azathioprine ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
269 446-86-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • BW 57-322
  • azathioprine sulfate
  • azathioprine
  • azamune
  • azanin
  • azathioprin
  • azathropine
  • azothioprine
  • azathioprine sodium
Azathioprine is an inactive pro-drug of 6-mercaptopurine (6-MP), which acts as a purine antagonist but requires cellular uptake and intracellular anabolism to thioguanine nucleotides (TGNs) for immunosuppression. TGNs and other metabolites (e.g. 6-methylmercaptopurine ribonucleotides) inhibit de novo purine synthesis and purine nucleotide interconversions. The TGNs are also incorporated into nucleic acids and this contributes to the immunosuppressive effects of the medicinal product. Other potential mechanisms of azathioprine include the inhibition of many pathways in nucleic acid biosynthesis, hence preventing proliferation and activity of cells involved in the immune response (B and T lymphocytes). Because of these mechanisms, the therapeutic effect of azathioprine may be evident only after several weeks or months of treatment. Unlike 6-MP, the activity of the azathioprine metabolite 1-methyl-4-nitro-5-thioimidazole has not been clearly determined. However, compared with 6-MP it appears to modify the activity of azathioprine in several systems. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed)
  • Molecular weight: 277.26
  • Formula: C9H7N7O2S
  • CLOGP: 0.51
  • LIPINSKI: 0
  • HAC: 9
  • HDO: 1
  • TPSA: 115.42
  • ALOGS: -2.41
  • ROTB: 3

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.15 g O
0.15 g P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 10 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 1 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 18.03 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 60 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

DateAgencyCompanyOrphan
March 20, 1968 FDA PROMETHEUS LABS
Feb. 21, 2019 PMDA ASPEN JAPAN K.K.; MITSUBISHI TANABE PHARMA CORPORATION

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Off label use 561.85 9.62 2357 113539 472069 50017159
Drug ineffective 536.53 9.62 3447 112449 815886 49673342
Blood iron abnormal 527.72 9.62 220 115676 3106 50486122
Exposure during pregnancy 509.36 9.62 958 114938 120057 50369171
Drug intolerance 364.33 9.62 1216 114680 217888 50271340
Colitis ulcerative 337.75 9.62 292 115604 16562 50472666
Treatment failure 314.63 9.62 855 115041 136782 50352446
Premature delivery 255.91 9.62 293 115603 23370 50465858
Cytomegalovirus infection 240.66 9.62 249 115647 17713 50471515
Death 227.62 9.62 246 115650 325133 50164095
Product use in unapproved indication 219.58 9.62 673 115223 115146 50374082
Intestinal stenosis 219.23 9.62 110 115786 2430 50486798
Lupus-like syndrome 195.34 9.62 167 115729 9324 50479904
Cushingoid 194.90 9.62 144 115752 6501 50482727
Fall 192.09 9.62 294 115602 334638 50154590
Condition aggravated 184.24 9.62 1237 114659 295821 50193407
Fistula 178.17 9.62 149 115747 8069 50481159
Bone erosion 176.71 9.62 173 115723 11514 50477714
Demyelination 170.95 9.62 128 115768 5898 50483330
SLE arthritis 165.12 9.62 60 115836 570 50488658
Anal fistula 163.97 9.62 93 115803 2649 50486579
Ileal stenosis 161.06 9.62 75 115821 1397 50487831
Fatigue 160.34 9.62 959 114937 706642 49782586
Drug level below therapeutic 159.28 9.62 102 115794 3638 50485590
Rheumatoid arthritis 152.63 9.62 887 115009 201663 50287565
Premature labour 151.76 9.62 158 115738 11318 50477910
Post transplant lymphoproliferative disorder 150.78 9.62 103 115793 4101 50485127
Therapeutic response decreased 144.24 9.62 328 115568 46903 50442325
Therapeutic product effect incomplete 143.81 9.62 499 115397 91016 50398212
Disease recurrence 140.07 9.62 200 115696 19881 50469347
Frequent bowel movements 139.88 9.62 166 115730 13752 50475476
Crohn's disease 139.78 9.62 103 115793 4630 50484598
Proteinuria 139.57 9.62 181 115715 16416 50472812
Cholestasis of pregnancy 137.48 9.62 62 115834 1069 50488159
Elbow deformity 128.44 9.62 63 115833 1323 50487905
Maternal exposure during pregnancy 127.05 9.62 710 115186 159068 50330160
Intentional product use issue 126.61 9.62 426 115470 76492 50412736
Faecal calprotectin increased 125.93 9.62 72 115824 2083 50487145
Epstein-Barr virus infection 125.74 9.62 114 115782 6883 50482345
Glossodynia 121.89 9.62 56 115840 115513 50373715
Large intestinal stenosis 121.11 9.62 65 115831 1657 50487571
Intestinal resection 119.66 9.62 72 115824 2295 50486933
Hyponatraemia 119.13 9.62 36 115860 96103 50393125
Vasculitis 116.74 9.62 152 115744 13839 50475389
Abortion spontaneous 116.51 9.62 280 115616 41492 50447736
Transplant rejection 115.92 9.62 126 115770 9483 50479745
Confusional state 114.49 9.62 155 115741 185773 50303455
Toxicity to various agents 112.78 9.62 196 115700 212303 50276925
Impaired gastric emptying 111.65 9.62 118 115778 8600 50480628
Product dose omission issue 109.46 9.62 157 115739 183681 50305547
Pre-eclampsia 108.61 9.62 112 115784 7932 50481296
Malignant neoplasm progression 108.35 9.62 14 115882 68110 50421118
Arthritis 107.26 9.62 438 115458 86283 50402945
Somnolence 105.05 9.62 120 115776 154865 50334363
Pain 104.87 9.62 837 115059 578066 49911162
Diffuse large B-cell lymphoma 103.22 9.62 93 115803 5569 50483659
Kidney transplant rejection 102.78 9.62 80 115816 3907 50485321
Anal abscess 101.95 9.62 78 115818 3713 50485515
Haematochezia 98.26 9.62 255 115641 39627 50449601
Haemophagocytic lymphohistiocytosis 96.88 9.62 109 115787 8524 50480704
Hepatic cirrhosis 95.63 9.62 156 115740 17421 50471807
Ankylosing spondylitis 93.58 9.62 98 115798 7067 50482161
Abscess 93.50 9.62 138 115758 14134 50475094
Pemphigus 91.68 9.62 84 115812 120082 50369146
Product use issue 91.51 9.62 621 115275 148854 50340374
Drug abuse 91.19 9.62 14 115882 59832 50429396
Lupus nephritis 89.96 9.62 60 115836 2295 50486933
Drug hypersensitivity 89.90 9.62 924 114972 250086 50239142
Abdominal pain 89.13 9.62 879 115017 235349 50253879
Red blood cell sedimentation rate increased 88.36 9.62 203 115693 29213 50460015
Pancreatitis 87.61 9.62 255 115641 42359 50446869
Therapeutic product effect decreased 87.35 9.62 572 115324 135478 50353750
Inflammation 86.48 9.62 307 115589 56605 50432623
Atrial fibrillation 86.44 9.62 64 115832 101681 50387547
Antinuclear antibody positive 85.90 9.62 88 115808 6184 50483044
Overdose 85.67 9.62 62 115834 99665 50389563
Joint dislocation 84.78 9.62 122 115774 12211 50477017
Electrocardiogram QT prolonged 84.13 9.62 10 115886 51876 50437352
Exostosis 84.13 9.62 118 115778 11535 50477693
Constipation 83.26 9.62 189 115707 185519 50303709
Hypotension 81.42 9.62 272 115624 235197 50254031
Cardiac failure congestive 81.32 9.62 46 115850 84336 50404892
Cytomegalovirus viraemia 81.26 9.62 75 115821 4634 50484594
Cerebrovascular accident 81.15 9.62 59 115837 94621 50394607
Anaphylactic reaction 80.78 9.62 290 115606 53765 50435463
Lung transplant rejection 80.49 9.62 38 115858 731 50488497
Basal cell carcinoma 80.12 9.62 170 115726 23186 50466042
Pancytopenia 79.51 9.62 392 115504 83638 50405590
Swelling 78.74 9.62 219 115677 200653 50288575
Osteoporosis 78.68 9.62 254 115642 44625 50444603
Pleuritic pain 78.36 9.62 85 115811 6381 50482847
Normal newborn 77.69 9.62 86 115810 6605 50482623
Rheumatoid nodule 77.53 9.62 119 115777 12616 50476612
Gestational hypertension 75.00 9.62 52 115844 2121 50487107
Disseminated tuberculosis 74.27 9.62 55 115841 2491 50486737
Squamous cell carcinoma 73.99 9.62 90 115806 7649 50481579
Hepatosplenic T-cell lymphoma 73.92 9.62 33 115863 555 50488673
Diarrhoea haemorrhagic 72.96 9.62 89 115807 7586 50481642
Tremor 72.51 9.62 94 115802 114809 50374419
Joint stiffness 71.81 9.62 191 115705 30117 50459111
Dizziness 70.55 9.62 484 115412 345885 50143343
Arthralgia 70.54 9.62 1402 114494 437300 50051928
Leukopenia 70.39 9.62 324 115572 67204 50422024
Pneumocystis jirovecii pneumonia 70.30 9.62 123 115773 14540 50474688
Asthenia 69.41 9.62 437 115459 318605 50170623
Epstein-Barr virus associated lymphoproliferative disorder 69.30 9.62 45 115851 1644 50487584
Clostridium difficile infection 69.29 9.62 169 115727 25270 50463958
Granulomatosis with polyangiitis 69.09 9.62 46 115850 1754 50487474
Synovial fluid analysis 68.09 9.62 44 115852 1594 50487634
Stomatitis 68.06 9.62 79 115817 101265 50387963
C-reactive protein increased 67.86 9.62 317 115579 66157 50423071
Hypokalaemia 67.71 9.62 61 115835 87931 50401297
Hand deformity 67.41 9.62 78 115818 100121 50389107
Intestinal obstruction 67.37 9.62 171 115725 26212 50463016
Premature baby 67.03 9.62 137 115759 18200 50471028
Hair follicle tumour benign 66.14 9.62 27 115869 360 50488868
Contusion 65.55 9.62 97 115799 112086 50377142
Abdominal discomfort 65.01 9.62 291 115605 231350 50257878
Scleritis 64.81 9.62 56 115840 3171 50486057
Immunosuppressant drug level decreased 64.27 9.62 34 115862 841 50488387
Progressive multifocal leukoencephalopathy 64.12 9.62 103 115793 11354 50477874
Gastrointestinal inflammation 63.83 9.62 65 115831 4535 50484693
Cardio-respiratory arrest 63.53 9.62 22 115874 53870 50435358
Liver function test increased 63.35 9.62 164 115732 25442 50463786
Tenosynovitis stenosans 62.54 9.62 47 115849 2177 50487051
Loss of consciousness 62.17 9.62 89 115807 104264 50384964
Syncope 61.22 9.62 88 115808 102914 50386314
Anti-neutrophil cytoplasmic antibody positive vasculitis 60.74 9.62 47 115849 2275 50486953
Colectomy 60.44 9.62 45 115851 2055 50487173
Febrile neutropenia 59.48 9.62 82 115814 97585 50391643
Blood pressure fluctuation 59.43 9.62 199 115697 35624 50453604
Gastrointestinal lymphoma 59.23 9.62 16 115880 48 50489180
Hypogammaglobulinaemia 58.96 9.62 69 115827 5630 50483598
Insomnia 58.36 9.62 205 115691 174660 50314568
Discomfort 58.31 9.62 99 115797 108281 50380947
Muscle injury 58.11 9.62 8 115888 37103 50452125
Erythema nodosum 57.55 9.62 57 115839 3846 50485382
Intentional overdose 57.50 9.62 36 115860 62468 50426760
Histoplasmosis disseminated 57.07 9.62 36 115860 1250 50487978
Autoimmune hepatitis 57.07 9.62 78 115818 7441 50481787
Diabetes mellitus 56.95 9.62 243 115653 48790 50440438
Wound 56.59 9.62 97 115799 105697 50383531
Decreased appetite 56.00 9.62 253 115643 200670 50288558
Anxiety 54.84 9.62 215 115681 177391 50311837
Lymphoproliferative disorder 53.92 9.62 48 115848 2829 50486399
Pulmonary mass 53.89 9.62 127 115769 18578 50470650
Neutrophil count decreased 53.89 9.62 19 115877 46007 50443221
Caesarean section 53.83 9.62 114 115782 15525 50473703
Overlap syndrome 53.05 9.62 27 115869 615 50488613
Lymphopenia 52.77 9.62 113 115783 15508 50473720
Dyspnoea 52.76 9.62 910 114986 546698 49942530
Ulcer 52.69 9.62 132 115764 20068 50469160
Sedation 51.92 9.62 5 115891 30605 50458623
Pulmonary tuberculosis 51.48 9.62 56 115840 4217 50485011
Lupus vasculitis 50.77 9.62 24 115872 463 50488765
Osteonecrosis 50.43 9.62 139 115757 22378 50466850
Central nervous system lymphoma 50.27 9.62 34 115862 1331 50487897
Hallucination 50.12 9.62 22 115874 46635 50442593
Retinitis 48.94 9.62 38 115858 1849 50487379
Tuberculosis 48.88 9.62 85 115811 9998 50479230
Foot deformity 48.51 9.62 124 115772 19086 50470142
Drug level decreased 48.42 9.62 67 115829 6466 50482762
Premature separation of placenta 48.39 9.62 36 115860 1642 50487586
C-reactive protein abnormal 48.38 9.62 157 115739 27652 50461576
Inappropriate schedule of product administration 47.89 9.62 305 115591 71526 50417702
Balance disorder 47.41 9.62 55 115841 70535 50418693
Interstitial lung disease 47.41 9.62 244 115652 52932 50436296
Cardiac arrest 47.25 9.62 74 115822 83577 50405651
Therapeutic product effect variable 47.09 9.62 30 115866 1060 50488168
Irritable bowel syndrome 46.81 9.62 30 115866 51411 50437817
B-cell lymphoma 46.64 9.62 45 115851 2940 50486288
Seizure 46.53 9.62 128 115768 117746 50371482
Agitation 46.08 9.62 33 115863 53351 50435877
Injection site swelling 45.98 9.62 19 115877 41754 50447474
Listeriosis 45.50 9.62 32 115864 1336 50487892
Immunosuppressant drug level increased 45.43 9.62 45 115851 3037 50486191
Intestinal fistula 45.20 9.62 26 115870 761 50488467
Duodenal ulcer perforation 45.19 9.62 24 115872 45587 50443641
Anal fissure 45.14 9.62 45 115851 3060 50486168
Angiocentric lymphoma 44.83 9.62 23 115873 533 50488695
Platelet count decreased 44.70 9.62 103 115793 100623 50388605
Histoplasmosis 44.70 9.62 35 115861 1724 50487504
Epstein-Barr virus test positive 44.64 9.62 23 115873 538 50488690
Folliculitis 44.56 9.62 17 115879 39208 50450020
Papilloma viral infection 44.46 9.62 31 115865 1276 50487952
Female genital tract fistula 44.09 9.62 48 115848 3618 50485610
Cytomegalovirus colitis 43.98 9.62 36 115860 1891 50487337
Joint swelling 43.78 9.62 797 115099 244489 50244739
Depressed level of consciousness 43.69 9.62 33 115863 51920 50437308
Chronic allograft nephropathy 43.60 9.62 24 115872 644 50488584
Depression 43.31 9.62 213 115683 165210 50324018
Blood glucose increased 43.30 9.62 60 115836 71264 50417964
Renal impairment 43.10 9.62 309 115587 75352 50413876
Impaired work ability 43.04 9.62 96 115800 13544 50475684
Nicotinic acid deficiency 43.03 9.62 12 115884 42 50489186
Suicidal ideation 41.88 9.62 39 115857 55346 50433882
Neoplasm progression 41.82 9.62 8 115888 29149 50460079
Premature rupture of membranes 41.74 9.62 52 115844 4528 50484700
Injection site erythema 41.65 9.62 67 115829 74869 50414359
Back pain 41.54 9.62 314 115582 219716 50269512
Squamous cell carcinoma of skin 41.25 9.62 55 115841 5123 50484105
Mycobacterial infection 41.09 9.62 32 115864 1564 50487664
Phospholipidosis 40.83 9.62 12 115884 53 50489175
Coma 40.76 9.62 42 115854 56837 50432391
Blister 40.67 9.62 84 115812 85334 50403894
Product label confusion 40.42 9.62 21 115875 500 50488728
Hyperkalaemia 39.86 9.62 31 115865 48058 50441170
Small intestinal obstruction 39.83 9.62 103 115793 15965 50473263
Foetal death 39.71 9.62 69 115827 8111 50481117
Fungal endocarditis 39.42 9.62 16 115880 210 50489018
Bradycardia 39.31 9.62 54 115842 64372 50424856
Muscle fatigue 39.29 9.62 36 115860 2203 50487025
Cholangitis sclerosing 39.14 9.62 28 115868 1201 50488027
Foetal growth restriction 39.04 9.62 61 115835 6566 50482662
Pulmonary fibrosis 38.99 9.62 134 115762 24303 50464925
Feeling abnormal 38.66 9.62 152 115744 125340 50363888
Orthostatic hypotension 38.43 9.62 10 115886 29471 50459757
Epicondylitis 38.08 9.62 33 115863 1876 50487352
Hypoglycaemia 37.90 9.62 40 115856 53541 50435687
Subcutaneous abscess 37.59 9.62 51 115845 4831 50484397
Helicobacter infection 37.58 9.62 35 115861 49667 50439561
Wrong technique in product usage process 37.55 9.62 43 115853 55467 50433761
Clear cell renal cell carcinoma 37.38 9.62 27 115869 1176 50488052
Low birth weight baby 37.28 9.62 56 115840 5825 50483403
Dehydration 37.25 9.62 201 115695 152248 50336980
Bone pain 37.22 9.62 32 115864 47197 50442031
Serotonin syndrome 37.14 9.62 6 115890 24707 50464521
Episcleritis 37.00 9.62 23 115873 778 50488450
Full blood count decreased 36.99 9.62 4 115892 22342 50466886
Injection site inflammation 36.87 9.62 41 115855 3164 50486064
Musculoskeletal stiffness 36.81 9.62 453 115443 128028 50361200
Bronchiectasis 36.60 9.62 76 115820 10207 50479021
Live birth 36.46 9.62 101 115795 16307 50472921
Ileostomy 36.41 9.62 26 115870 1112 50488116
Metabolic acidosis 36.21 9.62 22 115874 38803 50450425
Intentional self-injury 36.14 9.62 5 115891 23107 50466121
Antiphospholipid syndrome 36.01 9.62 29 115867 1488 50487740
Respiratory arrest 35.80 9.62 12 115884 29997 50459231
Proctitis 35.80 9.62 32 115864 1896 50487332
Pneumonia cytomegaloviral 35.61 9.62 32 115864 1909 50487319
Pregnancy 35.44 9.62 148 115748 29429 50459799
Bone marrow failure 35.29 9.62 141 115755 27483 50461745
Panniculitis 35.27 9.62 67 115829 8436 50480792
Intentional product misuse 35.23 9.62 33 115863 46701 50442527
Immunosuppression 35.21 9.62 62 115834 7364 50481864
Intestinal fibrosis 35.18 9.62 13 115883 130 50489098
Disseminated cytomegaloviral infection 35.18 9.62 14 115882 174 50489054
Aphthous ulcer 35.04 9.62 76 115820 10521 50478707
Crepitations 34.92 9.62 56 115840 6163 50483065
Plasmablastic lymphoma 34.89 9.62 14 115882 178 50489050
Palmar-plantar erythrodysaesthesia syndrome 34.85 9.62 3 115893 20095 50469133
Abdominal adhesions 34.48 9.62 37 115859 2743 50486485
Mycobacterium abscessus infection 34.45 9.62 19 115877 512 50488716
Inflammatory bowel disease 34.42 9.62 41 115855 3409 50485819
White blood cell count decreased 34.30 9.62 144 115752 116578 50372650
Injection site bruising 34.06 9.62 21 115875 36747 50452481
Impaired healing 33.75 9.62 68 115828 69718 50419510
Drug specific antibody present 33.56 9.62 40 115856 3328 50485900
Chronic obstructive pulmonary disease 33.40 9.62 44 115852 53391 50435837
Drug ineffective for unapproved indication 33.35 9.62 116 115780 21165 50468063
Nodular regenerative hyperplasia 33.34 9.62 15 115881 257 50488971
Secondary immunodeficiency 33.17 9.62 25 115871 1163 50488065
Liver transplant rejection 33.15 9.62 26 115870 1284 50487944
Dermatomyositis 32.68 9.62 32 115864 2129 50487099
Neuropathy peripheral 32.54 9.62 113 115783 96644 50392584
Colitis 32.42 9.62 174 115722 38355 50450873
Foetal exposure during pregnancy 32.08 9.62 136 115760 27223 50462005
Nausea 31.95 9.62 1307 114589 704091 49785137
Multiple sclerosis relapse 31.61 9.62 31 115865 42933 50446295
Natural killer-cell leukaemia 31.61 9.62 11 115885 91 50489137
Heart transplant rejection 31.54 9.62 17 115879 437 50488791
Enterocutaneous fistula 31.05 9.62 24 115872 1160 50488068
Uveitis 31.04 9.62 67 115829 9243 50479985
Cervical dysplasia 30.97 9.62 35 115861 2750 50486478
Suicide attempt 30.92 9.62 44 115852 51688 50437540
Pyoderma gangrenosum 30.50 9.62 35 115861 2796 50486432
Hyperhidrosis 30.37 9.62 104 115792 89322 50399906
Mycobacterium avium complex infection 30.21 9.62 33 115863 2497 50486731
Coombs positive haemolytic anaemia 30.20 9.62 15 115881 324 50488904
Restlessness 30.14 9.62 10 115886 25163 50464065
Renal mass 30.13 9.62 29 115867 1889 50487339
Red blood cell sedimentation rate abnormal 30.00 9.62 94 115802 16249 50472979
Drug withdrawal syndrome 29.97 9.62 10 115886 25071 50464157
Trichodysplasia spinulosa 29.94 9.62 17 115879 485 50488743
Myositis 29.93 9.62 60 115836 7860 50481368
Eye infection toxoplasmal 29.81 9.62 14 115882 266 50488962
Accidental exposure to product 29.72 9.62 8 115888 23049 50466179
Bronchitis 29.68 9.62 130 115766 104029 50385199
Drug tolerance 29.59 9.62 46 115850 4930 50484298
Meningitis cryptococcal 29.57 9.62 23 115873 1122 50488106
Jaw fracture 29.37 9.62 32 115864 2414 50486814
Scleroderma renal crisis 29.25 9.62 14 115882 278 50488950
Rhegmatogenous retinal detachment 29.25 9.62 10 115886 78 50489150
Chorioretinopathy 29.06 9.62 20 115876 806 50488422
Adverse reaction 28.87 9.62 62 115834 8524 50480704
Device dislocation 28.68 9.62 7 115889 21539 50467689
Synovial cyst 28.65 9.62 60 115836 8106 50481122
Hepatic fibrosis 28.62 9.62 36 115860 3166 50486062
Dyskinesia 28.58 9.62 14 115882 27847 50461381
Acute kidney injury 28.44 9.62 360 115536 227698 50261530
Fluid retention 28.41 9.62 45 115851 50604 50438624
Complications of bone marrow transplant 28.39 9.62 16 115880 450 50488778
Lactic acidosis 28.29 9.62 21 115875 33334 50455894
Extrapulmonary tuberculosis 28.28 9.62 14 115882 300 50488928
Rectal cancer metastatic 28.17 9.62 13 115883 237 50488991
Ganglioneuroma 28.06 9.62 11 115885 131 50489097
Myelosuppression 27.88 9.62 81 115815 13436 50475792
Klebsiella infection 27.78 9.62 55 115841 7139 50482089
Abscess intestinal 27.62 9.62 24 115872 1369 50487859
Laryngeal disorder 27.59 9.62 20 115876 876 50488352
Anogenital warts 27.57 9.62 15 115881 393 50488835
Salmonellosis 27.55 9.62 20 115876 878 50488350
Aspergillus infection 27.38 9.62 53 115843 6768 50482460
Varicella zoster virus infection 27.20 9.62 31 115865 2458 50486770
Neoplasm malignant 27.12 9.62 117 115779 23598 50465630
Rectal abscess 27.06 9.62 21 115875 1021 50488207
Nephrotic syndrome 26.85 9.62 43 115853 4727 50484501
Antinuclear antibody negative 26.76 9.62 12 115884 204 50489024
Abdominal abscess 26.60 9.62 39 115857 3969 50485259
Encephalopathy 26.37 9.62 23 115873 33688 50455540
Kaposi's sarcoma 26.27 9.62 11 115885 157 50489071
Therapeutic reaction time decreased 26.22 9.62 23 115873 1329 50487899
Plasma cell myeloma 26.20 9.62 20 115876 31302 50457926
Nasopharyngitis 26.17 9.62 299 115597 192628 50296600
Strongyloidiasis 26.06 9.62 19 115877 840 50488388
Injury 26.02 9.62 45 115851 48880 50440348
Eosinophilic granulomatosis with polyangiitis 25.99 9.62 27 115869 1928 50487300
Wrist deformity 25.90 9.62 26 115870 1783 50487445
Tractional retinal detachment 25.78 9.62 8 115888 44 50489184
Thiopurine methyltransferase decreased 25.75 9.62 13 115883 291 50488937
Mental status changes 25.74 9.62 27 115869 36245 50452983
Urinary retention 25.62 9.62 14 115882 26176 50463052
Somatic delusion 25.51 9.62 16 115880 550 50488678
Medication error 25.48 9.62 27 115869 36077 50453151
Tuberculosis of central nervous system 25.47 9.62 13 115883 298 50488930
Rectal discharge 25.45 9.62 15 115881 460 50488768
Meningoencephalitis viral 25.43 9.62 13 115883 299 50488929
Congenital osteodystrophy 25.21 9.62 7 115889 24 50489204
Blood calcium decreased 25.19 9.62 8 115888 20698 50468530
Sleep disorder due to general medical condition, insomnia type 25.15 9.62 21 115875 31426 50457802
Serum sickness 25.11 9.62 30 115866 2502 50486726
Drug tolerance decreased 25.10 9.62 61 115835 9099 50480129
Sleep disorder 25.07 9.62 59 115837 57224 50432004
Joint effusion 24.93 9.62 76 115820 12945 50476283
Cardiac failure 24.77 9.62 90 115806 75950 50413278
Hypomagnesaemia 24.74 9.62 11 115885 23145 50466083
Headache 24.72 9.62 930 114966 505605 49983623
Herpes simplex hepatitis 24.63 9.62 13 115883 320 50488908
Abscess rupture 24.59 9.62 12 115884 249 50488979
Intestinal mucosal hypertrophy 24.48 9.62 11 115885 188 50489040
Pneumonia aspiration 24.43 9.62 21 115875 30983 50458245
Renal transplant failure 24.34 9.62 16 115880 597 50488631
Cardiac disorder 24.28 9.62 38 115858 42941 50446287
Product quality issue 24.20 9.62 21 115875 30837 50458391
Antisynthetase syndrome 24.14 9.62 8 115888 56 50489172
Ileectomy 24.12 9.62 10 115886 139 50489089
Colectomy total 24.06 9.62 10 115886 140 50489088
Infectious mononucleosis 23.95 9.62 24 115872 1642 50487586
Bursitis infective 23.95 9.62 21 115875 1213 50488015
Glomerulosclerosis 23.88 9.62 13 115883 341 50488887
Unresponsive to stimuli 23.80 9.62 21 115875 30588 50458640
Flank pain 23.68 9.62 75 115821 13040 50476188
Sopor 23.62 9.62 8 115888 19871 50469357
Injection site pain 23.60 9.62 153 115743 110871 50378357
Lipase increased 23.53 9.62 57 115839 8484 50480744
Varicella 23.38 9.62 24 115872 1690 50487538
Dysgeusia 23.35 9.62 33 115863 38883 50450345
Abdominal pain upper 23.15 9.62 243 115653 159066 50330162
Cognitive disorder 23.08 9.62 41 115855 44082 50445146
Accidental overdose 22.97 9.62 8 115888 19525 50469703
Skin ulcer 22.93 9.62 149 115747 35169 50454059
Arthritis enteropathic 22.91 9.62 11 115885 220 50489008
Peripheral swelling 22.81 9.62 333 115563 205603 50283625
Myasthenia gravis 22.77 9.62 34 115862 3518 50485710
Conjunctivitis 22.74 9.62 85 115811 16060 50473168
HELLP syndrome 22.74 9.62 18 115878 901 50488327
Spinal cord infection 22.53 9.62 15 115881 572 50488656
Tenosynovitis 22.46 9.62 64 115832 10501 50478727
Gastrointestinal haemorrhage 22.45 9.62 89 115807 73232 50415996
Cytomegalovirus hepatitis 22.39 9.62 12 115884 305 50488923
Small intestinal stenosis 22.30 9.62 14 115882 482 50488746
Body temperature fluctuation 22.29 9.62 25 115871 1948 50487280
Hepatosplenomegaly 22.28 9.62 27 115869 2285 50486943
Therapeutic response shortened 22.19 9.62 51 115845 7338 50481890
Oesophageal squamous cell carcinoma 21.98 9.62 9 115887 121 50489107
Intestinal anastomosis 21.97 9.62 12 115884 317 50488911
Myocardial infarction 21.94 9.62 117 115779 88910 50400318
Gastrointestinal stoma output abnormal 21.91 9.62 7 115889 43 50489185
Emotional distress 21.88 9.62 20 115876 28643 50460585
Nocardiosis 21.77 9.62 23 115873 1675 50487553
Anaplastic large cell lymphoma T- and null-cell types 21.77 9.62 7 115889 44 50489184
Corynebacterium infection 21.76 9.62 13 115883 409 50488819
Congenital syphilitic osteochondritis 21.74 9.62 6 115890 20 50489208
T-cell lymphoma 21.48 9.62 15 115881 619 50488609
Proctalgia 21.47 9.62 40 115856 4963 50484265
Primary biliary cholangitis 21.44 9.62 19 115877 1113 50488115
Hydrops foetalis 21.44 9.62 12 115884 333 50488895
Pneumocystis jirovecii infection 21.40 9.62 20 115876 1255 50487973
Porokeratosis 21.40 9.62 9 115887 130 50489098
Vomiting 21.36 9.62 851 115045 459907 50029321
Delirium 21.35 9.62 34 115862 38158 50451070
Skin lesion 21.34 9.62 119 115777 26608 50462620
Femur fracture 21.28 9.62 33 115863 37431 50451797
Disturbance in attention 21.26 9.62 24 115872 31162 50458066
Hepatitis 21.23 9.62 134 115762 31319 50457909
Abnormal faeces 21.16 9.62 36 115860 4160 50485068
Rectal haemorrhage 21.10 9.62 156 115740 38402 50450826
Aplasia pure red cell 21.04 9.62 36 115860 4179 50485049
Antineutrophil cytoplasmic antibody increased 21.01 9.62 7 115889 50 50489178
Candida infection 21 9.62 108 115788 23415 50465813
Oedema peripheral 20.95 9.62 246 115650 157715 50331513
Lymphadenopathy 20.95 9.62 140 115756 33359 50455869
Therapy interrupted 20.86 9.62 10 115886 20142 50469086
Atypical haemolytic uraemic syndrome 20.82 9.62 14 115882 543 50488685
Anorectal disorder 20.79 9.62 21 115875 1451 50487777
Brain abscess 20.76 9.62 23 115873 1768 50487460
Cholesteatoma 20.68 9.62 9 115887 142 50489086
Congenital cytomegalovirus infection 20.65 9.62 5 115891 8 50489220
Small intestine carcinoma 20.48 9.62 12 115884 364 50488864
Fistula of small intestine 20.47 9.62 11 115885 281 50488947
Disorientation 20.40 9.62 31 115865 35453 50453775
Dysplasia 20.32 9.62 15 115881 676 50488552
Renal tubular atrophy 20.30 9.62 14 115882 566 50488662
Fistula discharge 20.28 9.62 17 115879 923 50488305
Sleep apnoea syndrome 20.27 9.62 15 115881 23853 50465375
Appendicitis 20.20 9.62 46 115850 6578 50482650
Anal cancer 20.19 9.62 13 115883 468 50488760
Cerebral toxoplasmosis 20.16 9.62 15 115881 684 50488544
Sebaceous carcinoma 20.15 9.62 6 115890 28 50489200
Lupus myocarditis 20.10 9.62 7 115889 58 50489170
International normalised ratio increased 20.06 9.62 43 115853 43109 50446119
Neuromyelitis optica spectrum disorder 20.05 9.62 16 115880 810 50488418
Cough 20.00 9.62 411 115485 240853 50248375
Infusion related reaction 19.94 9.62 519 115377 169038 50320190
Herpes simplex reactivation 19.87 9.62 12 115884 385 50488843
Actinic keratosis 19.84 9.62 25 115871 2202 50487026
Chronic hepatitis 19.82 9.62 16 115880 824 50488404
Dementia 19.79 9.62 6 115890 15991 50473237
Paraesthesia 19.75 9.62 178 115718 120065 50369163
Gastrointestinal scarring 19.72 9.62 10 115886 226 50489002
Ileostomy closure 19.71 9.62 8 115888 105 50489123
Gestational diabetes 19.70 9.62 49 115847 7416 50481812
Transaminases increased 19.69 9.62 120 115776 27704 50461524
Gastrointestinal fistula 19.62 9.62 12 115884 394 50488834
Pericarditis 19.62 9.62 103 115793 78586 50410642
Granuloma skin 19.55 9.62 42 115854 5776 50483452
Weight decreased 19.43 9.62 653 115243 220592 50268636
Thrombotic microangiopathy 19.42 9.62 54 115842 8737 50480491
Rectal stenosis 19.41 9.62 9 115887 166 50489062
Hyperadrenocorticism 19.37 9.62 11 115885 314 50488914
Blood parathyroid hormone decreased 19.09 9.62 47 115849 7067 50482161
Adverse drug reaction 19.08 9.62 202 115694 55020 50434208
Device issue 19.07 9.62 11 115885 19961 50469267
Trichostasis spinulosa 19.03 9.62 5 115891 13 50489215
Anal ulcer 18.97 9.62 13 115883 520 50488708
Malignant polyp 18.88 9.62 9 115887 177 50489051
External auditory canal atresia 18.86 9.62 7 115889 71 50489157
Poisoning 18.72 9.62 3 115893 12426 50476802
Pruritus 18.52 9.62 501 115395 283067 50206161
Lethargy 18.52 9.62 55 115841 49377 50439851
Sinusitis 18.46 9.62 277 115619 170281 50318947
Malignant melanoma 18.43 9.62 58 115838 10050 50479178
Gastrointestinal wall thickening 18.30 9.62 17 115879 1059 50488169
Ill-defined disorder 18.26 9.62 64 115832 54590 50434638
Transient hypogammaglobulinaemia of infancy 18.23 9.62 6 115890 41 50489187
Underdose 18.21 9.62 12 115884 20266 50468962
Peritonitis 18.17 9.62 77 115819 15409 50473819
Epistaxis 18.10 9.62 80 115816 63874 50425354
Muscle spasms 18.04 9.62 192 115704 125361 50363867
Epstein-Barr virus associated lymphoma 18.04 9.62 12 115884 457 50488771
Vision blurred 17.94 9.62 106 115790 78541 50410687
Pulmonary oedema 17.94 9.62 55 115841 48883 50440345
Hypocalcaemia 17.89 9.62 21 115875 26795 50462433
Rheumatoid lung 17.85 9.62 25 115871 2440 50486788
Anorectal stenosis 17.82 9.62 5 115891 18 50489210
Weber tuning fork test abnormal 17.81 9.62 7 115889 84 50489144
Throat cancer 17.81 9.62 12 115884 467 50488761
Withdrawal syndrome 17.80 9.62 9 115887 17581 50471647
Lung abscess 17.75 9.62 20 115876 1566 50487662
Abortion missed 17.73 9.62 20 115876 1568 50487660
Transient ischaemic attack 17.70 9.62 29 115867 32181 50457047
Eye ulcer 17.66 9.62 10 115886 284 50488944
Hip fracture 17.63 9.62 20 115876 25911 50463317
Creatinine renal clearance decreased 17.60 9.62 3 115893 11878 50477350
Pseudoxanthoma elasticum-like syndrome 17.56 9.62 4 115892 4 50489224
Mitochondrial neurogastrointestinal encephalopathy 17.56 9.62 4 115892 4 50489224
Meningitis listeria 17.56 9.62 12 115884 478 50488750
Drug level abnormal 17.52 9.62 7 115889 88 50489140
Anaplastic large-cell lymphoma 17.38 9.62 7 115889 90 50489138
Bowel movement irregularity 17.37 9.62 32 115864 3936 50485292
Bronchomalacia 17.37 9.62 9 115887 213 50489015
Neutropenia 17.17 9.62 237 115659 147728 50341500
Abnormal behaviour 17.16 9.62 12 115884 19646 50469582
Metastases to bone 17.06 9.62 10 115886 17985 50471243
Pulmonary embolism 16.94 9.62 150 115746 101554 50387674
Retinal injury 16.93 9.62 9 115887 225 50489003
Polyhydramnios 16.89 9.62 22 115874 2003 50487225
Aspergillosis oral 16.80 9.62 6 115890 54 50489174
Gait disturbance 16.80 9.62 242 115654 149763 50339465
Proctectomy 16.80 9.62 6 115890 54 50489174
Carcinoid tumour pulmonary 16.70 9.62 11 115885 412 50488816
Nightmare 16.63 9.62 8 115888 16078 50473150
Defaecation urgency 16.60 9.62 27 115869 3006 50486222
Microsporidia infection 16.57 9.62 9 115887 235 50488993
Oral lichen planus 16.55 9.62 12 115884 526 50488702
Stress at work 16.54 9.62 16 115880 1049 50488179
Enterostomy 16.44 9.62 8 115888 165 50489063
Pancreatitis acute 16.41 9.62 102 115794 23710 50465518
Gingival hypertrophy 16.41 9.62 18 115878 1368 50487860
Metastases to central nervous system 16.38 9.62 3 115893 11279 50477949
Symptom masked 16.33 9.62 13 115883 656 50488572
Palatal ulcer 16.15 9.62 6 115890 61 50489167
Inappropriate antidiuretic hormone secretion 16.13 9.62 5 115891 13138 50476090
Hyperthyroidism 16.12 9.62 4 115892 12171 50477057
Anal squamous cell carcinoma 16.07 9.62 10 115886 339 50488889
Blood glucose decreased 16.05 9.62 11 115885 18200 50471028
Synovitis 16.00 9.62 384 115512 123481 50365747
B-cell unclassifiable lymphoma high grade 15.95 9.62 4 115892 8 50489220
Pulmonary necrosis 15.94 9.62 7 115889 113 50489115
Faecal calprotectin abnormal 15.90 9.62 6 115890 64 50489164
Poor venous access 15.88 9.62 56 115840 10284 50478944
Obstructive airways disorder 15.85 9.62 8 115888 15644 50473584
Squamous cell carcinoma of the tongue 15.83 9.62 10 115886 348 50488880
Pain in extremity 15.82 9.62 490 115406 272375 50216853
American trypanosomiasis 15.81 9.62 6 115890 65 50489163
Injection site warmth 15.76 9.62 6 115890 13860 50475368
Exercise tolerance increased 15.75 9.62 5 115891 30 50489198
Congenital bowing of long bones 15.73 9.62 6 115890 66 50489162
Patent ductus arteriosus 15.72 9.62 30 115866 3790 50485438
Cleft lip and palate 15.71 9.62 10 115886 353 50488875
Muscle spasticity 15.66 9.62 10 115886 17174 50472054
Complex regional pain syndrome 15.62 9.62 21 115875 1972 50487256
Knee arthroplasty 15.62 9.62 37 115859 35809 50453419
Acute respiratory distress syndrome 15.57 9.62 92 115804 21007 50468221
Memory impairment 15.55 9.62 112 115784 79248 50409980
Therapy non-responder 15.52 9.62 182 115714 50840 50438388
Diabetic ketoacidosis 15.48 9.62 11 115885 17861 50471367
Pleural effusion 15.46 9.62 116 115780 81338 50407890
Torsade de pointes 15.45 9.62 4 115892 11831 50477397
Hirsutism 15.44 9.62 15 115881 988 50488240
Fear 15.40 9.62 7 115889 14542 50474686
Tonsillar hypertrophy 15.34 9.62 14 115882 852 50488376
Listeria sepsis 15.29 9.62 12 115884 593 50488635
Lung infiltration 15.25 9.62 66 115830 13327 50475901
Oral pain 15.25 9.62 21 115875 25012 50464216
Irritability 15.24 9.62 26 115870 28400 50460828
Opportunistic infection 15.21 9.62 19 115877 1659 50487569
Coronary artery disease 15.21 9.62 28 115868 29698 50459530
Infertility 15.15 9.62 12 115884 601 50488627
Acute febrile neutrophilic dermatosis 15.12 9.62 24 115872 2618 50486610
Injection site pruritus 15.11 9.62 45 115851 40366 50448862
Superinfection 15.11 9.62 21 115875 2035 50487193
Deep vein thrombosis 15.08 9.62 102 115794 73202 50416026
Retinal toxicity 15.07 9.62 16 115880 1172 50488056
Acne conglobata 15.06 9.62 4 115892 11 50489217
Anterograde amnesia 14.99 9.62 11 115885 491 50488737
Anovulatory cycle 14.86 9.62 7 115889 134 50489094
DNA antibody 14.85 9.62 5 115891 37 50489191
Mucormycosis 14.83 9.62 23 115873 2460 50486768
Dry skin 14.81 9.62 50 115846 43141 50446087
Tonsillitis 14.81 9.62 34 115862 4889 50484339
Mucosal inflammation 14.80 9.62 45 115851 40097 50449131
Head injury 14.78 9.62 20 115876 24000 50465228
Mucous stools 14.77 9.62 25 115871 2877 50486351
Polyomavirus-associated nephropathy 14.76 9.62 18 115878 1534 50487694
Lymphoma 14.75 9.62 52 115844 9549 50479679
Product administration error 14.74 9.62 14 115882 19685 50469543
Steatorrhoea 14.73 9.62 10 115886 394 50488834
Aggression 14.67 9.62 16 115880 21100 50468128
Bulimia nervosa 14.66 9.62 10 115886 397 50488831
Gastrointestinal motility disorder 14.52 9.62 32 115864 4477 50484751
Cutaneous leishmaniasis 14.50 9.62 6 115890 83 50489145
Failed induction of labour 14.44 9.62 9 115887 306 50488922
Pseudomonas infection 14.42 9.62 51 115845 9379 50479849
Tuberous sclerosis complex 14.37 9.62 6 115890 85 50489143
Cervix carcinoma 14.37 9.62 23 115873 2527 50486701
Cranial sutures widening 14.34 9.62 4 115892 14 50489214
Gastrointestinal oedema 14.30 9.62 15 115881 1083 50488145
Hepatitis viral 14.29 9.62 10 115886 414 50488814
Arthropathy 14.29 9.62 265 115631 157641 50331587
Legionella infection 14.21 9.62 10 115886 418 50488810
Pelvic abscess 14.20 9.62 17 115879 1421 50487807
Contraindicated product administered 14.19 9.62 444 115452 148514 50340714
Nervousness 14.19 9.62 26 115870 27625 50461603
Sepsis neonatal 14.16 9.62 10 115886 420 50488808
Pyometra 14.06 9.62 6 115890 90 50489138
Anal stenosis 14.05 9.62 9 115887 321 50488907
Intestinal anastomosis complication 14.04 9.62 8 115888 230 50488998
Melaena 14.02 9.62 25 115871 26839 50462389
Abnormal palmar/plantar creases 14.00 9.62 5 115891 45 50489183
Hypervolaemia 13.97 9.62 23 115873 25476 50463752
Ureteral neoplasm 13.93 9.62 4 115892 16 50489212
Asthma 13.91 9.62 134 115762 89203 50400025
Herpes virus infection 13.90 9.62 33 115863 4848 50484380
Foetal exposure during delivery 13.90 9.62 5 115891 46 50489182
Post procedural diarrhoea 13.89 9.62 7 115889 156 50489072
Atypical mycobacterial infection 13.84 9.62 13 115883 821 50488407
Intestinal operation 13.82 9.62 10 115886 437 50488791
Calciphylaxis 13.79 9.62 23 115873 2615 50486613
Acute myocardial infarction 13.75 9.62 29 115867 29244 50459984
Lymphocytopenia neonatal 13.73 9.62 4 115892 17 50489211
Cytomegalovirus mucocutaneous ulcer 13.73 9.62 4 115892 17 50489211
Upper gastrointestinal haemorrhage 13.72 9.62 10 115886 16025 50473203
Eye infection fungal 13.71 9.62 6 115890 96 50489132
Anastomotic stenosis 13.70 9.62 8 115888 241 50488987
Haematoma 13.69 9.62 31 115865 30479 50458749
Intestinal polyp 13.65 9.62 15 115881 1142 50488086
Microscopic polyangiitis 13.65 9.62 7 115889 162 50489066
Endocarditis noninfective 13.62 9.62 5 115891 49 50489179
Amniotic cavity infection 13.59 9.62 15 115881 1148 50488080
Cytomegalovirus chorioretinitis 13.56 9.62 17 115879 1490 50487738
Pollakiuria 13.55 9.62 21 115875 23830 50465398
Impetigo 13.55 9.62 15 115881 1152 50488076
Muscular dystrophy 13.55 9.62 4 115892 18 50489210
Skin necrosis 13.50 9.62 55 115841 10812 50478416
Microtia 13.50 9.62 9 115887 344 50488884
Conjunctivitis allergic 13.50 9.62 12 115884 706 50488522
Stoma site extravasation 13.49 9.62 8 115888 248 50488980
Muscle rigidity 13.47 9.62 3 115893 9826 50479402
Chorioretinitis 13.39 9.62 10 115886 459 50488769
Heart rate irregular 13.39 9.62 83 115813 19277 50469951
Fasting 13.37 9.62 4 115892 19 50489209
Dyspepsia 13.37 9.62 107 115789 73990 50415238
Dysphonia 13.35 9.62 45 115851 38847 50450381
Hyperglycaemia 13.28 9.62 41 115855 36364 50452864
Upper respiratory tract irritation 13.27 9.62 5 115891 53 50489175
Mediastinal effusion 13.27 9.62 5 115891 53 50489175
Cafe au lait spots 13.20 9.62 4 115892 20 50489208
Urinary incontinence 13.20 9.62 28 115868 28180 50461048
Neoplasm skin 13.18 9.62 14 115882 1026 50488202
Congenital toxoplasmosis 13.17 9.62 3 115893 3 50489225
Injection site mass 13.13 9.62 10 115886 15670 50473558
Glomerulonephritis 13.10 9.62 17 115879 1542 50487686
Blood potassium increased 13.05 9.62 11 115885 16387 50472841
Photophobia 13.05 9.62 68 115828 14819 50474409
Precursor T-lymphoblastic lymphoma/leukaemia 13.04 9.62 4 115892 21 50489207
Fibroadenoma of breast 13.03 9.62 9 115887 365 50488863
Migraine 12.99 9.62 110 115786 75170 50414058
Anaemia macrocytic 12.96 9.62 22 115874 2537 50486691
Hepatitis cholestatic 12.95 9.62 37 115859 6080 50483148
Hepatitis E 12.91 9.62 15 115881 1214 50488014
Device breakage 12.91 9.62 3 115893 9544 50479684
Ejection fraction decreased 12.90 9.62 14 115882 18506 50470722
Therapy cessation 12.87 9.62 25 115871 25986 50463242
Myelitis 12.86 9.62 15 115881 1219 50488009
Kidney fibrosis 12.85 9.62 17 115879 1572 50487656
Lung disorder 12.83 9.62 158 115738 44641 50444587
Anaemia 12.83 9.62 461 115435 251995 50237233
Drug level above therapeutic 12.83 9.62 28 115868 3892 50485336
Lacrimation increased 12.80 9.62 12 115884 16980 50472248
Complications of transplanted kidney 12.80 9.62 20 115876 2153 50487075
Myopathy 12.77 9.62 48 115848 9091 50480137
Product storage error 12.76 9.62 6 115890 12218 50477010
Myasthenia gravis crisis 12.73 9.62 9 115887 379 50488849
Primary effusion lymphoma 12.71 9.62 3 115893 4 50489224
Acinetobacter infection 12.68 9.62 16 115880 1411 50487817
Staphylococcal skin infection 12.66 9.62 12 115884 767 50488461
Hot flush 12.65 9.62 55 115841 44114 50445114
Hypoaesthesia 12.65 9.62 210 115686 127047 50362181
Coloboma 12.65 9.62 5 115891 61 50489167
Transplant dysfunction 12.63 9.62 31 115865 4653 50484575
Epidermodysplasia verruciformis 12.57 9.62 5 115891 62 50489166
Anuria 12.56 9.62 5 115891 11239 50477989
Threatened labour 12.55 9.62 12 115884 775 50488453
Neutrophilic dermatosis 12.54 9.62 6 115890 119 50489109
JC virus infection 12.54 9.62 18 115878 1797 50487431
Lymphocele 12.49 9.62 12 115884 780 50488448
Staphylococcal sepsis 12.48 9.62 40 115856 6996 50482232
Enterococcal sepsis 12.47 9.62 15 115881 1260 50487968
Necrosis 12.40 9.62 31 115865 4705 50484523
Food intolerance 12.37 9.62 21 115875 2423 50486805
Anastomotic complication 12.36 9.62 6 115890 123 50489105
Disease risk factor 12.36 9.62 5 115891 65 50489163
Dysarthria 12.36 9.62 44 115852 37359 50451869
Placental necrosis 12.33 9.62 4 115892 26 50489202
Skin laceration 12.31 9.62 15 115881 18827 50470401
Speech disorder 12.30 9.62 41 115855 35507 50453721
Double stranded DNA antibody positive 12.28 9.62 8 115888 294 50488934
Intra-abdominal fluid collection 12.26 9.62 19 115877 2031 50487197
Necrotising retinitis 12.25 9.62 8 115888 295 50488933
Mucosal necrosis 12.20 9.62 4 115892 27 50489201
Muir-Torre syndrome 12.20 9.62 4 115892 27 50489201
Lacrimal haemorrhage 12.20 9.62 4 115892 27 50489201
Seronegative arthritis 12.18 9.62 19 115877 2042 50487186
Colostomy 12.15 9.62 11 115885 663 50488565
Ventricular tachycardia 12.12 9.62 11 115885 15810 50473418
Encephalitis cytomegalovirus 12.11 9.62 10 115886 532 50488696
Cavernous sinus thrombosis 12.06 9.62 6 115890 130 50489098
Ocular toxicity 12.06 9.62 10 115886 535 50488693
Skin cancer 12.04 9.62 48 115848 9346 50479882
Sciatica 11.98 9.62 87 115809 21295 50467933
Gastrointestinal stoma complication 11.97 9.62 16 115880 1494 50487734
Central nervous system necrosis 11.94 9.62 6 115890 133 50489095
Electrolyte imbalance 11.94 9.62 13 115883 17156 50472072
Depressed mood 11.93 9.62 39 115857 33984 50455244
Bacillary angiomatosis 11.90 9.62 5 115891 72 50489156
Gastritis haemorrhagic 11.90 9.62 15 115881 1322 50487906
Abdominal pain lower 11.89 9.62 88 115808 21668 50467560
Mouth ulceration 11.88 9.62 107 115789 27917 50461311
Tenderness 11.85 9.62 78 115818 18487 50470741
Varicella zoster pneumonia 11.83 9.62 4 115892 30 50489198
Histiocytic necrotising lymphadenitis 11.83 9.62 4 115892 30 50489198
Cholestasis 11.82 9.62 99 115797 25302 50463926
Throat irritation 11.80 9.62 33 115863 30206 50459022
Complications of transplanted lung 11.78 9.62 7 115889 218 50489010
Meningitis aseptic 11.75 9.62 28 115868 4124 50485104
Enteritis 11.72 9.62 39 115857 6956 50482272
Ear pain 11.69 9.62 30 115866 28253 50460975
DNA antibody positive 11.68 9.62 8 115888 320 50488908
Ileal ulcer 11.66 9.62 9 115887 434 50488794
Type 2 diabetes mellitus 11.65 9.62 40 115856 34335 50454893
Cheilitis granulomatosa 11.65 9.62 3 115893 7 50489221
Hypergammaglobulinaemia 11.62 9.62 9 115887 436 50488792
Hallucination, auditory 11.61 9.62 5 115891 10723 50478505
Gastroenteritis norovirus 11.60 9.62 17 115879 1730 50487498
Sepsis 11.57 9.62 392 115504 132533 50356695
Sinus bradycardia 11.57 9.62 8 115888 13175 50476053
Pyoderma 11.55 9.62 7 115889 226 50489002
Limb discomfort 11.55 9.62 24 115872 24333 50464895
Maternal exposure during breast feeding 11.52 9.62 24 115872 3230 50485998
Infective tenosynovitis 11.50 9.62 7 115889 228 50489000
Occult blood 11.48 9.62 14 115882 1193 50488035
Concussion 11.45 9.62 41 115855 7587 50481641
Perirectal abscess 11.44 9.62 12 115884 867 50488361
Haemophilus infection 11.43 9.62 13 115883 1028 50488200
Salmonella bacteraemia 11.39 9.62 6 115890 147 50489081
Cytopenia 11.37 9.62 45 115851 8730 50480498
Delusion 11.32 9.62 5 115891 10564 50478664
Thrombocytopenia 11.32 9.62 215 115681 127458 50361770
Cholecystitis chronic 11.30 9.62 4 115892 9665 50479563
Large intestinal ulcer 11.30 9.62 23 115873 3046 50486182
Respiratory gas exchange disorder 11.29 9.62 8 115888 338 50488890
Hypoglycaemic seizure 11.27 9.62 9 115887 456 50488772
Pulmonary congestion 11.22 9.62 11 115885 15236 50473992
Eye swelling 11.20 9.62 18 115878 20126 50469102
Cervical incompetence 11.19 9.62 10 115886 592 50488636
Anger 11.17 9.62 6 115890 11327 50477901
Myoclonus 11.16 9.62 10 115886 14460 50474768
Blood immunoglobulin M increased 11.15 9.62 7 115889 241 50488987
Metastases to liver 11.14 9.62 18 115878 20086 50469142
Steroid dependence 11.11 9.62 8 115888 347 50488881
Moraxella infection 11.09 9.62 8 115888 348 50488880
Renal cell carcinoma 11.05 9.62 23 115873 3094 50486134
Macular degeneration 11.03 9.62 10 115886 14378 50474850
Hypophagia 11.01 9.62 30 115866 27698 50461530
Mental disorder 11.00 9.62 21 115875 21970 50467258
Haematocrit decreased 10.99 9.62 42 115854 34934 50454294
Granuloma 10.89 9.62 30 115866 4828 50484400
Vascular shunt 10.87 9.62 3 115893 10 50489218
Obliterative bronchiolitis 10.84 9.62 17 115879 1836 50487392
Proctocolectomy 10.83 9.62 4 115892 40 50489188
Proctitis ulcerative 10.80 9.62 7 115889 255 50488973
Intestinal dilatation 10.80 9.62 15 115881 1453 50487775
Stillbirth 10.71 9.62 34 115862 5918 50483310
Small intestinal perforation 10.67 9.62 14 115882 1284 50487944
Tuberculosis of eye 10.65 9.62 3 115893 11 50489217
Hypocomplementaemia 10.64 9.62 6 115890 169 50489059
Neuropsychiatric lupus 10.64 9.62 6 115890 169 50489059
Appendicectomy 10.62 9.62 20 115876 2502 50486726
Laryngeal stenosis 10.58 9.62 11 115885 786 50488442
Neuroendocrine carcinoma metastatic 10.57 9.62 6 115890 171 50489057
Pneumatosis intestinalis 10.55 9.62 18 115878 2085 50487143
Burning sensation 10.50 9.62 61 115835 45385 50443843
Feeling jittery 10.50 9.62 52 115844 11108 50478120
Dermatitis psoriasiform 10.46 9.62 16 115880 1690 50487538
Renal phospholipidosis 10.46 9.62 5 115891 99 50489129
Haemorrhage in pregnancy 10.44 9.62 16 115880 1693 50487535
Pulmonary venous thrombosis 10.44 9.62 3 115893 12 50489216
Leiomyosarcoma metastatic 10.44 9.62 3 115893 12 50489216
Febrile convulsion 10.43 9.62 8 115888 382 50488846
Small intestinal resection 10.43 9.62 8 115888 382 50488846
Muscle twitching 10.38 9.62 12 115884 15419 50473809
Anaphylactic shock 10.30 9.62 19 115877 20136 50469092
Pharyngeal oedema 10.27 9.62 9 115887 13156 50476072
Rectal cancer 10.27 9.62 16 115880 1718 50487510
Intestinal fistula infection 10.25 9.62 3 115893 13 50489215
Hodgkin's disease stage II 10.25 9.62 3 115893 13 50489215
Adjustment disorder with depressed mood 10.25 9.62 21 115875 2793 50486435
Lentigo maligna 10.24 9.62 6 115890 182 50489046
Hyperparathyroidism secondary 10.24 9.62 14 115882 1336 50487892
Central nervous system vasculitis 10.24 9.62 11 115885 817 50488411
Cytomegalovirus test positive 10.23 9.62 20 115876 2572 50486656
Vertigo 10.22 9.62 73 115823 51759 50437469
Rheumatic disorder 10.22 9.62 15 115881 1528 50487700
Metastatic malignant melanoma 10.18 9.62 13 115883 1161 50488067
Amnesia 10.15 9.62 56 115840 42204 50447024
Infected fistula 10.15 9.62 5 115891 106 50489122
Evans syndrome 10.15 9.62 6 115890 185 50489043
Panic attack 10.09 9.62 18 115878 19324 50469904
Febrile infection 10.09 9.62 13 115883 1171 50488057
Incorrect route of product administration 10.08 9.62 17 115879 18649 50470579
Mycetoma mycotic 10.07 9.62 3 115893 14 50489214
Ubiquinone decreased 10.07 9.62 3 115893 14 50489214
Affect lability 10.05 9.62 4 115892 8994 50480234
Hidradenitis 10.03 9.62 17 115879 1958 50487270
Photosensitivity reaction 9.98 9.62 57 115839 12854 50476374
Idiopathic pulmonary fibrosis 9.98 9.62 13 115883 1184 50488044
Bronchostenosis 9.98 9.62 8 115888 408 50488820
Polymyositis 9.95 9.62 15 115881 1565 50487663
Angina pectoris 9.91 9.62 29 115867 26159 50463069
Ischaemic nephropathy 9.90 9.62 3 115893 15 50489213
Spinal cord disorder 9.89 9.62 13 115883 1194 50488034
Blood sodium decreased 9.89 9.62 21 115875 21126 50468102
Renal colic 9.87 9.62 13 115883 1196 50488032
Rash pustular 9.87 9.62 35 115861 6446 50482782
Nail disorder 9.77 9.62 5 115891 9703 50479525
Pouchitis 9.76 9.62 8 115888 421 50488807
Campylobacter infection 9.76 9.62 10 115886 703 50488525
Portal venous gas 9.75 9.62 4 115892 54 50489174
Retinitis viral 9.74 9.62 3 115893 16 50489212
Infective aortitis 9.74 9.62 3 115893 16 50489212
Immune-mediated myositis 9.74 9.62 12 115884 1033 50488195
Iron deficiency anaemia 9.72 9.62 69 115827 16765 50472463
Infective pulmonary exacerbation of cystic fibrosis 9.72 9.62 3 115893 7906 50481322
Scedosporium infection 9.71 9.62 8 115888 424 50488804
Breast adenoma 9.69 9.62 4 115892 55 50489173
Mental impairment 9.68 9.62 8 115888 12036 50477192
Drug specific antibody 9.66 9.62 16 115880 1809 50487419
Butterfly rash 9.65 9.62 13 115883 1223 50488005

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Colitis ulcerative 388.86 10.71 278 64508 12491 29497250
Drug ineffective 355.68 10.71 1651 63135 361519 29148222
Off label use 352.65 10.71 1444 63342 299356 29210385
Drug eruption 272.67 10.71 253 64533 16488 29493253
Hepatosplenic T-cell lymphoma 260.08 10.71 76 64710 346 29509395
Death 257.02 10.71 224 64562 341860 29167881
Post transplant lymphoproliferative disorder 218.18 10.71 141 64645 5352 29504389
Intestinal stenosis 213.24 10.71 97 64689 1791 29507950
Fistula 201.86 10.71 131 64655 5008 29504733
Nodular regenerative hyperplasia 196.88 10.71 69 64717 614 29509127
Cytomegalovirus infection 194.51 10.71 247 64539 22968 29486773
Epstein-Barr virus infection 189.62 10.71 139 64647 6490 29503251
Frequent bowel movements 170.82 10.71 150 64636 9089 29500652
Anal abscess 170.64 10.71 119 64667 5132 29504609
Hypersensitivity 166.68 10.71 362 64424 52541 29457200
Lymphoproliferative disorder 166.57 10.71 90 64696 2437 29507304
Intentional product use issue 166.13 10.71 318 64468 42180 29467561
Product use issue 162.05 10.71 352 64434 51092 29458649
Drug abuse 160.02 10.71 3 64783 79880 29429861
Diffuse large B-cell lymphoma 158.18 10.71 122 64664 6154 29503587
Completed suicide 149.57 10.71 13 64773 90233 29419508
Hepatic function abnormal 148.83 10.71 290 64496 38969 29470772
Ileal stenosis 135.20 10.71 62 64724 1167 29508574
Therapeutic product effect decreased 133.52 10.71 235 64551 29216 29480525
Intestinal obstruction 127.73 10.71 183 64603 19094 29490647
Anal fistula 124.60 10.71 90 64696 4105 29505636
Disseminated tuberculosis 124.10 10.71 68 64718 1894 29507847
Fall 119.78 10.71 127 64659 177051 29332690
Febrile neutropenia 119.76 10.71 48 64738 112192 29397549
Cytomegalovirus colitis 117.25 10.71 71 64715 2398 29507343
Crohn's disease 116.45 10.71 76 64710 2933 29506808
Squamous cell carcinoma 113.86 10.71 126 64660 10125 29499616
Hypotension 112.69 10.71 157 64629 194197 29315544
Disease recurrence 111.24 10.71 155 64631 15759 29493982
Condition aggravated 110.99 10.71 621 64165 145674 29364067
Haemophagocytic lymphohistiocytosis 109.64 10.71 125 64661 10379 29499362
Transplant rejection 108.88 10.71 117 64669 9095 29500646
Product use in unapproved indication 106.39 10.71 424 64362 86451 29423290
Treatment failure 104.23 10.71 242 64544 36697 29473044
Infusion related reaction 103.12 10.71 268 64518 43618 29466123
Toxicity to various agents 102.94 10.71 138 64648 173523 29336218
Urticaria 99.24 10.71 304 64482 54356 29455385
Stomatitis 99.13 10.71 238 64548 36875 29472866
Premature baby 98.65 10.71 153 64633 17127 29492614
Malignant neoplasm progression 98.07 10.71 21 64765 73838 29435903
JC virus infection 96.44 10.71 57 64729 1840 29507901
Large intestinal stenosis 96.11 10.71 51 64735 1330 29508411
Pulmonary tuberculosis 96.10 10.71 78 64708 4237 29505504
Blood pressure fluctuation 94.40 10.71 162 64624 19732 29490009
Inappropriate schedule of product administration 93.84 10.71 261 64525 44211 29465530
Acute febrile neutrophilic dermatosis 93.13 10.71 46 64740 1028 29508713
Progressive multifocal leukoencephalopathy 93.11 10.71 105 64681 8614 29501127
Leukopenia 92.84 10.71 299 64487 54904 29454837
Drug level below therapeutic 92.59 10.71 76 64710 4195 29505546
Pneumocystis jirovecii pneumonia 92.23 10.71 146 64640 16633 29493108
Pancytopenia 91.66 10.71 393 64393 82775 29426966
Cushingoid 90.50 10.71 60 64726 2378 29507363
Faecal calprotectin increased 90.26 10.71 51 64735 1510 29508231
Dizziness 88.77 10.71 176 64610 189508 29320233
Intestinal fistula 86.55 10.71 41 64745 833 29508908
Epstein-Barr virus associated lymphoproliferative disorder 85.17 10.71 51 64735 1687 29508054
Myocardial infarction 85.12 10.71 70 64716 110226 29399515
Somnolence 81.09 10.71 53 64733 93902 29415839
Drug level decreased 80.34 10.71 83 64703 6164 29503577
Drug specific antibody present 78.47 10.71 56 64730 2505 29507236
Basal cell carcinoma 78.00 10.71 136 64650 16774 29492967
Kidney transplant rejection 77.61 10.71 86 64700 6919 29502822
Erythema nodosum 77.51 10.71 39 64747 908 29508833
Tuberculosis 77.42 10.71 87 64699 7109 29502632
Intestinal resection 77.14 10.71 45 64741 1417 29508324
Colitis 74.59 10.71 192 64594 31056 29478685
Epistaxis 74.55 10.71 266 64520 51438 29458303
Acute kidney injury 74.38 10.71 314 64472 264953 29244788
Human herpesvirus 8 infection 72.62 10.71 36 64750 811 29508930
Cardiac failure congestive 71.99 10.71 39 64747 76542 29433199
Small intestinal stenosis 71.07 10.71 29 64757 405 29509336
Squamous cell carcinoma of skin 70.21 10.71 95 64691 9391 29500350
Diarrhoea haemorrhagic 70.11 10.71 75 64711 5799 29503942
Abdominal pain 67.88 10.71 518 64268 134839 29374902
Coombs positive haemolytic anaemia 67.57 10.71 33 64753 719 29509022
Dyspnoea 67.28 10.71 430 64356 326302 29183439
Pemphigus 67.10 10.71 38 64748 1130 29508611
Gastrointestinal inflammation 66.20 10.71 54 64732 2954 29506787
Epidermodysplasia verruciformis 65.63 10.71 20 64766 108 29509633
Intentional overdose 65.32 10.71 5 64781 38523 29471218
Abscess 65.13 10.71 93 64693 9669 29500072
Confusional state 64.76 10.71 113 64673 127764 29381977
Bradycardia 63.79 10.71 32 64754 65597 29444144
Clear cell renal cell carcinoma 63.70 10.71 35 64751 980 29508761
Nocardiosis 62.41 10.71 54 64732 3206 29506535
Cytomegalovirus viraemia 62.24 10.71 73 64713 6247 29503494
T-cell lymphoma 61.93 10.71 33 64753 868 29508873
Muscle spasms 61.53 10.71 294 64492 64788 29444953
Atrial fibrillation 61.46 10.71 85 64701 105561 29404180
Immunosuppression 60.47 10.71 66 64720 5220 29504521
Therapeutic response shortened 60.43 10.71 63 64723 4728 29505013
Meningitis listeria 60.33 10.71 25 64761 364 29509377
Herpes zoster 60.07 10.71 173 64613 29879 29479862
Night sweats 59.85 10.71 113 64673 14819 29494922
Lung transplant rejection 59.79 10.71 30 64756 694 29509047
Product dose omission issue 59.70 10.71 74 64712 96309 29413432
Non-cirrhotic portal hypertension 59.29 10.71 22 64764 234 29509507
B-cell lymphoma 58.86 10.71 56 64730 3762 29505979
Lymphopenia 58.75 10.71 106 64680 13427 29496314
Lymphadenitis 58.33 10.71 39 64747 1568 29508173
Colectomy 58.25 10.71 38 64748 1465 29508276
Renal cell carcinoma 57.89 10.71 61 64725 4635 29505106
Hand deformity 57.18 10.71 43 64743 2087 29507654
Abdominal adhesions 57.16 10.71 35 64751 1206 29508535
Drug intolerance 55.87 10.71 232 64554 48147 29461594
Histoplasmosis disseminated 54.58 10.71 33 64753 1111 29508630
Hyponatraemia 54.57 10.71 41 64745 67592 29442149
Overdose 54.07 10.71 57 64729 79762 29429979
Epstein-Barr virus test positive 54.01 10.71 25 64761 481 29509260
Epstein-Barr virus associated lymphoma 53.76 10.71 26 64760 554 29509187
Cardiac arrest 53.75 10.71 65 64721 85526 29424215
Dehydration 53.14 10.71 107 64679 114641 29395100
Kaposi's sarcoma 52.11 10.71 29 64757 833 29508908
Heart transplant rejection 51.84 10.71 32 64754 1119 29508622
Cytomegalovirus enteritis 51.13 10.71 23 64763 413 29509328
Intestinal perforation 50.98 10.71 75 64711 8011 29501730
Haematochezia 50.52 10.71 187 64599 36796 29472945
Transplant dysfunction 50.48 10.71 41 64745 2229 29507512
Cardio-respiratory arrest 50.18 10.71 24 64762 50577 29459164
Neuropathy peripheral 48.92 10.71 50 64736 70977 29438764
Small intestinal obstruction 48.86 10.71 96 64690 12965 29496776
Defaecation urgency 48.49 10.71 36 64750 1713 29508028
Decreased appetite 48.49 10.71 160 64626 145182 29364559
Portal hypertension 47.89 10.71 48 64738 3438 29506303
Pneumonia aspiration 47.62 10.71 11 64775 36726 29473015
Chronic allograft nephropathy 47.57 10.71 30 64756 1090 29508651
Syncope 46.78 10.71 66 64720 81305 29428436
Lymphoma 46.57 10.71 80 64706 9748 29499993
Polyhydramnios 45.84 10.71 18 64768 226 29509515
Rebound effect 45.83 10.71 37 64749 1994 29507747
Anal fissure 44.84 10.71 42 64744 2766 29506975
Blood glucose increased 44.77 10.71 38 64748 58946 29450795
Loss of consciousness 43.63 10.71 59 64727 73997 29435744
Pain in extremity 43.26 10.71 400 64386 110033 29399708
Weight decreased 42.83 10.71 512 64274 150393 29359348
Peliosis hepatis 42.71 10.71 12 64774 46 29509695
Acute myocardial infarction 42.20 10.71 27 64759 48411 29461330
Aggression 41.62 10.71 13 64773 35528 29474213
Lymphocytopenia neonatal 41.55 10.71 9 64777 6 29509735
Aspergillus infection 41.07 10.71 79 64707 10502 29499239
Extrapulmonary tuberculosis 40.96 10.71 13 64773 82 29509659
Clostridium difficile infection 40.40 10.71 101 64685 16040 29493701
Delirium 40.12 10.71 18 64768 39379 29470362
Histoplasmosis 40.06 10.71 29 64757 1327 29508414
Rash 39.87 10.71 248 64538 189571 29320170
Rheumatoid factor negative 39.75 10.71 24 64762 806 29508935
Chronic obstructive pulmonary disease 39.74 10.71 20 64766 40935 29468806
Hypoglycaemia 39.39 10.71 29 64757 48317 29461424
Cholangitis sclerosing 38.98 10.71 26 64760 1041 29508700
Insomnia 38.37 10.71 86 64700 88675 29421066
Neuroendocrine carcinoma of the skin 37.87 10.71 21 64765 599 29509142
Plasma cell myeloma 37.73 10.71 17 64769 37098 29472643
Arthralgia 37.56 10.71 469 64317 139148 29370593
Therapeutic product effect incomplete 37.44 10.71 178 64608 39127 29470614
Bronchopulmonary aspergillosis 37.15 10.71 83 64703 12261 29497480
International normalised ratio increased 36.96 10.71 26 64760 44346 29465395
Candida infection 36.78 10.71 94 64692 15131 29494610
Cutaneous T-cell lymphoma 36.71 10.71 27 64759 1266 29508475
Rectal abscess 36.68 10.71 24 64762 930 29508811
Abnormal behaviour 36.52 10.71 4 64782 23123 29486618
Abscess intestinal 36.40 10.71 28 64758 1406 29508335
Infection reactivation 36.17 10.71 25 64761 1062 29508679
Rectal fissure 36.15 10.71 16 64770 276 29509465
Mycobacterial infection 36.04 10.71 31 64755 1825 29507916
Varicella zoster virus infection 35.82 10.71 28 64758 1440 29508301
Coma 35.74 10.71 21 64765 39429 29470312
Pancreatitis 35.60 10.71 160 64626 34354 29475387
Cerebrovascular accident 35.34 10.71 72 64714 76839 29432902
Mycoplasma infection 35.33 10.71 16 64770 292 29509449
Respiratory arrest 34.98 10.71 7 64779 25826 29483915
Lymphocyte count abnormal 34.94 10.71 20 64766 607 29509134
Electrocardiogram QT prolonged 34.53 10.71 18 64768 36119 29473622
Pyrexia 34.34 10.71 848 63938 286774 29222967
Wrong technique in product usage process 34.20 10.71 13 64773 31415 29478326
Inflammatory bowel disease 33.93 10.71 33 64753 2278 29507463
Oedema peripheral 33.82 10.71 115 64671 103442 29406299
Asthenia 33.43 10.71 306 64480 214944 29294797
Cardiac failure 33.32 10.71 78 64708 79209 29430532
Enterocutaneous fistula 33.25 10.71 21 64765 765 29508976
Visceral leishmaniasis 32.95 10.71 18 64768 498 29509243
Low birth weight baby 32.91 10.71 55 64731 6553 29503188
Actinic keratosis 32.82 10.71 41 64745 3745 29505996
Hypokalaemia 32.71 10.71 37 64749 50166 29459575
Lupus-like syndrome 32.65 10.71 32 64754 2230 29507511
Gastrointestinal disorder 32.61 10.71 137 64649 28569 29481172
Hallucination 32.49 10.71 30 64756 44682 29465059
Intestinal fibrosis 32.41 10.71 11 64775 88 29509653
Drug level above therapeutic 32.20 10.71 38 64748 3272 29506469
Red blood cell sedimentation rate abnormal 32.17 10.71 32 64754 2271 29507470
Gastrointestinal haemorrhage 32.03 10.71 80 64706 79453 29430288
Bone marrow failure 31.96 10.71 132 64654 27317 29482424
Vasculitis 31.77 10.71 60 64726 7868 29501873
Herpes simplex 31.76 10.71 46 64740 4844 29504897
Foetal growth restriction 31.41 10.71 40 64746 3726 29506015
Splenomegaly 31.06 10.71 81 64705 13198 29496543
Obliterative bronchiolitis 31.00 10.71 23 64763 1093 29508648
Abdominal abscess 30.92 10.71 40 64746 3784 29505957
Orthostatic hypotension 30.92 10.71 6 64780 22623 29487118
Neutrophil count decreased 30.75 10.71 30 64756 43537 29466204
Therapeutic response decreased 30.50 10.71 121 64665 24590 29485151
Urinary retention 30.31 10.71 16 64770 31882 29477859
Cystitis escherichia 29.98 10.71 12 64774 159 29509582
Anxiety 29.81 10.71 92 64694 85273 29424468
Fistula discharge 29.75 10.71 16 64770 429 29509312
Rectal haemorrhage 29.72 10.71 152 64634 34397 29475344
Gastrointestinal fistula 29.70 10.71 15 64771 352 29509389
Fatigue 29.39 10.71 503 64283 316318 29193423
Agitation 29.09 10.71 42 64744 51262 29458479
Balance disorder 29.07 10.71 22 64764 36148 29473593
Depressed level of consciousness 29.02 10.71 23 64763 36919 29472822
Nephropathy toxic 28.72 10.71 69 64717 10687 29499054
Heart rate irregular 28.65 10.71 78 64708 13039 29496702
Drug resistance 28.64 10.71 108 64678 21432 29488309
Cow pox 28.61 10.71 8 64778 30 29509711
Gastrointestinal lymphoma 28.61 10.71 8 64778 30 29509711
Myopathy 28.59 10.71 68 64718 10465 29499276
Lung neoplasm 28.44 10.71 41 64745 4299 29505442
Complications of transplanted kidney 28.35 10.71 39 64747 3915 29505826
Granulomatosis with polyangiitis 28.19 10.71 20 64766 886 29508855
Unresponsive to stimuli 28.00 10.71 10 64776 25116 29484625
Enteritis 27.96 10.71 52 64734 6739 29503002
Angina pectoris 27.93 10.71 13 64773 27837 29481904
Gastrointestinal wall thickening 27.90 10.71 22 64764 1146 29508595
Accidental overdose 27.89 10.71 3 64783 17590 29492151
Foetal exposure during pregnancy 27.75 10.71 147 64639 33720 29476021
Hospitalisation 27.73 10.71 36 64750 45952 29463789
Herpes zoster meningoencephalitis 27.72 10.71 13 64773 258 29509483
Limb deformity 27.71 10.71 16 64770 494 29509247
Mycobacterium chelonae infection 27.63 10.71 17 64769 591 29509150
White blood cell count decreased 27.60 10.71 92 64694 83270 29426471
Contusion 27.54 10.71 17 64769 31078 29478663
Pouchitis 27.50 10.71 17 64769 596 29509145
Disease progression 27.40 10.71 90 64696 81826 29427915
Scleroderma 27.32 10.71 23 64763 1315 29508426
Chronic gastrointestinal bleeding 27.09 10.71 13 64773 272 29509469
Dysgeusia 27.08 10.71 8 64778 22666 29487075
Listeria sepsis 27.06 10.71 11 64775 152 29509589
Cytomegalovirus infection reactivation 26.91 10.71 35 64751 3329 29506412
Intestinal anastomosis 26.91 10.71 12 64774 211 29509530
Liver transplant rejection 26.78 10.71 27 64759 1947 29507794
Seizure 26.75 10.71 109 64677 93014 29416727
Hepatitis 26.64 10.71 103 64683 20680 29489061
Papilloma viral infection 26.58 10.71 15 64771 443 29509298
Plasmablastic lymphoma 26.50 10.71 12 64774 219 29509522
Legionella infection 26.49 10.71 15 64771 446 29509295
Acquired gene mutation 26.46 10.71 22 64764 1236 29508505
Gait disturbance 26.36 10.71 78 64708 73271 29436470
Disorientation 26.33 10.71 16 64770 29499 29480242
Diffuse large B-cell lymphoma stage IV 26.16 10.71 12 64774 226 29509515
Eosinophilic bronchitis 26.13 10.71 11 64775 167 29509574
Tachycardia 26.02 10.71 77 64709 72333 29437408
Malignant melanoma 26.02 10.71 52 64734 7109 29502632
Congenital cytomegalovirus infection 25.74 10.71 7 64779 23 29509718
Myasthenia gravis crisis 25.61 10.71 15 64771 476 29509265
Myasthenic syndrome 25.45 10.71 14 64772 393 29509348
Ileostomy 25.44 10.71 15 64771 482 29509259
Complications of transplanted lung 25.44 10.71 11 64775 179 29509562
Graft versus host disease in lung 25.32 10.71 15 64771 486 29509255
Squamous cell carcinoma of the tongue 25.14 10.71 12 64774 248 29509493
Constipation 25.05 10.71 147 64639 114013 29395728
Strongyloidiasis 24.95 10.71 28 64758 2284 29507457
Molluscum contagiosum 24.76 10.71 12 64774 257 29509484
Transient ischaemic attack 24.70 10.71 10 64776 23260 29486481
Irritability 24.37 10.71 9 64777 22143 29487598
Periumbilical abscess 24.37 10.71 8 64778 57 29509684
Hepatosplenomegaly 24.19 10.71 35 64751 3682 29506059
Dyskinesia 24.10 10.71 7 64779 20054 29489687
Intestinal mass 24.08 10.71 14 64772 438 29509303
Epstein Barr virus positive mucocutaneous ulcer 23.82 10.71 12 64774 280 29509461
Body temperature fluctuation 23.76 10.71 22 64764 1428 29508313
Peritoneal abscess 23.68 10.71 8 64778 63 29509678
Meningitis cryptococcal 23.64 10.71 26 64760 2074 29507667
Steroid dependence 23.59 10.71 12 64774 286 29509455
Varicella 23.59 10.71 22 64764 1441 29508300
Hypocalcaemia 23.41 10.71 8 64778 20657 29489084
Phaeohyphomycosis 23.38 10.71 17 64769 783 29508958
Therapeutic reaction time decreased 23.37 10.71 16 64770 669 29509072
Osteonecrosis of jaw 23.37 10.71 4 64782 16506 29493235
Tonsil cancer 23.24 10.71 18 64768 913 29508828
Non-Hodgkin's lymphoma 23.16 10.71 22 64764 1475 29508266
Chronic myeloid leukaemia 22.99 10.71 25 64761 1969 29507772
Hydrops foetalis 22.98 10.71 11 64775 229 29509512
Lung abscess 22.75 10.71 27 64759 2339 29507402
Lupus nephritis 22.68 10.71 11 64775 236 29509505
Eosinophilic granulomatosis with polyangiitis 22.65 10.71 21 64765 1365 29508376
Systemic lupus erythematosus 22.58 10.71 28 64758 2538 29507203
Bone erosion 22.52 10.71 29 64757 2731 29507010
C-reactive protein increased 22.45 10.71 170 64616 44093 29465648
Intestinal anastomosis complication 22.30 10.71 9 64777 122 29509619
Product prescribing error 22.10 10.71 6 64780 17970 29491771
Listeria encephalitis 22.08 10.71 7 64779 44 29509697
Mucosal inflammation 22.01 10.71 22 64764 31573 29478168
Pulmonary vasculitis 21.91 10.71 9 64777 128 29509613
Cytomegalovirus chorioretinitis 21.82 10.71 31 64755 3207 29506534
Subcutaneous abscess 21.79 10.71 32 64754 3412 29506329
Stiff person syndrome 21.74 10.71 8 64778 83 29509658
Narcotic bowel syndrome 21.66 10.71 9 64777 132 29509609
Herpes simplex hepatitis 21.57 10.71 8 64778 85 29509656
Growth retardation 21.51 10.71 22 64764 1614 29508127
Stevens-Johnson syndrome 21.26 10.71 5 64781 16492 29493249
Metabolic acidosis 21.18 10.71 31 64755 37631 29472110
Viral infection 21.15 10.71 76 64710 14734 29495007
Cutaneous leishmaniasis 21.12 10.71 10 64776 203 29509538
Myasthenia gravis 20.99 10.71 30 64756 3121 29506620
Congenital oesophageal anomaly 20.93 10.71 8 64778 93 29509648
Oesophageal atresia 20.92 10.71 13 64773 460 29509281
Hyperkalaemia 20.84 10.71 67 64719 61325 29448416
Pyoderma gangrenosum 20.76 10.71 18 64768 1071 29508670
Subdural haematoma 20.69 10.71 7 64779 18186 29491555
Coronary artery disease 20.60 10.71 41 64745 44149 29465592
Osteoporosis 20.55 10.71 61 64725 10708 29499033
Laryngeal mass 20.41 10.71 6 64780 28 29509713
Congenital cystic lung 20.39 10.71 10 64776 220 29509521
Lymphocytic infiltration 20.33 10.71 14 64772 591 29509150
Heart rate decreased 20.32 10.71 108 64678 24804 29484937
Combined immunodeficiency 20.30 10.71 7 64779 59 29509682
Angioedema 20.27 10.71 24 64762 31891 29477850
Immunosuppressant drug level increased 20.27 10.71 37 64749 4728 29505013
Suicide attempt 20.26 10.71 27 64759 34083 29475658
Rhabdomyolysis 20.20 10.71 67 64719 60741 29449000
Haemolysis 20.07 10.71 46 64740 6910 29502831
Ileal ulcer 19.63 10.71 13 64773 514 29509227
Gastrointestinal stoma complication 19.62 10.71 18 64768 1154 29508587
Hepatic enzyme increased 19.56 10.71 134 64652 33665 29476076
Odynophagia 19.53 10.71 36 64750 4634 29505107
Paracoccidioides infection 19.43 10.71 7 64779 68 29509673
Central nervous system lesion 19.31 10.71 40 64746 5608 29504133
Amnesia 19.20 10.71 13 64773 22630 29487111
Iron deficiency 19.12 10.71 28 64758 2977 29506764
Autoimmune haemolytic anaemia 19.12 10.71 32 64754 3816 29505925
Cytomegalovirus test positive 19.10 10.71 30 64756 3393 29506348
Gastrointestinal mucosa hyperaemia 19.05 10.71 10 64776 255 29509486
Cytokine release syndrome 18.97 10.71 3 64783 13116 29496625
Large intestinal ulcer 18.96 10.71 21 64765 1688 29508053
Gastrointestinal stenosis 18.90 10.71 7 64779 74 29509667
Mucocutaneous leishmaniasis 18.82 10.71 7 64779 75 29509666
Hypersensitivity vasculitis 18.81 10.71 29 64757 3228 29506513
Gallbladder polyp 18.78 10.71 11 64775 349 29509392
Cardiac disorder 18.76 10.71 33 64753 37230 29472511
Granuloma 18.72 10.71 25 64761 2439 29507302
Autoimmune neutropenia 18.70 10.71 10 64776 265 29509476
Anal cancer 18.67 10.71 11 64775 353 29509388
Pneumonia cytomegaloviral 18.55 10.71 26 64760 2656 29507085
Chorioretinopathy 18.54 10.71 19 64767 1397 29508344
Episcleritis 18.51 10.71 8 64778 130 29509611
Full blood count decreased 18.45 10.71 6 64780 15986 29493755
Retinal scar 18.40 10.71 10 64776 274 29509467
Herpes simplex test positive 18.22 10.71 9 64777 201 29509540
Hodgkin's disease 18.13 10.71 15 64771 837 29508904
Pseudopolyp 18.10 10.71 9 64777 204 29509537
Pancreatitis acute 18.07 10.71 103 64683 24282 29485459
Diabetes mellitus 18.02 10.71 149 64637 39682 29470059
Pneumatosis intestinalis 18.00 10.71 28 64758 3141 29506600
Polyomavirus-associated nephropathy 17.90 10.71 29 64757 3367 29506374
Blood creatine phosphokinase increased 17.86 10.71 39 64747 40605 29469136
Pulmonary granuloma 17.74 10.71 18 64768 1308 29508433
Butterfly rash 17.54 10.71 7 64779 92 29509649
Gastroenteritis clostridial 17.52 10.71 9 64777 219 29509522
Arthritis 17.45 10.71 104 64682 24915 29484826
Chest pain 17.42 10.71 159 64627 111814 29397927
Haematuria 17.29 10.71 45 64741 44094 29465647
Relapsing fever 17.28 10.71 8 64778 154 29509587
Brain abscess 17.28 10.71 25 64761 2630 29507111
Disturbance in attention 17.25 10.71 13 64773 21411 29488330
Rectal cancer 17.22 10.71 21 64765 1871 29507870
Erectile dysfunction 17.16 10.71 9 64777 18000 29491741
Aspartate aminotransferase increased 17.08 10.71 70 64716 59655 29450086
Drug specific antibody absent 17.06 10.71 6 64780 54 29509687
Weight increased 17.06 10.71 249 64537 76418 29433323
Drug ineffective for unapproved indication 17.05 10.71 69 64717 14145 29495596
Platelet count decreased 17.00 10.71 147 64639 104525 29405216
Cytomegalovirus duodenitis 16.96 10.71 6 64780 55 29509686
Depression 16.93 10.71 113 64673 85034 29424707
Intestinal ulcer 16.92 10.71 14 64772 781 29508960
Lactic acidosis 16.91 10.71 25 64761 30222 29479519
Laser therapy 16.85 10.71 4 64782 6 29509735
Intestinal diaphragm disease 16.78 10.71 9 64777 240 29509501
Serum sickness 16.74 10.71 20 64766 1745 29507996
Cryptococcosis 16.70 10.71 21 64765 1931 29507810
Hyperglycaemia 16.69 10.71 31 64755 34256 29475485
Oesophagopleural fistula 16.68 10.71 6 64780 58 29509683
Splenic embolism 16.65 10.71 8 64778 168 29509573
Hemivertebra 16.64 10.71 7 64779 106 29509635
Mental status changes 16.63 10.71 32 64754 34895 29474846
Testicular cancer metastatic 16.50 10.71 6 64780 60 29509681
Acne 16.45 10.71 51 64735 9169 29500572
Cytomegalovirus syndrome 16.41 10.71 7 64779 110 29509631
Gastrointestinal obstruction 16.26 10.71 13 64773 691 29509050
Marrow hyperplasia 16.17 10.71 15 64771 976 29508765
Injection site pain 16.09 10.71 29 64757 32417 29477324
Dyspnoea exertional 16.05 10.71 35 64751 36455 29473286
Neutropenia 16.04 10.71 198 64588 131513 29378228
Haemorrhage intracranial 15.84 10.71 6 64780 14536 29495205
Proctocolectomy 15.75 10.71 6 64780 69 29509672
Gastric fistula 15.67 10.71 6 64780 70 29509671
Cryptococcal cutaneous infection 15.67 10.71 6 64780 70 29509671
Viral test positive 15.53 10.71 8 64778 196 29509545
Arrhythmia 15.52 10.71 28 64758 31285 29478456
Anorectal stenosis 15.51 10.71 4 64782 10 29509731
Cardiac myxoma 15.51 10.71 4 64782 10 29509731
Aplasia pure red cell 15.50 10.71 36 64750 5455 29504286
Peripheral T-cell lymphoma unspecified stage IV 15.43 10.71 5 64781 34 29509707
Urinary tract infection 15.42 10.71 94 64692 72260 29437481
Spermatozoa progressive motility decreased 15.40 10.71 7 64779 129 29509612
Aqueductal stenosis 15.38 10.71 3 64783 0 29509741
Uveal melanoma 15.38 10.71 3 64783 0 29509741
Dry mouth 15.37 10.71 15 64771 21769 29487972
Disseminated cytomegaloviral infection 15.34 10.71 8 64778 201 29509540
Proctitis 15.34 10.71 21 64765 2098 29507643
Aphthous ulcer 15.33 10.71 30 64756 4038 29505703
Tuberculosis gastrointestinal 15.31 10.71 8 64778 202 29509539
Skin cancer 15.25 10.71 47 64739 8421 29501320
Pneumoperitoneum 15.21 10.71 18 64768 1555 29508186
Ejection fraction decreased 15.20 10.71 8 64778 15970 29493771
Listeriosis 15.18 10.71 14 64772 904 29508837
Sideroblastic anaemia 15.03 10.71 8 64778 210 29509531
Anal stenosis 14.97 10.71 7 64779 138 29509603
Skin lesion 14.79 10.71 80 64706 18492 29491249
Sleep disorder 14.79 10.71 19 64767 24367 29485374
Infectious mononucleosis 14.68 10.71 11 64775 531 29509210
Intentional product misuse 14.63 10.71 34 64752 34627 29475114
Coloboma 14.61 10.71 7 64779 146 29509595
Urinary incontinence 14.61 10.71 9 64777 16472 29493269
Extrapyramidal disorder 14.53 10.71 3 64783 10828 29498913
Meconium peritonitis 14.52 10.71 4 64782 14 29509727
Herpes simplex colitis 14.52 10.71 4 64782 14 29509727
Respiratory tract infection fungal 14.51 10.71 12 64774 669 29509072
Anaplastic large cell lymphoma T- and null-cell types 14.50 10.71 6 64780 87 29509654
Memory impairment 14.43 10.71 37 64749 36433 29473308
Epstein-Barr viraemia 14.42 10.71 14 64772 964 29508777
Acute pulmonary histoplasmosis 14.40 10.71 7 64779 151 29509590
Hepatitis B 14.39 10.71 35 64751 5462 29504279
Metastases to lymph nodes 14.39 10.71 29 64757 3988 29505753
Optic neuritis 14.32 10.71 25 64761 3084 29506657
Ventricular tachycardia 14.31 10.71 17 64769 22557 29487184
Lymph node tuberculosis 14.28 10.71 10 64776 434 29509307
Pulmonary nocardiosis 14.24 10.71 11 64775 556 29509185
Therapy non-responder 14.18 10.71 116 64670 30795 29478946
Dementia 14.13 10.71 4 64782 11654 29498087
Mycobacterium kansasii infection 14.12 10.71 8 64778 238 29509503
Tender joint count increased 14.12 10.71 5 64781 46 29509695
Neoplasm progression 14.10 10.71 12 64774 18600 29491141
Haemophilus bacteraemia 14.10 10.71 4 64782 16 29509725
Pulmonary paracoccidioidomycosis 14.10 10.71 4 64782 16 29509725
Mycobacterium abscessus infection 14.08 10.71 10 64776 444 29509297
Functional gastrointestinal disorder 14.07 10.71 20 64766 2070 29507671
Rectal discharge 14.07 10.71 7 64779 159 29509582
Jejunal stenosis 14.02 10.71 5 64781 47 29509694
Small intestinal ulcer haemorrhage 14.02 10.71 5 64781 47 29509694
Drug tolerance decreased 14.01 10.71 16 64770 1330 29508411
Neonatal respiratory failure 14.00 10.71 9 64777 338 29509403
Prostatic specific antigen increased 14.00 10.71 5 64781 12559 29497182
Disseminated cryptococcosis 13.98 10.71 15 64771 1163 29508578
Nausea 13.95 10.71 506 64280 288749 29220992
Neoplasm skin 13.87 10.71 11 64775 578 29509163
Migraine 13.86 10.71 59 64727 12371 29497370
Vitamin B1 decreased 13.82 10.71 8 64778 248 29509493
Intentional self-injury 13.81 10.71 5 64781 12456 29497285
Thrombocytopenia 13.78 10.71 210 64576 134613 29375128
Pruritus 13.72 10.71 177 64609 116672 29393069
Skin papilloma 13.68 10.71 18 64768 1731 29508010
Hypervolaemia 13.68 10.71 11 64775 17534 29492207
Unevaluable event 13.65 10.71 28 64758 29823 29479918
Uveitis 13.62 10.71 36 64750 5911 29503830
Campylobacter gastroenteritis 13.56 10.71 12 64774 734 29509007
Necrotising herpetic retinopathy 13.55 10.71 4 64782 19 29509722
Enterovesical fistula 13.45 10.71 11 64775 604 29509137
Peritoneal candidiasis 13.38 10.71 4 64782 20 29509721
Hepatobiliary cancer 13.31 10.71 3 64783 3 29509738
Precursor T-lymphoblastic lymphoma/leukaemia stage I 13.31 10.71 3 64783 3 29509738
Hepatic angiosarcoma 13.31 10.71 3 64783 3 29509738
Leiomyoma 13.31 10.71 3 64783 3 29509738
Leiomyosarcoma metastatic 13.31 10.71 3 64783 3 29509738
Blood bilirubin decreased 13.29 10.71 8 64778 267 29509474
Aspiration 13.29 10.71 3 64783 10177 29499564
Olfactory nerve disorder 13.22 10.71 4 64782 21 29509720
Vomiting 13.20 10.71 359 64427 211901 29297840
Overgrowth bacterial 13.18 10.71 6 64780 111 29509630
Hyperhidrosis 13.16 10.71 85 64701 64455 29445286
Skin hyperpigmentation 13.16 10.71 23 64763 2841 29506900
Haematemesis 13.14 10.71 21 64765 24605 29485136
Pain 13.12 10.71 281 64505 171151 29338590
Hepatitis cholestatic 13.11 10.71 39 64747 6854 29502887
Pneumocystis jirovecii infection 13.07 10.71 16 64770 1432 29508309
Small intestine carcinoma 13.00 10.71 10 64776 502 29509239
Oropharyngeal pain 12.95 10.71 109 64677 29176 29480565
Brachycephaly 12.94 10.71 5 64781 60 29509681
Diffuse large B-cell lymphoma stage III 12.94 10.71 5 64781 60 29509681
Gastrointestinal scarring 12.94 10.71 6 64780 116 29509625
Pulmonary oedema 12.91 10.71 49 64737 42686 29467055
Oropharyngeal squamous cell carcinoma 12.87 10.71 7 64779 192 29509549
Cholangitis chronic 12.84 10.71 3 64783 4 29509737
Arthropathy 12.79 10.71 86 64700 21468 29488273
Epstein-Barr virus antibody positive 12.78 10.71 8 64778 287 29509454
Posterior reversible encephalopathy syndrome 12.76 10.71 46 64740 8930 29500811
Gastrointestinal oedema 12.76 10.71 15 64771 1286 29508455
Poor venous access 12.76 10.71 24 64762 3137 29506604
Small intestine adenocarcinoma 12.75 10.71 6 64780 120 29509621
Pseudolymphoma 12.75 10.71 10 64776 517 29509224
Human ehrlichiosis 12.74 10.71 7 64779 196 29509545
Myelitis transverse 12.73 10.71 13 64773 952 29508789
Skin laceration 12.72 10.71 53 64733 11009 29498732
Brain stem syndrome 12.70 10.71 9 64777 398 29509343
Rash maculo-papular 12.69 10.71 21 64765 24268 29485473
Fluid retention 12.66 10.71 20 64766 23540 29486201
Henoch-Schonlein purpura 12.62 10.71 15 64771 1301 29508440
Appendicectomy 12.61 10.71 12 64774 806 29508935
Altered state of consciousness 12.58 10.71 15 64771 19874 29489867
Cognitive disorder 12.58 10.71 20 64766 23479 29486262
Diaphragmatic injury 12.57 10.71 6 64780 124 29509617
Antiphospholipid syndrome 12.56 10.71 9 64777 405 29509336
Cytomegalovirus oesophagitis 12.52 10.71 9 64777 407 29509334
Oedema 12.50 10.71 46 64740 40437 29469304
Drug interaction 12.49 10.71 333 64453 197052 29312689
Accidental exposure to product 12.47 10.71 4 64782 10749 29498992
Diarrhoea 12.45 10.71 599 64187 332099 29177642
Microscopic polyangiitis 12.44 10.71 6 64780 127 29509614
Placental disorder 12.44 10.71 5 64781 67 29509674
Lymphocyte count 12.44 10.71 5 64781 67 29509674
Polydipsia 12.39 10.71 25 64761 3440 29506301
Colonic abscess 12.37 10.71 9 64777 415 29509326
Caesarean section 12.36 10.71 18 64768 1905 29507836
Leiomyosarcoma 12.27 10.71 6 64780 131 29509610
Toxic epidermal necrolysis 12.24 10.71 13 64773 18140 29491601
Short-bowel syndrome 12.18 10.71 7 64779 214 29509527
Vision blurred 12.18 10.71 46 64740 40130 29469611
Musculoskeletal discomfort 12.18 10.71 36 64750 6305 29503436
Lip swelling 12.12 10.71 6 64780 12404 29497337
Antibody test abnormal 12.11 10.71 6 64780 135 29509606
Anaplastic large cell lymphoma T- and null-cell types stage III 12.10 10.71 3 64783 6 29509735
Protein deficiency 12.10 10.71 3 64783 6 29509735
Actinic cheilitis 12.10 10.71 3 64783 6 29509735
Alternaria infection 12.02 10.71 8 64778 319 29509422
Gastrointestinal cancer metastatic 11.99 10.71 5 64781 74 29509667
Pneumonia legionella 11.87 10.71 16 64770 1575 29508166
Blood sodium decreased 11.84 10.71 9 64777 14758 29494983
Muscle rigidity 11.84 10.71 3 64783 9408 29500333
Eosinophilic myocarditis 11.80 10.71 9 64777 446 29509295
Alanine aminotransferase increased 11.79 10.71 99 64687 70845 29438896
Central nervous system lymphoma 11.76 10.71 11 64775 723 29509018
Death neonatal 11.76 10.71 8 64778 331 29509410
Focal segmental glomerulosclerosis 11.74 10.71 17 64769 1790 29507951
Haemodialysis 11.69 10.71 48 64738 9906 29499835
Neurological symptom 11.68 10.71 24 64762 3346 29506395
Chronic graft versus host disease in liver 11.63 10.71 8 64778 337 29509404
Scar 11.61 10.71 32 64754 5387 29504354
Adenocarcinoma 11.61 10.71 16 64770 1609 29508132
Vasculitis necrotising 11.54 10.71 10 64776 595 29509146
Hair follicle tumour benign 11.50 10.71 3 64783 8 29509733
Lymphadenopathy 11.48 10.71 94 64692 24955 29484786
Adverse drug reaction 11.44 10.71 22 64764 23998 29485743
Testis cancer 11.43 10.71 12 64774 908 29508833
Diabetic ketoacidosis 11.42 10.71 11 64775 16062 29493679
Gastrointestinal stoma output decreased 11.37 10.71 4 64782 36 29509705
Food intolerance 11.37 10.71 13 64773 1082 29508659
Peritoneal tuberculosis 11.30 10.71 8 64778 353 29509388
American trypanosomiasis 11.28 10.71 7 64779 247 29509494
Withdrawal syndrome 11.22 10.71 5 64781 10987 29498754
Underdose 11.21 10.71 6 64780 11863 29497878
Rhegmatogenous retinal detachment 11.18 10.71 4 64782 38 29509703
Opportunistic infection 11.15 10.71 15 64771 1474 29508267
Product administration error 11.12 10.71 9 64777 14301 29495440
Enterostomy 11.10 10.71 5 64781 90 29509651
Congenital arterial malformation 11.10 10.71 5 64781 90 29509651
Liver disorder 11.08 10.71 101 64685 27648 29482093
Complications of transplanted heart 11.08 10.71 7 64779 255 29509486
Sacroiliitis 11.07 10.71 13 64773 1114 29508627
Diaphragmatic hernia 11.06 10.71 7 64779 256 29509485
Acute respiratory failure 11.06 10.71 26 64760 26376 29483365
Anger 11.05 10.71 5 64781 10885 29498856
Dysarthria 11.00 10.71 33 64753 30878 29478863
Angina unstable 11.00 10.71 5 64781 10860 29498881
Perineal fistula 11 10.71 3 64783 10 29509731
Foetal cardiac disorder 11 10.71 3 64783 10 29509731
Mediastinum neoplasm 11 10.71 3 64783 10 29509731
Hodgkin's disease nodular sclerosis 11 10.71 3 64783 10 29509731
Ophthalmic herpes simplex 10.99 10.71 7 64779 259 29509482
Drug specific antibody 10.99 10.71 7 64779 259 29509482
Xanthoma 10.96 10.71 5 64781 93 29509648
Ageusia 10.95 10.71 3 64783 8935 29500806
Stenotrophomonas infection 10.93 10.71 16 64770 1701 29508040
Back pain 10.90 10.71 158 64628 102126 29407615
Anorectal disorder 10.87 10.71 12 64774 961 29508780
Rectal stenosis 10.86 10.71 6 64780 170 29509571
Restlessness 10.80 10.71 20 64766 22125 29487616
Immunosuppressant drug level decreased 10.78 10.71 13 64773 1145 29508596
Bile duct stenosis 10.76 10.71 13 64773 1147 29508594
Hepatitis chronic active 10.74 10.71 4 64782 43 29509698

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Off label use 931.34 9.77 3373 144871 629433 63721055
Drug ineffective 701.49 9.77 3780 144464 836467 63514021
Colitis ulcerative 541.05 9.77 438 147806 22590 64327898
Completed suicide 471.23 9.77 9 148235 224405 64126083
Post transplant lymphoproliferative disorder 395.13 9.77 256 147988 9288 64341200
Cytomegalovirus infection 371.70 9.77 443 147801 36756 64313732
Death 362.28 9.77 346 147898 482359 63868129
Exposure during pregnancy 358.91 9.77 642 147602 77033 64273455
Treatment failure 356.12 9.77 812 147432 116004 64234484
Intentional product use issue 312.06 9.77 682 147562 94682 64255806
Intestinal stenosis 309.09 9.77 150 148094 3064 64347424
Product use in unapproved indication 306.88 9.77 998 147246 175620 64174868
Fall 305.39 9.77 305 147939 416521 63933967
Condition aggravated 305.02 9.77 1671 146573 370755 63979733
Epstein-Barr virus infection 296.41 9.77 239 148005 12249 64338239
Product use issue 266.83 9.77 861 147383 150854 64199634
Hepatosplenic T-cell lymphoma 263.51 9.77 91 148153 731 64349757
Disease recurrence 244.64 9.77 331 147913 31179 64319309
Drug abuse 241.41 9.77 16 148228 132358 64218130
Diffuse large B-cell lymphoma 238.95 9.77 195 148049 10166 64340322
Toxicity to various agents 237.53 9.77 292 147952 363221 63987267
Cushingoid 232.04 9.77 169 148075 7434 64343054
Drug level below therapeutic 231.89 9.77 167 148077 7217 64343271
Fistula 221.52 9.77 182 148062 9579 64340909
Frequent bowel movements 216.63 9.77 238 148006 18067 64332421
Drug intolerance 216.60 9.77 931 147313 187061 64163427
Anal abscess 206.99 9.77 157 148087 7351 64343137
Haemophagocytic lymphohistiocytosis 206.74 9.77 228 148016 17381 64333107
Premature delivery 205.07 9.77 233 148011 18356 64332132
Anal fistula 203.05 9.77 135 148109 5118 64345370
Hypotension 192.12 9.77 365 147879 380609 63969879
Lymphoproliferative disorder 189.69 9.77 128 148116 4975 64345513
Maternal exposure during pregnancy 186.77 9.77 564 147680 95320 64255168
Nodular regenerative hyperplasia 184.47 9.77 71 148173 799 64349689
Ileal stenosis 184.45 9.77 92 148152 1998 64348490
Faecal calprotectin increased 181.79 9.77 110 148134 3530 64346958
Drug eruption 180.20 9.77 309 147935 35827 64314661
Inappropriate schedule of product administration 177.08 9.77 540 147704 91746 64258742
Transplant rejection 175.04 9.77 208 148036 17193 64333295
Disseminated tuberculosis 171.42 9.77 106 148138 3539 64346949
Febrile neutropenia 163.31 9.77 116 148128 187541 64162947
Kidney transplant rejection 162.74 9.77 151 148093 9360 64341128
Malignant neoplasm progression 162.74 9.77 31 148213 112840 64237648
SLE arthritis 162.19 9.77 57 148187 485 64350003
Epstein-Barr virus associated lymphoproliferative disorder 160.28 9.77 96 148148 3023 64347465
Confusional state 159.90 9.77 220 148024 260924 64089564
Squamous cell carcinoma 158.38 9.77 177 148067 13692 64336796
Hyponatraemia 154.14 9.77 74 148170 148265 64202223
Lupus-like syndrome 151.25 9.77 140 148104 8651 64341837
Somnolence 151.16 9.77 147 148097 203498 64146990
Blood pressure fluctuation 148.50 9.77 352 147892 51519 64298969
Atrial fibrillation 145.94 9.77 108 148136 170981 64179507
Progressive multifocal leukoencephalopathy 145.28 9.77 194 148050 18038 64332450
Therapeutic response decreased 143.86 9.77 349 147895 51839 64298649
Pancytopenia 142.71 9.77 680 147564 142629 64207859
Bone erosion 141.09 9.77 153 148091 11442 64339046
Pneumocystis jirovecii pneumonia 140.02 9.77 238 148006 27396 64323092
Basal cell carcinoma 139.91 9.77 253 147991 30585 64319903
Cytomegalovirus colitis 135.29 9.77 94 148150 3834 64346654
Overdose 134.45 9.77 102 148142 159464 64191024
Therapeutic product effect incomplete 132.80 9.77 530 147714 102952 64247536
Intestinal obstruction 131.89 9.77 271 147973 36015 64314473
Intestinal resection 131.19 9.77 84 148160 2984 64347504
Large intestinal stenosis 130.42 9.77 77 148167 2360 64348128
Therapeutic product effect decreased 130.21 9.77 568 147676 114783 64235705
Vasculitis 129.80 9.77 183 148061 17912 64332576
Cholestasis of pregnancy 129.32 9.77 56 148188 869 64349619
Cardiac failure congestive 128.41 9.77 70 148174 130510 64219978
Dizziness 123.99 9.77 538 147706 429625 63920863
Demyelination 121.79 9.77 111 148133 6723 64343765
B-cell lymphoma 120.17 9.77 100 148144 5357 64345131
Cardio-respiratory arrest 118.72 9.77 39 148205 98354 64252134
Haematochezia 117.72 9.77 378 147866 65995 64284493
Cytomegalovirus viraemia 116.52 9.77 134 148110 10694 64339794
Lung transplant rejection 115.68 9.77 58 148186 1274 64349214
Intentional overdose 115.13 9.77 32 148212 89912 64260576
Abscess 115.11 9.77 179 148065 19125 64331363
Syncope 113.26 9.77 117 148127 157518 64192970
Drug level decreased 113.22 9.77 136 148108 11367 64339121
Pulmonary tuberculosis 112.49 9.77 109 148135 7135 64343353
Elbow deformity 112.07 9.77 56 148188 1221 64349267
Acute kidney injury 110.21 9.77 595 147649 448645 63901843
Bradycardia 109.66 9.77 68 148176 118151 64232337
Abdominal pain 108.47 9.77 1146 147098 311229 64039259
Electrocardiogram QT prolonged 104.08 9.77 27 148217 79421 64271067
Hypokalaemia 103.87 9.77 77 148167 121826 64228662
Dyspnoea 102.37 9.77 1108 147136 717566 63632922
Leukopenia 101.91 9.77 482 147762 100760 64249728
Proteinuria 101.87 9.77 208 148036 27515 64322973
Cardiac arrest 101.22 9.77 123 148121 153941 64196547
Blood iron abnormal 99.04 9.77 50 148194 1115 64349373
Premature labour 98.81 9.77 104 148140 7516 64342972
Drug specific antibody present 98.34 9.77 87 148157 5067 64345421
Loss of consciousness 97.95 9.77 118 148126 148247 64202241
Colectomy 97.74 9.77 66 148178 2568 64347920
Clostridium difficile infection 97.69 9.77 240 148004 35923 64314565
Histoplasmosis disseminated 96.24 9.77 59 148185 1939 64348549
Rheumatoid arthritis 96.15 9.77 677 147567 163617 64186871
Tuberculosis 95.21 9.77 133 148111 12905 64337583
Red blood cell sedimentation rate increased 94.90 9.77 217 148027 31018 64319470
Clear cell renal cell carcinoma 94.01 9.77 60 148184 2119 64348369
Hypoglycaemia 93.11 9.77 45 148199 89847 64260641
Lupus nephritis 92.97 9.77 62 148182 2362 64348126
Diarrhoea haemorrhagic 91.81 9.77 121 148123 11106 64339382
Fatigue 91.76 9.77 1193 147051 747537 63602951
Erythema nodosum 91.57 9.77 75 148169 3929 64346559
Epstein-Barr virus test positive 91.24 9.77 45 148199 953 64349535
Product dose omission issue 90.79 9.77 195 148049 194552 64155936
Decreased appetite 88.98 9.77 339 147905 280950 64069538
Intestinal fistula 87.98 9.77 47 148197 1182 64349306
JC virus infection 87.75 9.77 68 148176 3287 64347201
Kaposi's sarcoma 87.55 9.77 40 148204 709 64349779
Myocardial infarction 86.84 9.77 155 148089 165666 64184822
Scleritis 86.15 9.77 64 148180 2902 64347586
Acute febrile neutrophilic dermatosis 86.04 9.77 67 148177 3262 64347226
Antinuclear antibody positive 85.89 9.77 88 148156 6162 64344326
Insomnia 85.81 9.77 206 148038 197630 64152858
Neutrophil count decreased 85.68 9.77 35 148209 77161 64273327
Arthritis 85.04 9.77 400 147844 83414 64267074
Squamous cell carcinoma of skin 85.02 9.77 120 148124 11756 64338732
Coma 84.62 9.77 48 148196 87567 64262921
Hepatic function abnormal 84.57 9.77 332 147912 63981 64286507
Histoplasmosis 83.10 9.77 54 148190 1968 64348520
C-reactive protein increased 82.85 9.77 434 147810 94475 64256013
Normal newborn 82.52 9.77 82 148162 5535 64344953
Asthenia 82.24 9.77 611 147633 427433 63923055
Sedation 81.95 9.77 3 148241 41459 64309029
Anal fissure 81.82 9.77 77 148167 4859 64345629
Cerebrovascular accident 81.05 9.77 119 148125 137464 64213024
Immunosuppression 80.53 9.77 111 148133 10635 64339853
Abortion spontaneous 80.09 9.77 178 148066 24965 64325523
Mycobacterial infection 79.11 9.77 61 148183 2927 64347561
Pre-eclampsia 78.94 9.77 84 148160 6147 64344341
Chronic allograft nephropathy 78.64 9.77 47 148197 1474 64349014
Arthralgia 77.58 9.77 1437 146807 440823 63909665
Dehydration 77.42 9.77 248 147996 216515 64133973
Nocardiosis 76.42 9.77 73 148171 4694 64345794
Granulomatosis with polyangiitis 76.00 9.77 52 148192 2068 64348420
Gastrointestinal inflammation 75.82 9.77 82 148162 6113 64344375
Renal cell carcinoma 75.06 9.77 81 148163 6023 64344465
Gastrointestinal lymphoma 74.41 9.77 23 148221 124 64350364
Respiratory arrest 73.34 9.77 16 148228 52969 64297519
T-cell lymphoma 72.55 9.77 41 148203 1155 64349333
Epidermodysplasia verruciformis 72.47 9.77 24 148220 167 64350321
Osteoporosis 72.20 9.77 237 148007 41843 64308645
Impaired gastric emptying 72.17 9.77 95 148149 8709 64341779
Contusion 71.70 9.77 94 148150 113871 64236617
Therapeutic response shortened 71.67 9.77 102 148142 10068 64340420
Weight decreased 70.97 9.77 984 147260 284755 64065733
Inflammation 70.95 9.77 318 147926 64982 64285506
Constipation 70.18 9.77 280 147964 229057 64121431
Coombs positive haemolytic anaemia 69.75 9.77 36 148208 842 64349646
Hair follicle tumour benign 69.66 9.77 29 148215 406 64350082
Blood glucose increased 69.06 9.77 74 148170 97999 64252489
Depressed level of consciousness 68.63 9.77 52 148192 81384 64269104
Human herpesvirus 8 infection 68.40 9.77 38 148206 1035 64349453
Colitis 67.75 9.77 291 147953 58383 64292105
Synovial fluid analysis 67.19 9.77 43 148201 1526 64348962
Hyperkalaemia 67.19 9.77 80 148164 101049 64249439
Heart transplant rejection 67.14 9.77 40 148204 1247 64349241
Gestational hypertension 66.90 9.77 44 148200 1637 64348851
Bone marrow failure 65.86 9.77 251 147993 47701 64302787
Lymphopenia 65.85 9.77 167 148077 25490 64324998
Diabetes mellitus 65.79 9.77 315 147929 66159 64284329
Pneumonia aspiration 65.57 9.77 27 148217 59244 64291244
Tenosynovitis stenosans 65.39 9.77 46 148198 1914 64348574
Orthostatic hypotension 64.92 9.77 14 148230 46724 64303764
Epstein-Barr virus associated lymphoma 64.89 9.77 35 148209 898 64349590
Chronic obstructive pulmonary disease 64.32 9.77 42 148202 71006 64279482
Cholangitis sclerosing 63.94 9.77 45 148199 1874 64348614
Platelet count decreased 63.33 9.77 187 148057 167524 64182964
Extrapulmonary tuberculosis 63.31 9.77 26 148218 351 64350137
Agitation 62.98 9.77 66 148178 88301 64262187
Inflammatory bowel disease 62.55 9.77 64 148180 4474 64346014
Hypogammaglobulinaemia 62.10 9.77 96 148148 10203 64340285
Hallucination 61.95 9.77 46 148198 72742 64277746
Aspergillus infection 61.49 9.77 124 148120 16255 64334233
Plasmablastic lymphoma 61.26 9.77 26 148218 383 64350105
Wrong technique in product usage process 60.75 9.77 37 148207 64937 64285551
Small intestinal stenosis 60.58 9.77 30 148214 641 64349847
Serotonin syndrome 60.56 9.77 9 148235 39273 64311215
Papilloma viral infection 59.93 9.77 39 148205 1425 64349063
Infusion related reaction 59.62 9.77 609 147635 163858 64186630
Varicella zoster virus infection 59.42 9.77 58 148186 3830 64346658
Immunosuppressant drug level decreased 59.17 9.77 42 148202 1773 64348715
Pain 59.10 9.77 906 147338 552605 63797883
Seizure 58.83 9.77 192 148052 166700 64183788
Balance disorder 58.34 9.77 64 148180 83862 64266626
Listeriosis 58.32 9.77 43 148201 1927 64348561
Crohn's disease 57.96 9.77 43 148201 1946 64348542
Rheumatoid nodule 57.64 9.77 104 148140 12547 64337941
Acute myocardial infarction 56.88 9.77 46 148198 69672 64280816
Drug tolerance decreased 56.57 9.77 75 148169 6923 64343565
Tremor 56.17 9.77 165 148079 148065 64202423
Anxiety 56.10 9.77 257 147987 202392 64148096
Lactic acidosis 56.00 9.77 36 148208 61374 64289114
Oedema peripheral 55.72 9.77 271 147973 210046 64140442
Neuropathy peripheral 55.31 9.77 117 148127 117408 64233080
Aphthous ulcer 54.90 9.77 103 148141 12803 64337685
Central nervous system lymphoma 54.52 9.77 41 148203 1894 64348594
Ankylosing spondylitis 54.26 9.77 80 148164 8154 64342334
Episcleritis 54.17 9.77 30 148214 812 64349676
Gastrointestinal haemorrhage 54.06 9.77 142 148102 132170 64218318
Lymphoma 52.88 9.77 106 148138 13835 64336653
Metabolic acidosis 52.85 9.77 51 148193 70907 64279581
Defaecation urgency 52.71 9.77 55 148189 3934 64346554
Unresponsive to stimuli 52.52 9.77 25 148219 50368 64300120
Hypersensitivity 52.21 9.77 685 147559 195767 64154721
International normalised ratio increased 52.19 9.77 63 148181 79104 64271384
Depression 51.60 9.77 231 148013 183060 64167428
Hepatic cirrhosis 51.44 9.77 155 148089 26143 64324345
Delirium 51.22 9.77 50 148194 69144 64281344
Cardiac failure 51.13 9.77 146 148098 132227 64218261
Palmar-plantar erythrodysaesthesia syndrome 51.02 9.77 4 148240 28815 64321673
Strongyloidiasis 50.83 9.77 48 148196 3042 64347446
Actinic keratosis 50.72 9.77 61 148183 5104 64345384
Hepatosplenomegaly 50.68 9.77 62 148182 5281 64345207
Injection site swelling 50.56 9.77 16 148228 41337 64309151
Lupus vasculitis 50.46 9.77 24 148220 468 64350020
Dyskinesia 50.42 9.77 14 148230 39374 64311114
Red blood cell sedimentation rate abnormal 50.32 9.77 114 148130 16192 64334296
Liver transplant rejection 50.12 9.77 47 148197 2952 64347536
Small intestinal obstruction 49.99 9.77 143 148101 23430 64327058
Immunosuppressant drug level increased 49.97 9.77 72 148172 7187 64343301
Autoimmune hepatitis 49.95 9.77 86 148158 9998 64340490
Back pain 49.45 9.77 354 147890 249817 64100671
Urinary retention 48.89 9.77 26 148218 49175 64301313
Peliosis hepatis 48.82 9.77 15 148229 79 64350409
Intentional self-injury 48.81 9.77 5 148239 29039 64321449
Heart rate irregular 48.47 9.77 156 148088 27257 64323231
Transplant dysfunction 48.34 9.77 68 148176 6640 64343848
Retinitis 47.56 9.77 39 148205 2046 64348442
White blood cell count decreased 47.44 9.77 194 148050 157643 64192845
Suicide attempt 47.34 9.77 56 148188 70951 64279537
Pneumonia cytomegaloviral 47.19 9.77 54 148190 4285 64346203
Accidental overdose 46.71 9.77 10 148234 33547 64316941
Mycobacterium abscessus infection 46.45 9.77 29 148215 985 64349503
Body temperature fluctuation 46.34 9.77 47 148197 3251 64347237
Enterocutaneous fistula 46.13 9.77 34 148210 1523 64348965
Intentional product misuse 46.11 9.77 59 148185 72236 64278252
Injection site erythema 45.97 9.77 57 148187 70743 64279745
Non-cirrhotic portal hypertension 45.87 9.77 21 148223 374 64350114
Subcutaneous abscess 45.72 9.77 68 148176 6985 64343503
Ulcer 45.44 9.77 136 148108 22854 64327634
Meningitis listeria 45.39 9.77 26 148218 752 64349736
Abscess intestinal 45.35 9.77 40 148204 2320 64348168
Nausea 45.08 9.77 1420 146824 784380 63566108
Pyoderma gangrenosum 44.85 9.77 45 148199 3073 64347415
Live birth 44.68 9.77 87 148157 11117 64339371
Abdominal adhesions 44.55 9.77 44 148200 2948 64347540
Rheumatoid factor negative 44.45 9.77 29 148215 1064 64349424
Disseminated cytomegaloviral infection 44.41 9.77 21 148223 404 64350084
Pleuritic pain 44.04 9.77 72 148172 8024 64342464
Fungal endocarditis 43.93 9.77 22 148222 482 64350006
Therapeutic reaction time decreased 43.78 9.77 36 148208 1896 64348592
Chorioretinopathy 43.75 9.77 38 148206 2159 64348329
Pulmonary mass 43.67 9.77 138 148106 23878 64326610
Varicella 43.66 9.77 41 148203 2580 64347908
Herpes simplex hepatitis 43.49 9.77 21 148223 424 64350064
Vomiting 43.43 9.77 951 147293 550166 63800322
Herpes zoster 43.21 9.77 321 147923 78866 64271622
Sopor 43.04 9.77 8 148236 29653 64320835
Abnormal behaviour 42.94 9.77 12 148232 33610 64316878
Candida infection 42.76 9.77 164 148080 31255 64319233
Drug level above therapeutic 42.55 9.77 65 148179 6836 64343652
Hyperhidrosis 42.45 9.77 146 148098 124774 64225714
Aggression 42.29 9.77 27 148217 46205 64304283
Joint dislocation 42.09 9.77 86 148158 11379 64339109
Joint swelling 41.97 9.77 712 147532 214670 64135818
Angiocentric lymphoma 41.88 9.77 25 148219 782 64349706
Intestinal perforation 41.74 9.77 102 148142 15211 64335277
Disorientation 41.72 9.77 40 148204 55788 64294700
Intestinal anastomosis 41.69 9.77 21 148223 466 64350022
Rectal abscess 41.69 9.77 32 148212 1525 64348963
Ileostomy 41.47 9.77 29 148215 1195 64349293
Premature rupture of membranes 41.41 9.77 47 148197 3697 64346791
Myopathy 41.19 9.77 111 148133 17569 64332919
Abdominal abscess 41.18 9.77 61 148183 6243 64344245
Epicondylitis 40.92 9.77 34 148210 1817 64348671
Suicidal ideation 40.71 9.77 56 148188 66486 64284002
Panniculitis 40.46 9.77 73 148171 8806 64341682
Rebound effect 40.21 9.77 53 148191 4864 64345624
Neoplasm progression 40.18 9.77 22 148222 40942 64309546
Cytomegalovirus enteritis 40.16 9.77 23 148221 665 64349823
Drug hypersensitivity 39.60 9.77 767 147477 237048 64113440
Cutaneous T-cell lymphoma 39.58 9.77 37 148207 2315 64348173
Caesarean section 39.55 9.77 83 148161 11191 64339297
Fistula discharge 39.37 9.77 26 148218 974 64349514
Plasma cell myeloma 39.36 9.77 29 148215 46046 64304442
Neuroendocrine carcinoma of the skin 39.18 9.77 26 148218 982 64349506
Complications of transplanted kidney 39.02 9.77 55 148189 5380 64345108
Aplasia pure red cell 39.00 9.77 63 148181 6951 64343537
Injection site pain 38.67 9.77 129 148115 111279 64239209
Medication error 38.28 9.77 35 148209 49931 64300557
Mucosal inflammation 37.95 9.77 53 148191 62531 64287957
Portal hypertension 37.54 9.77 58 148186 6161 64344327
Hypocalcaemia 37.35 9.77 25 148219 41728 64308760
Myasthenia gravis crisis 37.29 9.77 24 148220 860 64349628
Brain abscess 37.22 9.77 47 148197 4134 64346354
Gastrointestinal wall thickening 37.14 9.77 34 148210 2071 64348417
Meningitis cryptococcal 37.12 9.77 40 148204 2969 64347519
Contraindicated product administered 37.03 9.77 395 147849 107434 64243054
Myasthenia gravis 36.74 9.77 55 148189 5683 64344805
Lung abscess 36.47 9.77 43 148201 3523 64346965
Legionella infection 36.41 9.77 22 148222 704 64349784
Poisoning 36.17 9.77 4 148240 21875 64328613
Lymphadenitis 36.03 9.77 44 148200 3741 64346747
Mental status changes 35.90 9.77 53 148191 61109 64289379
C-reactive protein abnormal 35.81 9.77 147 148097 28900 64321588
Osteonecrosis 35.71 9.77 144 148100 28085 64322403
Ventricular tachycardia 35.70 9.77 17 148227 34248 64316240
Pneumocystis jirovecii infection 35.67 9.77 35 148209 2326 64348162
Pancreatitis 35.62 9.77 247 147997 59360 64291128
Drug ineffective for unapproved indication 35.62 9.77 154 148090 30979 64319509
Visceral leishmaniasis 35.33 9.77 24 148220 943 64349545
Pulmonary fibrosis 35.11 9.77 149 148095 29729 64320759
Rhegmatogenous retinal detachment 34.96 9.77 13 148231 132 64350356
Mycobacterium avium complex infection 34.62 9.77 44 148200 3896 64346592
Synovitis 34.50 9.77 364 147880 98726 64251762
Glossodynia 34.27 9.77 60 148184 64636 64285852
Restlessness 34.04 9.77 25 148219 39760 64310728
Anaphylactic reaction 33.93 9.77 272 147972 68392 64282096
Malignant melanoma 33.91 9.77 85 148159 12879 64337609
Coronary artery disease 33.91 9.77 54 148190 60379 64290109
Obliterative bronchiolitis 33.89 9.77 36 148208 2629 64347859
Fluid retention 33.69 9.77 53 148191 59553 64290935
Dysgeusia 33.67 9.77 35 148209 47012 64303476
Injection site bruising 33.60 9.77 21 148223 36352 64314136
Overlap syndrome 33.59 9.77 21 148223 715 64349773
Eosinophilic granulomatosis with polyangiitis 33.28 9.77 37 148207 2845 64347643
Bronchopulmonary aspergillosis 33.19 9.77 108 148136 18977 64331511
Full blood count decreased 32.96 9.77 6 148238 22576 64327912
Angina pectoris 32.87 9.77 33 148211 45048 64305440
Hyperglycaemia 32.79 9.77 56 148188 60912 64289576
Cytomegalovirus chorioretinitis 32.77 9.77 48 148196 4864 64345624
Muscle injury 32.73 9.77 10 148234 26427 64324061
Anti-neutrophil cytoplasmic antibody positive vasculitis 32.71 9.77 37 148207 2899 64347589
Feeling abnormal 32.61 9.77 177 148067 133425 64217063
Infectious mononucleosis 32.56 9.77 29 148215 1704 64348784
Pulmonary oedema 32.45 9.77 84 148160 78590 64271898
Phospholipidosis 32.44 9.77 12 148232 120 64350368
Infection reactivation 32.37 9.77 31 148213 1999 64348489
Female genital tract fistula 32.21 9.77 35 148209 2623 64347865
Cardiac disorder 32.15 9.77 49 148195 55767 64294721
Neutropenia 32.11 9.77 374 147870 239250 64111238
Skin lesion 31.93 9.77 167 148077 36315 64314173
Anorectal stenosis 31.91 9.77 9 148235 33 64350455
Cutaneous leishmaniasis 31.89 9.77 15 148229 285 64350203
Therapeutic product effect variable 31.86 9.77 28 148216 1616 64348872
Pregnancy 31.82 9.77 113 148131 20752 64329736
Natural killer-cell leukaemia 31.36 9.77 11 148233 93 64350395
Hypomagnesaemia 31.31 9.77 24 148220 37352 64313136
Anal cancer 31.22 9.77 19 148225 616 64349872
Bone pain 31.20 9.77 38 148206 47534 64302954
Gastrointestinal fistula 31.17 9.77 19 148225 618 64349870
Cytomegalovirus test positive 31.08 9.77 48 148196 5096 64345392
Vision blurred 31.05 9.77 105 148139 90211 64260277
Cytomegalovirus infection reactivation 31.05 9.77 51 148193 5705 64344783
Blood calcium decreased 31.04 9.77 10 148234 25544 64324944
Impaired work ability 31.00 9.77 91 148153 15128 64335360
Exostosis 30.98 9.77 76 148168 11362 64339126
Accidental exposure to product 30.83 9.77 11 148233 26353 64324135
Injury 30.51 9.77 51 148193 55941 64294547
Squamous cell carcinoma of the tongue 30.44 9.77 19 148225 645 64349843
Osteonecrosis of jaw 30.38 9.77 28 148216 39797 64310691
Transient ischaemic attack 30.36 9.77 34 148210 44148 64306340
Hypervolaemia 30.31 9.77 26 148218 38259 64312229
Mycoplasma infection 30.28 9.77 19 148225 651 64349837
Complications of transplanted lung 30.18 9.77 16 148228 396 64350092
Cognitive disorder 30.18 9.77 50 148194 55037 64295451
Lymphadenopathy 30.02 9.77 197 148047 46489 64303999
Musculoskeletal stiffness 29.99 9.77 423 147821 122783 64227705
Foetal death 29.93 9.77 51 148193 5879 64344609
Crepitations 29.80 9.77 60 148184 7855 64342633
Muscle fatigue 29.77 9.77 36 148208 3029 64347459
Myelosuppression 29.69 9.77 121 148123 23709 64326779
Proctalgia 29.30 9.77 58 148186 7501 64342987
Listeria sepsis 29.05 9.77 18 148226 603 64349885
Pouchitis 29.04 9.77 20 148224 804 64349684
Irritability 29.04 9.77 25 148219 36721 64313767
Poor venous access 28.97 9.77 78 148166 12339 64338149
Rectal cancer metastatic 28.89 9.77 16 148228 433 64350055
Antiphospholipid syndrome 28.79 9.77 26 148218 1556 64348932
Lupus myocarditis 28.78 9.77 10 148234 82 64350406
Anaemia 28.75 9.77 657 147587 378023 63972465
Complications of bone marrow transplant 28.68 9.77 18 148226 617 64349871
Phaeohyphomycosis 28.59 9.77 22 148222 1052 64349436
Thrombocytopenia 28.57 9.77 353 147891 223448 64127040
Injection site inflammation 28.34 9.77 36 148208 3185 64347303
Autoimmune haemolytic anaemia 28.28 9.77 55 148189 7021 64343467
Non-Hodgkin's lymphoma 28.25 9.77 25 148219 1456 64349032
Cow pox 28.23 9.77 8 148236 30 64350458
Neoplasm malignant 28.15 9.77 122 148122 24566 64325922
Splenomegaly 28.02 9.77 98 148146 17863 64332625
Rectal fissure 27.98 9.77 19 148225 746 64349742
Multiple sclerosis relapse 27.89 9.77 32 148212 41103 64309385
Renal mass 27.89 9.77 33 148211 2714 64347774
Joint stiffness 27.88 9.77 141 148103 30263 64320225
Nicotinic acid deficiency 27.87 9.77 11 148233 133 64350355
Thiopurine methyltransferase decreased 27.86 9.77 14 148230 309 64350179
Disturbance in attention 27.80 9.77 32 148212 41042 64309446
Sinus bradycardia 27.73 9.77 9 148235 22884 64327604
Nephropathy toxic 27.70 9.77 96 148148 17418 64333070
Ganglioneuroma 27.37 9.77 11 148233 140 64350348
Skin ulcer 27.33 9.77 184 148060 43790 64306698
Polyomavirus-associated nephropathy 27.31 9.77 44 148200 4844 64345644
Melaena 27.16 9.77 51 148193 53497 64296991
Epstein Barr virus positive mucocutaneous ulcer 27.15 9.77 18 148226 679 64349809
Intestinal anastomosis complication 27.12 9.77 13 148231 258 64350230
Tuberculosis of central nervous system 27.08 9.77 15 148229 406 64350082
Opportunistic infection 27.06 9.77 32 148212 2630 64347858
Hepatitis cholestatic 27.01 9.77 75 148169 12080 64338408
Duodenal ulcer perforation 26.82 9.77 24 148220 34601 64315887
Foetal growth restriction 26.80 9.77 26 148218 1704 64348784
Inappropriate antidiuretic hormone secretion 26.58 9.77 9 148235 22280 64328208
Bronchiectasis 26.40 9.77 82 148162 14058 64336430
Intestinal mass 26.24 9.77 21 148223 1064 64349424
Device dislocation 26.24 9.77 8 148236 21170 64329318
Anaplastic large cell lymphoma T- and null-cell types 26.10 9.77 10 148234 111 64350377
Renal transplant failure 26.07 9.77 25 148219 1615 64348873
Sepsis neonatal 26.06 9.77 8 148236 42 64350446
Sleep disorder 25.99 9.77 62 148182 59647 64290841
Rectal haemorrhage 25.87 9.77 236 148008 61581 64288907
Granuloma 25.79 9.77 51 148193 6590 64343898
Serum sickness 25.50 9.77 34 148210 3155 64347333
Pulmonary vasculitis 25.46 9.77 12 148232 229 64350259
Pelvic abscess 25.39 9.77 26 148218 1819 64348669
Haematoma 25.31 9.77 42 148202 46208 64304280
Therapy non-responder 25.29 9.77 247 147997 65652 64284836
Blister 25.28 9.77 98 148146 80869 64269619
Diabetic ketoacidosis 25.21 9.77 19 148225 29826 64320662
Primary biliary cholangitis 25.20 9.77 20 148224 1001 64349487
Lung infiltration 25.19 9.77 105 148139 20784 64329704
Large intestinal ulcer 25.16 9.77 39 148205 4154 64346334
Underdose 25.15 9.77 14 148230 25815 64324673
Product quality issue 25.14 9.77 19 148225 29780 64320708
Meningoencephalitis viral 25.08 9.77 14 148230 385 64350103
Abdominal discomfort 25.02 9.77 283 147961 182039 64168449
Scleroderma renal crisis 24.98 9.77 14 148230 388 64350100
Pseudopolyp 24.95 9.77 14 148230 389 64350099
Uveitis 24.94 9.77 75 148169 12633 64337855
Dysarthria 24.83 9.77 63 148181 59343 64291145
Diffuse large B-cell lymphoma stage IV 24.82 9.77 15 148229 480 64350008
Subdural haematoma 24.82 9.77 17 148227 28037 64322451
Muscle rigidity 24.75 9.77 5 148239 17468 64333020
Swelling 24.71 9.77 242 148002 159976 64190512
Rash maculo-papular 24.56 9.77 44 148200 46982 64303506
American trypanosomiasis 24.55 9.77 13 148231 321 64350167
Anal stenosis 24.51 9.77 13 148231 322 64350166
Emotional distress 24.47 9.77 28 148216 36010 64314478
Steroid dependence 24.44 9.77 14 148230 405 64350083
Trichodysplasia spinulosa 24.34 9.77 17 148227 699 64349789
Salmonellosis 24.28 9.77 22 148222 1322 64349166
Leiomyosarcoma metastatic 24.24 9.77 6 148238 11 64350477
Memory impairment 24.08 9.77 108 148136 85574 64264914
Foot deformity 24.00 9.77 88 148156 16416 64334072
Withdrawal syndrome 23.95 9.77 12 148232 23480 64327008
Synovial cyst 23.91 9.77 54 148190 7653 64342835
Bronchitis 23.90 9.77 149 148095 108594 64241894
Pneumatosis intestinalis 23.84 9.77 43 148201 5186 64345302
Delusion 23.82 9.77 6 148238 18008 64332480
Acquired gene mutation 23.80 9.77 26 148218 1960 64348528
Dementia 23.72 9.77 9 148235 20757 64329731
Periumbilical abscess 23.64 9.77 8 148236 60 64350428
Myasthenic syndrome 23.55 9.77 16 148228 629 64349859
Proctocolectomy 23.48 9.77 9 148235 100 64350388
Enteritis 23.45 9.77 71 148173 12006 64338482
Rectal discharge 23.42 9.77 15 148229 533 64349955
Growth retardation 23.32 9.77 23 148221 1538 64348950
Mucous stools 23.32 9.77 33 148211 3240 64347248
Abscess rupture 23.20 9.77 12 148232 282 64350206
Enterostomy 23.20 9.77 11 148233 213 64350275
Altered state of consciousness 23.08 9.77 32 148212 37870 64312618
Antineutrophil cytoplasmic antibody increased 22.94 9.77 9 148235 107 64350381
Tonsillar hypertrophy 22.92 9.77 21 148223 1280 64349208
Hypersensitivity vasculitis 22.82 9.77 49 148195 6712 64343776
Cholesteatoma 22.79 9.77 9 148235 109 64350379
Drug tolerance 22.76 9.77 46 148198 6039 64344449
Proctitis 22.73 9.77 32 148212 3127 64347361
Graft versus host disease in lung 22.57 9.77 17 148227 787 64349701
Somatic delusion 22.57 9.77 16 148228 674 64349814
Dermatomyositis 22.57 9.77 30 148214 2776 64347712
Chronic myeloid leukaemia 22.55 9.77 33 148211 3341 64347147
Mydriasis 22.50 9.77 4 148240 15308 64335180
Eye infection toxoplasmal 22.49 9.77 14 148230 473 64350015
Neoplasm skin 22.43 9.77 20 148224 1177 64349311
Jejunal stenosis 22.37 9.77 8 148236 72 64350416
Drug level abnormal 22.32 9.77 10 148234 169 64350319
Rheumatoid lung 22.28 9.77 28 148216 2451 64348037
Asthma 22.23 9.77 128 148116 95097 64255391
Blood sodium decreased 22.17 9.77 21 148223 29461 64321027
Ejection fraction decreased 22.12 9.77 20 148224 28687 64321801
Glomerulosclerosis 21.91 9.77 18 148226 947 64349541
Pulmonary granuloma 21.91 9.77 24 148220 1815 64348673
Helicobacter infection 21.78 9.77 34 148210 38328 64312160
Pruritus 21.77 9.77 549 147695 311851 64038637
Anaplastic large-cell lymphoma 21.75 9.77 10 148234 180 64350308
Tenderness 21.69 9.77 96 148148 19506 64330982
Gastrointestinal mucosa hyperaemia 21.66 9.77 13 148231 411 64350077
Cytomegalovirus duodenitis 21.62 9.77 8 148236 80 64350408
Stiff person syndrome 21.56 9.77 11 148233 251 64350237
Arrhythmia 21.47 9.77 57 148187 52887 64297601
Jaw fracture 21.31 9.77 29 148215 2745 64347743
Therapy cessation 21.25 9.77 26 148218 32463 64318025
Pulmonary nocardiosis 21.20 9.77 16 148228 743 64349745
Intestinal mucosal hypertrophy 21.13 9.77 11 148233 262 64350226
Dysplasia 21.06 9.77 19 148225 1135 64349353
Device issue 21.02 9.77 13 148231 22635 64327853
Pulmonary embolism 20.94 9.77 225 148019 146131 64204357
Anorectal disorder 20.87 9.77 24 148220 1915 64348573
Hepatitis viral 20.80 9.77 17 148227 888 64349600
Chorioretinitis 20.75 9.77 15 148229 652 64349836
Head injury 20.73 9.77 27 148217 32815 64317673
Dyspnoea exertional 20.68 9.77 93 148151 73637 64276851
Gait disturbance 20.68 9.77 275 147969 171880 64178608
B-cell unclassifiable lymphoma high grade 20.63 9.77 5 148239 8 64350480
Wrist deformity 20.60 9.77 23 148221 1777 64348711
Tachycardia 20.59 9.77 232 148012 149347 64201141
Injection site mass 20.55 9.77 7 148237 17263 64333225
Rhabdomyolysis 20.51 9.77 125 148119 91601 64258887
Drug withdrawal syndrome 20.51 9.77 25 148219 31266 64319222
Microscopic polyangiitis 20.47 9.77 11 148233 280 64350208
Abnormal faeces 20.39 9.77 43 148201 5816 64344672
Blood cholesterol increased 20.37 9.77 190 148054 49876 64300612
Small intestine carcinoma 20.32 9.77 16 148228 792 64349696
Rectal stenosis 20.30 9.77 11 148233 285 64350203
Anogenital warts 20.25 9.77 16 148228 796 64349692
Cytomegalovirus syndrome 20.23 9.77 11 148233 287 64350201
Colectomy total 20.22 9.77 10 148234 213 64350275
Upper gastrointestinal haemorrhage 20.20 9.77 31 148213 35189 64315299
Enterovesical fistula 20.12 9.77 17 148227 930 64349558
Hypothyroidism 20.11 9.77 39 148205 40418 64310070
Liver function test increased 20.10 9.77 131 148113 30839 64319649
Wound 19.96 9.77 99 148145 76378 64274110
Nodule 19.93 9.77 88 148156 17859 64332629
Tonsil cancer 19.92 9.77 17 148227 943 64349545
Extrapyramidal disorder 19.92 9.77 10 148234 19542 64330946
Systemic lupus erythematosus 19.91 9.77 269 147975 77343 64273145
Pollakiuria 19.82 9.77 26 148218 31504 64318984
Hodgkin's disease 19.75 9.77 16 148228 825 64349663
Cytomegalovirus hepatitis 19.68 9.77 14 148230 593 64349895
Disseminated cryptococcosis 19.63 9.77 21 148223 1546 64348942
Urinary incontinence 19.63 9.77 33 148211 36118 64314370
Cervical dysplasia 19.62 9.77 23 148221 1873 64348615
Peritoneal tuberculosis 19.55 9.77 13 148231 493 64349995
Drug resistance 19.54 9.77 143 148101 34959 64315529
Chronic hepatitis 19.54 9.77 19 148225 1249 64349239
Gestational diabetes 19.43 9.77 41 148203 5549 64344939
Food intolerance 19.41 9.77 28 148216 2798 64347690
Chronic gastrointestinal bleeding 19.39 9.77 12 148232 401 64350087
Porokeratosis 19.37 9.77 10 148234 234 64350254
Granuloma skin 19.34 9.77 43 148201 6031 64344457
Autoimmune neutropenia 19.26 9.77 12 148232 406 64350082
Premature separation of placenta 19.26 9.77 18 148226 1126 64349362
Intestinal fibrosis 19.22 9.77 8 148236 112 64350376
Graft loss 19.21 9.77 17 148227 990 64349498
Peripheral T-cell lymphoma unspecified stage IV 19.16 9.77 6 148238 34 64350454
Pancreatitis acute 19.16 9.77 166 148078 42689 64307799
Carcinoid tumour pulmonary 19.08 9.77 11 148233 322 64350166
Trichostasis spinulosa 19.01 9.77 5 148239 13 64350475
Hyperthyroidism 18.97 9.77 9 148235 18170 64332318
Palatal ulcer 18.96 9.77 8 148236 116 64350372
Electrolyte imbalance 18.96 9.77 18 148226 25225 64325263
Hypophagia 18.96 9.77 39 148205 39548 64310940
Epstein-Barr viraemia 18.93 9.77 22 148222 1775 64348713
Necrotising herpetic retinopathy 18.90 9.77 8 148236 117 64350371
Joint effusion 18.89 9.77 71 148173 13402 64337086
Splenic embolism 18.76 9.77 9 148235 179 64350309
Myoclonus 18.76 9.77 18 148226 25100 64325388
Polyhydramnios 18.75 9.77 20 148224 1467 64349021
Dyspepsia 18.72 9.77 108 148136 80204 64270284
Creatinine renal clearance decreased 18.69 9.77 5 148239 14416 64336072
Urticaria 18.69 9.77 457 147787 146860 64203628
Femur fracture 18.68 9.77 31 148213 34104 64316384
Brain stem syndrome 18.66 9.77 15 148229 765 64349723
Leiomyosarcoma 18.56 9.77 10 148234 256 64350232
Angioedema 18.55 9.77 76 148168 61745 64288743
Intestinal ulcer 18.52 9.77 21 148223 1650 64348838
Paracoccidioides infection 18.49 9.77 7 148237 75 64350413
Cryptococcosis 18.49 9.77 27 148217 2728 64347760
Hip fracture 18.46 9.77 21 148223 27078 64323410
Necrotising retinitis 18.42 9.77 17 148227 1046 64349442
Henoch-Schonlein purpura 18.38 9.77 24 148220 2182 64348306
Paraesthesia 18.37 9.77 209 148035 134313 64216175
Bacillary angiomatosis 18.36 9.77 9 148235 188 64350300
Pyrexia 18.34 9.77 1506 146738 557138 63793350
Vasculitis necrotising 18.30 9.77 17 148227 1055 64349433
Eye ulcer 18.21 9.77 10 148234 266 64350222
Transient hypogammaglobulinaemia of infancy 18.21 9.77 6 148238 41 64350447
Product administration error 18.21 9.77 22 148222 27621 64322867
Hospitalisation 18.15 9.77 100 148144 75107 64275381
Oesophageal squamous cell carcinoma 18.00 9.77 12 148232 457 64350031
Oral pain 17.98 9.77 22 148222 27471 64323017
Lymph node tuberculosis 17.96 9.77 16 148228 940 64349548
Mouth ulceration 17.96 9.77 132 148112 32312 64318176
Blood glucose decreased 17.94 9.77 16 148228 23107 64327381
Blood parathyroid hormone decreased 17.92 9.77 47 148197 7319 64343169
HELLP syndrome 17.92 9.77 14 148230 685 64349803
Lymphocytic infiltration 17.91 9.77 19 148225 1385 64349103
Dry skin 17.91 9.77 59 148185 51102 64299386
Disease progression 17.87 9.77 224 148020 141456 64209032
Tractional retinal detachment 17.86 9.77 7 148237 83 64350405
Weber tuning fork test abnormal 17.78 9.77 7 148237 84 64350404
Irritable bowel syndrome 17.74 9.77 37 148207 37332 64313156
Cystitis escherichia 17.72 9.77 12 148232 469 64350019
Faecal calprotectin abnormal 17.71 9.77 8 148236 138 64350350
Flank pain 17.69 9.77 79 148165 16110 64334378
Gastrointestinal obstruction 17.68 9.77 19 148225 1406 64349082
Antisynthetase syndrome 17.65 9.77 8 148236 139 64350349
Burkitt's lymphoma stage III 17.59 9.77 5 148239 19 64350469
Hepatitis 17.56 9.77 171 148073 45411 64305077
Pseudoxanthoma elasticum-like syndrome 17.55 9.77 4 148240 4 64350484
Depressed mood 17.52 9.77 43 148201 40969 64309519
Infective pulmonary exacerbation of cystic fibrosis 17.51 9.77 3 148241 11793 64338695
Gastrointestinal stoma output abnormal 17.50 9.77 6 148238 47 64350441
Neuromyelitis optica spectrum disorder 17.42 9.77 15 148229 842 64349646
Amnesia 17.36 9.77 55 148189 48214 64302274
Dermatitis psoriasiform 17.35 9.77 23 148221 2123 64348365
Retinal scar 17.32 9.77 11 148233 385 64350103
Ileal ulcer 17.24 9.77 16 148228 992 64349496
Viral test positive 17.22 9.77 11 148233 389 64350099
Laparotomy 17.22 9.77 10 148234 297 64350191
Gastrooesophageal reflux disease 17.21 9.77 116 148128 83027 64267461
Appendicectomy 17.20 9.77 23 148221 2140 64348348
Anastomotic complication 17.20 9.77 11 148233 390 64350098
Acne conglobata 17.19 9.77 5 148239 21 64350467
Lung neoplasm 17.19 9.77 42 148202 6263 64344225
Epistaxis 17.16 9.77 319 147925 97812 64252676
Muscle spasms 17.15 9.77 435 147809 140588 64209900
Focal segmental glomerulosclerosis 17.13 9.77 27 148217 2917 64347571
Conjunctivitis 17.01 9.77 92 148152 20262 64330226
Optic neuritis 16.98 9.77 49 148195 8067 64342421
Nightmare 16.93 9.77 14 148230 20979 64329509
Infertility 16.83 9.77 12 148232 510 64349978
Respiratory gas exchange disorder 16.81 9.77 14 148230 751 64349737
Aspergillosis oral 16.78 9.77 6 148238 54 64350434
Laryngeal disorder 16.76 9.77 15 148229 887 64349601
Gastrointestinal stoma complication 16.69 9.77 23 148221 2203 64348285
Cytokine release syndrome 16.66 9.77 14 148230 20815 64329673
Hodgkin's disease nodular sclerosis 16.66 9.77 5 148239 24 64350464
Headache 16.65 9.77 1022 147222 528445 63822043
Therapy interrupted 16.61 9.77 13 148231 20023 64330465
Encephalopathy 16.61 9.77 74 148170 58745 64291743
Haematemesis 16.59 9.77 54 148190 46945 64303543
Testicular cancer metastatic 16.58 9.77 6 148238 56 64350432
Malignant polyp 16.54 9.77 8 148236 162 64350326
Fistula of small intestine 16.53 9.77 13 148231 642 64349846
Haemophilus infection 16.48 9.77 21 148223 1864 64348624
Hypergammaglobulinaemia 16.46 9.77 13 148231 646 64349842
Pneumonia legionella 16.46 9.77 24 148220 2422 64348066
Hepatic enzyme increased 16.45 9.77 403 147841 129540 64220948
Pseudomonas infection 16.44 9.77 83 148161 17800 64332688
Ileectomy 16.41 9.77 8 148236 165 64350323
Febrile bone marrow aplasia 16.41 9.77 3 148241 11252 64339236
Chest discomfort 16.40 9.77 179 148065 115927 64234561
Intestinal dilatation 16.39 9.77 23 148221 2241 64348247
Marrow hyperplasia 16.38 9.77 18 148226 1366 64349122
Mycetoma mycotic 16.38 9.77 7 148237 105 64350383
Ventricular extrasystoles 16.36 9.77 10 148234 17519 64332969
Cardiogenic shock 16.34 9.77 31 148213 32396 64318092
Mucocutaneous leishmaniasis 16.31 9.77 11 148233 427 64350061
Muscle spasticity 16.28 9.77 9 148235 16660 64333828
Renal impairment 16.28 9.77 416 147828 134601 64215887
Ischaemic stroke 16.23 9.77 26 148218 29009 64321479
Narcotic bowel syndrome 16.20 9.77 9 148235 245 64350243
Stevens-Johnson syndrome 16.18 9.77 34 148210 34215 64316273
Neutrophilic dermatosis 16.17 9.77 12 148232 543 64349945
Discomfort 16.17 9.77 114 148130 80764 64269724
Systemic candida 16.16 9.77 37 148207 5292 64345196
Herpes zoster meningoencephalitis 15.94 9.77 13 148231 677 64349811
Skin cancer 15.88 9.77 62 148182 11912 64338576
Sebaceous carcinoma 15.80 9.77 7 148237 115 64350373
Corynebacterium infection 15.79 9.77 15 148229 958 64349530
Ventricular fibrillation 15.71 9.77 19 148225 23841 64326647
Skin papilloma 15.64 9.77 36 148208 5167 64345321
Fear 15.60 9.77 14 148230 20157 64330331
Exercise tolerance increased 15.59 9.77 5 148239 31 64350457
Stress at work 15.58 9.77 15 148229 974 64349514
Anal skin tags 15.55 9.77 10 148234 358 64350130
Troponin increased 15.50 9.77 8 148236 15391 64335097
Cardiac valve vegetation 15.48 9.77 14 148230 839 64349649
Hepatitis B 15.48 9.77 46 148198 7699 64342789
DNA antibody 15.46 9.77 5 148239 32 64350456
Eosinophilic bronchitis 15.37 9.77 10 148234 365 64350123
Hallucination, auditory 15.34 9.77 10 148234 16929 64333559
Bowel movement irregularity 15.34 9.77 34 148210 4759 64345729
Blood bilirubin increased 15.31 9.77 74 148170 57479 64293009
Anaphylactic shock 15.28 9.77 29 148215 30299 64320189
Blood potassium decreased 15.27 9.77 45 148199 40354 64310134
Laryngeal mass 15.24 9.77 6 148238 72 64350416
Herpes simplex test positive 15.23 9.77 10 148234 371 64350117
Sleep disorder due to general medical condition, insomnia type 15.19 9.77 23 148221 26247 64324241
Herpes simplex 15.17 9.77 56 148188 10480 64340008
Epstein-Barr virus antibody positive 15.15 9.77 12 148232 599 64349889
Acinetobacter infection 15.15 9.77 23 148221 2406 64348082
Human ehrlichiosis 15.13 9.77 10 148234 375 64350113
Injection site pruritus 15.13 9.77 41 148203 37785 64312703
Mycobacterium kansasii infection 15.12 9.77 9 148235 280 64350208
Mucormycosis 15.05 9.77 44 148200 7297 64343191
Pyometra 15.02 9.77 6 148238 75 64350413
Heart rate decreased 15.01 9.77 193 148051 54874 64295614
Anaemia macrocytic 14.99 9.77 32 148212 4366 64346122
Folliculitis 14.94 9.77 29 148215 30048 64320440
Hypoxia 14.94 9.77 130 148114 88019 64262469
Retinal injury 14.89 9.77 9 148235 288 64350200
Ileal perforation 14.89 9.77 14 148230 882 64349606
Product storage error 14.84 9.77 6 148238 13312 64337176
Tinea capitis 14.79 9.77 4 148240 12 64350476
Placental necrosis 14.79 9.77 4 148240 12 64350476
Torsade de pointes 14.74 9.77 11 148233 17352 64333136
Obstructive airways disorder 14.70 9.77 19 148225 23166 64327322
Haematocrit decreased 14.70 9.77 70 148174 54585 64295903
Anger 14.66 9.77 9 148235 15732 64334756
Drug specific antibody absent 14.60 9.77 7 148237 139 64350349
Hallucination, visual 14.57 9.77 26 148218 27808 64322680
Listeria encephalitis 14.57 9.77 9 148235 300 64350188
Mitochondrial neurogastrointestinal encephalopathy 14.55 9.77 4 148240 13 64350475
Glomerulonephritis 14.54 9.77 25 148219 2903 64347585
Pneumonia cryptococcal 14.47 9.77 16 148228 1223 64349265
Hidradenitis 14.45 9.77 22 148222 2307 64348181
Oxygen saturation decreased 14.44 9.77 167 148077 107009 64243479
Meningitis aseptic 14.39 9.77 37 148207 5693 64344795
Gastrointestinal oedema 14.37 9.77 22 148222 2318 64348170
Complications of transplanted heart 14.35 9.77 9 148235 308 64350180
Proctectomy 14.35 9.77 6 148238 85 64350403
Atrial flutter 14.34 9.77 14 148230 19366 64331122
Joint tuberculosis 14.33 9.77 7 148237 145 64350343
Respiratory tract infection fungal 14.33 9.77 15 148229 1077 64349411
Hand deformity 14.32 9.77 85 148159 62686 64287802
Pharyngeal oedema 14.30 9.77 9 148235 15522 64334966
Chest pain 14.27 9.77 423 147821 235557 64114931
Night sweats 14.27 9.77 136 148108 35910 64314578
Salivary hypersecretion 14.26 9.77 5 148239 12108 64338380
Skin necrosis 14.24 9.77 68 148176 14261 64336227
Cough 14.23 9.77 559 147685 301589 64048899
Toxic skin eruption 14.19 9.77 14 148230 19270 64331218
Angina unstable 14.19 9.77 9 148235 15458 64335030
Lethargy 14.18 9.77 103 148141 72491 64277997
Primary effusion lymphoma 14.18 9.77 5 148239 43 64350445
Tuberous sclerosis complex 14.16 9.77 6 148238 88 64350400
Aspartate aminotransferase increased 14.14 9.77 192 148052 119596 64230892
Tricuspid valve incompetence 14.14 9.77 11 148233 16992 64333496
Diffuse large B-cell lymphoma stage III 14.10 9.77 6 148238 89 64350399
Intestinal operation 14.09 9.77 10 148234 422 64350066
Sideroblastic anaemia 14.04 9.77 8 148236 229 64350259
Oral lichen planus 14.01 9.77 12 148232 669 64349819
Palpitations 14.01 9.77 163 148081 104325 64246163
Perirectal abscess 14.00 9.77 19 148225 1794 64348694
Necrosis 13.99 9.77 46 148198 8125 64342363
Rectal cancer 13.99 9.77 24 148220 2782 64347706
Fungal peritonitis 13.94 9.77 14 148230 957 64349531
Whipple's disease 13.91 9.77 4 148240 16 64350472
Ureteral neoplasm 13.91 9.77 4 148240 16 64350472
Pulmonary paracoccidioidomycosis 13.91 9.77 4 148240 16 64350472
Tenosynovitis 13.89 9.77 59 148185 11774 64338714
Failed induction of labour 13.89 9.77 8 148236 234 64350254
Gastrointestinal scarring 13.89 9.77 8 148236 234 64350254
Blood potassium increased 13.84 9.77 24 148220 25956 64324532
Adverse reaction 13.82 9.77 44 148200 7643 64342845
Dysphagia 13.79 9.77 168 148076 106644 64243844
Anal squamous cell carcinoma 13.72 9.77 10 148234 440 64350048
Retinal vasculitis 13.72 9.77 15 148229 1132 64349356
Pulmonary congestion 13.71 9.77 21 148223 23859 64326629
Cervix carcinoma 13.71 9.77 19 148225 1829 64348659
Parkinsonism 13.69 9.77 8 148236 14365 64336123
Rhinitis 13.68 9.77 55 148189 10710 64339778
Toxic epidermal necrolysis 13.61 9.77 42 148202 37124 64313364
Polyuria 13.60 9.77 6 148238 12637 64337851
Drug withdrawal syndrome neonatal 13.58 9.77 8 148236 244 64350244
Skin exfoliation 13.58 9.77 55 148189 44830 64305658
Throat cancer 13.54 9.77 14 148230 991 64349497
Foetal exposure during pregnancy 13.48 9.77 31 148213 4445 64346043
Oesophagitis 13.43 9.77 18 148226 21612 64328876
Acne 13.41 9.77 95 148149 22986 64327502
Transplant failure 13.39 9.77 28 148216 3766 64346722
Butterfly rash 13.35 9.77 15 148229 1167 64349321
Anovulatory cycle 13.31 9.77 6 148238 103 64350385
Drug specific antibody 13.30 9.77 20 148224 2075 64348413
Anastomotic stenosis 13.26 9.77 10 148234 464 64350024
Oesophagopleural fistula 13.26 9.77 5 148239 53 64350435
Thinking abnormal 13.21 9.77 5 148239 11551 64338937
Peritoneal candidiasis 13.19 9.77 4 148240 20 64350468
Skin hyperpigmentation 13.18 9.77 39 148205 6512 64343976
Enterostomy closure 13.16 9.77 3 148241 3 64350485
Antineutrophil cytoplasmic antibody decreased 13.16 9.77 3 148241 3 64350485
Precursor T-lymphoblastic lymphoma/leukaemia stage I 13.16 9.77 3 148241 3 64350485
Faecaluria 13.16 9.77 3 148241 3 64350485
Swollen tongue 13.16 9.77 39 148205 34915 64315573
Mediastinal effusion 13.09 9.77 5 148239 55 64350433
Small intestinal resection 13.09 9.77 12 148232 732 64349756
Hepatic fibrosis 13.08 9.77 35 148209 5517 64344971
Skin mass 13.07 9.77 41 148203 7065 64343423
Trichosporon infection 13.06 9.77 13 148231 879 64349609
Immunodeficiency common variable 13.05 9.77 8 148236 263 64350225
Metastatic malignant melanoma 13.02 9.77 22 148222 2519 64347969
Varicella zoster pneumonia 13.00 9.77 6 148238 109 64350379
Mycobacterium chelonae infection 13.00 9.77 20 148224 2117 64348371
Ear infection 12.83 9.77 95 148149 23309 64327179
Acute respiratory failure 12.82 9.77 65 148179 49869 64300619
Renal injury 12.81 9.77 10 148234 15419 64335069
Rectal tenesmus 12.78 9.77 14 148230 1059 64349429
Small intestinal perforation 12.77 9.77 22 148222 2558 64347930
Aspiration 12.73 9.77 12 148232 16873 64333615
Femoral artery aneurysm 12.72 9.77 7 148237 187 64350301
Peripheral artery aneurysm 12.68 9.77 9 148235 380 64350108
Adenocarcinoma of colon 12.65 9.77 32 148212 4876 64345612
Gastroenterostomy 12.63 9.77 5 148239 61 64350427
Foetal malpresentation 12.63 9.77 5 148239 61 64350427
Deep vein thrombosis 12.63 9.77 168 148076 105014 64245474
Nervousness 12.62 9.77 31 148213 29525 64320963
Skin striae 12.61 9.77 16 148228 1414 64349074
Abdominal pain upper 12.60 9.77 306 147938 174724 64175764
Laser therapy 12.58 9.77 4 148240 24 64350464
Hot flush 12.56 9.77 59 148185 46176 64304312
Impetigo 12.56 9.77 18 148226 1788 64348700
Premature baby 12.55 9.77 25 148219 3247 64347241
DNA antibody positive 12.52 9.77 8 148236 283 64350205
Myelitis transverse 12.52 9.77 17 148227 1606 64348882
Ocular toxicity 12.51 9.77 11 148233 635 64349853
Cardiotoxicity 12.51 9.77 4 148240 10270 64340218
Blood creatine phosphokinase increased 12.47 9.77 81 148163 58477 64292011
Hyperlipidaemia 12.45 9.77 21 148223 22955 64327533
Burkitt's lymphoma 12.43 9.77 6 148238 121 64350367
Needle issue 12.43 9.77 3 148241 9269 64341219
Injection site haemorrhage 12.42 9.77 23 148221 24255 64326233
Gastrointestinal ulcer 12.41 9.77 24 148220 3051 64347437
Anal ulcer 12.40 9.77 14 148230 1095 64349393
Herpes virus infection 12.40 9.77 37 148207 6207 64344281
Graft complication 12.37 9.77 11 148233 645 64349843
Pseudopolyposis 12.34 9.77 5 148239 65 64350423
Renal cell carcinoma stage III 12.31 9.77 4 148240 26 64350462
Gastrointestinal dilation procedure 12.30 9.77 3 148241 5 64350483
Pulmonary function test increased 12.30 9.77 3 148241 5 64350483
Diaphragmatic injury 12.30 9.77 6 148238 124 64350364
Kidney fibrosis 12.27 9.77 24 148220 3077 64347411
Mycoplasma test positive 12.23 9.77 7 148237 202 64350286
Cyanosis 12.23 9.77 20 148224 22135 64328353
Adjustment disorder with depressed mood 12.23 9.77 21 148223 2436 64348052
Blood urea increased 12.20 9.77 56 148188 44097 64306391
Sleep apnoea syndrome 12.19 9.77 32 148212 29800 64320688
Haemolysis 12.16 9.77 54 148190 10985 64339503
Rash pustular 12.16 9.77 50 148194 9835 64340653
Cutaneous lupus erythematosus 12.16 9.77 22 148222 2660 64347828
Electrocardiogram abnormal 12.15 9.77 8 148236 13473 64337015
Pneumonitis 12.13 9.77 67 148177 50298 64300190
Dysphonia 12.13 9.77 60 148184 46322 64304166
Hirsutism 12.12 9.77 13 148231 960 64349528
Atypical mycobacterial infection 12.12 9.77 15 148229 1293 64349195
Iron deficiency anaemia 12.08 9.77 89 148155 21800 64328688
Deafness transitory 12.06 9.77 12 148232 811 64349677
Acute coronary syndrome 12.06 9.77 16 148228 19294 64331194
Herpes simplex colitis 12.06 9.77 4 148240 28 64350460
Transaminases increased 12.03 9.77 156 148088 44438 64306050
Psychotic disorder 12.02 9.77 40 148204 34538 64315950
Diabetes mellitus inadequate control 12.01 9.77 19 148225 21302 64329186
Infective tenosynovitis 11.99 9.77 8 148236 305 64350183
Cerebral infarction 11.98 9.77 51 148193 40993 64309495
Anaplastic large cell lymphoma T- and null-cell types stage III 11.95 9.77 3 148241 6 64350482
Actinic cheilitis 11.95 9.77 3 148241 6 64350482
Cryoglobulins present 11.95 9.77 3 148241 6 64350482
Cholangitis chronic 11.94 9.77 4 148240 29 64350459
Peripheral swelling 11.89 9.77 378 147866 208775 64141713
Epstein-Barr virus infection reactivation 11.83 9.77 14 148230 1152 64349336
Subarachnoid haemorrhage 11.80 9.77 15 148229 18423 64332065
Vascular graft complication 11.80 9.77 6 148238 136 64350352
Gingival hypertrophy 11.78 9.77 22 148222 2725 64347763
Faeces discoloured 11.77 9.77 26 148218 25703 64324785
Thrombotic microangiopathy 11.77 9.77 72 148172 16583 64333905
Renal tubular atrophy 11.77 9.77 16 148228 1513 64348975
Injection site induration 11.76 9.77 3 148241 8929 64341559
Enterocolonic fistula 11.76 9.77 6 148238 137 64350351
Arteriosclerosis coronary artery 11.75 9.77 11 148233 15518 64334970
Pyoderma 11.74 9.77 8 148236 316 64350172
Ileostomy closure 11.72 9.77 6 148238 138 64350350
Vitamin B1 decreased 11.72 9.77 8 148236 317 64350171
Eosinophilic myocarditis 11.71 9.77 12 148232 840 64349648
Threatened labour 11.71 9.77 10 148234 555 64349933
Cytopenia 11.65 9.77 68 148176 15403 64335085
Spindle cell sarcoma 11.64 9.77 7 148237 222 64350266
Paradoxical psoriasis 11.60 9.77 6 148238 141 64350347
Metastases to central nervous system 11.57 9.77 9 148235 13903 64336585
Second primary malignancy 11.57 9.77 7 148237 12330 64338158
Abdominal pain lower 11.55 9.77 102 148142 26367 64324121
Gastrointestinal motility disorder 11.55 9.77 32 148212 5147 64345341
Small intestine adenocarcinoma 11.52 9.77 6 148238 143 64350345
Total bile acids increased 11.52 9.77 5 148239 78 64350410
Product dispensing error 11.45 9.77 6 148238 11444 64339044
Diarrhoea 11.44 9.77 1471 146773 721233 63629255
Ophthalmic herpes simplex 11.43 9.77 10 148234 574 64349914
Cerebral fungal infection 11.41 9.77 8 148236 331 64350157
Cleft lip and palate 11.41 9.77 5 148239 80 64350408
Joint dislocation reduction 11.38 9.77 4 148240 34 64350454
Lacrimal haemorrhage 11.38 9.77 4 148240 34 64350454
Overgrowth bacterial 11.37 9.77 6 148238 147 64350341
Molluscum contagiosum 11.37 9.77 9 148235 449 64350039
Pulmonary thrombosis 11.30 9.77 5 148239 10513 64339975
Fasting 11.28 9.77 4 148240 35 64350453
Tumour lysis syndrome 11.26 9.77 17 148227 19423 64331065
Presyncope 11.25 9.77 42 148202 35047 64315441
Germ cell cancer 11.23 9.77 6 148238 151 64350337
Psychomotor hyperactivity 11.21 9.77 10 148234 14441 64336047
Stoma complication 11.16 9.77 9 148235 461 64350027
Gastric fistula 11.16 9.77 6 148238 153 64350335
Alanine aminotransferase increased 11.15 9.77 239 148005 138792 64211696
Renal failure 11.15 9.77 325 147919 181363 64169125
Parvovirus B19 infection 11.14 9.77 14 148230 1225 64349263
COVID-19 11.13 9.77 211 148033 64929 64285559
Idiopathic pulmonary fibrosis 11.10 9.77 26 148218 3774 64346714
Tonsillitis 11.10 9.77 34 148210 5786 64344702
Hepatobiliary cancer 11.10 9.77 3 148241 9 64350479
Neuropsychiatric lupus 11.09 9.77 6 148238 155 64350333
Klebsiella infection 11.08 9.77 60 148184 13221 64337267
Rheumatoid factor positive 11.07 9.77 126 148118 34812 64315676
Iron deficiency 11.06 9.77 39 148205 7138 64343350
Complication associated with device 11.04 9.77 11 148233 15069 64335419
Pharyngitis bacterial 11.02 9.77 7 148237 245 64350243
Peritoneal abscess 11.02 9.77 7 148237 245 64350243
Toxoplasmosis 11.02 9.77 20 148224 2424 64348064
Abnormal dreams 11.00 9.77 5 148239 10351 64340137
Gastrointestinal disorder 10.98 9.77 277 147967 89432 64261056
Relapsing fever 10.98 9.77 8 148236 352 64350136
Renal transplant 10.91 9.77 19 148225 2229 64348259
Panniculitis lobular 10.90 9.77 4 148240 39 64350449
Oropharyngeal squamous cell carcinoma 10.90 9.77 7 148237 250 64350238
Cholestasis 10.89 9.77 154 148090 44718 64305770
Coordination abnormal 10.86 9.77 11 148233 14953 64335535
Amniotic cavity infection 10.82 9.77 11 148233 763 64349725
Cryptococcal cutaneous infection 10.81 9.77 6 148238 163 64350325
Cardiomegaly 10.78 9.77 24 148220 23660 64326828
Haematuria 10.78 9.77 88 148156 60383 64290105
Pneumonia herpes viral 10.75 9.77 6 148238 165 64350323
Generalised tonic-clonic seizure 10.74 9.77 51 148193 39806 64310682
Injection site reaction 10.74 9.77 63 148181 46601 64303887
Gastroenteritis clostridial 10.73 9.77 11 148233 771 64349717
Vascular shunt 10.72 9.77 4 148240 41 64350447
Superinfection viral 10.72 9.77 4 148240 41 64350447
Burkholderia pseudomallei infection 10.72 9.77 4 148240 41 64350447
Renal atrophy 10.72 9.77 16 148228 1648 64348840
Erectile dysfunction 10.72 9.77 8 148236 12619 64337869
Mania 10.69 9.77 13 148231 16273 64334215
Spondyloarthropathy 10.68 9.77 11 148233 775 64349713
Colonic abscess 10.67 9.77 13 148231 1102 64349386
Fibroadenoma of breast 10.65 9.77 7 148237 260 64350228
Cushing's syndrome 10.62 9.77 12 148232 939 64349549
Tuberculosis gastrointestinal 10.61 9.77 9 148235 495 64349993
Lupus endocarditis 10.55 9.77 6 148238 171 64350317
Otorrhoea 10.53 9.77 15 148229 1482 64349006
Upper respiratory tract irritation 10.49 9.77 5 148239 98 64350390
Enterobacter infection 10.48 9.77 25 148219 3671 64346817
Infected fistula 10.47 9.77 7 148237 268 64350220
Device leakage 10.46 9.77 3 148241 8263 64342225
Telangiectasia 10.46 9.77 13 148231 1125 64349363
Dystonia 10.44 9.77 17 148227 18848 64331640
Paraproteinaemia 10.44 9.77 8 148236 380 64350108
Laryngeal stenosis 10.44 9.77 11 148233 796 64349692
Diffuse large B-cell lymphoma stage I 10.43 9.77 3 148241 12 64350476
Hepatic angiosarcoma 10.43 9.77 3 148241 12 64350476
Uveal melanoma 10.43 9.77 3 148241 12 64350476
Myelitis 10.43 9.77 18 148226 2096 64348392
Dengue fever 10.43 9.77 11 148233 797 64349691
Lower gastrointestinal haemorrhage 10.40 9.77 10 148234 13929 64336559
Intestinal polyp 10.39 9.77 16 148228 1695 64348793
Sudden death 10.31 9.77 19 148225 20077 64330411
Cutaneous nocardiosis 10.31 9.77 6 148238 179 64350309
Incorrect route of product administration 10.29 9.77 24 148220 23274 64327214
Oedema 10.26 9.77 149 148095 91786 64258702
Central nervous system necrosis 10.26 9.77 7 148237 277 64350211
Hepatitis chronic active 10.25 9.77 6 148238 181 64350307
Infusion site paraesthesia 10.24 9.77 3 148241 13 64350475
Meningeal neoplasm 10.24 9.77 3 148241 13 64350475
Spleen palpable 10.24 9.77 3 148241 13 64350475
Superficial spreading melanoma stage unspecified 10.24 9.77 7 148237 278 64350210
Feeling jittery 10.23 9.77 50 148194 10585 64339903
Mood altered 10.23 9.77 13 148231 15966 64334522
Gastric ulcer haemorrhage 10.22 9.77 3 148241 8140 64342348
Post transplant distal limb syndrome 10.22 9.77 9 148235 521 64349967
Tinnitus 10.21 9.77 42 148202 34091 64316397
Peritonitis 10.20 9.77 95 148149 24928 64325560
Infective aortitis 10.16 9.77 4 148240 48 64350440
Akathisia 10.15 9.77 7 148237 11503 64338985
Testicular abscess 10.09 9.77 4 148240 49 64350439
Tuberculosis of eye 10.09 9.77 4 148240 49 64350439
Hypoaesthesia 10.07 9.77 243 148001 138865 64211623
Burkholderia cepacia complex infection 10.06 9.77 7 148237 286 64350202
Pulmonary venous thrombosis 10.05 9.77 5 148239 108 64350380
Blood pressure abnormal 10.04 9.77 11 148233 14424 64336064
Aspiration bone marrow 10.02 9.77 4 148240 50 64350438
Vertigo 10.01 9.77 87 148157 58924 64291564
Renal phospholipidosis 10.01 9.77 5 148239 109 64350379
Blood glucose abnormal 9.95 9.77 4 148240 8909 64341579
Photophobia 9.94 9.77 71 148173 17222 64333266
Burning sensation 9.92 9.77 70 148174 49594 64300894
Bursitis infective 9.91 9.77 13 148231 1187 64349301
Liver sarcoidosis 9.89 9.77 3 148241 15 64350473
Conjunctivochalasis 9.89 9.77 3 148241 15 64350473
Metastases to nasal sinuses 9.89 9.77 3 148241 15 64350473
Therapeutic response unexpected 9.89 9.77 70 148174 16931 64333557
Muir-Torre syndrome 9.88 9.77 4 148240 52 64350436
Rotator cuff syndrome 9.86 9.77 8 148236 12099 64338389
Pseudolymphoma 9.86 9.77 12 148232 1017 64349471
Conjunctivitis allergic 9.85 9.77 12 148232 1018 64349470
Viral sepsis 9.84 9.77 5 148239 113 64350375
Hepatitis E 9.84 9.77 19 148225 2412 64348076
Gastrointestinal stoma output decreased 9.81 9.77 4 148240 53 64350435
Koebner phenomenon 9.81 9.77 4 148240 53 64350435
Isosporiasis 9.80 9.77 5 148239 114 64350374
Allergy to chemicals 9.78 9.77 12 148232 1025 64349463
Acute pulmonary oedema 9.78 9.77 9 148235 12800 64337688

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Hydrops foetalis 56.23 32.05 17 194 80 84387

Pharmacologic Action:

SourceCodeDescription
ATC L04AX01 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
IMMUNOSUPPRESSANTS
IMMUNOSUPPRESSANTS
Other immunosuppressants
FDA CS M0015066 Nucleosides
FDA CS M0018169 Purines
FDA MoA N0000000233 Nucleic Acid Synthesis Inhibitors
MeSH PA D000963 Antimetabolites
MeSH PA D000964 Antimetabolites, Antineoplastic
MeSH PA D000970 Antineoplastic Agents
MeSH PA D018501 Antirheumatic Agents
MeSH PA D007155 Immunologic Factors
MeSH PA D007166 Immunosuppressive Agents
MeSH PA D009676 Noxae
FDA EPC N0000175712 Purine Antimetabolite

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Refractory idiopathic thrombocytopenic purpura indication 13172003
Relapsing multiple sclerosis indication 24700007 DOID:2377
Crohn's disease indication 34000006
Pemphigus vulgaris indication 49420001 DOID:0060851
Systemic lupus erythematosus indication 55464009 DOID:9074
Ulcerative colitis indication 64766004 DOID:8577
Rheumatoid arthritis indication 69896004 DOID:7148
Bullous pemphigoid indication 77090002 DOID:8506
Myasthenia gravis indication 91637004 DOID:437
Polyarteritis nodosa indication 155441006 DOID:9810
Behcet's disease indication 310701003 DOID:13241
Dermatomyositis indication 396230008 DOID:10223
Autoimmune hepatitis indication 408335007
Refractory autoimmune haemolytic anaemia indication 413603009 DOID:718
Prevention of Kidney Transplant Rejection indication
Polymyositis off-label use 31384009
Prevention of Lung Transplant Rejection off-label use
Prevention of Cardiac Transplant Rejection off-label use
Prevention of Liver Transplant Rejection off-label use
Mycosis contraindication 3218000 DOID:1564
Viral disease contraindication 34014006 DOID:934
Hepatic vein thrombosis contraindication 38739001 DOID:11512
Bacterial infectious disease contraindication 87628006
Malignant lymphoma contraindication 118600007 DOID:0060058
Liver function tests abnormal contraindication 166603001
Acute pancreatitis contraindication 197456007 DOID:2913
Impaired renal function disorder contraindication 197663003
Anemia contraindication 271737000 DOID:2355
Pregnancy, function contraindication 289908002
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Bone marrow depression contraindication 307762000
Hepatosplenic T-cell lymphoma contraindication 445406001
Thiopurine S-Methyltransferase Deficiency contraindication
Severe Leukopenia contraindication
Protozoal Infection contraindication




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.28 acidic
pKa2 3.24 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
ATP-binding cassette sub-family G member 2 Transporter WOMBAT-PK
Multidrug resistance-associated protein 5 Transporter WOMBAT-PK
Multidrug resistance-associated protein 4 Transporter WOMBAT-PK
Ras-related C3 botulinum toxin substrate 1 Enzyme WOMBAT-PK
Thiopurine S-methyltransferase Enzyme WOMBAT-PK

External reference:

IDSource
4018766 VUID
N0000147069 NUI
D00238 KEGG_DRUG
55774-33-9 SECONDARY_CAS_RN
1256 RXNORM
C0004482 UMLSCUI
CHEMBL1542 ChEMBL_ID
DB00993 DRUGBANK_ID
CHEMBL1200400 ChEMBL_ID
D001379 MESH_DESCRIPTOR_UI
2265 PUBCHEM_CID
7120 IUPHAR_LIGAND_ID
1291 INN_ID
MRK240IY2L UNII
3341 MMSL
4234 MMSL
4235 MMSL
6041 MMSL
d00024 MMSL
003419 NDDF
004123 NDDF
4018766 VANDF
111165009 SNOMEDCT_US
372574004 SNOMEDCT_US
67221004 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Azathioprine Sodium HUMAN PRESCRIPTION DRUG LABEL 1 0143-9566 INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION 100 mg INTRAVENOUS ANDA 22 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 0378-1005 TABLET 50 mg ORAL ANDA 23 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 21695-484 TABLET 50 mg ORAL ANDA 20 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 33261-758 TABLET 50 mg ORAL ANDA 20 sections
AZATHIOPRINE HUMAN PRESCRIPTION DRUG LABEL 1 42291-071 TABLET 50 mg ORAL ANDA 19 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 43353-745 TABLET 50 mg ORAL ANDA 23 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 51407-182 TABLET 50 mg ORAL ANDA 14 sections
IMURAN HUMAN PRESCRIPTION DRUG LABEL 1 54766-590 TABLET 50 mg ORAL NDA 23 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 54868-5310 TABLET 50 mg ORAL ANDA 20 sections
AZATHIOPRINE HUMAN PRESCRIPTION DRUG LABEL 1 60219-1076 TABLET 50 mg ORAL ANDA 19 sections
AZATHIOPRINE HUMAN PRESCRIPTION DRUG LABEL 1 60219-2036 TABLET 75 mg ORAL ANDA 19 sections
AZATHIOPRINE HUMAN PRESCRIPTION DRUG LABEL 1 60219-2037 TABLET 100 mg ORAL ANDA 19 sections
IMURAN HUMAN PRESCRIPTION DRUG LABEL 1 65483-590 TABLET 50 mg ORAL NDA 23 sections
Azasan HUMAN PRESCRIPTION DRUG LABEL 1 65649-231 TABLET 75 mg ORAL ANDA 13 sections
Azasan HUMAN PRESCRIPTION DRUG LABEL 1 65649-241 TABLET 100 mg ORAL ANDA 13 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 65841-602 TABLET 50 mg ORAL ANDA 1 sections
Azathioprine Human Prescription Drug Label 1 67877-492 TABLET 25 mg ORAL ANDA 21 sections
Azathioprine Human Prescription Drug Label 1 67877-492 TABLET 25 mg ORAL ANDA 21 sections
Azathioprine Human Prescription Drug Label 1 67877-493 TABLET 50 mg ORAL ANDA 21 sections
Azathioprine Human Prescription Drug Label 1 67877-493 TABLET 50 mg ORAL ANDA 21 sections
Azathioprine Human Prescription Drug Label 1 67877-494 TABLET 75 mg ORAL ANDA 21 sections
Azathioprine Human Prescription Drug Label 1 67877-494 TABLET 75 mg ORAL ANDA 21 sections
Azathioprine Human Prescription Drug Label 1 67877-495 TABLET 100 mg ORAL ANDA 21 sections
Azathioprine Human Prescription Drug Label 1 67877-495 TABLET 100 mg ORAL ANDA 21 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 68084-229 TABLET 50 mg ORAL ANDA 20 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 68382-003 TABLET 50 1 ORAL ANDA 20 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 68382-118 TABLET 25 1 ORAL ANDA 20 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 68382-119 TABLET 75 1 ORAL ANDA 20 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 68382-120 TABLET 100 1 ORAL ANDA 20 sections
Azathioprine HUMAN PRESCRIPTION DRUG LABEL 1 68462-502 TABLET 50 mg ORAL ANDA 14 sections