azathioprine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
269 446-86-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • BW 57-322
  • azathioprine sulfate
  • azathioprine
  • azamune
  • azanin
  • azathioprin
  • azathropine
  • azothioprine
  • azathioprine sodium
An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
  • Molecular weight: 277.26
  • Formula: C9H7N7O2S
  • CLOGP: 0.51
  • LIPINSKI: 0
  • HAC: 9
  • HDO: 1
  • TPSA: 115.42
  • ALOGS: -2.41
  • ROTB: 3

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.15 g O
0.15 g P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 10 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 1 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 18.03 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 60 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

DateAgencyCompanyOrphan
March 20, 1968 FDA PROMETHEUS LABS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 2298.57 35.09 951 4948 100673 2251513
Rheumatoid arthritis 1316.16 35.09 413 5486 18727 2333459
Drug intolerance 1285.82 35.09 376 5523 13341 2338845
Treatment failure 881.55 35.09 244 5655 6995 2345191
Blood iron abnormal 762.95 35.09 116 5783 58 2352128
Exposure during pregnancy 672.10 35.09 270 5629 24949 2327237
Pancytopenia 652.11 35.09 215 5684 11237 2340949
Maternal exposure during pregnancy 638.97 35.09 226 5673 14637 2337549
Product use in unapproved indication 572.74 35.09 194 5705 11006 2341180
Drug hypersensitivity 518.87 35.09 272 5627 46371 2305815
Off label use 518.66 35.09 318 5581 73280 2278906
Condition aggravated 459.31 35.09 222 5677 31757 2320429
Pneumonia 440.97 35.09 249 5650 49047 2303139
Cytomegalovirus infection 416.30 35.09 110 5789 2603 2349583
Leukopenia 407.01 35.09 147 5752 10049 2342137
Joint swelling 405.52 35.09 168 5731 16651 2335535
Arthralgia 392.55 35.09 239 5660 54046 2298140
Pyrexia 387.15 35.09 236 5663 53472 2298714
Synovitis 359.11 35.09 98 5801 2628 2349558
Contraindicated product administered 353.70 35.09 99 5800 2922 2349264
Epstein-Barr virus infection 348.22 35.09 80 5819 1031 2351155
Crohn's disease 346.37 35.09 117 5782 6538 2345648
Therapeutic product effect decreased 340.61 35.09 131 5768 10658 2341528
Cushingoid 331.32 35.09 69 5830 541 2351645
Abdominal pain 310.22 35.09 175 5724 34199 2317987
Non-Hodgkin's lymphoma 308.85 35.09 70 5829 845 2351341
Sepsis 303.47 35.09 141 5758 18347 2333839
Haemophagocytic lymphohistiocytosis 295.16 35.09 73 5826 1310 2350876
Post transplant lymphoproliferative disorder 294.50 35.09 61 5838 464 2351722
Nausea 274.33 35.09 258 5641 111931 2240255
Renal impairment 274.30 35.09 110 5789 9982 2342204
Diarrhoea 265.33 35.09 223 5676 83341 2268845
Arthritis 265.21 35.09 107 5792 9861 2342325
Rash 264.72 35.09 194 5705 59364 2292822
Bone erosion 261.36 35.09 56 5843 510 2351676
Weight decreased 259.96 35.09 146 5753 28225 2323961
Progressive multifocal leukoencephalopathy 256.59 35.09 72 5827 2140 2350046
Pancreatitis 247.32 35.09 96 5803 7983 2344203
Premature delivery 242.98 35.09 75 5824 3125 2349061
Therapeutic product effect incomplete 239.29 35.09 101 5798 10430 2341756
Diabetes mellitus 232.74 35.09 90 5809 7405 2344781
Interstitial lung disease 232.65 35.09 91 5808 7721 2344465
Anaemia 232.34 35.09 146 5753 34646 2317540
Foetal exposure during pregnancy 229.17 35.09 81 5818 5171 2347015
Infection 218.96 35.09 112 5787 17917 2334269
Synovial fluid analysis 216.23 35.09 31 5868 0 2352186
Elbow deformity 215.66 35.09 35 5864 44 2352142
Osteoporosis 215.36 35.09 74 5825 4340 2347846
Pneumocystis jirovecii pneumonia 214.46 35.09 63 5836 2210 2349976
SLE arthritis 212.29 35.09 35 5864 52 2352134
Therapeutic response decreased 211.35 35.09 83 5816 7112 2345074
Dyspnoea 201.21 35.09 186 5713 78547 2273639
Demyelination 200.08 35.09 50 5849 936 2351250
Bone marrow failure 197.06 35.09 74 5825 5612 2346574
Cytomegalovirus viraemia 191.36 35.09 42 5857 432 2351754
Tenosynovitis stenosans 190.32 35.09 34 5865 101 2352085
Scleritis 185.66 35.09 38 5861 270 2351916
Kaposi's sarcoma 182.26 35.09 37 5862 251 2351935
Musculoskeletal pain 181.77 35.09 84 5815 10746 2341440
Antinuclear antibody positive 180.84 35.09 47 5852 1035 2351151
Rheumatoid nodule 180.26 35.09 42 5857 576 2351610
Lymphopenia 179.86 35.09 56 5843 2398 2349788
Respiratory failure 178.67 35.09 89 5810 13439 2338747
Neutropenia 178.64 35.09 104 5795 21444 2330742
Premature baby 177.07 35.09 59 5840 3145 2349041
Abortion spontaneous 176.23 35.09 88 5811 13357 2338829
Musculoskeletal stiffness 174.93 35.09 85 5814 12162 2340024
Vomiting 174.76 35.09 165 5734 71437 2280749
Kidney transplant rejection 174.06 35.09 42 5857 675 2351511
Colitis ulcerative 172.55 35.09 56 5843 2746 2349440
Impaired gastric emptying 171.95 35.09 44 5855 909 2351277
Septic shock 171.35 35.09 71 5828 6983 2345203
Urinary tract infection 171.00 35.09 114 5785 29828 2322358
Diffuse large B-cell lymphoma 170.95 35.09 43 5856 827 2351359
Pleuritic pain 167.66 35.09 40 5859 611 2351575
Hypogammaglobulinaemia 167.64 35.09 41 5858 699 2351487
Premature labour 166.77 35.09 51 5848 2055 2350131
Bronchiectasis 166.70 35.09 43 5856 918 2351268
Systemic lupus erythematosus 164.87 35.09 60 5839 4161 2348025
Squamous cell carcinoma 164.82 35.09 46 5853 1337 2350849
C-reactive protein abnormal 159.52 35.09 40 5859 759 2351427
Anaphylactic reaction 155.76 35.09 73 5826 9632 2342554
C-reactive protein increased 155.44 35.09 64 5835 6191 2345995
Epstein-Barr virus associated lymphoproliferative disorder 152.98 35.09 32 5867 256 2351930
Crepitations 151.37 35.09 37 5862 629 2351557
Ulcer 146.61 35.09 45 5854 1835 2350351
Hypertension 146.19 35.09 100 5799 27261 2324925
Gastrointestinal disorder 145.96 35.09 68 5831 8849 2343337
Joint effusion 140.96 35.09 40 5859 1236 2350950
Alopecia 140.75 35.09 90 5809 21911 2330275
Proteinuria 139.81 35.09 48 5851 2802 2349384
Impaired work ability 135.54 35.09 42 5857 1768 2350418
Chest pain 134.34 35.09 96 5803 28041 2324145
Transplant rejection 134.09 35.09 38 5861 1168 2351018
Lung transplant rejection 133.97 35.09 25 5874 101 2352085
Multiple organ dysfunction syndrome 133.57 35.09 61 5838 7580 2344606
Aspergillus infection 133.12 35.09 36 5863 927 2351259
Red blood cell sedimentation rate increased 132.74 35.09 43 5856 2094 2350092
Lung disorder 132.42 35.09 57 5842 6155 2346031
Atelectasis 132.14 35.09 42 5857 1923 2350263
Synovial cyst 131.97 35.09 35 5864 835 2351351
Herpes zoster 131.35 35.09 65 5834 9660 2342526
Basal cell carcinoma 130.81 35.09 45 5854 2642 2349544
Haemoglobin decreased 130.54 35.09 80 5819 18071 2334115
Therapy non-responder 130.14 35.09 61 5838 8043 2344143
Pulmonary fibrosis 127.69 35.09 44 5855 2596 2349590
Fatigue 127.27 35.09 151 5748 84722 2267464
Lupus nephritis 127.01 35.09 28 5871 294 2351892
Tenderness 124.87 35.09 40 5859 1878 2350308
Conjunctivitis 124.01 35.09 42 5857 2351 2349835
Nodule 123.00 35.09 41 5858 2185 2350001
Therapeutic product effect variable 121.31 35.09 24 5875 140 2352046
Transaminases increased 120.99 35.09 49 5850 4538 2347648
Bursitis 120.98 35.09 39 5860 1869 2350317
Flank pain 120.54 35.09 37 5862 1508 2350678
Lymphadenopathy 120.51 35.09 52 5847 5646 2346540
Immunosuppression 120.28 35.09 34 5865 1035 2351151
Disease recurrence 119.81 35.09 45 5854 3406 2348780
Neoplasm malignant 119.38 35.09 50 5849 5043 2347143
Renal failure 118.49 35.09 74 5825 17275 2334911
Muscle fatigue 116.76 35.09 27 5872 357 2351829
Pain 116.46 35.09 124 5775 61733 2290453
Hepatic enzyme increased 116.23 35.09 60 5839 9742 2342444
Drug interaction 115.63 35.09 89 5810 29074 2323112
Colitis 114.82 35.09 49 5850 5177 2347009
Epicondylitis 114.69 35.09 25 5874 248 2351938
Caesarean section 112.48 35.09 45 5854 4036 2348150
Product use issue 112.14 35.09 63 5836 12106 2340080
Hypersensitivity 111.42 35.09 80 5819 23513 2328673
Red blood cell sedimentation rate abnormal 108.47 35.09 27 5872 496 2351690
Staphylococcal infection 107.38 35.09 47 5852 5279 2346907
Photophobia 106.25 35.09 37 5862 2252 2349934
Malaise 105.59 35.09 112 5787 55473 2296713
Lymphoproliferative disorder 104.26 35.09 27 5872 585 2351601
Acute myeloid leukaemia 103.84 35.09 38 5861 2672 2349514
Cushing's syndrome 102.08 35.09 28 5871 761 2351425
Klebsiella infection 101.11 35.09 28 5871 789 2351397
Feeling jittery 100.46 35.09 34 5865 1898 2350288
Toxicity to various agents 98.30 35.09 85 5814 32669 2319517
Mycobacterial infection 97.48 35.09 22 5877 259 2351927
Acute kidney injury 96.80 35.09 79 5820 28043 2324143
Normal newborn 96.62 35.09 30 5869 1270 2350916
Adverse drug reaction 96.16 35.09 50 5849 8233 2343953
Low birth weight baby 96.14 35.09 27 5872 802 2351384
Secondary immunodeficiency 96.00 35.09 18 5881 75 2352111
Erythema 95.81 35.09 75 5824 25084 2327102
Blood cholesterol increased 95.22 35.09 43 5856 5198 2346988
Pancreatitis acute 94.24 35.09 39 5860 3814 2348372
Lower respiratory tract infection 93.81 35.09 43 5856 5381 2346805
Squamous cell carcinoma of skin 93.47 35.09 26 5873 745 2351441
Live birth 92.63 35.09 29 5870 1262 2350924
Varicella zoster virus infection 92.18 35.09 22 5877 336 2351850
Thrombosis 91.51 35.09 50 5849 9094 2343092
Pulmonary tuberculosis 89.92 35.09 26 5873 859 2351327
Fibromyalgia 89.59 35.09 36 5863 3264 2348922
Premature rupture of membranes 89.32 35.09 26 5873 880 2351306
Neck pain 88.02 35.09 46 5853 7651 2344535
Pemphigus 87.50 35.09 24 5875 652 2351534
Disseminated tuberculosis 87.21 35.09 23 5876 536 2351650
Ankylosing spondylitis 86.74 35.09 24 5875 674 2351512
Thrombocytopenia 86.01 35.09 63 5836 19068 2333118
Ocular hyperaemia 85.69 35.09 37 5862 4019 2348167
Cholestasis 85.41 35.09 36 5863 3685 2348501
Pneumonia cytomegaloviral 85.22 35.09 20 5879 283 2351903
Pain in jaw 84.24 35.09 42 5857 6330 2345856
Aspartate aminotransferase increased 84.06 35.09 53 5846 12559 2339627
Mucormycosis 83.94 35.09 21 5878 394 2351792
Myelodysplastic syndrome 83.85 35.09 32 5867 2528 2349658
Dry eye 83.28 35.09 36 5863 3920 2348266
Vasculitis 83.27 35.09 31 5868 2287 2349899
Disease progression 83.02 35.09 59 5840 17036 2335150
B-cell lymphoma 82.98 35.09 23 5876 650 2351536
Skin ulcer 82.39 35.09 36 5863 4023 2348163
Epstein-Barr virus test positive 82.28 35.09 17 5882 127 2352059
Granulomatosis with polyangiitis 81.64 35.09 18 5881 189 2351997
Hepatitis 81.51 35.09 41 5858 6296 2345890
Pain in extremity 81.18 35.09 86 5813 42454 2309732
Staphylococcal sepsis 80.93 35.09 25 5874 1040 2351146
Liver function test abnormal 80.64 35.09 43 5856 7447 2344739
Meningitis cryptococcal 80.54 35.09 18 5881 202 2351984
Angiocentric lymphoma 80.34 35.09 16 5883 97 2352089
Lung infiltration 80.31 35.09 30 5869 2234 2349952
Peritonitis 80.11 35.09 31 5868 2543 2349643
Pruritus 79.85 35.09 86 5813 43254 2308932
Intentional product use issue 79.85 35.09 34 5865 3568 2348618
Groin pain 79.10 35.09 26 5873 1324 2350862
Adverse reaction 78.91 35.09 27 5872 1557 2350629
Disseminated intravascular coagulation 78.86 35.09 33 5866 3317 2348869
Iron deficiency anaemia 78.81 35.09 29 5870 2070 2350116
Pelvic fracture 78.64 35.09 26 5873 1349 2350837
Wheezing 78.30 35.09 40 5859 6344 2345842
Jaundice 77.85 35.09 38 5861 5470 2346716
Fungal endocarditis 77.42 35.09 13 5886 23 2352163
Headache 77.20 35.09 115 5784 80064 2272122
Blood creatinine increased 77.12 35.09 47 5852 10486 2341700
Myalgia 77.02 35.09 64 5835 23269 2328917
Pre-eclampsia 76.35 35.09 26 5873 1478 2350708
Joint stiffness 76.24 35.09 34 5865 3989 2348197
Eye pain 75.97 35.09 36 5863 4855 2347331
Atrial septal defect 75.21 35.09 25 5874 1319 2350867
Visual impairment 74.84 35.09 48 5851 11707 2340479
Exostosis 74.59 35.09 25 5874 1353 2350833
Pseudomonas infection 74.58 35.09 24 5875 1142 2351044
Mycobacterium avium complex infection 73.65 35.09 19 5880 405 2351781
Tuberculosis 73.63 35.09 27 5872 1908 2350278
White blood cell count decreased 73.01 35.09 56 5843 18152 2334034
Carpal tunnel syndrome 72.43 35.09 27 5872 1998 2350188
Foetal growth restriction 71.02 35.09 23 5876 1117 2351069
Eye irritation 70.80 35.09 31 5868 3481 2348705
Gait disturbance 70.60 35.09 60 5839 22485 2329701
Listeriosis 69.36 35.09 16 5883 209 2351977
Anal fistula 68.68 35.09 19 5880 533 2351653
Behcet's syndrome 68.24 35.09 15 5884 155 2352031
Peripheral swelling 68.11 35.09 53 5846 17544 2334642
Clostridium difficile infection 66.45 35.09 28 5871 2862 2349324
Lymphoma 66.06 35.09 25 5874 1929 2350257
JC virus infection 65.02 35.09 15 5884 196 2351990
Hepatic cirrhosis 65.00 35.09 26 5873 2327 2349859
Alanine aminotransferase increased 64.83 35.09 47 5852 13985 2338201
Pre-existing condition improved 64.52 35.09 18 5881 521 2351665
Herpes simplex hepatitis 64.39 35.09 12 5887 48 2352138
Asthenia 64.36 35.09 80 5819 46846 2305340
Candida infection 63.28 35.09 27 5872 2846 2349340
Acute respiratory distress syndrome 62.94 35.09 28 5871 3264 2348922
Urosepsis 62.14 35.09 24 5875 1957 2350229
Foot deformity 62.05 35.09 24 5875 1965 2350221
Joint dislocation 61.70 35.09 22 5877 1434 2350752
Hepatotoxicity 61.44 35.09 28 5871 3453 2348733
Mycobacterium abscessus infection 61.40 35.09 12 5887 65 2352121
Respiratory tract infection 60.56 35.09 29 5870 4000 2348186
Gestational hypertension 59.82 35.09 16 5883 394 2351792
Cough 59.69 35.09 65 5834 33052 2319134
Hepatic failure 59.37 35.09 32 5867 5657 2346529
Rectal cancer metastatic 59.22 35.09 11 5888 43 2352143
Meningoencephalitis viral 59.09 35.09 10 5889 19 2352167
Central nervous system lymphoma 59.08 35.09 14 5885 207 2351979
Histoplasmosis disseminated 59.01 35.09 14 5885 208 2351978
Oral candidiasis 58.78 35.09 23 5876 1942 2350244
Swelling face 58.53 35.09 38 5861 9455 2342731
Mouth ulceration 58.32 35.09 28 5871 3884 2348302
Pleural effusion 58.31 35.09 41 5858 11627 2340559
Plasmablastic lymphoma 58.25 35.09 11 5888 48 2352138
Upper limb fracture 58.03 35.09 25 5874 2698 2349488
Gastrointestinal lymphoma 57.58 35.09 9 5890 7 2352179
Liver transplant rejection 57.39 35.09 15 5884 337 2351849
Chronic kidney disease 56.96 35.09 28 5871 4090 2348096
Immunosuppressant drug level decreased 56.48 35.09 13 5886 168 2352018
Herpes simplex 56.33 35.09 19 5880 1048 2351138
Oesophageal candidiasis 56.03 35.09 17 5882 665 2351521
Large intestinal stenosis 55.98 35.09 15 5884 372 2351814
No adverse event 55.96 35.09 37 5862 9491 2342695
Loss of personal independence in daily activities 55.77 35.09 30 5869 5281 2346905
Dry mouth 55.76 35.09 35 5864 8218 2343968
Rectal haemorrhage 55.75 35.09 31 5868 5825 2346361
Thrombotic microangiopathy 55.74 35.09 20 5879 1327 2350859
Hepatitis E 55.25 35.09 13 5886 186 2352000
Skin lesion 54.57 35.09 27 5872 3998 2348188
Cytomegalovirus colitis 54.50 35.09 14 5885 293 2351893
Influenza 54.39 35.09 41 5858 12937 2339249
Inflammation 54.04 35.09 31 5868 6182 2346004
Necrosis 53.50 35.09 18 5881 985 2351201
Corynebacterium infection 53.25 35.09 11 5888 82 2352104
Hepatosplenomegaly 52.87 35.09 15 5884 462 2351724
Drug resistance 52.36 35.09 23 5876 2601 2349585
Abscess rupture 52.17 35.09 10 5889 48 2352138
Patent ductus arteriosus 51.96 35.09 16 5883 658 2351528
Lupus myocarditis 51.90 35.09 8 5891 5 2352181
Tuberculosis of central nervous system 51.83 35.09 10 5889 50 2352136
Respiratory disorder 51.75 35.09 26 5873 3978 2348208
Hepatosplenic T-cell lymphoma 51.67 35.09 10 5889 51 2352135
Ascites 51.46 35.09 29 5870 5591 2346595
Aplastic anaemia 51.31 35.09 17 5882 887 2351299
Autoimmune hepatitis 51.27 35.09 20 5879 1675 2350511
Eye disorder 50.92 35.09 24 5875 3195 2348991
Cervical dysplasia 50.85 35.09 16 5883 707 2351479
Osteoarthritis 50.83 35.09 31 5868 6915 2345271
Cytomegalovirus chorioretinitis 50.79 35.09 12 5887 175 2352011
Drug-induced liver injury 50.70 35.09 25 5874 3674 2348512
Nocardiosis 50.57 35.09 13 5886 273 2351913
Strongyloidiasis 50.54 35.09 12 5887 179 2352007
Hodgkin's disease 50.21 35.09 15 5884 556 2351630
Anterograde amnesia 50.19 35.09 11 5888 112 2352074
Renal cell carcinoma 50.13 35.09 16 5883 741 2351445
Drug ineffective for unapproved indication 49.66 35.09 23 5876 2943 2349243
Bronchopulmonary aspergillosis 49.56 35.09 17 5882 987 2351199
Drug reaction with eosinophilia and systemic symptoms 49.24 35.09 28 5871 5490 2346696
Night sweats 49.00 35.09 24 5875 3476 2348710
Anogenital warts 48.39 35.09 11 5888 134 2352052
Diarrhoea haemorrhagic 47.98 35.09 18 5881 1355 2350831
Viral infection 47.95 35.09 26 5873 4650 2347536
Brain abscess 47.93 35.09 13 5886 338 2351848
Oesophageal squamous cell carcinoma 47.90 35.09 9 5890 38 2352148
Gestational diabetes 47.80 35.09 18 5881 1369 2350817
Sinusitis 47.69 35.09 42 5857 16484 2335702
Nephrotic syndrome 47.68 35.09 17 5882 1107 2351079
Bursitis infective 47.46 35.09 10 5889 83 2352103
Nodular regenerative hyperplasia 47.46 35.09 10 5889 83 2352103
Bacteraemia 47.38 35.09 19 5880 1711 2350475
Atypical haemolytic uraemic syndrome 47.36 35.09 10 5889 84 2352102
Aplasia pure red cell 47.13 35.09 15 5884 688 2351498
Posterior reversible encephalopathy syndrome 47.10 35.09 21 5878 2459 2349727
Bone marrow toxicity 46.91 35.09 13 5886 367 2351819
Sciatica 46.89 35.09 20 5879 2105 2350081
Appendicitis 46.83 35.09 17 5882 1166 2351020
Nonalcoholic fatty liver disease 46.65 35.09 9 5890 45 2352141
Psoriatic arthropathy 46.46 35.09 24 5875 3890 2348296
Encephalitis 46.41 35.09 17 5882 1197 2350989
Hepatic fibrosis 46.23 35.09 14 5885 544 2351642
Enterococcal infection 46.16 35.09 15 5884 736 2351450
Infectious mononucleosis 45.87 35.09 13 5886 399 2351787
Extrapulmonary tuberculosis 45.55 35.09 9 5890 52 2352134
Drug level below therapeutic 45.17 35.09 13 5886 422 2351764
Immunosuppressant drug level increased 45.17 35.09 13 5886 422 2351764
Abdominal tenderness 45.04 35.09 16 5883 1031 2351155
Lupus vasculitis 44.96 35.09 8 5891 23 2352163
Haematochezia 44.93 35.09 26 5873 5269 2346917
Myositis 44.83 35.09 17 5882 1318 2350868
Acute febrile neutrophilic dermatosis 44.56 35.09 13 5886 443 2351743
Histoplasmosis 44.46 35.09 12 5887 306 2351880
Abdominal pain upper 44.43 35.09 46 5853 22054 2330132
Abscess 44.31 35.09 20 5879 2411 2349775
Dehydration 44.10 35.09 46 5853 22249 2329937
Therapeutic response unexpected 43.91 35.09 23 5876 3836 2348350
Herpes virus infection 43.89 35.09 15 5884 861 2351325
Abdominal pain lower 43.74 35.09 21 5878 2912 2349274
Hydrops foetalis 43.70 35.09 9 5890 66 2352120
Overlap syndrome 43.58 35.09 9 5890 67 2352119
Hypoxia 43.55 35.09 27 5872 6200 2345986
Nephropathy toxic 43.07 35.09 16 5883 1172 2351014
Gastroenteritis 42.89 35.09 21 5878 3039 2349147
Acute hepatic failure 42.71 35.09 20 5879 2622 2349564
Obliterative bronchiolitis 42.47 35.09 11 5888 238 2351948
Actinic keratosis 42.22 35.09 12 5887 372 2351814
Pneumothorax 42.07 35.09 19 5880 2293 2349893
Osteonecrosis 41.87 35.09 28 5871 7314 2344872
Abdominal discomfort 41.86 35.09 40 5859 17416 2334770
Transient hypogammaglobulinaemia of infancy 41.84 35.09 6 5893 0 2352186
Upper respiratory tract infection 41.67 35.09 30 5869 8821 2343365
Microsporidia infection 41.47 35.09 8 5891 40 2352146
Localised infection 41.10 35.09 20 5879 2856 2349330
Sepsis neonatal 40.85 35.09 9 5890 94 2352092
Haemodialysis 40.84 35.09 18 5881 2051 2350135
Liver disorder 40.33 35.09 26 5873 6388 2345798
Anal ulcer 40.27 35.09 9 5890 101 2352085
Neutropenic sepsis 40.05 35.09 16 5883 1426 2350760
Jaw fracture 39.70 35.09 12 5887 463 2351723
Metastatic malignant melanoma 39.40 35.09 11 5888 319 2351867
Papilloma viral infection 39.37 35.09 11 5888 320 2351866
Epstein-Barr virus associated lymphoma 39.30 35.09 8 5891 55 2352131
Myopathy 39.01 35.09 16 5883 1527 2350659
Hepatic steatosis 39.00 35.09 20 5879 3193 2348993
Foetal death 38.92 35.09 17 5882 1895 2350291
Pneumocystis jirovecii infection 38.81 35.09 10 5889 212 2351974
Pulmonary mass 38.80 35.09 17 5882 1909 2350277
Uveitis 38.40 35.09 16 5883 1589 2350597
Swelling 38.32 35.09 37 5862 16313 2335873
Malignant melanoma 38.25 35.09 17 5882 1975 2350211
Hair follicle tumour benign 38.18 35.09 7 5892 25 2352161
Chronic allograft nephropathy 38.04 35.09 9 5890 132 2352054
Sjogren's syndrome 37.93 35.09 14 5885 1007 2351179
Respiratory distress 37.80 35.09 23 5876 5106 2347080
Hypotension 37.69 35.09 51 5848 32385 2319801
Post procedural complication 37.63 35.09 19 5880 2935 2349251
Skin mass 37.61 35.09 14 5885 1031 2351155
Pericardial effusion 37.54 35.09 21 5878 3988 2348198
Agranulocytosis 37.48 35.09 20 5879 3462 2348724
Blood alkaline phosphatase increased 37.42 35.09 25 5874 6520 2345666
Laryngeal stenosis 37.29 35.09 8 5891 73 2352113
Enterococcal sepsis 37.19 35.09 9 5890 146 2352040
Enteritis 37.08 35.09 14 5885 1072 2351114
Cytomegalovirus test positive 36.94 35.09 11 5888 403 2351783
Aphthous ulcer 36.86 35.09 15 5884 1403 2350783
T-cell lymphoma 36.74 35.09 9 5890 154 2352032
Pneumatosis intestinalis 36.71 35.09 11 5888 412 2351774
Impaired healing 36.67 35.09 23 5876 5388 2346798
Dermatomyositis 36.35 35.09 11 5888 426 2351760
Tachycardia 36.34 35.09 36 5863 16373 2335813
Cellulitis 36.19 35.09 28 5871 9173 2343013
Porokeratosis 35.80 35.09 7 5892 38 2352148
Weight increased 35.34 35.09 41 5858 22296 2329890
Polyomavirus-associated nephropathy 35.33 35.09 9 5890 182 2352004
Heart transplant rejection 35.30 35.09 8 5891 96 2352090
Pregnancy 35.27 35.09 26 5873 7923 2344263
Intentional overdose 35.13 35.09 30 5869 11291 2340895
Fibrosis 35.11 35.09 11 5888 479 2351707

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug ineffective 958.35 40.48 493 4192 63308 1678788
Pyrexia 568.27 40.48 315 4370 46085 1696011
Pancytopenia 552.49 40.48 203 4482 11154 1730942
Pneumonia 493.28 40.48 287 4398 45895 1696201
Leukopenia 481.14 40.48 170 4515 8310 1733786
Drug eruption 478.52 40.48 132 4553 2794 1739302
Hepatic function abnormal 448.03 40.48 154 4531 6920 1735176
Pneumocystis jirovecii pneumonia 406.98 40.48 112 4573 2344 1739752
Kaposi's sarcoma 405.82 40.48 91 4594 776 1741320
Product use in unapproved indication 401.30 40.48 153 4532 9269 1732827
Cytomegalovirus infection 396.05 40.48 117 4568 3184 1738912
Stomatitis 386.62 40.48 129 4556 5275 1736821
Hypersensitivity 372.02 40.48 149 4536 10295 1731801
Crohn's disease 370.33 40.48 120 4565 4467 1737629
Epistaxis 364.82 40.48 138 4547 8168 1733928
Post transplant lymphoproliferative disorder 363.44 40.48 81 4604 669 1741427
Hepatosplenic T-cell lymphoma 353.78 40.48 60 4625 75 1742021
Pain in extremity 344.04 40.48 167 4518 18305 1723791
Sepsis 327.05 40.48 164 4521 19274 1722822
Diffuse large B-cell lymphoma 315.29 40.48 78 4607 1051 1741045
Squamous cell carcinoma 308.30 40.48 85 4600 1786 1740310
Urticaria 300.12 40.48 134 4551 12107 1729989
Muscle spasms 297.05 40.48 131 4554 11490 1730606
Epstein-Barr virus infection 265.77 40.48 68 4617 1057 1741039
Off label use 260.18 40.48 180 4505 38391 1703705
Basal cell carcinoma 233.31 40.48 73 4612 2410 1739686
Colitis ulcerative 231.85 40.48 73 4612 2461 1739635
Disease recurrence 230.50 40.48 73 4612 2509 1739587
Bone marrow failure 230.13 40.48 87 4598 5113 1736983
Foetal exposure during pregnancy 226.94 40.48 91 4594 6268 1735828
Multiple organ dysfunction syndrome 225.71 40.48 101 4584 9141 1732955
Premature baby 225.16 40.48 74 4611 2868 1739228
Haemophagocytic lymphohistiocytosis 220.59 40.48 62 4623 1398 1740698
Treatment failure 214.32 40.48 79 4606 4322 1737774
Nodular regenerative hyperplasia 211.55 40.48 40 4645 125 1741971
Lymphoproliferative disorder 207.01 40.48 47 4638 424 1741672
Squamous cell carcinoma of skin 202.53 40.48 56 4629 1186 1740910
Weight decreased 196.16 40.48 124 4561 22629 1719467
Kidney transplant rejection 186.25 40.48 52 4633 1142 1740954
Anaemia 185.39 40.48 132 4553 29325 1712771
Abdominal pain 179.90 40.48 115 4570 21375 1720721
Transplant rejection 170.92 40.48 50 4635 1304 1740792
Epstein-Barr virus associated lymphoproliferative disorder 159.92 40.48 36 4649 311 1741785
Lymphopenia 158.95 40.48 52 4633 1981 1740115
Progressive multifocal leukoencephalopathy 153.10 40.48 48 4637 1591 1740505
Neutropenia 150.93 40.48 97 4588 18163 1723933
Condition aggravated 149.76 40.48 102 4583 21048 1721048
Thrombocytopenia 146.96 40.48 101 4584 21148 1720948
Respiratory failure 145.02 40.48 87 4598 14418 1727678
Diarrhoea 144.89 40.48 148 4537 53704 1688392
Aspergillus infection 144.23 40.48 44 4641 1329 1740767
Candida infection 140.72 40.48 47 4638 1911 1740185
Septic shock 140.47 40.48 70 4615 8039 1734057
Renal cell carcinoma 136.00 40.48 43 4642 1465 1740631
Bronchopulmonary aspergillosis 134.40 40.48 43 4642 1523 1740573
Renal impairment 133.90 40.48 78 4607 12236 1729860
Renal failure 126.34 40.48 90 4595 19927 1722169
Lymphadenopathy 123.23 40.48 52 4633 4062 1738034
Pancreatitis acute 120.23 40.48 51 4634 4036 1738060
Pancreatitis 118.44 40.48 60 4625 7127 1734969
Herpes zoster 117.94 40.48 52 4633 4521 1737575
C-reactive protein increased 117.49 40.48 56 4629 5829 1736267
Splenomegaly 114.05 40.48 41 4644 2079 1740017
Acute febrile neutrophilic dermatosis 112.97 40.48 27 4658 310 1741786
Cytomegalovirus viraemia 112.91 40.48 30 4655 542 1741554
Human herpesvirus 8 infection 112.09 40.48 22 4663 88 1742008
Lung transplant rejection 110.73 40.48 22 4663 95 1742001
Drug intolerance 109.89 40.48 54 4631 6008 1736088
Drug reaction with eosinophilia and systemic symptoms 109.68 40.48 51 4634 5019 1737077
Immunosuppression 109.42 40.48 32 4653 832 1741264
Colitis 109.30 40.48 48 4637 4132 1737964
Hodgkin's disease 107.97 40.48 31 4654 754 1741342
Drug hypersensitivity 104.63 40.48 72 4613 15063 1727033
Arthralgia 100.93 40.48 84 4601 23360 1718736
Blood creatinine increased 100.31 40.48 68 4617 13878 1728218
Hepatitis cholestatic 100.04 40.48 33 4652 1288 1740808
Low birth weight baby 99.89 40.48 30 4655 857 1741239
Acquired gene mutation 99.53 40.48 22 4663 173 1741923
Portal hypertension 98.42 40.48 28 4657 658 1741438
JC virus infection 97.80 40.48 22 4663 189 1741907
T-cell lymphoma 95.63 40.48 22 4663 211 1741885
Transplant dysfunction 94.92 40.48 24 4661 353 1741743
Acute kidney injury 93.57 40.48 96 4589 34848 1707248
Intestinal perforation 93.47 40.48 33 4652 1586 1740510
Herpes simplex 93.28 40.48 27 4658 676 1741420
Infection 93.03 40.48 62 4623 12298 1729798
Strongyloidiasis 91.79 40.48 24 4661 406 1741690
Nausea 91.63 40.48 114 4571 51082 1691014
Vomiting 91.46 40.48 99 4586 38216 1703880
Gastrointestinal disorder 91.15 40.48 44 4641 4704 1737392
Lower respiratory tract infection 90.36 40.48 41 4644 3810 1738286
Pulmonary tuberculosis 90.34 40.48 29 4656 1037 1741059
Diabetes mellitus 89.16 40.48 49 4636 6859 1735237
B-cell lymphoma 88.76 40.48 27 4658 806 1741290
Hepatic enzyme increased 88.32 40.48 48 4637 6573 1735523
Cytomegalovirus enteritis 87.20 40.48 16 4669 40 1742056
Skin lesion 87.09 40.48 37 4648 2935 1739161
Chills 86.44 40.48 58 4627 11629 1730467
Hepatitis 86.39 40.48 43 4642 4912 1737184
Cushingoid 84.37 40.48 22 4663 368 1741728
Hepatitis B 82.52 40.48 29 4656 1374 1740722
Hepatotoxicity 82.50 40.48 36 4649 3048 1739048
Hepatosplenomegaly 82.45 40.48 24 4661 613 1741483
Pleural effusion 81.83 40.48 55 4630 11055 1731041
Vasculitis 79.25 40.48 29 4656 1546 1740550
Granulomatosis with polyangiitis 78.03 40.48 17 4668 124 1741972
Epstein-Barr virus associated lymphoma 77.95 40.48 16 4669 84 1742012
Epstein-Barr virus test positive 77.91 40.48 17 4668 125 1741971
Nocardiosis 77.48 40.48 22 4663 513 1741583
Disseminated tuberculosis 77.28 40.48 22 4663 518 1741578
Non-Hodgkin's lymphoma 77.18 40.48 25 4660 920 1741176
Pemphigus 77.10 40.48 19 4666 250 1741846
Osteoporosis 75.90 40.48 28 4657 1527 1740569
Transaminases increased 74.27 40.48 36 4649 3881 1738215
Histoplasmosis disseminated 73.17 40.48 18 4667 235 1741861
Night sweats 72.24 40.48 30 4655 2246 1739850
Chronic allograft nephropathy 71.69 40.48 17 4668 188 1741908
Haemodialysis 71.47 40.48 31 4654 2585 1739511
Mucormycosis 70.23 40.48 22 4663 725 1741371
Acute myeloid leukaemia 70.14 40.48 32 4653 3009 1739087
Therapy non-responder 68.82 40.48 40 4645 6226 1735870
Therapeutic product effect decreased 68.63 40.48 40 4645 6257 1735839
Cytomegalovirus colitis 68.48 40.48 18 4667 311 1741785
Hepatic failure 68.34 40.48 39 4646 5864 1736232
Obliterative bronchiolitis 68.20 40.48 17 4668 235 1741861
Non-cirrhotic portal hypertension 68.15 40.48 13 4672 43 1742053
Foetal growth restriction 67.90 40.48 21 4664 663 1741433
Meningitis cryptococcal 67.53 40.48 18 4667 329 1741767
Headache 66.95 40.48 80 4605 34296 1707800
Herpes zoster meningoencephalitis 66.63 40.48 13 4672 50 1742046
Complications of transplanted kidney 66.09 40.48 20 4665 586 1741510
Staphylococcal infection 65.19 40.48 35 4650 4672 1737424
Hypogammaglobulinaemia 65.04 40.48 20 4665 619 1741477
Disseminated intravascular coagulation 64.87 40.48 32 4653 3582 1738514
Lymphoma 64.59 40.48 27 4658 2055 1740041
Fatigue 63.30 40.48 95 4590 50686 1691410
Therapeutic response decreased 62.76 40.48 36 4649 5464 1736632
Malaise 61.18 40.48 71 4614 29494 1712602
Intentional product use issue 60.78 40.48 28 4657 2691 1739405
Haemoglobin decreased 60.76 40.48 55 4630 17059 1725037
Abscess 59.72 40.48 25 4660 1909 1740187
Central nervous system lesion 59.58 40.48 21 4664 1003 1741093
Viral infection 59.21 40.48 28 4657 2855 1739241
Drug resistance 59.16 40.48 29 4656 3201 1738895
Metastases to liver 59.12 40.48 26 4659 2241 1739855
Neurological symptom 59.07 40.48 19 4666 683 1741413
Squamous cell carcinoma of the tongue 58.94 40.48 12 4673 60 1742036
Dyspnoea 58.72 40.48 93 4592 51966 1690130
Hand deformity 58.67 40.48 15 4670 231 1741865
Cholestasis 58.58 40.48 30 4655 3635 1738461
Platelet count decreased 58.46 40.48 53 4632 16470 1725626
General physical health deterioration 58.41 40.48 48 4637 13070 1729026
Graft versus host disease 57.96 40.48 23 4662 1530 1740566
Clostridium difficile colitis 57.24 40.48 23 4662 1581 1740515
Ascites 56.97 40.48 34 4651 5552 1736544
Visceral leishmaniasis 56.56 40.48 13 4672 124 1741972
Heart transplant rejection 56.54 40.48 14 4671 188 1741908
Cough 55.38 40.48 55 4630 19142 1722954
Product use issue 54.99 40.48 39 4646 8532 1733564
Cryptococcosis 54.95 40.48 15 4670 301 1741795
Clostridium difficile infection 54.92 40.48 23 4662 1758 1740338
Influenza like illness 54.45 40.48 34 4651 6019 1736077
Papilloma viral infection 54.43 40.48 12 4673 93 1742003
Neuroendocrine carcinoma of the skin 54.39 40.48 13 4672 149 1741947
Drug interaction 54.28 40.48 65 4620 27893 1714203
Immunosuppressant drug level increased 53.98 40.48 17 4668 570 1741526
Cushing's syndrome 53.50 40.48 17 4668 587 1741509
Skin cancer 53.49 40.48 21 4664 1358 1740738
Liver disorder 51.56 40.48 32 4653 5604 1736492
Peritonitis 51.38 40.48 25 4660 2714 1739382
Metastases to lymph nodes 51.30 40.48 18 4667 848 1741248
Myopathy 51.21 40.48 22 4663 1791 1740305
Liver function test abnormal 51.09 40.48 32 4653 5694 1736402
Varicella zoster virus infection 50.80 40.48 13 4672 201 1741895
Lung infiltration 50.66 40.48 23 4662 2136 1739960
Joint swelling 50.48 40.48 33 4652 6320 1735776
Polyomavirus-associated nephropathy 49.90 40.48 15 4670 429 1741667
Pneumoperitoneum 49.56 40.48 14 4671 320 1741776
Extrapulmonary tuberculosis 49.46 40.48 10 4675 48 1742048
Liver transplant rejection 49.09 40.48 15 4670 454 1741642
Rash 49.01 40.48 73 4612 38620 1703476
Aplasia pure red cell 48.49 40.48 18 4667 998 1741098
Pulmonary nocardiosis 48.36 40.48 9 4676 25 1742071
Rash erythematous 48.04 40.48 27 4658 3938 1738158
Hepatitis C 47.93 40.48 24 4661 2772 1739324
Diarrhoea haemorrhagic 47.76 40.48 18 4667 1041 1741055
Asthenia 47.66 40.48 68 4617 34602 1707494
Pneumatosis intestinalis 47.51 40.48 15 4670 507 1741589
Red blood cell sedimentation rate increased 47.21 40.48 18 4667 1075 1741021
Chronic myeloid leukaemia 47.13 40.48 16 4669 682 1741414
Myelodysplastic syndrome 47.06 40.48 25 4660 3264 1738832
Infection reactivation 46.94 40.48 11 4674 115 1741981
Cow pox 45.97 40.48 7 4678 1 1742095
Actinic keratosis 45.88 40.48 15 4670 568 1741528
Lymphadenitis 45.78 40.48 13 4672 303 1741793
Mycobacterium chelonae infection 45.41 40.48 10 4675 77 1742019
Mycobacterium avium complex infection 44.91 40.48 13 4672 325 1741771
Lung abscess 44.81 40.48 14 4671 457 1741639
Functional gastrointestinal disorder 44.72 40.48 13 4672 330 1741766
Epstein Barr virus positive mucocutaneous ulcer 44.72 40.48 9 4676 42 1742054
Skin necrosis 44.53 40.48 16 4669 808 1741288
Escherichia sepsis 44.30 40.48 15 4670 634 1741462
Interstitial lung disease 44.24 40.48 36 4649 9660 1732436
Lymphocyte count decreased 44.07 40.48 21 4664 2177 1739919
Respiratory tract infection fungal 42.99 40.48 10 4675 101 1741995
Cellulitis 42.80 40.48 30 4655 6438 1735658
Lung neoplasm 42.44 40.48 15 4670 722 1741374
Nephropathy toxic 42.38 40.48 19 4666 1713 1740383
Frequent bowel movements 42.00 40.48 18 4667 1456 1740640
Neutropenic sepsis 41.79 40.48 18 4667 1474 1740622
Large intestinal stenosis 41.65 40.48 12 4673 295 1741801
Escherichia infection 41.62 40.48 16 4669 977 1741119
Ileal stenosis 41.61 40.48 12 4673 296 1741800
Intestinal fistula 41.52 40.48 11 4674 196 1741900
Opportunistic infection 40.58 40.48 12 4673 324 1741772
Fungal infection 40.49 40.48 20 4665 2242 1739854

Pharmacologic Action:

SourceCodeDescription
ATC L04AX01 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
IMMUNOSUPPRESSANTS
IMMUNOSUPPRESSANTS
Other immunosuppressants
FDA MoA N0000000233 Nucleic Acid Synthesis Inhibitors
FDA Chemical/Ingredient N0000175459 Nucleoside Analog
FDA EPC N0000175712 Purine Antimetabolite
FDA Chemical/Ingredient N0000008065 Purines
MeSH PA D000963 Antimetabolites
MeSH PA D000964 Antimetabolites, Antineoplastic
MeSH PA D000970 Antineoplastic Agents
MeSH PA D018501 Antirheumatic Agents
MeSH PA D007155 Immunologic Factors
MeSH PA D007166 Immunosuppressive Agents
MeSH PA D009676 Noxae

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Rheumatoid arthritis indication 69896004 DOID:7148
Prevention of Kidney Transplant Rejection indication
Polymyositis off-label use 31384009
Crohn's disease off-label use 34000006
Systemic lupus erythematosus off-label use 55464009 DOID:9074
Ulcerative colitis off-label use 64766004 DOID:8577
Pemphigus off-label use 65172003 DOID:9182
Autoimmune hepatitis off-label use 408335007
Prevention of Liver Transplant Rejection off-label use
Prevention of Cardiac Transplant Rejection off-label use
Prevention of Lung Transplant Rejection off-label use
Systemic Dermatomyositis off-label use
Mycosis contraindication 3218000 DOID:1564
Viral disease contraindication 34014006 DOID:934
Hepatic vein thrombosis contraindication 38739001 DOID:11512
Bacterial infectious disease contraindication 87628006
Malignant lymphoma contraindication 118600007 DOID:0060058
Liver function tests abnormal contraindication 166603001
Acute pancreatitis contraindication 197456007 DOID:2913
Impaired renal function disorder contraindication 197663003
Anemia contraindication 271737000 DOID:2355
Pregnancy, function contraindication 289908002
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Bone marrow depression contraindication 307762000
Hepatosplenic T-cell lymphoma contraindication 445406001
Protozoal Infection contraindication
Thiopurine S-Methyltransferase Deficiency contraindication
Severe Leukopenia contraindication

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.28 acidic
pKa2 3.24 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Thiopurine S-methyltransferase Enzyme WOMBAT-PK
Ras-related C3 botulinum toxin substrate 1 Unclassified WOMBAT-PK
Multidrug resistance-associated protein 4 Transporter WOMBAT-PK
Multidrug resistance-associated protein 5 Transporter WOMBAT-PK
ATP-binding cassette sub-family G member 2 Transporter WOMBAT-PK
DNA DNA OTHER DRUG LABEL SCIENTIFIC LITERATURE
RNA RNA OTHER DRUG LABEL SCIENTIFIC LITERATURE

External reference:

IDSource
D001379 MESH_DESCRIPTOR_UI
4018766 VUID
N0000147069 NUI
C0004482 UMLSCUI
D00238 KEGG_DRUG
111165009 SNOMEDCT_US
4018766 VANDF
1256 RXNORM
6041 MMSL
d00024 MMSL
372574004 SNOMEDCT_US
4234 MMSL
003419 NDDF
AM94R510MS UNII
55774-33-9 SECONDARY_CAS_RN
CHEMBL1542 ChEMBL_ID
DB00993 DRUGBANK_ID
CHEMBL1200400 ChEMBL_ID
1291 INN_ID
7120 IUPHAR_LIGAND_ID
2265 PUBCHEM_CID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Azathioprine Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0143-9566 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 100 mg INTRAVENOUS ANDA 13 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 0378-1005 TABLET 50 mg ORAL ANDA 13 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 0615-7568 TABLET 50 mg ORAL ANDA 11 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 21695-484 TABLET 50 mg ORAL ANDA 14 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 33261-758 TABLET 50 mg ORAL ANDA 14 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 43353-745 TABLET 50 mg ORAL ANDA 14 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 51079-620 TABLET 50 mg ORAL ANDA 13 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 51407-182 TABLET 50 mg ORAL ANDA 13 sections
IMURAN HUMAN PRESCRIPTION DRUG LABEL 1 54766-590 TABLET 50 mg ORAL NDA 14 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 54868-5310 TABLET 50 mg ORAL ANDA 14 sections
AZATHIOPRINE HUMAN PRESCRIPTION DRUG LABEL 1 60219-1076 TABLET 50 mg ORAL ANDA 13 sections
IMURAN HUMAN PRESCRIPTION DRUG LABEL 1 65483-590 TABLET 50 mg ORAL NDA 14 sections
Azasan HUMAN PRESCRIPTION DRUG LABEL 1 65649-231 TABLET 75 mg ORAL ANDA 13 sections
Azasan HUMAN PRESCRIPTION DRUG LABEL 1 65649-241 TABLET 100 mg ORAL ANDA 13 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 65841-602 TABLET 50 mg ORAL ANDA 14 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 67877-492 TABLET 25 mg ORAL ANDA 13 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 67877-493 TABLET 50 mg ORAL ANDA 13 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 67877-494 TABLET 75 mg ORAL ANDA 13 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 67877-495 TABLET 100 mg ORAL ANDA 13 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 68084-229 TABLET 50 mg ORAL ANDA 14 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 68382-003 TABLET 50 1 ORAL ANDA 14 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 68382-118 TABLET 25 1 ORAL ANDA 14 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 68382-119 TABLET 75 1 ORAL ANDA 14 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 68382-120 TABLET 100 1 ORAL ANDA 14 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 68462-502 TABLET 50 mg ORAL ANDA 13 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 70771-1139 TABLET 25 1 ORAL ANDA 1 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 70771-1140 TABLET 75 1 ORAL ANDA 1 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 70771-1141 TABLET 100 1 ORAL ANDA 1 sections
AZATHIOPRINE HUMAN PRESCRIPTION DRUG LABEL 1 71610-124 TABLET 50 mg ORAL ANDA 14 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 71610-306 TABLET 50 mg ORAL ANDA 14 sections