozoal Infection contraindication

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.28 acidic
pKa2 3.24 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Multidrug resistance-associated protein 4 Transporter WOMBAT-PK
Ras-related C3 botulinum toxin substrate 1 Enzyme WOMBAT-PK
ATP-binding cassette sub-family G member 2 Transporter WOMBAT-PK
Multidrug resistance-associated protein 5 Transporter WOMBAT-PK
Thiopurine S-methyltransferase Enzyme WOMBAT-PK

External reference:

IDSource
4018766 VUID
N0000147069 NUI
D00238 KEGG_DRUG
55774-33-9 SECONDARY_CAS_RN
1256 RXNORM
C0004482 UMLSCUI
CHEMBL1542 ChEMBL_ID
DB00993 DRUGBANK_ID
CHEMBL1200400 ChEMBL_ID
D001379 MESH_DESCRIPTOR_UI
2265 PUBCHEM_CID
7120 IUPHAR_LIGAND_ID
1291 INN_ID
MRK240IY2L UNII
3341 MMSL
4234 MMSL
4235 MMSL
6041 MMSL
d00024 MMSL
003419 NDDF
004123 NDDF
111165009 SNOMEDCT_US
372574004 SNOMEDCT_US
67221004 SNOMEDCT_US
4018766 VANDF

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Azathioprine Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0143-9566 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 100 mg INTRAVENOUS ANDA 22 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 0378-1005 TABLET 50 mg ORAL ANDA 23 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 21695-484 TABLET 50 mg ORAL ANDA 20 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 33261-758 TABLET 50 mg ORAL ANDA 20 sections
AZATHIOPRINE HUMAN PRESCRIPTION DRUG LABEL 1 42291-071 TABLET 50 mg ORAL ANDA 19 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 43353-745 TABLET 50 mg ORAL ANDA 23 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 51407-182 TABLET 50 mg ORAL ANDA 14 sections
IMURAN HUMAN PRESCRIPTION DRUG LABEL 1 54766-590 TABLET 50 mg ORAL NDA 23 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 54868-5310 TABLET 50 mg ORAL ANDA 20 sections
AZATHIOPRINE HUMAN PRESCRIPTION DRUG LABEL 1 60219-1076 TABLET 50 mg ORAL ANDA 19 sections
AZATHIOPRINE HUMAN PRESCRIPTION DRUG LABEL 1 60219-2036 TABLET 75 mg ORAL ANDA 19 sections
AZATHIOPRINE HUMAN PRESCRIPTION DRUG LABEL 1 60219-2037 TABLET 100 mg ORAL ANDA 19 sections
IMURAN HUMAN PRESCRIPTION DRUG LABEL 1 65483-590 TABLET 50 mg ORAL NDA 23 sections
Azasan HUMAN PRESCRIPTION DRUG LABEL 1 65649-231 TABLET 75 mg ORAL ANDA 13 sections
Azasan HUMAN PRESCRIPTION DRUG LABEL 1 65649-241 TABLET 100 mg ORAL ANDA 13 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 65841-602 TABLET 50 mg ORAL ANDA 1 sections
Azathioprine Human Prescription Drug Label 1 67877-492 TABLET 25 mg ORAL ANDA 21 sections
Azathioprine Human Prescription Drug Label 1 67877-493 TABLET 50 mg ORAL ANDA 21 sections
Azathioprine Human Prescription Drug Label 1 67877-494 TABLET 75 mg ORAL ANDA 21 sections
Azathioprine Human Prescription Drug Label 1 67877-495 TABLET 100 mg ORAL ANDA 21 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 68084-229 TABLET 50 mg ORAL ANDA 20 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 68382-003 TABLET 50 1 ORAL ANDA 20 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 68382-118 TABLET 25 1 ORAL ANDA 20 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 68382-119 TABLET 75 1 ORAL ANDA 20 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 68382-120 TABLET 100 1 ORAL ANDA 20 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 68462-502 TABLET 50 mg ORAL ANDA 14 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 68462-502 TABLET 50 mg ORAL ANDA 14 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 70771-1139 TABLET 25 1 ORAL ANDA 1 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 70771-1140 TABLET 75 1 ORAL ANDA 1 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 70771-1141 TABLET 100 1 ORAL ANDA 1 sections