Stem definition | Drug id | CAS RN |
---|---|---|
269 | 446-86-6 |
Dose | Unit | Route |
---|---|---|
0.15 | g | O |
0.15 | g | P |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 10 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 1 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 18.03 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 60 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Date | Agency | Company | Orphan |
---|---|---|---|
March 20, 1968 | FDA | PROMETHEUS LABS | |
Feb. 21, 2019 | PMDA | ASPEN JAPAN K.K.; MITSUBISHI TANABE PHARMA CORPORATION |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Drug ineffective | 609.46 | 9.85 | 3320 | 107977 | 813925 | 52423844 |
Blood iron abnormal | 547.51 | 9.85 | 220 | 111077 | 3107 | 53234662 |
Off label use | 528.80 | 9.85 | 2162 | 109135 | 470050 | 52767719 |
Colitis ulcerative | 514.76 | 9.85 | 394 | 110903 | 20667 | 53217102 |
Exposure during pregnancy | 507.14 | 9.85 | 923 | 110374 | 123937 | 53113832 |
Drug intolerance | 429.82 | 9.85 | 1164 | 110133 | 204329 | 53033440 |
Treatment failure | 338.95 | 9.85 | 795 | 110502 | 127608 | 53110161 |
Crohn's disease | 260.20 | 9.85 | 167 | 111130 | 6583 | 53231186 |
Product use in unapproved indication | 243.29 | 9.85 | 645 | 110652 | 111644 | 53126125 |
Premature delivery | 239.73 | 9.85 | 284 | 111013 | 25820 | 53211949 |
Death | 232.20 | 9.85 | 242 | 111055 | 356990 | 52880779 |
Cytomegalovirus infection | 224.66 | 9.85 | 239 | 111058 | 19300 | 53218469 |
Intestinal stenosis | 222.55 | 9.85 | 110 | 111187 | 2591 | 53235178 |
Rheumatoid arthritis | 209.48 | 9.85 | 1244 | 110053 | 313287 | 52924482 |
Cushingoid | 192.40 | 9.85 | 142 | 111155 | 7040 | 53230729 |
Fall | 189.80 | 9.85 | 284 | 111013 | 358156 | 52879613 |
Fistula | 176.22 | 9.85 | 147 | 111150 | 8723 | 53229046 |
Lupus-like syndrome | 175.46 | 9.85 | 149 | 111148 | 9063 | 53228706 |
Demyelination | 168.80 | 9.85 | 124 | 111173 | 6103 | 53231666 |
SLE arthritis | 167.60 | 9.85 | 60 | 111237 | 603 | 53237166 |
Bone erosion | 166.10 | 9.85 | 157 | 111140 | 10995 | 53226774 |
Anal fistula | 164.75 | 9.85 | 92 | 111205 | 2799 | 53234970 |
Ileal stenosis | 164.70 | 9.85 | 75 | 111222 | 1461 | 53236308 |
Condition aggravated | 161.18 | 9.85 | 1116 | 110181 | 296018 | 52941751 |
Fatigue | 157.11 | 9.85 | 890 | 110407 | 729616 | 52508153 |
Drug level below therapeutic | 155.47 | 9.85 | 97 | 111200 | 3636 | 53234133 |
Premature labour | 150.65 | 9.85 | 156 | 111141 | 12206 | 53225563 |
Post transplant lymphoproliferative disorder | 148.64 | 9.85 | 100 | 111197 | 4271 | 53233498 |
Therapeutic response decreased | 138.01 | 9.85 | 306 | 110991 | 47263 | 53190506 |
Proteinuria | 134.54 | 9.85 | 177 | 111120 | 17891 | 53219878 |
Frequent bowel movements | 134.29 | 9.85 | 158 | 111139 | 14254 | 53223515 |
Elbow deformity | 133.05 | 9.85 | 63 | 111234 | 1346 | 53236423 |
Maternal exposure during pregnancy | 131.95 | 9.85 | 658 | 110639 | 154981 | 53082788 |
Disease recurrence | 131.57 | 9.85 | 189 | 111108 | 20757 | 53217012 |
Cholestasis of pregnancy | 129.53 | 9.85 | 59 | 111238 | 1150 | 53236619 |
Epstein-Barr virus infection | 129.17 | 9.85 | 114 | 111183 | 7304 | 53230465 |
Therapeutic product effect incomplete | 128.87 | 9.85 | 453 | 110844 | 91331 | 53146438 |
Intestinal resection | 128.56 | 9.85 | 73 | 111224 | 2295 | 53235474 |
Large intestinal stenosis | 126.14 | 9.85 | 66 | 111231 | 1758 | 53236011 |
Hyponatraemia | 122.69 | 9.85 | 37 | 111260 | 108570 | 53129199 |
Transplant rejection | 118.15 | 9.85 | 125 | 111172 | 10026 | 53227743 |
Faecal calprotectin increased | 117.18 | 9.85 | 66 | 111231 | 2042 | 53235727 |
Lupus nephritis | 117.04 | 9.85 | 70 | 111227 | 2429 | 53235340 |
Product dose omission issue | 114.23 | 9.85 | 139 | 111158 | 191481 | 53046288 |
Intentional product use issue | 112.47 | 9.85 | 370 | 110927 | 72124 | 53165645 |
Vasculitis | 112.23 | 9.85 | 147 | 111150 | 14793 | 53222976 |
Glossodynia | 111.78 | 9.85 | 35 | 111262 | 100256 | 53137513 |
Abortion spontaneous | 109.22 | 9.85 | 276 | 111021 | 46359 | 53191410 |
Somnolence | 108.32 | 9.85 | 114 | 111183 | 167620 | 53070149 |
Confusional state | 107.42 | 9.85 | 149 | 111148 | 194072 | 53043697 |
Kidney transplant rejection | 107.18 | 9.85 | 81 | 111216 | 4163 | 53233606 |
Impaired gastric emptying | 106.40 | 9.85 | 112 | 111185 | 8931 | 53228838 |
Anal abscess | 103.72 | 9.85 | 77 | 111220 | 3851 | 53233918 |
Toxicity to various agents | 103.00 | 9.85 | 188 | 111109 | 219410 | 53018359 |
Arthritis | 102.63 | 9.85 | 407 | 110890 | 86891 | 53150878 |
Malignant neoplasm progression | 102.20 | 9.85 | 14 | 111283 | 71527 | 53166242 |
Product use issue | 101.69 | 9.85 | 566 | 110731 | 139018 | 53098751 |
Pre-eclampsia | 99.79 | 9.85 | 106 | 111191 | 8541 | 53229228 |
Therapeutic product effect decreased | 97.93 | 9.85 | 519 | 110778 | 125136 | 53112633 |
Pain | 97.04 | 9.85 | 775 | 110522 | 587623 | 52650146 |
Haemophagocytic lymphohistiocytosis | 94.97 | 9.85 | 106 | 111191 | 9031 | 53228738 |
Haematochezia | 93.32 | 9.85 | 245 | 111052 | 42113 | 53195656 |
Drug abuse | 90.87 | 9.85 | 14 | 111283 | 65512 | 53172257 |
Abscess | 89.73 | 9.85 | 133 | 111164 | 15023 | 53222746 |
Overdose | 88.32 | 9.85 | 58 | 111239 | 107678 | 53130091 |
Hypotension | 88.08 | 9.85 | 256 | 111041 | 253820 | 52983949 |
Antinuclear antibody positive | 87.64 | 9.85 | 88 | 111209 | 6637 | 53231132 |
Atrial fibrillation | 86.38 | 9.85 | 64 | 111233 | 111588 | 53126181 |
Cerebrovascular accident | 85.70 | 9.85 | 57 | 111240 | 105117 | 53132652 |
Ankylosing spondylitis | 84.00 | 9.85 | 94 | 111203 | 8031 | 53229738 |
Dizziness | 83.74 | 9.85 | 446 | 110851 | 371813 | 52865956 |
Inflammation | 83.63 | 9.85 | 286 | 111011 | 56850 | 53180919 |
Electrocardiogram QT prolonged | 83.07 | 9.85 | 10 | 111287 | 56393 | 53181376 |
Constipation | 82.62 | 9.85 | 182 | 111115 | 198230 | 53039539 |
Lung transplant rejection | 81.94 | 9.85 | 38 | 111259 | 773 | 53236996 |
Cardiac failure congestive | 81.52 | 9.85 | 46 | 111251 | 92711 | 53145058 |
Drug hypersensitivity | 80.23 | 9.85 | 876 | 110421 | 264366 | 52973403 |
Abdominal pain | 79.65 | 9.85 | 850 | 110447 | 255053 | 52982716 |
Hepatic cirrhosis | 79.09 | 9.85 | 138 | 111159 | 17884 | 53219885 |
Cytomegalovirus viraemia | 77.66 | 9.85 | 72 | 111225 | 4919 | 53232850 |
Granulomatosis with polyangiitis | 77.47 | 9.85 | 50 | 111247 | 1989 | 53235780 |
Squamous cell carcinoma | 77.17 | 9.85 | 90 | 111207 | 8042 | 53229727 |
Pleuritic pain | 76.87 | 9.85 | 83 | 111214 | 6813 | 53230956 |
Pancreatitis | 76.53 | 9.85 | 241 | 111056 | 45901 | 53191868 |
Diffuse large B-cell lymphoma | 76.07 | 9.85 | 81 | 111216 | 6544 | 53231225 |
Gestational hypertension | 76.05 | 9.85 | 52 | 111245 | 2281 | 53235488 |
Pancytopenia | 75.97 | 9.85 | 383 | 110914 | 90545 | 53147224 |
Red blood cell sedimentation rate increased | 75.25 | 9.85 | 175 | 111122 | 27882 | 53209887 |
Hepatosplenic T-cell lymphoma | 74.63 | 9.85 | 33 | 111264 | 598 | 53237171 |
Osteoporosis | 74.63 | 9.85 | 240 | 111057 | 46220 | 53191549 |
Anaphylactic reaction | 74.31 | 9.85 | 279 | 111018 | 58047 | 53179722 |
Disseminated tuberculosis | 73.33 | 9.85 | 55 | 111242 | 2794 | 53234975 |
Nonalcoholic fatty liver disease | 72.80 | 9.85 | 38 | 111259 | 1007 | 53236762 |
Leukopenia | 72.69 | 9.85 | 325 | 110972 | 73138 | 53164631 |
Basal cell carcinoma | 72.63 | 9.85 | 155 | 111142 | 23314 | 53214455 |
Normal newborn | 72.42 | 9.85 | 82 | 111215 | 7097 | 53230672 |
Autoimmune hepatitis | 72.25 | 9.85 | 88 | 111209 | 8230 | 53229539 |
Arthralgia | 72.24 | 9.85 | 1303 | 109994 | 438480 | 52799289 |
Diarrhoea haemorrhagic | 72.23 | 9.85 | 88 | 111209 | 8232 | 53229537 |
Tremor | 71.97 | 9.85 | 94 | 111203 | 125642 | 53112127 |
Asthenia | 71.62 | 9.85 | 422 | 110875 | 343168 | 52894601 |
Exostosis | 71.62 | 9.85 | 103 | 111194 | 11321 | 53226448 |
Rheumatoid nodule | 71.52 | 9.85 | 105 | 111192 | 11759 | 53226010 |
Joint dislocation | 71.18 | 9.85 | 107 | 111190 | 12238 | 53225531 |
Gastrointestinal inflammation | 69.59 | 9.85 | 66 | 111231 | 4640 | 53233129 |
Intestinal obstruction | 69.27 | 9.85 | 172 | 111125 | 28569 | 53209200 |
Decreased appetite | 69.20 | 9.85 | 224 | 111073 | 214750 | 53023019 |
Anti-neutrophil cytoplasmic antibody positive vasculitis | 68.69 | 9.85 | 49 | 111248 | 2302 | 53235467 |
Hair follicle tumour benign | 68.58 | 9.85 | 27 | 111270 | 360 | 53237409 |
Progressive multifocal leukoencephalopathy | 68.33 | 9.85 | 104 | 111193 | 12025 | 53225744 |
Epstein-Barr virus associated lymphoproliferative disorder | 68.08 | 9.85 | 43 | 111254 | 1647 | 53236122 |
Hypokalaemia | 67.60 | 9.85 | 61 | 111236 | 96456 | 53141313 |
Synovial fluid analysis | 67.39 | 9.85 | 43 | 111254 | 1677 | 53236092 |
Scleritis | 67.25 | 9.85 | 56 | 111241 | 3314 | 53234455 |
Anxiety | 66.82 | 9.85 | 200 | 111097 | 196504 | 53041265 |
Premature baby | 66.22 | 9.85 | 135 | 111162 | 19666 | 53218103 |
Pneumocystis jirovecii pneumonia | 66.21 | 9.85 | 121 | 111176 | 16257 | 53221512 |
Tenosynovitis stenosans | 64.91 | 9.85 | 47 | 111250 | 2261 | 53235508 |
Liver function test increased | 64.86 | 9.85 | 160 | 111137 | 26468 | 53211301 |
Joint stiffness | 64.50 | 9.85 | 173 | 111124 | 30110 | 53207659 |
Colectomy | 63.14 | 9.85 | 45 | 111252 | 2111 | 53235658 |
Clostridium difficile infection | 63.14 | 9.85 | 163 | 111134 | 27730 | 53210039 |
Cardio-respiratory arrest | 62.84 | 9.85 | 22 | 111275 | 58736 | 53179033 |
Lymphopenia | 62.56 | 9.85 | 120 | 111177 | 16723 | 53221046 |
Insomnia | 61.55 | 9.85 | 193 | 111104 | 186879 | 53050890 |
Hand deformity | 61.38 | 9.85 | 52 | 111245 | 84797 | 53152972 |
Gastrointestinal lymphoma | 60.71 | 9.85 | 16 | 111281 | 48 | 53237721 |
Syncope | 59.81 | 9.85 | 88 | 111209 | 111905 | 53125864 |
Immunosuppressant drug level decreased | 59.69 | 9.85 | 33 | 111264 | 984 | 53236785 |
Febrile neutropenia | 59.49 | 9.85 | 79 | 111218 | 104857 | 53132912 |
Swelling | 58.84 | 9.85 | 203 | 111094 | 190902 | 53046867 |
Loss of consciousness | 58.82 | 9.85 | 92 | 111205 | 114120 | 53123649 |
Pemphigus | 58.28 | 9.85 | 79 | 111218 | 103952 | 53133817 |
Overlap syndrome | 58.22 | 9.85 | 28 | 111269 | 620 | 53237149 |
Neuromyelitis optica spectrum disorder | 56.96 | 9.85 | 32 | 111265 | 985 | 53236784 |
Blood pressure fluctuation | 56.75 | 9.85 | 183 | 111114 | 35287 | 53202482 |
C-reactive protein abnormal | 56.32 | 9.85 | 149 | 111148 | 25721 | 53212048 |
Abdominal discomfort | 55.87 | 9.85 | 254 | 111043 | 220808 | 53016961 |
Erythema nodosum | 55.41 | 9.85 | 55 | 111242 | 4090 | 53233679 |
Histoplasmosis disseminated | 55.15 | 9.85 | 34 | 111263 | 1247 | 53236522 |
Pulmonary mass | 55.00 | 9.85 | 126 | 111171 | 19878 | 53217891 |
C-reactive protein increased | 54.63 | 9.85 | 283 | 111014 | 67603 | 53170166 |
Hallucination | 54.49 | 9.85 | 22 | 111275 | 53816 | 53183953 |
Lymphoproliferative disorder | 54.41 | 9.85 | 47 | 111250 | 2925 | 53234844 |
Joint swelling | 54.36 | 9.85 | 737 | 110560 | 233901 | 53003868 |
Caesarean section | 54.30 | 9.85 | 115 | 111182 | 17205 | 53220564 |
Hypogammaglobulinaemia | 54.17 | 9.85 | 65 | 111232 | 5985 | 53231784 |
Interstitial lung disease | 54.02 | 9.85 | 254 | 111043 | 58368 | 53179401 |
Diabetes mellitus | 53.72 | 9.85 | 239 | 111058 | 53660 | 53184109 |
Cardiac arrest | 53.62 | 9.85 | 70 | 111227 | 93597 | 53144172 |
Dyspnoea | 53.23 | 9.85 | 882 | 110415 | 585350 | 52652419 |
Contusion | 52.57 | 9.85 | 94 | 111203 | 110638 | 53127131 |
Lupus vasculitis | 52.54 | 9.85 | 24 | 111273 | 471 | 53237298 |
Tuberculosis | 51.50 | 9.85 | 87 | 111210 | 10984 | 53226785 |
Neutrophil count decreased | 51.45 | 9.85 | 19 | 111278 | 49079 | 53188690 |
Discomfort | 50.99 | 9.85 | 75 | 111222 | 95397 | 53142372 |
Agitation | 50.18 | 9.85 | 30 | 111267 | 58596 | 53179173 |
Stomatitis | 49.66 | 9.85 | 80 | 111217 | 98078 | 53139691 |
Pulmonary tuberculosis | 49.65 | 9.85 | 56 | 111241 | 4825 | 53232944 |
Depression | 48.87 | 9.85 | 206 | 111091 | 182846 | 53054923 |
Seizure | 48.16 | 9.85 | 126 | 111171 | 129383 | 53108386 |
Plasma cell myeloma | 47.74 | 9.85 | 20 | 111277 | 47854 | 53189915 |
Ulcer | 47.19 | 9.85 | 121 | 111176 | 20498 | 53217271 |
Intestinal fistula | 47.10 | 9.85 | 26 | 111271 | 773 | 53236996 |
Listeriosis | 46.98 | 9.85 | 32 | 111265 | 1395 | 53236374 |
Drug level decreased | 46.81 | 9.85 | 64 | 111233 | 6710 | 53231059 |
Angiocentric lymphoma | 45.87 | 9.85 | 23 | 111274 | 559 | 53237210 |
Premature separation of placenta | 45.75 | 9.85 | 35 | 111262 | 1832 | 53235937 |
Chronic allograft nephropathy | 45.27 | 9.85 | 24 | 111273 | 657 | 53237112 |
Wound | 45.03 | 9.85 | 76 | 111221 | 91481 | 53146288 |
Epstein-Barr virus test positive | 44.81 | 9.85 | 23 | 111274 | 588 | 53237181 |
Neoplasm progression | 44.81 | 9.85 | 5 | 111292 | 29914 | 53207855 |
Sedation | 44.34 | 9.85 | 5 | 111292 | 29670 | 53208099 |
Histoplasmosis | 44.04 | 9.85 | 34 | 111263 | 1804 | 53235965 |
Female genital tract fistula | 43.76 | 9.85 | 48 | 111249 | 4010 | 53233759 |
Foot deformity | 43.57 | 9.85 | 110 | 111187 | 18458 | 53219311 |
Anal fissure | 43.56 | 9.85 | 42 | 111255 | 3014 | 53234755 |
Impaired work ability | 43.53 | 9.85 | 93 | 111204 | 13997 | 53223772 |
Feeling abnormal | 43.49 | 9.85 | 141 | 111156 | 135160 | 53102609 |
Cytomegalovirus colitis | 43.46 | 9.85 | 35 | 111262 | 1975 | 53235794 |
Platelet count decreased | 43.46 | 9.85 | 101 | 111196 | 107998 | 53129771 |
Therapeutic product effect variable | 43.36 | 9.85 | 29 | 111268 | 1226 | 53236543 |
Central nervous system lymphoma | 43.26 | 9.85 | 31 | 111266 | 1467 | 53236302 |
Blood glucose increased | 43.07 | 9.85 | 59 | 111238 | 77302 | 53160467 |
Nicotinic acid deficiency | 42.88 | 9.85 | 12 | 111285 | 48 | 53237721 |
Immunosuppressant drug level increased | 42.81 | 9.85 | 44 | 111253 | 3411 | 53234358 |
B-cell lymphoma | 42.73 | 9.85 | 44 | 111253 | 3419 | 53234350 |
Osteonecrosis | 42.41 | 9.85 | 137 | 111160 | 26438 | 53211331 |
Cholangitis sclerosing | 42.31 | 9.85 | 28 | 111269 | 1163 | 53236606 |
Muscle injury | 42.09 | 9.85 | 6 | 111291 | 29760 | 53208009 |
Hyperkalaemia | 42.07 | 9.85 | 31 | 111266 | 54225 | 53183544 |
Intentional overdose | 41.87 | 9.85 | 47 | 111250 | 67158 | 53170611 |
Balance disorder | 41.60 | 9.85 | 55 | 111242 | 73152 | 53164617 |
Back pain | 41.49 | 9.85 | 302 | 110995 | 233945 | 53003824 |
Suicidal ideation | 41.46 | 9.85 | 39 | 111258 | 60472 | 53177297 |
Mycobacterial infection | 41.36 | 9.85 | 32 | 111265 | 1703 | 53236066 |
Papilloma viral infection | 41.21 | 9.85 | 29 | 111268 | 1333 | 53236436 |
Dehydration | 41.05 | 9.85 | 196 | 111101 | 168214 | 53069555 |
Coma | 40.97 | 9.85 | 41 | 111256 | 61742 | 53176027 |
Phospholipidosis | 40.88 | 9.85 | 12 | 111285 | 59 | 53237710 |
Pulmonary fibrosis | 40.88 | 9.85 | 127 | 111170 | 24008 | 53213761 |
Clear cell renal cell carcinoma | 40.74 | 9.85 | 27 | 111270 | 1124 | 53236645 |
Injection site swelling | 40.63 | 9.85 | 19 | 111278 | 42609 | 53195160 |
Depressed level of consciousness | 39.80 | 9.85 | 33 | 111264 | 54395 | 53183374 |
Subcutaneous abscess | 39.77 | 9.85 | 52 | 111245 | 5222 | 53232547 |
Bradycardia | 39.75 | 9.85 | 54 | 111243 | 71002 | 53166767 |
Product label confusion | 39.74 | 9.85 | 20 | 111277 | 490 | 53237279 |
Bronchiectasis | 39.59 | 9.85 | 76 | 111221 | 10596 | 53227173 |
Foetal exposure during pregnancy | 39.28 | 9.85 | 160 | 111137 | 34555 | 53203214 |
Foetal death | 38.98 | 9.85 | 70 | 111227 | 9277 | 53228492 |
Muscle fatigue | 38.92 | 9.85 | 35 | 111262 | 2298 | 53235471 |
Antiphospholipid syndrome | 38.72 | 9.85 | 31 | 111266 | 1735 | 53236034 |
Epicondylitis | 38.68 | 9.85 | 33 | 111264 | 2019 | 53235750 |
Small intestinal obstruction | 38.59 | 9.85 | 100 | 111197 | 17047 | 53220722 |
Myasthenia gravis | 38.29 | 9.85 | 44 | 111253 | 3869 | 53233900 |
Foetal growth restriction | 38.29 | 9.85 | 60 | 111237 | 7114 | 53230655 |
Nausea | 38.28 | 9.85 | 1245 | 110052 | 754846 | 52482923 |
Renal impairment | 38.17 | 9.85 | 301 | 110996 | 83017 | 53154752 |
Premature rupture of membranes | 37.71 | 9.85 | 49 | 111248 | 4891 | 53232878 |
Fungal endocarditis | 37.55 | 9.85 | 16 | 111281 | 264 | 53237505 |
Pregnancy | 37.25 | 9.85 | 147 | 111150 | 31294 | 53206475 |
Squamous cell carcinoma of skin | 37.24 | 9.85 | 51 | 111246 | 5356 | 53232413 |
Injection site erythema | 37.18 | 9.85 | 65 | 111232 | 77184 | 53160585 |
Injection site inflammation | 37.09 | 9.85 | 40 | 111257 | 3278 | 53234491 |
Hypoglycaemia | 37.06 | 9.85 | 41 | 111256 | 58972 | 53178797 |
Immunosuppression | 36.96 | 9.85 | 62 | 111235 | 7782 | 53229987 |
Red blood cell sedimentation rate abnormal | 36.87 | 9.85 | 93 | 111204 | 15596 | 53222173 |
Respiratory arrest | 36.83 | 9.85 | 12 | 111285 | 33528 | 53204241 |
Colitis | 36.79 | 9.85 | 178 | 111119 | 41374 | 53196395 |
Bone pain | 36.78 | 9.85 | 31 | 111266 | 50691 | 53187078 |
Bone marrow failure | 36.65 | 9.85 | 142 | 111155 | 29973 | 53207796 |
Disseminated cytomegaloviral infection | 36.30 | 9.85 | 14 | 111283 | 176 | 53237593 |
Full blood count decreased | 36.03 | 9.85 | 4 | 111293 | 24025 | 53213744 |
Intestinal fibrosis | 36.02 | 9.85 | 13 | 111284 | 134 | 53237635 |
Dermatomyositis | 35.91 | 9.85 | 34 | 111263 | 2385 | 53235384 |
Abdominal adhesions | 35.87 | 9.85 | 38 | 111259 | 3052 | 53234717 |
Serotonin syndrome | 35.80 | 9.85 | 6 | 111291 | 26400 | 53211369 |
Ileostomy | 35.74 | 9.85 | 25 | 111272 | 1138 | 53236631 |
Orthostatic hypotension | 35.70 | 9.85 | 9 | 111288 | 29744 | 53208025 |
Metabolic acidosis | 35.62 | 9.85 | 22 | 111275 | 42220 | 53195549 |
Chronic obstructive pulmonary disease | 35.61 | 9.85 | 45 | 111252 | 61028 | 53176741 |
Enterocutaneous fistula | 35.41 | 9.85 | 26 | 111271 | 1278 | 53236491 |
Wrong technique in product usage process | 35.24 | 9.85 | 44 | 111253 | 59988 | 53177781 |
Low birth weight baby | 35.22 | 9.85 | 54 | 111243 | 6283 | 53231486 |
Pneumonia cytomegaloviral | 35.09 | 9.85 | 32 | 111265 | 2140 | 53235629 |
Crepitations | 35.03 | 9.85 | 56 | 111241 | 6753 | 53231016 |
Nephrotic syndrome | 34.69 | 9.85 | 49 | 111248 | 5296 | 53232473 |
Inflammatory bowel disease | 34.54 | 9.85 | 41 | 111256 | 3732 | 53234037 |
Drug specific antibody present | 34.40 | 9.85 | 39 | 111258 | 3379 | 53234390 |
Secondary immunodeficiency | 34.34 | 9.85 | 24 | 111273 | 1091 | 53236678 |
Musculoskeletal stiffness | 34.29 | 9.85 | 401 | 110896 | 122967 | 53114802 |
Chorioretinopathy | 34.18 | 9.85 | 22 | 111275 | 871 | 53236898 |
Infusion related reaction | 34.10 | 9.85 | 485 | 110812 | 155472 | 53082297 |
Palmar-plantar erythrodysaesthesia syndrome | 33.95 | 9.85 | 3 | 111294 | 21603 | 53216166 |
Intentional self-injury | 33.72 | 9.85 | 6 | 111291 | 25278 | 53212491 |
Intentional product misuse | 33.64 | 9.85 | 32 | 111265 | 49360 | 53188409 |
White blood cell count decreased | 33.25 | 9.85 | 140 | 111157 | 124335 | 53113434 |
Liver transplant rejection | 33.10 | 9.85 | 26 | 111271 | 1415 | 53236354 |
Proctitis | 33.04 | 9.85 | 30 | 111267 | 1995 | 53235774 |
Nodular regenerative hyperplasia | 32.40 | 9.85 | 15 | 111282 | 304 | 53237465 |
Dyskinesia | 32.22 | 9.85 | 13 | 111284 | 31820 | 53205949 |
Plasmablastic lymphoma | 32.00 | 9.85 | 14 | 111283 | 247 | 53237522 |
Panniculitis | 31.92 | 9.85 | 58 | 111239 | 7756 | 53230013 |
Mycobacterium abscessus infection | 31.85 | 9.85 | 19 | 111278 | 656 | 53237113 |
Suicide attempt | 31.74 | 9.85 | 45 | 111252 | 58123 | 53179646 |
Renal mass | 31.63 | 9.85 | 29 | 111268 | 1953 | 53235816 |
Duodenal ulcer perforation | 31.55 | 9.85 | 17 | 111280 | 35166 | 53202603 |
Neuropathy peripheral | 31.46 | 9.85 | 110 | 111187 | 103077 | 53134692 |
Injury | 31.37 | 9.85 | 36 | 111261 | 50935 | 53186834 |
Heart transplant rejection | 31.27 | 9.85 | 17 | 111280 | 490 | 53237279 |
Irritable bowel syndrome | 31.23 | 9.85 | 27 | 111270 | 43605 | 53194164 |
Live birth | 31.03 | 9.85 | 85 | 111212 | 14974 | 53222795 |
Trichodysplasia spinulosa | 30.96 | 9.85 | 17 | 111280 | 500 | 53237269 |
Adverse reaction | 30.91 | 9.85 | 62 | 111235 | 8925 | 53228844 |
Drug withdrawal syndrome | 30.81 | 9.85 | 10 | 111287 | 28012 | 53209757 |
Headache | 30.77 | 9.85 | 869 | 110428 | 535952 | 52701817 |
Natural killer-cell leukaemia | 30.60 | 9.85 | 11 | 111286 | 112 | 53237657 |
Pyoderma gangrenosum | 30.58 | 9.85 | 35 | 111262 | 3064 | 53234705 |
Salmonellosis | 30.49 | 9.85 | 21 | 111276 | 932 | 53236837 |
Acute kidney injury | 30.38 | 9.85 | 361 | 110936 | 253507 | 52984262 |
Retinitis | 30.30 | 9.85 | 23 | 111274 | 1190 | 53236579 |
Product quality issue | 30.23 | 9.85 | 20 | 111277 | 37003 | 53200766 |
Rhegmatogenous retinal detachment | 30.16 | 9.85 | 10 | 111287 | 78 | 53237691 |
Synovitis | 30.11 | 9.85 | 351 | 110946 | 107542 | 53130227 |
Rectal abscess | 29.95 | 9.85 | 22 | 111275 | 1082 | 53236687 |
Complications of bone marrow transplant | 29.92 | 9.85 | 16 | 111281 | 446 | 53237323 |
Injection site bruising | 29.85 | 9.85 | 21 | 111276 | 37625 | 53200144 |
Bronchitis | 29.80 | 9.85 | 126 | 111171 | 111773 | 53125996 |
Blister | 29.74 | 9.85 | 76 | 111221 | 78677 | 53159092 |
Drug ineffective for unapproved indication | 29.68 | 9.85 | 103 | 111194 | 20617 | 53217152 |
Hyperhidrosis | 29.64 | 9.85 | 103 | 111194 | 96690 | 53141079 |
Jaw fracture | 29.55 | 9.85 | 32 | 111265 | 2635 | 53235134 |
Coombs positive haemolytic anaemia | 29.53 | 9.85 | 15 | 111282 | 375 | 53237394 |
Eye infection toxoplasmal | 29.44 | 9.85 | 14 | 111283 | 302 | 53237467 |
Scleroderma renal crisis | 29.36 | 9.85 | 14 | 111283 | 304 | 53237465 |
Mycobacterium avium complex infection | 29.34 | 9.85 | 33 | 111264 | 2835 | 53234934 |
Lactic acidosis | 29.25 | 9.85 | 21 | 111276 | 37232 | 53200537 |
Restlessness | 29.21 | 9.85 | 11 | 111286 | 28076 | 53209693 |
Cervical dysplasia | 29.07 | 9.85 | 34 | 111263 | 3047 | 53234722 |
Extrapulmonary tuberculosis | 28.94 | 9.85 | 14 | 111283 | 314 | 53237455 |
Varicella zoster virus infection | 28.83 | 9.85 | 31 | 111266 | 2532 | 53235237 |
Fluid retention | 28.78 | 9.85 | 43 | 111254 | 54358 | 53183411 |
Synovial cyst | 28.78 | 9.85 | 58 | 111239 | 8378 | 53229391 |
Meningitis cryptococcal | 28.71 | 9.85 | 23 | 111274 | 1288 | 53236481 |
Device dislocation | 28.58 | 9.85 | 7 | 111290 | 23590 | 53214179 |
Myositis | 28.55 | 9.85 | 58 | 111239 | 8425 | 53229344 |
Laryngeal disorder | 28.54 | 9.85 | 20 | 111277 | 913 | 53236856 |
Rectal cancer metastatic | 28.42 | 9.85 | 13 | 111284 | 256 | 53237513 |
Multiple sclerosis relapse | 28.34 | 9.85 | 31 | 111266 | 44822 | 53192947 |
Ganglioneuroma | 28.33 | 9.85 | 11 | 111286 | 141 | 53237628 |
Herpes simplex hepatitis | 28.31 | 9.85 | 14 | 111283 | 330 | 53237439 |
Neoplasm malignant | 28.18 | 9.85 | 117 | 111180 | 25484 | 53212285 |
Therapeutic reaction time decreased | 28.16 | 9.85 | 23 | 111274 | 1324 | 53236445 |
Uveitis | 27.91 | 9.85 | 62 | 111235 | 9582 | 53228187 |
Episcleritis | 27.84 | 9.85 | 19 | 111278 | 831 | 53236938 |
Antisynthetase syndrome | 27.63 | 9.85 | 9 | 111288 | 66 | 53237703 |
Folliculitis | 27.45 | 9.85 | 16 | 111281 | 31693 | 53206076 |
Hepatic fibrosis | 27.41 | 9.85 | 34 | 111263 | 3239 | 53234530 |
Aspergillus infection | 27.34 | 9.85 | 53 | 111244 | 7443 | 53230326 |
Cardiac failure | 27.20 | 9.85 | 90 | 111207 | 85754 | 53152015 |
Joint effusion | 27.15 | 9.85 | 75 | 111222 | 13277 | 53224492 |
Contraindicated product administered | 26.98 | 9.85 | 415 | 110882 | 135214 | 53102555 |
Kaposi's sarcoma | 26.89 | 9.85 | 11 | 111286 | 163 | 53237606 |
Accidental exposure to product | 26.83 | 9.85 | 8 | 111289 | 23666 | 53214103 |
Abdominal abscess | 26.81 | 9.85 | 39 | 111258 | 4331 | 53233438 |
Anogenital warts | 26.72 | 9.85 | 15 | 111282 | 461 | 53237308 |
Antinuclear antibody negative | 26.62 | 9.85 | 12 | 111285 | 228 | 53237541 |
Mental status changes | 26.53 | 9.85 | 26 | 111271 | 39545 | 53198224 |
Tractional retinal detachment | 26.51 | 9.85 | 8 | 111289 | 44 | 53237725 |
Klebsiella infection | 26.45 | 9.85 | 54 | 111243 | 7872 | 53229897 |
Abscess intestinal | 26.41 | 9.85 | 23 | 111274 | 1447 | 53236322 |
Colectomy total | 26.27 | 9.85 | 10 | 111287 | 121 | 53237648 |
Inappropriate schedule of product administration | 26.22 | 9.85 | 255 | 111042 | 74623 | 53163146 |
Thiopurine methyltransferase decreased | 26.04 | 9.85 | 13 | 111284 | 313 | 53237456 |
Congenital osteodystrophy | 25.86 | 9.85 | 7 | 111290 | 24 | 53237745 |
Aphthous ulcer | 25.79 | 9.85 | 65 | 111232 | 10893 | 53226876 |
Myocardial infarction | 25.76 | 9.85 | 113 | 111184 | 99241 | 53138528 |
Somatic delusion | 25.73 | 9.85 | 16 | 111281 | 596 | 53237173 |
Emotional distress | 25.66 | 9.85 | 18 | 111279 | 32299 | 53205470 |
Drug tolerance decreased | 25.59 | 9.85 | 51 | 111246 | 7307 | 53230462 |
Eosinophilic granulomatosis with polyangiitis | 25.45 | 9.85 | 27 | 111270 | 2172 | 53235597 |
Drug tolerance | 25.41 | 9.85 | 38 | 111259 | 4325 | 53233444 |
Bursitis infective | 25.18 | 9.85 | 21 | 111276 | 1245 | 53236524 |
Strongyloidiasis | 25.15 | 9.85 | 19 | 111278 | 976 | 53236793 |
Glomerulosclerosis | 24.99 | 9.85 | 13 | 111284 | 342 | 53237427 |
Encephalopathy | 24.89 | 9.85 | 24 | 111273 | 36784 | 53200985 |
Oedema peripheral | 24.83 | 9.85 | 232 | 111065 | 170555 | 53067214 |
Pneumonia aspiration | 24.82 | 9.85 | 21 | 111276 | 34280 | 53203489 |
Asthma | 24.72 | 9.85 | 130 | 111167 | 108842 | 53128927 |
Ileectomy | 24.70 | 9.85 | 10 | 111287 | 144 | 53237625 |
Helicobacter infection | 24.69 | 9.85 | 27 | 111270 | 39042 | 53198727 |
Abscess rupture | 24.65 | 9.85 | 12 | 111285 | 273 | 53237496 |
Intestinal mucosal hypertrophy | 24.45 | 9.85 | 11 | 111286 | 208 | 53237561 |
Wrist deformity | 24.38 | 9.85 | 24 | 111273 | 1767 | 53236002 |
Meningoencephalitis viral | 24.09 | 9.85 | 13 | 111284 | 369 | 53237400 |
Myelosuppression | 24.08 | 9.85 | 70 | 111227 | 12758 | 53225011 |
Anal cancer | 24.01 | 9.85 | 14 | 111283 | 463 | 53237306 |
Rectal discharge | 24.01 | 9.85 | 14 | 111283 | 463 | 53237306 |
Cardiac disorder | 24.00 | 9.85 | 38 | 111259 | 46928 | 53190841 |
Tuberculosis of central nervous system | 24.00 | 9.85 | 13 | 111284 | 372 | 53237397 |
Varicella | 23.95 | 9.85 | 24 | 111273 | 1805 | 53235964 |
Intestinal anastomosis | 23.88 | 9.85 | 12 | 111285 | 293 | 53237476 |
Urinary retention | 23.76 | 9.85 | 15 | 111282 | 28451 | 53209318 |
Hypomagnesaemia | 23.73 | 9.85 | 11 | 111286 | 24800 | 53212969 |
Renal transplant failure | 23.72 | 9.85 | 16 | 111281 | 686 | 53237083 |
Dysgeusia | 23.63 | 9.85 | 33 | 111264 | 42898 | 53194871 |
Infectious mononucleosis | 23.63 | 9.85 | 23 | 111274 | 1670 | 53236099 |
Vomiting | 23.55 | 9.85 | 825 | 110472 | 496314 | 52741455 |
Unresponsive to stimuli | 23.54 | 9.85 | 21 | 111276 | 33405 | 53204364 |
Impaired healing | 23.45 | 9.85 | 63 | 111234 | 64142 | 53173627 |
HELLP syndrome | 23.27 | 9.85 | 18 | 111279 | 958 | 53236811 |
Serum sickness | 23.10 | 9.85 | 28 | 111269 | 2605 | 53235164 |
External auditory canal atresia | 22.93 | 9.85 | 8 | 111289 | 74 | 53237695 |
Gastrointestinal stoma output abnormal | 22.69 | 9.85 | 7 | 111290 | 42 | 53237727 |
Disturbance in attention | 22.58 | 9.85 | 23 | 111274 | 34360 | 53203409 |
Aplasia pure red cell | 22.56 | 9.85 | 37 | 111260 | 4559 | 53233210 |
Small intestinal stenosis | 22.55 | 9.85 | 14 | 111283 | 520 | 53237249 |
Oesophageal squamous cell carcinoma | 22.53 | 9.85 | 9 | 111288 | 125 | 53237644 |
Proctalgia | 22.52 | 9.85 | 40 | 111257 | 5256 | 53232513 |
Atypical haemolytic uraemic syndrome | 22.38 | 9.85 | 14 | 111283 | 527 | 53237242 |
Sopor | 22.36 | 9.85 | 8 | 111289 | 21076 | 53216693 |
Corynebacterium infection | 22.35 | 9.85 | 13 | 111284 | 428 | 53237341 |
Flank pain | 22.19 | 9.85 | 72 | 111225 | 13924 | 53223845 |
Porokeratosis | 22.14 | 9.85 | 9 | 111288 | 131 | 53237638 |
Sleep disorder | 22.08 | 9.85 | 57 | 111240 | 58813 | 53178956 |
Appendicitis | 22.05 | 9.85 | 46 | 111251 | 6808 | 53230961 |
Conjunctivitis | 22.05 | 9.85 | 82 | 111215 | 16975 | 53220794 |
Abdominal pain upper | 22.04 | 9.85 | 231 | 111066 | 166060 | 53071709 |
Disorientation | 21.92 | 9.85 | 30 | 111267 | 39329 | 53198440 |
Small intestine carcinoma | 21.76 | 9.85 | 12 | 111285 | 356 | 53237413 |
Hydrops foetalis | 21.70 | 9.85 | 12 | 111285 | 358 | 53237411 |
Delirium | 21.67 | 9.85 | 33 | 111264 | 41396 | 53196373 |
Gastrointestinal haemorrhage | 21.66 | 9.85 | 90 | 111207 | 80240 | 53157529 |
Renal tubular atrophy | 21.64 | 9.85 | 14 | 111283 | 559 | 53237210 |
Central nervous system vasculitis | 21.60 | 9.85 | 17 | 111280 | 928 | 53236841 |
Lipase increased | 21.42 | 9.85 | 55 | 111242 | 9323 | 53228446 |
Accidental overdose | 21.37 | 9.85 | 9 | 111288 | 21470 | 53216299 |
Herpes simplex reactivation | 21.34 | 9.85 | 12 | 111285 | 370 | 53237399 |
Lymphadenopathy | 21.24 | 9.85 | 139 | 111158 | 36116 | 53201653 |
Skin lesion | 21.21 | 9.85 | 117 | 111180 | 28612 | 53209157 |
Therapeutic response shortened | 21.21 | 9.85 | 46 | 111251 | 6993 | 53230776 |
Primary biliary cholangitis | 21.15 | 9.85 | 19 | 111278 | 1246 | 53236523 |
Anorectal disorder | 21.11 | 9.85 | 21 | 111276 | 1566 | 53236203 |
Brain abscess | 21.00 | 9.85 | 23 | 111274 | 1918 | 53235851 |
Medication error | 20.98 | 9.85 | 27 | 111270 | 36338 | 53201431 |
Spinal cord infection | 20.93 | 9.85 | 14 | 111283 | 592 | 53237177 |
Dysplasia | 20.93 | 9.85 | 15 | 111282 | 710 | 53237059 |
Fistula of small intestine | 20.79 | 9.85 | 11 | 111286 | 300 | 53237469 |
Lupus myocarditis | 20.74 | 9.85 | 7 | 111290 | 58 | 53237711 |
Cholesteatoma | 20.72 | 9.85 | 9 | 111288 | 156 | 53237613 |
Rectal stenosis | 20.72 | 9.85 | 9 | 111288 | 156 | 53237613 |
Peripheral swelling | 20.65 | 9.85 | 304 | 110993 | 205804 | 53031965 |
Thrombotic microangiopathy | 20.55 | 9.85 | 54 | 111243 | 9283 | 53228486 |
Sebaceous carcinoma | 20.53 | 9.85 | 6 | 111291 | 29 | 53237740 |
International normalised ratio increased | 20.52 | 9.85 | 43 | 111254 | 47718 | 53190051 |
T-cell lymphoma | 20.45 | 9.85 | 15 | 111282 | 736 | 53237033 |
Gestational diabetes | 20.31 | 9.85 | 49 | 111248 | 7990 | 53229779 |
Skin ulcer | 20.27 | 9.85 | 137 | 111160 | 35982 | 53201787 |
Femur fracture | 20.26 | 9.85 | 32 | 111265 | 39553 | 53198216 |
Blood calcium decreased | 20.17 | 9.85 | 8 | 111289 | 19786 | 53217983 |
Antineutrophil cytoplasmic antibody increased | 20.14 | 9.85 | 7 | 111290 | 64 | 53237705 |
Ileostomy closure | 20.10 | 9.85 | 8 | 111289 | 110 | 53237659 |
Hepatitis | 19.89 | 9.85 | 130 | 111167 | 33764 | 53204005 |
Transaminases increased | 19.82 | 9.85 | 119 | 111178 | 30013 | 53207756 |
Epistaxis | 19.78 | 9.85 | 75 | 111222 | 68635 | 53169134 |
Cytomegalovirus hepatitis | 19.69 | 9.85 | 11 | 111286 | 335 | 53237434 |
Anaplastic large cell lymphoma T- and null-cell types | 19.49 | 9.85 | 7 | 111290 | 71 | 53237698 |
Nasopharyngitis | 19.48 | 9.85 | 283 | 111014 | 192012 | 53045757 |
Gastrointestinal fistula | 19.44 | 9.85 | 12 | 111285 | 441 | 53237328 |
Candida infection | 19.39 | 9.85 | 104 | 111193 | 25169 | 53212600 |
Cerebral toxoplasmosis | 19.36 | 9.85 | 15 | 111282 | 800 | 53236969 |
Cough | 19.29 | 9.85 | 399 | 110898 | 256494 | 52981275 |
Hepatosplenomegaly | 19.26 | 9.85 | 25 | 111272 | 2493 | 53235276 |
Muscle spasms | 19.21 | 9.85 | 184 | 111113 | 134611 | 53103158 |
Malignant polyp | 19.10 | 9.85 | 9 | 111288 | 190 | 53237579 |
Poisoning | 19.10 | 9.85 | 3 | 111294 | 13847 | 53223922 |
Pulmonary embolism | 19.07 | 9.85 | 150 | 111147 | 114292 | 53123477 |
Paraesthesia | 19.06 | 9.85 | 172 | 111125 | 127343 | 53110426 |
Hyperadrenocorticism | 19.03 | 9.85 | 11 | 111286 | 358 | 53237411 |
COVID-19 | 18.99 | 9.85 | 137 | 111160 | 36751 | 53201018 |
Trichostasis spinulosa | 18.97 | 9.85 | 5 | 111292 | 15 | 53237754 |
Abnormal faeces | 18.96 | 9.85 | 34 | 111263 | 4500 | 53233269 |
Transient hypogammaglobulinaemia of infancy | 18.78 | 9.85 | 6 | 111291 | 41 | 53237728 |
Hypoaesthesia | 18.76 | 9.85 | 182 | 111115 | 132813 | 53104956 |
Congenital syphilitic osteochondritis | 18.73 | 9.85 | 5 | 111292 | 16 | 53237753 |
Sleep apnoea syndrome | 18.72 | 9.85 | 16 | 111281 | 25986 | 53211783 |
Cognitive disorder | 18.67 | 9.85 | 41 | 111256 | 44737 | 53193032 |
Device issue | 18.65 | 9.85 | 11 | 111286 | 21647 | 53216122 |
Rectal haemorrhage | 18.52 | 9.85 | 149 | 111148 | 41332 | 53196437 |
Adverse drug reaction | 18.46 | 9.85 | 182 | 111115 | 53443 | 53184326 |
Hip fracture | 18.44 | 9.85 | 19 | 111278 | 28238 | 53209531 |
Weber tuning fork test abnormal | 18.44 | 9.85 | 7 | 111290 | 84 | 53237685 |
Malignant melanoma | 18.44 | 9.85 | 57 | 111240 | 10745 | 53227024 |
Chronic hepatitis | 18.44 | 9.85 | 15 | 111282 | 859 | 53236910 |
Underdose | 18.43 | 9.85 | 11 | 111286 | 21511 | 53216258 |
Meningitis listeria | 18.42 | 9.85 | 12 | 111285 | 485 | 53237284 |
Nightmare | 18.38 | 9.85 | 7 | 111290 | 17744 | 53220025 |
Throat cancer | 18.25 | 9.85 | 12 | 111285 | 493 | 53237276 |
Body temperature fluctuation | 18.22 | 9.85 | 22 | 111275 | 2039 | 53235730 |
Fear | 18.19 | 9.85 | 6 | 111291 | 16635 | 53221134 |
Lung abscess | 18.17 | 9.85 | 20 | 111277 | 1677 | 53236092 |
Actinic keratosis | 18.17 | 9.85 | 24 | 111273 | 2434 | 53235335 |
Transient ischaemic attack | 18.17 | 9.85 | 29 | 111268 | 35696 | 53202073 |
Therapy interrupted | 18.01 | 9.85 | 9 | 111288 | 19427 | 53218342 |
Lethargy | 17.98 | 9.85 | 55 | 111242 | 53705 | 53184064 |
Pseudoxanthoma elasticum-like syndrome | 17.93 | 9.85 | 4 | 111293 | 4 | 53237765 |
Mitochondrial neurogastrointestinal encephalopathy | 17.93 | 9.85 | 4 | 111293 | 4 | 53237765 |
Injection site pain | 17.81 | 9.85 | 151 | 111146 | 113240 | 53124529 |
Withdrawal syndrome | 17.79 | 9.85 | 9 | 111288 | 19292 | 53218477 |
Abortion missed | 17.75 | 9.85 | 20 | 111277 | 1721 | 53236048 |
Proctectomy | 17.75 | 9.85 | 6 | 111291 | 50 | 53237719 |
Hypocalcaemia | 17.75 | 9.85 | 21 | 111276 | 29316 | 53208453 |
Drug level abnormal | 17.73 | 9.85 | 7 | 111290 | 94 | 53237675 |
Pneumocystis jirovecii infection | 17.69 | 9.85 | 18 | 111279 | 1379 | 53236390 |
Anorectal stenosis | 17.67 | 9.85 | 5 | 111292 | 21 | 53237748 |
Arthritis enteropathic | 17.61 | 9.85 | 9 | 111288 | 228 | 53237541 |
Bronchomalacia | 17.61 | 9.85 | 9 | 111288 | 228 | 53237541 |
Abnormal behaviour | 17.60 | 9.85 | 12 | 111285 | 21854 | 53215915 |
Anal ulcer | 17.58 | 9.85 | 12 | 111285 | 525 | 53237244 |
Polymyositis | 17.54 | 9.85 | 20 | 111277 | 1744 | 53236025 |
Tenosynovitis | 17.48 | 9.85 | 53 | 111244 | 9886 | 53227883 |
Blood glucose decreased | 17.47 | 9.85 | 10 | 111287 | 20006 | 53217763 |
Stress at work | 17.40 | 9.85 | 16 | 111281 | 1081 | 53236688 |
Dry skin | 17.40 | 9.85 | 44 | 111253 | 45716 | 53192053 |
Oral lichen planus | 17.32 | 9.85 | 12 | 111285 | 538 | 53237231 |
Gastrointestinal wall thickening | 17.29 | 9.85 | 16 | 111281 | 1090 | 53236679 |
Neutropenia | 17.29 | 9.85 | 231 | 111066 | 158954 | 53078815 |
Pulmonary oedema | 17.24 | 9.85 | 56 | 111241 | 53667 | 53184102 |
Intestinal polyp | 17.18 | 9.85 | 17 | 111280 | 1259 | 53236510 |
Retinal injury | 17.09 | 9.85 | 9 | 111288 | 243 | 53237526 |
Enterostomy | 17.06 | 9.85 | 8 | 111289 | 167 | 53237602 |
Inappropriate antidiuretic hormone secretion | 17.04 | 9.85 | 5 | 111292 | 14946 | 53222823 |
Microsporidia infection | 16.89 | 9.85 | 9 | 111288 | 249 | 53237520 |
Polyhydramnios | 16.87 | 9.85 | 22 | 111275 | 2203 | 53235566 |
Microscopic polyangiitis | 16.72 | 9.85 | 8 | 111289 | 175 | 53237594 |
Dementia | 16.69 | 9.85 | 7 | 111290 | 16743 | 53221026 |
Cytomegalovirus mucocutaneous ulcer | 16.67 | 9.85 | 4 | 111293 | 7 | 53237762 |
Weight decreased | 16.65 | 9.85 | 623 | 110674 | 234325 | 53003444 |
Microtia | 16.64 | 9.85 | 10 | 111287 | 350 | 53237419 |
Palatal ulcer | 16.61 | 9.85 | 6 | 111291 | 62 | 53237707 |
Gingival hypertrophy | 16.51 | 9.85 | 18 | 111279 | 1493 | 53236276 |
Anterograde amnesia | 16.51 | 9.85 | 11 | 111286 | 462 | 53237307 |
Defaecation urgency | 16.47 | 9.85 | 26 | 111271 | 3102 | 53234667 |
Metastases to bone | 16.38 | 9.85 | 10 | 111287 | 19318 | 53218451 |
Pain in extremity | 16.38 | 9.85 | 461 | 110836 | 284589 | 52953180 |
B-cell unclassifiable lymphoma high grade | 16.32 | 9.85 | 4 | 111293 | 8 | 53237761 |
Vision blurred | 16.29 | 9.85 | 108 | 111189 | 85496 | 53152273 |
Retinal toxicity | 16.22 | 9.85 | 16 | 111281 | 1181 | 53236588 |
Coronary artery disease | 16.21 | 9.85 | 28 | 111269 | 33409 | 53204360 |
American trypanosomiasis | 16.20 | 9.85 | 6 | 111291 | 67 | 53237702 |
Pruritus | 16.18 | 9.85 | 478 | 110819 | 293354 | 52944415 |
Head injury | 16.16 | 9.85 | 18 | 111279 | 25815 | 53211954 |
Pulmonary necrosis | 16.13 | 9.85 | 7 | 111290 | 121 | 53237648 |
Aggression | 16.13 | 9.85 | 15 | 111282 | 23388 | 53214381 |
Deep vein thrombosis | 16.09 | 9.85 | 104 | 111193 | 82809 | 53154960 |
Cleft lip and palate | 16.07 | 9.85 | 10 | 111287 | 373 | 53237396 |
Squamous cell carcinoma of the tongue | 16.07 | 9.85 | 10 | 111287 | 373 | 53237396 |
Gait disturbance | 16.00 | 9.85 | 234 | 111063 | 158608 | 53079161 |
Acute myocardial infarction | 15.95 | 9.85 | 28 | 111269 | 33207 | 53204562 |
Diabetic ketoacidosis | 15.93 | 9.85 | 11 | 111286 | 19904 | 53217865 |
Gastrointestinal motility disorder | 15.92 | 9.85 | 33 | 111264 | 4863 | 53232906 |
Irritability | 15.86 | 9.85 | 25 | 111272 | 30928 | 53206841 |
Hirsutism | 15.83 | 9.85 | 15 | 111282 | 1053 | 53236716 |
Anaplastic large-cell lymphoma | 15.82 | 9.85 | 7 | 111290 | 127 | 53237642 |
Metastases to central nervous system | 15.78 | 9.85 | 3 | 111294 | 12054 | 53225715 |
Listeria sepsis | 15.77 | 9.85 | 12 | 111285 | 623 | 53237146 |
Pleural effusion | 15.75 | 9.85 | 114 | 111183 | 88465 | 53149304 |
Nocardiosis | 15.62 | 9.85 | 20 | 111277 | 1967 | 53235802 |
Hyperthyroidism | 15.60 | 9.85 | 4 | 111293 | 13069 | 53224700 |
Torsade de pointes | 15.48 | 9.85 | 4 | 111293 | 13001 | 53224768 |
Anal squamous cell carcinoma | 15.47 | 9.85 | 10 | 111287 | 399 | 53237370 |
Acne conglobata | 15.43 | 9.85 | 4 | 111293 | 11 | 53237758 |
Oral pain | 15.41 | 9.85 | 20 | 111277 | 26817 | 53210952 |
Eye ulcer | 15.32 | 9.85 | 9 | 111288 | 302 | 53237467 |
Myelitis | 15.31 | 9.85 | 16 | 111281 | 1265 | 53236504 |
Anovulatory cycle | 15.29 | 9.85 | 7 | 111290 | 138 | 53237631 |
Polyomavirus-associated nephropathy | 15.23 | 9.85 | 18 | 111279 | 1631 | 53236138 |
Opportunistic infection | 15.19 | 9.85 | 19 | 111278 | 1825 | 53235944 |
DNA antibody | 15.19 | 9.85 | 5 | 111292 | 38 | 53237731 |
Superinfection | 15.18 | 9.85 | 21 | 111276 | 2226 | 53235543 |
Symptom masked | 15.04 | 9.85 | 12 | 111285 | 668 | 53237101 |
Cutaneous leishmaniasis | 15.04 | 9.85 | 6 | 111291 | 83 | 53237686 |
Haematoma | 14.94 | 9.85 | 30 | 111267 | 33814 | 53203955 |
Gastrointestinal scarring | 14.93 | 9.85 | 8 | 111289 | 224 | 53237545 |
Lymphoma | 14.92 | 9.85 | 52 | 111245 | 10430 | 53227339 |
Tuberous sclerosis complex | 14.91 | 9.85 | 6 | 111291 | 85 | 53237684 |
Coloboma | 14.91 | 9.85 | 6 | 111291 | 85 | 53237684 |
Herpes virus infection | 14.90 | 9.85 | 33 | 111264 | 5090 | 53232679 |
Nervousness | 14.87 | 9.85 | 25 | 111272 | 30153 | 53207616 |
Patent ductus arteriosus | 14.87 | 9.85 | 29 | 111268 | 4089 | 53233680 |
Gastroenteritis norovirus | 14.81 | 9.85 | 18 | 111279 | 1679 | 53236090 |
Anal stenosis | 14.80 | 9.85 | 9 | 111288 | 322 | 53237447 |
Obstructive airways disorder | 14.80 | 9.85 | 9 | 111288 | 17420 | 53220349 |
Fistula discharge | 14.79 | 9.85 | 14 | 111283 | 982 | 53236787 |
Steatorrhoea | 14.78 | 9.85 | 10 | 111287 | 431 | 53237338 |
Urinary incontinence | 14.76 | 9.85 | 26 | 111271 | 30795 | 53206974 |
Granuloma skin | 14.76 | 9.85 | 33 | 111264 | 5121 | 53232648 |
Legionella infection | 14.72 | 9.85 | 10 | 111287 | 434 | 53237335 |
Fluid overload | 14.72 | 9.85 | 22 | 111275 | 27809 | 53209960 |
Dysphonia | 14.68 | 9.85 | 42 | 111255 | 41896 | 53195873 |
Intestinal operation | 14.68 | 9.85 | 10 | 111287 | 436 | 53237333 |
Speech disorder | 14.64 | 9.85 | 38 | 111259 | 39143 | 53198626 |
Epstein-Barr virus associated lymphoma | 14.64 | 9.85 | 10 | 111287 | 438 | 53237331 |
Memory impairment | 14.63 | 9.85 | 110 | 111187 | 84647 | 53153122 |
Product administration error | 14.60 | 9.85 | 14 | 111283 | 21517 | 53216252 |
Myopathy | 14.60 | 9.85 | 49 | 111248 | 9643 | 53228126 |
Pelvic abscess | 14.57 | 9.85 | 17 | 111280 | 1519 | 53236250 |
Intestinal anastomosis complication | 14.52 | 9.85 | 8 | 111289 | 237 | 53237532 |
Bowel movement irregularity | 14.52 | 9.85 | 29 | 111268 | 4162 | 53233607 |
Takayasu's arteritis | 14.50 | 9.85 | 4 | 111293 | 15 | 53237754 |
Lung infiltration | 14.48 | 9.85 | 65 | 111232 | 14642 | 53223127 |
Congenital bowing of long bones | 14.48 | 9.85 | 6 | 111291 | 92 | 53237677 |
Melaena | 14.48 | 9.85 | 24 | 111273 | 29105 | 53208664 |
Food intolerance | 14.42 | 9.85 | 22 | 111275 | 2548 | 53235221 |
Tonsillar hypertrophy | 14.41 | 9.85 | 13 | 111284 | 857 | 53236912 |
Blood parathyroid hormone decreased | 14.37 | 9.85 | 37 | 111260 | 6281 | 53231488 |
Mucous stools | 14.37 | 9.85 | 24 | 111273 | 3002 | 53234767 |
Foetal exposure during delivery | 14.36 | 9.85 | 5 | 111292 | 46 | 53237723 |
Tonsillitis | 14.33 | 9.85 | 33 | 111264 | 5223 | 53232546 |
Ureteral neoplasm | 14.29 | 9.85 | 4 | 111293 | 16 | 53237753 |
Lymphocytopenia neonatal | 14.29 | 9.85 | 4 | 111293 | 16 | 53237753 |
Threatened labour | 14.25 | 9.85 | 13 | 111284 | 870 | 53236899 |
Mucormycosis | 14.23 | 9.85 | 22 | 111275 | 2578 | 53235191 |
Pulmonary congestion | 14.20 | 9.85 | 8 | 111289 | 16148 | 53221621 |
Infective pulmonary exacerbation of cystic fibrosis | 14.13 | 9.85 | 3 | 111294 | 11153 | 53226616 |
Failed induction of labour | 14.13 | 9.85 | 9 | 111288 | 350 | 53237419 |
Complications of transplanted kidney | 14.10 | 9.85 | 21 | 111276 | 2382 | 53235387 |
Pollakiuria | 14.08 | 9.85 | 20 | 111277 | 25819 | 53211950 |
Blood potassium increased | 14.08 | 9.85 | 10 | 111287 | 17831 | 53219938 |
Endocarditis noninfective | 14.08 | 9.85 | 5 | 111292 | 49 | 53237720 |
Muscle spasticity | 14.08 | 9.85 | 10 | 111287 | 17828 | 53219941 |
Upper respiratory tract irritation | 13.99 | 9.85 | 5 | 111292 | 50 | 53237719 |
Eye infection fungal | 13.97 | 9.85 | 6 | 111291 | 101 | 53237668 |
Pericarditis | 13.96 | 9.85 | 78 | 111219 | 64328 | 53173441 |
Injection site warmth | 13.93 | 9.85 | 6 | 111291 | 14122 | 53223647 |
Sepsis neonatal | 13.88 | 9.85 | 10 | 111287 | 477 | 53237292 |
Complex regional pain syndrome | 13.87 | 9.85 | 20 | 111277 | 2203 | 53235566 |
Neutrophilic dermatosis | 13.81 | 9.85 | 6 | 111291 | 104 | 53237665 |
Anastomotic stenosis | 13.76 | 9.85 | 8 | 111289 | 263 | 53237506 |
Acute febrile neutrophilic dermatosis | 13.76 | 9.85 | 23 | 111274 | 2878 | 53234891 |
Hepatitis E | 13.71 | 9.85 | 15 | 111282 | 1249 | 53236520 |
Post procedural diarrhoea | 13.71 | 9.85 | 7 | 111290 | 177 | 53237592 |
Cytomegalovirus chorioretinitis | 13.60 | 9.85 | 17 | 111280 | 1632 | 53236137 |
Migraine | 13.58 | 9.85 | 105 | 111192 | 80312 | 53157457 |
Anaemia | 13.57 | 9.85 | 457 | 110840 | 276261 | 52961508 |
Muscle rigidity | 13.56 | 9.85 | 3 | 111294 | 10838 | 53226931 |
Hepatitis viral | 13.49 | 9.85 | 10 | 111287 | 499 | 53237270 |
Abnormal palmar/plantar creases | 13.48 | 9.85 | 5 | 111292 | 56 | 53237713 |
Fibroadenoma of breast | 13.47 | 9.85 | 9 | 111288 | 380 | 53237389 |
Upper gastrointestinal haemorrhage | 13.46 | 9.85 | 10 | 111287 | 17420 | 53220349 |
Transplant dysfunction | 13.46 | 9.85 | 31 | 111266 | 4907 | 53232862 |
Congenital toxoplasmosis | 13.45 | 9.85 | 3 | 111294 | 3 | 53237766 |
Mucosal inflammation | 13.45 | 9.85 | 45 | 111252 | 42739 | 53195030 |
Hyperglycaemia | 13.41 | 9.85 | 41 | 111256 | 40043 | 53197726 |
Pyometra | 13.41 | 9.85 | 6 | 111291 | 112 | 53237657 |
Acute respiratory distress syndrome | 13.39 | 9.85 | 89 | 111208 | 23243 | 53214526 |
Kidney fibrosis | 13.39 | 9.85 | 17 | 111280 | 1658 | 53236111 |
Pseudomonas infection | 13.37 | 9.85 | 50 | 111247 | 10378 | 53227391 |
Epidermodysplasia verruciformis | 13.33 | 9.85 | 5 | 111292 | 58 | 53237711 |
Laryngeal stenosis | 13.27 | 9.85 | 12 | 111285 | 794 | 53236975 |
Creatinine renal clearance decreased | 13.22 | 9.85 | 3 | 111294 | 10648 | 53227121 |
Sinus bradycardia | 13.17 | 9.85 | 7 | 111290 | 14594 | 53223175 |
Atypical mycobacterial infection | 13.13 | 9.85 | 13 | 111284 | 964 | 53236805 |
Rheumatoid lung | 13.11 | 9.85 | 20 | 111277 | 2317 | 53235452 |
Ocular toxicity | 13.09 | 9.85 | 10 | 111287 | 522 | 53237247 |
Conjunctivitis allergic | 13.08 | 9.85 | 12 | 111285 | 809 | 53236960 |
Device breakage | 13.06 | 9.85 | 3 | 111294 | 10564 | 53227205 |
Staphylococcal sepsis | 13.04 | 9.85 | 41 | 111256 | 7799 | 53229970 |
Salmonella bacteraemia | 13.03 | 9.85 | 6 | 111291 | 120 | 53237649 |
Lung disorder | 13.01 | 9.85 | 155 | 111142 | 47724 | 53190045 |
Exercise tolerance increased | 12.96 | 9.85 | 4 | 111293 | 24 | 53237745 |
Colostomy | 12.96 | 9.85 | 11 | 111286 | 668 | 53237101 |
Disease risk factor | 12.95 | 9.85 | 5 | 111292 | 63 | 53237706 |
Depressed mood | 12.95 | 9.85 | 37 | 111260 | 36927 | 53200842 |
Staphylococcal skin infection | 12.94 | 9.85 | 12 | 111285 | 820 | 53236949 |
Therapy non-responder | 12.90 | 9.85 | 158 | 111139 | 48962 | 53188807 |
Rheumatic disorder | 12.89 | 9.85 | 16 | 111281 | 1525 | 53236244 |
Anaemia macrocytic | 12.87 | 9.85 | 22 | 111275 | 2804 | 53234965 |
Bulimia nervosa | 12.85 | 9.85 | 10 | 111287 | 537 | 53237232 |
Obliterative bronchiolitis | 12.84 | 9.85 | 18 | 111279 | 1932 | 53235837 |
Anastomotic complication | 12.81 | 9.85 | 6 | 111291 | 125 | 53237644 |
Necrotising retinitis | 12.77 | 9.85 | 8 | 111289 | 302 | 53237467 |
Myasthenia gravis crisis | 12.73 | 9.85 | 9 | 111288 | 417 | 53237352 |
Ventricular tachycardia | 12.70 | 9.85 | 11 | 111286 | 17751 | 53220018 |
Placental necrosis | 12.69 | 9.85 | 4 | 111293 | 26 | 53237743 |
Fasting | 12.69 | 9.85 | 4 | 111293 | 26 | 53237743 |
Anger | 12.64 | 9.85 | 5 | 111292 | 12385 | 53225384 |
Sinusitis | 12.58 | 9.85 | 262 | 111035 | 168302 | 53069467 |
Carcinoid tumour pulmonary | 12.58 | 9.85 | 9 | 111288 | 425 | 53237344 |
Lacrimal haemorrhage | 12.56 | 9.85 | 4 | 111293 | 27 | 53237742 |
Photophobia | 12.53 | 9.85 | 67 | 111230 | 16191 | 53221578 |
Drug specific antibody | 12.52 | 9.85 | 16 | 111281 | 1571 | 53236198 |
Enterococcal sepsis | 12.52 | 9.85 | 15 | 111282 | 1379 | 53236390 |
Hypophagia | 12.49 | 9.85 | 29 | 111268 | 31033 | 53206736 |
Occult blood | 12.47 | 9.85 | 14 | 111283 | 1200 | 53236569 |
Lymphocele | 12.45 | 9.85 | 12 | 111285 | 861 | 53236908 |
Stress | 12.44 | 9.85 | 69 | 111228 | 57015 | 53180754 |
Muir-Torre syndrome | 12.44 | 9.85 | 4 | 111293 | 28 | 53237741 |
Enteritis | 12.44 | 9.85 | 39 | 111258 | 7407 | 53230362 |
Encephalitis cytomegalovirus | 12.42 | 9.85 | 10 | 111287 | 564 | 53237205 |
Throat irritation | 12.40 | 9.85 | 30 | 111267 | 31651 | 53206118 |
Tenderness | 12.39 | 9.85 | 77 | 111220 | 19653 | 53218116 |
Type 2 diabetes mellitus | 12.39 | 9.85 | 30 | 111267 | 31640 | 53206129 |
Meningitis aseptic | 12.34 | 9.85 | 28 | 111269 | 4387 | 53233382 |
Varicella zoster pneumonia | 12.32 | 9.85 | 4 | 111293 | 29 | 53237740 |
Product storage error | 12.28 | 9.85 | 6 | 111291 | 13124 | 53224645 |
Necrosis | 12.28 | 9.85 | 31 | 111266 | 5200 | 53232569 |
Maternal exposure during breast feeding | 12.27 | 9.85 | 24 | 111273 | 3393 | 53234376 |
Therapy cessation | 12.23 | 9.85 | 25 | 111272 | 28000 | 53209769 |
Ejection fraction decreased | 12.23 | 9.85 | 14 | 111283 | 19834 | 53217935 |
Injection site pruritus | 12.23 | 9.85 | 45 | 111252 | 41544 | 53196225 |
Seronegative arthritis | 12.17 | 9.85 | 18 | 111279 | 2029 | 53235740 |
Sleep disorder due to general medical condition, insomnia type | 12.16 | 9.85 | 20 | 111277 | 24329 | 53213440 |
JC virus infection | 12.16 | 9.85 | 17 | 111280 | 1820 | 53235949 |
DNA antibody positive | 12.09 | 9.85 | 8 | 111289 | 332 | 53237437 |
Infective tenosynovitis | 12.02 | 9.85 | 7 | 111290 | 231 | 53237538 |
Hot flush | 12.00 | 9.85 | 54 | 111243 | 47106 | 53190663 |
Delusion | 12.00 | 9.85 | 5 | 111292 | 12004 | 53225765 |
Bacillary angiomatosis | 11.99 | 9.85 | 5 | 111292 | 78 | 53237691 |
Electrolyte imbalance | 11.99 | 9.85 | 13 | 111284 | 18871 | 53218898 |
Gastrointestinal stoma complication | 11.98 | 9.85 | 16 | 111281 | 1640 | 53236129 |
Cranial sutures widening | 11.98 | 9.85 | 4 | 111293 | 32 | 53237737 |
Skin cancer | 11.98 | 9.85 | 46 | 111251 | 9668 | 53228101 |
Neoplasm skin | 11.96 | 9.85 | 13 | 111284 | 1075 | 53236694 |
Amniotic cavity infection | 11.96 | 9.85 | 14 | 111283 | 1256 | 53236513 |
Tuberculosis of eye | 11.93 | 9.85 | 3 | 111294 | 7 | 53237762 |
Cheilitis granulomatosa | 11.93 | 9.85 | 3 | 111294 | 7 | 53237762 |
Complications of transplanted lung | 11.91 | 9.85 | 7 | 111290 | 235 | 53237534 |
Central nervous system necrosis | 11.89 | 9.85 | 6 | 111291 | 148 | 53237621 |
Glomerulonephritis | 11.87 | 9.85 | 16 | 111281 | 1655 | 53236114 |
Dysarthria | 11.86 | 9.85 | 44 | 111253 | 40524 | 53197245 |
Heart rate irregular | 11.85 | 9.85 | 78 | 111219 | 20306 | 53217463 |
Large intestinal ulcer | 11.83 | 9.85 | 23 | 111274 | 3236 | 53234533 |
Systemic lupus erythematosus | 11.81 | 9.85 | 344 | 110953 | 125070 | 53112699 |
Immune-mediated myositis | 11.78 | 9.85 | 13 | 111284 | 1093 | 53236676 |
Abdominal pain lower | 11.78 | 9.85 | 87 | 111210 | 23506 | 53214263 |
Rash maculo-papular | 11.78 | 9.85 | 28 | 111269 | 29721 | 53208048 |
Butterfly rash | 11.77 | 9.85 | 13 | 111284 | 1094 | 53236675 |
Gastritis haemorrhagic | 11.77 | 9.85 | 15 | 111282 | 1469 | 53236300 |
Thrombocytopenia | 11.77 | 9.85 | 211 | 111086 | 138516 | 53099253 |
Ileal ulcer | 11.73 | 9.85 | 9 | 111288 | 473 | 53237296 |
Lacrimation increased | 11.73 | 9.85 | 12 | 111285 | 17891 | 53219878 |
Ear pain | 11.69 | 9.85 | 28 | 111269 | 29645 | 53208124 |
Strabismus congenital | 11.66 | 9.85 | 4 | 111293 | 35 | 53237734 |
Muscular dystrophy | 11.66 | 9.85 | 4 | 111293 | 35 | 53237734 |
Injection site mass | 11.64 | 9.85 | 10 | 111287 | 16204 | 53221565 |
Adjustment disorder with depressed mood | 11.64 | 9.85 | 20 | 111277 | 2560 | 53235209 |
Pyoderma | 11.62 | 9.85 | 7 | 111290 | 246 | 53237523 |
Hallucination, auditory | 11.60 | 9.85 | 5 | 111292 | 11768 | 53226001 |
Breast cancer metastatic | 11.57 | 9.85 | 9 | 111288 | 15319 | 53222450 |
Nodule | 11.57 | 9.85 | 69 | 111228 | 17360 | 53220409 |
Hypergammaglobulinaemia | 11.55 | 9.85 | 9 | 111288 | 484 | 53237285 |
Respiratory gas exchange disorder | 11.55 | 9.85 | 9 | 111288 | 484 | 53237285 |
Moraxella infection | 11.54 | 9.85 | 8 | 111289 | 359 | 53237410 |
Impetigo | 11.53 | 9.85 | 13 | 111284 | 1120 | 53236649 |
Renal cell carcinoma | 11.49 | 9.85 | 24 | 111273 | 3555 | 53234214 |
Knee arthroplasty | 11.47 | 9.85 | 34 | 111263 | 33535 | 53204234 |
Mucosal necrosis | 11.47 | 9.85 | 4 | 111293 | 37 | 53237732 |
Renal colic | 11.46 | 9.85 | 14 | 111283 | 1313 | 53236456 |
Rheumatic fever | 11.43 | 9.85 | 6 | 111291 | 12598 | 53225171 |
Cervical incompetence | 11.43 | 9.85 | 10 | 111287 | 633 | 53237136 |
Cervix carcinoma | 11.42 | 9.85 | 21 | 111276 | 2834 | 53234935 |
Sciatica | 11.41 | 9.85 | 81 | 111216 | 21612 | 53216157 |
Angina pectoris | 11.41 | 9.85 | 27 | 111270 | 28698 | 53209071 |
Cafe au lait spots | 11.37 | 9.85 | 4 | 111293 | 38 | 53237731 |
Hidradenitis | 11.36 | 9.85 | 19 | 111278 | 2379 | 53235390 |
Mental disorder | 11.28 | 9.85 | 21 | 111276 | 24355 | 53213414 |
Blood immunoglobulin M increased | 11.25 | 9.85 | 7 | 111290 | 261 | 53237508 |
Ill-defined disorder | 11.20 | 9.85 | 59 | 111238 | 49385 | 53188384 |
Proctocolectomy | 11.19 | 9.85 | 4 | 111293 | 40 | 53237729 |
Faecal calprotectin abnormal | 11.19 | 9.85 | 4 | 111293 | 40 | 53237729 |
Anuria | 11.17 | 9.85 | 6 | 111291 | 12434 | 53225335 |
Cholecystitis chronic | 11.14 | 9.85 | 4 | 111293 | 10514 | 53227255 |
Precursor T-lymphoblastic lymphoma/leukaemia | 11.10 | 9.85 | 4 | 111293 | 41 | 53237728 |
Vertigo | 11.05 | 9.85 | 70 | 111227 | 56011 | 53181758 |
Hypocomplementaemia | 11.03 | 9.85 | 6 | 111291 | 173 | 53237596 |
Dyspepsia | 11.02 | 9.85 | 106 | 111191 | 77494 | 53160275 |
Neuroendocrine carcinoma metastatic | 11.00 | 9.85 | 6 | 111291 | 174 | 53237595 |
Skin laceration | 11.00 | 9.85 | 15 | 111282 | 19696 | 53218073 |
Haemophilus infection | 10.99 | 9.85 | 12 | 111285 | 997 | 53236772 |
Myoclonus | 10.98 | 9.85 | 10 | 111287 | 15754 | 53222015 |
Hypoglycaemic seizure | 10.98 | 9.85 | 9 | 111288 | 521 | 53237248 |
Anaphylactic shock | 10.92 | 9.85 | 18 | 111279 | 21875 | 53215894 |
Renal phospholipidosis | 10.90 | 9.85 | 5 | 111292 | 99 | 53237670 |
Appendicectomy | 10.87 | 9.85 | 20 | 111277 | 2701 | 53235068 |
Feeling jittery | 10.86 | 9.85 | 52 | 111245 | 12031 | 53225738 |
Renal transplant | 10.86 | 9.85 | 14 | 111283 | 1386 | 53236383 |
Amnesia | 10.85 | 9.85 | 53 | 111244 | 45235 | 53192534 |
Behcet's syndrome | 10.81 | 9.85 | 5 | 111292 | 101 | 53237668 |
Infertility | 10.81 | 9.85 | 10 | 111287 | 681 | 53237088 |
Swollen joint count increased | 10.81 | 9.85 | 5 | 111292 | 11285 | 53226484 |
Dermatitis psoriasiform | 10.73 | 9.85 | 16 | 111281 | 1816 | 53235953 |
Primary effusion lymphoma | 10.72 | 9.85 | 3 | 111294 | 12 | 53237757 |
Pulmonary venous thrombosis | 10.72 | 9.85 | 3 | 111294 | 12 | 53237757 |
Immunoglobulins decreased | 10.70 | 9.85 | 12 | 111285 | 1027 | 53236742 |
Pancreatitis acute | 10.70 | 9.85 | 92 | 111205 | 26017 | 53211752 |
Small intestinal perforation | 10.67 | 9.85 | 14 | 111283 | 1411 | 53236358 |
Eye swelling | 10.67 | 9.85 | 18 | 111279 | 21676 | 53216093 |
Anal skin tags | 10.66 | 9.85 | 7 | 111290 | 287 | 53237482 |
Lentigo maligna | 10.64 | 9.85 | 6 | 111291 | 186 | 53237583 |
Intra-abdominal fluid collection | 10.64 | 9.85 | 18 | 111279 | 2275 | 53235494 |
Steroid dependence | 10.61 | 9.85 | 7 | 111290 | 289 | 53237480 |
Intestinal dilatation | 10.61 | 9.85 | 15 | 111282 | 1623 | 53236146 |
Sepsis | 10.53 | 9.85 | 389 | 110908 | 146040 | 53091729 |
Hodgkin's disease stage II | 10.53 | 9.85 | 3 | 111294 | 13 | 53237756 |
Intestinal fistula infection | 10.53 | 9.85 | 3 | 111294 | 13 | 53237756 |
Poor venous access | 10.52 | 9.85 | 45 | 111252 | 9930 | 53227839 |
Pharyngeal oedema | 10.51 | 9.85 | 9 | 111288 | 14604 | 53223165 |
Histiocytic necrotising lymphadenitis | 10.46 | 9.85 | 4 | 111293 | 49 | 53237720 |
Vasculitis necrotising | 10.42 | 9.85 | 9 | 111288 | 560 | 53237209 |
Metastases to liver | 10.42 | 9.85 | 18 | 111279 | 21478 | 53216291 |
Stoma site extravasation | 10.39 | 9.85 | 8 | 111289 | 423 | 53237346 |
Mycetoma mycotic | 10.35 | 9.85 | 3 | 111294 | 14 | 53237755 |
Ubiquinone decreased | 10.35 | 9.85 | 3 | 111294 | 14 | 53237755 |
Mouth ulceration | 10.32 | 9.85 | 100 | 111197 | 29226 | 53208543 |
Panic attack | 10.32 | 9.85 | 18 | 111279 | 21400 | 53216369 |
Intestine transplant rejection | 10.32 | 9.85 | 4 | 111293 | 51 | 53237718 |
Bone tuberculosis | 10.30 | 9.85 | 6 | 111291 | 198 | 53237571 |
Evans syndrome | 10.22 | 9.85 | 6 | 111291 | 201 | 53237568 |
Bronchostenosis | 10.19 | 9.85 | 8 | 111289 | 435 | 53237334 |
Ischaemic nephropathy | 10.18 | 9.85 | 3 | 111294 | 15 | 53237754 |
Cholestasis | 10.17 | 9.85 | 98 | 111199 | 28597 | 53209172 |
Spinal cord disorder | 10.17 | 9.85 | 13 | 111284 | 1277 | 53236492 |
Urticarial vasculitis | 10.08 | 9.85 | 9 | 111288 | 585 | 53237184 |
Febrile infection | 10.08 | 9.85 | 13 | 111284 | 1288 | 53236481 |
Diabetes mellitus inadequate control | 10.06 | 9.85 | 9 | 111288 | 14301 | 53223468 |
Infective aortitis | 10.02 | 9.85 | 3 | 111294 | 16 | 53237753 |
Chest discomfort | 9.99 | 9.85 | 147 | 111150 | 99548 | 53138221 |
Bedridden | 9.98 | 9.85 | 4 | 111293 | 9833 | 53227936 |
Autoimmune haemolytic anaemia | 9.98 | 9.85 | 26 | 111271 | 4445 | 53233324 |
Steroid diabetes | 9.95 | 9.85 | 11 | 111286 | 927 | 53236842 |
Transplant failure | 9.95 | 9.85 | 14 | 111283 | 1508 | 53236261 |
Herpes zoster | 9.94 | 9.85 | 213 | 111084 | 73806 | 53163963 |
Nail disorder | 9.93 | 9.85 | 4 | 111293 | 9801 | 53227968 |
Pneumothorax spontaneous | 9.90 | 9.85 | 9 | 111288 | 599 | 53237170 |
Gingival graft | 9.87 | 9.85 | 3 | 111294 | 17 | 53237752 |
Portal venous gas | 9.86 | 9.85 | 4 | 111293 | 58 | 53237711 |
Breast adenoma | 9.86 | 9.85 | 4 | 111293 | 58 | 53237711 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Colitis ulcerative | 722.77 | 10.53 | 437 | 63032 | 16614 | 32433443 |
Drug ineffective | 355.14 | 10.53 | 1581 | 61888 | 381896 | 32068161 |
Off label use | 320.18 | 10.53 | 1311 | 62158 | 305009 | 32145048 |
Drug eruption | 266.44 | 10.53 | 252 | 63217 | 18914 | 32431143 |
Death | 263.77 | 10.53 | 217 | 63252 | 382300 | 32067757 |
Hepatosplenic T-cell lymphoma | 258.44 | 10.53 | 76 | 63393 | 408 | 32449649 |
Crohn's disease | 252.75 | 10.53 | 137 | 63332 | 4208 | 32445849 |
Post transplant lymphoproliferative disorder | 225.30 | 10.53 | 141 | 63328 | 5693 | 32444364 |
Intestinal stenosis | 218.83 | 10.53 | 97 | 63372 | 1898 | 32448159 |
Cytomegalovirus infection | 200.62 | 10.53 | 248 | 63221 | 25216 | 32424841 |
Nodular regenerative hyperplasia | 196.49 | 10.53 | 69 | 63400 | 702 | 32449355 |
Epstein-Barr virus infection | 195.62 | 10.53 | 139 | 63330 | 6951 | 32443106 |
Fistula | 195.58 | 10.53 | 126 | 63343 | 5353 | 32444704 |
Product use issue | 173.03 | 10.53 | 343 | 63126 | 52434 | 32397623 |
Frequent bowel movements | 172.51 | 10.53 | 145 | 63324 | 9307 | 32440750 |
Lymphoproliferative disorder | 165.50 | 10.53 | 87 | 63382 | 2508 | 32447549 |
Anal abscess | 164.48 | 10.53 | 114 | 63355 | 5476 | 32444581 |
Hypersensitivity | 164.23 | 10.53 | 354 | 63115 | 57404 | 32392653 |
Hepatic function abnormal | 146.44 | 10.53 | 291 | 63178 | 44549 | 32405508 |
Ileal stenosis | 143.81 | 10.53 | 63 | 63406 | 1197 | 32448860 |
Drug abuse | 141.96 | 10.53 | 3 | 63466 | 80240 | 32369817 |
Diffuse large B-cell lymphoma | 138.55 | 10.53 | 122 | 63347 | 8340 | 32441717 |
Intentional product use issue | 136.71 | 10.53 | 273 | 63196 | 41938 | 32408119 |
Completed suicide | 136.29 | 10.53 | 12 | 63457 | 92505 | 32357552 |
Product use in unapproved indication | 129.12 | 10.53 | 419 | 63050 | 86785 | 32363272 |
Fall | 129.01 | 10.53 | 116 | 63353 | 196085 | 32253972 |
Therapeutic product effect decreased | 125.89 | 10.53 | 221 | 63248 | 30796 | 32419261 |
Disseminated tuberculosis | 123.75 | 10.53 | 68 | 63401 | 2146 | 32447911 |
Anal fistula | 122.88 | 10.53 | 87 | 63382 | 4324 | 32445733 |
Squamous cell carcinoma | 120.60 | 10.53 | 127 | 63342 | 10841 | 32439216 |
Intestinal obstruction | 119.96 | 10.53 | 174 | 63295 | 20624 | 32429433 |
Disease recurrence | 119.39 | 10.53 | 152 | 63317 | 15912 | 32434145 |
Cytomegalovirus colitis | 115.15 | 10.53 | 69 | 63400 | 2573 | 32447484 |
Haemophagocytic lymphohistiocytosis | 113.65 | 10.53 | 125 | 63344 | 11210 | 32438847 |
Transplant rejection | 112.12 | 10.53 | 117 | 63352 | 9882 | 32440175 |
Febrile neutropenia | 111.35 | 10.53 | 47 | 63422 | 119519 | 32330538 |
Pemphigus | 111.28 | 10.53 | 54 | 63415 | 1308 | 32448749 |
Hypotension | 111.23 | 10.53 | 156 | 63313 | 215954 | 32234103 |
Infusion related reaction | 109.01 | 10.53 | 261 | 63208 | 45338 | 32404719 |
Stomatitis | 104.62 | 10.53 | 238 | 63231 | 39991 | 32410066 |
Large intestinal stenosis | 103.80 | 10.53 | 52 | 63417 | 1352 | 32448705 |
Blood pressure fluctuation | 101.23 | 10.53 | 158 | 63311 | 19977 | 32430080 |
JC virus infection | 100.57 | 10.53 | 57 | 63412 | 1912 | 32448145 |
Pulmonary tuberculosis | 98.25 | 10.53 | 80 | 63389 | 4909 | 32445148 |
Urticaria | 97.90 | 10.53 | 297 | 63172 | 59317 | 32390740 |
Treatment failure | 97.77 | 10.53 | 228 | 63241 | 38935 | 32411122 |
Premature baby | 96.86 | 10.53 | 148 | 63321 | 18370 | 32431687 |
Leukopenia | 96.37 | 10.53 | 297 | 63172 | 59825 | 32390232 |
Acute febrile neutrophilic dermatosis | 93.05 | 10.53 | 47 | 63422 | 1244 | 32448813 |
Pancytopenia | 92.57 | 10.53 | 388 | 63081 | 90847 | 32359210 |
Malignant neoplasm progression | 90.63 | 10.53 | 21 | 63448 | 78475 | 32371582 |
Progressive multifocal leukoencephalopathy | 90.22 | 10.53 | 102 | 63367 | 9429 | 32440628 |
Intestinal fistula | 90.18 | 10.53 | 41 | 63428 | 853 | 32449204 |
Epstein-Barr virus associated lymphoproliferative disorder | 89.54 | 10.53 | 52 | 63417 | 1828 | 32448229 |
Myocardial infarction | 89.05 | 10.53 | 69 | 63400 | 125607 | 32324450 |
Pneumocystis jirovecii pneumonia | 87.89 | 10.53 | 143 | 63326 | 18727 | 32431330 |
Toxicity to various agents | 87.16 | 10.53 | 133 | 63336 | 177908 | 32272149 |
Somnolence | 87.14 | 10.53 | 47 | 63422 | 103750 | 32346307 |
Dizziness | 86.84 | 10.53 | 174 | 63295 | 209444 | 32240613 |
Basal cell carcinoma | 84.37 | 10.53 | 135 | 63334 | 17433 | 32432624 |
Intestinal resection | 83.58 | 10.53 | 46 | 63423 | 1456 | 32448601 |
Faecal calprotectin increased | 83.45 | 10.53 | 45 | 63424 | 1367 | 32448690 |
Cushingoid | 82.12 | 10.53 | 56 | 63413 | 2618 | 32447439 |
Epistaxis | 80.46 | 10.53 | 266 | 63203 | 55589 | 32394468 |
Kidney transplant rejection | 80.31 | 10.53 | 87 | 63382 | 7668 | 32442389 |
Drug level below therapeutic | 79.95 | 10.53 | 66 | 63403 | 4129 | 32445928 |
Condition aggravated | 78.31 | 10.53 | 546 | 62923 | 155115 | 32294942 |
Human herpesvirus 8 infection | 76.73 | 10.53 | 36 | 63433 | 807 | 32449250 |
Small intestinal stenosis | 76.17 | 10.53 | 30 | 63439 | 430 | 32449627 |
Colitis | 75.45 | 10.53 | 189 | 63280 | 33762 | 32416295 |
Tuberculosis | 73.56 | 10.53 | 88 | 63381 | 8641 | 32441416 |
Acute kidney injury | 73.05 | 10.53 | 310 | 63159 | 293158 | 32156899 |
Erythema nodosum | 72.61 | 10.53 | 37 | 63432 | 998 | 32449059 |
Drug specific antibody present | 71.73 | 10.53 | 50 | 63419 | 2423 | 32447634 |
Cardiac failure congestive | 70.36 | 10.53 | 39 | 63430 | 84813 | 32365244 |
Confusional state | 69.92 | 10.53 | 107 | 63362 | 143008 | 32307049 |
Dyspnoea | 69.88 | 10.53 | 418 | 63051 | 361627 | 32088430 |
Drug level decreased | 69.72 | 10.53 | 74 | 63395 | 6372 | 32443685 |
Abdominal pain | 68.56 | 10.53 | 513 | 62956 | 149016 | 32301041 |
Squamous cell carcinoma of skin | 68.35 | 10.53 | 90 | 63379 | 9736 | 32440321 |
Diarrhoea haemorrhagic | 68.19 | 10.53 | 72 | 63397 | 6163 | 32443894 |
Coombs positive haemolytic anaemia | 67.90 | 10.53 | 33 | 63436 | 802 | 32449255 |
Inappropriate schedule of product administration | 67.57 | 10.53 | 220 | 63249 | 45605 | 32404452 |
Muscle spasms | 64.14 | 10.53 | 290 | 63179 | 70128 | 32379929 |
Herpes zoster | 62.61 | 10.53 | 171 | 63298 | 32170 | 32417887 |
Lymphopenia | 62.55 | 10.53 | 106 | 63363 | 14350 | 32435707 |
T-cell lymphoma | 61.60 | 10.53 | 33 | 63436 | 989 | 32449068 |
Plasma cell myeloma | 61.56 | 10.53 | 18 | 63451 | 57596 | 32392461 |
Nocardiosis | 61.49 | 10.53 | 54 | 63415 | 3677 | 32446380 |
Immunosuppression | 61.48 | 10.53 | 65 | 63404 | 5572 | 32444485 |
Abscess | 61.25 | 10.53 | 89 | 63380 | 10561 | 32439496 |
Non-cirrhotic portal hypertension | 61.03 | 10.53 | 22 | 63447 | 243 | 32449814 |
Bradycardia | 60.63 | 10.53 | 32 | 63437 | 71530 | 32378527 |
Colectomy | 60.54 | 10.53 | 38 | 63431 | 1541 | 32448516 |
Gastrointestinal inflammation | 60.48 | 10.53 | 50 | 63419 | 3134 | 32446923 |
Atrial fibrillation | 60.17 | 10.53 | 84 | 63385 | 116620 | 32333437 |
Drug intolerance | 60.05 | 10.53 | 225 | 63244 | 50010 | 32400047 |
Lung transplant rejection | 59.74 | 10.53 | 30 | 63439 | 784 | 32449273 |
Hand deformity | 59.71 | 10.53 | 42 | 63427 | 2065 | 32447992 |
Product dose omission issue | 58.93 | 10.53 | 68 | 63401 | 102507 | 32347550 |
Histoplasmosis disseminated | 58.49 | 10.53 | 33 | 63436 | 1097 | 32448960 |
Clear cell renal cell carcinoma | 58.11 | 10.53 | 32 | 63437 | 1014 | 32449043 |
Lymphadenitis | 58.10 | 10.53 | 39 | 63430 | 1776 | 32448281 |
Hyponatraemia | 57.90 | 10.53 | 37 | 63432 | 74476 | 32375581 |
Abdominal adhesions | 57.86 | 10.53 | 35 | 63434 | 1328 | 32448729 |
Meningitis listeria | 57.70 | 10.53 | 24 | 63445 | 399 | 32449658 |
B-cell lymphoma | 57.14 | 10.53 | 57 | 63412 | 4562 | 32445495 |
Cytomegalovirus viraemia | 56.98 | 10.53 | 68 | 63401 | 6659 | 32443398 |
Foetal exposure during pregnancy | 55.32 | 10.53 | 192 | 63277 | 41109 | 32408948 |
Epstein-Barr virus test positive | 55.12 | 10.53 | 25 | 63444 | 517 | 32449540 |
Dehydration | 55.09 | 10.53 | 105 | 63364 | 128853 | 32321204 |
Cardiac arrest | 54.69 | 10.53 | 65 | 63404 | 96711 | 32353346 |
Night sweats | 54.40 | 10.53 | 106 | 63363 | 15982 | 32434075 |
Epstein-Barr virus associated lymphoma | 53.98 | 10.53 | 26 | 63443 | 619 | 32449438 |
Immunoglobulin G4 related disease | 53.48 | 10.53 | 16 | 63453 | 92 | 32449965 |
Cytomegalovirus enteritis | 52.45 | 10.53 | 23 | 63446 | 438 | 32449619 |
Intestinal perforation | 52.25 | 10.53 | 75 | 63394 | 8800 | 32441257 |
Lymphoma | 51.86 | 10.53 | 83 | 63386 | 10717 | 32439340 |
Transplant dysfunction | 51.78 | 10.53 | 41 | 63428 | 2416 | 32447641 |
Haematochezia | 51.41 | 10.53 | 181 | 63288 | 39027 | 32411030 |
Overdose | 50.80 | 10.53 | 57 | 63412 | 87020 | 32363037 |
Therapeutic response shortened | 50.72 | 10.53 | 54 | 63415 | 4666 | 32445391 |
Kaposi's sarcoma | 50.62 | 10.53 | 29 | 63440 | 993 | 32449064 |
Defaecation urgency | 50.32 | 10.53 | 35 | 63434 | 1690 | 32448367 |
Small intestinal obstruction | 49.79 | 10.53 | 95 | 63374 | 14101 | 32435956 |
Decreased appetite | 49.03 | 10.53 | 156 | 63313 | 160657 | 32289400 |
Chronic allograft nephropathy | 49.01 | 10.53 | 30 | 63439 | 1163 | 32448894 |
Cardio-respiratory arrest | 48.97 | 10.53 | 24 | 63445 | 55965 | 32394092 |
Heart transplant rejection | 48.89 | 10.53 | 31 | 63438 | 1280 | 32448777 |
Renal cell carcinoma | 48.36 | 10.53 | 59 | 63410 | 5911 | 32444146 |
Intentional overdose | 48.26 | 10.53 | 11 | 63458 | 41590 | 32408467 |
Pain in extremity | 47.87 | 10.53 | 396 | 63073 | 118505 | 32331552 |
Pneumonia aspiration | 47.51 | 10.53 | 11 | 63458 | 41145 | 32408912 |
Syncope | 47.31 | 10.53 | 64 | 63405 | 90060 | 32359997 |
Polyhydramnios | 46.88 | 10.53 | 18 | 63451 | 240 | 32449817 |
Neuropathy peripheral | 46.44 | 10.53 | 49 | 63420 | 76933 | 32373124 |
Portal hypertension | 46.35 | 10.53 | 48 | 63421 | 4016 | 32446041 |
Type 2 lepra reaction | 46.04 | 10.53 | 20 | 63449 | 372 | 32449685 |
Granulomatosis with polyangiitis | 45.76 | 10.53 | 27 | 63442 | 978 | 32449079 |
Myasthenia gravis | 45.37 | 10.53 | 45 | 63424 | 3577 | 32446480 |
Rebound effect | 44.82 | 10.53 | 35 | 63434 | 2021 | 32448036 |
Loss of consciousness | 44.16 | 10.53 | 58 | 63411 | 82649 | 32367408 |
Peliosis hepatis | 44.07 | 10.53 | 12 | 63457 | 46 | 32450011 |
Blood glucose increased | 43.46 | 10.53 | 38 | 63431 | 65203 | 32384854 |
Histoplasmosis | 43.43 | 10.53 | 29 | 63440 | 1309 | 32448748 |
Acute myocardial infarction | 43.36 | 10.53 | 27 | 63442 | 55122 | 32394935 |
Lymphocytopenia neonatal | 42.58 | 10.53 | 9 | 63460 | 6 | 32450051 |
Insomnia | 42.58 | 10.53 | 82 | 63387 | 100266 | 32349791 |
Aspergillus infection | 42.51 | 10.53 | 79 | 63390 | 11495 | 32438562 |
Chronic obstructive pulmonary disease | 42.48 | 10.53 | 21 | 63448 | 48732 | 32401325 |
Systemic lupus erythematosus | 41.64 | 10.53 | 39 | 63430 | 2887 | 32447170 |
Rheumatoid factor negative | 40.86 | 10.53 | 23 | 63446 | 761 | 32449296 |
Aggression | 40.82 | 10.53 | 13 | 63456 | 39376 | 32410681 |
Delirium | 39.87 | 10.53 | 18 | 63451 | 44028 | 32406029 |
Hypoglycaemia | 39.57 | 10.53 | 29 | 63440 | 54353 | 32395704 |
Rash | 39.55 | 10.53 | 243 | 63226 | 209090 | 32240967 |
Clostridium difficile infection | 39.45 | 10.53 | 99 | 63370 | 17697 | 32432360 |
Neuroendocrine carcinoma of the skin | 39.33 | 10.53 | 21 | 63448 | 625 | 32449432 |
Bronchopulmonary aspergillosis | 38.96 | 10.53 | 84 | 63385 | 13603 | 32436454 |
Inflammatory bowel disease | 38.63 | 10.53 | 35 | 63434 | 2483 | 32447574 |
Extrapulmonary tuberculosis | 38.62 | 10.53 | 13 | 63456 | 115 | 32449942 |
Abscess intestinal | 38.44 | 10.53 | 28 | 63441 | 1455 | 32448602 |
Therapeutic product effect incomplete | 38.17 | 10.53 | 171 | 63298 | 41170 | 32408887 |
Anal fissure | 38.03 | 10.53 | 37 | 63432 | 2872 | 32447185 |
Candida infection | 37.80 | 10.53 | 94 | 63375 | 16709 | 32433348 |
Abnormal behaviour | 37.45 | 10.53 | 4 | 63465 | 26462 | 32423595 |
Infection reactivation | 37.37 | 10.53 | 25 | 63444 | 1132 | 32448925 |
Mycobacterial infection | 37.19 | 10.53 | 31 | 63438 | 1965 | 32448092 |
Cardiac failure | 37.10 | 10.53 | 77 | 63392 | 91596 | 32358461 |
Cholangitis sclerosing | 37.02 | 10.53 | 24 | 63445 | 1030 | 32449027 |
Pancreatitis | 36.89 | 10.53 | 160 | 63309 | 37991 | 32412066 |
Cutaneous T-cell lymphoma | 36.38 | 10.53 | 27 | 63442 | 1444 | 32448613 |
Rectal fissure | 36.09 | 10.53 | 16 | 63453 | 313 | 32449744 |
Mycoplasma infection | 36.04 | 10.53 | 16 | 63453 | 314 | 32449743 |
International normalised ratio increased | 35.87 | 10.53 | 26 | 63443 | 49009 | 32401048 |
Arthralgia | 35.85 | 10.53 | 445 | 63024 | 148003 | 32302054 |
Hallucination | 35.84 | 10.53 | 30 | 63439 | 52589 | 32397468 |
Wrong technique in product usage process | 35.57 | 10.53 | 12 | 63457 | 35047 | 32415010 |
Lymphocyte count abnormal | 35.36 | 10.53 | 20 | 63449 | 668 | 32449389 |
Cerebrovascular accident | 35.36 | 10.53 | 72 | 63397 | 86248 | 32363809 |
Varicella zoster virus infection | 34.96 | 10.53 | 27 | 63442 | 1534 | 32448523 |
Respiratory arrest | 34.84 | 10.53 | 7 | 63462 | 28901 | 32421156 |
Lupus-like syndrome | 34.79 | 10.53 | 32 | 63437 | 2315 | 32447742 |
Red blood cell sedimentation rate abnormal | 34.22 | 10.53 | 31 | 63438 | 2199 | 32447858 |
Enterocutaneous fistula | 34.10 | 10.53 | 21 | 63448 | 823 | 32449234 |
Vasculitis | 34.03 | 10.53 | 61 | 63408 | 8632 | 32441425 |
Intestinal fibrosis | 33.44 | 10.53 | 11 | 63458 | 90 | 32449967 |
Therapeutic response decreased | 33.41 | 10.53 | 119 | 63350 | 25801 | 32424256 |
Coma | 33.31 | 10.53 | 21 | 63448 | 42591 | 32407466 |
Electrocardiogram QT prolonged | 33.16 | 10.53 | 18 | 63451 | 39623 | 32410434 |
Oedema peripheral | 33.14 | 10.53 | 113 | 63356 | 113978 | 32336079 |
Visceral leishmaniasis | 33.07 | 10.53 | 18 | 63451 | 557 | 32449500 |
Bone marrow failure | 32.91 | 10.53 | 132 | 63337 | 30272 | 32419785 |
Fatigue | 32.74 | 10.53 | 485 | 62984 | 350216 | 32099841 |
Gastrointestinal disorder | 32.45 | 10.53 | 133 | 63336 | 30798 | 32419259 |
Pyrexia | 32.37 | 10.53 | 835 | 62634 | 319133 | 32130924 |
Weight decreased | 32.37 | 10.53 | 476 | 62993 | 164342 | 32285715 |
Herpes simplex | 32.35 | 10.53 | 45 | 63424 | 5129 | 32444928 |
Anxiety | 32.21 | 10.53 | 89 | 63380 | 95916 | 32354141 |
Asthenia | 31.74 | 10.53 | 301 | 63168 | 235643 | 32214414 |
Obliterative bronchiolitis | 31.49 | 10.53 | 23 | 63446 | 1200 | 32448857 |
Abdominal abscess | 31.44 | 10.53 | 40 | 63429 | 4181 | 32445876 |
Orthostatic hypotension | 31.36 | 10.53 | 6 | 63463 | 25644 | 32424413 |
Steroid dependence | 31.25 | 10.53 | 12 | 63457 | 160 | 32449897 |
Low birth weight baby | 31.20 | 10.53 | 52 | 63417 | 6942 | 32443115 |
Hypokalaemia | 31.11 | 10.53 | 37 | 63432 | 55057 | 32395000 |
Gastrointestinal wall thickening | 31.07 | 10.53 | 22 | 63447 | 1093 | 32448964 |
Henoch-Schonlein purpura | 31.05 | 10.53 | 26 | 63443 | 1659 | 32448398 |
Complications of transplanted kidney | 30.93 | 10.53 | 40 | 63429 | 4250 | 32445807 |
Rectal abscess | 30.62 | 10.53 | 21 | 63448 | 991 | 32449066 |
Myopathy | 30.46 | 10.53 | 68 | 63401 | 11273 | 32438784 |
Gastrointestinal fistula | 30.37 | 10.53 | 15 | 63454 | 378 | 32449679 |
Urinary retention | 30.16 | 10.53 | 16 | 63453 | 35681 | 32414376 |
Foetal growth restriction | 29.86 | 10.53 | 38 | 63431 | 3974 | 32446083 |
Gastrointestinal lymphoma | 29.73 | 10.53 | 8 | 63461 | 29 | 32450028 |
Fistula discharge | 29.73 | 10.53 | 15 | 63454 | 396 | 32449661 |
Agitation | 29.67 | 10.53 | 41 | 63428 | 57195 | 32392862 |
Gastrointestinal haemorrhage | 29.55 | 10.53 | 80 | 63389 | 86802 | 32363255 |
Cow pox | 29.52 | 10.53 | 8 | 63461 | 30 | 32450027 |
Cystitis escherichia | 29.44 | 10.53 | 12 | 63457 | 189 | 32449868 |
Limb deformity | 29.34 | 10.53 | 16 | 63453 | 497 | 32449560 |
Dysgeusia | 29.11 | 10.53 | 7 | 63462 | 25524 | 32424533 |
Gait disturbance | 28.91 | 10.53 | 72 | 63397 | 80336 | 32369721 |
Rectal haemorrhage | 28.89 | 10.53 | 147 | 63322 | 37276 | 32412781 |
Acquired gene mutation | 28.87 | 10.53 | 22 | 63447 | 1225 | 32448832 |
Heart rate irregular | 28.81 | 10.53 | 76 | 63393 | 14002 | 32436055 |
Squamous cell carcinoma of the tongue | 28.66 | 10.53 | 12 | 63457 | 203 | 32449854 |
Papilloma viral infection | 28.64 | 10.53 | 15 | 63454 | 429 | 32449628 |
Mycobacterium chelonae infection | 28.56 | 10.53 | 17 | 63452 | 626 | 32449431 |
Enteritis | 28.49 | 10.53 | 51 | 63418 | 7210 | 32442847 |
Lung neoplasm | 28.47 | 10.53 | 40 | 63429 | 4601 | 32445456 |
Scleroderma | 28.44 | 10.53 | 23 | 63446 | 1397 | 32448660 |
Chronic gastrointestinal bleeding | 28.44 | 10.53 | 13 | 63456 | 274 | 32449783 |
Neutrophil count decreased | 28.43 | 10.53 | 30 | 63439 | 47109 | 32402948 |
Herpes zoster meningoencephalitis | 28.39 | 10.53 | 13 | 63456 | 275 | 32449782 |
Cytomegalovirus infection reactivation | 28.36 | 10.53 | 34 | 63435 | 3345 | 32446712 |
Therapeutic reaction time decreased | 28.24 | 10.53 | 17 | 63452 | 639 | 32449418 |
Angina pectoris | 28.19 | 10.53 | 13 | 63456 | 31413 | 32418644 |
Depressed level of consciousness | 28.17 | 10.53 | 23 | 63446 | 40824 | 32409233 |
Nephropathy toxic | 28.11 | 10.53 | 68 | 63401 | 11878 | 32438179 |
Hospitalisation | 27.53 | 10.53 | 33 | 63436 | 48938 | 32401119 |
Pouchitis | 27.52 | 10.53 | 17 | 63452 | 670 | 32449387 |
Balance disorder | 27.48 | 10.53 | 22 | 63447 | 39437 | 32410620 |
Actinic keratosis | 27.48 | 10.53 | 36 | 63433 | 3874 | 32446183 |
Splenomegaly | 27.46 | 10.53 | 76 | 63393 | 14401 | 32435656 |
Seizure | 27.43 | 10.53 | 107 | 63362 | 103747 | 32346310 |
Disease progression | 27.33 | 10.53 | 83 | 63386 | 86779 | 32363278 |
Listeria sepsis | 27.29 | 10.53 | 11 | 63458 | 168 | 32449889 |
Accidental overdose | 27.16 | 10.53 | 3 | 63466 | 19336 | 32430721 |
Intestinal anastomosis | 27.10 | 10.53 | 12 | 63457 | 234 | 32449823 |
Unresponsive to stimuli | 27.07 | 10.53 | 10 | 63459 | 27599 | 32422458 |
Disorientation | 26.78 | 10.53 | 16 | 63453 | 33409 | 32416648 |
Legionella infection | 26.77 | 10.53 | 15 | 63454 | 492 | 32449565 |
Liver transplant rejection | 26.74 | 10.53 | 27 | 63442 | 2192 | 32447865 |
Myasthenic syndrome | 26.58 | 10.53 | 14 | 63455 | 405 | 32449652 |
Complications of transplanted lung | 26.28 | 10.53 | 11 | 63458 | 186 | 32449871 |
Hepatosplenomegaly | 25.99 | 10.53 | 35 | 63434 | 3868 | 32446189 |
Ileostomy | 25.91 | 10.53 | 15 | 63454 | 524 | 32449533 |
Dyskinesia | 25.90 | 10.53 | 7 | 63462 | 23596 | 32426461 |
Myasthenia gravis crisis | 25.89 | 10.53 | 15 | 63454 | 525 | 32449532 |
Irritability | 25.78 | 10.53 | 8 | 63461 | 24646 | 32425411 |
Molluscum contagiosum | 25.70 | 10.53 | 12 | 63457 | 266 | 32449791 |
Contusion | 25.46 | 10.53 | 17 | 63452 | 33451 | 32416606 |
White blood cell count decreased | 25.35 | 10.53 | 92 | 63377 | 91106 | 32358951 |
Tachycardia | 25.29 | 10.53 | 75 | 63394 | 79013 | 32371044 |
Periumbilical abscess | 25.28 | 10.53 | 8 | 63461 | 57 | 32450000 |
Epstein Barr virus positive mucocutaneous ulcer | 25.17 | 10.53 | 12 | 63457 | 279 | 32449778 |
Graft versus host disease in lung | 25.13 | 10.53 | 15 | 63454 | 555 | 32449502 |
Meningitis cryptococcal | 25.03 | 10.53 | 26 | 63443 | 2183 | 32447874 |
Pyoderma gangrenosum | 24.97 | 10.53 | 20 | 63449 | 1198 | 32448859 |
Lupus nephritis | 24.90 | 10.53 | 12 | 63457 | 286 | 32449771 |
Malignant melanoma | 24.78 | 10.53 | 51 | 63418 | 7995 | 32442062 |
Subcutaneous abscess | 24.70 | 10.53 | 34 | 63435 | 3836 | 32446221 |
Diffuse large B-cell lymphoma stage IV | 24.64 | 10.53 | 12 | 63457 | 293 | 32449764 |
Osteonecrosis of jaw | 24.48 | 10.53 | 4 | 63465 | 19162 | 32430895 |
Transient ischaemic attack | 24.20 | 10.53 | 10 | 63459 | 25784 | 32424273 |
Phaeohyphomycosis | 24.02 | 10.53 | 17 | 63452 | 844 | 32449213 |
Plasmablastic lymphoma | 23.81 | 10.53 | 12 | 63457 | 316 | 32449741 |
Bone erosion | 23.71 | 10.53 | 28 | 63441 | 2711 | 32447346 |
Strongyloidiasis | 23.54 | 10.53 | 27 | 63442 | 2534 | 32447523 |
Drug resistance | 23.50 | 10.53 | 98 | 63371 | 22867 | 32427190 |
Body temperature fluctuation | 23.38 | 10.53 | 21 | 63448 | 1473 | 32448584 |
Hypocalcaemia | 23.20 | 10.53 | 8 | 63461 | 23046 | 32427011 |
Constipation | 23.15 | 10.53 | 148 | 63321 | 126225 | 32323832 |
Hydrops foetalis | 22.95 | 10.53 | 11 | 63458 | 259 | 32449798 |
Peritoneal abscess | 22.90 | 10.53 | 8 | 63461 | 80 | 32449977 |
Listeria encephalitis | 22.87 | 10.53 | 7 | 63462 | 44 | 32450013 |
Intestinal anastomosis complication | 22.72 | 10.53 | 9 | 63460 | 131 | 32449926 |
Narcotic bowel syndrome | 22.66 | 10.53 | 9 | 63460 | 132 | 32449925 |
Non-Hodgkin's lymphoma | 22.61 | 10.53 | 22 | 63447 | 1708 | 32448349 |
Autoimmune hepatitis | 22.54 | 10.53 | 33 | 63436 | 3942 | 32446115 |
Growth retardation | 22.51 | 10.53 | 22 | 63447 | 1717 | 32448340 |
Intestinal mass | 22.49 | 10.53 | 13 | 63456 | 453 | 32449604 |
Herpes simplex hepatitis | 22.47 | 10.53 | 8 | 63461 | 85 | 32449972 |
Lung abscess | 22.29 | 10.53 | 27 | 63442 | 2685 | 32447372 |
Cutaneous leishmaniasis | 22.26 | 10.53 | 10 | 63459 | 202 | 32449855 |
Coronary artery disease | 21.61 | 10.53 | 40 | 63429 | 49666 | 32400391 |
Stevens-Johnson syndrome | 21.59 | 10.53 | 5 | 63464 | 18704 | 32431353 |
Congenital cytomegalovirus infection | 21.45 | 10.53 | 6 | 63463 | 26 | 32450031 |
Eosinophilic granulomatosis with polyangiitis | 21.45 | 10.53 | 20 | 63449 | 1472 | 32448585 |
Depression | 21.38 | 10.53 | 107 | 63362 | 96953 | 32353104 |
Oesophageal atresia | 21.38 | 10.53 | 13 | 63456 | 498 | 32449559 |
Eosinophilic bronchitis | 21.35 | 10.53 | 9 | 63460 | 155 | 32449902 |
Immunosuppressant drug level increased | 21.30 | 10.53 | 37 | 63432 | 5108 | 32444949 |
Congenital cystic lung | 21.20 | 10.53 | 10 | 63459 | 227 | 32449830 |
Congenital oesophageal anomaly | 21.16 | 10.53 | 8 | 63461 | 102 | 32449955 |
Hepatitis | 21.11 | 10.53 | 97 | 63372 | 23596 | 32426461 |
Combined immunodeficiency | 21.10 | 10.53 | 7 | 63462 | 59 | 32449998 |
Hepatic enzyme increased | 21.01 | 10.53 | 134 | 63335 | 36903 | 32413154 |
Hyperkalaemia | 20.98 | 10.53 | 68 | 63401 | 69682 | 32380375 |
C-reactive protein increased | 20.84 | 10.53 | 163 | 63306 | 47939 | 32402118 |
Odynophagia | 20.59 | 10.53 | 36 | 63433 | 4995 | 32445062 |
Cytomegalovirus chorioretinitis | 20.50 | 10.53 | 30 | 63439 | 3582 | 32446475 |
Central nervous system lesion | 20.41 | 10.53 | 39 | 63430 | 5793 | 32444264 |
Optic neuritis | 20.39 | 10.53 | 29 | 63440 | 3373 | 32446684 |
Gastrointestinal mucosa hyperaemia | 20.39 | 10.53 | 10 | 63459 | 248 | 32449809 |
Haemolysis | 20.33 | 10.53 | 46 | 63423 | 7695 | 32442362 |
Varicella | 20.29 | 10.53 | 20 | 63449 | 1577 | 32448480 |
Osteoporosis | 20.25 | 10.53 | 61 | 63408 | 12121 | 32437936 |
Suicide attempt | 20.21 | 10.53 | 27 | 63442 | 38217 | 32411840 |
Autoimmune haemolytic anaemia | 20.16 | 10.53 | 33 | 63436 | 4341 | 32445716 |
Iron deficiency | 20.14 | 10.53 | 28 | 63441 | 3189 | 32446868 |
Laryngeal mass | 19.98 | 10.53 | 6 | 63463 | 35 | 32450022 |
Subdural haematoma | 19.94 | 10.53 | 7 | 63462 | 19946 | 32430111 |
Rhabdomyolysis | 19.94 | 10.53 | 66 | 63403 | 67199 | 32382858 |
Angioedema | 19.82 | 10.53 | 25 | 63444 | 36264 | 32413793 |
Cardiac disorder | 19.74 | 10.53 | 32 | 63437 | 41834 | 32408223 |
Pulmonary vasculitis | 19.63 | 10.53 | 8 | 63461 | 126 | 32449931 |
Mucocutaneous leishmaniasis | 19.61 | 10.53 | 7 | 63462 | 75 | 32449982 |
Ileal ulcer | 19.60 | 10.53 | 13 | 63456 | 580 | 32449477 |
Viral infection | 19.58 | 10.53 | 73 | 63396 | 16177 | 32433880 |
Lymphocytic infiltration | 19.57 | 10.53 | 14 | 63455 | 707 | 32449350 |
Product prescribing error | 19.57 | 10.53 | 7 | 63462 | 19710 | 32430347 |
Mucosal inflammation | 19.36 | 10.53 | 22 | 63447 | 33412 | 32416645 |
Metabolic acidosis | 19.29 | 10.53 | 31 | 63438 | 40668 | 32409389 |
Polyomavirus-associated nephropathy | 19.28 | 10.53 | 29 | 63440 | 3548 | 32446509 |
Gastrointestinal stoma complication | 19.20 | 10.53 | 18 | 63451 | 1334 | 32448723 |
Chorioretinopathy | 19.18 | 10.53 | 19 | 63450 | 1508 | 32448549 |
Tonsil cancer | 19.10 | 10.53 | 15 | 63454 | 873 | 32449184 |
Gastrointestinal stenosis | 19.05 | 10.53 | 7 | 63462 | 82 | 32449975 |
Granuloma | 18.94 | 10.53 | 25 | 63444 | 2710 | 32447347 |
Gallbladder polyp | 18.93 | 10.53 | 11 | 63458 | 387 | 32449670 |
Skin lesion | 18.88 | 10.53 | 84 | 63385 | 20157 | 32429900 |
Episcleritis | 18.86 | 10.53 | 8 | 63461 | 140 | 32449917 |
Protein deficiency | 18.73 | 10.53 | 4 | 63465 | 3 | 32450054 |
Asthma | 18.68 | 10.53 | 36 | 63433 | 44029 | 32406028 |
Amnesia | 18.67 | 10.53 | 13 | 63456 | 25023 | 32425034 |
Hypersensitivity vasculitis | 18.65 | 10.53 | 29 | 63440 | 3652 | 32446405 |
Chronic myeloid leukaemia | 18.59 | 10.53 | 25 | 63444 | 2759 | 32447298 |
Hodgkin's disease | 18.55 | 10.53 | 15 | 63454 | 911 | 32449146 |
Hyperglycaemia | 18.43 | 10.53 | 29 | 63440 | 38362 | 32411695 |
Lactic acidosis | 18.42 | 10.53 | 23 | 63446 | 33513 | 32416544 |
Jejunal stenosis | 18.36 | 10.53 | 6 | 63463 | 48 | 32450009 |
Autoimmune neutropenia | 18.30 | 10.53 | 10 | 63459 | 312 | 32449745 |
Drug level above therapeutic | 18.27 | 10.53 | 27 | 63442 | 3251 | 32446806 |
Herpes simplex test positive | 18.18 | 10.53 | 9 | 63460 | 228 | 32449829 |
Paracoccidioides infection | 18.12 | 10.53 | 7 | 63462 | 95 | 32449962 |
Drug specific antibody absent | 18.04 | 10.53 | 6 | 63463 | 51 | 32450006 |
Arthritis | 17.97 | 10.53 | 101 | 63368 | 26591 | 32423466 |
Aplasia pure red cell | 17.96 | 10.53 | 37 | 63432 | 5805 | 32444252 |
Large intestinal ulcer | 17.95 | 10.53 | 20 | 63449 | 1818 | 32448239 |
Acute pulmonary histoplasmosis | 17.73 | 10.53 | 7 | 63462 | 101 | 32449956 |
Chest pain | 17.68 | 10.53 | 156 | 63313 | 123981 | 32326076 |
Cytomegalovirus test positive | 17.61 | 10.53 | 29 | 63440 | 3833 | 32446224 |
Brain abscess | 17.57 | 10.53 | 25 | 63444 | 2909 | 32447148 |
Anal cancer | 17.53 | 10.53 | 11 | 63458 | 446 | 32449611 |
Serum sickness | 17.39 | 10.53 | 20 | 63449 | 1883 | 32448174 |
Infectious mononucleosis | 17.37 | 10.53 | 11 | 63458 | 453 | 32449604 |
Butterfly rash | 17.36 | 10.53 | 7 | 63462 | 107 | 32449950 |
Oesophagopleural fistula | 17.36 | 10.53 | 6 | 63463 | 58 | 32449999 |
Pruritus | 17.35 | 10.53 | 164 | 63305 | 128538 | 32321519 |
Pneumonia cytomegaloviral | 17.32 | 10.53 | 25 | 63444 | 2947 | 32447110 |
Skin cancer | 17.32 | 10.53 | 47 | 63422 | 8803 | 32441254 |
Laser therapy | 17.31 | 10.53 | 4 | 63465 | 6 | 32450051 |
Intestinal ulcer | 17.25 | 10.53 | 14 | 63455 | 855 | 32449202 |
Hemivertebra | 17.25 | 10.53 | 7 | 63462 | 109 | 32449948 |
Urinary tract infection | 17.22 | 10.53 | 89 | 63380 | 79982 | 32370075 |
Intestinal diaphragm disease | 17.16 | 10.53 | 9 | 63460 | 258 | 32449799 |
Disseminated cytomegaloviral infection | 16.94 | 10.53 | 8 | 63461 | 182 | 32449875 |
Cytomegalovirus duodenitis | 16.91 | 10.53 | 6 | 63463 | 63 | 32449994 |
Cytokine release syndrome | 16.90 | 10.53 | 3 | 63466 | 13532 | 32436525 |
Proctitis | 16.87 | 10.53 | 22 | 63447 | 2356 | 32447701 |
Retinal scar | 16.85 | 10.53 | 9 | 63460 | 268 | 32449789 |
Disturbance in attention | 16.85 | 10.53 | 13 | 63456 | 23740 | 32426317 |
Pancreatitis acute | 16.82 | 10.53 | 101 | 63368 | 27234 | 32422823 |
Pulmonary granuloma | 16.78 | 10.53 | 17 | 63452 | 1386 | 32448671 |
Acne | 16.76 | 10.53 | 51 | 63418 | 10191 | 32439866 |
Marrow hyperplasia | 16.64 | 10.53 | 15 | 63454 | 1057 | 32449000 |
Erectile dysfunction | 16.60 | 10.53 | 9 | 63460 | 19830 | 32430227 |
Cytomegalovirus syndrome | 16.58 | 10.53 | 7 | 63462 | 121 | 32449936 |
Relapsing fever | 16.55 | 10.53 | 8 | 63461 | 192 | 32449865 |
Splenic embolism | 16.51 | 10.53 | 8 | 63461 | 193 | 32449864 |
Testicular cancer metastatic | 16.50 | 10.53 | 6 | 63463 | 68 | 32449989 |
Gastrointestinal obstruction | 16.40 | 10.53 | 13 | 63456 | 767 | 32449290 |
Drug ineffective for unapproved indication | 16.35 | 10.53 | 62 | 63407 | 13850 | 32436207 |
Diabetes mellitus | 16.33 | 10.53 | 147 | 63322 | 45026 | 32405031 |
Fluid overload | 16.27 | 10.53 | 9 | 63460 | 19612 | 32430445 |
Gastroenteritis clostridial | 16.26 | 10.53 | 9 | 63460 | 288 | 32449769 |
Peripheral T-cell lymphoma unspecified stage IV | 16.13 | 10.53 | 5 | 63464 | 33 | 32450024 |
Listeriosis | 16.12 | 10.53 | 14 | 63455 | 939 | 32449118 |
Blood creatine phosphokinase increased | 16.12 | 10.53 | 41 | 63428 | 45435 | 32404622 |
Pseudopolyp | 16.11 | 10.53 | 8 | 63461 | 204 | 32449853 |
Anorectal stenosis | 15.97 | 10.53 | 4 | 63465 | 10 | 32450047 |
Aspartate aminotransferase increased | 15.94 | 10.53 | 71 | 63398 | 66358 | 32383699 |
Rectal discharge | 15.93 | 10.53 | 7 | 63462 | 134 | 32449923 |
Small intestine carcinoma | 15.93 | 10.53 | 11 | 63458 | 525 | 32449532 |
Platelet count decreased | 15.88 | 10.53 | 145 | 63324 | 114446 | 32335611 |
Spermatozoa progressive motility decreased | 15.79 | 10.53 | 7 | 63462 | 137 | 32449920 |
Stiff person syndrome | 15.79 | 10.53 | 7 | 63462 | 137 | 32449920 |
Aqueductal stenosis | 15.72 | 10.53 | 3 | 63466 | 0 | 32450057 |
Uveal melanoma | 15.72 | 10.53 | 3 | 63466 | 0 | 32450057 |
Arrhythmia | 15.71 | 10.53 | 28 | 63441 | 35275 | 32414782 |
Mental status changes | 15.67 | 10.53 | 32 | 63437 | 38305 | 32411752 |
Gastric fistula | 15.63 | 10.53 | 6 | 63463 | 80 | 32449977 |
Urinary incontinence | 15.62 | 10.53 | 8 | 63461 | 18199 | 32431858 |
Nausea | 15.46 | 10.53 | 493 | 62976 | 320356 | 32129701 |
Viral test positive | 15.46 | 10.53 | 8 | 63461 | 223 | 32449834 |
Neoplasm skin | 15.42 | 10.53 | 11 | 63458 | 553 | 32449504 |
Haematuria | 15.35 | 10.53 | 46 | 63423 | 48315 | 32401742 |
Full blood count decreased | 15.31 | 10.53 | 7 | 63462 | 17003 | 32433054 |
Rectal cancer | 15.21 | 10.53 | 21 | 63448 | 2376 | 32447681 |
Cardiac myxoma | 15.20 | 10.53 | 4 | 63465 | 13 | 32450044 |
Haemophilus bacteraemia | 15.20 | 10.53 | 4 | 63465 | 13 | 32450044 |
Haemorrhage intracranial | 15.16 | 10.53 | 6 | 63463 | 15881 | 32434176 |
Coloboma | 15.12 | 10.53 | 7 | 63462 | 152 | 32449905 |
Cryptococcal cutaneous infection | 15.11 | 10.53 | 6 | 63463 | 88 | 32449969 |
Gastrointestinal cancer metastatic | 14.99 | 10.53 | 6 | 63463 | 90 | 32449967 |
Sideroblastic anaemia | 14.98 | 10.53 | 8 | 63461 | 238 | 32449819 |
Herpes simplex colitis | 14.97 | 10.53 | 4 | 63465 | 14 | 32450043 |
Chronic graft versus host disease in intestine | 14.95 | 10.53 | 8 | 63461 | 239 | 32449818 |
Dry mouth | 14.93 | 10.53 | 15 | 63454 | 24104 | 32425953 |
Skin papilloma | 14.87 | 10.53 | 18 | 63451 | 1788 | 32448269 |
Hepatitis B | 14.82 | 10.53 | 36 | 63433 | 6305 | 32443752 |
Ejection fraction decreased | 14.79 | 10.53 | 8 | 63461 | 17650 | 32432407 |
Uveitis | 14.78 | 10.53 | 36 | 63433 | 6314 | 32443743 |
Testis cancer | 14.78 | 10.53 | 12 | 63457 | 733 | 32449324 |
Meconium peritonitis | 14.76 | 10.53 | 4 | 63465 | 15 | 32450042 |
Metastases to lymph nodes | 14.75 | 10.53 | 29 | 63440 | 4399 | 32445658 |
Functional gastrointestinal disorder | 14.74 | 10.53 | 20 | 63449 | 2226 | 32447831 |
Neonatal respiratory failure | 14.70 | 10.53 | 9 | 63460 | 349 | 32449708 |
Microscopic polyangiitis | 14.68 | 10.53 | 7 | 63462 | 163 | 32449894 |
Dementia | 14.63 | 10.53 | 4 | 63465 | 13382 | 32436675 |
Respiratory tract infection fungal | 14.63 | 10.53 | 12 | 63457 | 744 | 32449313 |
Mycobacterium kansasii infection | 14.60 | 10.53 | 8 | 63461 | 251 | 32449806 |
Ventricular tachycardia | 14.59 | 10.53 | 17 | 63452 | 25539 | 32424518 |
Pulmonary nocardiosis | 14.47 | 10.53 | 11 | 63458 | 610 | 32449447 |
Arthropathy | 14.42 | 10.53 | 84 | 63385 | 22405 | 32427652 |
Vomiting | 14.40 | 10.53 | 350 | 63119 | 235207 | 32214850 |
Cryptococcosis | 14.38 | 10.53 | 19 | 63450 | 2061 | 32447996 |
Pneumoperitoneum | 14.33 | 10.53 | 18 | 63451 | 1858 | 32448199 |
Tender joint count increased | 14.31 | 10.53 | 5 | 63464 | 50 | 32450007 |
Vitamin B1 decreased | 14.26 | 10.53 | 8 | 63461 | 263 | 32449794 |
Posterior reversible encephalopathy syndrome | 14.12 | 10.53 | 46 | 63423 | 9530 | 32440527 |
Lymph node tuberculosis | 14.10 | 10.53 | 10 | 63459 | 498 | 32449559 |
Extrapyramidal disorder | 14.08 | 10.53 | 3 | 63466 | 11892 | 32438165 |
Pneumocystis jirovecii infection | 14.03 | 10.53 | 16 | 63453 | 1492 | 32448565 |
Sleep disorder | 14.02 | 10.53 | 19 | 63450 | 26733 | 32423324 |
Poor venous access | 13.95 | 10.53 | 23 | 63446 | 3043 | 32447014 |
Dyspnoea exertional | 13.90 | 10.53 | 35 | 63434 | 38926 | 32411131 |
Peritoneal candidiasis | 13.84 | 10.53 | 4 | 63465 | 20 | 32450037 |
Disseminated cryptococcosis | 13.83 | 10.53 | 14 | 63455 | 1140 | 32448917 |
Therapy non-responder | 13.78 | 10.53 | 110 | 63359 | 32544 | 32417513 |
Unevaluable event | 13.75 | 10.53 | 28 | 63441 | 33558 | 32416499 |
Gastrointestinal scarring | 13.69 | 10.53 | 6 | 63463 | 114 | 32449943 |
Intentional self-injury | 13.68 | 10.53 | 5 | 63464 | 13895 | 32436162 |
Hepatobiliary cancer | 13.65 | 10.53 | 3 | 63466 | 3 | 32450054 |
Precursor T-lymphoblastic lymphoma/leukaemia stage I | 13.65 | 10.53 | 3 | 63466 | 3 | 32450054 |
Hepatic angiosarcoma | 13.65 | 10.53 | 3 | 63466 | 3 | 32450054 |
Oropharyngeal squamous cell carcinoma | 13.63 | 10.53 | 7 | 63462 | 192 | 32449865 |
Enterovesical fistula | 13.62 | 10.53 | 11 | 63458 | 667 | 32449390 |
Rash maculo-papular | 13.61 | 10.53 | 21 | 63448 | 28001 | 32422056 |
Appendiceal abscess | 13.57 | 10.53 | 5 | 63464 | 59 | 32449998 |
Small intestinal ulcer haemorrhage | 13.57 | 10.53 | 5 | 63464 | 59 | 32449998 |
Necrotising herpetic retinopathy | 13.52 | 10.53 | 4 | 63465 | 22 | 32450035 |
Pulmonary paracoccidioidomycosis | 13.52 | 10.53 | 4 | 63465 | 22 | 32450035 |
Overgrowth bacterial | 13.50 | 10.53 | 6 | 63463 | 118 | 32449939 |
Drug tolerance decreased | 13.49 | 10.53 | 15 | 63454 | 1361 | 32448696 |
Blood bilirubin decreased | 13.48 | 10.53 | 8 | 63461 | 293 | 32449764 |
Aphthous ulcer | 13.46 | 10.53 | 28 | 63441 | 4423 | 32445634 |
Neutropenia | 13.41 | 10.53 | 196 | 63273 | 141979 | 32308078 |
Campylobacter gastroenteritis | 13.39 | 10.53 | 12 | 63457 | 839 | 32449218 |
Drug interaction | 13.38 | 10.53 | 324 | 63145 | 217861 | 32232196 |
Pain | 13.36 | 10.53 | 272 | 63197 | 187284 | 32262773 |
Proctocolectomy | 13.35 | 10.53 | 5 | 63464 | 62 | 32449995 |
Skin hyperpigmentation | 13.34 | 10.53 | 23 | 63446 | 3155 | 32446902 |
Peritoneal tuberculosis | 13.31 | 10.53 | 9 | 63460 | 415 | 32449642 |
Cytomegalovirus oesophagitis | 13.29 | 10.53 | 9 | 63460 | 416 | 32449641 |
Small intestine adenocarcinoma | 13.28 | 10.53 | 6 | 63463 | 123 | 32449934 |
Altered state of consciousness | 13.26 | 10.53 | 14 | 63455 | 21983 | 32428074 |
Pseudolymphoma | 13.23 | 10.53 | 10 | 63459 | 550 | 32449507 |
Olfactory nerve disorder | 13.23 | 10.53 | 4 | 63465 | 24 | 32450033 |
Memory impairment | 13.21 | 10.53 | 38 | 63431 | 40441 | 32409616 |
Diffuse large B-cell lymphoma stage III | 13.21 | 10.53 | 5 | 63464 | 64 | 32449993 |
Gastrointestinal oedema | 13.20 | 10.53 | 15 | 63454 | 1393 | 32448664 |
Hyperhidrosis | 13.20 | 10.53 | 83 | 63386 | 71085 | 32378972 |
Cholangitis chronic | 13.19 | 10.53 | 3 | 63466 | 4 | 32450053 |
Injection site pain | 13.16 | 10.53 | 28 | 63441 | 33030 | 32417027 |
Colonic abscess | 13.15 | 10.53 | 9 | 63460 | 423 | 32449634 |
Thrombocytopenia | 13.12 | 10.53 | 207 | 63262 | 148092 | 32301965 |
Anal stenosis | 13.10 | 10.53 | 6 | 63463 | 127 | 32449930 |
Brachycephaly | 13.07 | 10.53 | 5 | 63464 | 66 | 32449991 |
Musculoskeletal discomfort | 13.06 | 10.53 | 36 | 63433 | 6804 | 32443253 |
Anaplastic large cell lymphoma T- and null-cell types | 13.06 | 10.53 | 6 | 63463 | 128 | 32449929 |
Myelitis transverse | 13.06 | 10.53 | 13 | 63456 | 1038 | 32449019 |
Anorectal disorder | 13.02 | 10.53 | 13 | 63456 | 1041 | 32449016 |
Migraine | 13.01 | 10.53 | 58 | 63411 | 13927 | 32436130 |
Lymphadenopathy | 12.98 | 10.53 | 94 | 63375 | 26988 | 32423069 |
Heart rate decreased | 12.97 | 10.53 | 89 | 63380 | 25111 | 32424946 |
Aspiration | 12.95 | 10.53 | 3 | 63466 | 11220 | 32438837 |
Transplant failure | 12.91 | 10.53 | 21 | 63448 | 2747 | 32447310 |
Chronic graft versus host disease in liver | 12.89 | 10.53 | 8 | 63461 | 318 | 32449739 |
Muscle rigidity | 12.88 | 10.53 | 3 | 63466 | 11183 | 32438874 |
Human ehrlichiosis | 12.88 | 10.53 | 7 | 63462 | 216 | 32449841 |
Brain stem syndrome | 12.86 | 10.53 | 9 | 63460 | 439 | 32449618 |
Placental disorder | 12.80 | 10.53 | 5 | 63464 | 70 | 32449987 |
Fluid retention | 12.79 | 10.53 | 20 | 63449 | 26530 | 32423527 |
Hair follicle tumour benign | 12.79 | 10.53 | 3 | 63466 | 5 | 32450052 |
Appendicectomy | 12.78 | 10.53 | 12 | 63457 | 891 | 32449166 |
Tuberculosis gastrointestinal | 12.76 | 10.53 | 7 | 63462 | 220 | 32449837 |
Antiphospholipid syndrome | 12.75 | 10.53 | 9 | 63460 | 445 | 32449612 |
Diaphragmatic injury | 12.73 | 10.53 | 6 | 63463 | 136 | 32449921 |
Polydipsia | 12.72 | 10.53 | 25 | 63444 | 3792 | 32446265 |
Epstein-Barr virus antibody positive | 12.64 | 10.53 | 8 | 63461 | 329 | 32449728 |
Pulmonary oedema | 12.63 | 10.53 | 47 | 63422 | 46220 | 32403837 |
Alternaria infection | 12.60 | 10.53 | 8 | 63461 | 331 | 32449726 |
Hepatitis cholestatic | 12.57 | 10.53 | 40 | 63429 | 8185 | 32441872 |
Prostatic specific antigen increased | 12.55 | 10.53 | 5 | 63464 | 13182 | 32436875 |
Toxic epidermal necrolysis | 12.53 | 10.53 | 13 | 63456 | 20580 | 32429477 |
American trypanosomiasis | 12.51 | 10.53 | 7 | 63462 | 229 | 32449828 |
Caesarean section | 12.48 | 10.53 | 18 | 63451 | 2121 | 32447936 |
Leiomyosarcoma | 12.45 | 10.53 | 6 | 63463 | 143 | 32449914 |
Sacroiliitis | 12.44 | 10.53 | 13 | 63456 | 1099 | 32448958 |
Anaplastic large cell lymphoma T- and null-cell types stage III | 12.44 | 10.53 | 3 | 63466 | 6 | 32450051 |
Actinic cheilitis | 12.44 | 10.53 | 3 | 63466 | 6 | 32450051 |
Leiomyoma | 12.44 | 10.53 | 3 | 63466 | 6 | 32450051 |
Gastrooesophageal sphincter insufficiency | 12.43 | 10.53 | 5 | 63464 | 76 | 32449981 |
Neuromyelitis optica spectrum disorder | 12.41 | 10.53 | 6 | 63463 | 144 | 32449913 |
Intentional product misuse | 12.39 | 10.53 | 33 | 63436 | 36018 | 32414039 |
Lymphocyte count | 12.37 | 10.53 | 5 | 63464 | 77 | 32449980 |
Oropharyngeal pain | 12.36 | 10.53 | 104 | 63365 | 31248 | 32418809 |
Scar | 12.25 | 10.53 | 32 | 63437 | 5861 | 32444196 |
Oedema | 12.24 | 10.53 | 46 | 63423 | 45101 | 32404956 |
Haematemesis | 12.22 | 10.53 | 22 | 63447 | 27613 | 32422444 |
Mycobacterium abscessus infection | 12.19 | 10.53 | 10 | 63459 | 620 | 32449437 |
Gastrointestinal stoma output decreased | 12.13 | 10.53 | 4 | 63465 | 33 | 32450024 |
Vasculitis necrotising | 12.02 | 10.53 | 10 | 63459 | 632 | 32449425 |
Cognitive disorder | 12.01 | 10.53 | 20 | 63449 | 25874 | 32424183 |
Vision blurred | 11.99 | 10.53 | 45 | 63424 | 44141 | 32405916 |
Eosinophilic myocarditis | 11.99 | 10.53 | 9 | 63460 | 490 | 32449567 |
Haemodialysis | 11.98 | 10.53 | 48 | 63421 | 10998 | 32439059 |
Death neonatal | 11.90 | 10.53 | 8 | 63461 | 365 | 32449692 |
Lip swelling | 11.88 | 10.53 | 6 | 63463 | 13759 | 32436298 |
Psoriasis | 11.86 | 10.53 | 48 | 63421 | 46075 | 32403982 |
Drug specific antibody | 11.83 | 10.53 | 7 | 63462 | 255 | 32449802 |
Diarrhoea | 11.82 | 10.53 | 587 | 62882 | 364215 | 32085842 |
Product administration error | 11.80 | 10.53 | 8 | 63461 | 15617 | 32434440 |
Laparotomy | 11.78 | 10.53 | 7 | 63462 | 257 | 32449800 |
Bacillary angiomatosis | 11.71 | 10.53 | 5 | 63464 | 89 | 32449968 |
Short-bowel syndrome | 11.70 | 10.53 | 7 | 63462 | 260 | 32449797 |
Blood sodium decreased | 11.70 | 10.53 | 9 | 63460 | 16465 | 32433592 |
Focal segmental glomerulosclerosis | 11.66 | 10.53 | 17 | 63452 | 2023 | 32448034 |
Stenotrophomonas infection | 11.63 | 10.53 | 16 | 63453 | 1804 | 32448253 |
Adenocarcinoma | 11.56 | 10.53 | 16 | 63453 | 1815 | 32448242 |
Rhegmatogenous retinal detachment | 11.54 | 10.53 | 4 | 63465 | 39 | 32450018 |
Xanthoma | 11.51 | 10.53 | 5 | 63464 | 93 | 32449964 |
Enterostomy | 11.46 | 10.53 | 5 | 63464 | 94 | 32449963 |
Rectal stenosis | 11.44 | 10.53 | 6 | 63463 | 172 | 32449885 |
Alanine aminotransferase increased | 11.44 | 10.53 | 98 | 63371 | 78381 | 32371676 |
Blood pressure decreased | 11.42 | 10.53 | 56 | 63413 | 51024 | 32399033 |
Congenital arterial malformation | 11.41 | 10.53 | 5 | 63464 | 95 | 32449962 |
Neoplasm progression | 11.31 | 10.53 | 13 | 63456 | 19645 | 32430412 |
Hypogammaglobulinaemia | 11.30 | 10.53 | 32 | 63437 | 6144 | 32443913 |
Haemoptysis | 11.29 | 10.53 | 31 | 63438 | 33494 | 32416563 |
Polychondritis | 11.28 | 10.53 | 6 | 63463 | 177 | 32449880 |
Diabetic ketoacidosis | 11.28 | 10.53 | 11 | 63458 | 17921 | 32432136 |
Angina unstable | 11.25 | 10.53 | 5 | 63464 | 12350 | 32437707 |
Opportunistic infection | 11.25 | 10.53 | 15 | 63454 | 1642 | 32448415 |
Proteinuria | 11.24 | 10.53 | 65 | 63404 | 17290 | 32432767 |
Iron deficiency anaemia | 11.21 | 10.53 | 43 | 63426 | 9658 | 32440399 |
Enterocolonic fistula | 11.18 | 10.53 | 5 | 63464 | 100 | 32449957 |
Neurological symptom | 11.15 | 10.53 | 23 | 63446 | 3612 | 32446445 |
Leiomyosarcoma metastatic | 11.12 | 10.53 | 3 | 63466 | 11 | 32450046 |
Diaphragmatic hernia | 11.10 | 10.53 | 7 | 63462 | 286 | 32449771 |
Accidental exposure to product | 11.08 | 10.53 | 4 | 63465 | 11198 | 32438859 |
Adverse drug reaction | 11.07 | 10.53 | 21 | 63448 | 25840 | 32424217 |
Therapy cessation | 11.06 | 10.53 | 9 | 63460 | 16004 | 32434053 |
Anti-myelin-associated glycoprotein antibodies positive | 10.92 | 10.53 | 3 | 63466 | 12 | 32450045 |
Pneumonia legionella | 10.91 | 10.53 | 15 | 63454 | 1690 | 32448367 |
Bile duct stenosis | 10.91 | 10.53 | 13 | 63456 | 1271 | 32448786 |
Withdrawal syndrome | 10.89 | 10.53 | 5 | 63464 | 12117 | 32437940 |
Acute respiratory failure | 10.89 | 10.53 | 25 | 63444 | 28703 | 32421354 |
Schizophrenia | 10.88 | 10.53 | 3 | 63466 | 9981 | 32440076 |
Latent tuberculosis | 10.88 | 10.53 | 12 | 63457 | 1079 | 32448978 |
Back pain | 10.85 | 10.53 | 152 | 63317 | 110901 | 32339156 |
Restlessness | 10.83 | 10.53 | 20 | 63449 | 24861 | 32425196 |
Dyspepsia | 10.81 | 10.53 | 31 | 63438 | 33024 | 32417033 |
Renal injury | 10.79 | 10.53 | 5 | 63464 | 12050 | 32438007 |
Anastomotic ulcer | 10.78 | 10.53 | 7 | 63462 | 301 | 32449756 |
Maternal drugs affecting foetus | 10.77 | 10.53 | 25 | 63444 | 4252 | 32445805 |
Mediastinum neoplasm | 10.73 | 10.53 | 3 | 63466 | 13 | 32450044 |
Perineal fistula | 10.73 | 10.53 | 3 | 63466 | 13 | 32450044 |
Hodgkin's disease nodular sclerosis | 10.73 | 10.53 | 3 | 63466 | 13 | 32450044 |
Post transplant distal limb syndrome | 10.70 | 10.53 | 7 | 63462 | 305 | 32449752 |
Immunosuppressant drug level decreased | 10.67 | 10.53 | 13 | 63456 | 1300 | 32448757 |
Skin laceration | 10.67 | 10.53 | 49 | 63420 | 11917 | 32438140 |
Gastroenterostomy | 10.65 | 10.53 | 4 | 63465 | 50 | 32450007 |
Anaemia megaloblastic | 10.62 | 10.53 | 6 | 63463 | 200 | 32449857 |
Anger | 10.56 | 10.53 | 5 | 63464 | 11899 | 32438158 |
Foetal cardiac disorder | 10.55 | 10.53 | 3 | 63466 | 14 | 32450043 |
Micrognathia | 10.54 | 10.53 | 7 | 63462 | 313 | 32449744 |
Source | Code | Description |
---|---|---|
ATC | L04AX01 | ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS IMMUNOSUPPRESSANTS IMMUNOSUPPRESSANTS Other immunosuppressants |
FDA CS | M0015066 | Nucleosides |
FDA CS | M0018169 | Purines |
FDA MoA | N0000000233 | Nucleic Acid Synthesis Inhibitors |
MeSH PA | D000963 | Antimetabolites |
MeSH PA | D000964 | Antimetabolites, Antineoplastic |
MeSH PA | D000970 | Antineoplastic Agents |
MeSH PA | D018501 | Antirheumatic Agents |
MeSH PA | D007155 | Immunologic Factors |
MeSH PA | D007166 | Immunosuppressive Agents |
MeSH PA | D009676 | Noxae |
FDA EPC | N0000175712 | Purine Antimetabolite |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Refractory idiopathic thrombocytopenic purpura | indication | 13172003 | |
Relapsing multiple sclerosis | indication | 24700007 | DOID:2377 |
Crohn's disease | indication | 34000006 | |
Pemphigus vulgaris | indication | 49420001 | DOID:0060851 |
Systemic lupus erythematosus | indication | 55464009 | DOID:9074 |
Ulcerative colitis | indication | 64766004 | DOID:8577 |
Rheumatoid arthritis | indication | 69896004 | DOID:7148 |
Bullous pemphigoid | indication | 77090002 | DOID:8506 |
Myasthenia gravis | indication | 91637004 | DOID:437 |
Polyarteritis nodosa | indication | 155441006 | DOID:9810 |
Behcet's disease | indication | 310701003 | DOID:13241 |
Dermatomyositis | indication | 396230008 | DOID:10223 |
Autoimmune hepatitis | indication | 408335007 | |
Refractory autoimmune haemolytic anaemia | indication | 413603009 | DOID:718 |
Prevention of Kidney Transplant Rejection | indication | ||
Polymyositis | off-label use | 31384009 | |
Prevention of Lung Transplant Rejection | off-label use | ||
Prevention of Cardiac Transplant Rejection | off-label use | ||
Prevention of Liver Transplant Rejection | off-label use | ||
Mycosis | contraindication | 3218000 | DOID:1564 |
Viral disease | contraindication | 34014006 | DOID:934 |
Hepatic vein thrombosis | contraindication | 38739001 | DOID:11512 |
Bacterial infectious disease | contraindication | 87628006 | |
Malignant lymphoma | contraindication | 118600007 | DOID:0060058 |
Liver function tests abnormal | contraindication | 166603001 | |
Acute pancreatitis | contraindication | 197456007 | DOID:2913 |
Impaired renal function disorder | contraindication | 197663003 | |
Anemia | contraindication | 271737000 | DOID:2355 |
Pregnancy, function | contraindication | 289908002 | |
Thrombocytopenic disorder | contraindication | 302215000 | DOID:1588 |
Bone marrow depression | contraindication | 307762000 | |
Hepatosplenic T-cell lymphoma | contraindication | 445406001 | |
Thiopurine S-Methyltransferase Deficiency | contraindication | ||
Severe Leukopenia | contraindication | ||
Protozoal Infection | contraindication |
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 8.28 | acidic |
pKa2 | 3.24 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Multidrug resistance-associated protein 4 | Transporter | WOMBAT-PK | |||||||
Ras-related C3 botulinum toxin substrate 1 | Enzyme | WOMBAT-PK | |||||||
ATP-binding cassette sub-family G member 2 | Transporter | WOMBAT-PK | |||||||
Multidrug resistance-associated protein 5 | Transporter | WOMBAT-PK | |||||||
Thiopurine S-methyltransferase | Enzyme | WOMBAT-PK |
ID | Source |
---|---|
4018766 | VUID |
N0000147069 | NUI |
D00238 | KEGG_DRUG |
55774-33-9 | SECONDARY_CAS_RN |
1256 | RXNORM |
C0004482 | UMLSCUI |
CHEMBL1542 | ChEMBL_ID |
DB00993 | DRUGBANK_ID |
CHEMBL1200400 | ChEMBL_ID |
D001379 | MESH_DESCRIPTOR_UI |
2265 | PUBCHEM_CID |
7120 | IUPHAR_LIGAND_ID |
1291 | INN_ID |
MRK240IY2L | UNII |
3341 | MMSL |
4234 | MMSL |
4235 | MMSL |
6041 | MMSL |
d00024 | MMSL |
003419 | NDDF |
004123 | NDDF |
111165009 | SNOMEDCT_US |
372574004 | SNOMEDCT_US |
67221004 | SNOMEDCT_US |
4018766 | VANDF |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Azathioprine Sodium | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0143-9566 | INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION | 100 mg | INTRAVENOUS | ANDA | 22 sections |
Azathioprine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-1005 | TABLET | 50 mg | ORAL | ANDA | 23 sections |
Azathioprine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-484 | TABLET | 50 mg | ORAL | ANDA | 20 sections |
Azathioprine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 33261-758 | TABLET | 50 mg | ORAL | ANDA | 20 sections |
AZATHIOPRINE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 42291-071 | TABLET | 50 mg | ORAL | ANDA | 19 sections |
Azathioprine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 43353-745 | TABLET | 50 mg | ORAL | ANDA | 23 sections |
Azathioprine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51407-182 | TABLET | 50 mg | ORAL | ANDA | 14 sections |
IMURAN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 54766-590 | TABLET | 50 mg | ORAL | NDA | 23 sections |
Azathioprine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 54868-5310 | TABLET | 50 mg | ORAL | ANDA | 20 sections |
AZATHIOPRINE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 60219-1076 | TABLET | 50 mg | ORAL | ANDA | 19 sections |
AZATHIOPRINE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 60219-2036 | TABLET | 75 mg | ORAL | ANDA | 19 sections |
AZATHIOPRINE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 60219-2037 | TABLET | 100 mg | ORAL | ANDA | 19 sections |
IMURAN | HUMAN PRESCRIPTION DRUG LABEL | 1 | 65483-590 | TABLET | 50 mg | ORAL | NDA | 23 sections |
Azasan | HUMAN PRESCRIPTION DRUG LABEL | 1 | 65649-231 | TABLET | 75 mg | ORAL | ANDA | 13 sections |
Azasan | HUMAN PRESCRIPTION DRUG LABEL | 1 | 65649-241 | TABLET | 100 mg | ORAL | ANDA | 13 sections |
Azathioprine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 65841-602 | TABLET | 50 mg | ORAL | ANDA | 1 sections |
Azathioprine | Human Prescription Drug Label | 1 | 67877-492 | TABLET | 25 mg | ORAL | ANDA | 21 sections |
Azathioprine | Human Prescription Drug Label | 1 | 67877-493 | TABLET | 50 mg | ORAL | ANDA | 21 sections |
Azathioprine | Human Prescription Drug Label | 1 | 67877-494 | TABLET | 75 mg | ORAL | ANDA | 21 sections |
Azathioprine | Human Prescription Drug Label | 1 | 67877-495 | TABLET | 100 mg | ORAL | ANDA | 21 sections |
Azathioprine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 68084-229 | TABLET | 50 mg | ORAL | ANDA | 20 sections |
Azathioprine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 68382-003 | TABLET | 50 1 | ORAL | ANDA | 20 sections |
Azathioprine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 68382-118 | TABLET | 25 1 | ORAL | ANDA | 20 sections |
Azathioprine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 68382-119 | TABLET | 75 1 | ORAL | ANDA | 20 sections |
Azathioprine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 68382-120 | TABLET | 100 1 | ORAL | ANDA | 20 sections |
Azathioprine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 68462-502 | TABLET | 50 mg | ORAL | ANDA | 14 sections |
Azathioprine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 68462-502 | TABLET | 50 mg | ORAL | ANDA | 14 sections |
Azathioprine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 70771-1139 | TABLET | 25 1 | ORAL | ANDA | 1 sections |
Azathioprine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 70771-1140 | TABLET | 75 1 | ORAL | ANDA | 1 sections |
Azathioprine | HUMAN PRESCRIPTION DRUG LABEL | 1 | 70771-1141 | TABLET | 100 1 | ORAL | ANDA | 1 sections |