Stem definition | Drug id | CAS RN |
---|---|---|
463 | 58-08-2 |
Dose | Unit | Route |
---|---|---|
0.40 | g | O |
0.40 | g | P |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 21.50 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 1 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 51.77 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 98 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 0.63 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 1.40 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.64 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 4.90 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Nov. 26, 1948 | FDA | NOVARTIS |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Completed suicide | 2535.06 | 9.89 | 3633 | 362838 | 142040 | 62980511 |
Toxicity to various agents | 2037.71 | 9.89 | 4439 | 362032 | 242811 | 62879740 |
Infusion related reaction | 718.61 | 9.89 | 3063 | 363408 | 242458 | 62880093 |
Sinusitis | 527.69 | 9.89 | 2645 | 363826 | 224008 | 62898543 |
Acute hepatic failure | 484.33 | 9.89 | 563 | 365908 | 17764 | 63104787 |
Muscle injury | 476.89 | 9.89 | 1120 | 365351 | 64225 | 63058326 |
Overdose | 474.65 | 9.89 | 1603 | 364868 | 113475 | 63009076 |
Folliculitis | 473.23 | 9.89 | 1168 | 365303 | 69149 | 63053402 |
Lower respiratory tract infection | 450.42 | 9.89 | 1731 | 364740 | 130576 | 62991975 |
Exposure to toxic agent | 437.55 | 9.89 | 316 | 366155 | 5271 | 63117280 |
Irritable bowel syndrome | 427.40 | 9.89 | 1243 | 365228 | 81169 | 63041382 |
Product dose omission issue | 394.26 | 9.89 | 463 | 366008 | 233850 | 62888701 |
Blister | 370.94 | 9.89 | 1609 | 364862 | 128205 | 62994346 |
Metabolic acidosis | 348.05 | 9.89 | 790 | 365681 | 44279 | 63078272 |
Ill-defined disorder | 318.77 | 9.89 | 1118 | 365353 | 80637 | 63041914 |
Rheumatoid arthritis | 310.60 | 9.89 | 2515 | 363956 | 251304 | 62871247 |
Impaired healing | 303.67 | 9.89 | 1285 | 365186 | 101257 | 63021294 |
Intentional product misuse | 296.00 | 9.89 | 898 | 365573 | 60019 | 63062532 |
Sleep disorder due to general medical condition, insomnia type | 292.51 | 9.89 | 810 | 365661 | 51407 | 63071144 |
Duodenal ulcer perforation | 291.72 | 9.89 | 1135 | 365336 | 86074 | 63036477 |
Helicobacter infection | 284.31 | 9.89 | 1175 | 365296 | 91610 | 63030941 |
Blood pressure fluctuation | 282.06 | 9.89 | 741 | 365730 | 45576 | 63076975 |
Injection site pain | 269.98 | 9.89 | 212 | 366259 | 129588 | 62992963 |
Anti-cyclic citrullinated peptide antibody positive | 269.83 | 9.89 | 1356 | 365115 | 114856 | 63007695 |
Hepatic enzyme increased | 250.72 | 9.89 | 2011 | 364460 | 200317 | 62922234 |
Joint swelling | 247.97 | 9.89 | 2936 | 363535 | 324730 | 62797821 |
Pericarditis | 244.57 | 9.89 | 1445 | 365026 | 130134 | 62992417 |
Nasopharyngitis | 225.00 | 9.89 | 2350 | 364121 | 251907 | 62870644 |
Therapeutic product effect decreased | 220.50 | 9.89 | 1885 | 364586 | 191302 | 62931249 |
Anion gap | 207.74 | 9.89 | 116 | 366355 | 1201 | 63121350 |
Gastrointestinal disorder | 202.15 | 9.89 | 1374 | 365097 | 129865 | 62992686 |
Stomatitis | 192.45 | 9.89 | 1416 | 365055 | 137309 | 62985242 |
Body temperature increased | 184.15 | 9.89 | 552 | 365919 | 36640 | 63085911 |
Diarrhoea | 178.41 | 9.89 | 2982 | 363489 | 712384 | 62410167 |
Psoriasis | 177.06 | 9.89 | 145 | 366326 | 86812 | 63035739 |
Hepatotoxicity | 169.65 | 9.89 | 535 | 365936 | 36506 | 63086045 |
Intentional overdose | 166.96 | 9.89 | 858 | 365613 | 73294 | 63049257 |
Device expulsion | 161.59 | 9.89 | 10 | 366461 | 34912 | 63087639 |
Swelling | 157.16 | 9.89 | 2345 | 364126 | 273033 | 62849518 |
Hypersensitivity | 156.91 | 9.89 | 2466 | 364005 | 290219 | 62832332 |
Depressed level of consciousness | 153.01 | 9.89 | 737 | 365734 | 61341 | 63061210 |
Respiratory arrest | 151.79 | 9.89 | 474 | 365997 | 32171 | 63090380 |
Weight increased | 150.83 | 9.89 | 2226 | 364245 | 258566 | 62863985 |
Discomfort | 150.26 | 9.89 | 1552 | 364919 | 165822 | 62956729 |
Synovitis | 146.05 | 9.89 | 1686 | 364785 | 185232 | 62937319 |
Hand deformity | 142.85 | 9.89 | 1478 | 364993 | 157979 | 62964572 |
Medication error | 141.55 | 9.89 | 638 | 365833 | 51646 | 63070905 |
Intentional product use issue | 138.04 | 9.89 | 1233 | 365238 | 126659 | 62995892 |
Coagulopathy | 134.68 | 9.89 | 338 | 366133 | 20206 | 63102345 |
Ear pain | 133.07 | 9.89 | 485 | 365986 | 35633 | 63086918 |
Injection site erythema | 132.70 | 9.89 | 171 | 366300 | 83003 | 63039548 |
Confusional state | 132.12 | 9.89 | 2006 | 364465 | 234374 | 62888177 |
Peripheral swelling | 129.23 | 9.89 | 2205 | 364266 | 263737 | 62858814 |
Wrong technique in product usage process | 128.08 | 9.89 | 103 | 366368 | 62237 | 63060314 |
Cardio-respiratory arrest | 126.18 | 9.89 | 681 | 365790 | 59278 | 63063273 |
Disease progression | 125.08 | 9.89 | 332 | 366139 | 122426 | 63000125 |
Wound | 125.00 | 9.89 | 1467 | 365004 | 161796 | 62960755 |
Rheumatoid factor positive | 123 | 9.89 | 872 | 365599 | 83534 | 63039017 |
Hepatic failure | 119.10 | 9.89 | 464 | 366007 | 35192 | 63087359 |
Injection site reaction | 118.61 | 9.89 | 98 | 366373 | 58426 | 63064125 |
Anaemia | 106.43 | 9.89 | 1131 | 365340 | 292299 | 62830252 |
Off label use | 105.44 | 9.89 | 3027 | 363444 | 671435 | 62451116 |
COVID-19 | 104.83 | 9.89 | 320 | 366151 | 112783 | 63009768 |
Drug ineffective | 104.59 | 9.89 | 4951 | 361520 | 1039814 | 62082737 |
Poisoning | 102.25 | 9.89 | 237 | 366234 | 13463 | 63109088 |
Heart rate decreased | 101.02 | 9.89 | 525 | 365946 | 45035 | 63077516 |
Neutropenia | 100.46 | 9.89 | 595 | 365876 | 174410 | 62948141 |
Muscle spasticity | 99.07 | 9.89 | 314 | 366157 | 21480 | 63101071 |
Analgesic drug level increased | 98.87 | 9.89 | 93 | 366378 | 2279 | 63120272 |
Infection | 98.84 | 9.89 | 1865 | 364606 | 227308 | 62895243 |
Therapeutic product effect incomplete | 98.83 | 9.89 | 379 | 366092 | 124677 | 62997874 |
Creatinine renal clearance decreased | 94.29 | 9.89 | 256 | 366215 | 16052 | 63106499 |
Hospitalisation | 93.74 | 9.89 | 221 | 366250 | 84860 | 63037691 |
Injection site pruritus | 93.36 | 9.89 | 74 | 366397 | 45042 | 63077509 |
Sedation complication | 93.33 | 9.89 | 230 | 366241 | 13592 | 63108959 |
Night sweats | 92.47 | 9.89 | 539 | 365932 | 48275 | 63074276 |
Hepatic necrosis | 90.15 | 9.89 | 136 | 366335 | 5551 | 63117000 |
Injection site bruising | 87.66 | 9.89 | 68 | 366403 | 41842 | 63080709 |
Acute lung injury | 86.25 | 9.89 | 72 | 366399 | 1499 | 63121052 |
Sopor | 85.23 | 9.89 | 13 | 366458 | 22151 | 63100400 |
Drug resistance | 84.73 | 9.89 | 15 | 366456 | 22918 | 63099633 |
Neuropathy peripheral | 82.58 | 9.89 | 356 | 366115 | 113311 | 63009240 |
Therapy cessation | 81.17 | 9.89 | 37 | 366434 | 30420 | 63092131 |
Respiratory depression | 81.01 | 9.89 | 217 | 366254 | 13498 | 63109053 |
Blood calcium decreased | 80.96 | 9.89 | 335 | 366136 | 26116 | 63096435 |
Cardiac failure congestive | 79.74 | 9.89 | 270 | 366201 | 92163 | 63030388 |
Infusion site pain | 78.47 | 9.89 | 245 | 366226 | 16624 | 63105927 |
Drug hypersensitivity | 77.73 | 9.89 | 1293 | 365178 | 309394 | 62813157 |
Infusion site swelling | 76.21 | 9.89 | 172 | 366299 | 9598 | 63112953 |
Malignant neoplasm progression | 75.62 | 9.89 | 233 | 366238 | 81888 | 63040663 |
Rheumatic fever | 75.26 | 9.89 | 466 | 366005 | 42645 | 63079906 |
Exposure via ingestion | 74.57 | 9.89 | 88 | 366383 | 2821 | 63119730 |
Pruritus | 73.18 | 9.89 | 2661 | 363810 | 358792 | 62763759 |
Therapy interrupted | 72.65 | 9.89 | 49 | 366422 | 32406 | 63090145 |
Injection site swelling | 72.62 | 9.89 | 101 | 366370 | 47471 | 63075080 |
Pyroglutamate increased | 69.99 | 9.89 | 39 | 366432 | 402 | 63122149 |
Myocardial infarction | 69.45 | 9.89 | 318 | 366153 | 99575 | 63022976 |
Myelosuppression | 69.34 | 9.89 | 25 | 366446 | 23678 | 63098873 |
No adverse event | 69.31 | 9.89 | 82 | 366389 | 41323 | 63081228 |
Cognitive disorder | 69.10 | 9.89 | 555 | 365916 | 55260 | 63067291 |
Drug ineffective for unapproved indication | 69.07 | 9.89 | 57 | 366414 | 34006 | 63088545 |
Osteonecrosis of jaw | 68.50 | 9.89 | 61 | 366410 | 35062 | 63087489 |
Suspected suicide | 68.12 | 9.89 | 130 | 366341 | 6438 | 63116113 |
Cardiac failure | 67.96 | 9.89 | 274 | 366197 | 88868 | 63033683 |
Glossodynia | 67.15 | 9.89 | 1426 | 365045 | 177450 | 62945101 |
Oxygen saturation decreased | 66.85 | 9.89 | 794 | 365677 | 87791 | 63034760 |
Respiratory disorder | 64.22 | 9.89 | 416 | 366055 | 38666 | 63083885 |
Coma | 64.07 | 9.89 | 610 | 365861 | 63754 | 63058797 |
Nausea | 63.84 | 9.89 | 4165 | 362306 | 850306 | 62272245 |
Blood pressure diastolic abnormal | 63.80 | 9.89 | 207 | 366264 | 14335 | 63108216 |
Feeling abnormal | 61.71 | 9.89 | 553 | 365918 | 147839 | 62974712 |
Blood cholesterol increased | 61.64 | 9.89 | 821 | 365650 | 93211 | 63029340 |
Orthostatic hypotension | 60.09 | 9.89 | 386 | 366085 | 35774 | 63086777 |
Swollen joint count increased | 60.00 | 9.89 | 385 | 366086 | 35669 | 63086882 |
Blood pressure increased | 59.87 | 9.89 | 1289 | 365182 | 160773 | 62961778 |
Blood pressure diastolic decreased | 58.42 | 9.89 | 273 | 366198 | 22433 | 63100118 |
Contusion | 57.22 | 9.89 | 1199 | 365272 | 148845 | 62973706 |
Product storage error | 56.99 | 9.89 | 9 | 366462 | 14947 | 63107604 |
Hepatic cytolysis | 56.83 | 9.89 | 207 | 366264 | 15200 | 63107351 |
Pemphigus | 56.38 | 9.89 | 1424 | 365047 | 182302 | 62940249 |
Interstitial lung disease | 56.04 | 9.89 | 177 | 366294 | 61731 | 63060820 |
Surgery | 55.06 | 9.89 | 76 | 366395 | 35836 | 63086715 |
Product quality issue | 54.89 | 9.89 | 76 | 366395 | 35789 | 63086762 |
Arthropathy | 54.88 | 9.89 | 1758 | 364713 | 233034 | 62889517 |
Infusion site erythema | 54.67 | 9.89 | 170 | 366301 | 11509 | 63111042 |
White blood cell count decreased | 54.56 | 9.89 | 526 | 365945 | 138578 | 62983973 |
Neoplasm progression | 52.98 | 9.89 | 80 | 366391 | 36348 | 63086203 |
International normalised ratio increased | 52.85 | 9.89 | 453 | 366018 | 45972 | 63076579 |
Red blood cell sedimentation rate abnormal | 52.76 | 9.89 | 24 | 366447 | 19758 | 63102793 |
Dizziness | 52.38 | 9.89 | 1991 | 364480 | 427934 | 62694617 |
Cerebrovascular accident | 52.02 | 9.89 | 387 | 366084 | 107637 | 63014914 |
Mucosal inflammation | 51.60 | 9.89 | 122 | 366349 | 46806 | 63075745 |
Contraindicated product administered | 50.96 | 9.89 | 1630 | 364841 | 216018 | 62906533 |
Infusion site extravasation | 50.89 | 9.89 | 154 | 366317 | 10272 | 63112279 |
Throat irritation | 50.27 | 9.89 | 381 | 366090 | 37266 | 63085285 |
Electric shock | 49.82 | 9.89 | 49 | 366422 | 1271 | 63121280 |
Pancytopenia | 49.72 | 9.89 | 341 | 366130 | 96592 | 63025959 |
Sedation | 49.18 | 9.89 | 388 | 366083 | 38421 | 63084130 |
Urticaria | 49.08 | 9.89 | 1279 | 365192 | 164523 | 62958028 |
Product substitution issue | 48.30 | 9.89 | 16 | 366455 | 15980 | 63106571 |
Rash pruritic | 48.01 | 9.89 | 180 | 366291 | 59619 | 63062932 |
Product prescribing error | 47.37 | 9.89 | 49 | 366422 | 26240 | 63096311 |
Device dislocation | 47.36 | 9.89 | 47 | 366424 | 25658 | 63096893 |
Palmar-plantar erythrodysaesthesia syndrome | 47.30 | 9.89 | 38 | 366433 | 22977 | 63099574 |
Cardiac arrest | 47.29 | 9.89 | 774 | 365697 | 91771 | 63030780 |
Device malfunction | 47.11 | 9.89 | 22 | 366449 | 17835 | 63104716 |
Injection site rash | 46.87 | 9.89 | 25 | 366446 | 18784 | 63103767 |
Dyspnoea exertional | 46.82 | 9.89 | 184 | 366287 | 60118 | 63062433 |
Mobility decreased | 46.78 | 9.89 | 970 | 365501 | 120189 | 63002362 |
Hypotension | 46.43 | 9.89 | 1970 | 364501 | 270634 | 62851917 |
Posterior reversible encephalopathy syndrome | 46.33 | 9.89 | 21 | 366450 | 17324 | 63105227 |
Liver injury | 45.89 | 9.89 | 543 | 365928 | 59977 | 63062574 |
Crystal urine present | 45.69 | 9.89 | 52 | 366419 | 1602 | 63120949 |
Anion gap abnormal | 45.65 | 9.89 | 29 | 366442 | 387 | 63122164 |
Epistaxis | 45.64 | 9.89 | 240 | 366231 | 72485 | 63050066 |
Pyroglutamic acidosis | 45.40 | 9.89 | 34 | 366437 | 601 | 63121950 |
Pyrexia | 45.38 | 9.89 | 3225 | 363246 | 467253 | 62655298 |
Bone marrow failure | 44.89 | 9.89 | 62 | 366409 | 29228 | 63093323 |
Arthralgia | 44.75 | 9.89 | 3843 | 362628 | 565867 | 62556684 |
Renal impairment | 44.74 | 9.89 | 312 | 366159 | 88043 | 63034508 |
Blood parathyroid hormone decreased | 44.71 | 9.89 | 3 | 366468 | 9788 | 63112763 |
Injury | 44.52 | 9.89 | 631 | 365840 | 72616 | 63049935 |
Injection site warmth | 44.49 | 9.89 | 16 | 366455 | 15179 | 63107372 |
Drug interaction | 44.27 | 9.89 | 996 | 365475 | 228135 | 62894416 |
Soft tissue disorder | 43.99 | 9.89 | 86 | 366385 | 4336 | 63118215 |
Dry skin | 43.89 | 9.89 | 174 | 366297 | 56713 | 63065838 |
White blood cells urine positive | 43.85 | 9.89 | 94 | 366377 | 5064 | 63117487 |
Gastrooesophageal reflux disease | 43.53 | 9.89 | 348 | 366123 | 95291 | 63027260 |
Heart rate irregular | 43.38 | 9.89 | 249 | 366222 | 22172 | 63100379 |
Device issue | 43.22 | 9.89 | 44 | 366427 | 23737 | 63098814 |
Unevaluable event | 43.02 | 9.89 | 152 | 366319 | 51234 | 63071317 |
Impaired quality of life | 43.01 | 9.89 | 13 | 366458 | 13770 | 63108781 |
Paraesthesia | 42.97 | 9.89 | 642 | 365829 | 156324 | 62966227 |
Full blood count abnormal | 42.06 | 9.89 | 74 | 366397 | 31643 | 63090908 |
Device difficult to use | 41.92 | 9.89 | 11 | 366460 | 12785 | 63109766 |
Diabetes mellitus | 41.62 | 9.89 | 173 | 366298 | 55637 | 63066914 |
Blood pressure systolic abnormal | 40.54 | 9.89 | 169 | 366302 | 13217 | 63109334 |
Heart rate increased | 40.23 | 9.89 | 766 | 365705 | 93472 | 63029079 |
Blood pressure systolic increased | 39.88 | 9.89 | 434 | 366037 | 46963 | 63075588 |
Injection site mass | 39.35 | 9.89 | 30 | 366441 | 18626 | 63103925 |
Rash | 39.10 | 9.89 | 3751 | 362720 | 557120 | 62565431 |
Urine abnormality | 38.41 | 9.89 | 108 | 366363 | 6911 | 63115640 |
Malaise | 38.36 | 9.89 | 1986 | 364485 | 413968 | 62708583 |
Accidental overdose | 38.22 | 9.89 | 248 | 366223 | 23061 | 63099490 |
Suicide attempt | 37.91 | 9.89 | 527 | 365944 | 60391 | 63062160 |
Injection site haemorrhage | 37.73 | 9.89 | 51 | 366420 | 24263 | 63098288 |
Drug abuse | 37.60 | 9.89 | 608 | 365863 | 71910 | 63050641 |
Body temperature decreased | 37.59 | 9.89 | 223 | 366248 | 20096 | 63102455 |
Infusion site pruritus | 37.18 | 9.89 | 97 | 366374 | 5938 | 63116613 |
Lymphocyte count decreased | 36.97 | 9.89 | 300 | 366171 | 29957 | 63092594 |
Substance abuse | 36.80 | 9.89 | 84 | 366387 | 4723 | 63117828 |
Muscle spasms | 36.68 | 9.89 | 657 | 365814 | 155493 | 62967058 |
Product use in unapproved indication | 36.43 | 9.89 | 772 | 365699 | 178308 | 62944243 |
Pneumonia | 36.43 | 9.89 | 2212 | 364259 | 454555 | 62667996 |
Alanine aminotransferase increased | 36.28 | 9.89 | 819 | 365652 | 102951 | 63019600 |
Injection site urticaria | 36.11 | 9.89 | 18 | 366453 | 14055 | 63108496 |
Disease recurrence | 35.74 | 9.89 | 67 | 366404 | 27963 | 63094588 |
Full blood count decreased | 35.16 | 9.89 | 60 | 366411 | 25964 | 63096587 |
Bone pain | 35.03 | 9.89 | 179 | 366292 | 54462 | 63068089 |
Decreased appetite | 34.78 | 9.89 | 1144 | 365327 | 249908 | 62872643 |
Fall | 34.52 | 9.89 | 1882 | 364589 | 390452 | 62732099 |
Respiratory rate increased | 34.31 | 9.89 | 163 | 366308 | 13485 | 63109066 |
Blood pH decreased | 34.29 | 9.89 | 57 | 366414 | 2530 | 63120021 |
Administration site swelling | 34.27 | 9.89 | 40 | 366431 | 1267 | 63121284 |
Dysgeusia | 34.08 | 9.89 | 146 | 366325 | 46564 | 63075987 |
Urinary sediment present | 33.95 | 9.89 | 52 | 366419 | 2151 | 63120400 |
Thrombocytopenia | 33.93 | 9.89 | 641 | 365830 | 150516 | 62972035 |
Acute kidney injury | 33.56 | 9.89 | 1213 | 365258 | 262202 | 62860349 |
Bursitis | 33.43 | 9.89 | 344 | 366127 | 36697 | 63085854 |
Systemic lupus erythematosus | 33.37 | 9.89 | 1500 | 364971 | 207418 | 62915133 |
Underdose | 32.96 | 9.89 | 68 | 366403 | 27388 | 63095163 |
Administration site pain | 32.79 | 9.89 | 32 | 366439 | 822 | 63121729 |
Myelodysplastic syndrome | 32.79 | 9.89 | 29 | 366442 | 16725 | 63105826 |
Dermatitis atopic | 32.55 | 9.89 | 8 | 366463 | 9716 | 63112835 |
Hyperkalaemia | 32.29 | 9.89 | 182 | 366289 | 54021 | 63068530 |
Drug intolerance | 32.20 | 9.89 | 2130 | 364341 | 306531 | 62816020 |
Memory impairment | 31.51 | 9.89 | 418 | 366053 | 103840 | 63018711 |
Neutrophil percentage increased | 31.45 | 9.89 | 59 | 366412 | 2884 | 63119667 |
Red blood cells urine positive | 31.35 | 9.89 | 61 | 366410 | 3065 | 63119486 |
Illness | 31.29 | 9.89 | 161 | 366310 | 48898 | 63073653 |
Oedema peripheral | 30.57 | 9.89 | 846 | 365625 | 188665 | 62933886 |
Fibromyalgia | 30.43 | 9.89 | 642 | 365829 | 79778 | 63042773 |
Musculoskeletal disorder | 30.35 | 9.89 | 45 | 366426 | 20599 | 63101952 |
Rhinitis allergic | 30.09 | 9.89 | 15 | 366456 | 11712 | 63110839 |
Abortion spontaneous | 30.03 | 9.89 | 155 | 366316 | 47040 | 63075511 |
Myalgia | 29.99 | 9.89 | 631 | 365840 | 145898 | 62976653 |
Angioedema | 29.70 | 9.89 | 159 | 366312 | 47806 | 63074745 |
Lymphocyte percentage decreased | 29.63 | 9.89 | 58 | 366413 | 2927 | 63119624 |
Burning sensation | 29.61 | 9.89 | 188 | 366283 | 54219 | 63068332 |
Acidosis | 29.59 | 9.89 | 136 | 366335 | 11097 | 63111454 |
Hypercalcaemia | 29.28 | 9.89 | 76 | 366395 | 28246 | 63094305 |
Accidental exposure to product | 28.75 | 9.89 | 73 | 366398 | 27332 | 63095219 |
Infusion site nodule | 28.52 | 9.89 | 39 | 366432 | 1453 | 63121098 |
Dysphonia | 28.29 | 9.89 | 160 | 366311 | 47454 | 63075097 |
Type 2 diabetes mellitus | 28.24 | 9.89 | 522 | 365949 | 63346 | 63059205 |
Transient ischaemic attack | 28.16 | 9.89 | 117 | 366354 | 37636 | 63084915 |
Eye pruritus | 28.13 | 9.89 | 40 | 366431 | 18631 | 63103920 |
Ageusia | 27.79 | 9.89 | 23 | 366448 | 13705 | 63108846 |
Brain oedema | 27.70 | 9.89 | 158 | 366313 | 14037 | 63108514 |
Seizure | 27.49 | 9.89 | 570 | 365901 | 132064 | 62990487 |
Therapeutic response unexpected | 27.47 | 9.89 | 41 | 366430 | 18718 | 63103833 |
Deep vein thrombosis postoperative | 27.29 | 9.89 | 134 | 366337 | 11235 | 63111316 |
Body temperature fluctuation | 27.20 | 9.89 | 48 | 366423 | 2237 | 63120314 |
Liver transplant | 27.11 | 9.89 | 48 | 366423 | 2243 | 63120308 |
Anion gap increased | 27.03 | 9.89 | 43 | 366428 | 1839 | 63120712 |
Fracture | 26.60 | 9.89 | 45 | 366426 | 19539 | 63103012 |
Injection site induration | 26.53 | 9.89 | 10 | 366461 | 9216 | 63113335 |
Carpal tunnel syndrome | 26.33 | 9.89 | 50 | 366421 | 20767 | 63101784 |
Infusion site bruising | 26.12 | 9.89 | 64 | 366407 | 3768 | 63118783 |
Prothrombin time prolonged | 26.09 | 9.89 | 117 | 366354 | 9447 | 63113104 |
Septic shock | 26.08 | 9.89 | 252 | 366219 | 66377 | 63056174 |
Eczema | 26.05 | 9.89 | 97 | 366374 | 32194 | 63090357 |
Hyponatraemia | 25.89 | 9.89 | 472 | 365999 | 111428 | 63011123 |
Hypertensive crisis | 25.88 | 9.89 | 30 | 366441 | 15256 | 63107295 |
Analgesic drug level above therapeutic | 25.86 | 9.89 | 15 | 366456 | 168 | 63122383 |
Panniculitis | 25.73 | 9.89 | 17 | 366454 | 11368 | 63111183 |
Therapeutic response decreased | 25.68 | 9.89 | 229 | 366242 | 61296 | 63061255 |
Brain death | 25.45 | 9.89 | 59 | 366412 | 3351 | 63119200 |
Intervertebral discitis | 25.37 | 9.89 | 57 | 366414 | 3171 | 63119380 |
Red cell distribution width increased | 25.24 | 9.89 | 124 | 366347 | 10400 | 63112151 |
Disturbance in attention | 25.11 | 9.89 | 124 | 366347 | 38065 | 63084486 |
Anti-cyclic citrullinated peptide antibody | 25.10 | 9.89 | 91 | 366380 | 6667 | 63115884 |
Neonatal hypoxia | 24.77 | 9.89 | 24 | 366447 | 611 | 63121940 |
Basal cell carcinoma | 24.65 | 9.89 | 81 | 366390 | 27910 | 63094641 |
Loss of personal independence in daily activities | 24.56 | 9.89 | 404 | 366067 | 96886 | 63025665 |
Skin exfoliation | 24.46 | 9.89 | 147 | 366324 | 42955 | 63079596 |
Vision blurred | 24.45 | 9.89 | 378 | 366093 | 91546 | 63031005 |
Diabetic ketoacidosis | 24.43 | 9.89 | 51 | 366420 | 20454 | 63102097 |
Lip dry | 24.40 | 9.89 | 163 | 366308 | 15307 | 63107244 |
Facet joint syndrome | 24.27 | 9.89 | 136 | 366335 | 12002 | 63110549 |
Cytomegalovirus infection | 24.22 | 9.89 | 53 | 366418 | 20899 | 63101652 |
Respiratory tract congestion | 24.20 | 9.89 | 41 | 366430 | 17791 | 63104760 |
Suicidal ideation | 24.05 | 9.89 | 237 | 366234 | 62184 | 63060367 |
Haematotoxicity | 24.05 | 9.89 | 12 | 366459 | 9364 | 63113187 |
Specific gravity urine decreased | 24.04 | 9.89 | 26 | 366445 | 756 | 63121795 |
Skin necrosis | 24.02 | 9.89 | 27 | 366444 | 13923 | 63108628 |
Pneumocystis jirovecii pneumonia | 23.78 | 9.89 | 38 | 366433 | 16876 | 63105675 |
Dehydration | 23.74 | 9.89 | 791 | 365680 | 172563 | 62949988 |
Pain in extremity | 23.69 | 9.89 | 1621 | 364850 | 329865 | 62792686 |
Frequent bowel movements | 23.63 | 9.89 | 62 | 366409 | 22960 | 63099591 |
Breast cancer female | 23.62 | 9.89 | 26 | 366445 | 13533 | 63109018 |
Urine leukocyte esterase positive | 23.58 | 9.89 | 59 | 366412 | 3520 | 63119031 |
Sepsis | 23.56 | 9.89 | 688 | 365783 | 152435 | 62970116 |
Platelet count decreased | 23.48 | 9.89 | 501 | 365970 | 115621 | 63006930 |
Blood pressure diastolic increased | 23.33 | 9.89 | 117 | 366354 | 9893 | 63112658 |
Drug screen positive | 23.05 | 9.89 | 59 | 366412 | 3570 | 63118981 |
Hyperlipidaemia | 23.04 | 9.89 | 49 | 366422 | 19522 | 63103029 |
Visual acuity reduced | 23.00 | 9.89 | 58 | 366413 | 21768 | 63100783 |
Multiple drug therapy | 22.87 | 9.89 | 59 | 366412 | 3587 | 63118964 |
Renal failure neonatal | 22.82 | 9.89 | 14 | 366457 | 175 | 63122376 |
Multiple sclerosis relapse | 22.70 | 9.89 | 175 | 366296 | 48303 | 63074248 |
Jaundice cholestatic | 22.60 | 9.89 | 93 | 366378 | 7231 | 63115320 |
Metastases to liver | 22.52 | 9.89 | 66 | 366405 | 23573 | 63098978 |
Lung neoplasm malignant | 22.42 | 9.89 | 50 | 366421 | 19583 | 63102968 |
Polyneuropathy | 22.24 | 9.89 | 31 | 366440 | 14558 | 63107993 |
Blood creatine increased | 22.15 | 9.89 | 77 | 366394 | 5524 | 63117027 |
Hypokalaemia | 22.13 | 9.89 | 444 | 366027 | 103360 | 63019191 |
Aspartate aminotransferase increased | 22.12 | 9.89 | 680 | 365791 | 89597 | 63032954 |
Metastases to bone | 22.04 | 9.89 | 56 | 366415 | 20963 | 63101588 |
Haematochezia | 22.04 | 9.89 | 200 | 366271 | 53344 | 63069207 |
Hypothermia | 21.96 | 9.89 | 144 | 366327 | 13437 | 63109114 |
Coronary artery disease | 21.94 | 9.89 | 104 | 366367 | 32273 | 63090278 |
Abdominal pain upper | 21.93 | 9.89 | 1427 | 365044 | 205017 | 62917534 |
Depression | 21.91 | 9.89 | 919 | 365552 | 195573 | 62926978 |
Taste disorder | 21.87 | 9.89 | 28 | 366443 | 13634 | 63108917 |
Ductus arteriosus premature closure | 21.84 | 9.89 | 17 | 366454 | 319 | 63122232 |
Joint stiffness | 21.61 | 9.89 | 147 | 366324 | 41722 | 63080829 |
Palpitations | 21.52 | 9.89 | 491 | 365980 | 112279 | 63010272 |
Leukopenia | 21.18 | 9.89 | 316 | 366155 | 76974 | 63045577 |
Breast cancer | 21.12 | 9.89 | 178 | 366293 | 48205 | 63074346 |
Iron deficiency anaemia | 21.09 | 9.89 | 53 | 366418 | 19916 | 63102635 |
Genital haemorrhage | 21.00 | 9.89 | 8 | 366463 | 7324 | 63115227 |
Foetal exposure during pregnancy | 20.89 | 9.89 | 104 | 366367 | 31858 | 63090693 |
Hypothyroidism | 20.86 | 9.89 | 152 | 366319 | 42480 | 63080071 |
Second primary malignancy | 20.67 | 9.89 | 10 | 366461 | 7943 | 63114608 |
Atrial fibrillation | 20.56 | 9.89 | 514 | 365957 | 116122 | 63006429 |
Complication associated with device | 20.42 | 9.89 | 42 | 366429 | 16936 | 63105615 |
Cardiac disorder | 20.40 | 9.89 | 191 | 366280 | 50625 | 63071926 |
Tremor | 20.38 | 9.89 | 594 | 365877 | 131645 | 62990906 |
Precancerous cells present | 20.36 | 9.89 | 33 | 366438 | 1434 | 63121117 |
Peripheral venous disease | 20.30 | 9.89 | 156 | 366315 | 15321 | 63107230 |
Hypocalcaemia | 20.26 | 9.89 | 104 | 366367 | 31609 | 63090942 |
PCO2 decreased | 20.25 | 9.89 | 31 | 366440 | 1282 | 63121269 |
Swollen tongue | 20.11 | 9.89 | 118 | 366353 | 34682 | 63087869 |
Blood glucose increased | 20.10 | 9.89 | 351 | 366120 | 83405 | 63039146 |
Aphasia | 20.09 | 9.89 | 110 | 366361 | 32890 | 63089661 |
Pathogen resistance | 20.03 | 9.89 | 6 | 366465 | 6392 | 63116159 |
Bacterial test | 19.94 | 9.89 | 29 | 366442 | 1145 | 63121406 |
Smear cervix abnormal | 19.86 | 9.89 | 49 | 366422 | 2897 | 63119654 |
Premature delivery | 19.52 | 9.89 | 99 | 366372 | 30182 | 63092369 |
Extrapyramidal disorder | 19.48 | 9.89 | 29 | 366442 | 13255 | 63109296 |
Weight decreased | 19.37 | 9.89 | 1356 | 365115 | 275442 | 62847109 |
Rheumatoid nodule | 19.34 | 9.89 | 44 | 366427 | 17111 | 63105440 |
Hypomania | 19.23 | 9.89 | 80 | 366391 | 6250 | 63116301 |
Lip swelling | 19.21 | 9.89 | 103 | 366368 | 30960 | 63091591 |
Abdominal distension | 19.21 | 9.89 | 368 | 366103 | 86247 | 63036304 |
Asthma | 19.16 | 9.89 | 575 | 365896 | 126986 | 62995565 |
Parosmia | 19.10 | 9.89 | 6 | 366465 | 6200 | 63116351 |
Hypomagnesaemia | 19.07 | 9.89 | 93 | 366378 | 28644 | 63093907 |
Body height decreased | 19.06 | 9.89 | 18 | 366453 | 10060 | 63112491 |
Neutrophil count decreased | 18.97 | 9.89 | 221 | 366250 | 56185 | 63066366 |
Epilepsy | 18.89 | 9.89 | 86 | 366385 | 26979 | 63095572 |
Neurotoxicity | 18.81 | 9.89 | 44 | 366427 | 16946 | 63105605 |
Inappropriate antidiuretic hormone secretion | 18.81 | 9.89 | 38 | 366433 | 15424 | 63107127 |
Hallucination, auditory | 18.81 | 9.89 | 28 | 366443 | 12796 | 63109755 |
Cholecystitis chronic | 18.71 | 9.89 | 113 | 366358 | 10248 | 63112303 |
Haemolysis | 18.62 | 9.89 | 83 | 366388 | 6685 | 63115866 |
Procedural pain | 18.59 | 9.89 | 63 | 366408 | 21506 | 63101045 |
Skin ulcer | 18.50 | 9.89 | 159 | 366312 | 42886 | 63079665 |
Psoriatic arthropathy | 18.46 | 9.89 | 395 | 366076 | 91125 | 63031426 |
Tinnitus | 18.43 | 9.89 | 125 | 366346 | 35503 | 63087048 |
Blood creatinine decreased | 18.38 | 9.89 | 72 | 366399 | 5473 | 63117078 |
Gestational diabetes | 18.36 | 9.89 | 13 | 366458 | 8383 | 63114168 |
Poor venous access | 18.28 | 9.89 | 147 | 366324 | 14638 | 63107913 |
Femur fracture | 18.05 | 9.89 | 154 | 366317 | 41602 | 63080949 |
Labelled drug-drug interaction medication error | 18.00 | 9.89 | 31 | 366440 | 13368 | 63109183 |
Haemorrhage | 17.94 | 9.89 | 246 | 366225 | 60776 | 63061775 |
Syncope | 17.91 | 9.89 | 528 | 365943 | 116857 | 63005694 |
Febrile bone marrow aplasia | 17.87 | 9.89 | 10 | 366461 | 7315 | 63115236 |
Pulmonary hypertension | 17.86 | 9.89 | 133 | 366338 | 36990 | 63085561 |
Post procedural pulmonary embolism | 17.84 | 9.89 | 14 | 366457 | 266 | 63122285 |
Haemophagocytic lymphohistiocytosis | 17.83 | 9.89 | 21 | 366450 | 10606 | 63111945 |
Administration site erythema | 17.75 | 9.89 | 22 | 366449 | 743 | 63121808 |
Osmolar gap | 17.71 | 9.89 | 10 | 366461 | 106 | 63122445 |
Unresponsive to stimuli | 17.70 | 9.89 | 284 | 366187 | 33532 | 63089019 |
Complication of device removal | 17.67 | 9.89 | 4 | 366467 | 5138 | 63117413 |
Blood urine present | 17.65 | 9.89 | 148 | 366323 | 14921 | 63107630 |
Lupus vulgaris | 17.63 | 9.89 | 75 | 366396 | 5919 | 63116632 |
Cardiomyopathy | 17.56 | 9.89 | 48 | 366423 | 17536 | 63105015 |
Sensitivity to weather change | 17.48 | 9.89 | 10 | 366461 | 7227 | 63115324 |
Pericardial effusion | 17.32 | 9.89 | 102 | 366369 | 29956 | 63092595 |
Anaphylactic shock | 17.16 | 9.89 | 74 | 366397 | 23559 | 63098992 |
Blindness | 16.97 | 9.89 | 66 | 366405 | 21633 | 63100918 |
Mean cell haemoglobin concentration increased | 16.93 | 9.89 | 18 | 366453 | 513 | 63122038 |
Swelling face | 16.88 | 9.89 | 261 | 366210 | 63214 | 63059337 |
Product preparation error | 16.87 | 9.89 | 7 | 366464 | 6085 | 63116466 |
Obstructive airways disorder | 16.81 | 9.89 | 62 | 366409 | 20637 | 63101914 |
Oral discomfort | 16.75 | 9.89 | 17 | 366454 | 9184 | 63113367 |
Fluid retention | 16.71 | 9.89 | 243 | 366228 | 59443 | 63063108 |
Culture urine positive | 16.64 | 9.89 | 53 | 366418 | 3634 | 63118917 |
Thrombosis | 16.64 | 9.89 | 268 | 366203 | 64487 | 63058064 |
Nasal polyps | 16.62 | 9.89 | 7 | 366464 | 6032 | 63116519 |
Renal failure | 16.53 | 9.89 | 535 | 365936 | 117117 | 63005434 |
Gastrointestinal haemorrhage | 16.47 | 9.89 | 350 | 366121 | 80826 | 63041725 |
Haemoglobin urine present | 16.47 | 9.89 | 22 | 366449 | 801 | 63121750 |
Hepatitis cholestatic | 16.46 | 9.89 | 81 | 366390 | 6797 | 63115754 |
Transplant rejection | 16.34 | 9.89 | 23 | 366448 | 10757 | 63111794 |
Death | 16.31 | 9.89 | 2431 | 364040 | 371950 | 62750601 |
Spinal stenosis | 16.24 | 9.89 | 39 | 366432 | 14886 | 63107665 |
Pulmonary arterial hypertension | 16.21 | 9.89 | 71 | 366400 | 22506 | 63100045 |
Vitamin D deficiency | 16.18 | 9.89 | 35 | 366436 | 13857 | 63108694 |
Withdrawal syndrome | 16.17 | 9.89 | 60 | 366411 | 19937 | 63102614 |
Eating disorder | 16.08 | 9.89 | 56 | 366415 | 18960 | 63103591 |
Injection site discolouration | 16.07 | 9.89 | 13 | 366458 | 7835 | 63114716 |
Cough | 16.02 | 9.89 | 1463 | 365008 | 291280 | 62831271 |
Pain | 16.01 | 9.89 | 4648 | 361823 | 735980 | 62386571 |
Bradypnoea | 16.00 | 9.89 | 51 | 366420 | 3499 | 63119052 |
Multiple-drug resistance | 15.91 | 9.89 | 5 | 366466 | 5165 | 63117386 |
Renal papillary necrosis | 15.88 | 9.89 | 13 | 366458 | 263 | 63122288 |
Gout | 15.82 | 9.89 | 33 | 366438 | 13238 | 63109313 |
Lactic acidosis | 15.76 | 9.89 | 143 | 366328 | 38144 | 63084407 |
Electrolyte imbalance | 15.74 | 9.89 | 61 | 366410 | 20015 | 63102536 |
Hyperglycaemia | 15.69 | 9.89 | 160 | 366311 | 41707 | 63080844 |
Laboratory test abnormal | 15.68 | 9.89 | 91 | 366380 | 26821 | 63095730 |
Nail bed inflammation | 15.64 | 9.89 | 15 | 366456 | 377 | 63122174 |
Meniscus injury | 15.58 | 9.89 | 11 | 366460 | 7103 | 63115448 |
Product adhesion issue | 15.57 | 9.89 | 4 | 366467 | 4715 | 63117836 |
Ejection fraction decreased | 15.57 | 9.89 | 71 | 366400 | 22261 | 63100290 |
Band neutrophil count increased | 15.54 | 9.89 | 15 | 366456 | 380 | 63122171 |
Gait disturbance | 15.46 | 9.89 | 882 | 365589 | 182296 | 62940255 |
Intentional self-injury | 15.43 | 9.89 | 86 | 366385 | 25601 | 63096950 |
Osteonecrosis | 15.36 | 9.89 | 81 | 366390 | 24449 | 63098102 |
Respiratory failure | 15.33 | 9.89 | 459 | 366012 | 101399 | 63021152 |
Systemic infection | 15.28 | 9.89 | 4 | 366467 | 4656 | 63117895 |
Pre-existing condition improved | 15.27 | 9.89 | 15 | 366456 | 8229 | 63114322 |
Incorrect drug administration rate | 15.27 | 9.89 | 54 | 366417 | 3908 | 63118643 |
Heavy menstrual bleeding | 15.26 | 9.89 | 52 | 366419 | 17721 | 63104830 |
Post transplant lymphoproliferative disorder | 15.25 | 9.89 | 5 | 366466 | 5026 | 63117525 |
Ear pruritus | 15.24 | 9.89 | 54 | 366417 | 3911 | 63118640 |
Device breakage | 15.24 | 9.89 | 27 | 366444 | 11515 | 63111036 |
Chronic kidney disease | 15.22 | 9.89 | 178 | 366293 | 45220 | 63077331 |
Adjustment disorder with depressed mood | 15.19 | 9.89 | 106 | 366365 | 10098 | 63112453 |
Product dose omission in error | 15.11 | 9.89 | 13 | 366458 | 7599 | 63114952 |
Hemiplegia | 15.04 | 9.89 | 19 | 366452 | 9304 | 63113247 |
Loss of consciousness | 15.00 | 9.89 | 544 | 365927 | 117577 | 63004974 |
Metastases to lung | 14.95 | 9.89 | 32 | 366439 | 12718 | 63109833 |
Drug tolerance | 14.88 | 9.89 | 11 | 366460 | 6938 | 63115613 |
Autoimmune disorder | 14.78 | 9.89 | 158 | 366313 | 17019 | 63105532 |
Hypertransaminasaemia | 14.76 | 9.89 | 10 | 366461 | 6599 | 63115952 |
Rhinorrhoea | 14.73 | 9.89 | 278 | 366193 | 65299 | 63057252 |
Flushing | 14.70 | 9.89 | 551 | 365920 | 74536 | 63048015 |
Delirium | 14.68 | 9.89 | 389 | 366082 | 50152 | 63072399 |
Gastrointestinal pain | 14.67 | 9.89 | 21 | 366450 | 9755 | 63112796 |
Glycosylated haemoglobin increased | 14.63 | 9.89 | 31 | 366440 | 12367 | 63110184 |
Coma hepatic | 14.61 | 9.89 | 19 | 366452 | 674 | 63121877 |
Intentional dose omission | 14.61 | 9.89 | 15 | 366456 | 8060 | 63114491 |
Ventricular arrhythmia | 14.60 | 9.89 | 52 | 366419 | 3776 | 63118775 |
Thrombotic microangiopathy | 14.59 | 9.89 | 24 | 366447 | 10537 | 63112014 |
Flatulence | 14.55 | 9.89 | 129 | 366342 | 34573 | 63087978 |
Fear of injection | 14.51 | 9.89 | 12 | 366459 | 7152 | 63115399 |
Pulmonary toxicity | 14.50 | 9.89 | 20 | 366451 | 9435 | 63113116 |
Impaired work ability | 14.42 | 9.89 | 52 | 366419 | 17423 | 63105128 |
Hepatic encephalopathy | 14.40 | 9.89 | 113 | 366358 | 11169 | 63111382 |
Pain in jaw | 14.40 | 9.89 | 171 | 366300 | 43325 | 63079226 |
Akathisia | 14.38 | 9.89 | 19 | 366452 | 9127 | 63113424 |
Right ventricular failure | 14.28 | 9.89 | 51 | 366420 | 17137 | 63105414 |
Dislocation of vertebra | 14.23 | 9.89 | 92 | 366379 | 8543 | 63114008 |
Cells in urine | 14.20 | 9.89 | 11 | 366460 | 205 | 63122346 |
Vitamin K deficiency | 14.18 | 9.89 | 15 | 366456 | 425 | 63122126 |
Acute graft versus host disease | 14.14 | 9.89 | 4 | 366467 | 4424 | 63118127 |
Ocular hyperaemia | 14.14 | 9.89 | 86 | 366385 | 25058 | 63097493 |
Eosinophil percentage increased | 14.08 | 9.89 | 23 | 366448 | 1006 | 63121545 |
Skin burning sensation | 14.08 | 9.89 | 33 | 366438 | 12701 | 63109850 |
Toxicologic test abnormal | 14.01 | 9.89 | 19 | 366452 | 702 | 63121849 |
Shoulder arthroplasty | 13.98 | 9.89 | 3 | 366468 | 3999 | 63118552 |
Sleep disorder due to a general medical condition | 13.95 | 9.89 | 31 | 366440 | 12157 | 63110394 |
Pulmonary mass | 13.93 | 9.89 | 75 | 366396 | 22521 | 63100030 |
Administration site pruritus | 13.91 | 9.89 | 13 | 366458 | 316 | 63122235 |
Cerebral haemorrhage | 13.89 | 9.89 | 112 | 366359 | 30617 | 63091934 |
Immune reconstitution inflammatory syndrome | 13.87 | 9.89 | 9 | 366462 | 6075 | 63116476 |
Derailment | 13.86 | 9.89 | 7 | 366464 | 58 | 63122493 |
Complication of device insertion | 13.74 | 9.89 | 14 | 366457 | 7550 | 63115001 |
Hepatic cirrhosis | 13.70 | 9.89 | 85 | 366386 | 24649 | 63097902 |
Invasive ductal breast carcinoma | 13.67 | 9.89 | 12 | 366459 | 6946 | 63115605 |
Renal disorder | 13.64 | 9.89 | 123 | 366348 | 32851 | 63089700 |
Alpha 1 microglobulin increased | 13.56 | 9.89 | 7 | 366464 | 61 | 63122490 |
Asphyxia | 13.54 | 9.89 | 71 | 366400 | 6110 | 63116441 |
Infusion site urticaria | 13.47 | 9.89 | 29 | 366442 | 1567 | 63120984 |
Ductus arteriosus stenosis foetal | 13.44 | 9.89 | 10 | 366461 | 175 | 63122376 |
Pneumonia viral | 13.43 | 9.89 | 85 | 366386 | 7837 | 63114714 |
Macular oedema | 13.35 | 9.89 | 3 | 366468 | 3874 | 63118677 |
Speech disorder | 13.35 | 9.89 | 160 | 366311 | 40469 | 63082082 |
Product physical issue | 13.35 | 9.89 | 6 | 366465 | 4974 | 63117577 |
Anoxia | 13.34 | 9.89 | 11 | 366460 | 225 | 63122326 |
Amenorrhoea | 13.26 | 9.89 | 23 | 366448 | 9891 | 63112660 |
Drug eruption | 13.24 | 9.89 | 104 | 366367 | 28590 | 63093961 |
Encephalopathy | 13.23 | 9.89 | 304 | 366167 | 38316 | 63084235 |
Blood immunoglobulin E increased | 13.21 | 9.89 | 3 | 366468 | 3846 | 63118705 |
Intestinal haemorrhage | 13.20 | 9.89 | 3 | 366468 | 3844 | 63118707 |
Urine ketone body present | 13.20 | 9.89 | 38 | 366433 | 2465 | 63120086 |
Drug abuser | 13.18 | 9.89 | 42 | 366429 | 2881 | 63119670 |
Transfusion-related acute lung injury | 13.16 | 9.89 | 9 | 366462 | 137 | 63122414 |
Thinking abnormal | 13.08 | 9.89 | 26 | 366445 | 10617 | 63111934 |
Bone density decreased | 13.06 | 9.89 | 42 | 366429 | 14570 | 63107981 |
Transaminases increased | 13.05 | 9.89 | 254 | 366217 | 31113 | 63091438 |
Continuous haemodiafiltration | 13.03 | 9.89 | 22 | 366449 | 989 | 63121562 |
Tardive dyskinesia | 13.02 | 9.89 | 18 | 366453 | 8484 | 63114067 |
Infusion site irritation | 13.01 | 9.89 | 21 | 366450 | 909 | 63121642 |
Blood bilirubin increased | 12.93 | 9.89 | 293 | 366178 | 36847 | 63085704 |
Traumatic liver injury | 12.86 | 9.89 | 12 | 366459 | 291 | 63122260 |
Rebound effect | 12.86 | 9.89 | 5 | 366466 | 4521 | 63118030 |
Galactorrhoea | 12.82 | 9.89 | 4 | 366467 | 4151 | 63118400 |
Nightmare | 12.80 | 9.89 | 62 | 366409 | 19132 | 63103419 |
Hip arthroplasty | 12.78 | 9.89 | 363 | 366108 | 47283 | 63075268 |
Ascites | 12.77 | 9.89 | 162 | 366309 | 40566 | 63081985 |
Metastases to lymph nodes | 12.77 | 9.89 | 17 | 366454 | 8141 | 63114410 |
Joint range of motion decreased | 12.63 | 9.89 | 260 | 366211 | 32168 | 63090383 |
Myelocyte count increased | 12.62 | 9.89 | 13 | 366458 | 357 | 63122194 |
Antidepressant drug level above therapeutic | 12.52 | 9.89 | 14 | 366457 | 423 | 63122128 |
Infusion site mass | 12.49 | 9.89 | 33 | 366438 | 2035 | 63120516 |
Blood uric acid decreased | 12.48 | 9.89 | 19 | 366452 | 782 | 63121769 |
Foot operation | 12.45 | 9.89 | 14 | 366457 | 7217 | 63115334 |
Wound infection | 12.43 | 9.89 | 183 | 366288 | 21227 | 63101324 |
Epstein-Barr virus infection | 12.37 | 9.89 | 17 | 366454 | 8033 | 63114518 |
Urinary tract infection | 12.36 | 9.89 | 1338 | 365133 | 263346 | 62859205 |
Diaphragmatic rupture | 12.34 | 9.89 | 11 | 366460 | 251 | 63122300 |
Base excess | 12.33 | 9.89 | 7 | 366464 | 75 | 63122476 |
Sinus disorder | 12.28 | 9.89 | 87 | 366384 | 24466 | 63098085 |
Infusion site haemorrhage | 12.25 | 9.89 | 60 | 366411 | 5026 | 63117525 |
Uterine cancer | 12.23 | 9.89 | 6 | 366465 | 4727 | 63117824 |
Hunger | 12.20 | 9.89 | 8 | 366463 | 5371 | 63117180 |
Papule | 12.20 | 9.89 | 9 | 366462 | 5682 | 63116869 |
Balance disorder | 12.15 | 9.89 | 600 | 365871 | 83822 | 63038729 |
Skin toxicity | 12.14 | 9.89 | 6 | 366465 | 4708 | 63117843 |
Mood swings | 12.14 | 9.89 | 59 | 366412 | 18189 | 63104362 |
Skin haemorrhage | 12.11 | 9.89 | 25 | 366446 | 10069 | 63112482 |
Neoplasm malignant | 12.09 | 9.89 | 112 | 366359 | 29749 | 63092802 |
Pregnancy with contraceptive device | 12.05 | 9.89 | 6 | 366465 | 4688 | 63117863 |
Hepatitis acute | 12.01 | 9.89 | 92 | 366379 | 9028 | 63113523 |
Dyslipidaemia | 11.99 | 9.89 | 15 | 366456 | 7378 | 63115173 |
Urine analysis abnormal | 11.95 | 9.89 | 59 | 366412 | 4957 | 63117594 |
Coagulation factor X level decreased | 11.95 | 9.89 | 7 | 366464 | 80 | 63122471 |
Acute myocardial infarction | 11.94 | 9.89 | 123 | 366348 | 32001 | 63090550 |
Endophthalmitis | 11.94 | 9.89 | 3 | 366468 | 3589 | 63118962 |
Device leakage | 11.93 | 9.89 | 14 | 366457 | 7082 | 63115469 |
Cardiac failure acute | 11.93 | 9.89 | 23 | 366448 | 9500 | 63113051 |
Angina unstable | 11.93 | 9.89 | 14 | 366457 | 7081 | 63115470 |
Intermenstrual bleeding | 11.92 | 9.89 | 17 | 366454 | 7909 | 63114642 |
Anxiety | 11.91 | 9.89 | 1087 | 365384 | 216454 | 62906097 |
Treatment noncompliance | 11.88 | 9.89 | 148 | 366323 | 37177 | 63085374 |
Hypercholesterolaemia | 11.86 | 9.89 | 181 | 366290 | 21153 | 63101398 |
Erysipelas | 11.85 | 9.89 | 17 | 366454 | 7888 | 63114663 |
Abnormal dreams | 11.83 | 9.89 | 27 | 366444 | 10489 | 63112062 |
Autonomic dysreflexia | 11.81 | 9.89 | 12 | 366459 | 324 | 63122227 |
Febrile neutropenia | 11.76 | 9.89 | 561 | 365910 | 117888 | 63004663 |
Ankylosing spondylitis | 11.69 | 9.89 | 27 | 366444 | 10447 | 63112104 |
Dyspnoea | 11.68 | 9.89 | 3524 | 362947 | 657789 | 62464762 |
Vertigo | 11.63 | 9.89 | 260 | 366211 | 59627 | 63062924 |
Diffuse large B-cell lymphoma | 11.55 | 9.89 | 13 | 366458 | 6699 | 63115852 |
Insurance issue | 11.50 | 9.89 | 11 | 366460 | 6110 | 63116441 |
Metastases to central nervous system | 11.49 | 9.89 | 38 | 366433 | 13067 | 63109484 |
Sleep apnoea syndrome | 11.48 | 9.89 | 110 | 366361 | 29023 | 63093528 |
Lumbar vertebral fracture | 11.44 | 9.89 | 10 | 366461 | 5800 | 63116751 |
Transplant dysfunction | 11.39 | 9.89 | 7 | 366464 | 4865 | 63117686 |
Rheumatoid lung | 11.36 | 9.89 | 4 | 366467 | 3844 | 63118707 |
Accident at home | 11.34 | 9.89 | 9 | 366462 | 174 | 63122377 |
Therapy change | 11.34 | 9.89 | 11 | 366460 | 6070 | 63116481 |
Infective pulmonary exacerbation of cystic fibrosis | 11.31 | 9.89 | 21 | 366450 | 8796 | 63113755 |
Low density lipoprotein increased | 11.28 | 9.89 | 12 | 366459 | 6345 | 63116206 |
Product monitoring error | 11.25 | 9.89 | 6 | 366465 | 4510 | 63118041 |
Dysphagia | 11.24 | 9.89 | 408 | 366063 | 88177 | 63034374 |
Product administration interrupted | 11.23 | 9.89 | 7 | 366464 | 4829 | 63117722 |
Metastases to peritoneum | 11.20 | 9.89 | 3 | 366468 | 3439 | 63119112 |
Administration site extravasation | 11.14 | 9.89 | 20 | 366451 | 945 | 63121606 |
Colitis | 11.12 | 9.89 | 205 | 366266 | 48323 | 63074228 |
Activated partial thromboplastin time prolonged | 11.09 | 9.89 | 73 | 366398 | 6820 | 63115731 |
Polycystic ovaries | 11.06 | 9.89 | 6 | 366465 | 4465 | 63118086 |
Coagulation factor VII level decreased | 11.05 | 9.89 | 7 | 366464 | 93 | 63122458 |
Intervertebral disc degeneration | 10.97 | 9.89 | 50 | 366421 | 15682 | 63106869 |
Eye irritation | 10.91 | 9.89 | 78 | 366393 | 21893 | 63100658 |
Atypical femur fracture | 10.88 | 9.89 | 9 | 366462 | 5363 | 63117188 |
Band neutrophil percentage increased | 10.87 | 9.89 | 10 | 366461 | 238 | 63122313 |
Excessive skin | 10.85 | 9.89 | 8 | 366463 | 138 | 63122413 |
Corneal reflex decreased | 10.80 | 9.89 | 8 | 366463 | 139 | 63122412 |
Maternal exposure timing unspecified | 10.77 | 9.89 | 74 | 366397 | 7013 | 63115538 |
Drug-induced liver injury | 10.67 | 9.89 | 306 | 366165 | 39916 | 63082635 |
C-reactive protein | 10.64 | 9.89 | 56 | 366415 | 4826 | 63117725 |
Administration site reaction | 10.63 | 9.89 | 10 | 366461 | 245 | 63122306 |
Cytopenia | 10.61 | 9.89 | 33 | 366438 | 11568 | 63110983 |
Chronic obstructive pulmonary disease | 10.57 | 9.89 | 278 | 366193 | 62408 | 63060143 |
Urinary casts | 10.50 | 9.89 | 17 | 366454 | 738 | 63121813 |
Mental impairment | 10.46 | 9.89 | 44 | 366427 | 14107 | 63108444 |
Delusion | 10.43 | 9.89 | 35 | 366436 | 11982 | 63110569 |
Accidental death | 10.42 | 9.89 | 30 | 366441 | 1946 | 63120605 |
Uterine perforation | 10.41 | 9.89 | 15 | 366456 | 6948 | 63115603 |
Urine oxalate increased | 10.40 | 9.89 | 10 | 366461 | 252 | 63122299 |
Partial seizures | 10.40 | 9.89 | 11 | 366460 | 5831 | 63116720 |
Dry eye | 10.37 | 9.89 | 169 | 366302 | 40592 | 63081959 |
Bacterial test positive | 10.31 | 9.89 | 59 | 366412 | 5248 | 63117303 |
Blood methaemoglobin present | 10.28 | 9.89 | 6 | 366465 | 68 | 63122483 |
Cytomegalovirus infection reactivation | 10.27 | 9.89 | 5 | 366466 | 3958 | 63118593 |
Cardiogenic shock | 10.26 | 9.89 | 61 | 366410 | 17871 | 63104680 |
Eye haemorrhage | 10.23 | 9.89 | 21 | 366450 | 8475 | 63114076 |
Gastroenteritis | 10.22 | 9.89 | 101 | 366370 | 26489 | 63096062 |
Hysterectomy | 10.20 | 9.89 | 25 | 366446 | 9474 | 63113077 |
Blood lactic acid increased | 10.19 | 9.89 | 73 | 366398 | 7013 | 63115538 |
Sleep disorder | 10.18 | 9.89 | 572 | 365899 | 80994 | 63041557 |
Extra dose administered | 10.18 | 9.89 | 13 | 366458 | 6337 | 63116214 |
Acute respiratory failure | 10.14 | 9.89 | 139 | 366332 | 34346 | 63088205 |
Organising pneumonia | 10.14 | 9.89 | 11 | 366460 | 5765 | 63116786 |
Dermatitis | 10.07 | 9.89 | 57 | 366414 | 16901 | 63105650 |
Anosmia | 10.04 | 9.89 | 15 | 366456 | 6845 | 63115706 |
Glucose tolerance impaired | 10.00 | 9.89 | 14 | 366457 | 6563 | 63115988 |
Device deployment issue | 10.00 | 9.89 | 5 | 366466 | 3897 | 63118654 |
Acute myeloid leukaemia | 9.98 | 9.89 | 58 | 366413 | 17089 | 63105462 |
Appendix disorder | 9.96 | 9.89 | 25 | 366446 | 1494 | 63121057 |
Pleural effusion | 9.95 | 9.89 | 438 | 366033 | 92772 | 63029779 |
Gallbladder injury | 9.95 | 9.89 | 24 | 366447 | 1399 | 63121152 |
Osmolar gap abnormal | 9.94 | 9.89 | 5 | 366466 | 41 | 63122510 |
Pancreatic carcinoma | 9.93 | 9.89 | 18 | 366453 | 7610 | 63114941 |
Temperature regulation disorder | 9.90 | 9.89 | 65 | 366406 | 6067 | 63116484 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Completed suicide | 1408.85 | 10.18 | 1840 | 137350 | 96328 | 34721413 |
Toxicity to various agents | 1196.28 | 10.18 | 2528 | 136662 | 197834 | 34619907 |
Infusion related reaction | 424.04 | 10.18 | 759 | 138431 | 52298 | 34765443 |
Overdose | 405.40 | 10.18 | 1026 | 138164 | 90033 | 34727708 |
Blood pressure fluctuation | 319.42 | 10.18 | 446 | 138744 | 24803 | 34792938 |
Acute hepatic failure | 273.11 | 10.18 | 308 | 138882 | 13766 | 34803975 |
Exposure to toxic agent | 261.65 | 10.18 | 170 | 139020 | 3505 | 34814236 |
Drug ineffective | 245.41 | 10.18 | 964 | 138226 | 455787 | 34361954 |
Intentional product misuse | 220.76 | 10.18 | 531 | 138659 | 45080 | 34772661 |
Intentional overdose | 200.24 | 10.18 | 498 | 138692 | 43176 | 34774565 |
Heart rate decreased | 132.03 | 10.18 | 349 | 138841 | 31396 | 34786345 |
Metabolic acidosis | 125.32 | 10.18 | 421 | 138769 | 43259 | 34774482 |
Blood pressure increased | 115.35 | 10.18 | 671 | 138519 | 87431 | 34730310 |
Cardio-respiratory arrest | 111.51 | 10.18 | 476 | 138714 | 54797 | 34762944 |
Product dose omission issue | 109.46 | 10.18 | 193 | 138997 | 119518 | 34698223 |
Respiratory arrest | 104.35 | 10.18 | 296 | 138894 | 27747 | 34789994 |
Coagulopathy | 98.50 | 10.18 | 233 | 138957 | 19556 | 34798185 |
Oxygen saturation decreased | 89.59 | 10.18 | 438 | 138752 | 53380 | 34764361 |
Hepatotoxicity | 86.08 | 10.18 | 233 | 138957 | 21252 | 34796489 |
Anion gap | 84.45 | 10.18 | 49 | 139141 | 818 | 34816923 |
Accidental overdose | 77.29 | 10.18 | 215 | 138975 | 19925 | 34797816 |
Substance abuse | 75.12 | 10.18 | 120 | 139070 | 7521 | 34810220 |
Diarrhoea | 74.94 | 10.18 | 1098 | 138092 | 388814 | 34428927 |
Hepatic necrosis | 70.15 | 10.18 | 81 | 139109 | 3713 | 34814028 |
Hypotension | 68.14 | 10.18 | 1250 | 137940 | 220399 | 34597342 |
Neonatal hypoxia | 68.08 | 10.18 | 33 | 139157 | 374 | 34817367 |
Drug resistance | 63.33 | 10.18 | 13 | 139177 | 25914 | 34791827 |
Alanine aminotransferase increased | 63.07 | 10.18 | 543 | 138647 | 80272 | 34737469 |
Chills | 62.45 | 10.18 | 543 | 138647 | 80500 | 34737241 |
Treatment failure | 60.43 | 10.18 | 58 | 139132 | 46639 | 34771102 |
Myocardial infarction | 59.30 | 10.18 | 264 | 138926 | 120821 | 34696920 |
Respiratory depression | 58.03 | 10.18 | 169 | 139021 | 16076 | 34801665 |
Suspected suicide | 57.24 | 10.18 | 82 | 139108 | 4666 | 34813075 |
Heart rate irregular | 57.00 | 10.18 | 165 | 139025 | 15642 | 34802099 |
Sinusitis | 56.52 | 10.18 | 319 | 138871 | 41083 | 34776658 |
Liver injury | 54.32 | 10.18 | 156 | 139034 | 14722 | 34803019 |
Product use in unapproved indication | 52.37 | 10.18 | 265 | 138925 | 117234 | 34700507 |
Cardiac failure congestive | 52.22 | 10.18 | 164 | 139026 | 83106 | 34734635 |
Aspartate aminotransferase increased | 52.13 | 10.18 | 454 | 138736 | 67329 | 34750412 |
Hepatic cytolysis | 51.97 | 10.18 | 151 | 139039 | 14345 | 34803396 |
Medication error | 46.85 | 10.18 | 214 | 138976 | 25351 | 34792390 |
Therapeutic product effect incomplete | 43.90 | 10.18 | 84 | 139106 | 50457 | 34767284 |
Cardiac arrest | 43.90 | 10.18 | 580 | 138610 | 95579 | 34722162 |
Disease progression | 42.53 | 10.18 | 254 | 138936 | 107823 | 34709918 |
Poisoning | 42.53 | 10.18 | 126 | 139064 | 12100 | 34805641 |
International normalised ratio increased | 42.30 | 10.18 | 328 | 138862 | 46999 | 34770742 |
Heart rate increased | 41.87 | 10.18 | 322 | 138868 | 46021 | 34771720 |
Exposure via ingestion | 41.06 | 10.18 | 47 | 139143 | 2134 | 34815607 |
Blood pressure systolic increased | 39.03 | 10.18 | 188 | 139002 | 22764 | 34794977 |
Depressed level of consciousness | 37.23 | 10.18 | 295 | 138895 | 42546 | 34775195 |
Drug abuse | 36.59 | 10.18 | 576 | 138614 | 98520 | 34719221 |
Toxic epidermal necrolysis | 36.59 | 10.18 | 177 | 139013 | 21469 | 34796272 |
Suicide attempt | 36.58 | 10.18 | 274 | 138916 | 38842 | 34778899 |
Analgesic drug level increased | 36.50 | 10.18 | 29 | 139161 | 827 | 34816914 |
Hepatic failure | 36.41 | 10.18 | 249 | 138941 | 34282 | 34783459 |
Cardiac failure | 36.13 | 10.18 | 214 | 138976 | 91034 | 34726707 |
Unresponsive to stimuli | 36.04 | 10.18 | 210 | 138980 | 27359 | 34790382 |
Psoriasis | 35.95 | 10.18 | 62 | 139128 | 38750 | 34778991 |
Neuropathy peripheral | 35.83 | 10.18 | 190 | 139000 | 83073 | 34734668 |
Stevens-Johnson syndrome | 35.63 | 10.18 | 158 | 139032 | 18481 | 34799260 |
Neutrophil percentage increased | 35.35 | 10.18 | 40 | 139150 | 1793 | 34815948 |
Drug ineffective for unapproved indication | 34.91 | 10.18 | 26 | 139164 | 23689 | 34794052 |
Infusion site extravasation | 34.45 | 10.18 | 62 | 139128 | 4282 | 34813459 |
Intentional product use issue | 34.38 | 10.18 | 377 | 138813 | 59439 | 34758302 |
Pulmonary oedema | 34.29 | 10.18 | 314 | 138876 | 47215 | 34770526 |
Body temperature decreased | 34.19 | 10.18 | 122 | 139068 | 12912 | 34804829 |
Pyrexia | 33.42 | 10.18 | 1633 | 137557 | 331380 | 34486361 |
Blood pressure diastolic increased | 32.79 | 10.18 | 66 | 139124 | 4959 | 34812782 |
Product prescribing error | 32.65 | 10.18 | 26 | 139164 | 22901 | 34794840 |
Blood pressure diastolic abnormal | 32.30 | 10.18 | 64 | 139126 | 4754 | 34812987 |
Contraindicated product administered | 31.05 | 10.18 | 24 | 139166 | 21457 | 34796284 |
Pyroglutamic acidosis | 31.04 | 10.18 | 20 | 139170 | 406 | 34817335 |
Renal cortical necrosis | 30.82 | 10.18 | 16 | 139174 | 212 | 34817529 |
Blood pH decreased | 30.65 | 10.18 | 42 | 139148 | 2292 | 34815449 |
Tachycardia | 30.63 | 10.18 | 491 | 138699 | 84281 | 34733460 |
Infusion site pain | 30.59 | 10.18 | 55 | 139135 | 3796 | 34813945 |
Injection site pain | 30.36 | 10.18 | 69 | 139121 | 38936 | 34778805 |
Hospitalisation | 30.34 | 10.18 | 120 | 139070 | 56782 | 34760959 |
Blood pressure diastolic decreased | 30.01 | 10.18 | 92 | 139098 | 9002 | 34808739 |
Prostate cancer | 29.37 | 10.18 | 72 | 139118 | 39577 | 34778164 |
Rheumatoid arthritis | 29.32 | 10.18 | 256 | 138934 | 37982 | 34779759 |
Myocardial fibrosis | 28.14 | 10.18 | 29 | 139161 | 1168 | 34816573 |
Urticaria | 27.93 | 10.18 | 375 | 138815 | 62002 | 34755739 |
Off label use | 27.55 | 10.18 | 1378 | 137812 | 418146 | 34399595 |
Lymphocyte percentage decreased | 27.45 | 10.18 | 38 | 139152 | 2094 | 34815647 |
Memory impairment | 27.36 | 10.18 | 85 | 139105 | 43233 | 34774508 |
Prothrombin time prolonged | 27.25 | 10.18 | 91 | 139099 | 9315 | 34808426 |
Myelosuppression | 26.02 | 10.18 | 23 | 139167 | 19242 | 34798499 |
Sopor | 25.94 | 10.18 | 8 | 139182 | 12128 | 34805613 |
Body temperature increased | 25.83 | 10.18 | 137 | 139053 | 17231 | 34800510 |
Infusion site swelling | 25.31 | 10.18 | 40 | 139150 | 2484 | 34815257 |
Anaemia | 25.17 | 10.18 | 722 | 138468 | 232613 | 34585128 |
Urine sodium decreased | 25.06 | 10.18 | 13 | 139177 | 172 | 34817569 |
Body temperature fluctuation | 24.98 | 10.18 | 32 | 139158 | 1635 | 34816106 |
Aplastic anaemia | 24.68 | 10.18 | 90 | 139100 | 9626 | 34808115 |
Wrong technique in product usage process | 24.62 | 10.18 | 68 | 139122 | 35918 | 34781823 |
Respiratory rate increased | 24.59 | 10.18 | 91 | 139099 | 9803 | 34807938 |
Malignant neoplasm progression | 24.11 | 10.18 | 229 | 138961 | 87817 | 34729924 |
Bladder cancer | 23.76 | 10.18 | 18 | 139172 | 16260 | 34801481 |
Coma | 23.59 | 10.18 | 282 | 138908 | 45396 | 34772345 |
Glycosylated haemoglobin increased | 23.38 | 10.18 | 8 | 139182 | 11352 | 34806389 |
Coronary artery disease | 23.21 | 10.18 | 106 | 139084 | 48199 | 34769542 |
Psoriatic arthropathy | 22.91 | 10.18 | 27 | 139163 | 19771 | 34797970 |
Pulmonary congestion | 22.86 | 10.18 | 112 | 139078 | 13653 | 34804088 |
Acute lung injury | 22.65 | 10.18 | 29 | 139161 | 1481 | 34816260 |
Dizziness | 22.35 | 10.18 | 681 | 138509 | 217840 | 34599901 |
Cerebral artery thrombosis | 22.24 | 10.18 | 21 | 139169 | 759 | 34816982 |
Methaemoglobinaemia | 22.14 | 10.18 | 46 | 139144 | 3535 | 34814206 |
Full blood count abnormal | 22.10 | 10.18 | 25 | 139165 | 18643 | 34799098 |
Maternal exposure before pregnancy | 21.99 | 10.18 | 21 | 139169 | 770 | 34816971 |
Brain scan abnormal | 21.92 | 10.18 | 22 | 139168 | 858 | 34816883 |
Therapeutic response shortened | 21.78 | 10.18 | 72 | 139118 | 7332 | 34810409 |
Fatigue | 21.57 | 10.18 | 1232 | 137958 | 369421 | 34448320 |
Blood pressure systolic abnormal | 21.31 | 10.18 | 48 | 139142 | 3900 | 34813841 |
Flushing | 21.30 | 10.18 | 210 | 138980 | 32210 | 34785531 |
Diabetes mellitus | 21.26 | 10.18 | 105 | 139085 | 46768 | 34770973 |
Mental status changes | 20.95 | 10.18 | 238 | 138952 | 37845 | 34779896 |
Ductus arteriosus premature closure | 20.88 | 10.18 | 13 | 139177 | 248 | 34817493 |
Abdominal pain | 20.46 | 10.18 | 821 | 138369 | 162797 | 34654944 |
Acidosis | 20.33 | 10.18 | 92 | 139098 | 10853 | 34806888 |
Progressive multifocal leukoencephalopathy | 19.88 | 10.18 | 7 | 139183 | 9757 | 34807984 |
Brain oedema | 19.86 | 10.18 | 108 | 139082 | 13713 | 34804028 |
Haemolysis | 19.75 | 10.18 | 74 | 139116 | 8020 | 34809721 |
Depression | 19.73 | 10.18 | 270 | 138920 | 96828 | 34720913 |
Brain death | 19.65 | 10.18 | 37 | 139153 | 2646 | 34815095 |
Loss of personal independence in daily activities | 19.64 | 10.18 | 67 | 139123 | 33112 | 34784629 |
Adrenergic syndrome | 19.29 | 10.18 | 9 | 139181 | 93 | 34817648 |
No adverse event | 19.13 | 10.18 | 39 | 139151 | 22888 | 34794853 |
Asthma | 19.09 | 10.18 | 96 | 139094 | 42560 | 34775181 |
Asthenia | 18.77 | 10.18 | 792 | 138398 | 244459 | 34573282 |
Throat tightness | 18.42 | 10.18 | 74 | 139116 | 8284 | 34809457 |
Oesophageal carcinoma | 18.39 | 10.18 | 7 | 139183 | 9297 | 34808444 |
Haematotoxicity | 18.25 | 10.18 | 5 | 139185 | 8189 | 34809552 |
Interstitial lung disease | 18.21 | 10.18 | 169 | 139021 | 65113 | 34752628 |
Renal impairment | 18.08 | 10.18 | 266 | 138924 | 94247 | 34723494 |
Chronic gastrointestinal bleeding | 17.97 | 10.18 | 13 | 139177 | 321 | 34817420 |
Granulomatosis with polyangiitis | 17.85 | 10.18 | 23 | 139167 | 1182 | 34816559 |
Therapy partial responder | 17.77 | 10.18 | 8 | 139182 | 9608 | 34808133 |
Transaminases increased | 17.74 | 10.18 | 174 | 139016 | 26649 | 34791092 |
Therapy interrupted | 17.73 | 10.18 | 17 | 139173 | 13680 | 34804061 |
Infusion site pruritus | 17.67 | 10.18 | 19 | 139171 | 804 | 34816937 |
Ear infection | 17.53 | 10.18 | 84 | 139106 | 10147 | 34807594 |
Feeling abnormal | 17.51 | 10.18 | 164 | 139026 | 63071 | 34754670 |
Renal papillary necrosis | 17.50 | 10.18 | 10 | 139180 | 162 | 34817579 |
Urethral valves | 17.40 | 10.18 | 12 | 139178 | 274 | 34817467 |
Bone marrow failure | 17.36 | 10.18 | 59 | 139131 | 29194 | 34788547 |
General physical health deterioration | 17.27 | 10.18 | 384 | 138806 | 127885 | 34689856 |
Nasopharyngitis | 17.22 | 10.18 | 382 | 138808 | 69586 | 34748155 |
Inadequate analgesia | 16.99 | 10.18 | 37 | 139153 | 2938 | 34814803 |
Lung neoplasm malignant | 16.83 | 10.18 | 27 | 139163 | 17368 | 34800373 |
Sleep disorder | 16.78 | 10.18 | 67 | 139123 | 31621 | 34786120 |
Febrile neutropenia | 16.71 | 10.18 | 685 | 138505 | 136164 | 34681577 |
Mucosal inflammation | 16.68 | 10.18 | 88 | 139102 | 38534 | 34779207 |
Visual acuity reduced | 16.66 | 10.18 | 24 | 139166 | 16125 | 34801616 |
Immune reconstitution inflammatory syndrome | 16.64 | 10.18 | 7 | 139183 | 8752 | 34808989 |
Dependent personality disorder | 16.63 | 10.18 | 8 | 139182 | 89 | 34817652 |
Oxygen saturation abnormal | 16.39 | 10.18 | 25 | 139165 | 1505 | 34816236 |
Visual impairment | 16.35 | 10.18 | 80 | 139110 | 35722 | 34782019 |
Anion gap abnormal | 16.29 | 10.18 | 10 | 139180 | 186 | 34817555 |
Balance disorder | 16.26 | 10.18 | 95 | 139095 | 40559 | 34777182 |
Accidental death | 15.72 | 10.18 | 32 | 139158 | 2424 | 34815317 |
Labelled drug-drug interaction medication error | 15.61 | 10.18 | 22 | 139168 | 14917 | 34802824 |
Therapeutic response decreased | 15.51 | 10.18 | 62 | 139128 | 29251 | 34788490 |
Cerebral haemorrhage | 15.42 | 10.18 | 79 | 139111 | 34858 | 34782883 |
Bilirubin urine present | 15.32 | 10.18 | 9 | 139181 | 154 | 34817587 |
Monocyte percentage increased | 15.15 | 10.18 | 19 | 139171 | 950 | 34816791 |
Administration site erythema | 15.03 | 10.18 | 7 | 139183 | 72 | 34817669 |
Graft versus host disease | 15.03 | 10.18 | 12 | 139178 | 10557 | 34807184 |
C-reactive protein abnormal | 14.95 | 10.18 | 8 | 139182 | 8702 | 34809039 |
Environmental exposure | 14.88 | 10.18 | 11 | 139179 | 281 | 34817460 |
Failure to suspend medication | 14.86 | 10.18 | 13 | 139177 | 425 | 34817316 |
Fluid retention | 14.78 | 10.18 | 56 | 139134 | 26831 | 34790910 |
Blood triglycerides increased | 14.64 | 10.18 | 21 | 139169 | 14138 | 34803603 |
Cerebral infarction | 14.57 | 10.18 | 58 | 139132 | 27397 | 34790344 |
Post transplant lymphoproliferative disorder | 14.51 | 10.18 | 4 | 139186 | 6524 | 34811217 |
Infusion site rash | 14.49 | 10.18 | 14 | 139176 | 521 | 34817220 |
Osteonecrosis of jaw | 14.45 | 10.18 | 31 | 139159 | 17858 | 34799883 |
Anti-erythrocyte antibody positive | 14.30 | 10.18 | 6 | 139184 | 47 | 34817694 |
Venoocclusive liver disease | 14.14 | 10.18 | 7 | 139183 | 7959 | 34809782 |
Injection site swelling | 14.13 | 10.18 | 15 | 139175 | 11512 | 34806229 |
Therapeutic product effect decreased | 14.00 | 10.18 | 81 | 139109 | 34662 | 34783079 |
Apnoea | 13.89 | 10.18 | 58 | 139132 | 6606 | 34811135 |
Cardiac failure chronic | 13.87 | 10.18 | 7 | 139183 | 7872 | 34809869 |
Pemphigus | 13.87 | 10.18 | 24 | 139166 | 1607 | 34816134 |
Alopecia | 13.86 | 10.18 | 50 | 139140 | 24305 | 34793436 |
Dyspnoea | 13.86 | 10.18 | 1302 | 137888 | 375480 | 34442261 |
Oedema peripheral | 13.85 | 10.18 | 367 | 138823 | 119445 | 34698296 |
Drug interaction | 13.84 | 10.18 | 747 | 138443 | 225199 | 34592542 |
Delirium | 13.77 | 10.18 | 249 | 138941 | 43742 | 34773999 |
Peripheral swelling | 13.75 | 10.18 | 218 | 138972 | 76323 | 34741418 |
Haematocrit decreased | 13.73 | 10.18 | 192 | 138998 | 32024 | 34785717 |
Crohn's disease | 13.70 | 10.18 | 35 | 139155 | 3082 | 34814659 |
Agitation | 13.69 | 10.18 | 312 | 138878 | 57087 | 34760654 |
Dry skin | 13.67 | 10.18 | 71 | 139119 | 31216 | 34786525 |
Pallor | 13.46 | 10.18 | 158 | 139032 | 25322 | 34792419 |
Acid-base balance disorder mixed | 13.30 | 10.18 | 6 | 139184 | 57 | 34817684 |
Blood pressure decreased | 13.23 | 10.18 | 283 | 138907 | 51232 | 34766509 |
Pathogen resistance | 13.19 | 10.18 | 11 | 139179 | 9471 | 34808270 |
Drug screen positive | 13.11 | 10.18 | 40 | 139150 | 3903 | 34813838 |
Myopathy | 13.11 | 10.18 | 16 | 139174 | 11538 | 34806203 |
Endocardial fibrosis | 13.04 | 10.18 | 5 | 139185 | 30 | 34817711 |
Prescribed overdose | 12.89 | 10.18 | 14 | 139176 | 10633 | 34807108 |
Therapy non-responder | 12.87 | 10.18 | 97 | 139093 | 39049 | 34778692 |
Cerebrovascular accident | 12.86 | 10.18 | 249 | 138941 | 84562 | 34733179 |
Throat irritation | 12.79 | 10.18 | 79 | 139111 | 10506 | 34807235 |
Liver transplant | 12.78 | 10.18 | 30 | 139160 | 2504 | 34815237 |
Bacterial test | 12.70 | 10.18 | 8 | 139182 | 156 | 34817585 |
Angina pectoris | 12.70 | 10.18 | 73 | 139117 | 31290 | 34786451 |
Hallucinations, mixed | 12.66 | 10.18 | 31 | 139159 | 2658 | 34815083 |
Pyroglutamate increased | 12.59 | 10.18 | 10 | 139180 | 285 | 34817456 |
COVID-19 | 12.59 | 10.18 | 225 | 138965 | 77325 | 34740416 |
Decreased appetite | 12.57 | 10.18 | 538 | 138652 | 165854 | 34651887 |
Anion gap increased | 12.49 | 10.18 | 25 | 139165 | 1871 | 34815870 |
Ammonia increased | 12.42 | 10.18 | 42 | 139148 | 4327 | 34813414 |
Dermatitis atopic | 12.41 | 10.18 | 3 | 139187 | 5344 | 34812397 |
Blood uric acid increased | 12.39 | 10.18 | 12 | 139178 | 9612 | 34808129 |
Obstructive airways disorder | 12.39 | 10.18 | 27 | 139163 | 15467 | 34802274 |
Poor venous access | 12.32 | 10.18 | 47 | 139143 | 5136 | 34812605 |
Urobilinogen urine increased | 12.29 | 10.18 | 11 | 139179 | 371 | 34817370 |
Administration site pain | 12.27 | 10.18 | 10 | 139180 | 296 | 34817445 |
Areflexia | 12.27 | 10.18 | 33 | 139157 | 2998 | 34814743 |
Tendonitis | 12.23 | 10.18 | 11 | 139179 | 9129 | 34808612 |
Prostatic specific antigen increased | 12.22 | 10.18 | 25 | 139165 | 14655 | 34803086 |
Mydriasis | 12.10 | 10.18 | 59 | 139131 | 7178 | 34810563 |
Cytopenia | 12.08 | 10.18 | 20 | 139170 | 12703 | 34805038 |
Necrotising oesophagitis | 12.04 | 10.18 | 13 | 139177 | 553 | 34817188 |
Adverse event | 11.95 | 10.18 | 37 | 139153 | 18840 | 34798901 |
Infusion site nodule | 11.90 | 10.18 | 7 | 139183 | 120 | 34817621 |
Hyperlipidaemia | 11.88 | 10.18 | 25 | 139165 | 14504 | 34803237 |
Chronic obstructive pulmonary disease | 11.83 | 10.18 | 131 | 139059 | 48787 | 34768954 |
Blood cholesterol increased | 11.81 | 10.18 | 42 | 139148 | 20501 | 34797240 |
Ultrasound liver abnormal | 11.80 | 10.18 | 7 | 139183 | 122 | 34817619 |
Bronchial dysplasia | 11.72 | 10.18 | 5 | 139185 | 41 | 34817700 |
Vomiting | 11.68 | 10.18 | 1141 | 138049 | 246480 | 34571261 |
Hepatitis fulminant | 11.66 | 10.18 | 40 | 139150 | 4150 | 34813591 |
Injection site haemorrhage | 11.65 | 10.18 | 13 | 139177 | 9755 | 34807986 |
Crystal urine present | 11.65 | 10.18 | 12 | 139178 | 483 | 34817258 |
Leukopenia | 11.64 | 10.18 | 178 | 139012 | 62678 | 34755063 |
Urine abnormality | 11.57 | 10.18 | 25 | 139165 | 1974 | 34815767 |
Infusion site erythema | 11.56 | 10.18 | 27 | 139163 | 2246 | 34815495 |
Respiratory distress | 11.56 | 10.18 | 203 | 138987 | 35462 | 34782279 |
Vessel puncture site bruise | 11.51 | 10.18 | 5 | 139185 | 43 | 34817698 |
Adverse drug reaction | 11.50 | 10.18 | 69 | 139121 | 29273 | 34788468 |
Cardiac disorder | 11.44 | 10.18 | 113 | 139077 | 43013 | 34774728 |
Foetal exposure during pregnancy | 11.34 | 10.18 | 97 | 139093 | 38004 | 34779737 |
Abdominal discomfort | 11.23 | 10.18 | 169 | 139021 | 59666 | 34758075 |
Protein urine | 11.20 | 10.18 | 16 | 139174 | 908 | 34816833 |
Hypoxia | 11.19 | 10.18 | 293 | 138897 | 54802 | 34762939 |
Specific gravity urine decreased | 10.90 | 10.18 | 6 | 139184 | 90 | 34817651 |
Leukocytosis | 10.90 | 10.18 | 145 | 139045 | 23920 | 34793821 |
Erythema multiforme | 10.73 | 10.18 | 65 | 139125 | 8584 | 34809157 |
Parkinsonism | 10.65 | 10.18 | 10 | 139180 | 8128 | 34809613 |
Cytomegalovirus infection | 10.49 | 10.18 | 61 | 139129 | 26074 | 34791667 |
Hypomagnesaemia | 10.46 | 10.18 | 48 | 139142 | 21803 | 34795938 |
Urine analysis abnormal | 10.43 | 10.18 | 24 | 139166 | 1977 | 34815764 |
Ureteric obstruction | 10.35 | 10.18 | 18 | 139172 | 1210 | 34816531 |
Acute myocardial infarction | 10.33 | 10.18 | 151 | 139039 | 53568 | 34764173 |
Gait disturbance | 10.31 | 10.18 | 259 | 138931 | 84881 | 34732860 |
Lethargy | 10.26 | 10.18 | 225 | 138965 | 40897 | 34776844 |
Infusion site haemorrhage | 10.19 | 10.18 | 16 | 139174 | 988 | 34816753 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Completed suicide | 4226.50 | 9.63 | 5729 | 403582 | 240038 | 79095039 |
Toxicity to various agents | 3073.47 | 9.63 | 6710 | 402601 | 414830 | 78920247 |
Infusion related reaction | 952.71 | 9.63 | 2970 | 406341 | 227267 | 79107810 |
Overdose | 801.58 | 9.63 | 2419 | 406892 | 181787 | 79153290 |
Acute hepatic failure | 738.78 | 9.63 | 841 | 408470 | 29272 | 79305805 |
Exposure to toxic agent | 687.17 | 9.63 | 482 | 408829 | 8676 | 79326401 |
Intentional product misuse | 592.38 | 9.63 | 1427 | 407884 | 93738 | 79241339 |
Blood pressure fluctuation | 588.46 | 9.63 | 1156 | 408155 | 65989 | 79269088 |
Rheumatoid arthritis | 423.09 | 9.63 | 2152 | 407159 | 206318 | 79128759 |
Metabolic acidosis | 404.91 | 9.63 | 1132 | 408179 | 81397 | 79253680 |
Intentional overdose | 397.69 | 9.63 | 1323 | 407988 | 104637 | 79230440 |
Product dose omission issue | 384.31 | 9.63 | 422 | 408889 | 247115 | 79087962 |
Anion gap | 274.12 | 9.63 | 159 | 409152 | 2022 | 79333055 |
Hepatotoxicity | 269.38 | 9.63 | 722 | 408589 | 50630 | 79284447 |
Duodenal ulcer perforation | 265.73 | 9.63 | 846 | 408465 | 65365 | 79269712 |
Muscle injury | 263.08 | 9.63 | 691 | 408620 | 47870 | 79287207 |
Folliculitis | 250.61 | 9.63 | 738 | 408573 | 54642 | 79280435 |
Respiratory arrest | 250.09 | 9.63 | 756 | 408555 | 56794 | 79278283 |
Cardio-respiratory arrest | 245.54 | 9.63 | 1156 | 408155 | 107354 | 79227723 |
Anti-cyclic citrullinated peptide antibody positive | 245.40 | 9.63 | 960 | 408351 | 82183 | 79252894 |
Irritable bowel syndrome | 243.17 | 9.63 | 788 | 408523 | 61453 | 79273624 |
Helicobacter infection | 241.87 | 9.63 | 848 | 408463 | 68856 | 79266221 |
Heart rate decreased | 238.45 | 9.63 | 849 | 408462 | 69467 | 79265610 |
Hepatic enzyme increased | 233.67 | 9.63 | 1672 | 407639 | 180938 | 79154139 |
Sinusitis | 231.90 | 9.63 | 1758 | 407553 | 193743 | 79141334 |
Injection site pain | 228.39 | 9.63 | 198 | 409113 | 129640 | 79205437 |
Sleep disorder due to general medical condition, insomnia type | 220.04 | 9.63 | 604 | 408707 | 42952 | 79292125 |
Lower respiratory tract infection | 218.71 | 9.63 | 1270 | 408041 | 127950 | 79207127 |
Coagulopathy | 218.63 | 9.63 | 535 | 408776 | 35471 | 79299606 |
Pemphigus | 198.97 | 9.63 | 1024 | 408287 | 98558 | 79236519 |
Hand deformity | 197.59 | 9.63 | 1054 | 408257 | 102865 | 79232212 |
Blood pressure increased | 192.34 | 9.63 | 1791 | 407520 | 209569 | 79125508 |
Diarrhoea | 189.93 | 9.63 | 3280 | 406031 | 877209 | 78457868 |
Pericarditis | 188.59 | 9.63 | 1043 | 408268 | 103193 | 79231884 |
Medication error | 187.70 | 9.63 | 774 | 408537 | 67868 | 79267209 |
Hepatic necrosis | 185.00 | 9.63 | 231 | 409080 | 8869 | 79326208 |
Depressed level of consciousness | 184.92 | 9.63 | 982 | 408329 | 95670 | 79239407 |
Blister | 177.93 | 9.63 | 1136 | 408175 | 118340 | 79216737 |
Nasopharyngitis | 171.84 | 9.63 | 2026 | 407285 | 251855 | 79083222 |
Wound | 171.37 | 9.63 | 1102 | 408209 | 115077 | 79220000 |
Glossodynia | 168.62 | 9.63 | 1006 | 408305 | 102331 | 79232746 |
Anaemia | 167.98 | 9.63 | 1468 | 407843 | 443547 | 78891530 |
Drug ineffective | 158.63 | 9.63 | 4283 | 405028 | 1076630 | 78258447 |
Ill-defined disorder | 155.75 | 9.63 | 711 | 408600 | 65164 | 79269913 |
Discomfort | 155.32 | 9.63 | 1141 | 408170 | 124476 | 79210601 |
Impaired healing | 154.50 | 9.63 | 871 | 408440 | 86784 | 79248293 |
Liver injury | 145.15 | 9.63 | 626 | 408685 | 55988 | 79279089 |
Oxygen saturation decreased | 144.35 | 9.63 | 1145 | 408166 | 127902 | 79207175 |
Myocardial infarction | 144.27 | 9.63 | 474 | 408837 | 183655 | 79151422 |
Poisoning | 143.43 | 9.63 | 366 | 408945 | 24906 | 79310171 |
Systemic lupus erythematosus | 139.96 | 9.63 | 1083 | 408228 | 120066 | 79215011 |
Drug resistance | 137.73 | 9.63 | 25 | 409286 | 42188 | 79292889 |
Body temperature increased | 134.37 | 9.63 | 517 | 408794 | 43903 | 79291174 |
Psoriasis | 133.16 | 9.63 | 158 | 409153 | 89429 | 79245648 |
Joint swelling | 131.59 | 9.63 | 2147 | 407164 | 286499 | 79048578 |
Respiratory depression | 131.53 | 9.63 | 375 | 408936 | 27255 | 79307822 |
Analgesic drug level increased | 127.88 | 9.63 | 116 | 409195 | 3062 | 79332015 |
Injection site erythema | 127.18 | 9.63 | 128 | 409183 | 78069 | 79257008 |
Intentional product use issue | 126.97 | 9.63 | 1266 | 408045 | 150846 | 79184231 |
Hepatic failure | 126.12 | 9.63 | 635 | 408676 | 60577 | 79274500 |
Disease progression | 125.02 | 9.63 | 504 | 408807 | 183858 | 79151219 |
Cardiac failure congestive | 122.63 | 9.63 | 351 | 408960 | 142051 | 79193026 |
Sopor | 118.10 | 9.63 | 15 | 409296 | 32995 | 79302082 |
Suspected suicide | 117.75 | 9.63 | 202 | 409109 | 10374 | 79324703 |
COVID-19 | 117.32 | 9.63 | 415 | 408896 | 157259 | 79177818 |
Cardiac failure | 116.92 | 9.63 | 405 | 408906 | 154437 | 79180640 |
Synovitis | 116.04 | 9.63 | 1234 | 408077 | 149500 | 79185577 |
Weight increased | 114.68 | 9.63 | 2031 | 407280 | 275355 | 79059722 |
Therapeutic product effect decreased | 112.70 | 9.63 | 1312 | 407999 | 162551 | 79172526 |
Exposure via ingestion | 109.46 | 9.63 | 134 | 409177 | 5040 | 79330037 |
Death | 108.45 | 9.63 | 3734 | 405577 | 562780 | 78772297 |
Substance abuse | 108.05 | 9.63 | 194 | 409117 | 10332 | 79324745 |
Wrong technique in product usage process | 106.92 | 9.63 | 133 | 409178 | 73742 | 79261335 |
Creatinine renal clearance decreased | 106.60 | 9.63 | 274 | 409037 | 18728 | 79316349 |
Sedation complication | 106.15 | 9.63 | 243 | 409068 | 15426 | 79319651 |
Neutropenia | 104.94 | 9.63 | 957 | 408354 | 286753 | 79048324 |
Blood calcium decreased | 104.27 | 9.63 | 380 | 408931 | 31439 | 79303638 |
Accidental overdose | 103.25 | 9.63 | 440 | 408871 | 39141 | 79295936 |
Device expulsion | 102.29 | 9.63 | 8 | 409303 | 25853 | 79309224 |
Drug ineffective for unapproved indication | 101.72 | 9.63 | 69 | 409242 | 51169 | 79283908 |
Heart rate irregular | 100.19 | 9.63 | 382 | 408929 | 32297 | 79302780 |
Hypotension | 99.81 | 9.63 | 2962 | 406349 | 437355 | 78897722 |
Drug interaction | 99.60 | 9.63 | 1515 | 407796 | 413668 | 78921409 |
Therapeutic product effect incomplete | 99.34 | 9.63 | 382 | 408929 | 141263 | 79193814 |
Swelling | 99.09 | 9.63 | 1613 | 407698 | 215098 | 79119979 |
Blood pressure diastolic abnormal | 98.68 | 9.63 | 268 | 409043 | 18934 | 79316143 |
Arthropathy | 97.96 | 9.63 | 1362 | 407949 | 175749 | 79159328 |
Off label use | 97.82 | 9.63 | 3740 | 405571 | 903475 | 78431602 |
Product use in unapproved indication | 96.93 | 9.63 | 820 | 408491 | 249539 | 79085538 |
Acute lung injury | 96.08 | 9.63 | 98 | 409213 | 3002 | 79332075 |
Blood pressure diastolic decreased | 94.95 | 9.63 | 356 | 408955 | 29860 | 79305217 |
Heart rate increased | 93.68 | 9.63 | 990 | 408321 | 119734 | 79215343 |
Myelosuppression | 93.23 | 9.63 | 45 | 409266 | 40251 | 79294826 |
Injection site pruritus | 87.95 | 9.63 | 54 | 409257 | 42229 | 79292848 |
Injection site reaction | 86.45 | 9.63 | 92 | 409219 | 54693 | 79280384 |
Interstitial lung disease | 85.33 | 9.63 | 294 | 409017 | 112306 | 79222771 |
Gastrointestinal disorder | 85.13 | 9.63 | 981 | 408330 | 121224 | 79213853 |
Product prescribing error | 84.18 | 9.63 | 64 | 409247 | 44749 | 79290328 |
Coma | 84.10 | 9.63 | 838 | 408473 | 99811 | 79235266 |
Rheumatoid factor positive | 82.97 | 9.63 | 559 | 408752 | 59280 | 79275797 |
Throat irritation | 82.40 | 9.63 | 422 | 408889 | 40524 | 79294553 |
Osteonecrosis of jaw | 82.14 | 9.63 | 61 | 409250 | 43165 | 79291912 |
Injection site swelling | 81.49 | 9.63 | 73 | 409238 | 47059 | 79288018 |
Blood pressure systolic increased | 80.79 | 9.63 | 605 | 408706 | 66381 | 79268696 |
Malignant neoplasm progression | 79.37 | 9.63 | 393 | 408918 | 135597 | 79199480 |
Ear pain | 79.35 | 9.63 | 357 | 408954 | 32512 | 79302565 |
Bone marrow failure | 79.34 | 9.63 | 87 | 409224 | 51020 | 79284057 |
Hospitalisation | 79.13 | 9.63 | 235 | 409076 | 94001 | 79241076 |
Neuropathy peripheral | 78.72 | 9.63 | 415 | 408896 | 140890 | 79194187 |
Hepatic cytolysis | 75.65 | 9.63 | 308 | 409003 | 26843 | 79308234 |
Pyroglutamic acidosis | 74.65 | 9.63 | 54 | 409257 | 1022 | 79334055 |
Alanine aminotransferase increased | 73.90 | 9.63 | 1209 | 408102 | 161361 | 79173716 |
International normalised ratio increased | 73.03 | 9.63 | 710 | 408601 | 84011 | 79251066 |
Injection site bruising | 71.50 | 9.63 | 63 | 409248 | 40939 | 79294138 |
Neutrophil percentage increased | 70.82 | 9.63 | 103 | 409208 | 4586 | 79330491 |
Renal impairment | 70.31 | 9.63 | 497 | 408814 | 157286 | 79177791 |
Cardiac arrest | 68.54 | 9.63 | 1253 | 408058 | 170843 | 79164234 |
Mucosal inflammation | 68.24 | 9.63 | 182 | 409129 | 75398 | 79259679 |
Cognitive disorder | 67.29 | 9.63 | 600 | 408711 | 69326 | 79265751 |
Hypersensitivity | 66.24 | 9.63 | 1789 | 407522 | 260450 | 79074627 |
Pancytopenia | 65.86 | 9.63 | 539 | 408772 | 165206 | 79169871 |
Blood pressure systolic abnormal | 65.22 | 9.63 | 216 | 409095 | 17031 | 79318046 |
Body temperature decreased | 65.17 | 9.63 | 332 | 408979 | 31813 | 79303264 |
Pyroglutamate increased | 64.92 | 9.63 | 42 | 409269 | 657 | 79334420 |
Night sweats | 61.97 | 9.63 | 469 | 408842 | 51626 | 79283451 |
Contraindicated product administered | 61.68 | 9.63 | 1144 | 408167 | 156394 | 79178683 |
Lymphocyte percentage decreased | 60.68 | 9.63 | 99 | 409212 | 4877 | 79330200 |
Anion gap abnormal | 60.06 | 9.63 | 39 | 409272 | 614 | 79334463 |
White blood cells urine positive | 59.86 | 9.63 | 110 | 409201 | 5965 | 79329112 |
Therapy interrupted | 59.84 | 9.63 | 44 | 409267 | 31297 | 79303780 |
Therapy cessation | 59.35 | 9.63 | 63 | 409248 | 37499 | 79297578 |
Crystal urine present | 59.29 | 9.63 | 64 | 409247 | 2096 | 79332981 |
Urine abnormality | 58.50 | 9.63 | 130 | 409181 | 8089 | 79326988 |
Suicide attempt | 58.31 | 9.63 | 667 | 408644 | 82265 | 79252812 |
Blood pH decreased | 57.82 | 9.63 | 94 | 409217 | 4617 | 79330460 |
Respiratory rate increased | 57.79 | 9.63 | 242 | 409069 | 21358 | 79313719 |
Neoplasm progression | 57.60 | 9.63 | 111 | 409200 | 51571 | 79283506 |
Rheumatic fever | 57.40 | 9.63 | 294 | 409017 | 28231 | 79306846 |
Prostate cancer | 56.95 | 9.63 | 52 | 409259 | 33216 | 79301861 |
Stomatitis | 56.51 | 9.63 | 1063 | 408248 | 145694 | 79189383 |
Aspartate aminotransferase increased | 56.45 | 9.63 | 1013 | 408298 | 137628 | 79197449 |
Pneumonia | 55.62 | 9.63 | 2796 | 406515 | 657450 | 78677627 |
Urticaria | 54.89 | 9.63 | 1291 | 408020 | 183910 | 79151167 |
Sedation | 53.96 | 9.63 | 453 | 408858 | 51442 | 79283635 |
Drug abuse | 53.84 | 9.63 | 1152 | 408159 | 161539 | 79173538 |
Coronary artery disease | 53.02 | 9.63 | 166 | 409145 | 65308 | 79269769 |
Diabetes mellitus | 52.66 | 9.63 | 215 | 409096 | 78175 | 79256902 |
Electric shock | 52.43 | 9.63 | 49 | 409262 | 1345 | 79333732 |
Injection site warmth | 52.31 | 9.63 | 7 | 409304 | 14800 | 79320277 |
Blood pressure diastolic increased | 52.23 | 9.63 | 179 | 409132 | 14363 | 79320714 |
Cerebrovascular accident | 52.12 | 9.63 | 527 | 408784 | 154765 | 79180312 |
Loss of personal independence in daily activities | 51.84 | 9.63 | 311 | 409000 | 102269 | 79232808 |
Acute kidney injury | 51.27 | 9.63 | 2162 | 407149 | 517242 | 78817835 |
Prothrombin time prolonged | 50.54 | 9.63 | 196 | 409115 | 16703 | 79318374 |
Body temperature fluctuation | 49.51 | 9.63 | 78 | 409233 | 3729 | 79331348 |
Full blood count abnormal | 48.61 | 9.63 | 83 | 409228 | 40391 | 79294686 |
Septic shock | 48.48 | 9.63 | 400 | 408911 | 122401 | 79212676 |
Bursitis | 47.99 | 9.63 | 332 | 408979 | 35512 | 79299565 |
Flushing | 47.63 | 9.63 | 676 | 408635 | 87592 | 79247485 |
Dyspnoea | 47.60 | 9.63 | 3771 | 405540 | 853254 | 78481823 |
Posterior reversible encephalopathy syndrome | 45.08 | 9.63 | 41 | 409270 | 26240 | 79308837 |
Dyspnoea exertional | 44.52 | 9.63 | 263 | 409048 | 86810 | 79248267 |
Leukopenia | 44.42 | 9.63 | 383 | 408928 | 116130 | 79218947 |
Confusional state | 44.28 | 9.63 | 2026 | 407285 | 315971 | 79019106 |
Palmar-plantar erythrodysaesthesia syndrome | 43.54 | 9.63 | 64 | 409247 | 33070 | 79302007 |
Decreased appetite | 43.51 | 9.63 | 1382 | 407929 | 341036 | 78994041 |
Red blood cell sedimentation rate abnormal | 43.28 | 9.63 | 27 | 409284 | 20936 | 79314141 |
Contusion | 43.13 | 9.63 | 1034 | 408277 | 147742 | 79187335 |
Haematotoxicity | 43.10 | 9.63 | 13 | 409298 | 15506 | 79319571 |
Injection site mass | 43.07 | 9.63 | 25 | 409286 | 20159 | 79314918 |
Feeling abnormal | 43.00 | 9.63 | 567 | 408744 | 158632 | 79176445 |
Unresponsive to stimuli | 42.55 | 9.63 | 456 | 408855 | 55332 | 79279745 |
Swollen joint count increased | 42.49 | 9.63 | 231 | 409080 | 22696 | 79312381 |
Fibromyalgia | 42.36 | 9.63 | 511 | 408800 | 63829 | 79271248 |
Muscle spasticity | 42.28 | 9.63 | 220 | 409091 | 21255 | 79313822 |
Cerebral haemorrhage | 42.07 | 9.63 | 153 | 409158 | 57520 | 79277557 |
Device difficult to use | 41.41 | 9.63 | 9 | 409302 | 13376 | 79321701 |
Cytomegalovirus infection | 41.35 | 9.63 | 99 | 409212 | 42545 | 79292532 |
Product storage error | 40.90 | 9.63 | 16 | 409295 | 16210 | 79318867 |
Oedema peripheral | 40.86 | 9.63 | 984 | 408327 | 251304 | 79083773 |
Brain death | 40.64 | 9.63 | 90 | 409221 | 5587 | 79329490 |
Orthostatic hypotension | 40.51 | 9.63 | 454 | 408857 | 55710 | 79279367 |
No adverse event | 40.47 | 9.63 | 81 | 409230 | 37111 | 79297966 |
Dizziness | 40.38 | 9.63 | 2250 | 407061 | 524191 | 78810886 |
Urinary sediment present | 40.22 | 9.63 | 57 | 409254 | 2478 | 79332599 |
Lymphocyte count decreased | 40.10 | 9.63 | 395 | 408916 | 46894 | 79288183 |
Oesophageal carcinoma | 39.74 | 9.63 | 5 | 409306 | 11079 | 79323998 |
Blood parathyroid hormone decreased | 39.67 | 9.63 | 4 | 409307 | 10532 | 79324545 |
Haematochezia | 39.55 | 9.63 | 275 | 409036 | 87370 | 79247707 |
Hyperkalaemia | 39.31 | 9.63 | 386 | 408925 | 114012 | 79221065 |
Acidosis | 39.29 | 9.63 | 203 | 409108 | 19559 | 79315518 |
Peripheral swelling | 39.10 | 9.63 | 1725 | 407586 | 267892 | 79067185 |
Device issue | 39.01 | 9.63 | 49 | 409262 | 27059 | 79308018 |
Hyperlipidaemia | 38.78 | 9.63 | 46 | 409265 | 26047 | 79309030 |
Labelled drug-drug interaction medication error | 38.74 | 9.63 | 51 | 409260 | 27599 | 79307478 |
Surgery | 38.62 | 9.63 | 68 | 409243 | 32698 | 79302379 |
Epistaxis | 38.01 | 9.63 | 377 | 408934 | 111138 | 79223939 |
Underdose | 37.99 | 9.63 | 70 | 409241 | 33081 | 79301996 |
Product substitution issue | 37.95 | 9.63 | 29 | 409282 | 20227 | 79314850 |
Injection site rash | 37.24 | 9.63 | 23 | 409288 | 17931 | 79317146 |
Atrial fibrillation | 36.84 | 9.63 | 755 | 408556 | 197131 | 79137946 |
Impaired quality of life | 36.57 | 9.63 | 14 | 409297 | 14372 | 79320705 |
Brain oedema | 36.22 | 9.63 | 238 | 409073 | 25025 | 79310052 |
Device malfunction | 36.15 | 9.63 | 34 | 409277 | 21414 | 79313663 |
Dry skin | 36.03 | 9.63 | 203 | 409108 | 67792 | 79267285 |
Immune reconstitution inflammatory syndrome | 35.97 | 9.63 | 13 | 409298 | 13828 | 79321249 |
Drug screen positive | 35.64 | 9.63 | 89 | 409222 | 5974 | 79329103 |
Arthralgia | 35.31 | 9.63 | 3400 | 405911 | 568403 | 78766674 |
Bladder cancer | 35.27 | 9.63 | 29 | 409282 | 19497 | 79315580 |
Lung neoplasm malignant | 35.24 | 9.63 | 55 | 409256 | 27737 | 79307340 |
Anion gap increased | 34.96 | 9.63 | 66 | 409245 | 3654 | 79331423 |
Diabetic ketoacidosis | 34.88 | 9.63 | 77 | 409234 | 34045 | 79301032 |
Pathogen resistance | 34.76 | 9.63 | 15 | 409296 | 14327 | 79320750 |
Haemolysis | 34.63 | 9.63 | 144 | 409167 | 12668 | 79322409 |
Thrombocytopenia | 34.54 | 9.63 | 1067 | 408244 | 264192 | 79070885 |
Injection site haemorrhage | 34.54 | 9.63 | 56 | 409255 | 27814 | 79307263 |
Product quality issue | 34.35 | 9.63 | 77 | 409234 | 33863 | 79301214 |
Urine leukocyte esterase positive | 34.09 | 9.63 | 69 | 409242 | 4022 | 79331055 |
Extrapyramidal disorder | 33.69 | 9.63 | 40 | 409271 | 22639 | 79312438 |
Red blood cells urine positive | 33.65 | 9.63 | 77 | 409234 | 4886 | 79330191 |
Red cell distribution width increased | 33.44 | 9.63 | 161 | 409150 | 15081 | 79319996 |
Dehydration | 33.38 | 9.63 | 994 | 408317 | 247193 | 79087884 |
Specific gravity urine decreased | 33.29 | 9.63 | 31 | 409280 | 847 | 79334230 |
Granuloma skin | 33.23 | 9.63 | 4 | 409307 | 9170 | 79325907 |
Deep vein thrombosis postoperative | 33.21 | 9.63 | 126 | 409185 | 10626 | 79324451 |
Post transplant lymphoproliferative disorder | 32.95 | 9.63 | 9 | 409302 | 11455 | 79323622 |
Analgesic drug level above therapeutic | 32.70 | 9.63 | 24 | 409287 | 465 | 79334612 |
Visual acuity reduced | 32.22 | 9.63 | 64 | 409247 | 29405 | 79305672 |
Glycosylated haemoglobin increased | 31.91 | 9.63 | 31 | 409280 | 19229 | 79315848 |
Acute myocardial infarction | 31.75 | 9.63 | 248 | 409063 | 76788 | 79258289 |
Rash pruritic | 31.71 | 9.63 | 226 | 409085 | 71403 | 79263674 |
Injection site induration | 31.63 | 9.63 | 6 | 409305 | 9813 | 79325264 |
Bacterial test | 31.42 | 9.63 | 35 | 409276 | 1188 | 79333889 |
Mobility decreased | 31.24 | 9.63 | 835 | 408476 | 121340 | 79213737 |
Malaise | 31.19 | 9.63 | 2130 | 407181 | 487739 | 78847338 |
Renal papillary necrosis | 30.79 | 9.63 | 22 | 409289 | 408 | 79334669 |
Hypomagnesaemia | 30.67 | 9.63 | 130 | 409181 | 46781 | 79288296 |
Facet joint syndrome | 30.53 | 9.63 | 127 | 409184 | 11175 | 79323902 |
Device dislocation | 30.51 | 9.63 | 54 | 409257 | 25916 | 79309161 |
Fall | 30.42 | 9.63 | 2124 | 407187 | 485505 | 78849572 |
Liver transplant | 30.41 | 9.63 | 69 | 409242 | 4354 | 79330723 |
Second primary malignancy | 30.30 | 9.63 | 18 | 409293 | 14332 | 79320745 |
Cerebral infarction | 30.22 | 9.63 | 126 | 409185 | 45550 | 79289527 |
Transient ischaemic attack | 29.75 | 9.63 | 154 | 409157 | 52541 | 79282536 |
Illness | 29.73 | 9.63 | 130 | 409181 | 46381 | 79288696 |
Systemic infection | 29.29 | 9.63 | 7 | 409304 | 9745 | 79325332 |
Multiple-drug resistance | 29.20 | 9.63 | 5 | 409306 | 8803 | 79326274 |
Sexual dysfunction | 29.09 | 9.63 | 3 | 409308 | 7760 | 79327317 |
Soft tissue disorder | 28.95 | 9.63 | 59 | 409252 | 3456 | 79331621 |
Unintentional medical device removal | 28.85 | 9.63 | 3 | 409308 | 7709 | 79327368 |
Blood cholesterol increased | 28.71 | 9.63 | 596 | 408715 | 83124 | 79251953 |
Dermatitis atopic | 28.70 | 9.63 | 8 | 409303 | 10048 | 79325029 |
Hypocalcaemia | 28.70 | 9.63 | 145 | 409166 | 49779 | 79285298 |
Pain | 28.69 | 9.63 | 4075 | 405236 | 699727 | 78635350 |
Injury | 28.68 | 9.63 | 558 | 408753 | 76938 | 79258139 |
Urine analysis abnormal | 28.64 | 9.63 | 86 | 409225 | 6434 | 79328643 |
Nausea | 28.44 | 9.63 | 4397 | 404914 | 952799 | 78382278 |
Anti-cyclic citrullinated peptide antibody | 28.41 | 9.63 | 80 | 409231 | 5772 | 79329305 |
Precancerous cells present | 28.40 | 9.63 | 33 | 409278 | 1174 | 79333903 |
Abdominal discomfort | 28.38 | 9.63 | 1566 | 407745 | 249161 | 79085916 |
Myelodysplastic syndrome | 28.09 | 9.63 | 72 | 409239 | 30229 | 79304848 |
Drug hypersensitivity | 28.03 | 9.63 | 1251 | 408060 | 297665 | 79037412 |
Poor venous access | 27.88 | 9.63 | 174 | 409137 | 17975 | 79317102 |
Angioedema | 27.63 | 9.63 | 253 | 409058 | 75782 | 79259295 |
Hyponatraemia | 27.60 | 9.63 | 698 | 408613 | 177150 | 79157927 |
Bilirubin urine present | 27.27 | 9.63 | 19 | 409292 | 338 | 79334739 |
Cytopenia | 27.14 | 9.63 | 39 | 409272 | 20344 | 79314733 |
Memory impairment | 26.96 | 9.63 | 407 | 408904 | 111327 | 79223750 |
Therapeutic response shortened | 26.86 | 9.63 | 156 | 409155 | 15707 | 79319370 |
Jaundice cholestatic | 26.81 | 9.63 | 122 | 409189 | 11162 | 79323915 |
Frequent bowel movements | 26.76 | 9.63 | 71 | 409240 | 29468 | 79305609 |
Hypertensive crisis | 26.43 | 9.63 | 41 | 409270 | 20729 | 79314348 |
Cardiac failure chronic | 26.43 | 9.63 | 12 | 409299 | 11123 | 79323954 |
Smear cervix abnormal | 26.36 | 9.63 | 47 | 409264 | 2489 | 79332588 |
Lip dry | 26.35 | 9.63 | 152 | 409159 | 15266 | 79319811 |
Electrocardiogram QT prolonged | 26.23 | 9.63 | 317 | 408994 | 90069 | 79245008 |
Gait disturbance | 26.20 | 9.63 | 838 | 408473 | 206668 | 79128409 |
Maternal exposure during pregnancy | 26.00 | 9.63 | 900 | 408411 | 135638 | 79199439 |
Culture urine positive | 25.97 | 9.63 | 65 | 409246 | 4370 | 79330707 |
Haematuria | 25.91 | 9.63 | 227 | 409084 | 68609 | 79266468 |
Myalgia | 25.83 | 9.63 | 740 | 408571 | 184901 | 79150176 |
Disturbance in attention | 25.67 | 9.63 | 154 | 409157 | 50647 | 79284430 |
Inappropriate antidiuretic hormone secretion | 25.58 | 9.63 | 61 | 409250 | 26252 | 79308825 |
Product monitoring error | 25.58 | 9.63 | 7 | 409304 | 8899 | 79326178 |
Paraesthesia | 25.52 | 9.63 | 699 | 408612 | 175624 | 79159453 |
Hypercalcaemia | 25.43 | 9.63 | 106 | 409205 | 38324 | 79296753 |
Full blood count decreased | 25.42 | 9.63 | 63 | 409248 | 26756 | 79308321 |
Iron deficiency anaemia | 25.37 | 9.63 | 59 | 409252 | 25613 | 79309464 |
Infusion site pain | 25.05 | 9.63 | 141 | 409170 | 14035 | 79321042 |
Forced expiratory volume decreased | 24.70 | 9.63 | 5 | 409306 | 7809 | 79327268 |
General physical health deterioration | 24.57 | 9.63 | 1158 | 408153 | 274080 | 79060997 |
Infusion site extravasation | 24.55 | 9.63 | 110 | 409201 | 9998 | 79325079 |
Pneumocystis jirovecii pneumonia | 24.53 | 9.63 | 85 | 409226 | 32423 | 79302654 |
Injection site urticaria | 24.49 | 9.63 | 18 | 409293 | 12808 | 79322269 |
Transaminases increased | 24.30 | 9.63 | 387 | 408924 | 51356 | 79283721 |
Syncope | 24.29 | 9.63 | 718 | 408593 | 178731 | 79156346 |
Polyneuropathy | 24.27 | 9.63 | 55 | 409256 | 24096 | 79310981 |
Panniculitis | 24.10 | 9.63 | 17 | 409294 | 12354 | 79322723 |
Acute graft versus host disease | 24.06 | 9.63 | 11 | 409300 | 10156 | 79324921 |
Respiratory disorder | 23.98 | 9.63 | 343 | 408968 | 44513 | 79290564 |
Monocyte percentage increased | 23.97 | 9.63 | 41 | 409270 | 2100 | 79332977 |
Obstructive airways disorder | 23.92 | 9.63 | 82 | 409229 | 31377 | 79303700 |
Epilepsy | 23.87 | 9.63 | 118 | 409193 | 40742 | 79294335 |
Renal failure | 23.86 | 9.63 | 818 | 408493 | 200150 | 79134927 |
Rhinitis allergic | 23.72 | 9.63 | 17 | 409294 | 12252 | 79322825 |
Basal cell carcinoma | 23.57 | 9.63 | 105 | 409206 | 37270 | 79297807 |
Lactic acidosis | 23.50 | 9.63 | 239 | 409072 | 70120 | 79264957 |
Unevaluable event | 23.34 | 9.63 | 178 | 409133 | 55407 | 79279670 |
Hepatic encephalopathy | 23.06 | 9.63 | 207 | 409104 | 23959 | 79311118 |
Endophthalmitis | 22.80 | 9.63 | 3 | 409308 | 6425 | 79328652 |
Thrombotic microangiopathy | 22.75 | 9.63 | 43 | 409268 | 20126 | 79314951 |
Disease recurrence | 22.66 | 9.63 | 133 | 409178 | 43976 | 79291101 |
Eczema | 22.65 | 9.63 | 120 | 409191 | 40698 | 79294379 |
Renal cortical necrosis | 22.58 | 9.63 | 17 | 409294 | 343 | 79334734 |
Blood urine present | 22.19 | 9.63 | 186 | 409125 | 21111 | 79313966 |
Drug intolerance | 22.06 | 9.63 | 1607 | 407704 | 262512 | 79072565 |
Multiple drug therapy | 22.05 | 9.63 | 58 | 409253 | 4020 | 79331057 |
Blood creatinine decreased | 21.98 | 9.63 | 89 | 409222 | 7736 | 79327341 |
Ageusia | 21.97 | 9.63 | 32 | 409279 | 16600 | 79318477 |
Graft versus host disease | 21.79 | 9.63 | 27 | 409284 | 14999 | 79320078 |
Muscle spasms | 21.49 | 9.63 | 708 | 408603 | 174022 | 79161055 |
Aspergillus infection | 21.48 | 9.63 | 41 | 409270 | 19120 | 79315957 |
Cardiomyopathy | 21.20 | 9.63 | 76 | 409235 | 28698 | 79306379 |
Asthenia | 21.18 | 9.63 | 2301 | 407010 | 509388 | 78825689 |
Angina pectoris | 21.10 | 9.63 | 167 | 409144 | 51565 | 79283512 |
Colorectal cancer | 21.02 | 9.63 | 9 | 409302 | 8638 | 79326439 |
Coronary arterial stent insertion | 21.02 | 9.63 | 3 | 409308 | 6041 | 79329036 |
Environmental exposure | 20.91 | 9.63 | 17 | 409294 | 385 | 79334692 |
Cardiac failure acute | 20.79 | 9.63 | 41 | 409270 | 18888 | 79316189 |
Gastrointestinal haemorrhage | 20.76 | 9.63 | 588 | 408723 | 147131 | 79187946 |
Sepsis | 20.70 | 9.63 | 1151 | 408160 | 268277 | 79066800 |
Infusion site pruritus | 20.68 | 9.63 | 57 | 409254 | 4061 | 79331016 |
Aplastic anaemia | 20.62 | 9.63 | 160 | 409151 | 17745 | 79317332 |
Maternal exposure timing unspecified | 20.54 | 9.63 | 71 | 409240 | 5721 | 79329356 |
Asthma | 20.48 | 9.63 | 532 | 408779 | 134563 | 79200514 |
Infusion site swelling | 20.41 | 9.63 | 87 | 409224 | 7739 | 79327338 |
Febrile bone marrow aplasia | 20.39 | 9.63 | 22 | 409289 | 12998 | 79322079 |
PCO2 decreased | 20.36 | 9.63 | 48 | 409263 | 3106 | 79331971 |
Bacterial test positive | 20.35 | 9.63 | 84 | 409227 | 7365 | 79327712 |
Hypothermia | 20.27 | 9.63 | 192 | 409119 | 22554 | 79312523 |
Alopecia | 20.23 | 9.63 | 1413 | 407898 | 229942 | 79105135 |
Haematocrit decreased | 20.22 | 9.63 | 434 | 408877 | 60878 | 79274199 |
Rebound effect | 20.16 | 9.63 | 6 | 409305 | 7220 | 79327857 |
Cholecystitis chronic | 19.86 | 9.63 | 102 | 409209 | 9804 | 79325273 |
Device leakage | 19.76 | 9.63 | 16 | 409295 | 10840 | 79324237 |
Hepatic cirrhosis | 19.71 | 9.63 | 102 | 409209 | 34804 | 79300273 |
Chronic obstructive pulmonary disease | 19.64 | 9.63 | 314 | 408997 | 85105 | 79249972 |
Neurotoxicity | 19.52 | 9.63 | 93 | 409218 | 32425 | 79302652 |
Autoimmune disorder | 19.44 | 9.63 | 149 | 409162 | 16463 | 79318614 |
Chills | 19.35 | 9.63 | 1007 | 408304 | 159227 | 79175850 |
Peripheral venous disease | 19.35 | 9.63 | 144 | 409167 | 15765 | 79319312 |
Acute myeloid leukaemia | 19.33 | 9.63 | 87 | 409224 | 30798 | 79304279 |
Osteonecrosis | 19.22 | 9.63 | 88 | 409223 | 31007 | 79304070 |
White blood cell count decreased | 19.10 | 9.63 | 781 | 408530 | 187507 | 79147570 |
Haemorrhage | 18.98 | 9.63 | 341 | 408970 | 90777 | 79244300 |
Myopathy | 18.95 | 9.63 | 49 | 409262 | 20514 | 79314563 |
Skin exfoliation | 18.88 | 9.63 | 186 | 409125 | 54914 | 79280163 |
Angina unstable | 18.85 | 9.63 | 35 | 409276 | 16492 | 79318585 |
Nasal polyps | 18.84 | 9.63 | 7 | 409304 | 7320 | 79327757 |
Hypertransaminasaemia | 18.84 | 9.63 | 20 | 409291 | 11904 | 79323173 |
Platelet count decreased | 18.78 | 9.63 | 812 | 408499 | 193852 | 79141225 |
Renal cancer | 18.77 | 9.63 | 21 | 409290 | 12205 | 79322872 |
Ear pruritus | 18.76 | 9.63 | 55 | 409256 | 4060 | 79331017 |
Thrombosis | 18.72 | 9.63 | 311 | 409000 | 83789 | 79251288 |
Wound infection | 18.71 | 9.63 | 197 | 409114 | 23794 | 79311283 |
Adrenergic syndrome | 18.69 | 9.63 | 11 | 409300 | 144 | 79334933 |
Brain scan abnormal | 18.67 | 9.63 | 27 | 409284 | 1196 | 79333881 |
Status epilepticus | 18.55 | 9.63 | 66 | 409245 | 24975 | 79310102 |
Urine bilirubin decreased | 18.49 | 9.63 | 11 | 409300 | 147 | 79334930 |
Skin ulcer | 18.47 | 9.63 | 183 | 409128 | 53967 | 79281110 |
Pregnancy | 18.44 | 9.63 | 215 | 409096 | 26636 | 79308441 |
Burning sensation | 18.43 | 9.63 | 202 | 409109 | 58430 | 79276647 |
Spinal stenosis | 18.40 | 9.63 | 33 | 409278 | 15758 | 79319319 |
Sleep disorder due to a general medical condition | 18.35 | 9.63 | 28 | 409283 | 14249 | 79320828 |
Candida infection | 18.19 | 9.63 | 118 | 409193 | 38096 | 79296981 |
Band neutrophil count increased | 18.17 | 9.63 | 20 | 409291 | 670 | 79334407 |
Metastases to lymph nodes | 18.09 | 9.63 | 16 | 409295 | 10381 | 79324696 |
Agranulocytosis | 18.07 | 9.63 | 146 | 409165 | 44884 | 79290193 |
Prostatic specific antigen increased | 18.06 | 9.63 | 16 | 409295 | 10370 | 79324707 |
Pulmonary mass | 18.04 | 9.63 | 82 | 409229 | 28952 | 79306125 |
Infusion site erythema | 18.00 | 9.63 | 96 | 409215 | 9364 | 79325713 |
Joint range of motion decreased | 17.99 | 9.63 | 255 | 409056 | 33027 | 79302050 |
Therapy partial responder | 17.99 | 9.63 | 39 | 409272 | 17358 | 79317719 |
Toxicologic test abnormal | 17.88 | 9.63 | 28 | 409283 | 1332 | 79333745 |
Intervertebral discitis | 17.84 | 9.63 | 60 | 409251 | 4768 | 79330309 |
Adjustment disorder with depressed mood | 17.83 | 9.63 | 93 | 409218 | 8993 | 79326084 |
Cardiac disorder | 17.82 | 9.63 | 234 | 409077 | 65523 | 79269554 |
Hypothyroidism | 17.48 | 9.63 | 178 | 409133 | 52214 | 79282863 |
Insurance issue | 17.45 | 9.63 | 4 | 409307 | 5729 | 79329348 |
Gastric cancer | 17.31 | 9.63 | 16 | 409295 | 10163 | 79324914 |
Pain in extremity | 17.30 | 9.63 | 1623 | 407688 | 362915 | 78972162 |
Cells in urine | 17.29 | 9.63 | 12 | 409299 | 212 | 79334865 |
Mydriasis | 17.28 | 9.63 | 152 | 409159 | 17491 | 79317586 |
Breast cancer female | 17.25 | 9.63 | 20 | 409291 | 11441 | 79323636 |
Fracture | 17.14 | 9.63 | 56 | 409255 | 21745 | 79313332 |
Infection | 17.11 | 9.63 | 1452 | 407859 | 240260 | 79094817 |
Akathisia | 17.04 | 9.63 | 26 | 409285 | 13233 | 79321844 |
Therapeutic response decreased | 17.00 | 9.63 | 241 | 409070 | 66612 | 79268465 |
Eosinophil percentage increased | 16.91 | 9.63 | 29 | 409282 | 1489 | 79333588 |
Mean cell haemoglobin concentration increased | 16.90 | 9.63 | 22 | 409289 | 881 | 79334196 |
Transplant dysfunction | 16.80 | 9.63 | 8 | 409303 | 7213 | 79327864 |
Dyslipidaemia | 16.77 | 9.63 | 21 | 409290 | 11612 | 79323465 |
Skin toxicity | 16.76 | 9.63 | 11 | 409300 | 8303 | 79326774 |
Skin necrosis | 16.75 | 9.63 | 43 | 409268 | 18044 | 79317033 |
Gastrooesophageal reflux disease | 16.74 | 9.63 | 407 | 408904 | 103839 | 79231238 |
Anaphylactic shock | 16.70 | 9.63 | 112 | 409199 | 35884 | 79299193 |
Osmolar gap | 16.68 | 9.63 | 11 | 409300 | 178 | 79334899 |
Dysphonia | 16.68 | 9.63 | 199 | 409112 | 56673 | 79278404 |
Transplant rejection | 16.65 | 9.63 | 48 | 409263 | 19389 | 79315688 |
Vision blurred | 16.59 | 9.63 | 415 | 408896 | 105483 | 79229594 |
Drug abuser | 16.58 | 9.63 | 68 | 409243 | 5945 | 79329132 |
Therapeutic response unexpected | 16.55 | 9.63 | 50 | 409261 | 19896 | 79315181 |
Blood uric acid increased | 16.41 | 9.63 | 27 | 409284 | 13333 | 79321744 |
Delirium | 16.40 | 9.63 | 559 | 408752 | 84068 | 79251009 |
Ejection fraction decreased | 16.34 | 9.63 | 107 | 409204 | 34470 | 79300607 |
Hepatic cancer | 16.26 | 9.63 | 18 | 409293 | 10511 | 79324566 |
Pancreatic carcinoma | 16.16 | 9.63 | 28 | 409283 | 13549 | 79321528 |
Product dose omission in error | 16.12 | 9.63 | 10 | 409301 | 7778 | 79327299 |
Disturbance in social behaviour | 16.09 | 9.63 | 3 | 409308 | 4967 | 79330110 |
Hypomania | 16.05 | 9.63 | 79 | 409232 | 7465 | 79327612 |
Dysgeusia | 16.03 | 9.63 | 202 | 409109 | 56975 | 79278102 |
Subdural haematoma | 16.03 | 9.63 | 95 | 409216 | 31339 | 79303738 |
Ascites | 15.99 | 9.63 | 282 | 409029 | 75280 | 79259797 |
Tachycardia | 15.94 | 9.63 | 1088 | 408223 | 176680 | 79158397 |
Haemoglobin urine present | 15.93 | 9.63 | 22 | 409289 | 933 | 79334144 |
Pruritus | 15.90 | 9.63 | 2284 | 407027 | 392364 | 78942713 |
Metastases to liver | 15.84 | 9.63 | 83 | 409228 | 28231 | 79306846 |
Toxic epidermal necrolysis | 15.82 | 9.63 | 319 | 408992 | 44262 | 79290815 |
Serum sickness | 15.77 | 9.63 | 48 | 409263 | 3618 | 79331459 |
Anti-erythrocyte antibody positive | 15.71 | 9.63 | 8 | 409303 | 77 | 79335000 |
Gynaecomastia | 15.71 | 9.63 | 10 | 409301 | 7671 | 79327406 |
Granulomatosis with polyangiitis | 15.70 | 9.63 | 41 | 409270 | 2829 | 79332248 |
Cytomegalovirus infection reactivation | 15.67 | 9.63 | 13 | 409298 | 8703 | 79326374 |
Cytomegalovirus viraemia | 15.67 | 9.63 | 26 | 409285 | 12795 | 79322282 |
Enthesopathy | 15.67 | 9.63 | 22 | 409289 | 11586 | 79323491 |
Accidental death | 15.57 | 9.63 | 53 | 409258 | 4238 | 79330839 |
Ventricular tachycardia | 15.47 | 9.63 | 139 | 409172 | 41796 | 79293281 |
Carpal tunnel syndrome | 15.46 | 9.63 | 50 | 409261 | 19478 | 79315599 |
Diffuse large B-cell lymphoma | 15.44 | 9.63 | 24 | 409287 | 12125 | 79322952 |
Hepatitis B reactivation | 15.43 | 9.63 | 6 | 409305 | 6102 | 79328975 |
Nocardiosis | 15.34 | 9.63 | 5 | 409306 | 5674 | 79329403 |
Condition aggravated | 15.25 | 9.63 | 2298 | 407013 | 498826 | 78836251 |
Coronary artery bypass | 15.24 | 9.63 | 6 | 409305 | 6056 | 79329021 |
Drug level below therapeutic | 15.21 | 9.63 | 94 | 409217 | 9676 | 79325401 |
Hip arthroplasty | 15.16 | 9.63 | 263 | 409048 | 35493 | 79299584 |
Actinic keratosis | 15.16 | 9.63 | 6 | 409305 | 6036 | 79329041 |
Diplopia | 15.10 | 9.63 | 105 | 409206 | 33361 | 79301716 |
Chronic graft versus host disease | 15.04 | 9.63 | 8 | 409303 | 6773 | 79328304 |
Rheumatoid nodule | 14.99 | 9.63 | 43 | 409268 | 17395 | 79317682 |
Musculoskeletal stiffness | 14.97 | 9.63 | 1067 | 408244 | 173941 | 79161136 |
Specific gravity urine increased | 14.93 | 9.63 | 15 | 409296 | 451 | 79334626 |
Blindness | 14.89 | 9.63 | 85 | 409226 | 28298 | 79306779 |
Sputum culture positive | 14.88 | 9.63 | 48 | 409263 | 3733 | 79331344 |
Dependent personality disorder | 14.77 | 9.63 | 9 | 409302 | 126 | 79334951 |
Metastases to lung | 14.74 | 9.63 | 46 | 409265 | 18117 | 79316960 |
Methaemoglobinaemia | 14.66 | 9.63 | 62 | 409249 | 5495 | 79329582 |
Infusion site mass | 14.64 | 9.63 | 28 | 409283 | 1565 | 79333512 |
Abortion spontaneous | 14.62 | 9.63 | 90 | 409221 | 29417 | 79305660 |
Lupus vulgaris | 14.57 | 9.63 | 44 | 409267 | 3302 | 79331775 |
Blood bicarbonate decreased | 14.55 | 9.63 | 59 | 409252 | 5132 | 79329945 |
Urinary casts | 14.52 | 9.63 | 24 | 409287 | 1195 | 79333882 |
Sinus node dysfunction | 14.46 | 9.63 | 11 | 409300 | 7690 | 79327387 |
Temperature regulation disorder | 14.45 | 9.63 | 64 | 409247 | 5789 | 79329288 |
Mean cell haemoglobin concentration decreased | 14.42 | 9.63 | 54 | 409257 | 4525 | 79330552 |
Tendonitis | 14.40 | 9.63 | 68 | 409243 | 23762 | 79311315 |
Electrolyte imbalance | 14.37 | 9.63 | 96 | 409215 | 30785 | 79304292 |
Epstein-Barr virus infection | 14.35 | 9.63 | 33 | 409278 | 14383 | 79320694 |
Withdrawal syndrome | 14.32 | 9.63 | 80 | 409231 | 26774 | 79308303 |
Rash maculo-papular | 14.31 | 9.63 | 202 | 409109 | 55876 | 79279201 |
Fluid retention | 14.30 | 9.63 | 262 | 409049 | 69547 | 79265530 |
Congestive cardiomyopathy | 14.29 | 9.63 | 24 | 409287 | 11756 | 79323321 |
C-reactive protein | 14.28 | 9.63 | 57 | 409254 | 4922 | 79330155 |
Dyspnoea at rest | 14.27 | 9.63 | 10 | 409301 | 7292 | 79327785 |
Venoocclusive liver disease | 14.26 | 9.63 | 24 | 409287 | 11747 | 79323330 |
Partial seizures | 14.25 | 9.63 | 15 | 409296 | 8963 | 79326114 |
Right ventricular failure | 14.22 | 9.63 | 67 | 409244 | 23430 | 79311647 |
Erysipelas | 14.21 | 9.63 | 21 | 409290 | 10829 | 79324248 |
Pulmonary toxicity | 14.16 | 9.63 | 28 | 409283 | 12886 | 79322191 |
Deep vein thrombosis | 14.15 | 9.63 | 493 | 408818 | 120426 | 79214651 |
Shock haemorrhagic | 14.12 | 9.63 | 54 | 409257 | 20006 | 79315071 |
Post-traumatic stress disorder | 14.10 | 9.63 | 56 | 409255 | 4825 | 79330252 |
Swollen tongue | 14.05 | 9.63 | 145 | 409166 | 42425 | 79292652 |
Thinking abnormal | 14.03 | 9.63 | 29 | 409282 | 13132 | 79321945 |
Pharyngeal paraesthesia | 14.00 | 9.63 | 38 | 409273 | 2683 | 79332394 |
Decerebrate posture | 13.97 | 9.63 | 10 | 409301 | 186 | 79334891 |
Blood triglycerides increased | 13.94 | 9.63 | 58 | 409253 | 20982 | 79314095 |
Mental status changes | 13.92 | 9.63 | 446 | 408865 | 66513 | 79268564 |
Visual impairment | 13.91 | 9.63 | 363 | 408948 | 91768 | 79243309 |
Aphasia | 13.90 | 9.63 | 163 | 409148 | 46569 | 79288508 |
Nocturia | 13.88 | 9.63 | 31 | 409280 | 13650 | 79321427 |
Nasal necrosis | 13.84 | 9.63 | 9 | 409302 | 142 | 79334935 |
Bronchopulmonary aspergillosis | 13.83 | 9.63 | 63 | 409248 | 22231 | 79312846 |
Pulmonary arterial hypertension | 13.80 | 9.63 | 87 | 409224 | 28279 | 79306798 |
Urine ketone body present | 13.79 | 9.63 | 45 | 409266 | 3520 | 79331557 |
Alpha 1 microglobulin increased | 13.78 | 9.63 | 7 | 409304 | 67 | 79335010 |
Encephalopathy | 13.78 | 9.63 | 448 | 408863 | 66949 | 79268128 |
Altered state of consciousness | 13.76 | 9.63 | 151 | 409160 | 43671 | 79291406 |
Loss of consciousness | 13.72 | 9.63 | 713 | 408598 | 167230 | 79167847 |
Seizure | 13.72 | 9.63 | 811 | 408500 | 188023 | 79147054 |
Suicidal ideation | 13.68 | 9.63 | 293 | 409018 | 76047 | 79259030 |
Renal disorder | 13.66 | 9.63 | 144 | 409167 | 41961 | 79293116 |
Hypertriglyceridaemia | 13.64 | 9.63 | 28 | 409283 | 12712 | 79322365 |
Chronic kidney disease | 13.64 | 9.63 | 248 | 409063 | 65906 | 79269171 |
Activated partial thromboplastin time prolonged | 13.64 | 9.63 | 122 | 409189 | 14106 | 79320971 |
Pulmonary embolism | 13.60 | 9.63 | 731 | 408580 | 170923 | 79164154 |
Drug eruption | 13.56 | 9.63 | 152 | 409159 | 43783 | 79291294 |
Balance disorder | 13.54 | 9.63 | 629 | 408682 | 98228 | 79236849 |
Skin burning sensation | 13.52 | 9.63 | 30 | 409281 | 13242 | 79321835 |
Leukocytosis | 13.50 | 9.63 | 305 | 409006 | 43150 | 79291927 |
Blood bilirubin increased | 13.47 | 9.63 | 440 | 408871 | 65792 | 79269285 |
Lymphoproliferative disorder | 13.41 | 9.63 | 6 | 409305 | 5609 | 79329468 |
Urobilinogen urine increased | 13.35 | 9.63 | 17 | 409294 | 666 | 79334411 |
Pain in jaw | 13.34 | 9.63 | 162 | 409149 | 45989 | 79289088 |
Hepatocellular carcinoma | 13.30 | 9.63 | 16 | 409295 | 9005 | 79326072 |
Pyrexia | 13.29 | 9.63 | 3791 | 405520 | 674918 | 78660159 |
Abnormal loss of weight | 13.29 | 9.63 | 14 | 409297 | 8362 | 79326715 |
Respiratory tract congestion | 13.23 | 9.63 | 55 | 409256 | 19899 | 79315178 |
Injection site extravasation | 13.20 | 9.63 | 90 | 409221 | 9579 | 79325498 |
Impaired work ability | 13.20 | 9.63 | 54 | 409257 | 19627 | 79315450 |
Lipodystrophy acquired | 13.20 | 9.63 | 3 | 409308 | 4322 | 79330755 |
Blood glucose increased | 13.17 | 9.63 | 470 | 408841 | 114505 | 79220572 |
Abnormal dreams | 13.16 | 9.63 | 24 | 409287 | 11388 | 79323689 |
Stevens-Johnson syndrome | 13.16 | 9.63 | 278 | 409033 | 38888 | 79296189 |
Fungal rhinitis | 13.10 | 9.63 | 7 | 409304 | 75 | 79335002 |
Dislocation of vertebra | 13.02 | 9.63 | 77 | 409234 | 7803 | 79327274 |
Derailment | 12.94 | 9.63 | 7 | 409304 | 77 | 79335000 |
Metastases to bone | 12.90 | 9.63 | 73 | 409238 | 24354 | 79310723 |
Eye pruritus | 12.84 | 9.63 | 58 | 409253 | 20512 | 79314565 |
Macular oedema | 12.83 | 9.63 | 6 | 409305 | 5468 | 79329609 |
Spinal operation | 12.82 | 9.63 | 13 | 409298 | 7904 | 79327173 |
Anosmia | 12.71 | 9.63 | 16 | 409295 | 8828 | 79326249 |
Accidental poisoning | 12.70 | 9.63 | 27 | 409284 | 1630 | 79333447 |
Diffuse large B-cell lymphoma recurrent | 12.67 | 9.63 | 3 | 409308 | 4204 | 79330873 |
Paradoxical drug reaction | 12.57 | 9.63 | 11 | 409300 | 7174 | 79327903 |
Base excess | 12.56 | 9.63 | 7 | 409304 | 82 | 79334995 |
Speech disorder | 12.56 | 9.63 | 200 | 409111 | 54245 | 79280832 |
Hallucination, auditory | 12.53 | 9.63 | 59 | 409252 | 20634 | 79314443 |
Diaphragmatic rupture | 12.51 | 9.63 | 10 | 409301 | 221 | 79334856 |
Vitamin K deficiency | 12.49 | 9.63 | 17 | 409294 | 711 | 79334366 |
Abdominal pain upper | 12.48 | 9.63 | 1322 | 407989 | 222497 | 79112580 |
Traumatic liver injury | 12.46 | 9.63 | 16 | 409295 | 632 | 79334445 |
Subarachnoid haemorrhage | 12.44 | 9.63 | 74 | 409237 | 24391 | 79310686 |
Tremor | 12.44 | 9.63 | 730 | 408581 | 169353 | 79165724 |
Skin lesion | 12.43 | 9.63 | 146 | 409165 | 41698 | 79293379 |
Carotid artery stenosis | 12.43 | 9.63 | 16 | 409295 | 8742 | 79326335 |
Eosinophilia | 12.42 | 9.63 | 161 | 409150 | 45184 | 79289893 |
Pulmonary hypertension | 12.34 | 9.63 | 173 | 409138 | 47907 | 79287170 |
Blood uric acid decreased | 12.29 | 9.63 | 23 | 409288 | 1265 | 79333812 |
Angiokeratoma | 12.28 | 9.63 | 10 | 409301 | 227 | 79334850 |
Metastases to central nervous system | 12.23 | 9.63 | 43 | 409268 | 16332 | 79318745 |
Procedural pain | 12.18 | 9.63 | 69 | 409242 | 23015 | 79312062 |
Sensitivity to weather change | 12.16 | 9.63 | 14 | 409297 | 8033 | 79327044 |
Hallucination | 12.12 | 9.63 | 341 | 408970 | 85404 | 79249673 |
Blood lactic acid increased | 12.07 | 9.63 | 109 | 409202 | 12635 | 79322442 |
Eyelid ptosis | 12.06 | 9.63 | 24 | 409287 | 11020 | 79324057 |
Ischaemic cardiomyopathy | 12.05 | 9.63 | 13 | 409298 | 7682 | 79327395 |
Graft versus host disease in gastrointestinal tract | 12.03 | 9.63 | 9 | 409302 | 6347 | 79328730 |
Oxygen saturation abnormal | 12.00 | 9.63 | 51 | 409260 | 4531 | 79330546 |
Sleep terror | 11.91 | 9.63 | 4 | 409307 | 4454 | 79330623 |
Gallbladder injury | 11.89 | 9.63 | 22 | 409289 | 1199 | 79333878 |
Carotid artery occlusion | 11.89 | 9.63 | 13 | 409298 | 7634 | 79327443 |
Psychomotor skills impaired | 11.88 | 9.63 | 6 | 409305 | 5231 | 79329846 |
Rash | 11.87 | 9.63 | 3237 | 406074 | 575121 | 78759956 |
Urine oxalate increased | 11.85 | 9.63 | 10 | 409301 | 239 | 79334838 |
Sudden cardiac death | 11.84 | 9.63 | 6 | 409305 | 5219 | 79329858 |
Autonomic dysreflexia | 11.82 | 9.63 | 13 | 409298 | 435 | 79334642 |
Pneumonia viral | 11.77 | 9.63 | 84 | 409227 | 9074 | 79326003 |
Injection site discolouration | 11.77 | 9.63 | 13 | 409298 | 7601 | 79327476 |
pH urine increased | 11.72 | 9.63 | 13 | 409298 | 439 | 79334638 |
Myelocyte percentage increased | 11.68 | 9.63 | 10 | 409301 | 244 | 79334833 |
Genital haemorrhage | 11.66 | 9.63 | 9 | 409302 | 6246 | 79328831 |
Ammonia increased | 11.60 | 9.63 | 73 | 409238 | 7562 | 79327515 |
Dermatitis exfoliative generalised | 11.60 | 9.63 | 12 | 409299 | 7229 | 79327848 |
Pulmonary alveolar haemorrhage | 11.59 | 9.63 | 26 | 409285 | 11431 | 79323646 |
BK virus infection | 11.57 | 9.63 | 17 | 409294 | 8787 | 79326290 |
Skin cancer | 11.57 | 9.63 | 39 | 409272 | 15001 | 79320076 |
Hemiparesis | 11.51 | 9.63 | 114 | 409197 | 33619 | 79301458 |
Hypoglycaemic coma | 11.50 | 9.63 | 5 | 409306 | 4755 | 79330322 |
Endocardial fibrosis | 11.50 | 9.63 | 6 | 409305 | 61 | 79335016 |
Acid-base balance disorder mixed | 11.49 | 9.63 | 7 | 409304 | 98 | 79334979 |
Bone pain | 11.48 | 9.63 | 209 | 409102 | 55533 | 79279544 |
Skin haemorrhage | 11.47 | 9.63 | 28 | 409283 | 11953 | 79323124 |
Transferrin decreased | 11.47 | 9.63 | 12 | 409299 | 379 | 79334698 |
Congestive hepatopathy | 11.44 | 9.63 | 50 | 409261 | 4497 | 79330580 |
Stent placement | 11.39 | 9.63 | 10 | 409301 | 6510 | 79328567 |
Immunosuppressant drug level increased | 11.32 | 9.63 | 18 | 409293 | 9009 | 79326068 |
Ankylosing spondylitis | 11.31 | 9.63 | 29 | 409282 | 12176 | 79322901 |
Extra dose administered | 11.30 | 9.63 | 16 | 409295 | 8399 | 79326678 |
Rash papular | 11.30 | 9.63 | 66 | 409245 | 21850 | 79313227 |
Fear of injection | 11.30 | 9.63 | 13 | 409298 | 7461 | 79327616 |
Vertigo | 11.29 | 9.63 | 269 | 409042 | 68813 | 79266264 |
Ischaemic stroke | 11.29 | 9.63 | 112 | 409199 | 33019 | 79302058 |
Brain stem glioma | 11.25 | 9.63 | 9 | 409302 | 199 | 79334878 |
JC virus infection | 11.24 | 9.63 | 3 | 409308 | 3878 | 79331199 |
Nail bed inflammation | 11.24 | 9.63 | 14 | 409297 | 536 | 79334541 |
Glucose tolerance impaired | 11.23 | 9.63 | 15 | 409296 | 8069 | 79327008 |
Neuroleptic malignant syndrome | 11.22 | 9.63 | 89 | 409222 | 27470 | 79307607 |
Depression | 11.18 | 9.63 | 959 | 408352 | 215831 | 79119246 |
Blood creatine increased | 11.17 | 9.63 | 85 | 409226 | 9370 | 79325707 |
Retinal deposits | 11.17 | 9.63 | 8 | 409303 | 149 | 79334928 |
Drug tolerance | 11.16 | 9.63 | 17 | 409294 | 8658 | 79326419 |
Haemophagocytic lymphohistiocytosis | 11.13 | 9.63 | 66 | 409245 | 21771 | 79313306 |
Treatment noncompliance | 11.08 | 9.63 | 195 | 409116 | 52073 | 79283004 |
Neutrophil count decreased | 11.01 | 9.63 | 383 | 408928 | 93576 | 79241501 |
Rheumatoid lung | 11.01 | 9.63 | 4 | 409307 | 4241 | 79330836 |
Human herpesvirus 6 infection | 10.97 | 9.63 | 7 | 409304 | 5363 | 79329714 |
Lip swelling | 10.93 | 9.63 | 146 | 409165 | 40765 | 79294312 |
Hypokalaemia | 10.93 | 9.63 | 616 | 408695 | 143424 | 79191653 |
Coagulation factor X level decreased | 10.90 | 9.63 | 7 | 409304 | 108 | 79334969 |
Taste disorder | 10.87 | 9.63 | 43 | 409268 | 15780 | 79319297 |
Acute graft versus host disease in skin | 10.86 | 9.63 | 14 | 409297 | 7644 | 79327433 |
Cystitis haemorrhagic | 10.84 | 9.63 | 19 | 409292 | 9153 | 79325924 |
Mitral valve incompetence | 10.84 | 9.63 | 94 | 409217 | 28471 | 79306606 |
Injection site nodule | 10.80 | 9.63 | 3 | 409308 | 3777 | 79331300 |
Cerebral artery thrombosis | 10.80 | 9.63 | 20 | 409291 | 1091 | 79333986 |
Colitis | 10.76 | 9.63 | 290 | 409021 | 73017 | 79262060 |
Bone erosion | 10.74 | 9.63 | 51 | 409260 | 17796 | 79317281 |
Leukoencephalopathy | 10.73 | 9.63 | 15 | 409296 | 7914 | 79327163 |
Left ventricular dysfunction | 10.69 | 9.63 | 57 | 409254 | 19304 | 79315773 |
Tardive dyskinesia | 10.68 | 9.63 | 24 | 409287 | 10547 | 79324530 |
Aortic valve stenosis | 10.68 | 9.63 | 7 | 409304 | 5287 | 79329790 |
Needle issue | 10.67 | 9.63 | 33 | 409278 | 13035 | 79322042 |
Dermatitis acneiform | 10.67 | 9.63 | 22 | 409289 | 9971 | 79325106 |
Dysstasia | 10.66 | 9.63 | 91 | 409220 | 27655 | 79307422 |
Post procedural pulmonary embolism | 10.63 | 9.63 | 10 | 409301 | 277 | 79334800 |
Anti-neutrophil cytoplasmic antibody positive vasculitis | 10.58 | 9.63 | 3 | 409308 | 3726 | 79331351 |
Dermatitis | 10.58 | 9.63 | 65 | 409246 | 21256 | 79313821 |
Gestational diabetes | 10.58 | 9.63 | 10 | 409301 | 6283 | 79328794 |
Band neutrophil percentage increased | 10.55 | 9.63 | 12 | 409299 | 417 | 79334660 |
Vitamin B12 deficiency | 10.51 | 9.63 | 13 | 409298 | 7228 | 79327849 |
Anoxia | 10.45 | 9.63 | 11 | 409300 | 350 | 79334727 |
Osteolysis | 10.44 | 9.63 | 5 | 409306 | 4493 | 79330584 |
Vessel puncture site bruise | 10.41 | 9.63 | 13 | 409298 | 499 | 79334578 |
Atrioventricular block | 10.40 | 9.63 | 37 | 409274 | 14004 | 79321073 |
Rhabdomyolysis | 10.40 | 9.63 | 428 | 408883 | 102703 | 79232374 |
Limb discomfort | 10.39 | 9.63 | 113 | 409198 | 32737 | 79302340 |
Pruritus genital | 10.39 | 9.63 | 5 | 409306 | 4481 | 79330596 |
Tricuspid valve incompetence | 10.36 | 9.63 | 59 | 409252 | 19653 | 79315424 |
Nose deformity | 10.35 | 9.63 | 8 | 409303 | 168 | 79334909 |
Aplasia pure red cell | 10.34 | 9.63 | 15 | 409296 | 7795 | 79327282 |
Soft tissue injury | 10.32 | 9.63 | 26 | 409285 | 1755 | 79333322 |
Mycobacterial infection | 10.32 | 9.63 | 3 | 409308 | 3665 | 79331412 |
Adenocarcinoma of colon | 10.29 | 9.63 | 8 | 409303 | 5533 | 79329544 |
Palpitations | 10.25 | 9.63 | 538 | 408773 | 126072 | 79209005 |
Drug-induced liver injury | 10.23 | 9.63 | 426 | 408885 | 65691 | 79269386 |
Pancreatic pseudoaneurysm | 10.23 | 9.63 | 6 | 409305 | 78 | 79334999 |
Bradycardia neonatal | 10.23 | 9.63 | 6 | 409305 | 78 | 79334999 |
Continuous haemodiafiltration | 10.22 | 9.63 | 28 | 409283 | 1988 | 79333089 |
Flatulence | 10.17 | 9.63 | 156 | 409155 | 42568 | 79292509 |
Organising pneumonia | 10.13 | 9.63 | 26 | 409285 | 10913 | 79324164 |
Accident at home | 10.12 | 9.63 | 8 | 409303 | 174 | 79334903 |
Cerebral ischaemia | 10.07 | 9.63 | 27 | 409284 | 11168 | 79323909 |
Low density lipoprotein increased | 10.06 | 9.63 | 18 | 409293 | 8604 | 79326473 |
Dysarthria | 10.05 | 9.63 | 267 | 409044 | 67355 | 79267722 |
Toxic skin eruption | 10.03 | 9.63 | 70 | 409241 | 22223 | 79312854 |
Excessive skin | 10.02 | 9.63 | 7 | 409304 | 125 | 79334952 |
Cardiovascular disorder | 9.99 | 9.63 | 53 | 409258 | 17972 | 79317105 |
Oral discomfort | 9.99 | 9.63 | 22 | 409289 | 9738 | 79325339 |
Laryngospasm | 9.98 | 9.63 | 4 | 409307 | 3993 | 79331084 |
Prescribed underdose | 9.96 | 9.63 | 100 | 409211 | 29414 | 79305663 |
Sinus tachycardia | 9.93 | 9.63 | 254 | 409057 | 36654 | 79298423 |
Brain herniation | 9.91 | 9.63 | 69 | 409242 | 7394 | 79327683 |
Intestinal haemorrhage | 9.91 | 9.63 | 11 | 409300 | 6415 | 79328662 |
Dysuria | 9.89 | 9.63 | 193 | 409118 | 50758 | 79284319 |
Alcohol use | 9.86 | 9.63 | 50 | 409261 | 4781 | 79330296 |
Magnesium deficiency | 9.85 | 9.63 | 14 | 409297 | 610 | 79334467 |
Graft versus host disease in skin | 9.80 | 9.63 | 10 | 409301 | 6063 | 79329014 |
Respiratory alkalosis | 9.79 | 9.63 | 46 | 409265 | 4265 | 79330812 |
Ductus arteriosus stenosis foetal | 9.79 | 9.63 | 6 | 409305 | 85 | 79334992 |
Cytokine release syndrome | 9.77 | 9.63 | 248 | 409063 | 35750 | 79299327 |
Kidney transplant rejection | 9.76 | 9.63 | 24 | 409287 | 10222 | 79324855 |
Large intestine polyp | 9.74 | 9.63 | 33 | 409278 | 12675 | 79322402 |
Retinal haemorrhage | 9.73 | 9.63 | 17 | 409294 | 8200 | 79326877 |
Bronchiectasis | 9.73 | 9.63 | 71 | 409240 | 22315 | 79312762 |
Multiple organ dysfunction syndrome | 9.72 | 9.63 | 511 | 408800 | 119735 | 79215342 |
Self-medication | 9.71 | 9.63 | 52 | 409259 | 5080 | 79329997 |
Acute respiratory failure | 9.68 | 9.63 | 232 | 409079 | 59309 | 79275768 |
Acute coronary syndrome | 9.68 | 9.63 | 66 | 409245 | 21067 | 79314010 |
Rectal cancer | 9.65 | 9.63 | 3 | 409308 | 3510 | 79331567 |
Monoparesis | 9.64 | 9.63 | 3 | 409308 | 3508 | 79331569 |
Osteomyelitis | 9.63 | 9.63 | 115 | 409196 | 32750 | 79302327 |
None
Source | Code | Description |
---|---|---|
ATC | D11AX26 | DERMATOLOGICALS OTHER DERMATOLOGICAL PREPARATIONS OTHER DERMATOLOGICAL PREPARATIONS Other dermatologicals |
ATC | N06BC01 | NERVOUS SYSTEM PSYCHOANALEPTICS PSYCHOSTIMULANTS, AGENTS USED FOR ADHD AND NOOTROPICS Xanthine derivatives |
ATC | V04CG30 | VARIOUS DIAGNOSTIC AGENTS OTHER DIAGNOSTIC AGENTS Tests for gastric secretion |
FDA CS | M0023046 | Xanthines |
MeSH PA | D002491 | Central Nervous System Agents |
MeSH PA | D000697 | Central Nervous System Stimulants |
MeSH PA | D004791 | Enzyme Inhibitors |
MeSH PA | D018377 | Neurotransmitter Agents |
MeSH PA | D010726 | Phosphodiesterase Inhibitors |
MeSH PA | D058914 | Purinergic Antagonists |
MeSH PA | D058915 | Purinergic P1 Receptor Antagonists |
FDA PE | N0000175729 | Central Nervous System Stimulation |
FDA EPC | N0000175739 | Central Nervous System Stimulant |
FDA EPC | N0000175790 | Methylxanthine |
CHEBI has role | CHEBI:25435 | mutagens |
CHEBI has role | CHEBI:35337 | analeptic |
CHEBI has role | CHEBI:35471 | psychotropic drugs |
CHEBI has role | CHEBI:35498 | diuretics |
CHEBI has role | CHEBI:35703 | Xenobiotic |
CHEBI has role | CHEBI:50218 | phosphodiesterase inhibitors |
CHEBI has role | CHEBI:50925 | serine/threonine protein kinase inhibitor |
CHEBI has role | CHEBI:53121 | adenosine A2A receptor antagonists |
CHEBI has role | CHEBI:60809 | adjuvants |
CHEBI has role | CHEBI:64047 | food additives |
CHEBI has role | CHEBI:67114 | ryanodine receptor activators |
CHEBI has role | CHEBI:71232 | adenosine receptor antagonists |
CHEBI has role | CHEBI:75771 | Mus musculus metabolites |
CHEBI has role | CHEBI:76924 | plant metabolites |
CHEBI has role | CHEBI:76946 | fungal metabolites |
CHEBI has role | CHEBI:78298 | environmental contaminants |
CHEBI has role | CHEBI:85234 | human blood serum metabolites |
CHEBI has role | CHEBI:176497 | geroprotectors |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Sinus headache | indication | 4969004 | |
Apnea in the newborn | indication | 13094009 | |
Pain | indication | 22253000 | |
Migraine | indication | 37796009 | DOID:6364 |
Joint pain | indication | 57676002 | |
Allergic rhinitis | indication | 61582004 | |
Nasal discharge | indication | 64531003 | |
Nasal congestion | indication | 68235000 | |
Common cold | indication | 82272006 | DOID:10459 |
Vascular headache | indication | 128187005 | |
Backache | indication | 161891005 | |
Cluster headache syndrome | indication | 193031009 | |
Spasticity | indication | 221360009 | |
Headache disorder | indication | 230461009 | |
Dysmenorrhea | indication | 266599000 | |
Influenza-like symptoms | indication | 315642008 | |
Tension-type headache | indication | 398057008 | |
Cluster Headache Prevention | indication | ||
Fatigue | off-label use | 84229001 | |
Urinary incontinence | off-label use | 165232002 | |
Obesity | off-label use | 414916001 | DOID:9970 |
Brain damage | contraindication | 2470005 | |
Necrotizing enterocolitis in fetus OR newborn | contraindication | 2707005 | |
Ocular hypertension | contraindication | 4210003 | DOID:9282 |
Gastritis | contraindication | 4556007 | DOID:4029 |
Hypophosphatemia | contraindication | 4996001 | |
Tachyarrhythmia | contraindication | 6285003 | |
Suicidal thoughts | contraindication | 6471006 | |
Dependent drug abuse | contraindication | 6525002 | |
Urinary tract obstruction | contraindication | 7163005 | DOID:5200 |
Alcoholism | contraindication | 7200002 | |
Alcohol withdrawal delirium | contraindication | 8635005 | |
Hyperammonemia | contraindication | 9360008 | |
Peptic ulcer | contraindication | 13200003 | DOID:750 |
Chronic obstructive lung disease | contraindication | 13645005 | DOID:3083 |
Asthenia | contraindication | 13791008 | |
Hepatic encephalopathy | contraindication | 13920009 | DOID:13413 |
Hyperkalemia | contraindication | 14140009 | |
Severe chronic ulcerative colitis | contraindication | 14311001 | |
Constipation | contraindication | 14760008 | DOID:2089 |
Chronic disease of respiratory system | contraindication | 17097001 | |
Mood swings | contraindication | 18963009 | |
Myocardial infarction | contraindication | 22298006 | DOID:5844 |
Glaucoma | contraindication | 23986001 | DOID:1686 |
Inflammatory bowel disease | contraindication | 24526004 | DOID:0050589 |
Ventricular tachycardia | contraindication | 25569003 | |
Alcohol intoxication | contraindication | 25702006 | |
Complete atrioventricular block | contraindication | 27885002 | |
Shock | contraindication | 27942005 | |
Toxic megacolon | contraindication | 28536002 | DOID:1770 |
Hypovolemia | contraindication | 28560003 | |
Orthostatic hypotension | contraindication | 28651003 | |
Acute cerebrovascular insufficiency | contraindication | 29322000 | |
Atony of colon | contraindication | 29479008 | |
Hypercapnia | contraindication | 29596007 | |
Dehydration | contraindication | 34095006 | |
Hyperthyroidism | contraindication | 34486009 | DOID:7998 |
Depressive disorder | contraindication | 35489007 | |
Acute hepatitis | contraindication | 37871000 | |
Hypertensive disorder | contraindication | 38341003 | DOID:10763 |
Disorder of gallbladder | contraindication | 39621005 | DOID:0060262 |
Gastrointestinal ulcer | contraindication | 40845000 | |
Hypothyroidism | contraindication | 40930008 | DOID:1459 |
Complete trisomy 21 syndrome | contraindication | 41040004 | DOID:14250 |
Hypokalemia | contraindication | 43339004 | |
Body fluid retention | contraindication | 43498006 | |
Hyperactive behavior | contraindication | 44548000 | |
Fecal impaction | contraindication | 44635007 | |
Conduction disorder of the heart | contraindication | 44808001 | |
Low blood pressure | contraindication | 45007003 | |
Achalasia of esophagus | contraindication | 45564002 | DOID:9164 |
Chronic heart failure | contraindication | 48447003 | |
Bradycardia | contraindication | 48867003 | |
Retroperitoneal fibrosis | contraindication | 49120005 | |
Disorder of cardiovascular system | contraindication | 49601007 | DOID:1287 |
Acidosis | contraindication | 51387008 | |
Fibrosis of lung | contraindication | 51615001 | DOID:3770 |
Gastrointestinal perforation | contraindication | 51875005 | |
Vitamin K deficiency | contraindication | 52675005 | DOID:11249 |
Nasal polyp | contraindication | 52756005 | |
Gastrectomy | contraindication | 53442002 | |
Paralytic ileus | contraindication | 55525008 | DOID:8442 |
Peptic reflux disease | contraindication | 57643001 | |
Congenital myotonia, autosomal dominant form | contraindication | 57938005 | |
Acute nephropathy | contraindication | 58574008 | |
Leber's optic atrophy | contraindication | 58610003 | DOID:705 |
Hepatic failure | contraindication | 59927004 | |
Diarrhea | contraindication | 62315008 | |
Thrombophlebitis | contraindication | 64156001 | DOID:3875 |
Ulcerative colitis | contraindication | 64766004 | DOID:8577 |
Blood coagulation disorder | contraindication | 64779008 | DOID:1247 |
Arterial thrombosis | contraindication | 65198009 | |
Drug AND/OR toxin-induced diarrhea | contraindication | 65979008 | |
Substance abuse | contraindication | 66214007 | |
Hypermagnesemia | contraindication | 66978005 | |
Benign intracranial hypertension | contraindication | 68267002 | DOID:11459 |
Hemorrhoids | contraindication | 70153002 | DOID:9746 |
Poisoning by acetaminophen | contraindication | 70273001 | |
Agoraphobia | contraindication | 70691001 | DOID:593 |
Arteriosclerotic vascular disease | contraindication | 72092001 | |
Hepatic coma | contraindication | 72836002 | DOID:12550 |
Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
Sleep apnea | contraindication | 73430006 | DOID:0050847 |
Factor II deficiency | contraindication | 73975000 | |
Reye's syndrome | contraindication | 74351001 | DOID:14525 |
Gastrointestinal hemorrhage | contraindication | 74474003 | |
Urethral stricture | contraindication | 76618002 | |
Thrombotic thrombocytopenic purpura | contraindication | 78129009 | DOID:10772 |
Spastic paralysis | contraindication | 78403003 | |
Disturbance of salivary secretion | contraindication | 78948009 | |
Decreased respiratory function | contraindication | 80954004 | |
Injury of head | contraindication | 82271004 | |
Chronic idiopathic constipation | contraindication | 82934008 | |
Cor pulmonale | contraindication | 83291003 | DOID:8515 |
Hiatal hernia | contraindication | 84089009 | DOID:12642 |
Atrophic gastritis | contraindication | 84568007 | DOID:8929 |
Epilepsy | contraindication | 84757009 | DOID:1826 |
Pulmonary emphysema | contraindication | 87433001 | |
Gout | contraindication | 90560007 | DOID:13189 |
Chronic renal failure syndrome | contraindication | 90688005 | |
Kidney disease | contraindication | 90708001 | DOID:557 |
Thyrotoxicosis | contraindication | 90739004 | DOID:7997 |
Hemophilia | contraindication | 90935002 | |
Myasthenia gravis | contraindication | 91637004 | DOID:437 |
Obstruction of duodenum | contraindication | 95532008 | DOID:3558 |
Disorder of biliary tract | contraindication | 105997008 | DOID:9741 |
Anemia due to enzyme deficiency | contraindication | 111577008 | |
Prolonged QT interval | contraindication | 111975006 | |
Acute abdominal pain | contraindication | 116290004 | |
Procedure on urinary system | contraindication | 118677009 | |
Gastrointestinal obstruction | contraindication | 126765001 | |
Neoplasm of brain | contraindication | 126952004 | DOID:1319 |
von Willebrand disorder | contraindication | 128105004 | DOID:12531 |
Seizure disorder | contraindication | 128613002 | |
Autonomic dysreflexia | contraindication | 129618003 | |
Bleeding | contraindication | 131148009 | |
Prolonged PR interval | contraindication | 164947007 | |
Drug-induced psychosis | contraindication | 191483003 | DOID:1742 |
Obsessive-compulsive disorder | contraindication | 191736004 | DOID:10933 |
Insomnia | contraindication | 193462001 | |
Partial atrioventricular block | contraindication | 195039008 | |
Decompensated cardiac failure | contraindication | 195111005 | |
Acute pancreatitis | contraindication | 197456007 | DOID:2913 |
Impaired renal function disorder | contraindication | 197663003 | |
Coronary artery bypass graft | contraindication | 232717009 | |
Myocardial dysfunction | contraindication | 233928007 | |
Peripheral ischemia | contraindication | 233958001 | |
Gastroesophageal reflux disease | contraindication | 235595009 | DOID:8534 |
Gastroparesis | contraindication | 235675006 | |
Disease of liver | contraindication | 235856003 | DOID:409 |
Chronic diarrhea | contraindication | 236071009 | |
Hyporeninemic hypoaldosteronism | contraindication | 236464008 | |
Aluminum intoxication | contraindication | 236546003 | |
Bladder outflow obstruction | contraindication | 236645006 | |
Morbid obesity | contraindication | 238136002 | DOID:11981 |
Sepsis syndrome | contraindication | 238150007 | |
Pyloric obstruction | contraindication | 244815007 | |
Sleep automatism | contraindication | 247962006 | |
Raynaud's phenomenon | contraindication | 266261006 | |
Benign prostatic hyperplasia | contraindication | 266569009 | |
Retention of urine | contraindication | 267064002 | |
Anemia | contraindication | 271737000 | DOID:2355 |
Drowsy | contraindication | 271782001 | |
Exacerbation of asthma | contraindication | 281239006 | |
Cerebral ischemia | contraindication | 287731003 | |
Pregnancy, function | contraindication | 289908002 | |
Lesion of brain | contraindication | 301766008 | |
Thrombocytopenic disorder | contraindication | 302215000 | DOID:1588 |
Neutropenic disorder | contraindication | 303011007 | DOID:1227 |
Familial hyperkalemic periodic paralysis | contraindication | 304737009 | DOID:14451 |
Panic disorder | contraindication | 371631005 | DOID:594 |
Coma | contraindication | 371632003 | |
Primary adrenocortical insufficiency | contraindication | 373662000 | |
Operation on gastrointestinal tract | contraindication | 386621005 | |
Hypoxia | contraindication | 389086002 | |
Angle-closure glaucoma | contraindication | 392291006 | DOID:13550 |
Cardiovascular event risk | contraindication | 395112001 | |
Pseudomembranous enterocolitis | contraindication | 397683000 | |
Gastric ulcer | contraindication | 397825006 | DOID:10808 |
Peripheral vascular disease | contraindication | 400047006 | |
Respiratory insufficiency | contraindication | 409623005 | |
Breastfeeding (mother) | contraindication | 413712001 | |
Chronic lung disease | contraindication | 413839001 | |
Chronic myocardial ischemia | contraindication | 413844008 | DOID:3393 |
Disorder of coronary artery | contraindication | 414024009 | |
Myocardial ischemia | contraindication | 414795007 | DOID:3393 |
Myocardial infarction in recovery phase | contraindication | 418044006 | |
Central nervous system depression | contraindication | 418072004 | |
Porphyria | contraindication | 418470004 | |
Ultrarapid metabolizer due to cytochrome p450 CYP2D6 variant | contraindication | 422681000 | |
Dysfunction of sphincter of Oddi | contraindication | 430887001 | |
Fibrosis of pleura | contraindication | 442110002 | |
Congenital long QT syndrome | contraindication | 442917000 | |
Hypertensive urgency | contraindication | 443482000 | |
Acute erosive gastritis | contraindication | 444926003 | |
Smokes tobacco daily | contraindication | 449868002 | |
Severe dehydration | contraindication | 450316000 | |
Acute exacerbation of asthma | contraindication | 708038006 | |
Ergot Alkaloid Toxicity | contraindication | ||
Acute Thromboembolic Stroke | contraindication | ||
Organic Cardiac Disease | contraindication | ||
Severe Pruritus | contraindication |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 1.86 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Adenosine receptor A1 | GPCR | ANTAGONIST | Ki | 4.97 | IUPHAR | CHEMBL | |||
Adenosine receptor A2b | GPCR | ANTAGONIST | Ki | 4.77 | WOMBAT-PK | CHEMBL | |||
Adenosine receptor A2a | GPCR | ANTAGONIST | Ki | 5.61 | CHEMBL | CHEMBL | |||
Acetylcholinesterase | Enzyme | IC50 | 5.14 | CHEMBL | |||||
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform | Kinase | IC50 | 4.12 | CHEMBL | |||||
Guanine deaminase | Enzyme | Ki | 4.99 | CHEMBL | |||||
Potassium voltage-gated channel subfamily H member 2 | Ion channel | IC50 | 5.31 | CHEMBL | |||||
Adenosine receptor A3 | GPCR | ANTAGONIST | Ki | 4.33 | WOMBAT-PK | ||||
Glycogen phosphorylase, muscle form | Enzyme | IC50 | 4.13 | CHEMBL | |||||
Adenosine receptor A1 | GPCR | Ki | 4.77 | CHEMBL | |||||
Adenosine receptor A2a | GPCR | Ki | 5.03 | CHEMBL | |||||
Adenosine receptor A1 | GPCR | Ki | 4.54 | CHEMBL | |||||
Adenosine receptor A1 | GPCR | Ki | 4 | CHEMBL | |||||
Adenosine A2 receptor | GPCR | Ki | 4.57 | CHEMBL | |||||
Adenosine receptor | GPCR | Ki | 4.22 | CHEMBL | |||||
Adenosine A2a receptor | GPCR | Ki | 4.10 | CHEMBL | |||||
Adenosine receptor A2b | GPCR | ANTAGONIST | Ki | 4.89 | IUPHAR |
ID | Source |
---|---|
4017537 | VUID |
N0000145919 | NUI |
D00528 | KEGG_DRUG |
69-22-7 | SECONDARY_CAS_RN |
1886 | RXNORM |
C0006644 | UMLSCUI |
CHEBI:27732 | CHEBI |
CFF | PDB_CHEM_ID |
CHEMBL113 | ChEMBL_ID |
DB00201 | DRUGBANK_ID |
CHEMBL1200569 | ChEMBL_ID |
D002110 | MESH_DESCRIPTOR_UI |
2519 | PUBCHEM_CID |
C026189 | MESH_SUPPLEMENTAL_RECORD_UI |
407 | IUPHAR_LIGAND_ID |
3G6A5W338E | UNII |
11623 | MMSL |
17093 | MMSL |
4318 | MMSL |
4319 | MMSL |
46084 | MMSL |
4939 | MMSL |
d00801 | MMSL |
1269198007 | SNOMEDCT_US |
23068001 | SNOMEDCT_US |
255641001 | SNOMEDCT_US |
91107009 | SNOMEDCT_US |
4017537 | VANDF |
4018995 | VANDF |
000600 | NDDF |
000601 | NDDF |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Fiorinal with Codeine | HUMAN PRESCRIPTION DRUG LABEL | 4 | 0023-6010 | CAPSULE | 40 mg | ORAL | NDA | 36 sections |
Fiorinal | HUMAN PRESCRIPTION DRUG LABEL | 3 | 0023-6146 | CAPSULE | 40 mg | ORAL | NDA | 23 sections |
Butalbital, Acetaminophen, Caffeine and Codeine Phosphate | HUMAN PRESCRIPTION DRUG LABEL | 4 | 0054-0650 | CAPSULE | 40 mg | ORAL | ANDA | 33 sections |
Butalbital, Acetaminophen, Caffeine and Codeine Phosphate | HUMAN PRESCRIPTION DRUG LABEL | 4 | 0054-0650 | CAPSULE | 40 mg | ORAL | ANDA | 33 sections |
Butalbital, Acetaminophen, Caffeine and Codeine Phosphate | HUMAN PRESCRIPTION DRUG LABEL | 4 | 0054-3000 | CAPSULE | 40 mg | ORAL | ANDA | 33 sections |
Butalbital, Acetaminophen, Caffeine and Codeine Phosphate | HUMAN PRESCRIPTION DRUG LABEL | 4 | 0054-3000 | CAPSULE | 40 mg | ORAL | ANDA | 33 sections |
ExcedrinExtra Strength Pain Reliever | HUMAN OTC DRUG LABEL | 3 | 0067-2000 | TABLET, FILM COATED | 65 mg | ORAL | OTC monograph not final | 13 sections |
ExcedrinExtra Strength Pain Reliever | HUMAN OTC DRUG LABEL | 3 | 0067-2000 | TABLET, FILM COATED | 65 mg | ORAL | OTC monograph not final | 13 sections |
ExcedrinExtra Strength Pain Reliever | HUMAN OTC DRUG LABEL | 3 | 0067-2001 | TABLET, FILM COATED | 65 mg | ORAL | OTC monograph not final | 15 sections |
ExcedrinExtra Strength Pain Reliever | HUMAN OTC DRUG LABEL | 3 | 0067-2001 | TABLET, FILM COATED | 65 mg | ORAL | OTC monograph not final | 15 sections |
ExcedrinExtra Strength Geltabs | HUMAN OTC DRUG LABEL | 3 | 0067-2021 | TABLET, COATED | 65 mg | ORAL | OTC monograph not final | 14 sections |
ExcedrinMigraine Geltabs | HUMAN OTC DRUG LABEL | 3 | 0067-2035 | TABLET, COATED | 65 mg | ORAL | NDA | 14 sections |
EXCEDRINMIGRAINE | HUMAN OTC DRUG LABEL | 3 | 0067-2039 | TABLET, FILM COATED | 65 mg | ORAL | NDA | 15 sections |
EXCEDRINMIGRAINE | HUMAN OTC DRUG LABEL | 3 | 0067-2039 | TABLET, FILM COATED | 65 mg | ORAL | NDA | 15 sections |
ExcedrinMigraine | HUMAN OTC DRUG LABEL | 3 | 0067-2040 | TABLET, FILM COATED | 65 mg | ORAL | NDA | 16 sections |
ExcedrinMigraine | HUMAN OTC DRUG LABEL | 3 | 0067-2040 | TABLET, FILM COATED | 65 mg | ORAL | NDA | 16 sections |
ExcedrinTension Headache | HUMAN OTC DRUG LABEL | 2 | 0067-8139 | TABLET, FILM COATED | 65 mg | ORAL | OTC monograph not final | 15 sections |
EXCEDRINMIGRAINE | HUMAN OTC DRUG LABEL | 3 | 0067-8201 | TABLET, FILM COATED | 65 mg | ORAL | NDA | 15 sections |
EXCEDRINMIGRAINE | HUMAN OTC DRUG LABEL | 3 | 0067-8201 | TABLET, FILM COATED | 65 mg | ORAL | NDA | 15 sections |
ExcedrinExtra Strength Pain Reliever | HUMAN OTC DRUG LABEL | 3 | 0067-8202 | TABLET, FILM COATED | 65 mg | ORAL | OTC monograph not final | 15 sections |
ExcedrinExtra Strength Pain Reliever | HUMAN OTC DRUG LABEL | 3 | 0067-8202 | TABLET, FILM COATED | 65 mg | ORAL | OTC monograph not final | 15 sections |
ExcedrinExtra Strength Pain Reliever | HUMAN OTC DRUG LABEL | 3 | 0067-8203 | TABLET, FILM COATED | 65 mg | ORAL | OTC monograph not final | 15 sections |
good sense migraine formula | HUMAN OTC DRUG LABEL | 3 | 0113-0374 | TABLET, FILM COATED | 65 mg | ORAL | ANDA | 15 sections |
good sense migraine formula | HUMAN OTC DRUG LABEL | 3 | 0113-0374 | TABLET, FILM COATED | 65 mg | ORAL | ANDA | 15 sections |
good sense stay awake | HUMAN OTC DRUG LABEL | 1 | 0113-0409 | TABLET | 200 mg | ORAL | OTC monograph final | 14 sections |
good sense migraine formula | HUMAN OTC DRUG LABEL | 3 | 0113-1619 | TABLET, FILM COATED | 65 mg | ORAL | ANDA | 15 sections |
good sense headache relief | HUMAN OTC DRUG LABEL | 3 | 0113-1855 | TABLET, FILM COATED | 65 mg | ORAL | OTC monograph not final | 15 sections |
basic care migraine relief | HUMAN OTC DRUG LABEL | 3 | 0113-7374 | TABLET, FILM COATED | 65 mg | ORAL | ANDA | 15 sections |
PANADOLExtra | HUMAN OTC DRUG LABEL | 2 | 0135-0620 | TABLET, FILM COATED | 65 mg | ORAL | OTC monograph not final | 16 sections |
Butalbital, Acetaminophen, and Caffeine | HUMAN PRESCRIPTION DRUG LABEL | 3 | 0143-0170 | CAPSULE | 40 mg | ORAL | ANDA | 26 sections |