rosiglitazone Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| peroxisome proliferator activating receptor-gamma (PPAR-gamma) agonists, thiazolidinedione derivatives | 2405 | 122320-73-4 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
A thiazolidinedione that functions as a selective agonist for PPAR GAMMA. It improves INSULIN SENSITIVITY in adipose tissue, skeletal muscle, and the liver of patients with TYPE 2 DIABETES MELLITUS.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 6 | mg | O |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
| S (Water solubility) | 0.04 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
| EoM (Fraction excreted unchanged in urine) | 0 % | Benet LZ, Broccatelli F, Oprea TI |
| MRTD (Maximum Recommended Therapeutic Daily Dose) | 0.37 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
| BA (Bioavailability) | 99 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
| Vd (Volume of distribution) | 0.20 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 0.65 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| fu (Fraction unbound in plasma) | 0.00 % | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 3.90 hours | Lombardo F, Berellini G, Obach RS |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| May 25, 1999 | FDA | SB PHARMCO |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Cardiac failure congestive | 22445.87 | 23.62 | 6565 | 37456 | 85185 | 46556856 |
| Myocardial infarction | 19382.97 | 23.62 | 5955 | 38066 | 91573 | 46550468 |
| Coronary artery disease | 8286.92 | 23.62 | 2449 | 41572 | 31303 | 46610738 |
| Cerebrovascular accident | 7793.10 | 23.62 | 3071 | 40950 | 97968 | 46544073 |
| Acute myocardial infarction | 2689.44 | 23.62 | 1041 | 42980 | 30883 | 46611158 |
| Coronary arterial stent insertion | 1555.26 | 23.62 | 390 | 43631 | 2463 | 46639578 |
| Coronary artery bypass | 1477.25 | 23.62 | 363 | 43658 | 2082 | 46639959 |
| Myocardial ischaemia | 1363.76 | 23.62 | 496 | 43525 | 12253 | 46629788 |
| Angina unstable | 1359.17 | 23.62 | 434 | 43587 | 7114 | 46634927 |
| Cardiac disorder | 1241.89 | 23.62 | 670 | 43351 | 43188 | 46598853 |
| Transient ischaemic attack | 1103.22 | 23.62 | 574 | 43447 | 34329 | 46607712 |
| Cardiovascular disorder | 973.03 | 23.62 | 383 | 43638 | 11804 | 46630237 |
| Angina pectoris | 748.63 | 23.62 | 406 | 43615 | 26369 | 46615672 |
| Ischaemic cardiomyopathy | 695.68 | 23.62 | 203 | 43818 | 2407 | 46639634 |
| Heart injury | 633.53 | 23.62 | 161 | 43860 | 1078 | 46640963 |
| Acute coronary syndrome | 620.71 | 23.62 | 264 | 43757 | 9940 | 46632101 |
| Atrial fibrillation | 557.12 | 23.62 | 582 | 43439 | 103008 | 46539033 |
| Arteriosclerosis | 530.34 | 23.62 | 233 | 43788 | 9500 | 46632541 |
| Vascular graft | 521.09 | 23.62 | 126 | 43895 | 666 | 46641375 |
| Cardiomyopathy | 517.75 | 23.62 | 268 | 43753 | 15805 | 46626236 |
| Chest pain | 502.12 | 23.62 | 718 | 43303 | 175606 | 46466435 |
| Drug ineffective | 470.89 | 23.62 | 48 | 43973 | 677790 | 45964251 |
| Arteriosclerosis coronary artery | 433.84 | 23.62 | 192 | 43829 | 7964 | 46634077 |
| Stent placement | 423.71 | 23.62 | 150 | 43871 | 3406 | 46638635 |
| Cardio-respiratory arrest | 357.07 | 23.62 | 356 | 43665 | 59513 | 46582528 |
| Diarrhoea | 335.38 | 23.62 | 62 | 43959 | 559540 | 46082501 |
| Off label use | 317.40 | 23.62 | 9 | 44012 | 379832 | 46262209 |
| Sudden cardiac death | 301.64 | 23.62 | 103 | 43918 | 2092 | 46639949 |
| Cardiac arrest | 287.84 | 23.62 | 389 | 43632 | 90010 | 46552031 |
| Nausea | 241.40 | 23.62 | 179 | 43842 | 687275 | 45954766 |
| Fatigue | 219.37 | 23.62 | 154 | 43867 | 608543 | 46033498 |
| Pyrexia | 216.46 | 23.62 | 35 | 43986 | 348767 | 46293274 |
| Headache | 197.32 | 23.62 | 103 | 43918 | 478249 | 46163792 |
| Rheumatoid arthritis | 195.71 | 23.62 | 7 | 44014 | 240208 | 46401833 |
| Rash | 193.74 | 23.62 | 49 | 43972 | 356463 | 46285578 |
| Arthralgia | 192.66 | 23.62 | 53 | 43968 | 364550 | 46277491 |
| Congestive cardiomyopathy | 177.40 | 23.62 | 93 | 43928 | 5620 | 46636421 |
| Malaise | 175.23 | 23.62 | 48 | 43973 | 331184 | 46310857 |
| Arrhythmia | 167.86 | 23.62 | 185 | 43836 | 34656 | 46607385 |
| Vomiting | 166.21 | 23.62 | 112 | 43909 | 452682 | 46189359 |
| Hypertensive heart disease | 157.68 | 23.62 | 67 | 43954 | 2511 | 46639530 |
| Hypertension | 152.05 | 23.62 | 468 | 43553 | 195888 | 46446153 |
| Drug hypersensitivity | 143.42 | 23.62 | 28 | 43993 | 243797 | 46398244 |
| Pulmonary oedema | 141.74 | 23.62 | 206 | 43815 | 50899 | 46591142 |
| Coronary artery occlusion | 139.70 | 23.62 | 90 | 43931 | 8012 | 46634029 |
| Product dose omission issue | 124.32 | 23.62 | 9 | 44012 | 168511 | 46473530 |
| Drug intolerance | 120.68 | 23.62 | 4 | 44017 | 147045 | 46494996 |
| Pneumonia | 117.87 | 23.62 | 109 | 43912 | 376211 | 46265830 |
| Cough | 109.80 | 23.62 | 40 | 43981 | 230209 | 46411832 |
| Toxicity to various agents | 107.59 | 23.62 | 33 | 43988 | 211733 | 46430308 |
| Peripheral swelling | 107.03 | 23.62 | 12 | 44009 | 158059 | 46483982 |
| Supraventricular tachycardia | 104.13 | 23.62 | 92 | 43929 | 13178 | 46628863 |
| Nasopharyngitis | 103.49 | 23.62 | 12 | 44009 | 153986 | 46488055 |
| Cardiac failure | 103.34 | 23.62 | 231 | 43790 | 79717 | 46562324 |
| Macular oedema | 102.96 | 23.62 | 58 | 43963 | 4043 | 46637998 |
| Infection | 101.86 | 23.62 | 6 | 44015 | 133586 | 46508455 |
| Abdominal pain | 101.46 | 23.62 | 45 | 43976 | 229986 | 46412055 |
| Pruritus | 101.39 | 23.62 | 51 | 43970 | 242301 | 46399740 |
| Catheterisation cardiac | 100.97 | 23.62 | 57 | 43964 | 3990 | 46638051 |
| Sinus node dysfunction | 97.89 | 23.62 | 57 | 43964 | 4232 | 46637809 |
| Mitral valve incompetence | 97.58 | 23.62 | 104 | 43917 | 18748 | 46623293 |
| Ischaemia | 96.25 | 23.62 | 57 | 43964 | 4367 | 46637674 |
| Cerebral infarction | 95.51 | 23.62 | 114 | 43907 | 23252 | 46618789 |
| Cardiac pacemaker insertion | 94.73 | 23.62 | 53 | 43968 | 3646 | 46638395 |
| Somnolence | 94.04 | 23.62 | 17 | 44004 | 156504 | 46485537 |
| Drug interaction | 93.95 | 23.62 | 37 | 43984 | 203057 | 46438984 |
| Lacunar infarction | 92.16 | 23.62 | 51 | 43970 | 3434 | 46638607 |
| Implantable defibrillator insertion | 91.91 | 23.62 | 28 | 43993 | 388 | 46641653 |
| Back pain | 91.19 | 23.62 | 42 | 43979 | 209997 | 46432044 |
| Urinary tract infection | 91.15 | 23.62 | 47 | 43974 | 220219 | 46421822 |
| Silent myocardial infarction | 90.48 | 23.62 | 28 | 43993 | 410 | 46641631 |
| Cardiomegaly | 89.70 | 23.62 | 96 | 43925 | 17386 | 46624655 |
| Abdominal discomfort | 89.57 | 23.62 | 17 | 44004 | 151148 | 46490893 |
| Constipation | 88.64 | 23.62 | 27 | 43994 | 174070 | 46467971 |
| Cardiogenic shock | 87.67 | 23.62 | 92 | 43929 | 16292 | 46625749 |
| Neutropenia | 87.23 | 23.62 | 15 | 44006 | 143189 | 46498852 |
| Aortic stenosis | 86.39 | 23.62 | 53 | 43968 | 4329 | 46637712 |
| Fall | 85.65 | 23.62 | 111 | 43910 | 328986 | 46313055 |
| Alopecia | 83.02 | 23.62 | 25 | 43996 | 162389 | 46479652 |
| Pleural effusion | 80.83 | 23.62 | 215 | 43806 | 82737 | 46559304 |
| Hypotension | 79.27 | 23.62 | 62 | 43959 | 232527 | 46409514 |
| Carotid artery stenosis | 78.84 | 23.62 | 53 | 43968 | 5067 | 46636974 |
| Cardiac assistance device user | 78.44 | 23.62 | 17 | 44004 | 49 | 46641992 |
| Febrile neutropenia | 76.13 | 23.62 | 3 | 44018 | 94624 | 46547417 |
| Sinusitis | 73.94 | 23.62 | 16 | 44005 | 129752 | 46512289 |
| Pain | 73.03 | 23.62 | 220 | 43801 | 476728 | 46165313 |
| Cardiac valve disease | 73.01 | 23.62 | 46 | 43975 | 3938 | 46638103 |
| Ventricular tachycardia | 71.35 | 23.62 | 84 | 43937 | 16883 | 46625158 |
| Erythema | 71.16 | 23.62 | 23 | 43998 | 142797 | 46499244 |
| Injury | 70.60 | 23.62 | 139 | 43882 | 43888 | 46598153 |
| Injection site pain | 70.37 | 23.62 | 9 | 44012 | 107143 | 46534898 |
| Dizziness | 69.45 | 23.62 | 135 | 43886 | 340279 | 46301762 |
| Hypersensitivity | 68.48 | 23.62 | 28 | 43993 | 150293 | 46491748 |
| Pain in extremity | 67.51 | 23.62 | 87 | 43934 | 258593 | 46383448 |
| Condition aggravated | 66.47 | 23.62 | 80 | 43941 | 244972 | 46397069 |
| Insomnia | 65.55 | 23.62 | 37 | 43984 | 164887 | 46477154 |
| Coronary angioplasty | 63.48 | 23.62 | 16 | 44005 | 103 | 46641938 |
| Exposure during pregnancy | 62.34 | 23.62 | 13 | 44008 | 108199 | 46533842 |
| Decreased appetite | 61.91 | 23.62 | 55 | 43966 | 193781 | 46448260 |
| Disease progression | 61.59 | 23.62 | 7 | 44014 | 91293 | 46550748 |
| Hyponatraemia | 60.85 | 23.62 | 11 | 44010 | 101321 | 46540720 |
| Feeling abnormal | 60.79 | 23.62 | 21 | 44000 | 125039 | 46517002 |
| Thrombocytopenia | 60.26 | 23.62 | 22 | 43999 | 126559 | 46515482 |
| Atrioventricular block complete | 60.08 | 23.62 | 53 | 43968 | 7574 | 46634467 |
| White blood cell count decreased | 59.69 | 23.62 | 16 | 44005 | 112215 | 46529826 |
| Joint swelling | 59.47 | 23.62 | 42 | 43979 | 166031 | 46476010 |
| Confusional state | 59.17 | 23.62 | 39 | 43982 | 159853 | 46482188 |
| Pericardial effusion | 58.14 | 23.62 | 94 | 43927 | 25449 | 46616592 |
| Musculoskeletal stiffness | 58.06 | 23.62 | 11 | 44010 | 97982 | 46544059 |
| Oropharyngeal pain | 57.54 | 23.62 | 3 | 44018 | 74165 | 46567876 |
| Influenza | 57.41 | 23.62 | 8 | 44013 | 89262 | 46552779 |
| Platelet count decreased | 55.63 | 23.62 | 13 | 44008 | 100011 | 46542030 |
| Urticaria | 55.26 | 23.62 | 21 | 44000 | 117871 | 46524170 |
| Dehydration | 54.98 | 23.62 | 42 | 43979 | 159498 | 46482543 |
| Brain stem infarction | 54.88 | 23.62 | 23 | 43998 | 832 | 46641209 |
| Abdominal pain upper | 54.36 | 23.62 | 35 | 43986 | 145270 | 46496771 |
| Therapeutic product effect decreased | 54.08 | 23.62 | 7 | 44014 | 82594 | 46559447 |
| Intracardiac thrombus | 53.53 | 23.62 | 31 | 43990 | 2277 | 46639764 |
| Cardiac operation | 51.93 | 23.62 | 32 | 43989 | 2634 | 46639407 |
| Overdose | 51.54 | 23.62 | 16 | 44005 | 101963 | 46540078 |
| Psoriasis | 50.65 | 23.62 | 7 | 44014 | 78597 | 46563444 |
| Ischaemic stroke | 50.14 | 23.62 | 70 | 43951 | 16652 | 46625389 |
| Cerebrovascular disorder | 49.52 | 23.62 | 32 | 43989 | 2862 | 46639179 |
| Inappropriate schedule of product administration | 49.29 | 23.62 | 3 | 44018 | 65010 | 46577031 |
| Angioplasty | 49.21 | 23.62 | 24 | 43997 | 1243 | 46640798 |
| Herpes zoster | 48.95 | 23.62 | 4 | 44017 | 67868 | 46574173 |
| Chills | 48.65 | 23.62 | 15 | 44006 | 96017 | 46546024 |
| Bronchitis | 47.83 | 23.62 | 20 | 44001 | 105959 | 46536082 |
| Oxygen saturation decreased | 47.42 | 23.62 | 5 | 44016 | 69159 | 46572882 |
| Stomatitis | 46.66 | 23.62 | 5 | 44016 | 68292 | 46573749 |
| Diastolic dysfunction | 46.19 | 23.62 | 39 | 43982 | 5253 | 46636788 |
| General physical health deterioration | 45.94 | 23.62 | 26 | 43995 | 115743 | 46526298 |
| Coronary artery stenosis | 45.87 | 23.62 | 37 | 43984 | 4676 | 46637365 |
| Asthenia | 45.71 | 23.62 | 146 | 43875 | 310929 | 46331112 |
| Cardiopulmonary failure | 44.90 | 23.62 | 33 | 43988 | 3636 | 46638405 |
| Injection site erythema | 44.85 | 23.62 | 8 | 44013 | 74419 | 46567622 |
| Hyperlipidaemia | 44.63 | 23.62 | 70 | 43951 | 18469 | 46623572 |
| Arthropathy | 43.32 | 23.62 | 13 | 44008 | 84687 | 46557354 |
| Thalamic infarction | 43.00 | 23.62 | 17 | 44004 | 528 | 46641513 |
| Haemoglobin decreased | 41.86 | 23.62 | 36 | 43985 | 128913 | 46513128 |
| Arterial occlusive disease | 41.10 | 23.62 | 35 | 43986 | 4769 | 46637272 |
| Paraesthesia | 40.34 | 23.62 | 31 | 43990 | 117406 | 46524635 |
| Acute kidney injury | 40.27 | 23.62 | 103 | 43918 | 235752 | 46406289 |
| Hepatic enzyme increased | 39.28 | 23.62 | 14 | 44007 | 81773 | 46560268 |
| Weight decreased | 39.23 | 23.62 | 88 | 43933 | 210761 | 46431280 |
| Hypokalaemia | 39.09 | 23.62 | 17 | 44004 | 88007 | 46554034 |
| Pulmonary hypertension | 38.85 | 23.62 | 97 | 43924 | 35896 | 46606145 |
| Cardiac death | 38.49 | 23.62 | 16 | 44005 | 567 | 46641474 |
| Pancytopenia | 38.46 | 23.62 | 16 | 44005 | 85042 | 46556999 |
| Heart rate irregular | 37.74 | 23.62 | 65 | 43956 | 18526 | 46623515 |
| Memory impairment | 37.55 | 23.62 | 13 | 44008 | 77324 | 46564717 |
| Arthritis | 37.53 | 23.62 | 13 | 44008 | 77303 | 46564738 |
| Ventricular fibrillation | 37.30 | 23.62 | 50 | 43971 | 11446 | 46630595 |
| Blindness | 37.20 | 23.62 | 62 | 43959 | 17207 | 46624834 |
| Flushing | 36.72 | 23.62 | 8 | 44013 | 64606 | 46577435 |
| Peripheral vascular disorder | 36.40 | 23.62 | 36 | 43985 | 5941 | 46636100 |
| Oedema | 36.17 | 23.62 | 142 | 43879 | 66929 | 46575112 |
| Musculoskeletal pain | 35.43 | 23.62 | 11 | 44010 | 70117 | 46571924 |
| Migraine | 35.35 | 23.62 | 11 | 44010 | 70015 | 46572026 |
| Lower respiratory tract infection | 35.27 | 23.62 | 5 | 44016 | 55084 | 46586957 |
| Tricuspid valve incompetence | 34.71 | 23.62 | 53 | 43968 | 13664 | 46628377 |
| Gastrointestinal disorder | 34.63 | 23.62 | 7 | 44014 | 59569 | 46582472 |
| Carotid artery disease | 34.62 | 23.62 | 21 | 44000 | 1680 | 46640361 |
| Cor pulmonale | 34.52 | 23.62 | 22 | 43999 | 1921 | 46640120 |
| Rhinorrhoea | 33.84 | 23.62 | 3 | 44018 | 47662 | 46594379 |
| Intentional overdose | 33.15 | 23.62 | 10 | 44011 | 64934 | 46577107 |
| Contusion | 32.80 | 23.62 | 21 | 44000 | 87466 | 46554575 |
| Blood pressure increased | 32.57 | 23.62 | 43 | 43978 | 126623 | 46515418 |
| Neuropathy peripheral | 32.50 | 23.62 | 23 | 43998 | 90870 | 46551171 |
| Myalgia | 32.46 | 23.62 | 41 | 43980 | 123047 | 46518994 |
| Wrong technique in product usage process | 32.46 | 23.62 | 6 | 44015 | 54416 | 46587625 |
| Interstitial lung disease | 32.07 | 23.62 | 6 | 44015 | 53943 | 46588098 |
| Diabetes mellitus inadequate control | 31.95 | 23.62 | 50 | 43971 | 13164 | 46628877 |
| Atrial flutter | 31.55 | 23.62 | 41 | 43980 | 9107 | 46632934 |
| Agitation | 31.20 | 23.62 | 7 | 44014 | 55408 | 46586633 |
| Intentional product misuse | 30.83 | 23.62 | 4 | 44017 | 47124 | 46594917 |
| Haemorrhage | 30.76 | 23.62 | 7 | 44014 | 54862 | 46587179 |
| Asthma | 30.38 | 23.62 | 25 | 43996 | 91517 | 46550524 |
| Abortion spontaneous | 30.32 | 23.62 | 3 | 44018 | 43643 | 46598398 |
| Upper respiratory tract infection | 30.31 | 23.62 | 11 | 44010 | 63545 | 46578496 |
| Neutrophil count decreased | 30.12 | 23.62 | 3 | 44018 | 43423 | 46598618 |
| Tremor | 30.00 | 23.62 | 39 | 43982 | 115600 | 46526441 |
| Anaphylactic reaction | 29.33 | 23.62 | 7 | 44014 | 53105 | 46588936 |
| Leukopenia | 29.10 | 23.62 | 14 | 44007 | 68329 | 46573712 |
| Atrioventricular block | 29.10 | 23.62 | 34 | 43987 | 6777 | 46635264 |
| Multiple sclerosis relapse | 28.99 | 23.62 | 3 | 44018 | 42122 | 46599919 |
| Dysphagia | 28.38 | 23.62 | 19 | 44002 | 77293 | 46564748 |
| Alanine aminotransferase increased | 28.32 | 23.62 | 25 | 43996 | 88426 | 46553615 |
| Renal failure | 27.84 | 23.62 | 193 | 43828 | 113401 | 46528640 |
| Dyspepsia | 27.70 | 23.62 | 15 | 44006 | 68457 | 46573584 |
| Seizure | 27.53 | 23.62 | 46 | 43975 | 123008 | 46519033 |
| Injection site swelling | 27.42 | 23.62 | 3 | 44018 | 40324 | 46601717 |
| Therapeutic response decreased | 27.42 | 23.62 | 4 | 44017 | 43141 | 46598900 |
| Influenza like illness | 27.39 | 23.62 | 10 | 44011 | 57560 | 46584481 |
| Productive cough | 27.39 | 23.62 | 7 | 44014 | 50708 | 46591333 |
| Mitral valve disease | 27.30 | 23.62 | 20 | 44001 | 2192 | 46639849 |
| Nasal congestion | 27.25 | 23.62 | 6 | 44015 | 48107 | 46593934 |
| Injection site reaction | 27.03 | 23.62 | 6 | 44015 | 47843 | 46594198 |
| Bone pain | 26.25 | 23.62 | 6 | 44015 | 46884 | 46595157 |
| Epistaxis | 26.14 | 23.62 | 14 | 44007 | 64291 | 46577750 |
| Dry skin | 25.61 | 23.62 | 4 | 44017 | 41012 | 46601029 |
| Dry mouth | 25.36 | 23.62 | 10 | 44011 | 54916 | 46587125 |
| Suicidal ideation | 24.85 | 23.62 | 11 | 44010 | 56371 | 46585670 |
| Delirium | 24.74 | 23.62 | 3 | 44018 | 37225 | 46604816 |
| Cognitive disorder | 24.44 | 23.62 | 3 | 44018 | 36880 | 46605161 |
| Gait disturbance | 24.34 | 23.62 | 64 | 43957 | 145199 | 46496842 |
| Multiple fractures | 24.13 | 23.62 | 28 | 43993 | 5539 | 46636502 |
| Muscle spasms | 24.02 | 23.62 | 50 | 43971 | 123063 | 46518978 |
| Gastrooesophageal reflux disease | 23.81 | 23.62 | 21 | 44000 | 74323 | 46567718 |
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Myocardial infarction | 27543.87 | 25.61 | 9959 | 51268 | 115666 | 29775585 |
| Cardiac failure congestive | 20478.07 | 25.61 | 7257 | 53970 | 77150 | 29814101 |
| Coronary artery disease | 12821.55 | 25.61 | 4500 | 56727 | 45212 | 29846039 |
| Cerebrovascular accident | 7845.16 | 25.61 | 3664 | 57563 | 79813 | 29811438 |
| Acute myocardial infarction | 3457.87 | 25.61 | 1823 | 59404 | 51116 | 29840135 |
| Coronary artery bypass | 3342.95 | 25.61 | 950 | 60277 | 4212 | 29887039 |
| Coronary arterial stent insertion | 2363.35 | 25.61 | 693 | 60534 | 3501 | 29887750 |
| Cardiac disorder | 1789.57 | 25.61 | 1076 | 60151 | 38817 | 29852434 |
| Myocardial ischaemia | 1769.07 | 25.61 | 811 | 60416 | 16506 | 29874745 |
| Ischaemic cardiomyopathy | 1560.58 | 25.61 | 558 | 60669 | 5739 | 29885512 |
| Angina unstable | 1514.76 | 25.61 | 657 | 60570 | 11653 | 29879598 |
| Cardiovascular disorder | 1427.93 | 25.61 | 609 | 60618 | 10343 | 29880908 |
| Transient ischaemic attack | 1024.40 | 25.61 | 639 | 60588 | 24561 | 29866690 |
| Vascular graft | 821.59 | 25.61 | 241 | 60986 | 1214 | 29890037 |
| Angina pectoris | 790.58 | 25.61 | 578 | 60649 | 28940 | 29862311 |
| Stent placement | 766.56 | 25.61 | 305 | 60922 | 4291 | 29886960 |
| Arteriosclerosis | 743.38 | 25.61 | 387 | 60840 | 10446 | 29880805 |
| Heart injury | 737.14 | 25.61 | 222 | 61005 | 1244 | 29890007 |
| Arteriosclerosis coronary artery | 729.18 | 25.61 | 386 | 60841 | 10790 | 29880461 |
| Cardiomyopathy | 712.68 | 25.61 | 422 | 60805 | 14721 | 29876530 |
| Acute coronary syndrome | 704.28 | 25.61 | 403 | 60824 | 13170 | 29878081 |
| Atrial fibrillation | 585.71 | 25.61 | 898 | 60329 | 107226 | 29784025 |
| Drug ineffective | 472.91 | 25.61 | 68 | 61159 | 340319 | 29550932 |
| Off label use | 447.28 | 25.61 | 14 | 61213 | 249276 | 29641975 |
| Pyrexia | 445.43 | 25.61 | 44 | 61183 | 294445 | 29596806 |
| Diarrhoea | 415.49 | 25.61 | 89 | 61138 | 334014 | 29557237 |
| Sudden cardiac death | 370.85 | 25.61 | 172 | 61055 | 3580 | 29887671 |
| Cardiac arrest | 361.71 | 25.61 | 666 | 60561 | 92184 | 29799067 |
| Chest pain | 324.24 | 25.61 | 731 | 60496 | 116896 | 29774355 |
| Cardio-respiratory arrest | 322.32 | 25.61 | 485 | 60742 | 56821 | 29834430 |
| Pneumonia | 320.67 | 25.61 | 142 | 61085 | 334164 | 29557087 |
| Toxicity to various agents | 291.13 | 25.61 | 18 | 61209 | 177165 | 29714086 |
| Coronary artery occlusion | 286.00 | 25.61 | 213 | 61014 | 10944 | 29880307 |
| Nausea | 244.86 | 25.61 | 153 | 61074 | 296804 | 29594447 |
| Rash | 244.39 | 25.61 | 48 | 61179 | 191841 | 29699410 |
| Vomiting | 234.14 | 25.61 | 79 | 61148 | 219739 | 29671512 |
| Fatigue | 227.05 | 25.61 | 194 | 61033 | 320479 | 29570772 |
| Macular oedema | 220.32 | 25.61 | 109 | 61118 | 2629 | 29888622 |
| Implantable defibrillator insertion | 220.13 | 25.61 | 75 | 61152 | 657 | 29890594 |
| Arrhythmia | 212.91 | 25.61 | 299 | 60928 | 32870 | 29858381 |
| Neutropenia | 202.47 | 25.61 | 16 | 61211 | 128524 | 29762727 |
| Catheterisation cardiac | 198.09 | 25.61 | 95 | 61132 | 2136 | 29889115 |
| Hypotension | 195.29 | 25.61 | 83 | 61144 | 200482 | 29690769 |
| Drug interaction | 188.91 | 25.61 | 86 | 61141 | 199482 | 29691769 |
| Febrile neutropenia | 184.01 | 25.61 | 8 | 61219 | 106685 | 29784566 |
| Acute kidney injury | 177.88 | 25.61 | 179 | 61048 | 273663 | 29617588 |
| Congestive cardiomyopathy | 177.64 | 25.61 | 130 | 61097 | 6497 | 29884754 |
| Silent myocardial infarction | 173.38 | 25.61 | 54 | 61173 | 344 | 29890907 |
| Malaise | 172.48 | 25.61 | 63 | 61164 | 166899 | 29724352 |
| Decreased appetite | 171.87 | 25.61 | 47 | 61180 | 149863 | 29741388 |
| Platelet count decreased | 164.91 | 25.61 | 14 | 61213 | 106115 | 29785136 |
| Thrombocytopenia | 160.82 | 25.61 | 41 | 61186 | 137003 | 29754248 |
| Fall | 159.08 | 25.61 | 87 | 61140 | 181785 | 29709466 |
| Pruritus | 155.83 | 25.61 | 27 | 61200 | 118177 | 29773074 |
| Arthralgia | 151.14 | 25.61 | 45 | 61182 | 135746 | 29755505 |
| Confusional state | 147.69 | 25.61 | 46 | 61181 | 134788 | 29756463 |
| Ischaemia | 147.46 | 25.61 | 100 | 61127 | 4421 | 29886830 |
| Headache | 144.38 | 25.61 | 98 | 61129 | 182208 | 29709043 |
| White blood cell count decreased | 139.29 | 25.61 | 8 | 61219 | 83939 | 29807312 |
| Sepsis | 138.55 | 25.61 | 63 | 61164 | 146332 | 29744919 |
| Constipation | 133.93 | 25.61 | 33 | 61194 | 112873 | 29778378 |
| Abdominal pain | 130.52 | 25.61 | 57 | 61170 | 135597 | 29755654 |
| Lacunar infarction | 127.94 | 25.61 | 80 | 61147 | 3075 | 29888176 |
| Pancytopenia | 127.36 | 25.61 | 13 | 61214 | 85039 | 29806212 |
| Cardiac pacemaker insertion | 125.06 | 25.61 | 73 | 61154 | 2472 | 29888779 |
| Completed suicide | 124.15 | 25.61 | 26 | 61201 | 99466 | 29791785 |
| Cardiac assistance device user | 123.72 | 25.61 | 25 | 61202 | 7 | 29891244 |
| Injury | 123.51 | 25.61 | 185 | 61042 | 21546 | 29869705 |
| Hypertensive heart disease | 123.12 | 25.61 | 71 | 61156 | 2349 | 29888902 |
| Disease progression | 122.79 | 25.61 | 11 | 61216 | 79863 | 29811388 |
| Cardiac operation | 119.62 | 25.61 | 71 | 61156 | 2481 | 29888770 |
| Cough | 118.96 | 25.61 | 54 | 61173 | 125588 | 29765663 |
| Carotid artery stenosis | 117.33 | 25.61 | 88 | 61139 | 4566 | 29886685 |
| Malignant neoplasm progression | 116.60 | 25.61 | 8 | 61219 | 72279 | 29818972 |
| Dehydration | 115.56 | 25.61 | 54 | 61173 | 123485 | 29767766 |
| General physical health deterioration | 111.38 | 25.61 | 33 | 61194 | 99911 | 29791340 |
| Somnolence | 109.57 | 25.61 | 31 | 61196 | 96732 | 29794519 |
| Dizziness | 109.43 | 25.61 | 143 | 61084 | 194766 | 29696485 |
| Anaemia | 109.37 | 25.61 | 160 | 61067 | 207832 | 29683419 |
| Erythema | 108.14 | 25.61 | 15 | 61212 | 77436 | 29813815 |
| Hypertension | 107.65 | 25.61 | 512 | 60715 | 120842 | 29770409 |
| Aortic stenosis | 107.56 | 25.61 | 79 | 61148 | 3969 | 29887282 |
| Peripheral swelling | 107.20 | 25.61 | 4 | 61223 | 61070 | 29830181 |
| Haemoglobin decreased | 106.51 | 25.61 | 50 | 61177 | 114048 | 29777203 |
| Sinus node dysfunction | 104.38 | 25.61 | 76 | 61151 | 3767 | 29887484 |
| Interstitial lung disease | 102.15 | 25.61 | 5 | 61222 | 60192 | 29831059 |
| Back pain | 102.03 | 25.61 | 41 | 61186 | 102555 | 29788696 |
| Overdose | 101.26 | 25.61 | 24 | 61203 | 84313 | 29806938 |
| Infection | 100.32 | 25.61 | 19 | 61208 | 78055 | 29813196 |
| Asthenia | 96.37 | 25.61 | 192 | 61035 | 221098 | 29670153 |
| Insomnia | 93.30 | 25.61 | 37 | 61190 | 93299 | 29797952 |
| Plasma cell myeloma | 92.14 | 25.61 | 4 | 61223 | 53458 | 29837793 |
| Chills | 90.02 | 25.61 | 19 | 61208 | 72319 | 29818932 |
| Peripheral vascular disorder | 89.88 | 25.61 | 79 | 61148 | 5140 | 29886111 |
| Weight decreased | 87.48 | 25.61 | 108 | 61119 | 150813 | 29740438 |
| Urinary tract infection | 84.49 | 25.61 | 23 | 61204 | 73636 | 29817615 |
| Tremor | 83.73 | 25.61 | 25 | 61202 | 75338 | 29815913 |
| Arterial occlusive disease | 83.65 | 25.61 | 68 | 61159 | 3972 | 29887279 |
| Hyponatraemia | 80.90 | 25.61 | 19 | 61208 | 67183 | 29824068 |
| Drug hypersensitivity | 79.33 | 25.61 | 21 | 61206 | 68498 | 29822753 |
| Gastrointestinal haemorrhage | 78.72 | 25.61 | 36 | 61191 | 83410 | 29807841 |
| Condition aggravated | 78.48 | 25.61 | 100 | 61127 | 137766 | 29753485 |
| Leukopenia | 78.09 | 25.61 | 11 | 61216 | 56148 | 29835103 |
| Hallucination | 77.46 | 25.61 | 6 | 61221 | 49053 | 29842198 |
| Hospitalisation | 77.43 | 25.61 | 3 | 61224 | 44316 | 29846935 |
| Hyperlipidaemia | 77.02 | 25.61 | 117 | 61110 | 13790 | 29877461 |
| Neuropathy peripheral | 75.39 | 25.61 | 25 | 61202 | 70450 | 29820801 |
| Pulmonary oedema | 75.19 | 25.61 | 229 | 60998 | 43746 | 29847505 |
| C-reactive protein increased | 72.52 | 25.61 | 4 | 61223 | 43469 | 29847782 |
| Supraventricular tachycardia | 72.49 | 25.61 | 97 | 61130 | 10175 | 29881076 |
| Epistaxis | 72.22 | 25.61 | 11 | 61216 | 52970 | 29838281 |
| Nasopharyngitis | 72.11 | 25.61 | 16 | 61211 | 58833 | 29832418 |
| Coronary angioplasty | 72.10 | 25.61 | 28 | 61199 | 367 | 29890884 |
| Agitation | 71.97 | 25.61 | 12 | 61215 | 54061 | 29837190 |
| Ventricular tachycardia | 71.92 | 25.61 | 154 | 61073 | 23708 | 29867543 |
| Psoriasis | 70.63 | 25.61 | 4 | 61223 | 42502 | 29848749 |
| Cardiogenic shock | 70.58 | 25.61 | 125 | 61102 | 16736 | 29874515 |
| Blood pressure increased | 69.46 | 25.61 | 30 | 61197 | 71898 | 29819353 |
| Cerebrovascular disorder | 69.24 | 25.61 | 46 | 61181 | 1964 | 29889287 |
| Myalgia | 67.88 | 25.61 | 36 | 61191 | 76631 | 29814620 |
| Atrial flutter | 67.84 | 25.61 | 112 | 61115 | 14169 | 29877082 |
| Hypokalaemia | 67.11 | 25.61 | 11 | 61216 | 50181 | 29841070 |
| Hepatic function abnormal | 66.59 | 25.61 | 5 | 61222 | 41940 | 29849311 |
| Cerebral infarction | 65.89 | 25.61 | 158 | 61069 | 26215 | 29865036 |
| Mitral valve incompetence | 65.86 | 25.61 | 106 | 61121 | 13128 | 29878123 |
| Intentional overdose | 65.69 | 25.61 | 5 | 61222 | 41476 | 29849775 |
| Intracardiac thrombus | 65.55 | 25.61 | 48 | 61179 | 2400 | 29888851 |
| Rheumatoid arthritis | 65.14 | 25.61 | 5 | 61222 | 41192 | 29850059 |
| Cardiomegaly | 63.89 | 25.61 | 110 | 61117 | 14399 | 29876852 |
| Septic shock | 63.89 | 25.61 | 25 | 61202 | 63582 | 29827669 |
| Urticaria | 62.70 | 25.61 | 17 | 61210 | 54589 | 29836662 |
| Angioplasty | 62.57 | 25.61 | 34 | 61193 | 1000 | 29890251 |
| Ventricular fibrillation | 61.78 | 25.61 | 111 | 61116 | 15027 | 29876224 |
| Hypersensitivity | 61.70 | 25.61 | 17 | 61210 | 54011 | 29837240 |
| Renal impairment | 61.66 | 25.61 | 49 | 61178 | 84135 | 29807116 |
| Oxygen saturation decreased | 61.60 | 25.61 | 8 | 61219 | 43432 | 29847819 |
| Influenza | 61.52 | 25.61 | 8 | 61219 | 43390 | 29847861 |
| Blood pressure decreased | 61.43 | 25.61 | 11 | 61216 | 47064 | 29844187 |
| Atrioventricular block | 61.20 | 25.61 | 75 | 61152 | 7207 | 29884044 |
| Feeling abnormal | 60.93 | 25.61 | 20 | 61207 | 56736 | 29834515 |
| High density lipoprotein decreased | 60.16 | 25.61 | 51 | 61176 | 3159 | 29888092 |
| White blood cell count increased | 59.52 | 25.61 | 6 | 61221 | 39667 | 29851584 |
| Suicide attempt | 59.33 | 25.61 | 4 | 61223 | 36693 | 29854558 |
| Alanine aminotransferase increased | 58.58 | 25.61 | 40 | 61187 | 74236 | 29817015 |
| Intentional product misuse | 58.42 | 25.61 | 3 | 61224 | 34664 | 29856587 |
| Muscle spasms | 58.05 | 25.61 | 30 | 61197 | 64808 | 29826443 |
| Electrocardiogram QT prolonged | 57.66 | 25.61 | 4 | 61223 | 35831 | 29855420 |
| Pain in extremity | 56.64 | 25.61 | 86 | 61141 | 110135 | 29781116 |
| Seizure | 56.45 | 25.61 | 71 | 61156 | 98404 | 29792847 |
| Rhabdomyolysis | 56.07 | 25.61 | 30 | 61197 | 63550 | 29827701 |
| Cardiac valve disease | 55.57 | 25.61 | 47 | 61180 | 2902 | 29888349 |
| Coronary artery stenosis | 55.54 | 25.61 | 80 | 61147 | 8990 | 29882261 |
| Atrioventricular block complete | 55.20 | 25.61 | 77 | 61150 | 8400 | 29882851 |
| Blindness | 55.09 | 25.61 | 94 | 61133 | 12215 | 29879036 |
| Tachycardia | 52.65 | 25.61 | 44 | 61183 | 73695 | 29817556 |
| Dyspnoea | 52.55 | 25.61 | 433 | 60794 | 332862 | 29558389 |
| Hypoxic-ischaemic encephalopathy | 52.47 | 25.61 | 56 | 61171 | 4631 | 29886620 |
| Basal ganglia infarction | 52.37 | 25.61 | 17 | 61210 | 126 | 29891125 |
| Paraesthesia | 51.90 | 25.61 | 23 | 61204 | 54304 | 29836947 |
| Pneumonia aspiration | 51.13 | 25.61 | 8 | 61219 | 37772 | 29853479 |
| Dysphagia | 51.11 | 25.61 | 26 | 61201 | 56672 | 29834579 |
| Mucosal inflammation | 50.26 | 25.61 | 3 | 61224 | 30491 | 29860760 |
| Blood creatinine increased | 50.19 | 25.61 | 68 | 61159 | 91307 | 29799944 |
| Pleural effusion | 50.04 | 25.61 | 290 | 60937 | 73776 | 29817475 |
| Cor pulmonale | 49.30 | 25.61 | 26 | 61201 | 719 | 29890532 |
| Asthma | 48.19 | 25.61 | 8 | 61219 | 36166 | 29855085 |
| Angiogram | 47.83 | 25.61 | 15 | 61212 | 98 | 29891153 |
| Abdominal discomfort | 47.65 | 25.61 | 20 | 61207 | 48771 | 29842480 |
| Hyperkalaemia | 47.60 | 25.61 | 39 | 61188 | 65971 | 29825280 |
| Ischaemic stroke | 46.71 | 25.61 | 103 | 61124 | 16172 | 29875079 |
| Delirium | 45.99 | 25.61 | 13 | 61214 | 40618 | 29850633 |
| Suicidal ideation | 45.92 | 25.61 | 9 | 61218 | 36105 | 29855146 |
| Colitis | 45.36 | 25.61 | 5 | 61222 | 30815 | 29860436 |
| Injection site pain | 44.40 | 25.61 | 5 | 61222 | 30305 | 29860946 |
| Diabetic retinopathy | 43.91 | 25.61 | 33 | 61194 | 1717 | 29889534 |
| Abdominal pain upper | 43.82 | 25.61 | 38 | 61189 | 62513 | 29828738 |
| Cardiac failure | 43.60 | 25.61 | 306 | 60921 | 83112 | 29808139 |
| Musculoskeletal stiffness | 43.45 | 25.61 | 10 | 61217 | 35871 | 29855380 |
| Bone marrow failure | 43.41 | 25.61 | 5 | 61222 | 29780 | 29861471 |
| Haemorrhage | 43.25 | 25.61 | 20 | 61207 | 46059 | 29845192 |
| Angioedema | 42.82 | 25.61 | 9 | 61218 | 34375 | 29856876 |
| Lethargy | 42.28 | 25.61 | 14 | 61213 | 39505 | 29851746 |
| Loss of consciousness | 41.66 | 25.61 | 61 | 61166 | 79314 | 29811937 |
| Thalamic infarction | 41.05 | 25.61 | 22 | 61205 | 629 | 29890622 |
| Encephalopathy | 41.00 | 25.61 | 8 | 61219 | 32197 | 29859054 |
| Hyperhidrosis | 40.96 | 25.61 | 46 | 61181 | 67044 | 29824207 |
| Muscular weakness | 40.68 | 25.61 | 42 | 61185 | 63603 | 29827648 |
| Respiratory distress | 40.31 | 25.61 | 9 | 61218 | 32963 | 29858288 |
| Urinary retention | 40.21 | 25.61 | 9 | 61218 | 32908 | 29858343 |
| Joint swelling | 40.15 | 25.61 | 23 | 61204 | 46923 | 29844328 |
| International normalised ratio increased | 39.97 | 25.61 | 24 | 61203 | 47715 | 29843536 |
| Pneumonitis | 39.05 | 25.61 | 5 | 61222 | 27449 | 29863802 |
| Cardiac death | 38.90 | 25.61 | 25 | 61202 | 1008 | 29890243 |
| Oropharyngeal pain | 38.63 | 25.61 | 6 | 61221 | 28490 | 29862761 |
| Therapeutic response decreased | 38.36 | 25.61 | 3 | 61224 | 24346 | 29866905 |
| Flushing | 38.24 | 25.61 | 7 | 61220 | 29485 | 29861766 |
| Aspartate aminotransferase increased | 38.16 | 25.61 | 44 | 61183 | 63378 | 29827873 |
| Brain stem infarction | 38.15 | 25.61 | 27 | 61200 | 1279 | 29889972 |
| Carotid artery disease | 38.04 | 25.61 | 24 | 61203 | 937 | 29890314 |
| Anaphylactic reaction | 37.69 | 25.61 | 6 | 61221 | 27976 | 29863275 |
| Haemoptysis | 36.96 | 25.61 | 9 | 61218 | 31069 | 29860182 |
| Depressed level of consciousness | 36.79 | 25.61 | 16 | 61211 | 38206 | 29853045 |
| Therapy non-responder | 36.08 | 25.61 | 8 | 61219 | 29445 | 29861806 |
| Cerebellar infarction | 35.93 | 25.61 | 30 | 61197 | 1819 | 29889432 |
| Hepatocellular injury | 35.37 | 25.61 | 5 | 61222 | 25466 | 29865785 |
| Multiple organ dysfunction syndrome | 35.10 | 25.61 | 47 | 61180 | 63440 | 29827811 |
| Restlessness | 35.01 | 25.61 | 3 | 61224 | 22596 | 29868655 |
| Wheezing | 34.82 | 25.61 | 10 | 61217 | 30928 | 29860323 |
| Aggression | 34.66 | 25.61 | 16 | 61211 | 36891 | 29854360 |
| Cholestasis | 34.41 | 25.61 | 5 | 61222 | 24945 | 29866306 |
| Incorrect dose administered | 34.29 | 25.61 | 11 | 61216 | 31675 | 29859576 |
| Aortic valve replacement | 34.10 | 25.61 | 20 | 61207 | 683 | 29890568 |
| Cardiopulmonary failure | 34.03 | 25.61 | 41 | 61186 | 3870 | 29887381 |
| Metabolic acidosis | 34.02 | 25.61 | 17 | 61210 | 37444 | 29853807 |
| Disorientation | 33.84 | 25.61 | 11 | 61216 | 31407 | 29859844 |
| Gastrointestinal disorder | 33.76 | 25.61 | 8 | 61219 | 28129 | 29863122 |
| Hypoxia | 33.60 | 25.61 | 29 | 61198 | 47825 | 29843426 |
| Adverse drug reaction | 33.45 | 25.61 | 4 | 61223 | 23141 | 29868110 |
| Influenza like illness | 33.36 | 25.61 | 6 | 61221 | 25599 | 29865652 |
| Cellulitis | 33.28 | 25.61 | 28 | 61199 | 46756 | 29844495 |
| Productive cough | 33.13 | 25.61 | 10 | 61217 | 29943 | 29861308 |
| Death | 33.05 | 25.61 | 523 | 60704 | 356760 | 29534491 |
| Rash maculo-papular | 33.02 | 25.61 | 6 | 61221 | 25412 | 29865839 |
| Haematuria | 32.93 | 25.61 | 26 | 61201 | 44808 | 29846443 |
| Leukocytosis | 32.91 | 25.61 | 3 | 61224 | 21499 | 29869752 |
| Peritonitis | 32.67 | 25.61 | 3 | 61224 | 21372 | 29869879 |
| Brain stem stroke | 32.55 | 25.61 | 12 | 61215 | 135 | 29891116 |
| Rash erythematous | 32.15 | 25.61 | 4 | 61223 | 22448 | 29868803 |
| Melaena | 32.15 | 25.61 | 13 | 61214 | 32424 | 29858827 |
| Left ventricular dysfunction | 32.03 | 25.61 | 61 | 61166 | 8630 | 29882621 |
| Syncope | 31.67 | 25.61 | 80 | 61147 | 84823 | 29806428 |
| Rectal haemorrhage | 31.51 | 25.61 | 16 | 61211 | 34923 | 29856328 |
| Lower respiratory tract infection | 31.26 | 25.61 | 8 | 61219 | 26706 | 29864545 |
| Memory impairment | 30.68 | 25.61 | 19 | 61208 | 37155 | 29854096 |
| Sinusitis | 30.48 | 25.61 | 15 | 61212 | 33330 | 29857921 |
| Hypertensive cardiomyopathy | 30.45 | 25.61 | 12 | 61215 | 164 | 29891087 |
| Haematochezia | 30.37 | 25.61 | 16 | 61211 | 34206 | 29857045 |
| Therapeutic product effect decreased | 29.90 | 25.61 | 11 | 61216 | 29065 | 29862186 |
| Transaminases increased | 29.49 | 25.61 | 6 | 61221 | 23451 | 29867800 |
| Deep vein thrombosis | 29.35 | 25.61 | 49 | 61178 | 60452 | 29830799 |
| Disseminated intravascular coagulation | 29.31 | 25.61 | 5 | 61222 | 22166 | 29869085 |
| Eosinophilia | 29.29 | 25.61 | 5 | 61222 | 22155 | 29869096 |
| Rhinorrhoea | 28.99 | 25.61 | 4 | 61223 | 20750 | 29870501 |
| Dyskinesia | 28.70 | 25.61 | 5 | 61222 | 21829 | 29869422 |
| Bronchitis | 28.34 | 25.61 | 23 | 61204 | 39102 | 29852149 |
| Heart rate irregular | 28.02 | 25.61 | 71 | 61156 | 12188 | 29879063 |
| Blood creatine phosphokinase increased | 27.94 | 25.61 | 29 | 61198 | 43819 | 29847432 |
| Swelling face | 27.56 | 25.61 | 5 | 61222 | 21199 | 29870052 |
| Acute respiratory distress syndrome | 27.52 | 25.61 | 7 | 61220 | 23465 | 29867786 |
| Altered state of consciousness | 27.45 | 25.61 | 4 | 61223 | 19915 | 29871336 |
| Osteonecrosis of jaw | 27.45 | 25.61 | 3 | 61224 | 18615 | 29872636 |
| Ascites | 27.44 | 25.61 | 20 | 61207 | 35901 | 29855350 |
| Skin lesion | 27.21 | 25.61 | 3 | 61224 | 18491 | 29872760 |
| Contusion | 27.21 | 25.61 | 15 | 61212 | 31265 | 29859986 |
| Disturbance in attention | 27.13 | 25.61 | 6 | 61221 | 22123 | 29869128 |
| Coronary artery insufficiency | 27.08 | 25.61 | 10 | 61217 | 113 | 29891138 |
| Staphylococcal infection | 27.02 | 25.61 | 14 | 61213 | 30210 | 29861041 |
| Inflammation | 26.94 | 25.61 | 6 | 61221 | 22020 | 29869231 |
| Nephrolithiasis | 26.17 | 25.61 | 9 | 61218 | 24801 | 29866450 |
| Gait disturbance | 25.96 | 25.61 | 73 | 61154 | 74704 | 29816547 |
| Aortic valve stenosis | 25.87 | 25.61 | 24 | 61203 | 1675 | 29889576 |
| Abnormal behaviour | 25.83 | 25.61 | 10 | 61217 | 25613 | 29865638 |
| Hypocalcaemia | 25.79 | 25.61 | 6 | 61221 | 21370 | 29869881 |
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | A10BD03 | ALIMENTARY TRACT AND METABOLISM DRUGS USED IN DIABETES BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS Combinations of oral blood glucose lowering drugs |
| ATC | A10BD04 | ALIMENTARY TRACT AND METABOLISM DRUGS USED IN DIABETES BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS Combinations of oral blood glucose lowering drugs |
| ATC | A10BG02 | ALIMENTARY TRACT AND METABOLISM DRUGS USED IN DIABETES BLOOD GLUCOSE LOWERING DRUGS, EXCL. INSULINS Thiazolidinediones |
| FDA CS | M0199114 | PPAR gamma |
| FDA CS | M0447306 | Thiazolidinediones |
| FDA MoA | N0000175374 | Peroxisome Proliferator-activated Receptor Activity |
| FDA EPC | N0000180186 | Peroxisome Proliferator Receptor gamma Agonist |
| FDA EPC | N0000180190 | Thiazolidinedione |
| MeSH PA | D007004 | Hypoglycemic Agents |
| CHEBI has role | CHEBI:50864 | glitazone drug |
Drug Use (View source of the data)
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Treatment Refractory Type 2 Diabetes Mellitus | indication | ||
| Alcoholism | contraindication | 7200002 | |
| Weight gain finding | contraindication | 8943002 | |
| Asthenia | contraindication | 13791008 | |
| Pulmonary edema | contraindication | 19242006 | DOID:11396 |
| Myocardial infarction | contraindication | 22298006 | DOID:5844 |
| Acute vomiting | contraindication | 23971007 | |
| Alcohol intoxication | contraindication | 25702006 | |
| Shock | contraindication | 27942005 | |
| Dehydration | contraindication | 34095006 | |
| Macular retinal edema | contraindication | 37231002 | DOID:4449 |
| Infectious disease | contraindication | 40733004 | |
| Body fluid retention | contraindication | 43498006 | |
| Chronic heart failure | contraindication | 48447003 | |
| Hepatic porphyria | contraindication | 55056006 | DOID:3133 |
| Ketoacidosis | contraindication | 56051008 | |
| Metabolic acidosis | contraindication | 59455009 | |
| Hemolytic anemia | contraindication | 61261009 | DOID:583 |
| Glucose-6-phosphate dehydrogenase deficiency anemia | contraindication | 62403005 | |
| Osteoporosis | contraindication | 64859006 | DOID:11476 |
| Hypopituitarism | contraindication | 74728003 | DOID:9406 |
| Cardiogenic shock | contraindication | 89138009 | |
| Kidney disease | contraindication | 90708001 | DOID:557 |
| Lactic acidosis | contraindication | 91273001 | DOID:3650 |
| Fracture of bone | contraindication | 125605004 | |
| Autonomic dysreflexia | contraindication | 129618003 | |
| Liver function tests abnormal | contraindication | 166603001 | |
| Cobalamin deficiency | contraindication | 190634004 | |
| Angina pectoris | contraindication | 194828000 | |
| Decompensated cardiac failure | contraindication | 195111005 | |
| Cerebrovascular accident | contraindication | 230690007 | |
| Disease of liver | contraindication | 235856003 | DOID:409 |
| Drug-induced hepatitis | contraindication | 235876009 | |
| Hypoglycemic disorder | contraindication | 237630007 | |
| Sepsis syndrome | contraindication | 238150007 | |
| Osteopenia | contraindication | 312894000 | |
| Primary adrenocortical insufficiency | contraindication | 373662000 | |
| Adrenal cortical hypofunction | contraindication | 386584007 | DOID:10493 |
| Fever | contraindication | 386661006 | |
| Surgical procedure | contraindication | 387713003 | |
| Severe diarrhea | contraindication | 409587002 | |
| Breastfeeding (mother) | contraindication | 413712001 | |
| Disorder of coronary artery | contraindication | 414024009 | |
| Myocardial ischemia | contraindication | 414795007 | DOID:3393 |
| Traumatic injury | contraindication | 417746004 | |
| Fever greater than 100.4 Fahrenheit | contraindication | 426000000 | |
| Radiography with IV Iodinated Contrast Agent | contraindication | ||
| Severe Hypoxemia | contraindication |
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 6.5 | acidic |
| pKa2 | 5.84 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Peroxisome proliferator-activated receptor gamma | Nuclear hormone receptor | AGONIST | EC50 | 7.04 | WOMBAT-PK | CHEMBL | |||
| Free fatty acid receptor 1 | GPCR | AGONIST | EC50 | 5.60 | IUPHAR | ||||
| Carbonic anhydrase 2 | Enzyme | IC50 | 5.39 | DRUG MATRIX | |||||
| Thromboxane-A synthase | Enzyme | IC50 | 5.45 | DRUG MATRIX | |||||
| Amine oxidase [flavin-containing] B | Enzyme | Ki | 5.38 | CHEMBL | |||||
| Amine oxidase [flavin-containing] A | Enzyme | Ki | 4.56 | CHEMBL | |||||
| Peroxisome proliferator-activated receptor delta | Nuclear hormone receptor | EC50 | 5.44 | CHEMBL | |||||
| Peroxisome proliferator-activated receptor alpha | Nuclear hormone receptor | EC50 | 7.41 | CHEMBL | |||||
| Retinoic acid receptor gamma | Nuclear hormone receptor | Ki | 5 | CHEMBL | |||||
| Short transient receptor potential channel 5 | Ion channel | ACTIVATOR | EC50 | 4.51 | IUPHAR | ||||
| Bile salt export pump | Transporter | IC50 | 5.19 | CHEMBL | |||||
| Type-1A angiotensin II receptor | GPCR | Ki | 9.64 | CHEMBL | |||||
| Amine oxidase [flavin-containing] B | Enzyme | Ki | 5.24 | CHEMBL | |||||
| Amine oxidase [flavin-containing] A | Enzyme | Ki | 4.49 | CHEMBL | |||||
| Bile salt export pump | Unclassified | IC50 | 4.40 | CHEMBL | |||||
| Peroxisome proliferator-activated receptor gamma | Transcription factor | EC50 | 7.52 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4021162 | VUID |
| N0000148613 | NUI |
| D00596 | KEGG_DRUG |
| 302543-62-0 | SECONDARY_CAS_RN |
| 4021162 | VANDF |
| 4021163 | VANDF |
| C0289313 | UMLSCUI |
| CHEBI:50122 | CHEBI |
| BRL | PDB_CHEM_ID |
| CHEMBL121 | ChEMBL_ID |
| CHEMBL843 | ChEMBL_ID |
| D000077154 | MESH_DESCRIPTOR_UI |
| 1056 | IUPHAR_LIGAND_ID |
| 7662 | INN_ID |
| DB00412 | DRUGBANK_ID |
| 05V02F2KDG | UNII |
| 77999 | PUBCHEM_CID |
| 253198 | RXNORM |
| 8221 | MMSL |
| d04434 | MMSL |
| 007789 | NDDF |
| 007790 | NDDF |
| 116096001 | SNOMEDCT_US |
| 326053005 | SNOMEDCT_US |
| 395869000 | SNOMEDCT_US |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| AVANDIA2MG | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0173-0861 | TABLET, FILM COATED | 2 mg | ORAL | NDA | 29 sections |
| AVANDIA4MG | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0173-0863 | TABLET, FILM COATED | 4 mg | ORAL | NDA | 29 sections |
| Avandia | HUMAN PRESCRIPTION DRUG LABEL | 1 | 54868-4198 | TABLET, FILM COATED | 4 mg | ORAL | NDA | 19 sections |
| Avandia | HUMAN PRESCRIPTION DRUG LABEL | 1 | 54868-4221 | TABLET, FILM COATED | 8 mg | ORAL | NDA | 19 sections |
| AVANDAMET | HUMAN PRESCRIPTION DRUG LABEL | 2 | 54868-4965 | TABLET, FILM COATED | 2 mg | ORAL | NDA | 30 sections |
| AVANDAMET | HUMAN PRESCRIPTION DRUG LABEL | 2 | 54868-5157 | TABLET, FILM COATED | 4 mg | ORAL | NDA | 30 sections |
| Avandia | HUMAN PRESCRIPTION DRUG LABEL | 1 | 54868-5249 | TABLET, FILM COATED | 2 mg | ORAL | NDA | 19 sections |
| AVANDAMET | HUMAN PRESCRIPTION DRUG LABEL | 2 | 54868-5262 | TABLET, FILM COATED | 4 mg | ORAL | NDA | 30 sections |
| AVANDAMET | HUMAN PRESCRIPTION DRUG LABEL | 2 | 54868-5376 | TABLET, FILM COATED | 2 mg | ORAL | NDA | 30 sections |