lobeglitazone 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| peroxisome proliferator activating receptor-gamma (PPAR-gamma) agonists, thiazolidinedione derivatives | 5078 | 607723-33-1 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
putative antidiabetic agent for type 2 diabetes
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 0.50 | mg | O |
ADMET properties:
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| July 4, 2013 | Korean Food and Drug Administration (KFDA) | Chong Kun Dang |
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | A10BD26 | ALIMENTARY TRACT AND METABOLISM DRUGS USED IN DIABETES BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS Combinations of oral blood glucose lowering drugs |
| ATC | A10BG04 | ALIMENTARY TRACT AND METABOLISM DRUGS USED IN DIABETES BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS Thiazolidinediones |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Diabetes mellitus type 2 | indication | 44054006 | DOID:9352 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 6.33 | acidic |
| pKa2 | 5.62 | Basic |
| pKa3 | 1.02 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Peroxisome proliferator-activated receptor gamma | Nuclear hormone receptor | AGONIST | EC50 | 7.75 | SCIENTIFIC LITERATURE | SCIENTIFIC LITERATURE | |||
| Peroxisome proliferator-activated receptor alpha | Nuclear hormone receptor | AGONIST | EC50 | 7.70 | SCIENTIFIC LITERATURE |
External reference:
| ID | Source |
|---|---|
| CHEBI:136052 | CHEBI |
| 8LX | PDB_CHEM_ID |
| CHEMBL3585580 | ChEMBL_ID |
| C546215 | MESH_SUPPLEMENTAL_RECORD_UI |
| 763108-62-9 | SECONDARY_CAS_RN |
| DB09198 | DRUGBANK_ID |
| C2744790 | UMLSCUI |
| CHEMBL3780740 | ChEMBL_ID |
| 8729 | INN_ID |
| 9826451 | PUBCHEM_CID |
| MY89F08K5D | UNII |
Pharmaceutical products:
None