azathioprine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	269	446-86-6

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: BW 57-322 azathioprine sulfate azathioprine azamune azanin azathioprin azathropine azothioprine azathioprine sodium	Azathioprine is an inactive pro-drug of 6-mercaptopurine (6-MP), which acts as a purine antagonist but requires cellular uptake and intracellular anabolism to thioguanine nucleotides (TGNs) for immunosuppression. TGNs and other metabolites (e.g. 6-methylmercaptopurine ribonucleotides) inhibit de novo purine synthesis and purine nucleotide interconversions. The TGNs are also incorporated into nucleic acids and this contributes to the immunosuppressive effects of the medicinal product. Other potential mechanisms of azathioprine include the inhibition of many pathways in nucleic acid biosynthesis, hence preventing proliferation and activity of cells involved in the immune response (B and T lymphocytes). Because of these mechanisms, the therapeutic effect of azathioprine may be evident only after several weeks or months of treatment. Unlike 6-MP, the activity of the azathioprine metabolite 1-methyl-4-nitro-5-thioimidazole has not been clearly determined. However, compared with 6-MP it appears to modify the activity of azathioprine in several systems. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed) Molecular weight: 277.26 Formula: C9H7N7O2S CLOGP: 0.51 LIPINSKI: 0 HAC: 9 HDO: 1 TPSA: 115.42 ALOGS: -2.41 ROTB: 3 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

BW 57-322
azathioprine sulfate
azathioprine
azamune
azanin
azathioprin
azathropine
azothioprine
azathioprine sodium

Azathioprine is an inactive pro-drug of 6-mercaptopurine (6-MP), which acts as a purine antagonist but requires cellular uptake and intracellular anabolism to thioguanine nucleotides (TGNs) for immunosuppression. TGNs and other metabolites (e.g. 6-methylmercaptopurine ribonucleotides) inhibit de novo purine synthesis and purine nucleotide interconversions. The TGNs are also incorporated into nucleic acids and this contributes to the immunosuppressive effects of the medicinal product. Other potential mechanisms of azathioprine include the inhibition of many pathways in nucleic acid biosynthesis, hence preventing proliferation and activity of cells involved in the immune response (B and T lymphocytes). Because of these mechanisms, the therapeutic effect of azathioprine may be evident only after several weeks or months of treatment. Unlike 6-MP, the activity of the azathioprine metabolite 1-methyl-4-nitro-5-thioimidazole has not been clearly determined. However, compared with 6-MP it appears to modify the activity of azathioprine in several systems. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)

Molecular weight: 277.26
Formula: C9H7N7O2S
CLOGP: 0.51
LIPINSKI: 0
HAC: 9
HDO: 1
TPSA: 115.42
ALOGS: -2.41
ROTB: 3

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
0.15	g	O
0.15	g	P

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	1	Benet LZ, Broccatelli F, Oprea TI
S (Water solubility)	10 mg/mL	Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine)	1 %	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	18.03 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability)	60 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

Date	Agency	Company	Orphan
March 20, 1968	FDA	PROMETHEUS LABS
Feb. 21, 2019	PMDA	ASPEN JAPAN K.K.; MITSUBISHI TANABE PHARMA CORPORATION

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Off label use	561.85	9.62	2357	113539	472069	50017159
Drug ineffective	536.53	9.62	3447	112449	815886	49673342
Blood iron abnormal	527.72	9.62	220	115676	3106	50486122
Exposure during pregnancy	509.36	9.62	958	114938	120057	50369171
Drug intolerance	364.33	9.62	1216	114680	217888	50271340
Colitis ulcerative	337.75	9.62	292	115604	16562	50472666
Treatment failure	314.63	9.62	855	115041	136782	50352446
Premature delivery	255.91	9.62	293	115603	23370	50465858
Cytomegalovirus infection	240.66	9.62	249	115647	17713	50471515
Death	227.62	9.62	246	115650	325133	50164095
Product use in unapproved indication	219.58	9.62	673	115223	115146	50374082
Intestinal stenosis	219.23	9.62	110	115786	2430	50486798
Lupus-like syndrome	195.34	9.62	167	115729	9324	50479904
Cushingoid	194.90	9.62	144	115752	6501	50482727
Fall	192.09	9.62	294	115602	334638	50154590
Condition aggravated	184.24	9.62	1237	114659	295821	50193407
Fistula	178.17	9.62	149	115747	8069	50481159
Bone erosion	176.71	9.62	173	115723	11514	50477714
Demyelination	170.95	9.62	128	115768	5898	50483330
SLE arthritis	165.12	9.62	60	115836	570	50488658
Anal fistula	163.97	9.62	93	115803	2649	50486579
Ileal stenosis	161.06	9.62	75	115821	1397	50487831
Fatigue	160.34	9.62	959	114937	706642	49782586
Drug level below therapeutic	159.28	9.62	102	115794	3638	50485590
Rheumatoid arthritis	152.63	9.62	887	115009	201663	50287565
Premature labour	151.76	9.62	158	115738	11318	50477910
Post transplant lymphoproliferative disorder	150.78	9.62	103	115793	4101	50485127
Therapeutic response decreased	144.24	9.62	328	115568	46903	50442325
Therapeutic product effect incomplete	143.81	9.62	499	115397	91016	50398212
Disease recurrence	140.07	9.62	200	115696	19881	50469347
Frequent bowel movements	139.88	9.62	166	115730	13752	50475476
Crohn's disease	139.78	9.62	103	115793	4630	50484598
Proteinuria	139.57	9.62	181	115715	16416	50472812
Cholestasis of pregnancy	137.48	9.62	62	115834	1069	50488159
Elbow deformity	128.44	9.62	63	115833	1323	50487905
Maternal exposure during pregnancy	127.05	9.62	710	115186	159068	50330160
Intentional product use issue	126.61	9.62	426	115470	76492	50412736
Faecal calprotectin increased	125.93	9.62	72	115824	2083	50487145
Epstein-Barr virus infection	125.74	9.62	114	115782	6883	50482345
Glossodynia	121.89	9.62	56	115840	115513	50373715
Large intestinal stenosis	121.11	9.62	65	115831	1657	50487571
Intestinal resection	119.66	9.62	72	115824	2295	50486933
Hyponatraemia	119.13	9.62	36	115860	96103	50393125
Vasculitis	116.74	9.62	152	115744	13839	50475389
Abortion spontaneous	116.51	9.62	280	115616	41492	50447736
Transplant rejection	115.92	9.62	126	115770	9483	50479745
Confusional state	114.49	9.62	155	115741	185773	50303455
Toxicity to various agents	112.78	9.62	196	115700	212303	50276925
Impaired gastric emptying	111.65	9.62	118	115778	8600	50480628
Product dose omission issue	109.46	9.62	157	115739	183681	50305547
Pre-eclampsia	108.61	9.62	112	115784	7932	50481296
Malignant neoplasm progression	108.35	9.62	14	115882	68110	50421118
Arthritis	107.26	9.62	438	115458	86283	50402945
Somnolence	105.05	9.62	120	115776	154865	50334363
Pain	104.87	9.62	837	115059	578066	49911162
Diffuse large B-cell lymphoma	103.22	9.62	93	115803	5569	50483659
Kidney transplant rejection	102.78	9.62	80	115816	3907	50485321
Anal abscess	101.95	9.62	78	115818	3713	50485515
Haematochezia	98.26	9.62	255	115641	39627	50449601
Haemophagocytic lymphohistiocytosis	96.88	9.62	109	115787	8524	50480704
Hepatic cirrhosis	95.63	9.62	156	115740	17421	50471807
Ankylosing spondylitis	93.58	9.62	98	115798	7067	50482161
Abscess	93.50	9.62	138	115758	14134	50475094
Pemphigus	91.68	9.62	84	115812	120082	50369146
Product use issue	91.51	9.62	621	115275	148854	50340374
Drug abuse	91.19	9.62	14	115882	59832	50429396
Lupus nephritis	89.96	9.62	60	115836	2295	50486933
Drug hypersensitivity	89.90	9.62	924	114972	250086	50239142
Abdominal pain	89.13	9.62	879	115017	235349	50253879
Red blood cell sedimentation rate increased	88.36	9.62	203	115693	29213	50460015
Pancreatitis	87.61	9.62	255	115641	42359	50446869
Therapeutic product effect decreased	87.35	9.62	572	115324	135478	50353750
Inflammation	86.48	9.62	307	115589	56605	50432623
Atrial fibrillation	86.44	9.62	64	115832	101681	50387547
Antinuclear antibody positive	85.90	9.62	88	115808	6184	50483044
Overdose	85.67	9.62	62	115834	99665	50389563
Joint dislocation	84.78	9.62	122	115774	12211	50477017
Electrocardiogram QT prolonged	84.13	9.62	10	115886	51876	50437352
Exostosis	84.13	9.62	118	115778	11535	50477693
Constipation	83.26	9.62	189	115707	185519	50303709
Hypotension	81.42	9.62	272	115624	235197	50254031
Cardiac failure congestive	81.32	9.62	46	115850	84336	50404892
Cytomegalovirus viraemia	81.26	9.62	75	115821	4634	50484594
Cerebrovascular accident	81.15	9.62	59	115837	94621	50394607
Anaphylactic reaction	80.78	9.62	290	115606	53765	50435463
Lung transplant rejection	80.49	9.62	38	115858	731	50488497
Basal cell carcinoma	80.12	9.62	170	115726	23186	50466042
Pancytopenia	79.51	9.62	392	115504	83638	50405590
Swelling	78.74	9.62	219	115677	200653	50288575
Osteoporosis	78.68	9.62	254	115642	44625	50444603
Pleuritic pain	78.36	9.62	85	115811	6381	50482847
Normal newborn	77.69	9.62	86	115810	6605	50482623
Rheumatoid nodule	77.53	9.62	119	115777	12616	50476612
Gestational hypertension	75.00	9.62	52	115844	2121	50487107
Disseminated tuberculosis	74.27	9.62	55	115841	2491	50486737
Squamous cell carcinoma	73.99	9.62	90	115806	7649	50481579
Hepatosplenic T-cell lymphoma	73.92	9.62	33	115863	555	50488673
Diarrhoea haemorrhagic	72.96	9.62	89	115807	7586	50481642
Tremor	72.51	9.62	94	115802	114809	50374419
Joint stiffness	71.81	9.62	191	115705	30117	50459111
Dizziness	70.55	9.62	484	115412	345885	50143343
Arthralgia	70.54	9.62	1402	114494	437300	50051928
Leukopenia	70.39	9.62	324	115572	67204	50422024
Pneumocystis jirovecii pneumonia	70.30	9.62	123	115773	14540	50474688
Asthenia	69.41	9.62	437	115459	318605	50170623
Epstein-Barr virus associated lymphoproliferative disorder	69.30	9.62	45	115851	1644	50487584
Clostridium difficile infection	69.29	9.62	169	115727	25270	50463958
Granulomatosis with polyangiitis	69.09	9.62	46	115850	1754	50487474
Synovial fluid analysis	68.09	9.62	44	115852	1594	50487634
Stomatitis	68.06	9.62	79	115817	101265	50387963
C-reactive protein increased	67.86	9.62	317	115579	66157	50423071
Hypokalaemia	67.71	9.62	61	115835	87931	50401297
Hand deformity	67.41	9.62	78	115818	100121	50389107
Intestinal obstruction	67.37	9.62	171	115725	26212	50463016
Premature baby	67.03	9.62	137	115759	18200	50471028
Hair follicle tumour benign	66.14	9.62	27	115869	360	50488868
Contusion	65.55	9.62	97	115799	112086	50377142
Abdominal discomfort	65.01	9.62	291	115605	231350	50257878
Scleritis	64.81	9.62	56	115840	3171	50486057
Immunosuppressant drug level decreased	64.27	9.62	34	115862	841	50488387
Progressive multifocal leukoencephalopathy	64.12	9.62	103	115793	11354	50477874
Gastrointestinal inflammation	63.83	9.62	65	115831	4535	50484693
Cardio-respiratory arrest	63.53	9.62	22	115874	53870	50435358
Liver function test increased	63.35	9.62	164	115732	25442	50463786
Tenosynovitis stenosans	62.54	9.62	47	115849	2177	50487051
Loss of consciousness	62.17	9.62	89	115807	104264	50384964
Syncope	61.22	9.62	88	115808	102914	50386314
Anti-neutrophil cytoplasmic antibody positive vasculitis	60.74	9.62	47	115849	2275	50486953
Colectomy	60.44	9.62	45	115851	2055	50487173
Febrile neutropenia	59.48	9.62	82	115814	97585	50391643
Blood pressure fluctuation	59.43	9.62	199	115697	35624	50453604
Gastrointestinal lymphoma	59.23	9.62	16	115880	48	50489180
Hypogammaglobulinaemia	58.96	9.62	69	115827	5630	50483598
Insomnia	58.36	9.62	205	115691	174660	50314568
Discomfort	58.31	9.62	99	115797	108281	50380947
Muscle injury	58.11	9.62	8	115888	37103	50452125
Erythema nodosum	57.55	9.62	57	115839	3846	50485382
Intentional overdose	57.50	9.62	36	115860	62468	50426760
Histoplasmosis disseminated	57.07	9.62	36	115860	1250	50487978
Autoimmune hepatitis	57.07	9.62	78	115818	7441	50481787
Diabetes mellitus	56.95	9.62	243	115653	48790	50440438
Wound	56.59	9.62	97	115799	105697	50383531
Decreased appetite	56.00	9.62	253	115643	200670	50288558
Anxiety	54.84	9.62	215	115681	177391	50311837
Lymphoproliferative disorder	53.92	9.62	48	115848	2829	50486399
Pulmonary mass	53.89	9.62	127	115769	18578	50470650
Neutrophil count decreased	53.89	9.62	19	115877	46007	50443221
Caesarean section	53.83	9.62	114	115782	15525	50473703
Overlap syndrome	53.05	9.62	27	115869	615	50488613
Lymphopenia	52.77	9.62	113	115783	15508	50473720
Dyspnoea	52.76	9.62	910	114986	546698	49942530
Ulcer	52.69	9.62	132	115764	20068	50469160
Sedation	51.92	9.62	5	115891	30605	50458623
Pulmonary tuberculosis	51.48	9.62	56	115840	4217	50485011
Lupus vasculitis	50.77	9.62	24	115872	463	50488765
Osteonecrosis	50.43	9.62	139	115757	22378	50466850
Central nervous system lymphoma	50.27	9.62	34	115862	1331	50487897
Hallucination	50.12	9.62	22	115874	46635	50442593
Retinitis	48.94	9.62	38	115858	1849	50487379
Tuberculosis	48.88	9.62	85	115811	9998	50479230
Foot deformity	48.51	9.62	124	115772	19086	50470142
Drug level decreased	48.42	9.62	67	115829	6466	50482762
Premature separation of placenta	48.39	9.62	36	115860	1642	50487586
C-reactive protein abnormal	48.38	9.62	157	115739	27652	50461576
Inappropriate schedule of product administration	47.89	9.62	305	115591	71526	50417702
Balance disorder	47.41	9.62	55	115841	70535	50418693
Interstitial lung disease	47.41	9.62	244	115652	52932	50436296
Cardiac arrest	47.25	9.62	74	115822	83577	50405651
Therapeutic product effect variable	47.09	9.62	30	115866	1060	50488168
Irritable bowel syndrome	46.81	9.62	30	115866	51411	50437817
B-cell lymphoma	46.64	9.62	45	115851	2940	50486288
Seizure	46.53	9.62	128	115768	117746	50371482
Agitation	46.08	9.62	33	115863	53351	50435877
Injection site swelling	45.98	9.62	19	115877	41754	50447474
Listeriosis	45.50	9.62	32	115864	1336	50487892
Immunosuppressant drug level increased	45.43	9.62	45	115851	3037	50486191
Intestinal fistula	45.20	9.62	26	115870	761	50488467
Duodenal ulcer perforation	45.19	9.62	24	115872	45587	50443641
Anal fissure	45.14	9.62	45	115851	3060	50486168
Angiocentric lymphoma	44.83	9.62	23	115873	533	50488695
Platelet count decreased	44.70	9.62	103	115793	100623	50388605
Histoplasmosis	44.70	9.62	35	115861	1724	50487504
Epstein-Barr virus test positive	44.64	9.62	23	115873	538	50488690
Folliculitis	44.56	9.62	17	115879	39208	50450020
Papilloma viral infection	44.46	9.62	31	115865	1276	50487952
Female genital tract fistula	44.09	9.62	48	115848	3618	50485610
Cytomegalovirus colitis	43.98	9.62	36	115860	1891	50487337
Joint swelling	43.78	9.62	797	115099	244489	50244739
Depressed level of consciousness	43.69	9.62	33	115863	51920	50437308
Chronic allograft nephropathy	43.60	9.62	24	115872	644	50488584
Depression	43.31	9.62	213	115683	165210	50324018
Blood glucose increased	43.30	9.62	60	115836	71264	50417964
Renal impairment	43.10	9.62	309	115587	75352	50413876
Impaired work ability	43.04	9.62	96	115800	13544	50475684
Nicotinic acid deficiency	43.03	9.62	12	115884	42	50489186
Suicidal ideation	41.88	9.62	39	115857	55346	50433882
Neoplasm progression	41.82	9.62	8	115888	29149	50460079
Premature rupture of membranes	41.74	9.62	52	115844	4528	50484700
Injection site erythema	41.65	9.62	67	115829	74869	50414359
Back pain	41.54	9.62	314	115582	219716	50269512
Squamous cell carcinoma of skin	41.25	9.62	55	115841	5123	50484105
Mycobacterial infection	41.09	9.62	32	115864	1564	50487664
Phospholipidosis	40.83	9.62	12	115884	53	50489175
Coma	40.76	9.62	42	115854	56837	50432391
Blister	40.67	9.62	84	115812	85334	50403894
Product label confusion	40.42	9.62	21	115875	500	50488728
Hyperkalaemia	39.86	9.62	31	115865	48058	50441170
Small intestinal obstruction	39.83	9.62	103	115793	15965	50473263
Foetal death	39.71	9.62	69	115827	8111	50481117
Fungal endocarditis	39.42	9.62	16	115880	210	50489018
Bradycardia	39.31	9.62	54	115842	64372	50424856
Muscle fatigue	39.29	9.62	36	115860	2203	50487025
Cholangitis sclerosing	39.14	9.62	28	115868	1201	50488027
Foetal growth restriction	39.04	9.62	61	115835	6566	50482662
Pulmonary fibrosis	38.99	9.62	134	115762	24303	50464925
Feeling abnormal	38.66	9.62	152	115744	125340	50363888
Orthostatic hypotension	38.43	9.62	10	115886	29471	50459757
Epicondylitis	38.08	9.62	33	115863	1876	50487352
Hypoglycaemia	37.90	9.62	40	115856	53541	50435687
Subcutaneous abscess	37.59	9.62	51	115845	4831	50484397
Helicobacter infection	37.58	9.62	35	115861	49667	50439561
Wrong technique in product usage process	37.55	9.62	43	115853	55467	50433761
Clear cell renal cell carcinoma	37.38	9.62	27	115869	1176	50488052
Low birth weight baby	37.28	9.62	56	115840	5825	50483403
Dehydration	37.25	9.62	201	115695	152248	50336980
Bone pain	37.22	9.62	32	115864	47197	50442031
Serotonin syndrome	37.14	9.62	6	115890	24707	50464521
Episcleritis	37.00	9.62	23	115873	778	50488450
Full blood count decreased	36.99	9.62	4	115892	22342	50466886
Injection site inflammation	36.87	9.62	41	115855	3164	50486064
Musculoskeletal stiffness	36.81	9.62	453	115443	128028	50361200
Bronchiectasis	36.60	9.62	76	115820	10207	50479021
Live birth	36.46	9.62	101	115795	16307	50472921
Ileostomy	36.41	9.62	26	115870	1112	50488116
Metabolic acidosis	36.21	9.62	22	115874	38803	50450425
Intentional self-injury	36.14	9.62	5	115891	23107	50466121
Antiphospholipid syndrome	36.01	9.62	29	115867	1488	50487740
Respiratory arrest	35.80	9.62	12	115884	29997	50459231
Proctitis	35.80	9.62	32	115864	1896	50487332
Pneumonia cytomegaloviral	35.61	9.62	32	115864	1909	50487319
Pregnancy	35.44	9.62	148	115748	29429	50459799
Bone marrow failure	35.29	9.62	141	115755	27483	50461745
Panniculitis	35.27	9.62	67	115829	8436	50480792
Intentional product misuse	35.23	9.62	33	115863	46701	50442527
Immunosuppression	35.21	9.62	62	115834	7364	50481864
Intestinal fibrosis	35.18	9.62	13	115883	130	50489098
Disseminated cytomegaloviral infection	35.18	9.62	14	115882	174	50489054
Aphthous ulcer	35.04	9.62	76	115820	10521	50478707
Crepitations	34.92	9.62	56	115840	6163	50483065
Plasmablastic lymphoma	34.89	9.62	14	115882	178	50489050
Palmar-plantar erythrodysaesthesia syndrome	34.85	9.62	3	115893	20095	50469133
Abdominal adhesions	34.48	9.62	37	115859	2743	50486485
Mycobacterium abscessus infection	34.45	9.62	19	115877	512	50488716
Inflammatory bowel disease	34.42	9.62	41	115855	3409	50485819
White blood cell count decreased	34.30	9.62	144	115752	116578	50372650
Injection site bruising	34.06	9.62	21	115875	36747	50452481
Impaired healing	33.75	9.62	68	115828	69718	50419510
Drug specific antibody present	33.56	9.62	40	115856	3328	50485900
Chronic obstructive pulmonary disease	33.40	9.62	44	115852	53391	50435837
Drug ineffective for unapproved indication	33.35	9.62	116	115780	21165	50468063
Nodular regenerative hyperplasia	33.34	9.62	15	115881	257	50488971
Secondary immunodeficiency	33.17	9.62	25	115871	1163	50488065
Liver transplant rejection	33.15	9.62	26	115870	1284	50487944
Dermatomyositis	32.68	9.62	32	115864	2129	50487099
Neuropathy peripheral	32.54	9.62	113	115783	96644	50392584
Colitis	32.42	9.62	174	115722	38355	50450873
Foetal exposure during pregnancy	32.08	9.62	136	115760	27223	50462005
Nausea	31.95	9.62	1307	114589	704091	49785137
Multiple sclerosis relapse	31.61	9.62	31	115865	42933	50446295
Natural killer-cell leukaemia	31.61	9.62	11	115885	91	50489137
Heart transplant rejection	31.54	9.62	17	115879	437	50488791
Enterocutaneous fistula	31.05	9.62	24	115872	1160	50488068
Uveitis	31.04	9.62	67	115829	9243	50479985
Cervical dysplasia	30.97	9.62	35	115861	2750	50486478
Suicide attempt	30.92	9.62	44	115852	51688	50437540
Pyoderma gangrenosum	30.50	9.62	35	115861	2796	50486432
Hyperhidrosis	30.37	9.62	104	115792	89322	50399906
Mycobacterium avium complex infection	30.21	9.62	33	115863	2497	50486731
Coombs positive haemolytic anaemia	30.20	9.62	15	115881	324	50488904
Restlessness	30.14	9.62	10	115886	25163	50464065
Renal mass	30.13	9.62	29	115867	1889	50487339
Red blood cell sedimentation rate abnormal	30.00	9.62	94	115802	16249	50472979
Drug withdrawal syndrome	29.97	9.62	10	115886	25071	50464157
Trichodysplasia spinulosa	29.94	9.62	17	115879	485	50488743
Myositis	29.93	9.62	60	115836	7860	50481368
Eye infection toxoplasmal	29.81	9.62	14	115882	266	50488962
Accidental exposure to product	29.72	9.62	8	115888	23049	50466179
Bronchitis	29.68	9.62	130	115766	104029	50385199
Drug tolerance	29.59	9.62	46	115850	4930	50484298
Meningitis cryptococcal	29.57	9.62	23	115873	1122	50488106
Jaw fracture	29.37	9.62	32	115864	2414	50486814
Scleroderma renal crisis	29.25	9.62	14	115882	278	50488950
Rhegmatogenous retinal detachment	29.25	9.62	10	115886	78	50489150
Chorioretinopathy	29.06	9.62	20	115876	806	50488422
Adverse reaction	28.87	9.62	62	115834	8524	50480704
Device dislocation	28.68	9.62	7	115889	21539	50467689
Synovial cyst	28.65	9.62	60	115836	8106	50481122
Hepatic fibrosis	28.62	9.62	36	115860	3166	50486062
Dyskinesia	28.58	9.62	14	115882	27847	50461381
Acute kidney injury	28.44	9.62	360	115536	227698	50261530
Fluid retention	28.41	9.62	45	115851	50604	50438624
Complications of bone marrow transplant	28.39	9.62	16	115880	450	50488778
Lactic acidosis	28.29	9.62	21	115875	33334	50455894
Extrapulmonary tuberculosis	28.28	9.62	14	115882	300	50488928
Rectal cancer metastatic	28.17	9.62	13	115883	237	50488991
Ganglioneuroma	28.06	9.62	11	115885	131	50489097
Myelosuppression	27.88	9.62	81	115815	13436	50475792
Klebsiella infection	27.78	9.62	55	115841	7139	50482089
Abscess intestinal	27.62	9.62	24	115872	1369	50487859
Laryngeal disorder	27.59	9.62	20	115876	876	50488352
Anogenital warts	27.57	9.62	15	115881	393	50488835
Salmonellosis	27.55	9.62	20	115876	878	50488350
Aspergillus infection	27.38	9.62	53	115843	6768	50482460
Varicella zoster virus infection	27.20	9.62	31	115865	2458	50486770
Neoplasm malignant	27.12	9.62	117	115779	23598	50465630
Rectal abscess	27.06	9.62	21	115875	1021	50488207
Nephrotic syndrome	26.85	9.62	43	115853	4727	50484501
Antinuclear antibody negative	26.76	9.62	12	115884	204	50489024
Abdominal abscess	26.60	9.62	39	115857	3969	50485259
Encephalopathy	26.37	9.62	23	115873	33688	50455540
Kaposi's sarcoma	26.27	9.62	11	115885	157	50489071
Therapeutic reaction time decreased	26.22	9.62	23	115873	1329	50487899
Plasma cell myeloma	26.20	9.62	20	115876	31302	50457926
Nasopharyngitis	26.17	9.62	299	115597	192628	50296600
Strongyloidiasis	26.06	9.62	19	115877	840	50488388
Injury	26.02	9.62	45	115851	48880	50440348
Eosinophilic granulomatosis with polyangiitis	25.99	9.62	27	115869	1928	50487300
Wrist deformity	25.90	9.62	26	115870	1783	50487445
Tractional retinal detachment	25.78	9.62	8	115888	44	50489184
Thiopurine methyltransferase decreased	25.75	9.62	13	115883	291	50488937
Mental status changes	25.74	9.62	27	115869	36245	50452983
Urinary retention	25.62	9.62	14	115882	26176	50463052
Somatic delusion	25.51	9.62	16	115880	550	50488678
Medication error	25.48	9.62	27	115869	36077	50453151
Tuberculosis of central nervous system	25.47	9.62	13	115883	298	50488930
Rectal discharge	25.45	9.62	15	115881	460	50488768
Meningoencephalitis viral	25.43	9.62	13	115883	299	50488929
Congenital osteodystrophy	25.21	9.62	7	115889	24	50489204
Blood calcium decreased	25.19	9.62	8	115888	20698	50468530
Sleep disorder due to general medical condition, insomnia type	25.15	9.62	21	115875	31426	50457802
Serum sickness	25.11	9.62	30	115866	2502	50486726
Drug tolerance decreased	25.10	9.62	61	115835	9099	50480129
Sleep disorder	25.07	9.62	59	115837	57224	50432004
Joint effusion	24.93	9.62	76	115820	12945	50476283
Cardiac failure	24.77	9.62	90	115806	75950	50413278
Hypomagnesaemia	24.74	9.62	11	115885	23145	50466083
Headache	24.72	9.62	930	114966	505605	49983623
Herpes simplex hepatitis	24.63	9.62	13	115883	320	50488908
Abscess rupture	24.59	9.62	12	115884	249	50488979
Intestinal mucosal hypertrophy	24.48	9.62	11	115885	188	50489040
Pneumonia aspiration	24.43	9.62	21	115875	30983	50458245
Renal transplant failure	24.34	9.62	16	115880	597	50488631
Cardiac disorder	24.28	9.62	38	115858	42941	50446287
Product quality issue	24.20	9.62	21	115875	30837	50458391
Antisynthetase syndrome	24.14	9.62	8	115888	56	50489172
Ileectomy	24.12	9.62	10	115886	139	50489089
Colectomy total	24.06	9.62	10	115886	140	50489088
Infectious mononucleosis	23.95	9.62	24	115872	1642	50487586
Bursitis infective	23.95	9.62	21	115875	1213	50488015
Glomerulosclerosis	23.88	9.62	13	115883	341	50488887
Unresponsive to stimuli	23.80	9.62	21	115875	30588	50458640
Flank pain	23.68	9.62	75	115821	13040	50476188
Sopor	23.62	9.62	8	115888	19871	50469357
Injection site pain	23.60	9.62	153	115743	110871	50378357
Lipase increased	23.53	9.62	57	115839	8484	50480744
Varicella	23.38	9.62	24	115872	1690	50487538
Dysgeusia	23.35	9.62	33	115863	38883	50450345
Abdominal pain upper	23.15	9.62	243	115653	159066	50330162
Cognitive disorder	23.08	9.62	41	115855	44082	50445146
Accidental overdose	22.97	9.62	8	115888	19525	50469703
Skin ulcer	22.93	9.62	149	115747	35169	50454059
Arthritis enteropathic	22.91	9.62	11	115885	220	50489008
Peripheral swelling	22.81	9.62	333	115563	205603	50283625
Myasthenia gravis	22.77	9.62	34	115862	3518	50485710
Conjunctivitis	22.74	9.62	85	115811	16060	50473168
HELLP syndrome	22.74	9.62	18	115878	901	50488327
Spinal cord infection	22.53	9.62	15	115881	572	50488656
Tenosynovitis	22.46	9.62	64	115832	10501	50478727
Gastrointestinal haemorrhage	22.45	9.62	89	115807	73232	50415996
Cytomegalovirus hepatitis	22.39	9.62	12	115884	305	50488923
Small intestinal stenosis	22.30	9.62	14	115882	482	50488746
Body temperature fluctuation	22.29	9.62	25	115871	1948	50487280
Hepatosplenomegaly	22.28	9.62	27	115869	2285	50486943
Therapeutic response shortened	22.19	9.62	51	115845	7338	50481890
Oesophageal squamous cell carcinoma	21.98	9.62	9	115887	121	50489107
Intestinal anastomosis	21.97	9.62	12	115884	317	50488911
Myocardial infarction	21.94	9.62	117	115779	88910	50400318
Gastrointestinal stoma output abnormal	21.91	9.62	7	115889	43	50489185
Emotional distress	21.88	9.62	20	115876	28643	50460585
Nocardiosis	21.77	9.62	23	115873	1675	50487553
Anaplastic large cell lymphoma T- and null-cell types	21.77	9.62	7	115889	44	50489184
Corynebacterium infection	21.76	9.62	13	115883	409	50488819
Congenital syphilitic osteochondritis	21.74	9.62	6	115890	20	50489208
T-cell lymphoma	21.48	9.62	15	115881	619	50488609
Proctalgia	21.47	9.62	40	115856	4963	50484265
Primary biliary cholangitis	21.44	9.62	19	115877	1113	50488115
Hydrops foetalis	21.44	9.62	12	115884	333	50488895
Pneumocystis jirovecii infection	21.40	9.62	20	115876	1255	50487973
Porokeratosis	21.40	9.62	9	115887	130	50489098
Vomiting	21.36	9.62	851	115045	459907	50029321
Delirium	21.35	9.62	34	115862	38158	50451070
Skin lesion	21.34	9.62	119	115777	26608	50462620
Femur fracture	21.28	9.62	33	115863	37431	50451797
Disturbance in attention	21.26	9.62	24	115872	31162	50458066
Hepatitis	21.23	9.62	134	115762	31319	50457909
Abnormal faeces	21.16	9.62	36	115860	4160	50485068
Rectal haemorrhage	21.10	9.62	156	115740	38402	50450826
Aplasia pure red cell	21.04	9.62	36	115860	4179	50485049
Antineutrophil cytoplasmic antibody increased	21.01	9.62	7	115889	50	50489178
Candida infection	21	9.62	108	115788	23415	50465813
Oedema peripheral	20.95	9.62	246	115650	157715	50331513
Lymphadenopathy	20.95	9.62	140	115756	33359	50455869
Therapy interrupted	20.86	9.62	10	115886	20142	50469086
Atypical haemolytic uraemic syndrome	20.82	9.62	14	115882	543	50488685
Anorectal disorder	20.79	9.62	21	115875	1451	50487777
Brain abscess	20.76	9.62	23	115873	1768	50487460
Cholesteatoma	20.68	9.62	9	115887	142	50489086
Congenital cytomegalovirus infection	20.65	9.62	5	115891	8	50489220
Small intestine carcinoma	20.48	9.62	12	115884	364	50488864
Fistula of small intestine	20.47	9.62	11	115885	281	50488947
Disorientation	20.40	9.62	31	115865	35453	50453775
Dysplasia	20.32	9.62	15	115881	676	50488552
Renal tubular atrophy	20.30	9.62	14	115882	566	50488662
Fistula discharge	20.28	9.62	17	115879	923	50488305
Sleep apnoea syndrome	20.27	9.62	15	115881	23853	50465375
Appendicitis	20.20	9.62	46	115850	6578	50482650
Anal cancer	20.19	9.62	13	115883	468	50488760
Cerebral toxoplasmosis	20.16	9.62	15	115881	684	50488544
Sebaceous carcinoma	20.15	9.62	6	115890	28	50489200
Lupus myocarditis	20.10	9.62	7	115889	58	50489170
International normalised ratio increased	20.06	9.62	43	115853	43109	50446119
Neuromyelitis optica spectrum disorder	20.05	9.62	16	115880	810	50488418
Cough	20.00	9.62	411	115485	240853	50248375
Infusion related reaction	19.94	9.62	519	115377	169038	50320190
Herpes simplex reactivation	19.87	9.62	12	115884	385	50488843
Actinic keratosis	19.84	9.62	25	115871	2202	50487026
Chronic hepatitis	19.82	9.62	16	115880	824	50488404
Dementia	19.79	9.62	6	115890	15991	50473237
Paraesthesia	19.75	9.62	178	115718	120065	50369163
Gastrointestinal scarring	19.72	9.62	10	115886	226	50489002
Ileostomy closure	19.71	9.62	8	115888	105	50489123
Gestational diabetes	19.70	9.62	49	115847	7416	50481812
Transaminases increased	19.69	9.62	120	115776	27704	50461524
Gastrointestinal fistula	19.62	9.62	12	115884	394	50488834
Pericarditis	19.62	9.62	103	115793	78586	50410642
Granuloma skin	19.55	9.62	42	115854	5776	50483452
Weight decreased	19.43	9.62	653	115243	220592	50268636
Thrombotic microangiopathy	19.42	9.62	54	115842	8737	50480491
Rectal stenosis	19.41	9.62	9	115887	166	50489062
Hyperadrenocorticism	19.37	9.62	11	115885	314	50488914
Blood parathyroid hormone decreased	19.09	9.62	47	115849	7067	50482161
Adverse drug reaction	19.08	9.62	202	115694	55020	50434208
Device issue	19.07	9.62	11	115885	19961	50469267
Trichostasis spinulosa	19.03	9.62	5	115891	13	50489215
Anal ulcer	18.97	9.62	13	115883	520	50488708
Malignant polyp	18.88	9.62	9	115887	177	50489051
External auditory canal atresia	18.86	9.62	7	115889	71	50489157
Poisoning	18.72	9.62	3	115893	12426	50476802
Pruritus	18.52	9.62	501	115395	283067	50206161
Lethargy	18.52	9.62	55	115841	49377	50439851
Sinusitis	18.46	9.62	277	115619	170281	50318947
Malignant melanoma	18.43	9.62	58	115838	10050	50479178
Gastrointestinal wall thickening	18.30	9.62	17	115879	1059	50488169
Ill-defined disorder	18.26	9.62	64	115832	54590	50434638
Transient hypogammaglobulinaemia of infancy	18.23	9.62	6	115890	41	50489187
Underdose	18.21	9.62	12	115884	20266	50468962
Peritonitis	18.17	9.62	77	115819	15409	50473819
Epistaxis	18.10	9.62	80	115816	63874	50425354
Muscle spasms	18.04	9.62	192	115704	125361	50363867
Epstein-Barr virus associated lymphoma	18.04	9.62	12	115884	457	50488771
Vision blurred	17.94	9.62	106	115790	78541	50410687
Pulmonary oedema	17.94	9.62	55	115841	48883	50440345
Hypocalcaemia	17.89	9.62	21	115875	26795	50462433
Rheumatoid lung	17.85	9.62	25	115871	2440	50486788
Anorectal stenosis	17.82	9.62	5	115891	18	50489210
Weber tuning fork test abnormal	17.81	9.62	7	115889	84	50489144
Throat cancer	17.81	9.62	12	115884	467	50488761
Withdrawal syndrome	17.80	9.62	9	115887	17581	50471647
Lung abscess	17.75	9.62	20	115876	1566	50487662
Abortion missed	17.73	9.62	20	115876	1568	50487660
Transient ischaemic attack	17.70	9.62	29	115867	32181	50457047
Eye ulcer	17.66	9.62	10	115886	284	50488944
Hip fracture	17.63	9.62	20	115876	25911	50463317
Creatinine renal clearance decreased	17.60	9.62	3	115893	11878	50477350
Pseudoxanthoma elasticum-like syndrome	17.56	9.62	4	115892	4	50489224
Mitochondrial neurogastrointestinal encephalopathy	17.56	9.62	4	115892	4	50489224
Meningitis listeria	17.56	9.62	12	115884	478	50488750
Drug level abnormal	17.52	9.62	7	115889	88	50489140
Anaplastic large-cell lymphoma	17.38	9.62	7	115889	90	50489138
Bowel movement irregularity	17.37	9.62	32	115864	3936	50485292
Bronchomalacia	17.37	9.62	9	115887	213	50489015
Neutropenia	17.17	9.62	237	115659	147728	50341500
Abnormal behaviour	17.16	9.62	12	115884	19646	50469582
Metastases to bone	17.06	9.62	10	115886	17985	50471243
Pulmonary embolism	16.94	9.62	150	115746	101554	50387674
Retinal injury	16.93	9.62	9	115887	225	50489003
Polyhydramnios	16.89	9.62	22	115874	2003	50487225
Aspergillosis oral	16.80	9.62	6	115890	54	50489174
Gait disturbance	16.80	9.62	242	115654	149763	50339465
Proctectomy	16.80	9.62	6	115890	54	50489174
Carcinoid tumour pulmonary	16.70	9.62	11	115885	412	50488816
Nightmare	16.63	9.62	8	115888	16078	50473150
Defaecation urgency	16.60	9.62	27	115869	3006	50486222
Microsporidia infection	16.57	9.62	9	115887	235	50488993
Oral lichen planus	16.55	9.62	12	115884	526	50488702
Stress at work	16.54	9.62	16	115880	1049	50488179
Enterostomy	16.44	9.62	8	115888	165	50489063
Pancreatitis acute	16.41	9.62	102	115794	23710	50465518
Gingival hypertrophy	16.41	9.62	18	115878	1368	50487860
Metastases to central nervous system	16.38	9.62	3	115893	11279	50477949
Symptom masked	16.33	9.62	13	115883	656	50488572
Palatal ulcer	16.15	9.62	6	115890	61	50489167
Inappropriate antidiuretic hormone secretion	16.13	9.62	5	115891	13138	50476090
Hyperthyroidism	16.12	9.62	4	115892	12171	50477057
Anal squamous cell carcinoma	16.07	9.62	10	115886	339	50488889
Blood glucose decreased	16.05	9.62	11	115885	18200	50471028
Synovitis	16.00	9.62	384	115512	123481	50365747
B-cell unclassifiable lymphoma high grade	15.95	9.62	4	115892	8	50489220
Pulmonary necrosis	15.94	9.62	7	115889	113	50489115
Faecal calprotectin abnormal	15.90	9.62	6	115890	64	50489164
Poor venous access	15.88	9.62	56	115840	10284	50478944
Obstructive airways disorder	15.85	9.62	8	115888	15644	50473584
Squamous cell carcinoma of the tongue	15.83	9.62	10	115886	348	50488880
Pain in extremity	15.82	9.62	490	115406	272375	50216853
American trypanosomiasis	15.81	9.62	6	115890	65	50489163
Injection site warmth	15.76	9.62	6	115890	13860	50475368
Exercise tolerance increased	15.75	9.62	5	115891	30	50489198
Congenital bowing of long bones	15.73	9.62	6	115890	66	50489162
Patent ductus arteriosus	15.72	9.62	30	115866	3790	50485438
Cleft lip and palate	15.71	9.62	10	115886	353	50488875
Muscle spasticity	15.66	9.62	10	115886	17174	50472054
Complex regional pain syndrome	15.62	9.62	21	115875	1972	50487256
Knee arthroplasty	15.62	9.62	37	115859	35809	50453419
Acute respiratory distress syndrome	15.57	9.62	92	115804	21007	50468221
Memory impairment	15.55	9.62	112	115784	79248	50409980
Therapy non-responder	15.52	9.62	182	115714	50840	50438388
Diabetic ketoacidosis	15.48	9.62	11	115885	17861	50471367
Pleural effusion	15.46	9.62	116	115780	81338	50407890
Torsade de pointes	15.45	9.62	4	115892	11831	50477397
Hirsutism	15.44	9.62	15	115881	988	50488240
Fear	15.40	9.62	7	115889	14542	50474686
Tonsillar hypertrophy	15.34	9.62	14	115882	852	50488376
Listeria sepsis	15.29	9.62	12	115884	593	50488635
Lung infiltration	15.25	9.62	66	115830	13327	50475901
Oral pain	15.25	9.62	21	115875	25012	50464216
Irritability	15.24	9.62	26	115870	28400	50460828
Opportunistic infection	15.21	9.62	19	115877	1659	50487569
Coronary artery disease	15.21	9.62	28	115868	29698	50459530
Infertility	15.15	9.62	12	115884	601	50488627
Acute febrile neutrophilic dermatosis	15.12	9.62	24	115872	2618	50486610
Injection site pruritus	15.11	9.62	45	115851	40366	50448862
Superinfection	15.11	9.62	21	115875	2035	50487193
Deep vein thrombosis	15.08	9.62	102	115794	73202	50416026
Retinal toxicity	15.07	9.62	16	115880	1172	50488056
Acne conglobata	15.06	9.62	4	115892	11	50489217
Anterograde amnesia	14.99	9.62	11	115885	491	50488737
Anovulatory cycle	14.86	9.62	7	115889	134	50489094
DNA antibody	14.85	9.62	5	115891	37	50489191
Mucormycosis	14.83	9.62	23	115873	2460	50486768
Dry skin	14.81	9.62	50	115846	43141	50446087
Tonsillitis	14.81	9.62	34	115862	4889	50484339
Mucosal inflammation	14.80	9.62	45	115851	40097	50449131
Head injury	14.78	9.62	20	115876	24000	50465228
Mucous stools	14.77	9.62	25	115871	2877	50486351
Polyomavirus-associated nephropathy	14.76	9.62	18	115878	1534	50487694
Lymphoma	14.75	9.62	52	115844	9549	50479679
Product administration error	14.74	9.62	14	115882	19685	50469543
Steatorrhoea	14.73	9.62	10	115886	394	50488834
Aggression	14.67	9.62	16	115880	21100	50468128
Bulimia nervosa	14.66	9.62	10	115886	397	50488831
Gastrointestinal motility disorder	14.52	9.62	32	115864	4477	50484751
Cutaneous leishmaniasis	14.50	9.62	6	115890	83	50489145
Failed induction of labour	14.44	9.62	9	115887	306	50488922
Pseudomonas infection	14.42	9.62	51	115845	9379	50479849
Tuberous sclerosis complex	14.37	9.62	6	115890	85	50489143
Cervix carcinoma	14.37	9.62	23	115873	2527	50486701
Cranial sutures widening	14.34	9.62	4	115892	14	50489214
Gastrointestinal oedema	14.30	9.62	15	115881	1083	50488145
Hepatitis viral	14.29	9.62	10	115886	414	50488814
Arthropathy	14.29	9.62	265	115631	157641	50331587
Legionella infection	14.21	9.62	10	115886	418	50488810
Pelvic abscess	14.20	9.62	17	115879	1421	50487807
Contraindicated product administered	14.19	9.62	444	115452	148514	50340714
Nervousness	14.19	9.62	26	115870	27625	50461603
Sepsis neonatal	14.16	9.62	10	115886	420	50488808
Pyometra	14.06	9.62	6	115890	90	50489138
Anal stenosis	14.05	9.62	9	115887	321	50488907
Intestinal anastomosis complication	14.04	9.62	8	115888	230	50488998
Melaena	14.02	9.62	25	115871	26839	50462389
Abnormal palmar/plantar creases	14.00	9.62	5	115891	45	50489183
Hypervolaemia	13.97	9.62	23	115873	25476	50463752
Ureteral neoplasm	13.93	9.62	4	115892	16	50489212
Asthma	13.91	9.62	134	115762	89203	50400025
Herpes virus infection	13.90	9.62	33	115863	4848	50484380
Foetal exposure during delivery	13.90	9.62	5	115891	46	50489182
Post procedural diarrhoea	13.89	9.62	7	115889	156	50489072
Atypical mycobacterial infection	13.84	9.62	13	115883	821	50488407
Intestinal operation	13.82	9.62	10	115886	437	50488791
Calciphylaxis	13.79	9.62	23	115873	2615	50486613
Acute myocardial infarction	13.75	9.62	29	115867	29244	50459984
Lymphocytopenia neonatal	13.73	9.62	4	115892	17	50489211
Cytomegalovirus mucocutaneous ulcer	13.73	9.62	4	115892	17	50489211
Upper gastrointestinal haemorrhage	13.72	9.62	10	115886	16025	50473203
Eye infection fungal	13.71	9.62	6	115890	96	50489132
Anastomotic stenosis	13.70	9.62	8	115888	241	50488987
Haematoma	13.69	9.62	31	115865	30479	50458749
Intestinal polyp	13.65	9.62	15	115881	1142	50488086
Microscopic polyangiitis	13.65	9.62	7	115889	162	50489066
Endocarditis noninfective	13.62	9.62	5	115891	49	50489179
Amniotic cavity infection	13.59	9.62	15	115881	1148	50488080
Cytomegalovirus chorioretinitis	13.56	9.62	17	115879	1490	50487738
Pollakiuria	13.55	9.62	21	115875	23830	50465398
Impetigo	13.55	9.62	15	115881	1152	50488076
Muscular dystrophy	13.55	9.62	4	115892	18	50489210
Skin necrosis	13.50	9.62	55	115841	10812	50478416
Microtia	13.50	9.62	9	115887	344	50488884
Conjunctivitis allergic	13.50	9.62	12	115884	706	50488522
Stoma site extravasation	13.49	9.62	8	115888	248	50488980
Muscle rigidity	13.47	9.62	3	115893	9826	50479402
Chorioretinitis	13.39	9.62	10	115886	459	50488769
Heart rate irregular	13.39	9.62	83	115813	19277	50469951
Fasting	13.37	9.62	4	115892	19	50489209
Dyspepsia	13.37	9.62	107	115789	73990	50415238
Dysphonia	13.35	9.62	45	115851	38847	50450381
Hyperglycaemia	13.28	9.62	41	115855	36364	50452864
Upper respiratory tract irritation	13.27	9.62	5	115891	53	50489175
Mediastinal effusion	13.27	9.62	5	115891	53	50489175
Cafe au lait spots	13.20	9.62	4	115892	20	50489208
Urinary incontinence	13.20	9.62	28	115868	28180	50461048
Neoplasm skin	13.18	9.62	14	115882	1026	50488202
Congenital toxoplasmosis	13.17	9.62	3	115893	3	50489225
Injection site mass	13.13	9.62	10	115886	15670	50473558
Glomerulonephritis	13.10	9.62	17	115879	1542	50487686
Blood potassium increased	13.05	9.62	11	115885	16387	50472841
Photophobia	13.05	9.62	68	115828	14819	50474409
Precursor T-lymphoblastic lymphoma/leukaemia	13.04	9.62	4	115892	21	50489207
Fibroadenoma of breast	13.03	9.62	9	115887	365	50488863
Migraine	12.99	9.62	110	115786	75170	50414058
Anaemia macrocytic	12.96	9.62	22	115874	2537	50486691
Hepatitis cholestatic	12.95	9.62	37	115859	6080	50483148
Hepatitis E	12.91	9.62	15	115881	1214	50488014
Device breakage	12.91	9.62	3	115893	9544	50479684
Ejection fraction decreased	12.90	9.62	14	115882	18506	50470722
Therapy cessation	12.87	9.62	25	115871	25986	50463242
Myelitis	12.86	9.62	15	115881	1219	50488009
Kidney fibrosis	12.85	9.62	17	115879	1572	50487656
Lung disorder	12.83	9.62	158	115738	44641	50444587
Anaemia	12.83	9.62	461	115435	251995	50237233
Drug level above therapeutic	12.83	9.62	28	115868	3892	50485336
Lacrimation increased	12.80	9.62	12	115884	16980	50472248
Complications of transplanted kidney	12.80	9.62	20	115876	2153	50487075
Myopathy	12.77	9.62	48	115848	9091	50480137
Product storage error	12.76	9.62	6	115890	12218	50477010
Myasthenia gravis crisis	12.73	9.62	9	115887	379	50488849
Primary effusion lymphoma	12.71	9.62	3	115893	4	50489224
Acinetobacter infection	12.68	9.62	16	115880	1411	50487817
Staphylococcal skin infection	12.66	9.62	12	115884	767	50488461
Hot flush	12.65	9.62	55	115841	44114	50445114
Hypoaesthesia	12.65	9.62	210	115686	127047	50362181
Coloboma	12.65	9.62	5	115891	61	50489167
Transplant dysfunction	12.63	9.62	31	115865	4653	50484575
Epidermodysplasia verruciformis	12.57	9.62	5	115891	62	50489166
Anuria	12.56	9.62	5	115891	11239	50477989
Threatened labour	12.55	9.62	12	115884	775	50488453
Neutrophilic dermatosis	12.54	9.62	6	115890	119	50489109
JC virus infection	12.54	9.62	18	115878	1797	50487431
Lymphocele	12.49	9.62	12	115884	780	50488448
Staphylococcal sepsis	12.48	9.62	40	115856	6996	50482232
Enterococcal sepsis	12.47	9.62	15	115881	1260	50487968
Necrosis	12.40	9.62	31	115865	4705	50484523
Food intolerance	12.37	9.62	21	115875	2423	50486805
Anastomotic complication	12.36	9.62	6	115890	123	50489105
Disease risk factor	12.36	9.62	5	115891	65	50489163
Dysarthria	12.36	9.62	44	115852	37359	50451869
Placental necrosis	12.33	9.62	4	115892	26	50489202
Skin laceration	12.31	9.62	15	115881	18827	50470401
Speech disorder	12.30	9.62	41	115855	35507	50453721
Double stranded DNA antibody positive	12.28	9.62	8	115888	294	50488934
Intra-abdominal fluid collection	12.26	9.62	19	115877	2031	50487197
Necrotising retinitis	12.25	9.62	8	115888	295	50488933
Mucosal necrosis	12.20	9.62	4	115892	27	50489201
Muir-Torre syndrome	12.20	9.62	4	115892	27	50489201
Lacrimal haemorrhage	12.20	9.62	4	115892	27	50489201
Seronegative arthritis	12.18	9.62	19	115877	2042	50487186
Colostomy	12.15	9.62	11	115885	663	50488565
Ventricular tachycardia	12.12	9.62	11	115885	15810	50473418
Encephalitis cytomegalovirus	12.11	9.62	10	115886	532	50488696
Cavernous sinus thrombosis	12.06	9.62	6	115890	130	50489098
Ocular toxicity	12.06	9.62	10	115886	535	50488693
Skin cancer	12.04	9.62	48	115848	9346	50479882
Sciatica	11.98	9.62	87	115809	21295	50467933
Gastrointestinal stoma complication	11.97	9.62	16	115880	1494	50487734
Central nervous system necrosis	11.94	9.62	6	115890	133	50489095
Electrolyte imbalance	11.94	9.62	13	115883	17156	50472072
Depressed mood	11.93	9.62	39	115857	33984	50455244
Bacillary angiomatosis	11.90	9.62	5	115891	72	50489156
Gastritis haemorrhagic	11.90	9.62	15	115881	1322	50487906
Abdominal pain lower	11.89	9.62	88	115808	21668	50467560
Mouth ulceration	11.88	9.62	107	115789	27917	50461311
Tenderness	11.85	9.62	78	115818	18487	50470741
Varicella zoster pneumonia	11.83	9.62	4	115892	30	50489198
Histiocytic necrotising lymphadenitis	11.83	9.62	4	115892	30	50489198
Cholestasis	11.82	9.62	99	115797	25302	50463926
Throat irritation	11.80	9.62	33	115863	30206	50459022
Complications of transplanted lung	11.78	9.62	7	115889	218	50489010
Meningitis aseptic	11.75	9.62	28	115868	4124	50485104
Enteritis	11.72	9.62	39	115857	6956	50482272
Ear pain	11.69	9.62	30	115866	28253	50460975
DNA antibody positive	11.68	9.62	8	115888	320	50488908
Ileal ulcer	11.66	9.62	9	115887	434	50488794
Type 2 diabetes mellitus	11.65	9.62	40	115856	34335	50454893
Cheilitis granulomatosa	11.65	9.62	3	115893	7	50489221
Hypergammaglobulinaemia	11.62	9.62	9	115887	436	50488792
Hallucination, auditory	11.61	9.62	5	115891	10723	50478505
Gastroenteritis norovirus	11.60	9.62	17	115879	1730	50487498
Sepsis	11.57	9.62	392	115504	132533	50356695
Sinus bradycardia	11.57	9.62	8	115888	13175	50476053
Pyoderma	11.55	9.62	7	115889	226	50489002
Limb discomfort	11.55	9.62	24	115872	24333	50464895
Maternal exposure during breast feeding	11.52	9.62	24	115872	3230	50485998
Infective tenosynovitis	11.50	9.62	7	115889	228	50489000
Occult blood	11.48	9.62	14	115882	1193	50488035
Concussion	11.45	9.62	41	115855	7587	50481641
Perirectal abscess	11.44	9.62	12	115884	867	50488361
Haemophilus infection	11.43	9.62	13	115883	1028	50488200
Salmonella bacteraemia	11.39	9.62	6	115890	147	50489081
Cytopenia	11.37	9.62	45	115851	8730	50480498
Delusion	11.32	9.62	5	115891	10564	50478664
Thrombocytopenia	11.32	9.62	215	115681	127458	50361770
Cholecystitis chronic	11.30	9.62	4	115892	9665	50479563
Large intestinal ulcer	11.30	9.62	23	115873	3046	50486182
Respiratory gas exchange disorder	11.29	9.62	8	115888	338	50488890
Hypoglycaemic seizure	11.27	9.62	9	115887	456	50488772
Pulmonary congestion	11.22	9.62	11	115885	15236	50473992
Eye swelling	11.20	9.62	18	115878	20126	50469102
Cervical incompetence	11.19	9.62	10	115886	592	50488636
Anger	11.17	9.62	6	115890	11327	50477901
Myoclonus	11.16	9.62	10	115886	14460	50474768
Blood immunoglobulin M increased	11.15	9.62	7	115889	241	50488987
Metastases to liver	11.14	9.62	18	115878	20086	50469142
Steroid dependence	11.11	9.62	8	115888	347	50488881
Moraxella infection	11.09	9.62	8	115888	348	50488880
Renal cell carcinoma	11.05	9.62	23	115873	3094	50486134
Macular degeneration	11.03	9.62	10	115886	14378	50474850
Hypophagia	11.01	9.62	30	115866	27698	50461530
Mental disorder	11.00	9.62	21	115875	21970	50467258
Haematocrit decreased	10.99	9.62	42	115854	34934	50454294
Granuloma	10.89	9.62	30	115866	4828	50484400
Vascular shunt	10.87	9.62	3	115893	10	50489218
Obliterative bronchiolitis	10.84	9.62	17	115879	1836	50487392
Proctocolectomy	10.83	9.62	4	115892	40	50489188
Proctitis ulcerative	10.80	9.62	7	115889	255	50488973
Intestinal dilatation	10.80	9.62	15	115881	1453	50487775
Stillbirth	10.71	9.62	34	115862	5918	50483310
Small intestinal perforation	10.67	9.62	14	115882	1284	50487944
Tuberculosis of eye	10.65	9.62	3	115893	11	50489217
Hypocomplementaemia	10.64	9.62	6	115890	169	50489059
Neuropsychiatric lupus	10.64	9.62	6	115890	169	50489059
Appendicectomy	10.62	9.62	20	115876	2502	50486726
Laryngeal stenosis	10.58	9.62	11	115885	786	50488442
Neuroendocrine carcinoma metastatic	10.57	9.62	6	115890	171	50489057
Pneumatosis intestinalis	10.55	9.62	18	115878	2085	50487143
Burning sensation	10.50	9.62	61	115835	45385	50443843
Feeling jittery	10.50	9.62	52	115844	11108	50478120
Dermatitis psoriasiform	10.46	9.62	16	115880	1690	50487538
Renal phospholipidosis	10.46	9.62	5	115891	99	50489129
Haemorrhage in pregnancy	10.44	9.62	16	115880	1693	50487535
Pulmonary venous thrombosis	10.44	9.62	3	115893	12	50489216
Leiomyosarcoma metastatic	10.44	9.62	3	115893	12	50489216
Febrile convulsion	10.43	9.62	8	115888	382	50488846
Small intestinal resection	10.43	9.62	8	115888	382	50488846
Muscle twitching	10.38	9.62	12	115884	15419	50473809
Anaphylactic shock	10.30	9.62	19	115877	20136	50469092
Pharyngeal oedema	10.27	9.62	9	115887	13156	50476072
Rectal cancer	10.27	9.62	16	115880	1718	50487510
Intestinal fistula infection	10.25	9.62	3	115893	13	50489215
Hodgkin's disease stage II	10.25	9.62	3	115893	13	50489215
Adjustment disorder with depressed mood	10.25	9.62	21	115875	2793	50486435
Lentigo maligna	10.24	9.62	6	115890	182	50489046
Hyperparathyroidism secondary	10.24	9.62	14	115882	1336	50487892
Central nervous system vasculitis	10.24	9.62	11	115885	817	50488411
Cytomegalovirus test positive	10.23	9.62	20	115876	2572	50486656
Vertigo	10.22	9.62	73	115823	51759	50437469
Rheumatic disorder	10.22	9.62	15	115881	1528	50487700
Metastatic malignant melanoma	10.18	9.62	13	115883	1161	50488067
Amnesia	10.15	9.62	56	115840	42204	50447024
Infected fistula	10.15	9.62	5	115891	106	50489122
Evans syndrome	10.15	9.62	6	115890	185	50489043
Panic attack	10.09	9.62	18	115878	19324	50469904
Febrile infection	10.09	9.62	13	115883	1171	50488057
Incorrect route of product administration	10.08	9.62	17	115879	18649	50470579
Mycetoma mycotic	10.07	9.62	3	115893	14	50489214
Ubiquinone decreased	10.07	9.62	3	115893	14	50489214
Affect lability	10.05	9.62	4	115892	8994	50480234
Hidradenitis	10.03	9.62	17	115879	1958	50487270
Photosensitivity reaction	9.98	9.62	57	115839	12854	50476374
Idiopathic pulmonary fibrosis	9.98	9.62	13	115883	1184	50488044
Bronchostenosis	9.98	9.62	8	115888	408	50488820
Polymyositis	9.95	9.62	15	115881	1565	50487663
Angina pectoris	9.91	9.62	29	115867	26159	50463069
Ischaemic nephropathy	9.90	9.62	3	115893	15	50489213
Spinal cord disorder	9.89	9.62	13	115883	1194	50488034
Blood sodium decreased	9.89	9.62	21	115875	21126	50468102
Renal colic	9.87	9.62	13	115883	1196	50488032
Rash pustular	9.87	9.62	35	115861	6446	50482782
Nail disorder	9.77	9.62	5	115891	9703	50479525
Pouchitis	9.76	9.62	8	115888	421	50488807
Campylobacter infection	9.76	9.62	10	115886	703	50488525
Portal venous gas	9.75	9.62	4	115892	54	50489174
Retinitis viral	9.74	9.62	3	115893	16	50489212
Infective aortitis	9.74	9.62	3	115893	16	50489212
Immune-mediated myositis	9.74	9.62	12	115884	1033	50488195
Iron deficiency anaemia	9.72	9.62	69	115827	16765	50472463
Infective pulmonary exacerbation of cystic fibrosis	9.72	9.62	3	115893	7906	50481322
Scedosporium infection	9.71	9.62	8	115888	424	50488804
Breast adenoma	9.69	9.62	4	115892	55	50489173
Mental impairment	9.68	9.62	8	115888	12036	50477192
Drug specific antibody	9.66	9.62	16	115880	1809	50487419
Butterfly rash	9.65	9.62	13	115883	1223	50488005

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Colitis ulcerative	388.86	10.71	278	64508	12491	29497250
Drug ineffective	355.68	10.71	1651	63135	361519	29148222
Off label use	352.65	10.71	1444	63342	299356	29210385
Drug eruption	272.67	10.71	253	64533	16488	29493253
Hepatosplenic T-cell lymphoma	260.08	10.71	76	64710	346	29509395
Death	257.02	10.71	224	64562	341860	29167881
Post transplant lymphoproliferative disorder	218.18	10.71	141	64645	5352	29504389
Intestinal stenosis	213.24	10.71	97	64689	1791	29507950
Fistula	201.86	10.71	131	64655	5008	29504733
Nodular regenerative hyperplasia	196.88	10.71	69	64717	614	29509127
Cytomegalovirus infection	194.51	10.71	247	64539	22968	29486773
Epstein-Barr virus infection	189.62	10.71	139	64647	6490	29503251
Frequent bowel movements	170.82	10.71	150	64636	9089	29500652
Anal abscess	170.64	10.71	119	64667	5132	29504609
Hypersensitivity	166.68	10.71	362	64424	52541	29457200
Lymphoproliferative disorder	166.57	10.71	90	64696	2437	29507304
Intentional product use issue	166.13	10.71	318	64468	42180	29467561
Product use issue	162.05	10.71	352	64434	51092	29458649
Drug abuse	160.02	10.71	3	64783	79880	29429861
Diffuse large B-cell lymphoma	158.18	10.71	122	64664	6154	29503587
Completed suicide	149.57	10.71	13	64773	90233	29419508
Hepatic function abnormal	148.83	10.71	290	64496	38969	29470772
Ileal stenosis	135.20	10.71	62	64724	1167	29508574
Therapeutic product effect decreased	133.52	10.71	235	64551	29216	29480525
Intestinal obstruction	127.73	10.71	183	64603	19094	29490647
Anal fistula	124.60	10.71	90	64696	4105	29505636
Disseminated tuberculosis	124.10	10.71	68	64718	1894	29507847
Fall	119.78	10.71	127	64659	177051	29332690
Febrile neutropenia	119.76	10.71	48	64738	112192	29397549
Cytomegalovirus colitis	117.25	10.71	71	64715	2398	29507343
Crohn's disease	116.45	10.71	76	64710	2933	29506808
Squamous cell carcinoma	113.86	10.71	126	64660	10125	29499616
Hypotension	112.69	10.71	157	64629	194197	29315544
Disease recurrence	111.24	10.71	155	64631	15759	29493982
Condition aggravated	110.99	10.71	621	64165	145674	29364067
Haemophagocytic lymphohistiocytosis	109.64	10.71	125	64661	10379	29499362
Transplant rejection	108.88	10.71	117	64669	9095	29500646
Product use in unapproved indication	106.39	10.71	424	64362	86451	29423290
Treatment failure	104.23	10.71	242	64544	36697	29473044
Infusion related reaction	103.12	10.71	268	64518	43618	29466123
Toxicity to various agents	102.94	10.71	138	64648	173523	29336218
Urticaria	99.24	10.71	304	64482	54356	29455385
Stomatitis	99.13	10.71	238	64548	36875	29472866
Premature baby	98.65	10.71	153	64633	17127	29492614
Malignant neoplasm progression	98.07	10.71	21	64765	73838	29435903
JC virus infection	96.44	10.71	57	64729	1840	29507901
Large intestinal stenosis	96.11	10.71	51	64735	1330	29508411
Pulmonary tuberculosis	96.10	10.71	78	64708	4237	29505504
Blood pressure fluctuation	94.40	10.71	162	64624	19732	29490009
Inappropriate schedule of product administration	93.84	10.71	261	64525	44211	29465530
Acute febrile neutrophilic dermatosis	93.13	10.71	46	64740	1028	29508713
Progressive multifocal leukoencephalopathy	93.11	10.71	105	64681	8614	29501127
Leukopenia	92.84	10.71	299	64487	54904	29454837
Drug level below therapeutic	92.59	10.71	76	64710	4195	29505546
Pneumocystis jirovecii pneumonia	92.23	10.71	146	64640	16633	29493108
Pancytopenia	91.66	10.71	393	64393	82775	29426966
Cushingoid	90.50	10.71	60	64726	2378	29507363
Faecal calprotectin increased	90.26	10.71	51	64735	1510	29508231
Dizziness	88.77	10.71	176	64610	189508	29320233
Intestinal fistula	86.55	10.71	41	64745	833	29508908
Epstein-Barr virus associated lymphoproliferative disorder	85.17	10.71	51	64735	1687	29508054
Myocardial infarction	85.12	10.71	70	64716	110226	29399515
Somnolence	81.09	10.71	53	64733	93902	29415839
Drug level decreased	80.34	10.71	83	64703	6164	29503577
Drug specific antibody present	78.47	10.71	56	64730	2505	29507236
Basal cell carcinoma	78.00	10.71	136	64650	16774	29492967
Kidney transplant rejection	77.61	10.71	86	64700	6919	29502822
Erythema nodosum	77.51	10.71	39	64747	908	29508833
Tuberculosis	77.42	10.71	87	64699	7109	29502632
Intestinal resection	77.14	10.71	45	64741	1417	29508324
Colitis	74.59	10.71	192	64594	31056	29478685
Epistaxis	74.55	10.71	266	64520	51438	29458303
Acute kidney injury	74.38	10.71	314	64472	264953	29244788
Human herpesvirus 8 infection	72.62	10.71	36	64750	811	29508930
Cardiac failure congestive	71.99	10.71	39	64747	76542	29433199
Small intestinal stenosis	71.07	10.71	29	64757	405	29509336
Squamous cell carcinoma of skin	70.21	10.71	95	64691	9391	29500350
Diarrhoea haemorrhagic	70.11	10.71	75	64711	5799	29503942
Abdominal pain	67.88	10.71	518	64268	134839	29374902
Coombs positive haemolytic anaemia	67.57	10.71	33	64753	719	29509022
Dyspnoea	67.28	10.71	430	64356	326302	29183439
Pemphigus	67.10	10.71	38	64748	1130	29508611
Gastrointestinal inflammation	66.20	10.71	54	64732	2954	29506787
Epidermodysplasia verruciformis	65.63	10.71	20	64766	108	29509633
Intentional overdose	65.32	10.71	5	64781	38523	29471218
Abscess	65.13	10.71	93	64693	9669	29500072
Confusional state	64.76	10.71	113	64673	127764	29381977
Bradycardia	63.79	10.71	32	64754	65597	29444144
Clear cell renal cell carcinoma	63.70	10.71	35	64751	980	29508761
Nocardiosis	62.41	10.71	54	64732	3206	29506535
Cytomegalovirus viraemia	62.24	10.71	73	64713	6247	29503494
T-cell lymphoma	61.93	10.71	33	64753	868	29508873
Muscle spasms	61.53	10.71	294	64492	64788	29444953
Atrial fibrillation	61.46	10.71	85	64701	105561	29404180
Immunosuppression	60.47	10.71	66	64720	5220	29504521
Therapeutic response shortened	60.43	10.71	63	64723	4728	29505013
Meningitis listeria	60.33	10.71	25	64761	364	29509377
Herpes zoster	60.07	10.71	173	64613	29879	29479862
Night sweats	59.85	10.71	113	64673	14819	29494922
Lung transplant rejection	59.79	10.71	30	64756	694	29509047
Product dose omission issue	59.70	10.71	74	64712	96309	29413432
Non-cirrhotic portal hypertension	59.29	10.71	22	64764	234	29509507
B-cell lymphoma	58.86	10.71	56	64730	3762	29505979
Lymphopenia	58.75	10.71	106	64680	13427	29496314
Lymphadenitis	58.33	10.71	39	64747	1568	29508173
Colectomy	58.25	10.71	38	64748	1465	29508276
Renal cell carcinoma	57.89	10.71	61	64725	4635	29505106
Hand deformity	57.18	10.71	43	64743	2087	29507654
Abdominal adhesions	57.16	10.71	35	64751	1206	29508535
Drug intolerance	55.87	10.71	232	64554	48147	29461594
Histoplasmosis disseminated	54.58	10.71	33	64753	1111	29508630
Hyponatraemia	54.57	10.71	41	64745	67592	29442149
Overdose	54.07	10.71	57	64729	79762	29429979
Epstein-Barr virus test positive	54.01	10.71	25	64761	481	29509260
Epstein-Barr virus associated lymphoma	53.76	10.71	26	64760	554	29509187
Cardiac arrest	53.75	10.71	65	64721	85526	29424215
Dehydration	53.14	10.71	107	64679	114641	29395100
Kaposi's sarcoma	52.11	10.71	29	64757	833	29508908
Heart transplant rejection	51.84	10.71	32	64754	1119	29508622
Cytomegalovirus enteritis	51.13	10.71	23	64763	413	29509328
Intestinal perforation	50.98	10.71	75	64711	8011	29501730
Haematochezia	50.52	10.71	187	64599	36796	29472945
Transplant dysfunction	50.48	10.71	41	64745	2229	29507512
Cardio-respiratory arrest	50.18	10.71	24	64762	50577	29459164
Neuropathy peripheral	48.92	10.71	50	64736	70977	29438764
Small intestinal obstruction	48.86	10.71	96	64690	12965	29496776
Defaecation urgency	48.49	10.71	36	64750	1713	29508028
Decreased appetite	48.49	10.71	160	64626	145182	29364559
Portal hypertension	47.89	10.71	48	64738	3438	29506303
Pneumonia aspiration	47.62	10.71	11	64775	36726	29473015
Chronic allograft nephropathy	47.57	10.71	30	64756	1090	29508651
Syncope	46.78	10.71	66	64720	81305	29428436
Lymphoma	46.57	10.71	80	64706	9748	29499993
Polyhydramnios	45.84	10.71	18	64768	226	29509515
Rebound effect	45.83	10.71	37	64749	1994	29507747
Anal fissure	44.84	10.71	42	64744	2766	29506975
Blood glucose increased	44.77	10.71	38	64748	58946	29450795
Loss of consciousness	43.63	10.71	59	64727	73997	29435744
Pain in extremity	43.26	10.71	400	64386	110033	29399708
Weight decreased	42.83	10.71	512	64274	150393	29359348
Peliosis hepatis	42.71	10.71	12	64774	46	29509695
Acute myocardial infarction	42.20	10.71	27	64759	48411	29461330
Aggression	41.62	10.71	13	64773	35528	29474213
Lymphocytopenia neonatal	41.55	10.71	9	64777	6	29509735
Aspergillus infection	41.07	10.71	79	64707	10502	29499239
Extrapulmonary tuberculosis	40.96	10.71	13	64773	82	29509659
Clostridium difficile infection	40.40	10.71	101	64685	16040	29493701
Delirium	40.12	10.71	18	64768	39379	29470362
Histoplasmosis	40.06	10.71	29	64757	1327	29508414
Rash	39.87	10.71	248	64538	189571	29320170
Rheumatoid factor negative	39.75	10.71	24	64762	806	29508935
Chronic obstructive pulmonary disease	39.74	10.71	20	64766	40935	29468806
Hypoglycaemia	39.39	10.71	29	64757	48317	29461424
Cholangitis sclerosing	38.98	10.71	26	64760	1041	29508700
Insomnia	38.37	10.71	86	64700	88675	29421066
Neuroendocrine carcinoma of the skin	37.87	10.71	21	64765	599	29509142
Plasma cell myeloma	37.73	10.71	17	64769	37098	29472643
Arthralgia	37.56	10.71	469	64317	139148	29370593
Therapeutic product effect incomplete	37.44	10.71	178	64608	39127	29470614
Bronchopulmonary aspergillosis	37.15	10.71	83	64703	12261	29497480
International normalised ratio increased	36.96	10.71	26	64760	44346	29465395
Candida infection	36.78	10.71	94	64692	15131	29494610
Cutaneous T-cell lymphoma	36.71	10.71	27	64759	1266	29508475
Rectal abscess	36.68	10.71	24	64762	930	29508811
Abnormal behaviour	36.52	10.71	4	64782	23123	29486618
Abscess intestinal	36.40	10.71	28	64758	1406	29508335
Infection reactivation	36.17	10.71	25	64761	1062	29508679
Rectal fissure	36.15	10.71	16	64770	276	29509465
Mycobacterial infection	36.04	10.71	31	64755	1825	29507916
Varicella zoster virus infection	35.82	10.71	28	64758	1440	29508301
Coma	35.74	10.71	21	64765	39429	29470312
Pancreatitis	35.60	10.71	160	64626	34354	29475387
Cerebrovascular accident	35.34	10.71	72	64714	76839	29432902
Mycoplasma infection	35.33	10.71	16	64770	292	29509449
Respiratory arrest	34.98	10.71	7	64779	25826	29483915
Lymphocyte count abnormal	34.94	10.71	20	64766	607	29509134
Electrocardiogram QT prolonged	34.53	10.71	18	64768	36119	29473622
Pyrexia	34.34	10.71	848	63938	286774	29222967
Wrong technique in product usage process	34.20	10.71	13	64773	31415	29478326
Inflammatory bowel disease	33.93	10.71	33	64753	2278	29507463
Oedema peripheral	33.82	10.71	115	64671	103442	29406299
Asthenia	33.43	10.71	306	64480	214944	29294797
Cardiac failure	33.32	10.71	78	64708	79209	29430532
Enterocutaneous fistula	33.25	10.71	21	64765	765	29508976
Visceral leishmaniasis	32.95	10.71	18	64768	498	29509243
Low birth weight baby	32.91	10.71	55	64731	6553	29503188
Actinic keratosis	32.82	10.71	41	64745	3745	29505996
Hypokalaemia	32.71	10.71	37	64749	50166	29459575
Lupus-like syndrome	32.65	10.71	32	64754	2230	29507511
Gastrointestinal disorder	32.61	10.71	137	64649	28569	29481172
Hallucination	32.49	10.71	30	64756	44682	29465059
Intestinal fibrosis	32.41	10.71	11	64775	88	29509653
Drug level above therapeutic	32.20	10.71	38	64748	3272	29506469
Red blood cell sedimentation rate abnormal	32.17	10.71	32	64754	2271	29507470
Gastrointestinal haemorrhage	32.03	10.71	80	64706	79453	29430288
Bone marrow failure	31.96	10.71	132	64654	27317	29482424
Vasculitis	31.77	10.71	60	64726	7868	29501873
Herpes simplex	31.76	10.71	46	64740	4844	29504897
Foetal growth restriction	31.41	10.71	40	64746	3726	29506015
Splenomegaly	31.06	10.71	81	64705	13198	29496543
Obliterative bronchiolitis	31.00	10.71	23	64763	1093	29508648
Abdominal abscess	30.92	10.71	40	64746	3784	29505957
Orthostatic hypotension	30.92	10.71	6	64780	22623	29487118
Neutrophil count decreased	30.75	10.71	30	64756	43537	29466204
Therapeutic response decreased	30.50	10.71	121	64665	24590	29485151
Urinary retention	30.31	10.71	16	64770	31882	29477859
Cystitis escherichia	29.98	10.71	12	64774	159	29509582
Anxiety	29.81	10.71	92	64694	85273	29424468
Fistula discharge	29.75	10.71	16	64770	429	29509312
Rectal haemorrhage	29.72	10.71	152	64634	34397	29475344
Gastrointestinal fistula	29.70	10.71	15	64771	352	29509389
Fatigue	29.39	10.71	503	64283	316318	29193423
Agitation	29.09	10.71	42	64744	51262	29458479
Balance disorder	29.07	10.71	22	64764	36148	29473593
Depressed level of consciousness	29.02	10.71	23	64763	36919	29472822
Nephropathy toxic	28.72	10.71	69	64717	10687	29499054
Heart rate irregular	28.65	10.71	78	64708	13039	29496702
Drug resistance	28.64	10.71	108	64678	21432	29488309
Cow pox	28.61	10.71	8	64778	30	29509711
Gastrointestinal lymphoma	28.61	10.71	8	64778	30	29509711
Myopathy	28.59	10.71	68	64718	10465	29499276
Lung neoplasm	28.44	10.71	41	64745	4299	29505442
Complications of transplanted kidney	28.35	10.71	39	64747	3915	29505826
Granulomatosis with polyangiitis	28.19	10.71	20	64766	886	29508855
Unresponsive to stimuli	28.00	10.71	10	64776	25116	29484625
Enteritis	27.96	10.71	52	64734	6739	29503002
Angina pectoris	27.93	10.71	13	64773	27837	29481904
Gastrointestinal wall thickening	27.90	10.71	22	64764	1146	29508595
Accidental overdose	27.89	10.71	3	64783	17590	29492151
Foetal exposure during pregnancy	27.75	10.71	147	64639	33720	29476021
Hospitalisation	27.73	10.71	36	64750	45952	29463789
Herpes zoster meningoencephalitis	27.72	10.71	13	64773	258	29509483
Limb deformity	27.71	10.71	16	64770	494	29509247
Mycobacterium chelonae infection	27.63	10.71	17	64769	591	29509150
White blood cell count decreased	27.60	10.71	92	64694	83270	29426471
Contusion	27.54	10.71	17	64769	31078	29478663
Pouchitis	27.50	10.71	17	64769	596	29509145
Disease progression	27.40	10.71	90	64696	81826	29427915
Scleroderma	27.32	10.71	23	64763	1315	29508426
Chronic gastrointestinal bleeding	27.09	10.71	13	64773	272	29509469
Dysgeusia	27.08	10.71	8	64778	22666	29487075
Listeria sepsis	27.06	10.71	11	64775	152	29509589
Cytomegalovirus infection reactivation	26.91	10.71	35	64751	3329	29506412
Intestinal anastomosis	26.91	10.71	12	64774	211	29509530
Liver transplant rejection	26.78	10.71	27	64759	1947	29507794
Seizure	26.75	10.71	109	64677	93014	29416727
Hepatitis	26.64	10.71	103	64683	20680	29489061
Papilloma viral infection	26.58	10.71	15	64771	443	29509298
Plasmablastic lymphoma	26.50	10.71	12	64774	219	29509522
Legionella infection	26.49	10.71	15	64771	446	29509295
Acquired gene mutation	26.46	10.71	22	64764	1236	29508505
Gait disturbance	26.36	10.71	78	64708	73271	29436470
Disorientation	26.33	10.71	16	64770	29499	29480242
Diffuse large B-cell lymphoma stage IV	26.16	10.71	12	64774	226	29509515
Eosinophilic bronchitis	26.13	10.71	11	64775	167	29509574
Tachycardia	26.02	10.71	77	64709	72333	29437408
Malignant melanoma	26.02	10.71	52	64734	7109	29502632
Congenital cytomegalovirus infection	25.74	10.71	7	64779	23	29509718
Myasthenia gravis crisis	25.61	10.71	15	64771	476	29509265
Myasthenic syndrome	25.45	10.71	14	64772	393	29509348
Ileostomy	25.44	10.71	15	64771	482	29509259
Complications of transplanted lung	25.44	10.71	11	64775	179	29509562
Graft versus host disease in lung	25.32	10.71	15	64771	486	29509255
Squamous cell carcinoma of the tongue	25.14	10.71	12	64774	248	29509493
Constipation	25.05	10.71	147	64639	114013	29395728
Strongyloidiasis	24.95	10.71	28	64758	2284	29507457
Molluscum contagiosum	24.76	10.71	12	64774	257	29509484
Transient ischaemic attack	24.70	10.71	10	64776	23260	29486481
Irritability	24.37	10.71	9	64777	22143	29487598
Periumbilical abscess	24.37	10.71	8	64778	57	29509684
Hepatosplenomegaly	24.19	10.71	35	64751	3682	29506059
Dyskinesia	24.10	10.71	7	64779	20054	29489687
Intestinal mass	24.08	10.71	14	64772	438	29509303
Epstein Barr virus positive mucocutaneous ulcer	23.82	10.71	12	64774	280	29509461
Body temperature fluctuation	23.76	10.71	22	64764	1428	29508313
Peritoneal abscess	23.68	10.71	8	64778	63	29509678
Meningitis cryptococcal	23.64	10.71	26	64760	2074	29507667
Steroid dependence	23.59	10.71	12	64774	286	29509455
Varicella	23.59	10.71	22	64764	1441	29508300
Hypocalcaemia	23.41	10.71	8	64778	20657	29489084
Phaeohyphomycosis	23.38	10.71	17	64769	783	29508958
Therapeutic reaction time decreased	23.37	10.71	16	64770	669	29509072
Osteonecrosis of jaw	23.37	10.71	4	64782	16506	29493235
Tonsil cancer	23.24	10.71	18	64768	913	29508828
Non-Hodgkin's lymphoma	23.16	10.71	22	64764	1475	29508266
Chronic myeloid leukaemia	22.99	10.71	25	64761	1969	29507772
Hydrops foetalis	22.98	10.71	11	64775	229	29509512
Lung abscess	22.75	10.71	27	64759	2339	29507402
Lupus nephritis	22.68	10.71	11	64775	236	29509505
Eosinophilic granulomatosis with polyangiitis	22.65	10.71	21	64765	1365	29508376
Systemic lupus erythematosus	22.58	10.71	28	64758	2538	29507203
Bone erosion	22.52	10.71	29	64757	2731	29507010
C-reactive protein increased	22.45	10.71	170	64616	44093	29465648
Intestinal anastomosis complication	22.30	10.71	9	64777	122	29509619
Product prescribing error	22.10	10.71	6	64780	17970	29491771
Listeria encephalitis	22.08	10.71	7	64779	44	29509697
Mucosal inflammation	22.01	10.71	22	64764	31573	29478168
Pulmonary vasculitis	21.91	10.71	9	64777	128	29509613
Cytomegalovirus chorioretinitis	21.82	10.71	31	64755	3207	29506534
Subcutaneous abscess	21.79	10.71	32	64754	3412	29506329
Stiff person syndrome	21.74	10.71	8	64778	83	29509658
Narcotic bowel syndrome	21.66	10.71	9	64777	132	29509609
Herpes simplex hepatitis	21.57	10.71	8	64778	85	29509656
Growth retardation	21.51	10.71	22	64764	1614	29508127
Stevens-Johnson syndrome	21.26	10.71	5	64781	16492	29493249
Metabolic acidosis	21.18	10.71	31	64755	37631	29472110
Viral infection	21.15	10.71	76	64710	14734	29495007
Cutaneous leishmaniasis	21.12	10.71	10	64776	203	29509538
Myasthenia gravis	20.99	10.71	30	64756	3121	29506620
Congenital oesophageal anomaly	20.93	10.71	8	64778	93	29509648
Oesophageal atresia	20.92	10.71	13	64773	460	29509281
Hyperkalaemia	20.84	10.71	67	64719	61325	29448416
Pyoderma gangrenosum	20.76	10.71	18	64768	1071	29508670
Subdural haematoma	20.69	10.71	7	64779	18186	29491555
Coronary artery disease	20.60	10.71	41	64745	44149	29465592
Osteoporosis	20.55	10.71	61	64725	10708	29499033
Laryngeal mass	20.41	10.71	6	64780	28	29509713
Congenital cystic lung	20.39	10.71	10	64776	220	29509521
Lymphocytic infiltration	20.33	10.71	14	64772	591	29509150
Heart rate decreased	20.32	10.71	108	64678	24804	29484937
Combined immunodeficiency	20.30	10.71	7	64779	59	29509682
Angioedema	20.27	10.71	24	64762	31891	29477850
Immunosuppressant drug level increased	20.27	10.71	37	64749	4728	29505013
Suicide attempt	20.26	10.71	27	64759	34083	29475658
Rhabdomyolysis	20.20	10.71	67	64719	60741	29449000
Haemolysis	20.07	10.71	46	64740	6910	29502831
Ileal ulcer	19.63	10.71	13	64773	514	29509227
Gastrointestinal stoma complication	19.62	10.71	18	64768	1154	29508587
Hepatic enzyme increased	19.56	10.71	134	64652	33665	29476076
Odynophagia	19.53	10.71	36	64750	4634	29505107
Paracoccidioides infection	19.43	10.71	7	64779	68	29509673
Central nervous system lesion	19.31	10.71	40	64746	5608	29504133
Amnesia	19.20	10.71	13	64773	22630	29487111
Iron deficiency	19.12	10.71	28	64758	2977	29506764
Autoimmune haemolytic anaemia	19.12	10.71	32	64754	3816	29505925
Cytomegalovirus test positive	19.10	10.71	30	64756	3393	29506348
Gastrointestinal mucosa hyperaemia	19.05	10.71	10	64776	255	29509486
Cytokine release syndrome	18.97	10.71	3	64783	13116	29496625
Large intestinal ulcer	18.96	10.71	21	64765	1688	29508053
Gastrointestinal stenosis	18.90	10.71	7	64779	74	29509667
Mucocutaneous leishmaniasis	18.82	10.71	7	64779	75	29509666
Hypersensitivity vasculitis	18.81	10.71	29	64757	3228	29506513
Gallbladder polyp	18.78	10.71	11	64775	349	29509392
Cardiac disorder	18.76	10.71	33	64753	37230	29472511
Granuloma	18.72	10.71	25	64761	2439	29507302
Autoimmune neutropenia	18.70	10.71	10	64776	265	29509476
Anal cancer	18.67	10.71	11	64775	353	29509388
Pneumonia cytomegaloviral	18.55	10.71	26	64760	2656	29507085
Chorioretinopathy	18.54	10.71	19	64767	1397	29508344
Episcleritis	18.51	10.71	8	64778	130	29509611
Full blood count decreased	18.45	10.71	6	64780	15986	29493755
Retinal scar	18.40	10.71	10	64776	274	29509467
Herpes simplex test positive	18.22	10.71	9	64777	201	29509540
Hodgkin's disease	18.13	10.71	15	64771	837	29508904
Pseudopolyp	18.10	10.71	9	64777	204	29509537
Pancreatitis acute	18.07	10.71	103	64683	24282	29485459
Diabetes mellitus	18.02	10.71	149	64637	39682	29470059
Pneumatosis intestinalis	18.00	10.71	28	64758	3141	29506600
Polyomavirus-associated nephropathy	17.90	10.71	29	64757	3367	29506374
Blood creatine phosphokinase increased	17.86	10.71	39	64747	40605	29469136
Pulmonary granuloma	17.74	10.71	18	64768	1308	29508433
Butterfly rash	17.54	10.71	7	64779	92	29509649
Gastroenteritis clostridial	17.52	10.71	9	64777	219	29509522
Arthritis	17.45	10.71	104	64682	24915	29484826
Chest pain	17.42	10.71	159	64627	111814	29397927
Haematuria	17.29	10.71	45	64741	44094	29465647
Relapsing fever	17.28	10.71	8	64778	154	29509587
Brain abscess	17.28	10.71	25	64761	2630	29507111
Disturbance in attention	17.25	10.71	13	64773	21411	29488330
Rectal cancer	17.22	10.71	21	64765	1871	29507870
Erectile dysfunction	17.16	10.71	9	64777	18000	29491741
Aspartate aminotransferase increased	17.08	10.71	70	64716	59655	29450086
Drug specific antibody absent	17.06	10.71	6	64780	54	29509687
Weight increased	17.06	10.71	249	64537	76418	29433323
Drug ineffective for unapproved indication	17.05	10.71	69	64717	14145	29495596
Platelet count decreased	17.00	10.71	147	64639	104525	29405216
Cytomegalovirus duodenitis	16.96	10.71	6	64780	55	29509686
Depression	16.93	10.71	113	64673	85034	29424707
Intestinal ulcer	16.92	10.71	14	64772	781	29508960
Lactic acidosis	16.91	10.71	25	64761	30222	29479519
Laser therapy	16.85	10.71	4	64782	6	29509735
Intestinal diaphragm disease	16.78	10.71	9	64777	240	29509501
Serum sickness	16.74	10.71	20	64766	1745	29507996
Cryptococcosis	16.70	10.71	21	64765	1931	29507810
Hyperglycaemia	16.69	10.71	31	64755	34256	29475485
Oesophagopleural fistula	16.68	10.71	6	64780	58	29509683
Splenic embolism	16.65	10.71	8	64778	168	29509573
Hemivertebra	16.64	10.71	7	64779	106	29509635
Mental status changes	16.63	10.71	32	64754	34895	29474846
Testicular cancer metastatic	16.50	10.71	6	64780	60	29509681
Acne	16.45	10.71	51	64735	9169	29500572
Cytomegalovirus syndrome	16.41	10.71	7	64779	110	29509631
Gastrointestinal obstruction	16.26	10.71	13	64773	691	29509050
Marrow hyperplasia	16.17	10.71	15	64771	976	29508765
Injection site pain	16.09	10.71	29	64757	32417	29477324
Dyspnoea exertional	16.05	10.71	35	64751	36455	29473286
Neutropenia	16.04	10.71	198	64588	131513	29378228
Haemorrhage intracranial	15.84	10.71	6	64780	14536	29495205
Proctocolectomy	15.75	10.71	6	64780	69	29509672
Gastric fistula	15.67	10.71	6	64780	70	29509671
Cryptococcal cutaneous infection	15.67	10.71	6	64780	70	29509671
Viral test positive	15.53	10.71	8	64778	196	29509545
Arrhythmia	15.52	10.71	28	64758	31285	29478456
Anorectal stenosis	15.51	10.71	4	64782	10	29509731
Cardiac myxoma	15.51	10.71	4	64782	10	29509731
Aplasia pure red cell	15.50	10.71	36	64750	5455	29504286
Peripheral T-cell lymphoma unspecified stage IV	15.43	10.71	5	64781	34	29509707
Urinary tract infection	15.42	10.71	94	64692	72260	29437481
Spermatozoa progressive motility decreased	15.40	10.71	7	64779	129	29509612
Aqueductal stenosis	15.38	10.71	3	64783	0	29509741
Uveal melanoma	15.38	10.71	3	64783	0	29509741
Dry mouth	15.37	10.71	15	64771	21769	29487972
Disseminated cytomegaloviral infection	15.34	10.71	8	64778	201	29509540
Proctitis	15.34	10.71	21	64765	2098	29507643
Aphthous ulcer	15.33	10.71	30	64756	4038	29505703
Tuberculosis gastrointestinal	15.31	10.71	8	64778	202	29509539
Skin cancer	15.25	10.71	47	64739	8421	29501320
Pneumoperitoneum	15.21	10.71	18	64768	1555	29508186
Ejection fraction decreased	15.20	10.71	8	64778	15970	29493771
Listeriosis	15.18	10.71	14	64772	904	29508837
Sideroblastic anaemia	15.03	10.71	8	64778	210	29509531
Anal stenosis	14.97	10.71	7	64779	138	29509603
Skin lesion	14.79	10.71	80	64706	18492	29491249
Sleep disorder	14.79	10.71	19	64767	24367	29485374
Infectious mononucleosis	14.68	10.71	11	64775	531	29509210
Intentional product misuse	14.63	10.71	34	64752	34627	29475114
Coloboma	14.61	10.71	7	64779	146	29509595
Urinary incontinence	14.61	10.71	9	64777	16472	29493269
Extrapyramidal disorder	14.53	10.71	3	64783	10828	29498913
Meconium peritonitis	14.52	10.71	4	64782	14	29509727
Herpes simplex colitis	14.52	10.71	4	64782	14	29509727
Respiratory tract infection fungal	14.51	10.71	12	64774	669	29509072
Anaplastic large cell lymphoma T- and null-cell types	14.50	10.71	6	64780	87	29509654
Memory impairment	14.43	10.71	37	64749	36433	29473308
Epstein-Barr viraemia	14.42	10.71	14	64772	964	29508777
Acute pulmonary histoplasmosis	14.40	10.71	7	64779	151	29509590
Hepatitis B	14.39	10.71	35	64751	5462	29504279
Metastases to lymph nodes	14.39	10.71	29	64757	3988	29505753
Optic neuritis	14.32	10.71	25	64761	3084	29506657
Ventricular tachycardia	14.31	10.71	17	64769	22557	29487184
Lymph node tuberculosis	14.28	10.71	10	64776	434	29509307
Pulmonary nocardiosis	14.24	10.71	11	64775	556	29509185
Therapy non-responder	14.18	10.71	116	64670	30795	29478946
Dementia	14.13	10.71	4	64782	11654	29498087
Mycobacterium kansasii infection	14.12	10.71	8	64778	238	29509503
Tender joint count increased	14.12	10.71	5	64781	46	29509695
Neoplasm progression	14.10	10.71	12	64774	18600	29491141
Haemophilus bacteraemia	14.10	10.71	4	64782	16	29509725
Pulmonary paracoccidioidomycosis	14.10	10.71	4	64782	16	29509725
Mycobacterium abscessus infection	14.08	10.71	10	64776	444	29509297
Functional gastrointestinal disorder	14.07	10.71	20	64766	2070	29507671
Rectal discharge	14.07	10.71	7	64779	159	29509582
Jejunal stenosis	14.02	10.71	5	64781	47	29509694
Small intestinal ulcer haemorrhage	14.02	10.71	5	64781	47	29509694
Drug tolerance decreased	14.01	10.71	16	64770	1330	29508411
Neonatal respiratory failure	14.00	10.71	9	64777	338	29509403
Prostatic specific antigen increased	14.00	10.71	5	64781	12559	29497182
Disseminated cryptococcosis	13.98	10.71	15	64771	1163	29508578
Nausea	13.95	10.71	506	64280	288749	29220992
Neoplasm skin	13.87	10.71	11	64775	578	29509163
Migraine	13.86	10.71	59	64727	12371	29497370
Vitamin B1 decreased	13.82	10.71	8	64778	248	29509493
Intentional self-injury	13.81	10.71	5	64781	12456	29497285
Thrombocytopenia	13.78	10.71	210	64576	134613	29375128
Pruritus	13.72	10.71	177	64609	116672	29393069
Skin papilloma	13.68	10.71	18	64768	1731	29508010
Hypervolaemia	13.68	10.71	11	64775	17534	29492207
Unevaluable event	13.65	10.71	28	64758	29823	29479918
Uveitis	13.62	10.71	36	64750	5911	29503830
Campylobacter gastroenteritis	13.56	10.71	12	64774	734	29509007
Necrotising herpetic retinopathy	13.55	10.71	4	64782	19	29509722
Enterovesical fistula	13.45	10.71	11	64775	604	29509137
Peritoneal candidiasis	13.38	10.71	4	64782	20	29509721
Hepatobiliary cancer	13.31	10.71	3	64783	3	29509738
Precursor T-lymphoblastic lymphoma/leukaemia stage I	13.31	10.71	3	64783	3	29509738
Hepatic angiosarcoma	13.31	10.71	3	64783	3	29509738
Leiomyoma	13.31	10.71	3	64783	3	29509738
Leiomyosarcoma metastatic	13.31	10.71	3	64783	3	29509738
Blood bilirubin decreased	13.29	10.71	8	64778	267	29509474
Aspiration	13.29	10.71	3	64783	10177	29499564
Olfactory nerve disorder	13.22	10.71	4	64782	21	29509720
Vomiting	13.20	10.71	359	64427	211901	29297840
Overgrowth bacterial	13.18	10.71	6	64780	111	29509630
Hyperhidrosis	13.16	10.71	85	64701	64455	29445286
Skin hyperpigmentation	13.16	10.71	23	64763	2841	29506900
Haematemesis	13.14	10.71	21	64765	24605	29485136
Pain	13.12	10.71	281	64505	171151	29338590
Hepatitis cholestatic	13.11	10.71	39	64747	6854	29502887
Pneumocystis jirovecii infection	13.07	10.71	16	64770	1432	29508309
Small intestine carcinoma	13.00	10.71	10	64776	502	29509239
Oropharyngeal pain	12.95	10.71	109	64677	29176	29480565
Brachycephaly	12.94	10.71	5	64781	60	29509681
Diffuse large B-cell lymphoma stage III	12.94	10.71	5	64781	60	29509681
Gastrointestinal scarring	12.94	10.71	6	64780	116	29509625
Pulmonary oedema	12.91	10.71	49	64737	42686	29467055
Oropharyngeal squamous cell carcinoma	12.87	10.71	7	64779	192	29509549
Cholangitis chronic	12.84	10.71	3	64783	4	29509737
Arthropathy	12.79	10.71	86	64700	21468	29488273
Epstein-Barr virus antibody positive	12.78	10.71	8	64778	287	29509454
Posterior reversible encephalopathy syndrome	12.76	10.71	46	64740	8930	29500811
Gastrointestinal oedema	12.76	10.71	15	64771	1286	29508455
Poor venous access	12.76	10.71	24	64762	3137	29506604
Small intestine adenocarcinoma	12.75	10.71	6	64780	120	29509621
Pseudolymphoma	12.75	10.71	10	64776	517	29509224
Human ehrlichiosis	12.74	10.71	7	64779	196	29509545
Myelitis transverse	12.73	10.71	13	64773	952	29508789
Skin laceration	12.72	10.71	53	64733	11009	29498732
Brain stem syndrome	12.70	10.71	9	64777	398	29509343
Rash maculo-papular	12.69	10.71	21	64765	24268	29485473
Fluid retention	12.66	10.71	20	64766	23540	29486201
Henoch-Schonlein purpura	12.62	10.71	15	64771	1301	29508440
Appendicectomy	12.61	10.71	12	64774	806	29508935
Altered state of consciousness	12.58	10.71	15	64771	19874	29489867
Cognitive disorder	12.58	10.71	20	64766	23479	29486262
Diaphragmatic injury	12.57	10.71	6	64780	124	29509617
Antiphospholipid syndrome	12.56	10.71	9	64777	405	29509336
Cytomegalovirus oesophagitis	12.52	10.71	9	64777	407	29509334
Oedema	12.50	10.71	46	64740	40437	29469304
Drug interaction	12.49	10.71	333	64453	197052	29312689
Accidental exposure to product	12.47	10.71	4	64782	10749	29498992
Diarrhoea	12.45	10.71	599	64187	332099	29177642
Microscopic polyangiitis	12.44	10.71	6	64780	127	29509614
Placental disorder	12.44	10.71	5	64781	67	29509674
Lymphocyte count	12.44	10.71	5	64781	67	29509674
Polydipsia	12.39	10.71	25	64761	3440	29506301
Colonic abscess	12.37	10.71	9	64777	415	29509326
Caesarean section	12.36	10.71	18	64768	1905	29507836
Leiomyosarcoma	12.27	10.71	6	64780	131	29509610
Toxic epidermal necrolysis	12.24	10.71	13	64773	18140	29491601
Short-bowel syndrome	12.18	10.71	7	64779	214	29509527
Vision blurred	12.18	10.71	46	64740	40130	29469611
Musculoskeletal discomfort	12.18	10.71	36	64750	6305	29503436
Lip swelling	12.12	10.71	6	64780	12404	29497337
Antibody test abnormal	12.11	10.71	6	64780	135	29509606
Anaplastic large cell lymphoma T- and null-cell types stage III	12.10	10.71	3	64783	6	29509735
Protein deficiency	12.10	10.71	3	64783	6	29509735
Actinic cheilitis	12.10	10.71	3	64783	6	29509735
Alternaria infection	12.02	10.71	8	64778	319	29509422
Gastrointestinal cancer metastatic	11.99	10.71	5	64781	74	29509667
Pneumonia legionella	11.87	10.71	16	64770	1575	29508166
Blood sodium decreased	11.84	10.71	9	64777	14758	29494983
Muscle rigidity	11.84	10.71	3	64783	9408	29500333
Eosinophilic myocarditis	11.80	10.71	9	64777	446	29509295
Alanine aminotransferase increased	11.79	10.71	99	64687	70845	29438896
Central nervous system lymphoma	11.76	10.71	11	64775	723	29509018
Death neonatal	11.76	10.71	8	64778	331	29509410
Focal segmental glomerulosclerosis	11.74	10.71	17	64769	1790	29507951
Haemodialysis	11.69	10.71	48	64738	9906	29499835
Neurological symptom	11.68	10.71	24	64762	3346	29506395
Chronic graft versus host disease in liver	11.63	10.71	8	64778	337	29509404
Scar	11.61	10.71	32	64754	5387	29504354
Adenocarcinoma	11.61	10.71	16	64770	1609	29508132
Vasculitis necrotising	11.54	10.71	10	64776	595	29509146
Hair follicle tumour benign	11.50	10.71	3	64783	8	29509733
Lymphadenopathy	11.48	10.71	94	64692	24955	29484786
Adverse drug reaction	11.44	10.71	22	64764	23998	29485743
Testis cancer	11.43	10.71	12	64774	908	29508833
Diabetic ketoacidosis	11.42	10.71	11	64775	16062	29493679
Gastrointestinal stoma output decreased	11.37	10.71	4	64782	36	29509705
Food intolerance	11.37	10.71	13	64773	1082	29508659
Peritoneal tuberculosis	11.30	10.71	8	64778	353	29509388
American trypanosomiasis	11.28	10.71	7	64779	247	29509494
Withdrawal syndrome	11.22	10.71	5	64781	10987	29498754
Underdose	11.21	10.71	6	64780	11863	29497878
Rhegmatogenous retinal detachment	11.18	10.71	4	64782	38	29509703
Opportunistic infection	11.15	10.71	15	64771	1474	29508267
Product administration error	11.12	10.71	9	64777	14301	29495440
Enterostomy	11.10	10.71	5	64781	90	29509651
Congenital arterial malformation	11.10	10.71	5	64781	90	29509651
Liver disorder	11.08	10.71	101	64685	27648	29482093
Complications of transplanted heart	11.08	10.71	7	64779	255	29509486
Sacroiliitis	11.07	10.71	13	64773	1114	29508627
Diaphragmatic hernia	11.06	10.71	7	64779	256	29509485
Acute respiratory failure	11.06	10.71	26	64760	26376	29483365
Anger	11.05	10.71	5	64781	10885	29498856
Dysarthria	11.00	10.71	33	64753	30878	29478863
Angina unstable	11.00	10.71	5	64781	10860	29498881
Perineal fistula	11	10.71	3	64783	10	29509731
Foetal cardiac disorder	11	10.71	3	64783	10	29509731
Mediastinum neoplasm	11	10.71	3	64783	10	29509731
Hodgkin's disease nodular sclerosis	11	10.71	3	64783	10	29509731
Ophthalmic herpes simplex	10.99	10.71	7	64779	259	29509482
Drug specific antibody	10.99	10.71	7	64779	259	29509482
Xanthoma	10.96	10.71	5	64781	93	29509648
Ageusia	10.95	10.71	3	64783	8935	29500806
Stenotrophomonas infection	10.93	10.71	16	64770	1701	29508040
Back pain	10.90	10.71	158	64628	102126	29407615
Anorectal disorder	10.87	10.71	12	64774	961	29508780
Rectal stenosis	10.86	10.71	6	64780	170	29509571
Restlessness	10.80	10.71	20	64766	22125	29487616
Immunosuppressant drug level decreased	10.78	10.71	13	64773	1145	29508596
Bile duct stenosis	10.76	10.71	13	64773	1147	29508594
Hepatitis chronic active	10.74	10.71	4	64782	43	29509698

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Off label use	931.34	9.77	3373	144871	629433	63721055
Drug ineffective	701.49	9.77	3780	144464	836467	63514021
Colitis ulcerative	541.05	9.77	438	147806	22590	64327898
Completed suicide	471.23	9.77	9	148235	224405	64126083
Post transplant lymphoproliferative disorder	395.13	9.77	256	147988	9288	64341200
Cytomegalovirus infection	371.70	9.77	443	147801	36756	64313732
Death	362.28	9.77	346	147898	482359	63868129
Exposure during pregnancy	358.91	9.77	642	147602	77033	64273455
Treatment failure	356.12	9.77	812	147432	116004	64234484
Intentional product use issue	312.06	9.77	682	147562	94682	64255806
Intestinal stenosis	309.09	9.77	150	148094	3064	64347424
Product use in unapproved indication	306.88	9.77	998	147246	175620	64174868
Fall	305.39	9.77	305	147939	416521	63933967
Condition aggravated	305.02	9.77	1671	146573	370755	63979733
Epstein-Barr virus infection	296.41	9.77	239	148005	12249	64338239
Product use issue	266.83	9.77	861	147383	150854	64199634
Hepatosplenic T-cell lymphoma	263.51	9.77	91	148153	731	64349757
Disease recurrence	244.64	9.77	331	147913	31179	64319309
Drug abuse	241.41	9.77	16	148228	132358	64218130
Diffuse large B-cell lymphoma	238.95	9.77	195	148049	10166	64340322
Toxicity to various agents	237.53	9.77	292	147952	363221	63987267
Cushingoid	232.04	9.77	169	148075	7434	64343054
Drug level below therapeutic	231.89	9.77	167	148077	7217	64343271
Fistula	221.52	9.77	182	148062	9579	64340909
Frequent bowel movements	216.63	9.77	238	148006	18067	64332421
Drug intolerance	216.60	9.77	931	147313	187061	64163427
Anal abscess	206.99	9.77	157	148087	7351	64343137
Haemophagocytic lymphohistiocytosis	206.74	9.77	228	148016	17381	64333107
Premature delivery	205.07	9.77	233	148011	18356	64332132
Anal fistula	203.05	9.77	135	148109	5118	64345370
Hypotension	192.12	9.77	365	147879	380609	63969879
Lymphoproliferative disorder	189.69	9.77	128	148116	4975	64345513
Maternal exposure during pregnancy	186.77	9.77	564	147680	95320	64255168
Nodular regenerative hyperplasia	184.47	9.77	71	148173	799	64349689
Ileal stenosis	184.45	9.77	92	148152	1998	64348490
Faecal calprotectin increased	181.79	9.77	110	148134	3530	64346958
Drug eruption	180.20	9.77	309	147935	35827	64314661
Inappropriate schedule of product administration	177.08	9.77	540	147704	91746	64258742
Transplant rejection	175.04	9.77	208	148036	17193	64333295
Disseminated tuberculosis	171.42	9.77	106	148138	3539	64346949
Febrile neutropenia	163.31	9.77	116	148128	187541	64162947
Kidney transplant rejection	162.74	9.77	151	148093	9360	64341128
Malignant neoplasm progression	162.74	9.77	31	148213	112840	64237648
SLE arthritis	162.19	9.77	57	148187	485	64350003
Epstein-Barr virus associated lymphoproliferative disorder	160.28	9.77	96	148148	3023	64347465
Confusional state	159.90	9.77	220	148024	260924	64089564
Squamous cell carcinoma	158.38	9.77	177	148067	13692	64336796
Hyponatraemia	154.14	9.77	74	148170	148265	64202223
Lupus-like syndrome	151.25	9.77	140	148104	8651	64341837
Somnolence	151.16	9.77	147	148097	203498	64146990
Blood pressure fluctuation	148.50	9.77	352	147892	51519	64298969
Atrial fibrillation	145.94	9.77	108	148136	170981	64179507
Progressive multifocal leukoencephalopathy	145.28	9.77	194	148050	18038	64332450
Therapeutic response decreased	143.86	9.77	349	147895	51839	64298649
Pancytopenia	142.71	9.77	680	147564	142629	64207859
Bone erosion	141.09	9.77	153	148091	11442	64339046
Pneumocystis jirovecii pneumonia	140.02	9.77	238	148006	27396	64323092
Basal cell carcinoma	139.91	9.77	253	147991	30585	64319903
Cytomegalovirus colitis	135.29	9.77	94	148150	3834	64346654
Overdose	134.45	9.77	102	148142	159464	64191024
Therapeutic product effect incomplete	132.80	9.77	530	147714	102952	64247536
Intestinal obstruction	131.89	9.77	271	147973	36015	64314473
Intestinal resection	131.19	9.77	84	148160	2984	64347504
Large intestinal stenosis	130.42	9.77	77	148167	2360	64348128
Therapeutic product effect decreased	130.21	9.77	568	147676	114783	64235705
Vasculitis	129.80	9.77	183	148061	17912	64332576
Cholestasis of pregnancy	129.32	9.77	56	148188	869	64349619
Cardiac failure congestive	128.41	9.77	70	148174	130510	64219978
Dizziness	123.99	9.77	538	147706	429625	63920863
Demyelination	121.79	9.77	111	148133	6723	64343765
B-cell lymphoma	120.17	9.77	100	148144	5357	64345131
Cardio-respiratory arrest	118.72	9.77	39	148205	98354	64252134
Haematochezia	117.72	9.77	378	147866	65995	64284493
Cytomegalovirus viraemia	116.52	9.77	134	148110	10694	64339794
Lung transplant rejection	115.68	9.77	58	148186	1274	64349214
Intentional overdose	115.13	9.77	32	148212	89912	64260576
Abscess	115.11	9.77	179	148065	19125	64331363
Syncope	113.26	9.77	117	148127	157518	64192970
Drug level decreased	113.22	9.77	136	148108	11367	64339121
Pulmonary tuberculosis	112.49	9.77	109	148135	7135	64343353
Elbow deformity	112.07	9.77	56	148188	1221	64349267
Acute kidney injury	110.21	9.77	595	147649	448645	63901843
Bradycardia	109.66	9.77	68	148176	118151	64232337
Abdominal pain	108.47	9.77	1146	147098	311229	64039259
Electrocardiogram QT prolonged	104.08	9.77	27	148217	79421	64271067
Hypokalaemia	103.87	9.77	77	148167	121826	64228662
Dyspnoea	102.37	9.77	1108	147136	717566	63632922
Leukopenia	101.91	9.77	482	147762	100760	64249728
Proteinuria	101.87	9.77	208	148036	27515	64322973
Cardiac arrest	101.22	9.77	123	148121	153941	64196547
Blood iron abnormal	99.04	9.77	50	148194	1115	64349373
Premature labour	98.81	9.77	104	148140	7516	64342972
Drug specific antibody present	98.34	9.77	87	148157	5067	64345421
Loss of consciousness	97.95	9.77	118	148126	148247	64202241
Colectomy	97.74	9.77	66	148178	2568	64347920
Clostridium difficile infection	97.69	9.77	240	148004	35923	64314565
Histoplasmosis disseminated	96.24	9.77	59	148185	1939	64348549
Rheumatoid arthritis	96.15	9.77	677	147567	163617	64186871
Tuberculosis	95.21	9.77	133	148111	12905	64337583
Red blood cell sedimentation rate increased	94.90	9.77	217	148027	31018	64319470
Clear cell renal cell carcinoma	94.01	9.77	60	148184	2119	64348369
Hypoglycaemia	93.11	9.77	45	148199	89847	64260641
Lupus nephritis	92.97	9.77	62	148182	2362	64348126
Diarrhoea haemorrhagic	91.81	9.77	121	148123	11106	64339382
Fatigue	91.76	9.77	1193	147051	747537	63602951
Erythema nodosum	91.57	9.77	75	148169	3929	64346559
Epstein-Barr virus test positive	91.24	9.77	45	148199	953	64349535
Product dose omission issue	90.79	9.77	195	148049	194552	64155936
Decreased appetite	88.98	9.77	339	147905	280950	64069538
Intestinal fistula	87.98	9.77	47	148197	1182	64349306
JC virus infection	87.75	9.77	68	148176	3287	64347201
Kaposi's sarcoma	87.55	9.77	40	148204	709	64349779
Myocardial infarction	86.84	9.77	155	148089	165666	64184822
Scleritis	86.15	9.77	64	148180	2902	64347586
Acute febrile neutrophilic dermatosis	86.04	9.77	67	148177	3262	64347226
Antinuclear antibody positive	85.89	9.77	88	148156	6162	64344326
Insomnia	85.81	9.77	206	148038	197630	64152858
Neutrophil count decreased	85.68	9.77	35	148209	77161	64273327
Arthritis	85.04	9.77	400	147844	83414	64267074
Squamous cell carcinoma of skin	85.02	9.77	120	148124	11756	64338732
Coma	84.62	9.77	48	148196	87567	64262921
Hepatic function abnormal	84.57	9.77	332	147912	63981	64286507
Histoplasmosis	83.10	9.77	54	148190	1968	64348520
C-reactive protein increased	82.85	9.77	434	147810	94475	64256013
Normal newborn	82.52	9.77	82	148162	5535	64344953
Asthenia	82.24	9.77	611	147633	427433	63923055
Sedation	81.95	9.77	3	148241	41459	64309029
Anal fissure	81.82	9.77	77	148167	4859	64345629
Cerebrovascular accident	81.05	9.77	119	148125	137464	64213024
Immunosuppression	80.53	9.77	111	148133	10635	64339853
Abortion spontaneous	80.09	9.77	178	148066	24965	64325523
Mycobacterial infection	79.11	9.77	61	148183	2927	64347561
Pre-eclampsia	78.94	9.77	84	148160	6147	64344341
Chronic allograft nephropathy	78.64	9.77	47	148197	1474	64349014
Arthralgia	77.58	9.77	1437	146807	440823	63909665
Dehydration	77.42	9.77	248	147996	216515	64133973
Nocardiosis	76.42	9.77	73	148171	4694	64345794
Granulomatosis with polyangiitis	76.00	9.77	52	148192	2068	64348420
Gastrointestinal inflammation	75.82	9.77	82	148162	6113	64344375
Renal cell carcinoma	75.06	9.77	81	148163	6023	64344465
Gastrointestinal lymphoma	74.41	9.77	23	148221	124	64350364
Respiratory arrest	73.34	9.77	16	148228	52969	64297519
T-cell lymphoma	72.55	9.77	41	148203	1155	64349333
Epidermodysplasia verruciformis	72.47	9.77	24	148220	167	64350321
Osteoporosis	72.20	9.77	237	148007	41843	64308645
Impaired gastric emptying	72.17	9.77	95	148149	8709	64341779
Contusion	71.70	9.77	94	148150	113871	64236617
Therapeutic response shortened	71.67	9.77	102	148142	10068	64340420
Weight decreased	70.97	9.77	984	147260	284755	64065733
Inflammation	70.95	9.77	318	147926	64982	64285506
Constipation	70.18	9.77	280	147964	229057	64121431
Coombs positive haemolytic anaemia	69.75	9.77	36	148208	842	64349646
Hair follicle tumour benign	69.66	9.77	29	148215	406	64350082
Blood glucose increased	69.06	9.77	74	148170	97999	64252489
Depressed level of consciousness	68.63	9.77	52	148192	81384	64269104
Human herpesvirus 8 infection	68.40	9.77	38	148206	1035	64349453
Colitis	67.75	9.77	291	147953	58383	64292105
Synovial fluid analysis	67.19	9.77	43	148201	1526	64348962
Hyperkalaemia	67.19	9.77	80	148164	101049	64249439
Heart transplant rejection	67.14	9.77	40	148204	1247	64349241
Gestational hypertension	66.90	9.77	44	148200	1637	64348851
Bone marrow failure	65.86	9.77	251	147993	47701	64302787
Lymphopenia	65.85	9.77	167	148077	25490	64324998
Diabetes mellitus	65.79	9.77	315	147929	66159	64284329
Pneumonia aspiration	65.57	9.77	27	148217	59244	64291244
Tenosynovitis stenosans	65.39	9.77	46	148198	1914	64348574
Orthostatic hypotension	64.92	9.77	14	148230	46724	64303764
Epstein-Barr virus associated lymphoma	64.89	9.77	35	148209	898	64349590
Chronic obstructive pulmonary disease	64.32	9.77	42	148202	71006	64279482
Cholangitis sclerosing	63.94	9.77	45	148199	1874	64348614
Platelet count decreased	63.33	9.77	187	148057	167524	64182964
Extrapulmonary tuberculosis	63.31	9.77	26	148218	351	64350137
Agitation	62.98	9.77	66	148178	88301	64262187
Inflammatory bowel disease	62.55	9.77	64	148180	4474	64346014
Hypogammaglobulinaemia	62.10	9.77	96	148148	10203	64340285
Hallucination	61.95	9.77	46	148198	72742	64277746
Aspergillus infection	61.49	9.77	124	148120	16255	64334233
Plasmablastic lymphoma	61.26	9.77	26	148218	383	64350105
Wrong technique in product usage process	60.75	9.77	37	148207	64937	64285551
Small intestinal stenosis	60.58	9.77	30	148214	641	64349847
Serotonin syndrome	60.56	9.77	9	148235	39273	64311215
Papilloma viral infection	59.93	9.77	39	148205	1425	64349063
Infusion related reaction	59.62	9.77	609	147635	163858	64186630
Varicella zoster virus infection	59.42	9.77	58	148186	3830	64346658
Immunosuppressant drug level decreased	59.17	9.77	42	148202	1773	64348715
Pain	59.10	9.77	906	147338	552605	63797883
Seizure	58.83	9.77	192	148052	166700	64183788
Balance disorder	58.34	9.77	64	148180	83862	64266626
Listeriosis	58.32	9.77	43	148201	1927	64348561
Crohn's disease	57.96	9.77	43	148201	1946	64348542
Rheumatoid nodule	57.64	9.77	104	148140	12547	64337941
Acute myocardial infarction	56.88	9.77	46	148198	69672	64280816
Drug tolerance decreased	56.57	9.77	75	148169	6923	64343565
Tremor	56.17	9.77	165	148079	148065	64202423
Anxiety	56.10	9.77	257	147987	202392	64148096
Lactic acidosis	56.00	9.77	36	148208	61374	64289114
Oedema peripheral	55.72	9.77	271	147973	210046	64140442
Neuropathy peripheral	55.31	9.77	117	148127	117408	64233080
Aphthous ulcer	54.90	9.77	103	148141	12803	64337685
Central nervous system lymphoma	54.52	9.77	41	148203	1894	64348594
Ankylosing spondylitis	54.26	9.77	80	148164	8154	64342334
Episcleritis	54.17	9.77	30	148214	812	64349676
Gastrointestinal haemorrhage	54.06	9.77	142	148102	132170	64218318
Lymphoma	52.88	9.77	106	148138	13835	64336653
Metabolic acidosis	52.85	9.77	51	148193	70907	64279581
Defaecation urgency	52.71	9.77	55	148189	3934	64346554
Unresponsive to stimuli	52.52	9.77	25	148219	50368	64300120
Hypersensitivity	52.21	9.77	685	147559	195767	64154721
International normalised ratio increased	52.19	9.77	63	148181	79104	64271384
Depression	51.60	9.77	231	148013	183060	64167428
Hepatic cirrhosis	51.44	9.77	155	148089	26143	64324345
Delirium	51.22	9.77	50	148194	69144	64281344
Cardiac failure	51.13	9.77	146	148098	132227	64218261
Palmar-plantar erythrodysaesthesia syndrome	51.02	9.77	4	148240	28815	64321673
Strongyloidiasis	50.83	9.77	48	148196	3042	64347446
Actinic keratosis	50.72	9.77	61	148183	5104	64345384
Hepatosplenomegaly	50.68	9.77	62	148182	5281	64345207
Injection site swelling	50.56	9.77	16	148228	41337	64309151
Lupus vasculitis	50.46	9.77	24	148220	468	64350020
Dyskinesia	50.42	9.77	14	148230	39374	64311114
Red blood cell sedimentation rate abnormal	50.32	9.77	114	148130	16192	64334296
Liver transplant rejection	50.12	9.77	47	148197	2952	64347536
Small intestinal obstruction	49.99	9.77	143	148101	23430	64327058
Immunosuppressant drug level increased	49.97	9.77	72	148172	7187	64343301
Autoimmune hepatitis	49.95	9.77	86	148158	9998	64340490
Back pain	49.45	9.77	354	147890	249817	64100671
Urinary retention	48.89	9.77	26	148218	49175	64301313
Peliosis hepatis	48.82	9.77	15	148229	79	64350409
Intentional self-injury	48.81	9.77	5	148239	29039	64321449
Heart rate irregular	48.47	9.77	156	148088	27257	64323231
Transplant dysfunction	48.34	9.77	68	148176	6640	64343848
Retinitis	47.56	9.77	39	148205	2046	64348442
White blood cell count decreased	47.44	9.77	194	148050	157643	64192845
Suicide attempt	47.34	9.77	56	148188	70951	64279537
Pneumonia cytomegaloviral	47.19	9.77	54	148190	4285	64346203
Accidental overdose	46.71	9.77	10	148234	33547	64316941
Mycobacterium abscessus infection	46.45	9.77	29	148215	985	64349503
Body temperature fluctuation	46.34	9.77	47	148197	3251	64347237
Enterocutaneous fistula	46.13	9.77	34	148210	1523	64348965
Intentional product misuse	46.11	9.77	59	148185	72236	64278252
Injection site erythema	45.97	9.77	57	148187	70743	64279745
Non-cirrhotic portal hypertension	45.87	9.77	21	148223	374	64350114
Subcutaneous abscess	45.72	9.77	68	148176	6985	64343503
Ulcer	45.44	9.77	136	148108	22854	64327634
Meningitis listeria	45.39	9.77	26	148218	752	64349736
Abscess intestinal	45.35	9.77	40	148204	2320	64348168
Nausea	45.08	9.77	1420	146824	784380	63566108
Pyoderma gangrenosum	44.85	9.77	45	148199	3073	64347415
Live birth	44.68	9.77	87	148157	11117	64339371
Abdominal adhesions	44.55	9.77	44	148200	2948	64347540
Rheumatoid factor negative	44.45	9.77	29	148215	1064	64349424
Disseminated cytomegaloviral infection	44.41	9.77	21	148223	404	64350084
Pleuritic pain	44.04	9.77	72	148172	8024	64342464
Fungal endocarditis	43.93	9.77	22	148222	482	64350006
Therapeutic reaction time decreased	43.78	9.77	36	148208	1896	64348592
Chorioretinopathy	43.75	9.77	38	148206	2159	64348329
Pulmonary mass	43.67	9.77	138	148106	23878	64326610
Varicella	43.66	9.77	41	148203	2580	64347908
Herpes simplex hepatitis	43.49	9.77	21	148223	424	64350064
Vomiting	43.43	9.77	951	147293	550166	63800322
Herpes zoster	43.21	9.77	321	147923	78866	64271622
Sopor	43.04	9.77	8	148236	29653	64320835
Abnormal behaviour	42.94	9.77	12	148232	33610	64316878
Candida infection	42.76	9.77	164	148080	31255	64319233
Drug level above therapeutic	42.55	9.77	65	148179	6836	64343652
Hyperhidrosis	42.45	9.77	146	148098	124774	64225714
Aggression	42.29	9.77	27	148217	46205	64304283
Joint dislocation	42.09	9.77	86	148158	11379	64339109
Joint swelling	41.97	9.77	712	147532	214670	64135818
Angiocentric lymphoma	41.88	9.77	25	148219	782	64349706
Intestinal perforation	41.74	9.77	102	148142	15211	64335277
Disorientation	41.72	9.77	40	148204	55788	64294700
Intestinal anastomosis	41.69	9.77	21	148223	466	64350022
Rectal abscess	41.69	9.77	32	148212	1525	64348963
Ileostomy	41.47	9.77	29	148215	1195	64349293
Premature rupture of membranes	41.41	9.77	47	148197	3697	64346791
Myopathy	41.19	9.77	111	148133	17569	64332919
Abdominal abscess	41.18	9.77	61	148183	6243	64344245
Epicondylitis	40.92	9.77	34	148210	1817	64348671
Suicidal ideation	40.71	9.77	56	148188	66486	64284002
Panniculitis	40.46	9.77	73	148171	8806	64341682
Rebound effect	40.21	9.77	53	148191	4864	64345624
Neoplasm progression	40.18	9.77	22	148222	40942	64309546
Cytomegalovirus enteritis	40.16	9.77	23	148221	665	64349823
Drug hypersensitivity	39.60	9.77	767	147477	237048	64113440
Cutaneous T-cell lymphoma	39.58	9.77	37	148207	2315	64348173
Caesarean section	39.55	9.77	83	148161	11191	64339297
Fistula discharge	39.37	9.77	26	148218	974	64349514
Plasma cell myeloma	39.36	9.77	29	148215	46046	64304442
Neuroendocrine carcinoma of the skin	39.18	9.77	26	148218	982	64349506
Complications of transplanted kidney	39.02	9.77	55	148189	5380	64345108
Aplasia pure red cell	39.00	9.77	63	148181	6951	64343537
Injection site pain	38.67	9.77	129	148115	111279	64239209
Medication error	38.28	9.77	35	148209	49931	64300557
Mucosal inflammation	37.95	9.77	53	148191	62531	64287957
Portal hypertension	37.54	9.77	58	148186	6161	64344327
Hypocalcaemia	37.35	9.77	25	148219	41728	64308760
Myasthenia gravis crisis	37.29	9.77	24	148220	860	64349628
Brain abscess	37.22	9.77	47	148197	4134	64346354
Gastrointestinal wall thickening	37.14	9.77	34	148210	2071	64348417
Meningitis cryptococcal	37.12	9.77	40	148204	2969	64347519
Contraindicated product administered	37.03	9.77	395	147849	107434	64243054
Myasthenia gravis	36.74	9.77	55	148189	5683	64344805
Lung abscess	36.47	9.77	43	148201	3523	64346965
Legionella infection	36.41	9.77	22	148222	704	64349784
Poisoning	36.17	9.77	4	148240	21875	64328613
Lymphadenitis	36.03	9.77	44	148200	3741	64346747
Mental status changes	35.90	9.77	53	148191	61109	64289379
C-reactive protein abnormal	35.81	9.77	147	148097	28900	64321588
Osteonecrosis	35.71	9.77	144	148100	28085	64322403
Ventricular tachycardia	35.70	9.77	17	148227	34248	64316240
Pneumocystis jirovecii infection	35.67	9.77	35	148209	2326	64348162
Pancreatitis	35.62	9.77	247	147997	59360	64291128
Drug ineffective for unapproved indication	35.62	9.77	154	148090	30979	64319509
Visceral leishmaniasis	35.33	9.77	24	148220	943	64349545
Pulmonary fibrosis	35.11	9.77	149	148095	29729	64320759
Rhegmatogenous retinal detachment	34.96	9.77	13	148231	132	64350356
Mycobacterium avium complex infection	34.62	9.77	44	148200	3896	64346592
Synovitis	34.50	9.77	364	147880	98726	64251762
Glossodynia	34.27	9.77	60	148184	64636	64285852
Restlessness	34.04	9.77	25	148219	39760	64310728
Anaphylactic reaction	33.93	9.77	272	147972	68392	64282096
Malignant melanoma	33.91	9.77	85	148159	12879	64337609
Coronary artery disease	33.91	9.77	54	148190	60379	64290109
Obliterative bronchiolitis	33.89	9.77	36	148208	2629	64347859
Fluid retention	33.69	9.77	53	148191	59553	64290935
Dysgeusia	33.67	9.77	35	148209	47012	64303476
Injection site bruising	33.60	9.77	21	148223	36352	64314136
Overlap syndrome	33.59	9.77	21	148223	715	64349773
Eosinophilic granulomatosis with polyangiitis	33.28	9.77	37	148207	2845	64347643
Bronchopulmonary aspergillosis	33.19	9.77	108	148136	18977	64331511
Full blood count decreased	32.96	9.77	6	148238	22576	64327912
Angina pectoris	32.87	9.77	33	148211	45048	64305440
Hyperglycaemia	32.79	9.77	56	148188	60912	64289576
Cytomegalovirus chorioretinitis	32.77	9.77	48	148196	4864	64345624
Muscle injury	32.73	9.77	10	148234	26427	64324061
Anti-neutrophil cytoplasmic antibody positive vasculitis	32.71	9.77	37	148207	2899	64347589
Feeling abnormal	32.61	9.77	177	148067	133425	64217063
Infectious mononucleosis	32.56	9.77	29	148215	1704	64348784
Pulmonary oedema	32.45	9.77	84	148160	78590	64271898
Phospholipidosis	32.44	9.77	12	148232	120	64350368
Infection reactivation	32.37	9.77	31	148213	1999	64348489
Female genital tract fistula	32.21	9.77	35	148209	2623	64347865
Cardiac disorder	32.15	9.77	49	148195	55767	64294721
Neutropenia	32.11	9.77	374	147870	239250	64111238
Skin lesion	31.93	9.77	167	148077	36315	64314173
Anorectal stenosis	31.91	9.77	9	148235	33	64350455
Cutaneous leishmaniasis	31.89	9.77	15	148229	285	64350203
Therapeutic product effect variable	31.86	9.77	28	148216	1616	64348872
Pregnancy	31.82	9.77	113	148131	20752	64329736
Natural killer-cell leukaemia	31.36	9.77	11	148233	93	64350395
Hypomagnesaemia	31.31	9.77	24	148220	37352	64313136
Anal cancer	31.22	9.77	19	148225	616	64349872
Bone pain	31.20	9.77	38	148206	47534	64302954
Gastrointestinal fistula	31.17	9.77	19	148225	618	64349870
Cytomegalovirus test positive	31.08	9.77	48	148196	5096	64345392
Vision blurred	31.05	9.77	105	148139	90211	64260277
Cytomegalovirus infection reactivation	31.05	9.77	51	148193	5705	64344783
Blood calcium decreased	31.04	9.77	10	148234	25544	64324944
Impaired work ability	31.00	9.77	91	148153	15128	64335360
Exostosis	30.98	9.77	76	148168	11362	64339126
Accidental exposure to product	30.83	9.77	11	148233	26353	64324135
Injury	30.51	9.77	51	148193	55941	64294547
Squamous cell carcinoma of the tongue	30.44	9.77	19	148225	645	64349843
Osteonecrosis of jaw	30.38	9.77	28	148216	39797	64310691
Transient ischaemic attack	30.36	9.77	34	148210	44148	64306340
Hypervolaemia	30.31	9.77	26	148218	38259	64312229
Mycoplasma infection	30.28	9.77	19	148225	651	64349837
Complications of transplanted lung	30.18	9.77	16	148228	396	64350092
Cognitive disorder	30.18	9.77	50	148194	55037	64295451
Lymphadenopathy	30.02	9.77	197	148047	46489	64303999
Musculoskeletal stiffness	29.99	9.77	423	147821	122783	64227705
Foetal death	29.93	9.77	51	148193	5879	64344609
Crepitations	29.80	9.77	60	148184	7855	64342633
Muscle fatigue	29.77	9.77	36	148208	3029	64347459
Myelosuppression	29.69	9.77	121	148123	23709	64326779
Proctalgia	29.30	9.77	58	148186	7501	64342987
Listeria sepsis	29.05	9.77	18	148226	603	64349885
Pouchitis	29.04	9.77	20	148224	804	64349684
Irritability	29.04	9.77	25	148219	36721	64313767
Poor venous access	28.97	9.77	78	148166	12339	64338149
Rectal cancer metastatic	28.89	9.77	16	148228	433	64350055
Antiphospholipid syndrome	28.79	9.77	26	148218	1556	64348932
Lupus myocarditis	28.78	9.77	10	148234	82	64350406
Anaemia	28.75	9.77	657	147587	378023	63972465
Complications of bone marrow transplant	28.68	9.77	18	148226	617	64349871
Phaeohyphomycosis	28.59	9.77	22	148222	1052	64349436
Thrombocytopenia	28.57	9.77	353	147891	223448	64127040
Injection site inflammation	28.34	9.77	36	148208	3185	64347303
Autoimmune haemolytic anaemia	28.28	9.77	55	148189	7021	64343467
Non-Hodgkin's lymphoma	28.25	9.77	25	148219	1456	64349032
Cow pox	28.23	9.77	8	148236	30	64350458
Neoplasm malignant	28.15	9.77	122	148122	24566	64325922
Splenomegaly	28.02	9.77	98	148146	17863	64332625
Rectal fissure	27.98	9.77	19	148225	746	64349742
Multiple sclerosis relapse	27.89	9.77	32	148212	41103	64309385
Renal mass	27.89	9.77	33	148211	2714	64347774
Joint stiffness	27.88	9.77	141	148103	30263	64320225
Nicotinic acid deficiency	27.87	9.77	11	148233	133	64350355
Thiopurine methyltransferase decreased	27.86	9.77	14	148230	309	64350179
Disturbance in attention	27.80	9.77	32	148212	41042	64309446
Sinus bradycardia	27.73	9.77	9	148235	22884	64327604
Nephropathy toxic	27.70	9.77	96	148148	17418	64333070
Ganglioneuroma	27.37	9.77	11	148233	140	64350348
Skin ulcer	27.33	9.77	184	148060	43790	64306698
Polyomavirus-associated nephropathy	27.31	9.77	44	148200	4844	64345644
Melaena	27.16	9.77	51	148193	53497	64296991
Epstein Barr virus positive mucocutaneous ulcer	27.15	9.77	18	148226	679	64349809
Intestinal anastomosis complication	27.12	9.77	13	148231	258	64350230
Tuberculosis of central nervous system	27.08	9.77	15	148229	406	64350082
Opportunistic infection	27.06	9.77	32	148212	2630	64347858
Hepatitis cholestatic	27.01	9.77	75	148169	12080	64338408
Duodenal ulcer perforation	26.82	9.77	24	148220	34601	64315887
Foetal growth restriction	26.80	9.77	26	148218	1704	64348784
Inappropriate antidiuretic hormone secretion	26.58	9.77	9	148235	22280	64328208
Bronchiectasis	26.40	9.77	82	148162	14058	64336430
Intestinal mass	26.24	9.77	21	148223	1064	64349424
Device dislocation	26.24	9.77	8	148236	21170	64329318
Anaplastic large cell lymphoma T- and null-cell types	26.10	9.77	10	148234	111	64350377
Renal transplant failure	26.07	9.77	25	148219	1615	64348873
Sepsis neonatal	26.06	9.77	8	148236	42	64350446
Sleep disorder	25.99	9.77	62	148182	59647	64290841
Rectal haemorrhage	25.87	9.77	236	148008	61581	64288907
Granuloma	25.79	9.77	51	148193	6590	64343898
Serum sickness	25.50	9.77	34	148210	3155	64347333
Pulmonary vasculitis	25.46	9.77	12	148232	229	64350259
Pelvic abscess	25.39	9.77	26	148218	1819	64348669
Haematoma	25.31	9.77	42	148202	46208	64304280
Therapy non-responder	25.29	9.77	247	147997	65652	64284836
Blister	25.28	9.77	98	148146	80869	64269619
Diabetic ketoacidosis	25.21	9.77	19	148225	29826	64320662
Primary biliary cholangitis	25.20	9.77	20	148224	1001	64349487
Lung infiltration	25.19	9.77	105	148139	20784	64329704
Large intestinal ulcer	25.16	9.77	39	148205	4154	64346334
Underdose	25.15	9.77	14	148230	25815	64324673
Product quality issue	25.14	9.77	19	148225	29780	64320708
Meningoencephalitis viral	25.08	9.77	14	148230	385	64350103
Abdominal discomfort	25.02	9.77	283	147961	182039	64168449
Scleroderma renal crisis	24.98	9.77	14	148230	388	64350100
Pseudopolyp	24.95	9.77	14	148230	389	64350099
Uveitis	24.94	9.77	75	148169	12633	64337855
Dysarthria	24.83	9.77	63	148181	59343	64291145
Diffuse large B-cell lymphoma stage IV	24.82	9.77	15	148229	480	64350008
Subdural haematoma	24.82	9.77	17	148227	28037	64322451
Muscle rigidity	24.75	9.77	5	148239	17468	64333020
Swelling	24.71	9.77	242	148002	159976	64190512
Rash maculo-papular	24.56	9.77	44	148200	46982	64303506
American trypanosomiasis	24.55	9.77	13	148231	321	64350167
Anal stenosis	24.51	9.77	13	148231	322	64350166
Emotional distress	24.47	9.77	28	148216	36010	64314478
Steroid dependence	24.44	9.77	14	148230	405	64350083
Trichodysplasia spinulosa	24.34	9.77	17	148227	699	64349789
Salmonellosis	24.28	9.77	22	148222	1322	64349166
Leiomyosarcoma metastatic	24.24	9.77	6	148238	11	64350477
Memory impairment	24.08	9.77	108	148136	85574	64264914
Foot deformity	24.00	9.77	88	148156	16416	64334072
Withdrawal syndrome	23.95	9.77	12	148232	23480	64327008
Synovial cyst	23.91	9.77	54	148190	7653	64342835
Bronchitis	23.90	9.77	149	148095	108594	64241894
Pneumatosis intestinalis	23.84	9.77	43	148201	5186	64345302
Delusion	23.82	9.77	6	148238	18008	64332480
Acquired gene mutation	23.80	9.77	26	148218	1960	64348528
Dementia	23.72	9.77	9	148235	20757	64329731
Periumbilical abscess	23.64	9.77	8	148236	60	64350428
Myasthenic syndrome	23.55	9.77	16	148228	629	64349859
Proctocolectomy	23.48	9.77	9	148235	100	64350388
Enteritis	23.45	9.77	71	148173	12006	64338482
Rectal discharge	23.42	9.77	15	148229	533	64349955
Growth retardation	23.32	9.77	23	148221	1538	64348950
Mucous stools	23.32	9.77	33	148211	3240	64347248
Abscess rupture	23.20	9.77	12	148232	282	64350206
Enterostomy	23.20	9.77	11	148233	213	64350275
Altered state of consciousness	23.08	9.77	32	148212	37870	64312618
Antineutrophil cytoplasmic antibody increased	22.94	9.77	9	148235	107	64350381
Tonsillar hypertrophy	22.92	9.77	21	148223	1280	64349208
Hypersensitivity vasculitis	22.82	9.77	49	148195	6712	64343776
Cholesteatoma	22.79	9.77	9	148235	109	64350379
Drug tolerance	22.76	9.77	46	148198	6039	64344449
Proctitis	22.73	9.77	32	148212	3127	64347361
Graft versus host disease in lung	22.57	9.77	17	148227	787	64349701
Somatic delusion	22.57	9.77	16	148228	674	64349814
Dermatomyositis	22.57	9.77	30	148214	2776	64347712
Chronic myeloid leukaemia	22.55	9.77	33	148211	3341	64347147
Mydriasis	22.50	9.77	4	148240	15308	64335180
Eye infection toxoplasmal	22.49	9.77	14	148230	473	64350015
Neoplasm skin	22.43	9.77	20	148224	1177	64349311
Jejunal stenosis	22.37	9.77	8	148236	72	64350416
Drug level abnormal	22.32	9.77	10	148234	169	64350319
Rheumatoid lung	22.28	9.77	28	148216	2451	64348037
Asthma	22.23	9.77	128	148116	95097	64255391
Blood sodium decreased	22.17	9.77	21	148223	29461	64321027
Ejection fraction decreased	22.12	9.77	20	148224	28687	64321801
Glomerulosclerosis	21.91	9.77	18	148226	947	64349541
Pulmonary granuloma	21.91	9.77	24	148220	1815	64348673
Helicobacter infection	21.78	9.77	34	148210	38328	64312160
Pruritus	21.77	9.77	549	147695	311851	64038637
Anaplastic large-cell lymphoma	21.75	9.77	10	148234	180	64350308
Tenderness	21.69	9.77	96	148148	19506	64330982
Gastrointestinal mucosa hyperaemia	21.66	9.77	13	148231	411	64350077
Cytomegalovirus duodenitis	21.62	9.77	8	148236	80	64350408
Stiff person syndrome	21.56	9.77	11	148233	251	64350237
Arrhythmia	21.47	9.77	57	148187	52887	64297601
Jaw fracture	21.31	9.77	29	148215	2745	64347743
Therapy cessation	21.25	9.77	26	148218	32463	64318025
Pulmonary nocardiosis	21.20	9.77	16	148228	743	64349745
Intestinal mucosal hypertrophy	21.13	9.77	11	148233	262	64350226
Dysplasia	21.06	9.77	19	148225	1135	64349353
Device issue	21.02	9.77	13	148231	22635	64327853
Pulmonary embolism	20.94	9.77	225	148019	146131	64204357
Anorectal disorder	20.87	9.77	24	148220	1915	64348573
Hepatitis viral	20.80	9.77	17	148227	888	64349600
Chorioretinitis	20.75	9.77	15	148229	652	64349836
Head injury	20.73	9.77	27	148217	32815	64317673
Dyspnoea exertional	20.68	9.77	93	148151	73637	64276851
Gait disturbance	20.68	9.77	275	147969	171880	64178608
B-cell unclassifiable lymphoma high grade	20.63	9.77	5	148239	8	64350480
Wrist deformity	20.60	9.77	23	148221	1777	64348711
Tachycardia	20.59	9.77	232	148012	149347	64201141
Injection site mass	20.55	9.77	7	148237	17263	64333225
Rhabdomyolysis	20.51	9.77	125	148119	91601	64258887
Drug withdrawal syndrome	20.51	9.77	25	148219	31266	64319222
Microscopic polyangiitis	20.47	9.77	11	148233	280	64350208
Abnormal faeces	20.39	9.77	43	148201	5816	64344672
Blood cholesterol increased	20.37	9.77	190	148054	49876	64300612
Small intestine carcinoma	20.32	9.77	16	148228	792	64349696
Rectal stenosis	20.30	9.77	11	148233	285	64350203
Anogenital warts	20.25	9.77	16	148228	796	64349692
Cytomegalovirus syndrome	20.23	9.77	11	148233	287	64350201
Colectomy total	20.22	9.77	10	148234	213	64350275
Upper gastrointestinal haemorrhage	20.20	9.77	31	148213	35189	64315299
Enterovesical fistula	20.12	9.77	17	148227	930	64349558
Hypothyroidism	20.11	9.77	39	148205	40418	64310070
Liver function test increased	20.10	9.77	131	148113	30839	64319649
Wound	19.96	9.77	99	148145	76378	64274110
Nodule	19.93	9.77	88	148156	17859	64332629
Tonsil cancer	19.92	9.77	17	148227	943	64349545
Extrapyramidal disorder	19.92	9.77	10	148234	19542	64330946
Systemic lupus erythematosus	19.91	9.77	269	147975	77343	64273145
Pollakiuria	19.82	9.77	26	148218	31504	64318984
Hodgkin's disease	19.75	9.77	16	148228	825	64349663
Cytomegalovirus hepatitis	19.68	9.77	14	148230	593	64349895
Disseminated cryptococcosis	19.63	9.77	21	148223	1546	64348942
Urinary incontinence	19.63	9.77	33	148211	36118	64314370
Cervical dysplasia	19.62	9.77	23	148221	1873	64348615
Peritoneal tuberculosis	19.55	9.77	13	148231	493	64349995
Drug resistance	19.54	9.77	143	148101	34959	64315529
Chronic hepatitis	19.54	9.77	19	148225	1249	64349239
Gestational diabetes	19.43	9.77	41	148203	5549	64344939
Food intolerance	19.41	9.77	28	148216	2798	64347690
Chronic gastrointestinal bleeding	19.39	9.77	12	148232	401	64350087
Porokeratosis	19.37	9.77	10	148234	234	64350254
Granuloma skin	19.34	9.77	43	148201	6031	64344457
Autoimmune neutropenia	19.26	9.77	12	148232	406	64350082
Premature separation of placenta	19.26	9.77	18	148226	1126	64349362
Intestinal fibrosis	19.22	9.77	8	148236	112	64350376
Graft loss	19.21	9.77	17	148227	990	64349498
Peripheral T-cell lymphoma unspecified stage IV	19.16	9.77	6	148238	34	64350454
Pancreatitis acute	19.16	9.77	166	148078	42689	64307799
Carcinoid tumour pulmonary	19.08	9.77	11	148233	322	64350166
Trichostasis spinulosa	19.01	9.77	5	148239	13	64350475
Hyperthyroidism	18.97	9.77	9	148235	18170	64332318
Palatal ulcer	18.96	9.77	8	148236	116	64350372
Electrolyte imbalance	18.96	9.77	18	148226	25225	64325263
Hypophagia	18.96	9.77	39	148205	39548	64310940
Epstein-Barr viraemia	18.93	9.77	22	148222	1775	64348713
Necrotising herpetic retinopathy	18.90	9.77	8	148236	117	64350371
Joint effusion	18.89	9.77	71	148173	13402	64337086
Splenic embolism	18.76	9.77	9	148235	179	64350309
Myoclonus	18.76	9.77	18	148226	25100	64325388
Polyhydramnios	18.75	9.77	20	148224	1467	64349021
Dyspepsia	18.72	9.77	108	148136	80204	64270284
Creatinine renal clearance decreased	18.69	9.77	5	148239	14416	64336072
Urticaria	18.69	9.77	457	147787	146860	64203628
Femur fracture	18.68	9.77	31	148213	34104	64316384
Brain stem syndrome	18.66	9.77	15	148229	765	64349723
Leiomyosarcoma	18.56	9.77	10	148234	256	64350232
Angioedema	18.55	9.77	76	148168	61745	64288743
Intestinal ulcer	18.52	9.77	21	148223	1650	64348838
Paracoccidioides infection	18.49	9.77	7	148237	75	64350413
Cryptococcosis	18.49	9.77	27	148217	2728	64347760
Hip fracture	18.46	9.77	21	148223	27078	64323410
Necrotising retinitis	18.42	9.77	17	148227	1046	64349442
Henoch-Schonlein purpura	18.38	9.77	24	148220	2182	64348306
Paraesthesia	18.37	9.77	209	148035	134313	64216175
Bacillary angiomatosis	18.36	9.77	9	148235	188	64350300
Pyrexia	18.34	9.77	1506	146738	557138	63793350
Vasculitis necrotising	18.30	9.77	17	148227	1055	64349433
Eye ulcer	18.21	9.77	10	148234	266	64350222
Transient hypogammaglobulinaemia of infancy	18.21	9.77	6	148238	41	64350447
Product administration error	18.21	9.77	22	148222	27621	64322867
Hospitalisation	18.15	9.77	100	148144	75107	64275381
Oesophageal squamous cell carcinoma	18.00	9.77	12	148232	457	64350031
Oral pain	17.98	9.77	22	148222	27471	64323017
Lymph node tuberculosis	17.96	9.77	16	148228	940	64349548
Mouth ulceration	17.96	9.77	132	148112	32312	64318176
Blood glucose decreased	17.94	9.77	16	148228	23107	64327381
Blood parathyroid hormone decreased	17.92	9.77	47	148197	7319	64343169
HELLP syndrome	17.92	9.77	14	148230	685	64349803
Lymphocytic infiltration	17.91	9.77	19	148225	1385	64349103
Dry skin	17.91	9.77	59	148185	51102	64299386
Disease progression	17.87	9.77	224	148020	141456	64209032
Tractional retinal detachment	17.86	9.77	7	148237	83	64350405
Weber tuning fork test abnormal	17.78	9.77	7	148237	84	64350404
Irritable bowel syndrome	17.74	9.77	37	148207	37332	64313156
Cystitis escherichia	17.72	9.77	12	148232	469	64350019
Faecal calprotectin abnormal	17.71	9.77	8	148236	138	64350350
Flank pain	17.69	9.77	79	148165	16110	64334378
Gastrointestinal obstruction	17.68	9.77	19	148225	1406	64349082
Antisynthetase syndrome	17.65	9.77	8	148236	139	64350349
Burkitt's lymphoma stage III	17.59	9.77	5	148239	19	64350469
Hepatitis	17.56	9.77	171	148073	45411	64305077
Pseudoxanthoma elasticum-like syndrome	17.55	9.77	4	148240	4	64350484
Depressed mood	17.52	9.77	43	148201	40969	64309519
Infective pulmonary exacerbation of cystic fibrosis	17.51	9.77	3	148241	11793	64338695
Gastrointestinal stoma output abnormal	17.50	9.77	6	148238	47	64350441
Neuromyelitis optica spectrum disorder	17.42	9.77	15	148229	842	64349646
Amnesia	17.36	9.77	55	148189	48214	64302274
Dermatitis psoriasiform	17.35	9.77	23	148221	2123	64348365
Retinal scar	17.32	9.77	11	148233	385	64350103
Ileal ulcer	17.24	9.77	16	148228	992	64349496
Viral test positive	17.22	9.77	11	148233	389	64350099
Laparotomy	17.22	9.77	10	148234	297	64350191
Gastrooesophageal reflux disease	17.21	9.77	116	148128	83027	64267461
Appendicectomy	17.20	9.77	23	148221	2140	64348348
Anastomotic complication	17.20	9.77	11	148233	390	64350098
Acne conglobata	17.19	9.77	5	148239	21	64350467
Lung neoplasm	17.19	9.77	42	148202	6263	64344225
Epistaxis	17.16	9.77	319	147925	97812	64252676
Muscle spasms	17.15	9.77	435	147809	140588	64209900
Focal segmental glomerulosclerosis	17.13	9.77	27	148217	2917	64347571
Conjunctivitis	17.01	9.77	92	148152	20262	64330226
Optic neuritis	16.98	9.77	49	148195	8067	64342421
Nightmare	16.93	9.77	14	148230	20979	64329509
Infertility	16.83	9.77	12	148232	510	64349978
Respiratory gas exchange disorder	16.81	9.77	14	148230	751	64349737
Aspergillosis oral	16.78	9.77	6	148238	54	64350434
Laryngeal disorder	16.76	9.77	15	148229	887	64349601
Gastrointestinal stoma complication	16.69	9.77	23	148221	2203	64348285
Cytokine release syndrome	16.66	9.77	14	148230	20815	64329673
Hodgkin's disease nodular sclerosis	16.66	9.77	5	148239	24	64350464
Headache	16.65	9.77	1022	147222	528445	63822043
Therapy interrupted	16.61	9.77	13	148231	20023	64330465
Encephalopathy	16.61	9.77	74	148170	58745	64291743
Haematemesis	16.59	9.77	54	148190	46945	64303543
Testicular cancer metastatic	16.58	9.77	6	148238	56	64350432
Malignant polyp	16.54	9.77	8	148236	162	64350326
Fistula of small intestine	16.53	9.77	13	148231	642	64349846
Haemophilus infection	16.48	9.77	21	148223	1864	64348624
Hypergammaglobulinaemia	16.46	9.77	13	148231	646	64349842
Pneumonia legionella	16.46	9.77	24	148220	2422	64348066
Hepatic enzyme increased	16.45	9.77	403	147841	129540	64220948
Pseudomonas infection	16.44	9.77	83	148161	17800	64332688
Ileectomy	16.41	9.77	8	148236	165	64350323
Febrile bone marrow aplasia	16.41	9.77	3	148241	11252	64339236
Chest discomfort	16.40	9.77	179	148065	115927	64234561
Intestinal dilatation	16.39	9.77	23	148221	2241	64348247
Marrow hyperplasia	16.38	9.77	18	148226	1366	64349122
Mycetoma mycotic	16.38	9.77	7	148237	105	64350383
Ventricular extrasystoles	16.36	9.77	10	148234	17519	64332969
Cardiogenic shock	16.34	9.77	31	148213	32396	64318092
Mucocutaneous leishmaniasis	16.31	9.77	11	148233	427	64350061
Muscle spasticity	16.28	9.77	9	148235	16660	64333828
Renal impairment	16.28	9.77	416	147828	134601	64215887
Ischaemic stroke	16.23	9.77	26	148218	29009	64321479
Narcotic bowel syndrome	16.20	9.77	9	148235	245	64350243
Stevens-Johnson syndrome	16.18	9.77	34	148210	34215	64316273
Neutrophilic dermatosis	16.17	9.77	12	148232	543	64349945
Discomfort	16.17	9.77	114	148130	80764	64269724
Systemic candida	16.16	9.77	37	148207	5292	64345196
Herpes zoster meningoencephalitis	15.94	9.77	13	148231	677	64349811
Skin cancer	15.88	9.77	62	148182	11912	64338576
Sebaceous carcinoma	15.80	9.77	7	148237	115	64350373
Corynebacterium infection	15.79	9.77	15	148229	958	64349530
Ventricular fibrillation	15.71	9.77	19	148225	23841	64326647
Skin papilloma	15.64	9.77	36	148208	5167	64345321
Fear	15.60	9.77	14	148230	20157	64330331
Exercise tolerance increased	15.59	9.77	5	148239	31	64350457
Stress at work	15.58	9.77	15	148229	974	64349514
Anal skin tags	15.55	9.77	10	148234	358	64350130
Troponin increased	15.50	9.77	8	148236	15391	64335097
Cardiac valve vegetation	15.48	9.77	14	148230	839	64349649
Hepatitis B	15.48	9.77	46	148198	7699	64342789
DNA antibody	15.46	9.77	5	148239	32	64350456
Eosinophilic bronchitis	15.37	9.77	10	148234	365	64350123
Hallucination, auditory	15.34	9.77	10	148234	16929	64333559
Bowel movement irregularity	15.34	9.77	34	148210	4759	64345729
Blood bilirubin increased	15.31	9.77	74	148170	57479	64293009
Anaphylactic shock	15.28	9.77	29	148215	30299	64320189
Blood potassium decreased	15.27	9.77	45	148199	40354	64310134
Laryngeal mass	15.24	9.77	6	148238	72	64350416
Herpes simplex test positive	15.23	9.77	10	148234	371	64350117
Sleep disorder due to general medical condition, insomnia type	15.19	9.77	23	148221	26247	64324241
Herpes simplex	15.17	9.77	56	148188	10480	64340008
Epstein-Barr virus antibody positive	15.15	9.77	12	148232	599	64349889
Acinetobacter infection	15.15	9.77	23	148221	2406	64348082
Human ehrlichiosis	15.13	9.77	10	148234	375	64350113
Injection site pruritus	15.13	9.77	41	148203	37785	64312703
Mycobacterium kansasii infection	15.12	9.77	9	148235	280	64350208
Mucormycosis	15.05	9.77	44	148200	7297	64343191
Pyometra	15.02	9.77	6	148238	75	64350413
Heart rate decreased	15.01	9.77	193	148051	54874	64295614
Anaemia macrocytic	14.99	9.77	32	148212	4366	64346122
Folliculitis	14.94	9.77	29	148215	30048	64320440
Hypoxia	14.94	9.77	130	148114	88019	64262469
Retinal injury	14.89	9.77	9	148235	288	64350200
Ileal perforation	14.89	9.77	14	148230	882	64349606
Product storage error	14.84	9.77	6	148238	13312	64337176
Tinea capitis	14.79	9.77	4	148240	12	64350476
Placental necrosis	14.79	9.77	4	148240	12	64350476
Torsade de pointes	14.74	9.77	11	148233	17352	64333136
Obstructive airways disorder	14.70	9.77	19	148225	23166	64327322
Haematocrit decreased	14.70	9.77	70	148174	54585	64295903
Anger	14.66	9.77	9	148235	15732	64334756
Drug specific antibody absent	14.60	9.77	7	148237	139	64350349
Hallucination, visual	14.57	9.77	26	148218	27808	64322680
Listeria encephalitis	14.57	9.77	9	148235	300	64350188
Mitochondrial neurogastrointestinal encephalopathy	14.55	9.77	4	148240	13	64350475
Glomerulonephritis	14.54	9.77	25	148219	2903	64347585
Pneumonia cryptococcal	14.47	9.77	16	148228	1223	64349265
Hidradenitis	14.45	9.77	22	148222	2307	64348181
Oxygen saturation decreased	14.44	9.77	167	148077	107009	64243479
Meningitis aseptic	14.39	9.77	37	148207	5693	64344795
Gastrointestinal oedema	14.37	9.77	22	148222	2318	64348170
Complications of transplanted heart	14.35	9.77	9	148235	308	64350180
Proctectomy	14.35	9.77	6	148238	85	64350403
Atrial flutter	14.34	9.77	14	148230	19366	64331122
Joint tuberculosis	14.33	9.77	7	148237	145	64350343
Respiratory tract infection fungal	14.33	9.77	15	148229	1077	64349411
Hand deformity	14.32	9.77	85	148159	62686	64287802
Pharyngeal oedema	14.30	9.77	9	148235	15522	64334966
Chest pain	14.27	9.77	423	147821	235557	64114931
Night sweats	14.27	9.77	136	148108	35910	64314578
Salivary hypersecretion	14.26	9.77	5	148239	12108	64338380
Skin necrosis	14.24	9.77	68	148176	14261	64336227
Cough	14.23	9.77	559	147685	301589	64048899
Toxic skin eruption	14.19	9.77	14	148230	19270	64331218
Angina unstable	14.19	9.77	9	148235	15458	64335030
Lethargy	14.18	9.77	103	148141	72491	64277997
Primary effusion lymphoma	14.18	9.77	5	148239	43	64350445
Tuberous sclerosis complex	14.16	9.77	6	148238	88	64350400
Aspartate aminotransferase increased	14.14	9.77	192	148052	119596	64230892
Tricuspid valve incompetence	14.14	9.77	11	148233	16992	64333496
Diffuse large B-cell lymphoma stage III	14.10	9.77	6	148238	89	64350399
Intestinal operation	14.09	9.77	10	148234	422	64350066
Sideroblastic anaemia	14.04	9.77	8	148236	229	64350259
Oral lichen planus	14.01	9.77	12	148232	669	64349819
Palpitations	14.01	9.77	163	148081	104325	64246163
Perirectal abscess	14.00	9.77	19	148225	1794	64348694
Necrosis	13.99	9.77	46	148198	8125	64342363
Rectal cancer	13.99	9.77	24	148220	2782	64347706
Fungal peritonitis	13.94	9.77	14	148230	957	64349531
Whipple's disease	13.91	9.77	4	148240	16	64350472
Ureteral neoplasm	13.91	9.77	4	148240	16	64350472
Pulmonary paracoccidioidomycosis	13.91	9.77	4	148240	16	64350472
Tenosynovitis	13.89	9.77	59	148185	11774	64338714
Failed induction of labour	13.89	9.77	8	148236	234	64350254
Gastrointestinal scarring	13.89	9.77	8	148236	234	64350254
Blood potassium increased	13.84	9.77	24	148220	25956	64324532
Adverse reaction	13.82	9.77	44	148200	7643	64342845
Dysphagia	13.79	9.77	168	148076	106644	64243844
Anal squamous cell carcinoma	13.72	9.77	10	148234	440	64350048
Retinal vasculitis	13.72	9.77	15	148229	1132	64349356
Pulmonary congestion	13.71	9.77	21	148223	23859	64326629
Cervix carcinoma	13.71	9.77	19	148225	1829	64348659
Parkinsonism	13.69	9.77	8	148236	14365	64336123
Rhinitis	13.68	9.77	55	148189	10710	64339778
Toxic epidermal necrolysis	13.61	9.77	42	148202	37124	64313364
Polyuria	13.60	9.77	6	148238	12637	64337851
Drug withdrawal syndrome neonatal	13.58	9.77	8	148236	244	64350244
Skin exfoliation	13.58	9.77	55	148189	44830	64305658
Throat cancer	13.54	9.77	14	148230	991	64349497
Foetal exposure during pregnancy	13.48	9.77	31	148213	4445	64346043
Oesophagitis	13.43	9.77	18	148226	21612	64328876
Acne	13.41	9.77	95	148149	22986	64327502
Transplant failure	13.39	9.77	28	148216	3766	64346722
Butterfly rash	13.35	9.77	15	148229	1167	64349321
Anovulatory cycle	13.31	9.77	6	148238	103	64350385
Drug specific antibody	13.30	9.77	20	148224	2075	64348413
Anastomotic stenosis	13.26	9.77	10	148234	464	64350024
Oesophagopleural fistula	13.26	9.77	5	148239	53	64350435
Thinking abnormal	13.21	9.77	5	148239	11551	64338937
Peritoneal candidiasis	13.19	9.77	4	148240	20	64350468
Skin hyperpigmentation	13.18	9.77	39	148205	6512	64343976
Enterostomy closure	13.16	9.77	3	148241	3	64350485
Antineutrophil cytoplasmic antibody decreased	13.16	9.77	3	148241	3	64350485
Precursor T-lymphoblastic lymphoma/leukaemia stage I	13.16	9.77	3	148241	3	64350485
Faecaluria	13.16	9.77	3	148241	3	64350485
Swollen tongue	13.16	9.77	39	148205	34915	64315573
Mediastinal effusion	13.09	9.77	5	148239	55	64350433
Small intestinal resection	13.09	9.77	12	148232	732	64349756
Hepatic fibrosis	13.08	9.77	35	148209	5517	64344971
Skin mass	13.07	9.77	41	148203	7065	64343423
Trichosporon infection	13.06	9.77	13	148231	879	64349609
Immunodeficiency common variable	13.05	9.77	8	148236	263	64350225
Metastatic malignant melanoma	13.02	9.77	22	148222	2519	64347969
Varicella zoster pneumonia	13.00	9.77	6	148238	109	64350379
Mycobacterium chelonae infection	13.00	9.77	20	148224	2117	64348371
Ear infection	12.83	9.77	95	148149	23309	64327179
Acute respiratory failure	12.82	9.77	65	148179	49869	64300619
Renal injury	12.81	9.77	10	148234	15419	64335069
Rectal tenesmus	12.78	9.77	14	148230	1059	64349429
Small intestinal perforation	12.77	9.77	22	148222	2558	64347930
Aspiration	12.73	9.77	12	148232	16873	64333615
Femoral artery aneurysm	12.72	9.77	7	148237	187	64350301
Peripheral artery aneurysm	12.68	9.77	9	148235	380	64350108
Adenocarcinoma of colon	12.65	9.77	32	148212	4876	64345612
Gastroenterostomy	12.63	9.77	5	148239	61	64350427
Foetal malpresentation	12.63	9.77	5	148239	61	64350427
Deep vein thrombosis	12.63	9.77	168	148076	105014	64245474
Nervousness	12.62	9.77	31	148213	29525	64320963
Skin striae	12.61	9.77	16	148228	1414	64349074
Abdominal pain upper	12.60	9.77	306	147938	174724	64175764
Laser therapy	12.58	9.77	4	148240	24	64350464
Hot flush	12.56	9.77	59	148185	46176	64304312
Impetigo	12.56	9.77	18	148226	1788	64348700
Premature baby	12.55	9.77	25	148219	3247	64347241
DNA antibody positive	12.52	9.77	8	148236	283	64350205
Myelitis transverse	12.52	9.77	17	148227	1606	64348882
Ocular toxicity	12.51	9.77	11	148233	635	64349853
Cardiotoxicity	12.51	9.77	4	148240	10270	64340218
Blood creatine phosphokinase increased	12.47	9.77	81	148163	58477	64292011
Hyperlipidaemia	12.45	9.77	21	148223	22955	64327533
Burkitt's lymphoma	12.43	9.77	6	148238	121	64350367
Needle issue	12.43	9.77	3	148241	9269	64341219
Injection site haemorrhage	12.42	9.77	23	148221	24255	64326233
Gastrointestinal ulcer	12.41	9.77	24	148220	3051	64347437
Anal ulcer	12.40	9.77	14	148230	1095	64349393
Herpes virus infection	12.40	9.77	37	148207	6207	64344281
Graft complication	12.37	9.77	11	148233	645	64349843
Pseudopolyposis	12.34	9.77	5	148239	65	64350423
Renal cell carcinoma stage III	12.31	9.77	4	148240	26	64350462
Gastrointestinal dilation procedure	12.30	9.77	3	148241	5	64350483
Pulmonary function test increased	12.30	9.77	3	148241	5	64350483
Diaphragmatic injury	12.30	9.77	6	148238	124	64350364
Kidney fibrosis	12.27	9.77	24	148220	3077	64347411
Mycoplasma test positive	12.23	9.77	7	148237	202	64350286
Cyanosis	12.23	9.77	20	148224	22135	64328353
Adjustment disorder with depressed mood	12.23	9.77	21	148223	2436	64348052
Blood urea increased	12.20	9.77	56	148188	44097	64306391
Sleep apnoea syndrome	12.19	9.77	32	148212	29800	64320688
Haemolysis	12.16	9.77	54	148190	10985	64339503
Rash pustular	12.16	9.77	50	148194	9835	64340653
Cutaneous lupus erythematosus	12.16	9.77	22	148222	2660	64347828
Electrocardiogram abnormal	12.15	9.77	8	148236	13473	64337015
Pneumonitis	12.13	9.77	67	148177	50298	64300190
Dysphonia	12.13	9.77	60	148184	46322	64304166
Hirsutism	12.12	9.77	13	148231	960	64349528
Atypical mycobacterial infection	12.12	9.77	15	148229	1293	64349195
Iron deficiency anaemia	12.08	9.77	89	148155	21800	64328688
Deafness transitory	12.06	9.77	12	148232	811	64349677
Acute coronary syndrome	12.06	9.77	16	148228	19294	64331194
Herpes simplex colitis	12.06	9.77	4	148240	28	64350460
Transaminases increased	12.03	9.77	156	148088	44438	64306050
Psychotic disorder	12.02	9.77	40	148204	34538	64315950
Diabetes mellitus inadequate control	12.01	9.77	19	148225	21302	64329186
Infective tenosynovitis	11.99	9.77	8	148236	305	64350183
Cerebral infarction	11.98	9.77	51	148193	40993	64309495
Anaplastic large cell lymphoma T- and null-cell types stage III	11.95	9.77	3	148241	6	64350482
Actinic cheilitis	11.95	9.77	3	148241	6	64350482
Cryoglobulins present	11.95	9.77	3	148241	6	64350482
Cholangitis chronic	11.94	9.77	4	148240	29	64350459
Peripheral swelling	11.89	9.77	378	147866	208775	64141713
Epstein-Barr virus infection reactivation	11.83	9.77	14	148230	1152	64349336
Subarachnoid haemorrhage	11.80	9.77	15	148229	18423	64332065
Vascular graft complication	11.80	9.77	6	148238	136	64350352
Gingival hypertrophy	11.78	9.77	22	148222	2725	64347763
Faeces discoloured	11.77	9.77	26	148218	25703	64324785
Thrombotic microangiopathy	11.77	9.77	72	148172	16583	64333905
Renal tubular atrophy	11.77	9.77	16	148228	1513	64348975
Injection site induration	11.76	9.77	3	148241	8929	64341559
Enterocolonic fistula	11.76	9.77	6	148238	137	64350351
Arteriosclerosis coronary artery	11.75	9.77	11	148233	15518	64334970
Pyoderma	11.74	9.77	8	148236	316	64350172
Ileostomy closure	11.72	9.77	6	148238	138	64350350
Vitamin B1 decreased	11.72	9.77	8	148236	317	64350171
Eosinophilic myocarditis	11.71	9.77	12	148232	840	64349648
Threatened labour	11.71	9.77	10	148234	555	64349933
Cytopenia	11.65	9.77	68	148176	15403	64335085
Spindle cell sarcoma	11.64	9.77	7	148237	222	64350266
Paradoxical psoriasis	11.60	9.77	6	148238	141	64350347
Metastases to central nervous system	11.57	9.77	9	148235	13903	64336585
Second primary malignancy	11.57	9.77	7	148237	12330	64338158
Abdominal pain lower	11.55	9.77	102	148142	26367	64324121
Gastrointestinal motility disorder	11.55	9.77	32	148212	5147	64345341
Small intestine adenocarcinoma	11.52	9.77	6	148238	143	64350345
Total bile acids increased	11.52	9.77	5	148239	78	64350410
Product dispensing error	11.45	9.77	6	148238	11444	64339044
Diarrhoea	11.44	9.77	1471	146773	721233	63629255
Ophthalmic herpes simplex	11.43	9.77	10	148234	574	64349914
Cerebral fungal infection	11.41	9.77	8	148236	331	64350157
Cleft lip and palate	11.41	9.77	5	148239	80	64350408
Joint dislocation reduction	11.38	9.77	4	148240	34	64350454
Lacrimal haemorrhage	11.38	9.77	4	148240	34	64350454
Overgrowth bacterial	11.37	9.77	6	148238	147	64350341
Molluscum contagiosum	11.37	9.77	9	148235	449	64350039
Pulmonary thrombosis	11.30	9.77	5	148239	10513	64339975
Fasting	11.28	9.77	4	148240	35	64350453
Tumour lysis syndrome	11.26	9.77	17	148227	19423	64331065
Presyncope	11.25	9.77	42	148202	35047	64315441
Germ cell cancer	11.23	9.77	6	148238	151	64350337
Psychomotor hyperactivity	11.21	9.77	10	148234	14441	64336047
Stoma complication	11.16	9.77	9	148235	461	64350027
Gastric fistula	11.16	9.77	6	148238	153	64350335
Alanine aminotransferase increased	11.15	9.77	239	148005	138792	64211696
Renal failure	11.15	9.77	325	147919	181363	64169125
Parvovirus B19 infection	11.14	9.77	14	148230	1225	64349263
COVID-19	11.13	9.77	211	148033	64929	64285559
Idiopathic pulmonary fibrosis	11.10	9.77	26	148218	3774	64346714
Tonsillitis	11.10	9.77	34	148210	5786	64344702
Hepatobiliary cancer	11.10	9.77	3	148241	9	64350479
Neuropsychiatric lupus	11.09	9.77	6	148238	155	64350333
Klebsiella infection	11.08	9.77	60	148184	13221	64337267
Rheumatoid factor positive	11.07	9.77	126	148118	34812	64315676
Iron deficiency	11.06	9.77	39	148205	7138	64343350
Complication associated with device	11.04	9.77	11	148233	15069	64335419
Pharyngitis bacterial	11.02	9.77	7	148237	245	64350243
Peritoneal abscess	11.02	9.77	7	148237	245	64350243
Toxoplasmosis	11.02	9.77	20	148224	2424	64348064
Abnormal dreams	11.00	9.77	5	148239	10351	64340137
Gastrointestinal disorder	10.98	9.77	277	147967	89432	64261056
Relapsing fever	10.98	9.77	8	148236	352	64350136
Renal transplant	10.91	9.77	19	148225	2229	64348259
Panniculitis lobular	10.90	9.77	4	148240	39	64350449
Oropharyngeal squamous cell carcinoma	10.90	9.77	7	148237	250	64350238
Cholestasis	10.89	9.77	154	148090	44718	64305770
Coordination abnormal	10.86	9.77	11	148233	14953	64335535
Amniotic cavity infection	10.82	9.77	11	148233	763	64349725
Cryptococcal cutaneous infection	10.81	9.77	6	148238	163	64350325
Cardiomegaly	10.78	9.77	24	148220	23660	64326828
Haematuria	10.78	9.77	88	148156	60383	64290105
Pneumonia herpes viral	10.75	9.77	6	148238	165	64350323
Generalised tonic-clonic seizure	10.74	9.77	51	148193	39806	64310682
Injection site reaction	10.74	9.77	63	148181	46601	64303887
Gastroenteritis clostridial	10.73	9.77	11	148233	771	64349717
Vascular shunt	10.72	9.77	4	148240	41	64350447
Superinfection viral	10.72	9.77	4	148240	41	64350447
Burkholderia pseudomallei infection	10.72	9.77	4	148240	41	64350447
Renal atrophy	10.72	9.77	16	148228	1648	64348840
Erectile dysfunction	10.72	9.77	8	148236	12619	64337869
Mania	10.69	9.77	13	148231	16273	64334215
Spondyloarthropathy	10.68	9.77	11	148233	775	64349713
Colonic abscess	10.67	9.77	13	148231	1102	64349386
Fibroadenoma of breast	10.65	9.77	7	148237	260	64350228
Cushing's syndrome	10.62	9.77	12	148232	939	64349549
Tuberculosis gastrointestinal	10.61	9.77	9	148235	495	64349993
Lupus endocarditis	10.55	9.77	6	148238	171	64350317
Otorrhoea	10.53	9.77	15	148229	1482	64349006
Upper respiratory tract irritation	10.49	9.77	5	148239	98	64350390
Enterobacter infection	10.48	9.77	25	148219	3671	64346817
Infected fistula	10.47	9.77	7	148237	268	64350220
Device leakage	10.46	9.77	3	148241	8263	64342225
Telangiectasia	10.46	9.77	13	148231	1125	64349363
Dystonia	10.44	9.77	17	148227	18848	64331640
Paraproteinaemia	10.44	9.77	8	148236	380	64350108
Laryngeal stenosis	10.44	9.77	11	148233	796	64349692
Diffuse large B-cell lymphoma stage I	10.43	9.77	3	148241	12	64350476
Hepatic angiosarcoma	10.43	9.77	3	148241	12	64350476
Uveal melanoma	10.43	9.77	3	148241	12	64350476
Myelitis	10.43	9.77	18	148226	2096	64348392
Dengue fever	10.43	9.77	11	148233	797	64349691
Lower gastrointestinal haemorrhage	10.40	9.77	10	148234	13929	64336559
Intestinal polyp	10.39	9.77	16	148228	1695	64348793
Sudden death	10.31	9.77	19	148225	20077	64330411
Cutaneous nocardiosis	10.31	9.77	6	148238	179	64350309
Incorrect route of product administration	10.29	9.77	24	148220	23274	64327214
Oedema	10.26	9.77	149	148095	91786	64258702
Central nervous system necrosis	10.26	9.77	7	148237	277	64350211
Hepatitis chronic active	10.25	9.77	6	148238	181	64350307
Infusion site paraesthesia	10.24	9.77	3	148241	13	64350475
Meningeal neoplasm	10.24	9.77	3	148241	13	64350475
Spleen palpable	10.24	9.77	3	148241	13	64350475
Superficial spreading melanoma stage unspecified	10.24	9.77	7	148237	278	64350210
Feeling jittery	10.23	9.77	50	148194	10585	64339903
Mood altered	10.23	9.77	13	148231	15966	64334522
Gastric ulcer haemorrhage	10.22	9.77	3	148241	8140	64342348
Post transplant distal limb syndrome	10.22	9.77	9	148235	521	64349967
Tinnitus	10.21	9.77	42	148202	34091	64316397
Peritonitis	10.20	9.77	95	148149	24928	64325560
Infective aortitis	10.16	9.77	4	148240	48	64350440
Akathisia	10.15	9.77	7	148237	11503	64338985
Testicular abscess	10.09	9.77	4	148240	49	64350439
Tuberculosis of eye	10.09	9.77	4	148240	49	64350439
Hypoaesthesia	10.07	9.77	243	148001	138865	64211623
Burkholderia cepacia complex infection	10.06	9.77	7	148237	286	64350202
Pulmonary venous thrombosis	10.05	9.77	5	148239	108	64350380
Blood pressure abnormal	10.04	9.77	11	148233	14424	64336064
Aspiration bone marrow	10.02	9.77	4	148240	50	64350438
Vertigo	10.01	9.77	87	148157	58924	64291564
Renal phospholipidosis	10.01	9.77	5	148239	109	64350379
Blood glucose abnormal	9.95	9.77	4	148240	8909	64341579
Photophobia	9.94	9.77	71	148173	17222	64333266
Burning sensation	9.92	9.77	70	148174	49594	64300894
Bursitis infective	9.91	9.77	13	148231	1187	64349301
Liver sarcoidosis	9.89	9.77	3	148241	15	64350473
Conjunctivochalasis	9.89	9.77	3	148241	15	64350473
Metastases to nasal sinuses	9.89	9.77	3	148241	15	64350473
Therapeutic response unexpected	9.89	9.77	70	148174	16931	64333557
Muir-Torre syndrome	9.88	9.77	4	148240	52	64350436
Rotator cuff syndrome	9.86	9.77	8	148236	12099	64338389
Pseudolymphoma	9.86	9.77	12	148232	1017	64349471
Conjunctivitis allergic	9.85	9.77	12	148232	1018	64349470
Viral sepsis	9.84	9.77	5	148239	113	64350375
Hepatitis E	9.84	9.77	19	148225	2412	64348076
Gastrointestinal stoma output decreased	9.81	9.77	4	148240	53	64350435
Koebner phenomenon	9.81	9.77	4	148240	53	64350435
Isosporiasis	9.80	9.77	5	148239	114	64350374
Allergy to chemicals	9.78	9.77	12	148232	1025	64349463
Acute pulmonary oedema	9.78	9.77	9	148235	12800	64337688

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hydrops foetalis	56.23	32.05	17	194	80	84387

Pharmacologic Action:

Source	Code	Description
ATC	L04AX01	ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS IMMUNOSUPPRESSANTS IMMUNOSUPPRESSANTS Other immunosuppressants
FDA CS	M0015066	Nucleosides
FDA CS	M0018169	Purines
FDA MoA	N0000000233	Nucleic Acid Synthesis Inhibitors
MeSH PA	D000963	Antimetabolites
MeSH PA	D000964	Antimetabolites, Antineoplastic
MeSH PA	D000970	Antineoplastic Agents
MeSH PA	D018501	Antirheumatic Agents
MeSH PA	D007155	Immunologic Factors
MeSH PA	D007166	Immunosuppressive Agents
MeSH PA	D009676	Noxae
FDA EPC	N0000175712	Purine Antimetabolite

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Refractory idiopathic thrombocytopenic purpura	indication	13172003
Relapsing multiple sclerosis	indication	24700007	DOID:2377
Crohn's disease	indication	34000006
Pemphigus vulgaris	indication	49420001	DOID:0060851
Systemic lupus erythematosus	indication	55464009	DOID:9074
Ulcerative colitis	indication	64766004	DOID:8577
Rheumatoid arthritis	indication	69896004	DOID:7148
Bullous pemphigoid	indication	77090002	DOID:8506
Myasthenia gravis	indication	91637004	DOID:437
Polyarteritis nodosa	indication	155441006	DOID:9810
Behcet's disease	indication	310701003	DOID:13241
Dermatomyositis	indication	396230008	DOID:10223
Autoimmune hepatitis	indication	408335007
Refractory autoimmune haemolytic anaemia	indication	413603009	DOID:718
Prevention of Kidney Transplant Rejection	indication
Polymyositis	off-label use	31384009
Prevention of Lung Transplant Rejection	off-label use
Prevention of Cardiac Transplant Rejection	off-label use
Prevention of Liver Transplant Rejection	off-label use
Mycosis	contraindication	3218000	DOID:1564
Viral disease	contraindication	34014006	DOID:934
Hepatic vein thrombosis	contraindication	38739001	DOID:11512
Bacterial infectious disease	contraindication	87628006
Malignant lymphoma	contraindication	118600007	DOID:0060058
Liver function tests abnormal	contraindication	166603001
Acute pancreatitis	contraindication	197456007	DOID:2913
Impaired renal function disorder	contraindication	197663003
Anemia	contraindication	271737000	DOID:2355
Pregnancy, function	contraindication	289908002
Thrombocytopenic disorder	contraindication	302215000	DOID:1588
Bone marrow depression	contraindication	307762000
Hepatosplenic T-cell lymphoma	contraindication	445406001
Thiopurine S-Methyltransferase Deficiency	contraindication
Severe Leukopenia	contraindication
Protozoal Infection	contraindication

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	8.28	acidic
pKa2	3.24	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Bioact source
ATP-binding cassette sub-family G member 2	Transporter	Q9UNQ0	ABCG2_HUMAN	WOMBAT-PK
Multidrug resistance-associated protein 5	Transporter	O15440	MRP5_HUMAN	WOMBAT-PK
Multidrug resistance-associated protein 4	Transporter	O15439	MRP4_HUMAN	WOMBAT-PK
Ras-related C3 botulinum toxin substrate 1	Enzyme	P63000	RAC1_HUMAN	WOMBAT-PK
Thiopurine S-methyltransferase	Enzyme	P51580	TPMT_HUMAN	WOMBAT-PK

External reference:

ID	Source
4018766	VUID
N0000147069	NUI
D00238	KEGG_DRUG
55774-33-9	SECONDARY_CAS_RN
1256	RXNORM
C0004482	UMLSCUI
CHEMBL1542	ChEMBL_ID
DB00993	DRUGBANK_ID
CHEMBL1200400	ChEMBL_ID
D001379	MESH_DESCRIPTOR_UI
2265	PUBCHEM_CID
7120	IUPHAR_LIGAND_ID
1291	INN_ID
MRK240IY2L	UNII
3341	MMSL
4234	MMSL
4235	MMSL
6041	MMSL
d00024	MMSL
003419	NDDF
004123	NDDF
4018766	VANDF
111165009	SNOMEDCT_US
372574004	SNOMEDCT_US
67221004	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Azathioprine Sodium	HUMAN PRESCRIPTION DRUG LABEL	1	0143-9566	INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION	100 mg	INTRAVENOUS	ANDA	22 sections
Azathioprine	HUMAN PRESCRIPTION DRUG LABEL	1	0378-1005	TABLET	50 mg	ORAL	ANDA	23 sections
Azathioprine	HUMAN PRESCRIPTION DRUG LABEL	1	21695-484	TABLET	50 mg	ORAL	ANDA	20 sections
Azathioprine	HUMAN PRESCRIPTION DRUG LABEL	1	33261-758	TABLET	50 mg	ORAL	ANDA	20 sections
AZATHIOPRINE	HUMAN PRESCRIPTION DRUG LABEL	1	42291-071	TABLET	50 mg	ORAL	ANDA	19 sections
Azathioprine	HUMAN PRESCRIPTION DRUG LABEL	1	43353-745	TABLET	50 mg	ORAL	ANDA	23 sections
Azathioprine	HUMAN PRESCRIPTION DRUG LABEL	1	51407-182	TABLET	50 mg	ORAL	ANDA	14 sections
IMURAN	HUMAN PRESCRIPTION DRUG LABEL	1	54766-590	TABLET	50 mg	ORAL	NDA	23 sections
Azathioprine	HUMAN PRESCRIPTION DRUG LABEL	1	54868-5310	TABLET	50 mg	ORAL	ANDA	20 sections
AZATHIOPRINE	HUMAN PRESCRIPTION DRUG LABEL	1	60219-1076	TABLET	50 mg	ORAL	ANDA	19 sections
AZATHIOPRINE	HUMAN PRESCRIPTION DRUG LABEL	1	60219-2036	TABLET	75 mg	ORAL	ANDA	19 sections
AZATHIOPRINE	HUMAN PRESCRIPTION DRUG LABEL	1	60219-2037	TABLET	100 mg	ORAL	ANDA	19 sections
IMURAN	HUMAN PRESCRIPTION DRUG LABEL	1	65483-590	TABLET	50 mg	ORAL	NDA	23 sections
Azasan	HUMAN PRESCRIPTION DRUG LABEL	1	65649-231	TABLET	75 mg	ORAL	ANDA	13 sections
Azasan	HUMAN PRESCRIPTION DRUG LABEL	1	65649-241	TABLET	100 mg	ORAL	ANDA	13 sections
Azathioprine	HUMAN PRESCRIPTION DRUG LABEL	1	65841-602	TABLET	50 mg	ORAL	ANDA	1 sections
Azathioprine	Human Prescription Drug Label	1	67877-492	TABLET	25 mg	ORAL	ANDA	21 sections
Azathioprine	Human Prescription Drug Label	1	67877-492	TABLET	25 mg	ORAL	ANDA	21 sections
Azathioprine	Human Prescription Drug Label	1	67877-493	TABLET	50 mg	ORAL	ANDA	21 sections
Azathioprine	Human Prescription Drug Label	1	67877-493	TABLET	50 mg	ORAL	ANDA	21 sections
Azathioprine	Human Prescription Drug Label	1	67877-494	TABLET	75 mg	ORAL	ANDA	21 sections
Azathioprine	Human Prescription Drug Label	1	67877-494	TABLET	75 mg	ORAL	ANDA	21 sections
Azathioprine	Human Prescription Drug Label	1	67877-495	TABLET	100 mg	ORAL	ANDA	21 sections
Azathioprine	Human Prescription Drug Label	1	67877-495	TABLET	100 mg	ORAL	ANDA	21 sections
Azathioprine	HUMAN PRESCRIPTION DRUG LABEL	1	68084-229	TABLET	50 mg	ORAL	ANDA	20 sections
Azathioprine	HUMAN PRESCRIPTION DRUG LABEL	1	68382-003	TABLET	50 1	ORAL	ANDA	20 sections
Azathioprine	HUMAN PRESCRIPTION DRUG LABEL	1	68382-118	TABLET	25 1	ORAL	ANDA	20 sections
Azathioprine	HUMAN PRESCRIPTION DRUG LABEL	1	68382-119	TABLET	75 1	ORAL	ANDA	20 sections
Azathioprine	HUMAN PRESCRIPTION DRUG LABEL	1	68382-120	TABLET	100 1	ORAL	ANDA	20 sections
Azathioprine	HUMAN PRESCRIPTION DRUG LABEL	1	68462-502	TABLET	50 mg	ORAL	ANDA	14 sections