azathioprine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	269	446-86-6

Description:

Molecule

Description

Molfile Inchi Smiles Synonyms: BW 57-322 azathioprine sulfate azathioprine azamune azanin azathioprin azathropine azothioprine azathioprine sodium

An immunosuppressive agent used in combination with cyclophosphamide and hydroxychloroquine in the treatment of rheumatoid arthritis. According to the Fourth Annual Report on Carcinogens (NTP 85-002, 1985), this substance has been listed as a known carcinogen. (Merck Index, 11th ed) Molecular weight: 277.26 Formula: C9H7N7O2S CLOGP: 0.51 LIPINSKI: 0 HAC: 9 HDO: 1 TPSA: 115.42 ALOGS: -2.41 ROTB: 3 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Drug dosage:

Dose	Unit	Route
0.15	g	O
0.15	g	P

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	1	Benet LZ, Broccatelli F, Oprea TI
S (Water solubility)	10 mg/mL	Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine)	1 %	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	18.03 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability)	60 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

Date	Agency	Company	Orphan
March 20, 1968	FDA	PROMETHEUS LABS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Drug ineffective	2298.57	35.09	951	4948	100673	2251513
Rheumatoid arthritis	1316.16	35.09	413	5486	18727	2333459
Drug intolerance	1285.82	35.09	376	5523	13341	2338845
Treatment failure	881.55	35.09	244	5655	6995	2345191
Blood iron abnormal	762.95	35.09	116	5783	58	2352128
Exposure during pregnancy	672.10	35.09	270	5629	24949	2327237
Pancytopenia	652.11	35.09	215	5684	11237	2340949
Maternal exposure during pregnancy	638.97	35.09	226	5673	14637	2337549
Product use in unapproved indication	572.74	35.09	194	5705	11006	2341180
Drug hypersensitivity	518.87	35.09	272	5627	46371	2305815
Off label use	518.66	35.09	318	5581	73280	2278906
Condition aggravated	459.31	35.09	222	5677	31757	2320429
Pneumonia	440.97	35.09	249	5650	49047	2303139
Cytomegalovirus infection	416.30	35.09	110	5789	2603	2349583
Leukopenia	407.01	35.09	147	5752	10049	2342137
Joint swelling	405.52	35.09	168	5731	16651	2335535
Arthralgia	392.55	35.09	239	5660	54046	2298140
Pyrexia	387.15	35.09	236	5663	53472	2298714
Synovitis	359.11	35.09	98	5801	2628	2349558
Contraindicated product administered	353.70	35.09	99	5800	2922	2349264
Epstein-Barr virus infection	348.22	35.09	80	5819	1031	2351155
Crohn's disease	346.37	35.09	117	5782	6538	2345648
Therapeutic product effect decreased	340.61	35.09	131	5768	10658	2341528
Cushingoid	331.32	35.09	69	5830	541	2351645
Abdominal pain	310.22	35.09	175	5724	34199	2317987
Non-Hodgkin's lymphoma	308.85	35.09	70	5829	845	2351341
Sepsis	303.47	35.09	141	5758	18347	2333839
Haemophagocytic lymphohistiocytosis	295.16	35.09	73	5826	1310	2350876
Post transplant lymphoproliferative disorder	294.50	35.09	61	5838	464	2351722
Nausea	274.33	35.09	258	5641	111931	2240255
Renal impairment	274.30	35.09	110	5789	9982	2342204
Diarrhoea	265.33	35.09	223	5676	83341	2268845
Arthritis	265.21	35.09	107	5792	9861	2342325
Rash	264.72	35.09	194	5705	59364	2292822
Bone erosion	261.36	35.09	56	5843	510	2351676
Weight decreased	259.96	35.09	146	5753	28225	2323961
Progressive multifocal leukoencephalopathy	256.59	35.09	72	5827	2140	2350046
Pancreatitis	247.32	35.09	96	5803	7983	2344203
Premature delivery	242.98	35.09	75	5824	3125	2349061
Therapeutic product effect incomplete	239.29	35.09	101	5798	10430	2341756
Diabetes mellitus	232.74	35.09	90	5809	7405	2344781
Interstitial lung disease	232.65	35.09	91	5808	7721	2344465
Anaemia	232.34	35.09	146	5753	34646	2317540
Foetal exposure during pregnancy	229.17	35.09	81	5818	5171	2347015
Infection	218.96	35.09	112	5787	17917	2334269
Synovial fluid analysis	216.23	35.09	31	5868	0	2352186
Elbow deformity	215.66	35.09	35	5864	44	2352142
Osteoporosis	215.36	35.09	74	5825	4340	2347846
Pneumocystis jirovecii pneumonia	214.46	35.09	63	5836	2210	2349976
SLE arthritis	212.29	35.09	35	5864	52	2352134
Therapeutic response decreased	211.35	35.09	83	5816	7112	2345074
Dyspnoea	201.21	35.09	186	5713	78547	2273639
Demyelination	200.08	35.09	50	5849	936	2351250
Bone marrow failure	197.06	35.09	74	5825	5612	2346574
Cytomegalovirus viraemia	191.36	35.09	42	5857	432	2351754
Tenosynovitis stenosans	190.32	35.09	34	5865	101	2352085
Scleritis	185.66	35.09	38	5861	270	2351916
Kaposi's sarcoma	182.26	35.09	37	5862	251	2351935
Musculoskeletal pain	181.77	35.09	84	5815	10746	2341440
Antinuclear antibody positive	180.84	35.09	47	5852	1035	2351151
Rheumatoid nodule	180.26	35.09	42	5857	576	2351610
Lymphopenia	179.86	35.09	56	5843	2398	2349788
Respiratory failure	178.67	35.09	89	5810	13439	2338747
Neutropenia	178.64	35.09	104	5795	21444	2330742
Premature baby	177.07	35.09	59	5840	3145	2349041
Abortion spontaneous	176.23	35.09	88	5811	13357	2338829
Musculoskeletal stiffness	174.93	35.09	85	5814	12162	2340024
Vomiting	174.76	35.09	165	5734	71437	2280749
Kidney transplant rejection	174.06	35.09	42	5857	675	2351511
Colitis ulcerative	172.55	35.09	56	5843	2746	2349440
Impaired gastric emptying	171.95	35.09	44	5855	909	2351277
Septic shock	171.35	35.09	71	5828	6983	2345203
Urinary tract infection	171.00	35.09	114	5785	29828	2322358
Diffuse large B-cell lymphoma	170.95	35.09	43	5856	827	2351359
Pleuritic pain	167.66	35.09	40	5859	611	2351575
Hypogammaglobulinaemia	167.64	35.09	41	5858	699	2351487
Premature labour	166.77	35.09	51	5848	2055	2350131
Bronchiectasis	166.70	35.09	43	5856	918	2351268
Systemic lupus erythematosus	164.87	35.09	60	5839	4161	2348025
Squamous cell carcinoma	164.82	35.09	46	5853	1337	2350849
C-reactive protein abnormal	159.52	35.09	40	5859	759	2351427
Anaphylactic reaction	155.76	35.09	73	5826	9632	2342554
C-reactive protein increased	155.44	35.09	64	5835	6191	2345995
Epstein-Barr virus associated lymphoproliferative disorder	152.98	35.09	32	5867	256	2351930
Crepitations	151.37	35.09	37	5862	629	2351557
Ulcer	146.61	35.09	45	5854	1835	2350351
Hypertension	146.19	35.09	100	5799	27261	2324925
Gastrointestinal disorder	145.96	35.09	68	5831	8849	2343337
Joint effusion	140.96	35.09	40	5859	1236	2350950
Alopecia	140.75	35.09	90	5809	21911	2330275
Proteinuria	139.81	35.09	48	5851	2802	2349384
Impaired work ability	135.54	35.09	42	5857	1768	2350418
Chest pain	134.34	35.09	96	5803	28041	2324145
Transplant rejection	134.09	35.09	38	5861	1168	2351018
Lung transplant rejection	133.97	35.09	25	5874	101	2352085
Multiple organ dysfunction syndrome	133.57	35.09	61	5838	7580	2344606
Aspergillus infection	133.12	35.09	36	5863	927	2351259
Red blood cell sedimentation rate increased	132.74	35.09	43	5856	2094	2350092
Lung disorder	132.42	35.09	57	5842	6155	2346031
Atelectasis	132.14	35.09	42	5857	1923	2350263
Synovial cyst	131.97	35.09	35	5864	835	2351351
Herpes zoster	131.35	35.09	65	5834	9660	2342526
Basal cell carcinoma	130.81	35.09	45	5854	2642	2349544
Haemoglobin decreased	130.54	35.09	80	5819	18071	2334115
Therapy non-responder	130.14	35.09	61	5838	8043	2344143
Pulmonary fibrosis	127.69	35.09	44	5855	2596	2349590
Fatigue	127.27	35.09	151	5748	84722	2267464
Lupus nephritis	127.01	35.09	28	5871	294	2351892
Tenderness	124.87	35.09	40	5859	1878	2350308
Conjunctivitis	124.01	35.09	42	5857	2351	2349835
Nodule	123.00	35.09	41	5858	2185	2350001
Therapeutic product effect variable	121.31	35.09	24	5875	140	2352046
Transaminases increased	120.99	35.09	49	5850	4538	2347648
Bursitis	120.98	35.09	39	5860	1869	2350317
Flank pain	120.54	35.09	37	5862	1508	2350678
Lymphadenopathy	120.51	35.09	52	5847	5646	2346540
Immunosuppression	120.28	35.09	34	5865	1035	2351151
Disease recurrence	119.81	35.09	45	5854	3406	2348780
Neoplasm malignant	119.38	35.09	50	5849	5043	2347143
Renal failure	118.49	35.09	74	5825	17275	2334911
Muscle fatigue	116.76	35.09	27	5872	357	2351829
Pain	116.46	35.09	124	5775	61733	2290453
Hepatic enzyme increased	116.23	35.09	60	5839	9742	2342444
Drug interaction	115.63	35.09	89	5810	29074	2323112
Colitis	114.82	35.09	49	5850	5177	2347009
Epicondylitis	114.69	35.09	25	5874	248	2351938
Caesarean section	112.48	35.09	45	5854	4036	2348150
Product use issue	112.14	35.09	63	5836	12106	2340080
Hypersensitivity	111.42	35.09	80	5819	23513	2328673
Red blood cell sedimentation rate abnormal	108.47	35.09	27	5872	496	2351690
Staphylococcal infection	107.38	35.09	47	5852	5279	2346907
Photophobia	106.25	35.09	37	5862	2252	2349934
Malaise	105.59	35.09	112	5787	55473	2296713
Lymphoproliferative disorder	104.26	35.09	27	5872	585	2351601
Acute myeloid leukaemia	103.84	35.09	38	5861	2672	2349514
Cushing's syndrome	102.08	35.09	28	5871	761	2351425
Klebsiella infection	101.11	35.09	28	5871	789	2351397
Feeling jittery	100.46	35.09	34	5865	1898	2350288
Toxicity to various agents	98.30	35.09	85	5814	32669	2319517
Mycobacterial infection	97.48	35.09	22	5877	259	2351927
Acute kidney injury	96.80	35.09	79	5820	28043	2324143
Normal newborn	96.62	35.09	30	5869	1270	2350916
Adverse drug reaction	96.16	35.09	50	5849	8233	2343953
Low birth weight baby	96.14	35.09	27	5872	802	2351384
Secondary immunodeficiency	96.00	35.09	18	5881	75	2352111
Erythema	95.81	35.09	75	5824	25084	2327102
Blood cholesterol increased	95.22	35.09	43	5856	5198	2346988
Pancreatitis acute	94.24	35.09	39	5860	3814	2348372
Lower respiratory tract infection	93.81	35.09	43	5856	5381	2346805
Squamous cell carcinoma of skin	93.47	35.09	26	5873	745	2351441
Live birth	92.63	35.09	29	5870	1262	2350924
Varicella zoster virus infection	92.18	35.09	22	5877	336	2351850
Thrombosis	91.51	35.09	50	5849	9094	2343092
Pulmonary tuberculosis	89.92	35.09	26	5873	859	2351327
Fibromyalgia	89.59	35.09	36	5863	3264	2348922
Premature rupture of membranes	89.32	35.09	26	5873	880	2351306
Neck pain	88.02	35.09	46	5853	7651	2344535
Pemphigus	87.50	35.09	24	5875	652	2351534
Disseminated tuberculosis	87.21	35.09	23	5876	536	2351650
Ankylosing spondylitis	86.74	35.09	24	5875	674	2351512
Thrombocytopenia	86.01	35.09	63	5836	19068	2333118
Ocular hyperaemia	85.69	35.09	37	5862	4019	2348167
Cholestasis	85.41	35.09	36	5863	3685	2348501
Pneumonia cytomegaloviral	85.22	35.09	20	5879	283	2351903
Pain in jaw	84.24	35.09	42	5857	6330	2345856
Aspartate aminotransferase increased	84.06	35.09	53	5846	12559	2339627
Mucormycosis	83.94	35.09	21	5878	394	2351792
Myelodysplastic syndrome	83.85	35.09	32	5867	2528	2349658
Dry eye	83.28	35.09	36	5863	3920	2348266
Vasculitis	83.27	35.09	31	5868	2287	2349899
Disease progression	83.02	35.09	59	5840	17036	2335150
B-cell lymphoma	82.98	35.09	23	5876	650	2351536
Skin ulcer	82.39	35.09	36	5863	4023	2348163
Epstein-Barr virus test positive	82.28	35.09	17	5882	127	2352059
Granulomatosis with polyangiitis	81.64	35.09	18	5881	189	2351997
Hepatitis	81.51	35.09	41	5858	6296	2345890
Pain in extremity	81.18	35.09	86	5813	42454	2309732
Staphylococcal sepsis	80.93	35.09	25	5874	1040	2351146
Liver function test abnormal	80.64	35.09	43	5856	7447	2344739
Meningitis cryptococcal	80.54	35.09	18	5881	202	2351984
Angiocentric lymphoma	80.34	35.09	16	5883	97	2352089
Lung infiltration	80.31	35.09	30	5869	2234	2349952
Peritonitis	80.11	35.09	31	5868	2543	2349643
Pruritus	79.85	35.09	86	5813	43254	2308932
Intentional product use issue	79.85	35.09	34	5865	3568	2348618
Groin pain	79.10	35.09	26	5873	1324	2350862
Adverse reaction	78.91	35.09	27	5872	1557	2350629
Disseminated intravascular coagulation	78.86	35.09	33	5866	3317	2348869
Iron deficiency anaemia	78.81	35.09	29	5870	2070	2350116
Pelvic fracture	78.64	35.09	26	5873	1349	2350837
Wheezing	78.30	35.09	40	5859	6344	2345842
Jaundice	77.85	35.09	38	5861	5470	2346716
Fungal endocarditis	77.42	35.09	13	5886	23	2352163
Headache	77.20	35.09	115	5784	80064	2272122
Blood creatinine increased	77.12	35.09	47	5852	10486	2341700
Myalgia	77.02	35.09	64	5835	23269	2328917
Pre-eclampsia	76.35	35.09	26	5873	1478	2350708
Joint stiffness	76.24	35.09	34	5865	3989	2348197
Eye pain	75.97	35.09	36	5863	4855	2347331
Atrial septal defect	75.21	35.09	25	5874	1319	2350867
Visual impairment	74.84	35.09	48	5851	11707	2340479
Exostosis	74.59	35.09	25	5874	1353	2350833
Pseudomonas infection	74.58	35.09	24	5875	1142	2351044
Mycobacterium avium complex infection	73.65	35.09	19	5880	405	2351781
Tuberculosis	73.63	35.09	27	5872	1908	2350278
White blood cell count decreased	73.01	35.09	56	5843	18152	2334034
Carpal tunnel syndrome	72.43	35.09	27	5872	1998	2350188
Foetal growth restriction	71.02	35.09	23	5876	1117	2351069
Eye irritation	70.80	35.09	31	5868	3481	2348705
Gait disturbance	70.60	35.09	60	5839	22485	2329701
Listeriosis	69.36	35.09	16	5883	209	2351977
Anal fistula	68.68	35.09	19	5880	533	2351653
Behcet's syndrome	68.24	35.09	15	5884	155	2352031
Peripheral swelling	68.11	35.09	53	5846	17544	2334642
Clostridium difficile infection	66.45	35.09	28	5871	2862	2349324
Lymphoma	66.06	35.09	25	5874	1929	2350257
JC virus infection	65.02	35.09	15	5884	196	2351990
Hepatic cirrhosis	65.00	35.09	26	5873	2327	2349859
Alanine aminotransferase increased	64.83	35.09	47	5852	13985	2338201
Pre-existing condition improved	64.52	35.09	18	5881	521	2351665
Herpes simplex hepatitis	64.39	35.09	12	5887	48	2352138
Asthenia	64.36	35.09	80	5819	46846	2305340
Candida infection	63.28	35.09	27	5872	2846	2349340
Acute respiratory distress syndrome	62.94	35.09	28	5871	3264	2348922
Urosepsis	62.14	35.09	24	5875	1957	2350229
Foot deformity	62.05	35.09	24	5875	1965	2350221
Joint dislocation	61.70	35.09	22	5877	1434	2350752
Hepatotoxicity	61.44	35.09	28	5871	3453	2348733
Mycobacterium abscessus infection	61.40	35.09	12	5887	65	2352121
Respiratory tract infection	60.56	35.09	29	5870	4000	2348186
Gestational hypertension	59.82	35.09	16	5883	394	2351792
Cough	59.69	35.09	65	5834	33052	2319134
Hepatic failure	59.37	35.09	32	5867	5657	2346529
Rectal cancer metastatic	59.22	35.09	11	5888	43	2352143
Meningoencephalitis viral	59.09	35.09	10	5889	19	2352167
Central nervous system lymphoma	59.08	35.09	14	5885	207	2351979
Histoplasmosis disseminated	59.01	35.09	14	5885	208	2351978
Oral candidiasis	58.78	35.09	23	5876	1942	2350244
Swelling face	58.53	35.09	38	5861	9455	2342731
Mouth ulceration	58.32	35.09	28	5871	3884	2348302
Pleural effusion	58.31	35.09	41	5858	11627	2340559
Plasmablastic lymphoma	58.25	35.09	11	5888	48	2352138
Upper limb fracture	58.03	35.09	25	5874	2698	2349488
Gastrointestinal lymphoma	57.58	35.09	9	5890	7	2352179
Liver transplant rejection	57.39	35.09	15	5884	337	2351849
Chronic kidney disease	56.96	35.09	28	5871	4090	2348096
Immunosuppressant drug level decreased	56.48	35.09	13	5886	168	2352018
Herpes simplex	56.33	35.09	19	5880	1048	2351138
Oesophageal candidiasis	56.03	35.09	17	5882	665	2351521
Large intestinal stenosis	55.98	35.09	15	5884	372	2351814
No adverse event	55.96	35.09	37	5862	9491	2342695
Loss of personal independence in daily activities	55.77	35.09	30	5869	5281	2346905
Dry mouth	55.76	35.09	35	5864	8218	2343968
Rectal haemorrhage	55.75	35.09	31	5868	5825	2346361
Thrombotic microangiopathy	55.74	35.09	20	5879	1327	2350859
Hepatitis E	55.25	35.09	13	5886	186	2352000
Skin lesion	54.57	35.09	27	5872	3998	2348188
Cytomegalovirus colitis	54.50	35.09	14	5885	293	2351893
Influenza	54.39	35.09	41	5858	12937	2339249
Inflammation	54.04	35.09	31	5868	6182	2346004
Necrosis	53.50	35.09	18	5881	985	2351201
Corynebacterium infection	53.25	35.09	11	5888	82	2352104
Hepatosplenomegaly	52.87	35.09	15	5884	462	2351724
Drug resistance	52.36	35.09	23	5876	2601	2349585
Abscess rupture	52.17	35.09	10	5889	48	2352138
Patent ductus arteriosus	51.96	35.09	16	5883	658	2351528
Lupus myocarditis	51.90	35.09	8	5891	5	2352181
Tuberculosis of central nervous system	51.83	35.09	10	5889	50	2352136
Respiratory disorder	51.75	35.09	26	5873	3978	2348208
Hepatosplenic T-cell lymphoma	51.67	35.09	10	5889	51	2352135
Ascites	51.46	35.09	29	5870	5591	2346595
Aplastic anaemia	51.31	35.09	17	5882	887	2351299
Autoimmune hepatitis	51.27	35.09	20	5879	1675	2350511
Eye disorder	50.92	35.09	24	5875	3195	2348991
Cervical dysplasia	50.85	35.09	16	5883	707	2351479
Osteoarthritis	50.83	35.09	31	5868	6915	2345271
Cytomegalovirus chorioretinitis	50.79	35.09	12	5887	175	2352011
Drug-induced liver injury	50.70	35.09	25	5874	3674	2348512
Nocardiosis	50.57	35.09	13	5886	273	2351913
Strongyloidiasis	50.54	35.09	12	5887	179	2352007
Hodgkin's disease	50.21	35.09	15	5884	556	2351630
Anterograde amnesia	50.19	35.09	11	5888	112	2352074
Renal cell carcinoma	50.13	35.09	16	5883	741	2351445
Drug ineffective for unapproved indication	49.66	35.09	23	5876	2943	2349243
Bronchopulmonary aspergillosis	49.56	35.09	17	5882	987	2351199
Drug reaction with eosinophilia and systemic symptoms	49.24	35.09	28	5871	5490	2346696
Night sweats	49.00	35.09	24	5875	3476	2348710
Anogenital warts	48.39	35.09	11	5888	134	2352052
Diarrhoea haemorrhagic	47.98	35.09	18	5881	1355	2350831
Viral infection	47.95	35.09	26	5873	4650	2347536
Brain abscess	47.93	35.09	13	5886	338	2351848
Oesophageal squamous cell carcinoma	47.90	35.09	9	5890	38	2352148
Gestational diabetes	47.80	35.09	18	5881	1369	2350817
Sinusitis	47.69	35.09	42	5857	16484	2335702
Nephrotic syndrome	47.68	35.09	17	5882	1107	2351079
Bursitis infective	47.46	35.09	10	5889	83	2352103
Nodular regenerative hyperplasia	47.46	35.09	10	5889	83	2352103
Bacteraemia	47.38	35.09	19	5880	1711	2350475
Atypical haemolytic uraemic syndrome	47.36	35.09	10	5889	84	2352102
Aplasia pure red cell	47.13	35.09	15	5884	688	2351498
Posterior reversible encephalopathy syndrome	47.10	35.09	21	5878	2459	2349727
Bone marrow toxicity	46.91	35.09	13	5886	367	2351819
Sciatica	46.89	35.09	20	5879	2105	2350081
Appendicitis	46.83	35.09	17	5882	1166	2351020
Nonalcoholic fatty liver disease	46.65	35.09	9	5890	45	2352141
Psoriatic arthropathy	46.46	35.09	24	5875	3890	2348296
Encephalitis	46.41	35.09	17	5882	1197	2350989
Hepatic fibrosis	46.23	35.09	14	5885	544	2351642
Enterococcal infection	46.16	35.09	15	5884	736	2351450
Infectious mononucleosis	45.87	35.09	13	5886	399	2351787
Extrapulmonary tuberculosis	45.55	35.09	9	5890	52	2352134
Drug level below therapeutic	45.17	35.09	13	5886	422	2351764
Immunosuppressant drug level increased	45.17	35.09	13	5886	422	2351764
Abdominal tenderness	45.04	35.09	16	5883	1031	2351155
Lupus vasculitis	44.96	35.09	8	5891	23	2352163
Haematochezia	44.93	35.09	26	5873	5269	2346917
Myositis	44.83	35.09	17	5882	1318	2350868
Acute febrile neutrophilic dermatosis	44.56	35.09	13	5886	443	2351743
Histoplasmosis	44.46	35.09	12	5887	306	2351880
Abdominal pain upper	44.43	35.09	46	5853	22054	2330132
Abscess	44.31	35.09	20	5879	2411	2349775
Dehydration	44.10	35.09	46	5853	22249	2329937
Therapeutic response unexpected	43.91	35.09	23	5876	3836	2348350
Herpes virus infection	43.89	35.09	15	5884	861	2351325
Abdominal pain lower	43.74	35.09	21	5878	2912	2349274
Hydrops foetalis	43.70	35.09	9	5890	66	2352120
Overlap syndrome	43.58	35.09	9	5890	67	2352119
Hypoxia	43.55	35.09	27	5872	6200	2345986
Nephropathy toxic	43.07	35.09	16	5883	1172	2351014
Gastroenteritis	42.89	35.09	21	5878	3039	2349147
Acute hepatic failure	42.71	35.09	20	5879	2622	2349564
Obliterative bronchiolitis	42.47	35.09	11	5888	238	2351948
Actinic keratosis	42.22	35.09	12	5887	372	2351814
Pneumothorax	42.07	35.09	19	5880	2293	2349893
Osteonecrosis	41.87	35.09	28	5871	7314	2344872
Abdominal discomfort	41.86	35.09	40	5859	17416	2334770
Transient hypogammaglobulinaemia of infancy	41.84	35.09	6	5893	0	2352186
Upper respiratory tract infection	41.67	35.09	30	5869	8821	2343365
Microsporidia infection	41.47	35.09	8	5891	40	2352146
Localised infection	41.10	35.09	20	5879	2856	2349330
Sepsis neonatal	40.85	35.09	9	5890	94	2352092
Haemodialysis	40.84	35.09	18	5881	2051	2350135
Liver disorder	40.33	35.09	26	5873	6388	2345798
Anal ulcer	40.27	35.09	9	5890	101	2352085
Neutropenic sepsis	40.05	35.09	16	5883	1426	2350760
Jaw fracture	39.70	35.09	12	5887	463	2351723
Metastatic malignant melanoma	39.40	35.09	11	5888	319	2351867
Papilloma viral infection	39.37	35.09	11	5888	320	2351866
Epstein-Barr virus associated lymphoma	39.30	35.09	8	5891	55	2352131
Myopathy	39.01	35.09	16	5883	1527	2350659
Hepatic steatosis	39.00	35.09	20	5879	3193	2348993
Foetal death	38.92	35.09	17	5882	1895	2350291
Pneumocystis jirovecii infection	38.81	35.09	10	5889	212	2351974
Pulmonary mass	38.80	35.09	17	5882	1909	2350277
Uveitis	38.40	35.09	16	5883	1589	2350597
Swelling	38.32	35.09	37	5862	16313	2335873
Malignant melanoma	38.25	35.09	17	5882	1975	2350211
Hair follicle tumour benign	38.18	35.09	7	5892	25	2352161
Chronic allograft nephropathy	38.04	35.09	9	5890	132	2352054
Sjogren's syndrome	37.93	35.09	14	5885	1007	2351179
Respiratory distress	37.80	35.09	23	5876	5106	2347080
Hypotension	37.69	35.09	51	5848	32385	2319801
Post procedural complication	37.63	35.09	19	5880	2935	2349251
Skin mass	37.61	35.09	14	5885	1031	2351155
Pericardial effusion	37.54	35.09	21	5878	3988	2348198
Agranulocytosis	37.48	35.09	20	5879	3462	2348724
Blood alkaline phosphatase increased	37.42	35.09	25	5874	6520	2345666
Laryngeal stenosis	37.29	35.09	8	5891	73	2352113
Enterococcal sepsis	37.19	35.09	9	5890	146	2352040
Enteritis	37.08	35.09	14	5885	1072	2351114
Cytomegalovirus test positive	36.94	35.09	11	5888	403	2351783
Aphthous ulcer	36.86	35.09	15	5884	1403	2350783
T-cell lymphoma	36.74	35.09	9	5890	154	2352032
Pneumatosis intestinalis	36.71	35.09	11	5888	412	2351774
Impaired healing	36.67	35.09	23	5876	5388	2346798
Dermatomyositis	36.35	35.09	11	5888	426	2351760
Tachycardia	36.34	35.09	36	5863	16373	2335813
Cellulitis	36.19	35.09	28	5871	9173	2343013
Porokeratosis	35.80	35.09	7	5892	38	2352148
Weight increased	35.34	35.09	41	5858	22296	2329890
Polyomavirus-associated nephropathy	35.33	35.09	9	5890	182	2352004
Heart transplant rejection	35.30	35.09	8	5891	96	2352090
Pregnancy	35.27	35.09	26	5873	7923	2344263
Intentional overdose	35.13	35.09	30	5869	11291	2340895
Fibrosis	35.11	35.09	11	5888	479	2351707

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Drug ineffective	958.35	40.48	493	4192	63308	1678788
Pyrexia	568.27	40.48	315	4370	46085	1696011
Pancytopenia	552.49	40.48	203	4482	11154	1730942
Pneumonia	493.28	40.48	287	4398	45895	1696201
Leukopenia	481.14	40.48	170	4515	8310	1733786
Drug eruption	478.52	40.48	132	4553	2794	1739302
Hepatic function abnormal	448.03	40.48	154	4531	6920	1735176
Pneumocystis jirovecii pneumonia	406.98	40.48	112	4573	2344	1739752
Kaposi's sarcoma	405.82	40.48	91	4594	776	1741320
Product use in unapproved indication	401.30	40.48	153	4532	9269	1732827
Cytomegalovirus infection	396.05	40.48	117	4568	3184	1738912
Stomatitis	386.62	40.48	129	4556	5275	1736821
Hypersensitivity	372.02	40.48	149	4536	10295	1731801
Crohn's disease	370.33	40.48	120	4565	4467	1737629
Epistaxis	364.82	40.48	138	4547	8168	1733928
Post transplant lymphoproliferative disorder	363.44	40.48	81	4604	669	1741427
Hepatosplenic T-cell lymphoma	353.78	40.48	60	4625	75	1742021
Pain in extremity	344.04	40.48	167	4518	18305	1723791
Sepsis	327.05	40.48	164	4521	19274	1722822
Diffuse large B-cell lymphoma	315.29	40.48	78	4607	1051	1741045
Squamous cell carcinoma	308.30	40.48	85	4600	1786	1740310
Urticaria	300.12	40.48	134	4551	12107	1729989
Muscle spasms	297.05	40.48	131	4554	11490	1730606
Epstein-Barr virus infection	265.77	40.48	68	4617	1057	1741039
Off label use	260.18	40.48	180	4505	38391	1703705
Basal cell carcinoma	233.31	40.48	73	4612	2410	1739686
Colitis ulcerative	231.85	40.48	73	4612	2461	1739635
Disease recurrence	230.50	40.48	73	4612	2509	1739587
Bone marrow failure	230.13	40.48	87	4598	5113	1736983
Foetal exposure during pregnancy	226.94	40.48	91	4594	6268	1735828
Multiple organ dysfunction syndrome	225.71	40.48	101	4584	9141	1732955
Premature baby	225.16	40.48	74	4611	2868	1739228
Haemophagocytic lymphohistiocytosis	220.59	40.48	62	4623	1398	1740698
Treatment failure	214.32	40.48	79	4606	4322	1737774
Nodular regenerative hyperplasia	211.55	40.48	40	4645	125	1741971
Lymphoproliferative disorder	207.01	40.48	47	4638	424	1741672
Squamous cell carcinoma of skin	202.53	40.48	56	4629	1186	1740910
Weight decreased	196.16	40.48	124	4561	22629	1719467
Kidney transplant rejection	186.25	40.48	52	4633	1142	1740954
Anaemia	185.39	40.48	132	4553	29325	1712771
Abdominal pain	179.90	40.48	115	4570	21375	1720721
Transplant rejection	170.92	40.48	50	4635	1304	1740792
Epstein-Barr virus associated lymphoproliferative disorder	159.92	40.48	36	4649	311	1741785
Lymphopenia	158.95	40.48	52	4633	1981	1740115
Progressive multifocal leukoencephalopathy	153.10	40.48	48	4637	1591	1740505
Neutropenia	150.93	40.48	97	4588	18163	1723933
Condition aggravated	149.76	40.48	102	4583	21048	1721048
Thrombocytopenia	146.96	40.48	101	4584	21148	1720948
Respiratory failure	145.02	40.48	87	4598	14418	1727678
Diarrhoea	144.89	40.48	148	4537	53704	1688392
Aspergillus infection	144.23	40.48	44	4641	1329	1740767
Candida infection	140.72	40.48	47	4638	1911	1740185
Septic shock	140.47	40.48	70	4615	8039	1734057
Renal cell carcinoma	136.00	40.48	43	4642	1465	1740631
Bronchopulmonary aspergillosis	134.40	40.48	43	4642	1523	1740573
Renal impairment	133.90	40.48	78	4607	12236	1729860
Renal failure	126.34	40.48	90	4595	19927	1722169
Lymphadenopathy	123.23	40.48	52	4633	4062	1738034
Pancreatitis acute	120.23	40.48	51	4634	4036	1738060
Pancreatitis	118.44	40.48	60	4625	7127	1734969
Herpes zoster	117.94	40.48	52	4633	4521	1737575
C-reactive protein increased	117.49	40.48	56	4629	5829	1736267
Splenomegaly	114.05	40.48	41	4644	2079	1740017
Acute febrile neutrophilic dermatosis	112.97	40.48	27	4658	310	1741786
Cytomegalovirus viraemia	112.91	40.48	30	4655	542	1741554
Human herpesvirus 8 infection	112.09	40.48	22	4663	88	1742008
Lung transplant rejection	110.73	40.48	22	4663	95	1742001
Drug intolerance	109.89	40.48	54	4631	6008	1736088
Drug reaction with eosinophilia and systemic symptoms	109.68	40.48	51	4634	5019	1737077
Immunosuppression	109.42	40.48	32	4653	832	1741264
Colitis	109.30	40.48	48	4637	4132	1737964
Hodgkin's disease	107.97	40.48	31	4654	754	1741342
Drug hypersensitivity	104.63	40.48	72	4613	15063	1727033
Arthralgia	100.93	40.48	84	4601	23360	1718736
Blood creatinine increased	100.31	40.48	68	4617	13878	1728218
Hepatitis cholestatic	100.04	40.48	33	4652	1288	1740808
Low birth weight baby	99.89	40.48	30	4655	857	1741239
Acquired gene mutation	99.53	40.48	22	4663	173	1741923
Portal hypertension	98.42	40.48	28	4657	658	1741438
JC virus infection	97.80	40.48	22	4663	189	1741907
T-cell lymphoma	95.63	40.48	22	4663	211	1741885
Transplant dysfunction	94.92	40.48	24	4661	353	1741743
Acute kidney injury	93.57	40.48	96	4589	34848	1707248
Intestinal perforation	93.47	40.48	33	4652	1586	1740510
Herpes simplex	93.28	40.48	27	4658	676	1741420
Infection	93.03	40.48	62	4623	12298	1729798
Strongyloidiasis	91.79	40.48	24	4661	406	1741690
Nausea	91.63	40.48	114	4571	51082	1691014
Vomiting	91.46	40.48	99	4586	38216	1703880
Gastrointestinal disorder	91.15	40.48	44	4641	4704	1737392
Lower respiratory tract infection	90.36	40.48	41	4644	3810	1738286
Pulmonary tuberculosis	90.34	40.48	29	4656	1037	1741059
Diabetes mellitus	89.16	40.48	49	4636	6859	1735237
B-cell lymphoma	88.76	40.48	27	4658	806	1741290
Hepatic enzyme increased	88.32	40.48	48	4637	6573	1735523
Cytomegalovirus enteritis	87.20	40.48	16	4669	40	1742056
Skin lesion	87.09	40.48	37	4648	2935	1739161
Chills	86.44	40.48	58	4627	11629	1730467
Hepatitis	86.39	40.48	43	4642	4912	1737184
Cushingoid	84.37	40.48	22	4663	368	1741728
Hepatitis B	82.52	40.48	29	4656	1374	1740722
Hepatotoxicity	82.50	40.48	36	4649	3048	1739048
Hepatosplenomegaly	82.45	40.48	24	4661	613	1741483
Pleural effusion	81.83	40.48	55	4630	11055	1731041
Vasculitis	79.25	40.48	29	4656	1546	1740550
Granulomatosis with polyangiitis	78.03	40.48	17	4668	124	1741972
Epstein-Barr virus associated lymphoma	77.95	40.48	16	4669	84	1742012
Epstein-Barr virus test positive	77.91	40.48	17	4668	125	1741971
Nocardiosis	77.48	40.48	22	4663	513	1741583
Disseminated tuberculosis	77.28	40.48	22	4663	518	1741578
Non-Hodgkin's lymphoma	77.18	40.48	25	4660	920	1741176
Pemphigus	77.10	40.48	19	4666	250	1741846
Osteoporosis	75.90	40.48	28	4657	1527	1740569
Transaminases increased	74.27	40.48	36	4649	3881	1738215
Histoplasmosis disseminated	73.17	40.48	18	4667	235	1741861
Night sweats	72.24	40.48	30	4655	2246	1739850
Chronic allograft nephropathy	71.69	40.48	17	4668	188	1741908
Haemodialysis	71.47	40.48	31	4654	2585	1739511
Mucormycosis	70.23	40.48	22	4663	725	1741371
Acute myeloid leukaemia	70.14	40.48	32	4653	3009	1739087
Therapy non-responder	68.82	40.48	40	4645	6226	1735870
Therapeutic product effect decreased	68.63	40.48	40	4645	6257	1735839
Cytomegalovirus colitis	68.48	40.48	18	4667	311	1741785
Hepatic failure	68.34	40.48	39	4646	5864	1736232
Obliterative bronchiolitis	68.20	40.48	17	4668	235	1741861
Non-cirrhotic portal hypertension	68.15	40.48	13	4672	43	1742053
Foetal growth restriction	67.90	40.48	21	4664	663	1741433
Meningitis cryptococcal	67.53	40.48	18	4667	329	1741767
Headache	66.95	40.48	80	4605	34296	1707800
Herpes zoster meningoencephalitis	66.63	40.48	13	4672	50	1742046
Complications of transplanted kidney	66.09	40.48	20	4665	586	1741510
Staphylococcal infection	65.19	40.48	35	4650	4672	1737424
Hypogammaglobulinaemia	65.04	40.48	20	4665	619	1741477
Disseminated intravascular coagulation	64.87	40.48	32	4653	3582	1738514
Lymphoma	64.59	40.48	27	4658	2055	1740041
Fatigue	63.30	40.48	95	4590	50686	1691410
Therapeutic response decreased	62.76	40.48	36	4649	5464	1736632
Malaise	61.18	40.48	71	4614	29494	1712602
Intentional product use issue	60.78	40.48	28	4657	2691	1739405
Haemoglobin decreased	60.76	40.48	55	4630	17059	1725037
Abscess	59.72	40.48	25	4660	1909	1740187
Central nervous system lesion	59.58	40.48	21	4664	1003	1741093
Viral infection	59.21	40.48	28	4657	2855	1739241
Drug resistance	59.16	40.48	29	4656	3201	1738895
Metastases to liver	59.12	40.48	26	4659	2241	1739855
Neurological symptom	59.07	40.48	19	4666	683	1741413
Squamous cell carcinoma of the tongue	58.94	40.48	12	4673	60	1742036
Dyspnoea	58.72	40.48	93	4592	51966	1690130
Hand deformity	58.67	40.48	15	4670	231	1741865
Cholestasis	58.58	40.48	30	4655	3635	1738461
Platelet count decreased	58.46	40.48	53	4632	16470	1725626
General physical health deterioration	58.41	40.48	48	4637	13070	1729026
Graft versus host disease	57.96	40.48	23	4662	1530	1740566
Clostridium difficile colitis	57.24	40.48	23	4662	1581	1740515
Ascites	56.97	40.48	34	4651	5552	1736544
Visceral leishmaniasis	56.56	40.48	13	4672	124	1741972
Heart transplant rejection	56.54	40.48	14	4671	188	1741908
Cough	55.38	40.48	55	4630	19142	1722954
Product use issue	54.99	40.48	39	4646	8532	1733564
Cryptococcosis	54.95	40.48	15	4670	301	1741795
Clostridium difficile infection	54.92	40.48	23	4662	1758	1740338
Influenza like illness	54.45	40.48	34	4651	6019	1736077
Papilloma viral infection	54.43	40.48	12	4673	93	1742003
Neuroendocrine carcinoma of the skin	54.39	40.48	13	4672	149	1741947
Drug interaction	54.28	40.48	65	4620	27893	1714203
Immunosuppressant drug level increased	53.98	40.48	17	4668	570	1741526
Cushing's syndrome	53.50	40.48	17	4668	587	1741509
Skin cancer	53.49	40.48	21	4664	1358	1740738
Liver disorder	51.56	40.48	32	4653	5604	1736492
Peritonitis	51.38	40.48	25	4660	2714	1739382
Metastases to lymph nodes	51.30	40.48	18	4667	848	1741248
Myopathy	51.21	40.48	22	4663	1791	1740305
Liver function test abnormal	51.09	40.48	32	4653	5694	1736402
Varicella zoster virus infection	50.80	40.48	13	4672	201	1741895
Lung infiltration	50.66	40.48	23	4662	2136	1739960
Joint swelling	50.48	40.48	33	4652	6320	1735776
Polyomavirus-associated nephropathy	49.90	40.48	15	4670	429	1741667
Pneumoperitoneum	49.56	40.48	14	4671	320	1741776
Extrapulmonary tuberculosis	49.46	40.48	10	4675	48	1742048
Liver transplant rejection	49.09	40.48	15	4670	454	1741642
Rash	49.01	40.48	73	4612	38620	1703476
Aplasia pure red cell	48.49	40.48	18	4667	998	1741098
Pulmonary nocardiosis	48.36	40.48	9	4676	25	1742071
Rash erythematous	48.04	40.48	27	4658	3938	1738158
Hepatitis C	47.93	40.48	24	4661	2772	1739324
Diarrhoea haemorrhagic	47.76	40.48	18	4667	1041	1741055
Asthenia	47.66	40.48	68	4617	34602	1707494
Pneumatosis intestinalis	47.51	40.48	15	4670	507	1741589
Red blood cell sedimentation rate increased	47.21	40.48	18	4667	1075	1741021
Chronic myeloid leukaemia	47.13	40.48	16	4669	682	1741414
Myelodysplastic syndrome	47.06	40.48	25	4660	3264	1738832
Infection reactivation	46.94	40.48	11	4674	115	1741981
Cow pox	45.97	40.48	7	4678	1	1742095
Actinic keratosis	45.88	40.48	15	4670	568	1741528
Lymphadenitis	45.78	40.48	13	4672	303	1741793
Mycobacterium chelonae infection	45.41	40.48	10	4675	77	1742019
Mycobacterium avium complex infection	44.91	40.48	13	4672	325	1741771
Lung abscess	44.81	40.48	14	4671	457	1741639
Functional gastrointestinal disorder	44.72	40.48	13	4672	330	1741766
Epstein Barr virus positive mucocutaneous ulcer	44.72	40.48	9	4676	42	1742054
Skin necrosis	44.53	40.48	16	4669	808	1741288
Escherichia sepsis	44.30	40.48	15	4670	634	1741462
Interstitial lung disease	44.24	40.48	36	4649	9660	1732436
Lymphocyte count decreased	44.07	40.48	21	4664	2177	1739919
Respiratory tract infection fungal	42.99	40.48	10	4675	101	1741995
Cellulitis	42.80	40.48	30	4655	6438	1735658
Lung neoplasm	42.44	40.48	15	4670	722	1741374
Nephropathy toxic	42.38	40.48	19	4666	1713	1740383
Frequent bowel movements	42.00	40.48	18	4667	1456	1740640
Neutropenic sepsis	41.79	40.48	18	4667	1474	1740622
Large intestinal stenosis	41.65	40.48	12	4673	295	1741801
Escherichia infection	41.62	40.48	16	4669	977	1741119
Ileal stenosis	41.61	40.48	12	4673	296	1741800
Intestinal fistula	41.52	40.48	11	4674	196	1741900
Opportunistic infection	40.58	40.48	12	4673	324	1741772
Fungal infection	40.49	40.48	20	4665	2242	1739854

Pharmacologic Action:

Source	Code	Description
ATC	L04AX01	ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS IMMUNOSUPPRESSANTS IMMUNOSUPPRESSANTS Other immunosuppressants
FDA MoA	N0000000233	Nucleic Acid Synthesis Inhibitors
FDA Chemical/Ingredient	N0000175459	Nucleoside Analog
FDA EPC	N0000175712	Purine Antimetabolite
FDA Chemical/Ingredient	N0000008065	Purines
MeSH PA	D000963	Antimetabolites
MeSH PA	D000964	Antimetabolites, Antineoplastic
MeSH PA	D000970	Antineoplastic Agents
MeSH PA	D018501	Antirheumatic Agents
MeSH PA	D007155	Immunologic Factors
MeSH PA	D007166	Immunosuppressive Agents
MeSH PA	D009676	Noxae

Drug Use (View source of the data)

Disease	Relation	SNOMED_ID	DOID
Rheumatoid arthritis	indication	69896004	DOID:7148
Prevention of Kidney Transplant Rejection	indication
Polymyositis	off-label use	31384009
Crohn's disease	off-label use	34000006
Systemic lupus erythematosus	off-label use	55464009	DOID:9074
Ulcerative colitis	off-label use	64766004	DOID:8577
Pemphigus	off-label use	65172003	DOID:9182
Autoimmune hepatitis	off-label use	408335007
Prevention of Liver Transplant Rejection	off-label use
Prevention of Cardiac Transplant Rejection	off-label use
Prevention of Lung Transplant Rejection	off-label use
Systemic Dermatomyositis	off-label use
Mycosis	contraindication	3218000	DOID:1564
Viral disease	contraindication	34014006	DOID:934
Hepatic vein thrombosis	contraindication	38739001	DOID:11512
Bacterial infectious disease	contraindication	87628006
Malignant lymphoma	contraindication	118600007	DOID:0060058
Liver function tests abnormal	contraindication	166603001
Acute pancreatitis	contraindication	197456007	DOID:2913
Impaired renal function disorder	contraindication	197663003
Anemia	contraindication	271737000	DOID:2355
Pregnancy, function	contraindication	289908002
Thrombocytopenic disorder	contraindication	302215000	DOID:1588
Bone marrow depression	contraindication	307762000
Hepatosplenic T-cell lymphoma	contraindication	445406001
Protozoal Infection	contraindication
Thiopurine S-Methyltransferase Deficiency	contraindication
Severe Leukopenia	contraindication

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	8.28	acidic
pKa2	3.24	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Thiopurine S-methyltransferase	Enzyme	P51580	TPMT_HUMAN					WOMBAT-PK
Ras-related C3 botulinum toxin substrate 1	Unclassified	P63000	RAC1_HUMAN					WOMBAT-PK
Multidrug resistance-associated protein 4	Transporter	O15439	MRP4_HUMAN					WOMBAT-PK
Multidrug resistance-associated protein 5	Transporter	O15440	MRP5_HUMAN					WOMBAT-PK
ATP-binding cassette sub-family G member 2	Transporter	Q9UNQ0	ABCG2_HUMAN					WOMBAT-PK
DNA	DNA			OTHER				DRUG LABEL	SCIENTIFIC LITERATURE
RNA	RNA			OTHER				DRUG LABEL	SCIENTIFIC LITERATURE

External reference:

ID	Source
D001379	MESH_DESCRIPTOR_UI
4018766	VUID
N0000147069	NUI
C0004482	UMLSCUI
D00238	KEGG_DRUG
111165009	SNOMEDCT_US
4018766	VANDF
1256	RXNORM
6041	MMSL
d00024	MMSL
372574004	SNOMEDCT_US
4234	MMSL
003419	NDDF
AM94R510MS	UNII
55774-33-9	SECONDARY_CAS_RN
CHEMBL1542	ChEMBL_ID
DB00993	DRUGBANK_ID
CHEMBL1200400	ChEMBL_ID
1291	INN_ID
7120	IUPHAR_LIGAND_ID
2265	PUBCHEM_CID

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Azathioprine Sodium	HUMAN PRESCRIPTION DRUG LABEL	1	0143-9566	INJECTION, POWDER, LYOPHILIZED, FOR SOLUTION	100 mg	INTRAVENOUS	ANDA	13 sections
Azathioprine	HUMAN PRESCRIPTION DRUG LABEL	1	0378-1005	TABLET	50 mg	ORAL	ANDA	13 sections
Azathioprine	HUMAN PRESCRIPTION DRUG LABEL	1	0615-7568	TABLET	50 mg	ORAL	ANDA	11 sections
Azathioprine	HUMAN PRESCRIPTION DRUG LABEL	1	21695-484	TABLET	50 mg	ORAL	ANDA	14 sections
Azathioprine	HUMAN PRESCRIPTION DRUG LABEL	1	33261-758	TABLET	50 mg	ORAL	ANDA	14 sections
Azathioprine	HUMAN PRESCRIPTION DRUG LABEL	1	43353-745	TABLET	50 mg	ORAL	ANDA	14 sections
Azathioprine	HUMAN PRESCRIPTION DRUG LABEL	1	51079-620	TABLET	50 mg	ORAL	ANDA	13 sections
Azathioprine	HUMAN PRESCRIPTION DRUG LABEL	1	51407-182	TABLET	50 mg	ORAL	ANDA	13 sections
IMURAN	HUMAN PRESCRIPTION DRUG LABEL	1	54766-590	TABLET	50 mg	ORAL	NDA	14 sections
Azathioprine	HUMAN PRESCRIPTION DRUG LABEL	1	54868-5310	TABLET	50 mg	ORAL	ANDA	14 sections
AZATHIOPRINE	HUMAN PRESCRIPTION DRUG LABEL	1	60219-1076	TABLET	50 mg	ORAL	ANDA	13 sections
IMURAN	HUMAN PRESCRIPTION DRUG LABEL	1	65483-590	TABLET	50 mg	ORAL	NDA	14 sections
Azasan	HUMAN PRESCRIPTION DRUG LABEL	1	65649-231	TABLET	75 mg	ORAL	ANDA	13 sections
Azasan	HUMAN PRESCRIPTION DRUG LABEL	1	65649-241	TABLET	100 mg	ORAL	ANDA	13 sections
Azathioprine	HUMAN PRESCRIPTION DRUG LABEL	1	65841-602	TABLET	50 mg	ORAL	ANDA	14 sections
Azathioprine	HUMAN PRESCRIPTION DRUG LABEL	1	67877-492	TABLET	25 mg	ORAL	ANDA	13 sections
Azathioprine	HUMAN PRESCRIPTION DRUG LABEL	1	67877-493	TABLET	50 mg	ORAL	ANDA	13 sections
Azathioprine	HUMAN PRESCRIPTION DRUG LABEL	1	67877-494	TABLET	75 mg	ORAL	ANDA	13 sections
Azathioprine	HUMAN PRESCRIPTION DRUG LABEL	1	67877-495	TABLET	100 mg	ORAL	ANDA	13 sections
Azathioprine	HUMAN PRESCRIPTION DRUG LABEL	1	68084-229	TABLET	50 mg	ORAL	ANDA	14 sections
Azathioprine	HUMAN PRESCRIPTION DRUG LABEL	1	68382-003	TABLET	50 1	ORAL	ANDA	14 sections
Azathioprine	HUMAN PRESCRIPTION DRUG LABEL	1	68382-118	TABLET	25 1	ORAL	ANDA	14 sections
Azathioprine	HUMAN PRESCRIPTION DRUG LABEL	1	68382-119	TABLET	75 1	ORAL	ANDA	14 sections
Azathioprine	HUMAN PRESCRIPTION DRUG LABEL	1	68382-120	TABLET	100 1	ORAL	ANDA	14 sections
Azathioprine	HUMAN PRESCRIPTION DRUG LABEL	1	68462-502	TABLET	50 mg	ORAL	ANDA	13 sections
Azathioprine	HUMAN PRESCRIPTION DRUG LABEL	1	70771-1139	TABLET	25 1	ORAL	ANDA	1 sections
Azathioprine	HUMAN PRESCRIPTION DRUG LABEL	1	70771-1140	TABLET	75 1	ORAL	ANDA	1 sections
Azathioprine	HUMAN PRESCRIPTION DRUG LABEL	1	70771-1141	TABLET	100 1	ORAL	ANDA	1 sections
AZATHIOPRINE	HUMAN PRESCRIPTION DRUG LABEL	1	71610-124	TABLET	50 mg	ORAL	ANDA	14 sections
Azathioprine	HUMAN PRESCRIPTION DRUG LABEL	1	71610-306	TABLET	50 mg	ORAL	ANDA	14 sections