caffeine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
463 58-08-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • anhydrous caffeine
  • peyona
  • caffeine
  • 1,3,7-trimethyl-2,6-dioxopurine
  • 7-methyltheophylline
  • cafalgine
  • cafeina
  • durvitan
  • guaranine
  • thein
  • caffeine citrate
  • caffeine, citrated
  • nymusa
A methylxanthine naturally occurring in some beverages and also used as a pharmacological agent. Caffeine's most notable pharmacological effect is as a central nervous system stimulant, increasing alertness and producing agitation. It also relaxes SMOOTH MUSCLE, stimulates CARDIAC MUSCLE, stimulates DIURESIS, and appears to be useful in the treatment of some types of headache. Several cellular actions of caffeine have been observed, but it is not entirely clear how each contributes to its pharmacological profile. Among the most important are inhibition of cyclic nucleotide PHOSPHODIESTERASES, antagonism of ADENOSINE RECEPTORS, and modulation of intracellular calcium handling.
  • Molecular weight: 194.19
  • Formula: C8H10N4O2
  • CLOGP: -0.04
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 0
  • TPSA: 58.44
  • ALOGS: -1.25
  • ROTB: 0
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.40 g O
0.40 g P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 21.50 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 1 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 51.77 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 98 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 0.63 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 1.40 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.64 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 4.90 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Nov. 26, 1948 FDA NOVARTIS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 2535.06 9.89 3633 362838 142040 62980511
Toxicity to various agents 2037.71 9.89 4439 362032 242811 62879740
Infusion related reaction 718.61 9.89 3063 363408 242458 62880093
Sinusitis 527.69 9.89 2645 363826 224008 62898543
Acute hepatic failure 484.33 9.89 563 365908 17764 63104787
Muscle injury 476.89 9.89 1120 365351 64225 63058326
Overdose 474.65 9.89 1603 364868 113475 63009076
Folliculitis 473.23 9.89 1168 365303 69149 63053402
Lower respiratory tract infection 450.42 9.89 1731 364740 130576 62991975
Exposure to toxic agent 437.55 9.89 316 366155 5271 63117280
Irritable bowel syndrome 427.40 9.89 1243 365228 81169 63041382
Product dose omission issue 394.26 9.89 463 366008 233850 62888701
Blister 370.94 9.89 1609 364862 128205 62994346
Metabolic acidosis 348.05 9.89 790 365681 44279 63078272
Ill-defined disorder 318.77 9.89 1118 365353 80637 63041914
Rheumatoid arthritis 310.60 9.89 2515 363956 251304 62871247
Impaired healing 303.67 9.89 1285 365186 101257 63021294
Intentional product misuse 296.00 9.89 898 365573 60019 63062532
Sleep disorder due to general medical condition, insomnia type 292.51 9.89 810 365661 51407 63071144
Duodenal ulcer perforation 291.72 9.89 1135 365336 86074 63036477
Helicobacter infection 284.31 9.89 1175 365296 91610 63030941
Blood pressure fluctuation 282.06 9.89 741 365730 45576 63076975
Injection site pain 269.98 9.89 212 366259 129588 62992963
Anti-cyclic citrullinated peptide antibody positive 269.83 9.89 1356 365115 114856 63007695
Hepatic enzyme increased 250.72 9.89 2011 364460 200317 62922234
Joint swelling 247.97 9.89 2936 363535 324730 62797821
Pericarditis 244.57 9.89 1445 365026 130134 62992417
Nasopharyngitis 225.00 9.89 2350 364121 251907 62870644
Therapeutic product effect decreased 220.50 9.89 1885 364586 191302 62931249
Anion gap 207.74 9.89 116 366355 1201 63121350
Gastrointestinal disorder 202.15 9.89 1374 365097 129865 62992686
Stomatitis 192.45 9.89 1416 365055 137309 62985242
Body temperature increased 184.15 9.89 552 365919 36640 63085911
Diarrhoea 178.41 9.89 2982 363489 712384 62410167
Psoriasis 177.06 9.89 145 366326 86812 63035739
Hepatotoxicity 169.65 9.89 535 365936 36506 63086045
Intentional overdose 166.96 9.89 858 365613 73294 63049257
Device expulsion 161.59 9.89 10 366461 34912 63087639
Swelling 157.16 9.89 2345 364126 273033 62849518
Hypersensitivity 156.91 9.89 2466 364005 290219 62832332
Depressed level of consciousness 153.01 9.89 737 365734 61341 63061210
Respiratory arrest 151.79 9.89 474 365997 32171 63090380
Weight increased 150.83 9.89 2226 364245 258566 62863985
Discomfort 150.26 9.89 1552 364919 165822 62956729
Synovitis 146.05 9.89 1686 364785 185232 62937319
Hand deformity 142.85 9.89 1478 364993 157979 62964572
Medication error 141.55 9.89 638 365833 51646 63070905
Intentional product use issue 138.04 9.89 1233 365238 126659 62995892
Coagulopathy 134.68 9.89 338 366133 20206 63102345
Ear pain 133.07 9.89 485 365986 35633 63086918
Injection site erythema 132.70 9.89 171 366300 83003 63039548
Confusional state 132.12 9.89 2006 364465 234374 62888177
Peripheral swelling 129.23 9.89 2205 364266 263737 62858814
Wrong technique in product usage process 128.08 9.89 103 366368 62237 63060314
Cardio-respiratory arrest 126.18 9.89 681 365790 59278 63063273
Disease progression 125.08 9.89 332 366139 122426 63000125
Wound 125.00 9.89 1467 365004 161796 62960755
Rheumatoid factor positive 123 9.89 872 365599 83534 63039017
Hepatic failure 119.10 9.89 464 366007 35192 63087359
Injection site reaction 118.61 9.89 98 366373 58426 63064125
Anaemia 106.43 9.89 1131 365340 292299 62830252
Off label use 105.44 9.89 3027 363444 671435 62451116
COVID-19 104.83 9.89 320 366151 112783 63009768
Drug ineffective 104.59 9.89 4951 361520 1039814 62082737
Poisoning 102.25 9.89 237 366234 13463 63109088
Heart rate decreased 101.02 9.89 525 365946 45035 63077516
Neutropenia 100.46 9.89 595 365876 174410 62948141
Muscle spasticity 99.07 9.89 314 366157 21480 63101071
Analgesic drug level increased 98.87 9.89 93 366378 2279 63120272
Infection 98.84 9.89 1865 364606 227308 62895243
Therapeutic product effect incomplete 98.83 9.89 379 366092 124677 62997874
Creatinine renal clearance decreased 94.29 9.89 256 366215 16052 63106499
Hospitalisation 93.74 9.89 221 366250 84860 63037691
Injection site pruritus 93.36 9.89 74 366397 45042 63077509
Sedation complication 93.33 9.89 230 366241 13592 63108959
Night sweats 92.47 9.89 539 365932 48275 63074276
Hepatic necrosis 90.15 9.89 136 366335 5551 63117000
Injection site bruising 87.66 9.89 68 366403 41842 63080709
Acute lung injury 86.25 9.89 72 366399 1499 63121052
Sopor 85.23 9.89 13 366458 22151 63100400
Drug resistance 84.73 9.89 15 366456 22918 63099633
Neuropathy peripheral 82.58 9.89 356 366115 113311 63009240
Therapy cessation 81.17 9.89 37 366434 30420 63092131
Respiratory depression 81.01 9.89 217 366254 13498 63109053
Blood calcium decreased 80.96 9.89 335 366136 26116 63096435
Cardiac failure congestive 79.74 9.89 270 366201 92163 63030388
Infusion site pain 78.47 9.89 245 366226 16624 63105927
Drug hypersensitivity 77.73 9.89 1293 365178 309394 62813157
Infusion site swelling 76.21 9.89 172 366299 9598 63112953
Malignant neoplasm progression 75.62 9.89 233 366238 81888 63040663
Rheumatic fever 75.26 9.89 466 366005 42645 63079906
Exposure via ingestion 74.57 9.89 88 366383 2821 63119730
Pruritus 73.18 9.89 2661 363810 358792 62763759
Therapy interrupted 72.65 9.89 49 366422 32406 63090145
Injection site swelling 72.62 9.89 101 366370 47471 63075080
Pyroglutamate increased 69.99 9.89 39 366432 402 63122149
Myocardial infarction 69.45 9.89 318 366153 99575 63022976
Myelosuppression 69.34 9.89 25 366446 23678 63098873
No adverse event 69.31 9.89 82 366389 41323 63081228
Cognitive disorder 69.10 9.89 555 365916 55260 63067291
Drug ineffective for unapproved indication 69.07 9.89 57 366414 34006 63088545
Osteonecrosis of jaw 68.50 9.89 61 366410 35062 63087489
Suspected suicide 68.12 9.89 130 366341 6438 63116113
Cardiac failure 67.96 9.89 274 366197 88868 63033683
Glossodynia 67.15 9.89 1426 365045 177450 62945101
Oxygen saturation decreased 66.85 9.89 794 365677 87791 63034760
Respiratory disorder 64.22 9.89 416 366055 38666 63083885
Coma 64.07 9.89 610 365861 63754 63058797
Nausea 63.84 9.89 4165 362306 850306 62272245
Blood pressure diastolic abnormal 63.80 9.89 207 366264 14335 63108216
Feeling abnormal 61.71 9.89 553 365918 147839 62974712
Blood cholesterol increased 61.64 9.89 821 365650 93211 63029340
Orthostatic hypotension 60.09 9.89 386 366085 35774 63086777
Swollen joint count increased 60.00 9.89 385 366086 35669 63086882
Blood pressure increased 59.87 9.89 1289 365182 160773 62961778
Blood pressure diastolic decreased 58.42 9.89 273 366198 22433 63100118
Contusion 57.22 9.89 1199 365272 148845 62973706
Product storage error 56.99 9.89 9 366462 14947 63107604
Hepatic cytolysis 56.83 9.89 207 366264 15200 63107351
Pemphigus 56.38 9.89 1424 365047 182302 62940249
Interstitial lung disease 56.04 9.89 177 366294 61731 63060820
Surgery 55.06 9.89 76 366395 35836 63086715
Product quality issue 54.89 9.89 76 366395 35789 63086762
Arthropathy 54.88 9.89 1758 364713 233034 62889517
Infusion site erythema 54.67 9.89 170 366301 11509 63111042
White blood cell count decreased 54.56 9.89 526 365945 138578 62983973
Neoplasm progression 52.98 9.89 80 366391 36348 63086203
International normalised ratio increased 52.85 9.89 453 366018 45972 63076579
Red blood cell sedimentation rate abnormal 52.76 9.89 24 366447 19758 63102793
Dizziness 52.38 9.89 1991 364480 427934 62694617
Cerebrovascular accident 52.02 9.89 387 366084 107637 63014914
Mucosal inflammation 51.60 9.89 122 366349 46806 63075745
Contraindicated product administered 50.96 9.89 1630 364841 216018 62906533
Infusion site extravasation 50.89 9.89 154 366317 10272 63112279
Throat irritation 50.27 9.89 381 366090 37266 63085285
Electric shock 49.82 9.89 49 366422 1271 63121280
Pancytopenia 49.72 9.89 341 366130 96592 63025959
Sedation 49.18 9.89 388 366083 38421 63084130
Urticaria 49.08 9.89 1279 365192 164523 62958028
Product substitution issue 48.30 9.89 16 366455 15980 63106571
Rash pruritic 48.01 9.89 180 366291 59619 63062932
Product prescribing error 47.37 9.89 49 366422 26240 63096311
Device dislocation 47.36 9.89 47 366424 25658 63096893
Palmar-plantar erythrodysaesthesia syndrome 47.30 9.89 38 366433 22977 63099574
Cardiac arrest 47.29 9.89 774 365697 91771 63030780
Device malfunction 47.11 9.89 22 366449 17835 63104716
Injection site rash 46.87 9.89 25 366446 18784 63103767
Dyspnoea exertional 46.82 9.89 184 366287 60118 63062433
Mobility decreased 46.78 9.89 970 365501 120189 63002362
Hypotension 46.43 9.89 1970 364501 270634 62851917
Posterior reversible encephalopathy syndrome 46.33 9.89 21 366450 17324 63105227
Liver injury 45.89 9.89 543 365928 59977 63062574
Crystal urine present 45.69 9.89 52 366419 1602 63120949
Anion gap abnormal 45.65 9.89 29 366442 387 63122164
Epistaxis 45.64 9.89 240 366231 72485 63050066
Pyroglutamic acidosis 45.40 9.89 34 366437 601 63121950
Pyrexia 45.38 9.89 3225 363246 467253 62655298
Bone marrow failure 44.89 9.89 62 366409 29228 63093323
Arthralgia 44.75 9.89 3843 362628 565867 62556684
Renal impairment 44.74 9.89 312 366159 88043 63034508
Blood parathyroid hormone decreased 44.71 9.89 3 366468 9788 63112763
Injury 44.52 9.89 631 365840 72616 63049935
Injection site warmth 44.49 9.89 16 366455 15179 63107372
Drug interaction 44.27 9.89 996 365475 228135 62894416
Soft tissue disorder 43.99 9.89 86 366385 4336 63118215
Dry skin 43.89 9.89 174 366297 56713 63065838
White blood cells urine positive 43.85 9.89 94 366377 5064 63117487
Gastrooesophageal reflux disease 43.53 9.89 348 366123 95291 63027260
Heart rate irregular 43.38 9.89 249 366222 22172 63100379
Device issue 43.22 9.89 44 366427 23737 63098814
Unevaluable event 43.02 9.89 152 366319 51234 63071317
Impaired quality of life 43.01 9.89 13 366458 13770 63108781
Paraesthesia 42.97 9.89 642 365829 156324 62966227
Full blood count abnormal 42.06 9.89 74 366397 31643 63090908
Device difficult to use 41.92 9.89 11 366460 12785 63109766
Diabetes mellitus 41.62 9.89 173 366298 55637 63066914
Blood pressure systolic abnormal 40.54 9.89 169 366302 13217 63109334
Heart rate increased 40.23 9.89 766 365705 93472 63029079
Blood pressure systolic increased 39.88 9.89 434 366037 46963 63075588
Injection site mass 39.35 9.89 30 366441 18626 63103925
Rash 39.10 9.89 3751 362720 557120 62565431
Urine abnormality 38.41 9.89 108 366363 6911 63115640
Malaise 38.36 9.89 1986 364485 413968 62708583
Accidental overdose 38.22 9.89 248 366223 23061 63099490
Suicide attempt 37.91 9.89 527 365944 60391 63062160
Injection site haemorrhage 37.73 9.89 51 366420 24263 63098288
Drug abuse 37.60 9.89 608 365863 71910 63050641
Body temperature decreased 37.59 9.89 223 366248 20096 63102455
Infusion site pruritus 37.18 9.89 97 366374 5938 63116613
Lymphocyte count decreased 36.97 9.89 300 366171 29957 63092594
Substance abuse 36.80 9.89 84 366387 4723 63117828
Muscle spasms 36.68 9.89 657 365814 155493 62967058
Product use in unapproved indication 36.43 9.89 772 365699 178308 62944243
Pneumonia 36.43 9.89 2212 364259 454555 62667996
Alanine aminotransferase increased 36.28 9.89 819 365652 102951 63019600
Injection site urticaria 36.11 9.89 18 366453 14055 63108496
Disease recurrence 35.74 9.89 67 366404 27963 63094588
Full blood count decreased 35.16 9.89 60 366411 25964 63096587
Bone pain 35.03 9.89 179 366292 54462 63068089
Decreased appetite 34.78 9.89 1144 365327 249908 62872643
Fall 34.52 9.89 1882 364589 390452 62732099
Respiratory rate increased 34.31 9.89 163 366308 13485 63109066
Blood pH decreased 34.29 9.89 57 366414 2530 63120021
Administration site swelling 34.27 9.89 40 366431 1267 63121284
Dysgeusia 34.08 9.89 146 366325 46564 63075987
Urinary sediment present 33.95 9.89 52 366419 2151 63120400
Thrombocytopenia 33.93 9.89 641 365830 150516 62972035
Acute kidney injury 33.56 9.89 1213 365258 262202 62860349
Bursitis 33.43 9.89 344 366127 36697 63085854
Systemic lupus erythematosus 33.37 9.89 1500 364971 207418 62915133
Underdose 32.96 9.89 68 366403 27388 63095163
Administration site pain 32.79 9.89 32 366439 822 63121729
Myelodysplastic syndrome 32.79 9.89 29 366442 16725 63105826
Dermatitis atopic 32.55 9.89 8 366463 9716 63112835
Hyperkalaemia 32.29 9.89 182 366289 54021 63068530
Drug intolerance 32.20 9.89 2130 364341 306531 62816020
Memory impairment 31.51 9.89 418 366053 103840 63018711
Neutrophil percentage increased 31.45 9.89 59 366412 2884 63119667
Red blood cells urine positive 31.35 9.89 61 366410 3065 63119486
Illness 31.29 9.89 161 366310 48898 63073653
Oedema peripheral 30.57 9.89 846 365625 188665 62933886
Fibromyalgia 30.43 9.89 642 365829 79778 63042773
Musculoskeletal disorder 30.35 9.89 45 366426 20599 63101952
Rhinitis allergic 30.09 9.89 15 366456 11712 63110839
Abortion spontaneous 30.03 9.89 155 366316 47040 63075511
Myalgia 29.99 9.89 631 365840 145898 62976653
Angioedema 29.70 9.89 159 366312 47806 63074745
Lymphocyte percentage decreased 29.63 9.89 58 366413 2927 63119624
Burning sensation 29.61 9.89 188 366283 54219 63068332
Acidosis 29.59 9.89 136 366335 11097 63111454
Hypercalcaemia 29.28 9.89 76 366395 28246 63094305
Accidental exposure to product 28.75 9.89 73 366398 27332 63095219
Infusion site nodule 28.52 9.89 39 366432 1453 63121098
Dysphonia 28.29 9.89 160 366311 47454 63075097
Type 2 diabetes mellitus 28.24 9.89 522 365949 63346 63059205
Transient ischaemic attack 28.16 9.89 117 366354 37636 63084915
Eye pruritus 28.13 9.89 40 366431 18631 63103920
Ageusia 27.79 9.89 23 366448 13705 63108846
Brain oedema 27.70 9.89 158 366313 14037 63108514
Seizure 27.49 9.89 570 365901 132064 62990487
Therapeutic response unexpected 27.47 9.89 41 366430 18718 63103833
Deep vein thrombosis postoperative 27.29 9.89 134 366337 11235 63111316
Body temperature fluctuation 27.20 9.89 48 366423 2237 63120314
Liver transplant 27.11 9.89 48 366423 2243 63120308
Anion gap increased 27.03 9.89 43 366428 1839 63120712
Fracture 26.60 9.89 45 366426 19539 63103012
Injection site induration 26.53 9.89 10 366461 9216 63113335
Carpal tunnel syndrome 26.33 9.89 50 366421 20767 63101784
Infusion site bruising 26.12 9.89 64 366407 3768 63118783
Prothrombin time prolonged 26.09 9.89 117 366354 9447 63113104
Septic shock 26.08 9.89 252 366219 66377 63056174
Eczema 26.05 9.89 97 366374 32194 63090357
Hyponatraemia 25.89 9.89 472 365999 111428 63011123
Hypertensive crisis 25.88 9.89 30 366441 15256 63107295
Analgesic drug level above therapeutic 25.86 9.89 15 366456 168 63122383
Panniculitis 25.73 9.89 17 366454 11368 63111183
Therapeutic response decreased 25.68 9.89 229 366242 61296 63061255
Brain death 25.45 9.89 59 366412 3351 63119200
Intervertebral discitis 25.37 9.89 57 366414 3171 63119380
Red cell distribution width increased 25.24 9.89 124 366347 10400 63112151
Disturbance in attention 25.11 9.89 124 366347 38065 63084486
Anti-cyclic citrullinated peptide antibody 25.10 9.89 91 366380 6667 63115884
Neonatal hypoxia 24.77 9.89 24 366447 611 63121940
Basal cell carcinoma 24.65 9.89 81 366390 27910 63094641
Loss of personal independence in daily activities 24.56 9.89 404 366067 96886 63025665
Skin exfoliation 24.46 9.89 147 366324 42955 63079596
Vision blurred 24.45 9.89 378 366093 91546 63031005
Diabetic ketoacidosis 24.43 9.89 51 366420 20454 63102097
Lip dry 24.40 9.89 163 366308 15307 63107244
Facet joint syndrome 24.27 9.89 136 366335 12002 63110549
Cytomegalovirus infection 24.22 9.89 53 366418 20899 63101652
Respiratory tract congestion 24.20 9.89 41 366430 17791 63104760
Suicidal ideation 24.05 9.89 237 366234 62184 63060367
Haematotoxicity 24.05 9.89 12 366459 9364 63113187
Specific gravity urine decreased 24.04 9.89 26 366445 756 63121795
Skin necrosis 24.02 9.89 27 366444 13923 63108628
Pneumocystis jirovecii pneumonia 23.78 9.89 38 366433 16876 63105675
Dehydration 23.74 9.89 791 365680 172563 62949988
Pain in extremity 23.69 9.89 1621 364850 329865 62792686
Frequent bowel movements 23.63 9.89 62 366409 22960 63099591
Breast cancer female 23.62 9.89 26 366445 13533 63109018
Urine leukocyte esterase positive 23.58 9.89 59 366412 3520 63119031
Sepsis 23.56 9.89 688 365783 152435 62970116
Platelet count decreased 23.48 9.89 501 365970 115621 63006930
Blood pressure diastolic increased 23.33 9.89 117 366354 9893 63112658
Drug screen positive 23.05 9.89 59 366412 3570 63118981
Hyperlipidaemia 23.04 9.89 49 366422 19522 63103029
Visual acuity reduced 23.00 9.89 58 366413 21768 63100783
Multiple drug therapy 22.87 9.89 59 366412 3587 63118964
Renal failure neonatal 22.82 9.89 14 366457 175 63122376
Multiple sclerosis relapse 22.70 9.89 175 366296 48303 63074248
Jaundice cholestatic 22.60 9.89 93 366378 7231 63115320
Metastases to liver 22.52 9.89 66 366405 23573 63098978
Lung neoplasm malignant 22.42 9.89 50 366421 19583 63102968
Polyneuropathy 22.24 9.89 31 366440 14558 63107993
Blood creatine increased 22.15 9.89 77 366394 5524 63117027
Hypokalaemia 22.13 9.89 444 366027 103360 63019191
Aspartate aminotransferase increased 22.12 9.89 680 365791 89597 63032954
Metastases to bone 22.04 9.89 56 366415 20963 63101588
Haematochezia 22.04 9.89 200 366271 53344 63069207
Hypothermia 21.96 9.89 144 366327 13437 63109114
Coronary artery disease 21.94 9.89 104 366367 32273 63090278
Abdominal pain upper 21.93 9.89 1427 365044 205017 62917534
Depression 21.91 9.89 919 365552 195573 62926978
Taste disorder 21.87 9.89 28 366443 13634 63108917
Ductus arteriosus premature closure 21.84 9.89 17 366454 319 63122232
Joint stiffness 21.61 9.89 147 366324 41722 63080829
Palpitations 21.52 9.89 491 365980 112279 63010272
Leukopenia 21.18 9.89 316 366155 76974 63045577
Breast cancer 21.12 9.89 178 366293 48205 63074346
Iron deficiency anaemia 21.09 9.89 53 366418 19916 63102635
Genital haemorrhage 21.00 9.89 8 366463 7324 63115227
Foetal exposure during pregnancy 20.89 9.89 104 366367 31858 63090693
Hypothyroidism 20.86 9.89 152 366319 42480 63080071
Second primary malignancy 20.67 9.89 10 366461 7943 63114608
Atrial fibrillation 20.56 9.89 514 365957 116122 63006429
Complication associated with device 20.42 9.89 42 366429 16936 63105615
Cardiac disorder 20.40 9.89 191 366280 50625 63071926
Tremor 20.38 9.89 594 365877 131645 62990906
Precancerous cells present 20.36 9.89 33 366438 1434 63121117
Peripheral venous disease 20.30 9.89 156 366315 15321 63107230
Hypocalcaemia 20.26 9.89 104 366367 31609 63090942
PCO2 decreased 20.25 9.89 31 366440 1282 63121269
Swollen tongue 20.11 9.89 118 366353 34682 63087869
Blood glucose increased 20.10 9.89 351 366120 83405 63039146
Aphasia 20.09 9.89 110 366361 32890 63089661
Pathogen resistance 20.03 9.89 6 366465 6392 63116159
Bacterial test 19.94 9.89 29 366442 1145 63121406
Smear cervix abnormal 19.86 9.89 49 366422 2897 63119654
Premature delivery 19.52 9.89 99 366372 30182 63092369
Extrapyramidal disorder 19.48 9.89 29 366442 13255 63109296
Weight decreased 19.37 9.89 1356 365115 275442 62847109
Rheumatoid nodule 19.34 9.89 44 366427 17111 63105440
Hypomania 19.23 9.89 80 366391 6250 63116301
Lip swelling 19.21 9.89 103 366368 30960 63091591
Abdominal distension 19.21 9.89 368 366103 86247 63036304
Asthma 19.16 9.89 575 365896 126986 62995565
Parosmia 19.10 9.89 6 366465 6200 63116351
Hypomagnesaemia 19.07 9.89 93 366378 28644 63093907
Body height decreased 19.06 9.89 18 366453 10060 63112491
Neutrophil count decreased 18.97 9.89 221 366250 56185 63066366
Epilepsy 18.89 9.89 86 366385 26979 63095572
Neurotoxicity 18.81 9.89 44 366427 16946 63105605
Inappropriate antidiuretic hormone secretion 18.81 9.89 38 366433 15424 63107127
Hallucination, auditory 18.81 9.89 28 366443 12796 63109755
Cholecystitis chronic 18.71 9.89 113 366358 10248 63112303
Haemolysis 18.62 9.89 83 366388 6685 63115866
Procedural pain 18.59 9.89 63 366408 21506 63101045
Skin ulcer 18.50 9.89 159 366312 42886 63079665
Psoriatic arthropathy 18.46 9.89 395 366076 91125 63031426
Tinnitus 18.43 9.89 125 366346 35503 63087048
Blood creatinine decreased 18.38 9.89 72 366399 5473 63117078
Gestational diabetes 18.36 9.89 13 366458 8383 63114168
Poor venous access 18.28 9.89 147 366324 14638 63107913
Femur fracture 18.05 9.89 154 366317 41602 63080949
Labelled drug-drug interaction medication error 18.00 9.89 31 366440 13368 63109183
Haemorrhage 17.94 9.89 246 366225 60776 63061775
Syncope 17.91 9.89 528 365943 116857 63005694
Febrile bone marrow aplasia 17.87 9.89 10 366461 7315 63115236
Pulmonary hypertension 17.86 9.89 133 366338 36990 63085561
Post procedural pulmonary embolism 17.84 9.89 14 366457 266 63122285
Haemophagocytic lymphohistiocytosis 17.83 9.89 21 366450 10606 63111945
Administration site erythema 17.75 9.89 22 366449 743 63121808
Osmolar gap 17.71 9.89 10 366461 106 63122445
Unresponsive to stimuli 17.70 9.89 284 366187 33532 63089019
Complication of device removal 17.67 9.89 4 366467 5138 63117413
Blood urine present 17.65 9.89 148 366323 14921 63107630
Lupus vulgaris 17.63 9.89 75 366396 5919 63116632
Cardiomyopathy 17.56 9.89 48 366423 17536 63105015
Sensitivity to weather change 17.48 9.89 10 366461 7227 63115324
Pericardial effusion 17.32 9.89 102 366369 29956 63092595
Anaphylactic shock 17.16 9.89 74 366397 23559 63098992
Blindness 16.97 9.89 66 366405 21633 63100918
Mean cell haemoglobin concentration increased 16.93 9.89 18 366453 513 63122038
Swelling face 16.88 9.89 261 366210 63214 63059337
Product preparation error 16.87 9.89 7 366464 6085 63116466
Obstructive airways disorder 16.81 9.89 62 366409 20637 63101914
Oral discomfort 16.75 9.89 17 366454 9184 63113367
Fluid retention 16.71 9.89 243 366228 59443 63063108
Culture urine positive 16.64 9.89 53 366418 3634 63118917
Thrombosis 16.64 9.89 268 366203 64487 63058064
Nasal polyps 16.62 9.89 7 366464 6032 63116519
Renal failure 16.53 9.89 535 365936 117117 63005434
Gastrointestinal haemorrhage 16.47 9.89 350 366121 80826 63041725
Haemoglobin urine present 16.47 9.89 22 366449 801 63121750
Hepatitis cholestatic 16.46 9.89 81 366390 6797 63115754
Transplant rejection 16.34 9.89 23 366448 10757 63111794
Death 16.31 9.89 2431 364040 371950 62750601
Spinal stenosis 16.24 9.89 39 366432 14886 63107665
Pulmonary arterial hypertension 16.21 9.89 71 366400 22506 63100045
Vitamin D deficiency 16.18 9.89 35 366436 13857 63108694
Withdrawal syndrome 16.17 9.89 60 366411 19937 63102614
Eating disorder 16.08 9.89 56 366415 18960 63103591
Injection site discolouration 16.07 9.89 13 366458 7835 63114716
Cough 16.02 9.89 1463 365008 291280 62831271
Pain 16.01 9.89 4648 361823 735980 62386571
Bradypnoea 16.00 9.89 51 366420 3499 63119052
Multiple-drug resistance 15.91 9.89 5 366466 5165 63117386
Renal papillary necrosis 15.88 9.89 13 366458 263 63122288
Gout 15.82 9.89 33 366438 13238 63109313
Lactic acidosis 15.76 9.89 143 366328 38144 63084407
Electrolyte imbalance 15.74 9.89 61 366410 20015 63102536
Hyperglycaemia 15.69 9.89 160 366311 41707 63080844
Laboratory test abnormal 15.68 9.89 91 366380 26821 63095730
Nail bed inflammation 15.64 9.89 15 366456 377 63122174
Meniscus injury 15.58 9.89 11 366460 7103 63115448
Product adhesion issue 15.57 9.89 4 366467 4715 63117836
Ejection fraction decreased 15.57 9.89 71 366400 22261 63100290
Band neutrophil count increased 15.54 9.89 15 366456 380 63122171
Gait disturbance 15.46 9.89 882 365589 182296 62940255
Intentional self-injury 15.43 9.89 86 366385 25601 63096950
Osteonecrosis 15.36 9.89 81 366390 24449 63098102
Respiratory failure 15.33 9.89 459 366012 101399 63021152
Systemic infection 15.28 9.89 4 366467 4656 63117895
Pre-existing condition improved 15.27 9.89 15 366456 8229 63114322
Incorrect drug administration rate 15.27 9.89 54 366417 3908 63118643
Heavy menstrual bleeding 15.26 9.89 52 366419 17721 63104830
Post transplant lymphoproliferative disorder 15.25 9.89 5 366466 5026 63117525
Ear pruritus 15.24 9.89 54 366417 3911 63118640
Device breakage 15.24 9.89 27 366444 11515 63111036
Chronic kidney disease 15.22 9.89 178 366293 45220 63077331
Adjustment disorder with depressed mood 15.19 9.89 106 366365 10098 63112453
Product dose omission in error 15.11 9.89 13 366458 7599 63114952
Hemiplegia 15.04 9.89 19 366452 9304 63113247
Loss of consciousness 15.00 9.89 544 365927 117577 63004974
Metastases to lung 14.95 9.89 32 366439 12718 63109833
Drug tolerance 14.88 9.89 11 366460 6938 63115613
Autoimmune disorder 14.78 9.89 158 366313 17019 63105532
Hypertransaminasaemia 14.76 9.89 10 366461 6599 63115952
Rhinorrhoea 14.73 9.89 278 366193 65299 63057252
Flushing 14.70 9.89 551 365920 74536 63048015
Delirium 14.68 9.89 389 366082 50152 63072399
Gastrointestinal pain 14.67 9.89 21 366450 9755 63112796
Glycosylated haemoglobin increased 14.63 9.89 31 366440 12367 63110184
Coma hepatic 14.61 9.89 19 366452 674 63121877
Intentional dose omission 14.61 9.89 15 366456 8060 63114491
Ventricular arrhythmia 14.60 9.89 52 366419 3776 63118775
Thrombotic microangiopathy 14.59 9.89 24 366447 10537 63112014
Flatulence 14.55 9.89 129 366342 34573 63087978
Fear of injection 14.51 9.89 12 366459 7152 63115399
Pulmonary toxicity 14.50 9.89 20 366451 9435 63113116
Impaired work ability 14.42 9.89 52 366419 17423 63105128
Hepatic encephalopathy 14.40 9.89 113 366358 11169 63111382
Pain in jaw 14.40 9.89 171 366300 43325 63079226
Akathisia 14.38 9.89 19 366452 9127 63113424
Right ventricular failure 14.28 9.89 51 366420 17137 63105414
Dislocation of vertebra 14.23 9.89 92 366379 8543 63114008
Cells in urine 14.20 9.89 11 366460 205 63122346
Vitamin K deficiency 14.18 9.89 15 366456 425 63122126
Acute graft versus host disease 14.14 9.89 4 366467 4424 63118127
Ocular hyperaemia 14.14 9.89 86 366385 25058 63097493
Eosinophil percentage increased 14.08 9.89 23 366448 1006 63121545
Skin burning sensation 14.08 9.89 33 366438 12701 63109850
Toxicologic test abnormal 14.01 9.89 19 366452 702 63121849
Shoulder arthroplasty 13.98 9.89 3 366468 3999 63118552
Sleep disorder due to a general medical condition 13.95 9.89 31 366440 12157 63110394
Pulmonary mass 13.93 9.89 75 366396 22521 63100030
Administration site pruritus 13.91 9.89 13 366458 316 63122235
Cerebral haemorrhage 13.89 9.89 112 366359 30617 63091934
Immune reconstitution inflammatory syndrome 13.87 9.89 9 366462 6075 63116476
Derailment 13.86 9.89 7 366464 58 63122493
Complication of device insertion 13.74 9.89 14 366457 7550 63115001
Hepatic cirrhosis 13.70 9.89 85 366386 24649 63097902
Invasive ductal breast carcinoma 13.67 9.89 12 366459 6946 63115605
Renal disorder 13.64 9.89 123 366348 32851 63089700
Alpha 1 microglobulin increased 13.56 9.89 7 366464 61 63122490
Asphyxia 13.54 9.89 71 366400 6110 63116441
Infusion site urticaria 13.47 9.89 29 366442 1567 63120984
Ductus arteriosus stenosis foetal 13.44 9.89 10 366461 175 63122376
Pneumonia viral 13.43 9.89 85 366386 7837 63114714
Macular oedema 13.35 9.89 3 366468 3874 63118677
Speech disorder 13.35 9.89 160 366311 40469 63082082
Product physical issue 13.35 9.89 6 366465 4974 63117577
Anoxia 13.34 9.89 11 366460 225 63122326
Amenorrhoea 13.26 9.89 23 366448 9891 63112660
Drug eruption 13.24 9.89 104 366367 28590 63093961
Encephalopathy 13.23 9.89 304 366167 38316 63084235
Blood immunoglobulin E increased 13.21 9.89 3 366468 3846 63118705
Intestinal haemorrhage 13.20 9.89 3 366468 3844 63118707
Urine ketone body present 13.20 9.89 38 366433 2465 63120086
Drug abuser 13.18 9.89 42 366429 2881 63119670
Transfusion-related acute lung injury 13.16 9.89 9 366462 137 63122414
Thinking abnormal 13.08 9.89 26 366445 10617 63111934
Bone density decreased 13.06 9.89 42 366429 14570 63107981
Transaminases increased 13.05 9.89 254 366217 31113 63091438
Continuous haemodiafiltration 13.03 9.89 22 366449 989 63121562
Tardive dyskinesia 13.02 9.89 18 366453 8484 63114067
Infusion site irritation 13.01 9.89 21 366450 909 63121642
Blood bilirubin increased 12.93 9.89 293 366178 36847 63085704
Traumatic liver injury 12.86 9.89 12 366459 291 63122260
Rebound effect 12.86 9.89 5 366466 4521 63118030
Galactorrhoea 12.82 9.89 4 366467 4151 63118400
Nightmare 12.80 9.89 62 366409 19132 63103419
Hip arthroplasty 12.78 9.89 363 366108 47283 63075268
Ascites 12.77 9.89 162 366309 40566 63081985
Metastases to lymph nodes 12.77 9.89 17 366454 8141 63114410
Joint range of motion decreased 12.63 9.89 260 366211 32168 63090383
Myelocyte count increased 12.62 9.89 13 366458 357 63122194
Antidepressant drug level above therapeutic 12.52 9.89 14 366457 423 63122128
Infusion site mass 12.49 9.89 33 366438 2035 63120516
Blood uric acid decreased 12.48 9.89 19 366452 782 63121769
Foot operation 12.45 9.89 14 366457 7217 63115334
Wound infection 12.43 9.89 183 366288 21227 63101324
Epstein-Barr virus infection 12.37 9.89 17 366454 8033 63114518
Urinary tract infection 12.36 9.89 1338 365133 263346 62859205
Diaphragmatic rupture 12.34 9.89 11 366460 251 63122300
Base excess 12.33 9.89 7 366464 75 63122476
Sinus disorder 12.28 9.89 87 366384 24466 63098085
Infusion site haemorrhage 12.25 9.89 60 366411 5026 63117525
Uterine cancer 12.23 9.89 6 366465 4727 63117824
Hunger 12.20 9.89 8 366463 5371 63117180
Papule 12.20 9.89 9 366462 5682 63116869
Balance disorder 12.15 9.89 600 365871 83822 63038729
Skin toxicity 12.14 9.89 6 366465 4708 63117843
Mood swings 12.14 9.89 59 366412 18189 63104362
Skin haemorrhage 12.11 9.89 25 366446 10069 63112482
Neoplasm malignant 12.09 9.89 112 366359 29749 63092802
Pregnancy with contraceptive device 12.05 9.89 6 366465 4688 63117863
Hepatitis acute 12.01 9.89 92 366379 9028 63113523
Dyslipidaemia 11.99 9.89 15 366456 7378 63115173
Urine analysis abnormal 11.95 9.89 59 366412 4957 63117594
Coagulation factor X level decreased 11.95 9.89 7 366464 80 63122471
Acute myocardial infarction 11.94 9.89 123 366348 32001 63090550
Endophthalmitis 11.94 9.89 3 366468 3589 63118962
Device leakage 11.93 9.89 14 366457 7082 63115469
Cardiac failure acute 11.93 9.89 23 366448 9500 63113051
Angina unstable 11.93 9.89 14 366457 7081 63115470
Intermenstrual bleeding 11.92 9.89 17 366454 7909 63114642
Anxiety 11.91 9.89 1087 365384 216454 62906097
Treatment noncompliance 11.88 9.89 148 366323 37177 63085374
Hypercholesterolaemia 11.86 9.89 181 366290 21153 63101398
Erysipelas 11.85 9.89 17 366454 7888 63114663
Abnormal dreams 11.83 9.89 27 366444 10489 63112062
Autonomic dysreflexia 11.81 9.89 12 366459 324 63122227
Febrile neutropenia 11.76 9.89 561 365910 117888 63004663
Ankylosing spondylitis 11.69 9.89 27 366444 10447 63112104
Dyspnoea 11.68 9.89 3524 362947 657789 62464762
Vertigo 11.63 9.89 260 366211 59627 63062924
Diffuse large B-cell lymphoma 11.55 9.89 13 366458 6699 63115852
Insurance issue 11.50 9.89 11 366460 6110 63116441
Metastases to central nervous system 11.49 9.89 38 366433 13067 63109484
Sleep apnoea syndrome 11.48 9.89 110 366361 29023 63093528
Lumbar vertebral fracture 11.44 9.89 10 366461 5800 63116751
Transplant dysfunction 11.39 9.89 7 366464 4865 63117686
Rheumatoid lung 11.36 9.89 4 366467 3844 63118707
Accident at home 11.34 9.89 9 366462 174 63122377
Therapy change 11.34 9.89 11 366460 6070 63116481
Infective pulmonary exacerbation of cystic fibrosis 11.31 9.89 21 366450 8796 63113755
Low density lipoprotein increased 11.28 9.89 12 366459 6345 63116206
Product monitoring error 11.25 9.89 6 366465 4510 63118041
Dysphagia 11.24 9.89 408 366063 88177 63034374
Product administration interrupted 11.23 9.89 7 366464 4829 63117722
Metastases to peritoneum 11.20 9.89 3 366468 3439 63119112
Administration site extravasation 11.14 9.89 20 366451 945 63121606
Colitis 11.12 9.89 205 366266 48323 63074228
Activated partial thromboplastin time prolonged 11.09 9.89 73 366398 6820 63115731
Polycystic ovaries 11.06 9.89 6 366465 4465 63118086
Coagulation factor VII level decreased 11.05 9.89 7 366464 93 63122458
Intervertebral disc degeneration 10.97 9.89 50 366421 15682 63106869
Eye irritation 10.91 9.89 78 366393 21893 63100658
Atypical femur fracture 10.88 9.89 9 366462 5363 63117188
Band neutrophil percentage increased 10.87 9.89 10 366461 238 63122313
Excessive skin 10.85 9.89 8 366463 138 63122413
Corneal reflex decreased 10.80 9.89 8 366463 139 63122412
Maternal exposure timing unspecified 10.77 9.89 74 366397 7013 63115538
Drug-induced liver injury 10.67 9.89 306 366165 39916 63082635
C-reactive protein 10.64 9.89 56 366415 4826 63117725
Administration site reaction 10.63 9.89 10 366461 245 63122306
Cytopenia 10.61 9.89 33 366438 11568 63110983
Chronic obstructive pulmonary disease 10.57 9.89 278 366193 62408 63060143
Urinary casts 10.50 9.89 17 366454 738 63121813
Mental impairment 10.46 9.89 44 366427 14107 63108444
Delusion 10.43 9.89 35 366436 11982 63110569
Accidental death 10.42 9.89 30 366441 1946 63120605
Uterine perforation 10.41 9.89 15 366456 6948 63115603
Urine oxalate increased 10.40 9.89 10 366461 252 63122299
Partial seizures 10.40 9.89 11 366460 5831 63116720
Dry eye 10.37 9.89 169 366302 40592 63081959
Bacterial test positive 10.31 9.89 59 366412 5248 63117303
Blood methaemoglobin present 10.28 9.89 6 366465 68 63122483
Cytomegalovirus infection reactivation 10.27 9.89 5 366466 3958 63118593
Cardiogenic shock 10.26 9.89 61 366410 17871 63104680
Eye haemorrhage 10.23 9.89 21 366450 8475 63114076
Gastroenteritis 10.22 9.89 101 366370 26489 63096062
Hysterectomy 10.20 9.89 25 366446 9474 63113077
Blood lactic acid increased 10.19 9.89 73 366398 7013 63115538
Sleep disorder 10.18 9.89 572 365899 80994 63041557
Extra dose administered 10.18 9.89 13 366458 6337 63116214
Acute respiratory failure 10.14 9.89 139 366332 34346 63088205
Organising pneumonia 10.14 9.89 11 366460 5765 63116786
Dermatitis 10.07 9.89 57 366414 16901 63105650
Anosmia 10.04 9.89 15 366456 6845 63115706
Device deployment issue 10.00 9.89 5 366466 3897 63118654
Glucose tolerance impaired 10.00 9.89 14 366457 6563 63115988
Acute myeloid leukaemia 9.98 9.89 58 366413 17089 63105462
Appendix disorder 9.96 9.89 25 366446 1494 63121057
Gallbladder injury 9.95 9.89 24 366447 1399 63121152
Pleural effusion 9.95 9.89 438 366033 92772 63029779
Osmolar gap abnormal 9.94 9.89 5 366466 41 63122510
Pancreatic carcinoma 9.93 9.89 18 366453 7610 63114941
Temperature regulation disorder 9.90 9.89 65 366406 6067 63116484

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 1408.85 10.18 1840 137350 96328 34721413
Toxicity to various agents 1196.28 10.18 2528 136662 197834 34619907
Infusion related reaction 424.04 10.18 759 138431 52298 34765443
Overdose 405.40 10.18 1026 138164 90033 34727708
Blood pressure fluctuation 319.42 10.18 446 138744 24803 34792938
Acute hepatic failure 273.11 10.18 308 138882 13766 34803975
Exposure to toxic agent 261.65 10.18 170 139020 3505 34814236
Drug ineffective 245.41 10.18 964 138226 455787 34361954
Intentional product misuse 220.76 10.18 531 138659 45080 34772661
Intentional overdose 200.24 10.18 498 138692 43176 34774565
Heart rate decreased 132.03 10.18 349 138841 31396 34786345
Metabolic acidosis 125.32 10.18 421 138769 43259 34774482
Blood pressure increased 115.35 10.18 671 138519 87431 34730310
Cardio-respiratory arrest 111.51 10.18 476 138714 54797 34762944
Product dose omission issue 109.46 10.18 193 138997 119518 34698223
Respiratory arrest 104.35 10.18 296 138894 27747 34789994
Coagulopathy 98.50 10.18 233 138957 19556 34798185
Oxygen saturation decreased 89.59 10.18 438 138752 53380 34764361
Hepatotoxicity 86.08 10.18 233 138957 21252 34796489
Anion gap 84.45 10.18 49 139141 818 34816923
Accidental overdose 77.29 10.18 215 138975 19925 34797816
Substance abuse 75.12 10.18 120 139070 7521 34810220
Diarrhoea 74.94 10.18 1098 138092 388814 34428927
Hepatic necrosis 70.15 10.18 81 139109 3713 34814028
Hypotension 68.14 10.18 1250 137940 220399 34597342
Neonatal hypoxia 68.08 10.18 33 139157 374 34817367
Drug resistance 63.33 10.18 13 139177 25914 34791827
Alanine aminotransferase increased 63.07 10.18 543 138647 80272 34737469
Chills 62.45 10.18 543 138647 80500 34737241
Treatment failure 60.43 10.18 58 139132 46639 34771102
Myocardial infarction 59.30 10.18 264 138926 120821 34696920
Respiratory depression 58.03 10.18 169 139021 16076 34801665
Suspected suicide 57.24 10.18 82 139108 4666 34813075
Heart rate irregular 57.00 10.18 165 139025 15642 34802099
Sinusitis 56.52 10.18 319 138871 41083 34776658
Liver injury 54.32 10.18 156 139034 14722 34803019
Product use in unapproved indication 52.37 10.18 265 138925 117234 34700507
Cardiac failure congestive 52.22 10.18 164 139026 83106 34734635
Aspartate aminotransferase increased 52.13 10.18 454 138736 67329 34750412
Hepatic cytolysis 51.97 10.18 151 139039 14345 34803396
Medication error 46.85 10.18 214 138976 25351 34792390
Therapeutic product effect incomplete 43.90 10.18 84 139106 50457 34767284
Cardiac arrest 43.90 10.18 580 138610 95579 34722162
Disease progression 42.53 10.18 254 138936 107823 34709918
Poisoning 42.53 10.18 126 139064 12100 34805641
International normalised ratio increased 42.30 10.18 328 138862 46999 34770742
Heart rate increased 41.87 10.18 322 138868 46021 34771720
Exposure via ingestion 41.06 10.18 47 139143 2134 34815607
Blood pressure systolic increased 39.03 10.18 188 139002 22764 34794977
Depressed level of consciousness 37.23 10.18 295 138895 42546 34775195
Drug abuse 36.59 10.18 576 138614 98520 34719221
Toxic epidermal necrolysis 36.59 10.18 177 139013 21469 34796272
Suicide attempt 36.58 10.18 274 138916 38842 34778899
Analgesic drug level increased 36.50 10.18 29 139161 827 34816914
Hepatic failure 36.41 10.18 249 138941 34282 34783459
Cardiac failure 36.13 10.18 214 138976 91034 34726707
Unresponsive to stimuli 36.04 10.18 210 138980 27359 34790382
Psoriasis 35.95 10.18 62 139128 38750 34778991
Neuropathy peripheral 35.83 10.18 190 139000 83073 34734668
Stevens-Johnson syndrome 35.63 10.18 158 139032 18481 34799260
Neutrophil percentage increased 35.35 10.18 40 139150 1793 34815948
Drug ineffective for unapproved indication 34.91 10.18 26 139164 23689 34794052
Infusion site extravasation 34.45 10.18 62 139128 4282 34813459
Intentional product use issue 34.38 10.18 377 138813 59439 34758302
Pulmonary oedema 34.29 10.18 314 138876 47215 34770526
Body temperature decreased 34.19 10.18 122 139068 12912 34804829
Pyrexia 33.42 10.18 1633 137557 331380 34486361
Blood pressure diastolic increased 32.79 10.18 66 139124 4959 34812782
Product prescribing error 32.65 10.18 26 139164 22901 34794840
Blood pressure diastolic abnormal 32.30 10.18 64 139126 4754 34812987
Contraindicated product administered 31.05 10.18 24 139166 21457 34796284
Pyroglutamic acidosis 31.04 10.18 20 139170 406 34817335
Renal cortical necrosis 30.82 10.18 16 139174 212 34817529
Blood pH decreased 30.65 10.18 42 139148 2292 34815449
Tachycardia 30.63 10.18 491 138699 84281 34733460
Infusion site pain 30.59 10.18 55 139135 3796 34813945
Injection site pain 30.36 10.18 69 139121 38936 34778805
Hospitalisation 30.34 10.18 120 139070 56782 34760959
Blood pressure diastolic decreased 30.01 10.18 92 139098 9002 34808739
Prostate cancer 29.37 10.18 72 139118 39577 34778164
Rheumatoid arthritis 29.32 10.18 256 138934 37982 34779759
Myocardial fibrosis 28.14 10.18 29 139161 1168 34816573
Urticaria 27.93 10.18 375 138815 62002 34755739
Off label use 27.55 10.18 1378 137812 418146 34399595
Lymphocyte percentage decreased 27.45 10.18 38 139152 2094 34815647
Memory impairment 27.36 10.18 85 139105 43233 34774508
Prothrombin time prolonged 27.25 10.18 91 139099 9315 34808426
Myelosuppression 26.02 10.18 23 139167 19242 34798499
Sopor 25.94 10.18 8 139182 12128 34805613
Body temperature increased 25.83 10.18 137 139053 17231 34800510
Infusion site swelling 25.31 10.18 40 139150 2484 34815257
Anaemia 25.17 10.18 722 138468 232613 34585128
Urine sodium decreased 25.06 10.18 13 139177 172 34817569
Body temperature fluctuation 24.98 10.18 32 139158 1635 34816106
Aplastic anaemia 24.68 10.18 90 139100 9626 34808115
Wrong technique in product usage process 24.62 10.18 68 139122 35918 34781823
Respiratory rate increased 24.59 10.18 91 139099 9803 34807938
Malignant neoplasm progression 24.11 10.18 229 138961 87817 34729924
Bladder cancer 23.76 10.18 18 139172 16260 34801481
Coma 23.59 10.18 282 138908 45396 34772345
Glycosylated haemoglobin increased 23.38 10.18 8 139182 11352 34806389
Coronary artery disease 23.21 10.18 106 139084 48199 34769542
Psoriatic arthropathy 22.91 10.18 27 139163 19771 34797970
Pulmonary congestion 22.86 10.18 112 139078 13653 34804088
Acute lung injury 22.65 10.18 29 139161 1481 34816260
Dizziness 22.35 10.18 681 138509 217840 34599901
Cerebral artery thrombosis 22.24 10.18 21 139169 759 34816982
Methaemoglobinaemia 22.14 10.18 46 139144 3535 34814206
Full blood count abnormal 22.10 10.18 25 139165 18643 34799098
Maternal exposure before pregnancy 21.99 10.18 21 139169 770 34816971
Brain scan abnormal 21.92 10.18 22 139168 858 34816883
Therapeutic response shortened 21.78 10.18 72 139118 7332 34810409
Fatigue 21.57 10.18 1232 137958 369421 34448320
Blood pressure systolic abnormal 21.31 10.18 48 139142 3900 34813841
Flushing 21.30 10.18 210 138980 32210 34785531
Diabetes mellitus 21.26 10.18 105 139085 46768 34770973
Mental status changes 20.95 10.18 238 138952 37845 34779896
Ductus arteriosus premature closure 20.88 10.18 13 139177 248 34817493
Abdominal pain 20.46 10.18 821 138369 162797 34654944
Acidosis 20.33 10.18 92 139098 10853 34806888
Progressive multifocal leukoencephalopathy 19.88 10.18 7 139183 9757 34807984
Brain oedema 19.86 10.18 108 139082 13713 34804028
Haemolysis 19.75 10.18 74 139116 8020 34809721
Depression 19.73 10.18 270 138920 96828 34720913
Brain death 19.65 10.18 37 139153 2646 34815095
Loss of personal independence in daily activities 19.64 10.18 67 139123 33112 34784629
Adrenergic syndrome 19.29 10.18 9 139181 93 34817648
No adverse event 19.13 10.18 39 139151 22888 34794853
Asthma 19.09 10.18 96 139094 42560 34775181
Asthenia 18.77 10.18 792 138398 244459 34573282
Throat tightness 18.42 10.18 74 139116 8284 34809457
Oesophageal carcinoma 18.39 10.18 7 139183 9297 34808444
Haematotoxicity 18.25 10.18 5 139185 8189 34809552
Interstitial lung disease 18.21 10.18 169 139021 65113 34752628
Renal impairment 18.08 10.18 266 138924 94247 34723494
Chronic gastrointestinal bleeding 17.97 10.18 13 139177 321 34817420
Granulomatosis with polyangiitis 17.85 10.18 23 139167 1182 34816559
Therapy partial responder 17.77 10.18 8 139182 9608 34808133
Transaminases increased 17.74 10.18 174 139016 26649 34791092
Therapy interrupted 17.73 10.18 17 139173 13680 34804061
Infusion site pruritus 17.67 10.18 19 139171 804 34816937
Ear infection 17.53 10.18 84 139106 10147 34807594
Feeling abnormal 17.51 10.18 164 139026 63071 34754670
Renal papillary necrosis 17.50 10.18 10 139180 162 34817579
Urethral valves 17.40 10.18 12 139178 274 34817467
Bone marrow failure 17.36 10.18 59 139131 29194 34788547
General physical health deterioration 17.27 10.18 384 138806 127885 34689856
Nasopharyngitis 17.22 10.18 382 138808 69586 34748155
Inadequate analgesia 16.99 10.18 37 139153 2938 34814803
Lung neoplasm malignant 16.83 10.18 27 139163 17368 34800373
Sleep disorder 16.78 10.18 67 139123 31621 34786120
Febrile neutropenia 16.71 10.18 685 138505 136164 34681577
Mucosal inflammation 16.68 10.18 88 139102 38534 34779207
Visual acuity reduced 16.66 10.18 24 139166 16125 34801616
Immune reconstitution inflammatory syndrome 16.64 10.18 7 139183 8752 34808989
Dependent personality disorder 16.63 10.18 8 139182 89 34817652
Oxygen saturation abnormal 16.39 10.18 25 139165 1505 34816236
Visual impairment 16.35 10.18 80 139110 35722 34782019
Anion gap abnormal 16.29 10.18 10 139180 186 34817555
Balance disorder 16.26 10.18 95 139095 40559 34777182
Accidental death 15.72 10.18 32 139158 2424 34815317
Labelled drug-drug interaction medication error 15.61 10.18 22 139168 14917 34802824
Therapeutic response decreased 15.51 10.18 62 139128 29251 34788490
Cerebral haemorrhage 15.42 10.18 79 139111 34858 34782883
Bilirubin urine present 15.32 10.18 9 139181 154 34817587
Monocyte percentage increased 15.15 10.18 19 139171 950 34816791
Administration site erythema 15.03 10.18 7 139183 72 34817669
Graft versus host disease 15.03 10.18 12 139178 10557 34807184
C-reactive protein abnormal 14.95 10.18 8 139182 8702 34809039
Environmental exposure 14.88 10.18 11 139179 281 34817460
Failure to suspend medication 14.86 10.18 13 139177 425 34817316
Fluid retention 14.78 10.18 56 139134 26831 34790910
Blood triglycerides increased 14.64 10.18 21 139169 14138 34803603
Cerebral infarction 14.57 10.18 58 139132 27397 34790344
Post transplant lymphoproliferative disorder 14.51 10.18 4 139186 6524 34811217
Infusion site rash 14.49 10.18 14 139176 521 34817220
Osteonecrosis of jaw 14.45 10.18 31 139159 17858 34799883
Anti-erythrocyte antibody positive 14.30 10.18 6 139184 47 34817694
Venoocclusive liver disease 14.14 10.18 7 139183 7959 34809782
Injection site swelling 14.13 10.18 15 139175 11512 34806229
Therapeutic product effect decreased 14.00 10.18 81 139109 34662 34783079
Apnoea 13.89 10.18 58 139132 6606 34811135
Cardiac failure chronic 13.87 10.18 7 139183 7872 34809869
Pemphigus 13.87 10.18 24 139166 1607 34816134
Alopecia 13.86 10.18 50 139140 24305 34793436
Dyspnoea 13.86 10.18 1302 137888 375480 34442261
Oedema peripheral 13.85 10.18 367 138823 119445 34698296
Drug interaction 13.84 10.18 747 138443 225199 34592542
Delirium 13.77 10.18 249 138941 43742 34773999
Peripheral swelling 13.75 10.18 218 138972 76323 34741418
Haematocrit decreased 13.73 10.18 192 138998 32024 34785717
Crohn's disease 13.70 10.18 35 139155 3082 34814659
Agitation 13.69 10.18 312 138878 57087 34760654
Dry skin 13.67 10.18 71 139119 31216 34786525
Pallor 13.46 10.18 158 139032 25322 34792419
Acid-base balance disorder mixed 13.30 10.18 6 139184 57 34817684
Blood pressure decreased 13.23 10.18 283 138907 51232 34766509
Pathogen resistance 13.19 10.18 11 139179 9471 34808270
Drug screen positive 13.11 10.18 40 139150 3903 34813838
Myopathy 13.11 10.18 16 139174 11538 34806203
Endocardial fibrosis 13.04 10.18 5 139185 30 34817711
Prescribed overdose 12.89 10.18 14 139176 10633 34807108
Therapy non-responder 12.87 10.18 97 139093 39049 34778692
Cerebrovascular accident 12.86 10.18 249 138941 84562 34733179
Throat irritation 12.79 10.18 79 139111 10506 34807235
Liver transplant 12.78 10.18 30 139160 2504 34815237
Bacterial test 12.70 10.18 8 139182 156 34817585
Angina pectoris 12.70 10.18 73 139117 31290 34786451
Hallucinations, mixed 12.66 10.18 31 139159 2658 34815083
Pyroglutamate increased 12.59 10.18 10 139180 285 34817456
COVID-19 12.59 10.18 225 138965 77325 34740416
Decreased appetite 12.57 10.18 538 138652 165854 34651887
Anion gap increased 12.49 10.18 25 139165 1871 34815870
Ammonia increased 12.42 10.18 42 139148 4327 34813414
Dermatitis atopic 12.41 10.18 3 139187 5344 34812397
Blood uric acid increased 12.39 10.18 12 139178 9612 34808129
Obstructive airways disorder 12.39 10.18 27 139163 15467 34802274
Poor venous access 12.32 10.18 47 139143 5136 34812605
Urobilinogen urine increased 12.29 10.18 11 139179 371 34817370
Administration site pain 12.27 10.18 10 139180 296 34817445
Areflexia 12.27 10.18 33 139157 2998 34814743
Tendonitis 12.23 10.18 11 139179 9129 34808612
Prostatic specific antigen increased 12.22 10.18 25 139165 14655 34803086
Mydriasis 12.10 10.18 59 139131 7178 34810563
Cytopenia 12.08 10.18 20 139170 12703 34805038
Necrotising oesophagitis 12.04 10.18 13 139177 553 34817188
Adverse event 11.95 10.18 37 139153 18840 34798901
Infusion site nodule 11.90 10.18 7 139183 120 34817621
Hyperlipidaemia 11.88 10.18 25 139165 14504 34803237
Chronic obstructive pulmonary disease 11.83 10.18 131 139059 48787 34768954
Blood cholesterol increased 11.81 10.18 42 139148 20501 34797240
Ultrasound liver abnormal 11.80 10.18 7 139183 122 34817619
Bronchial dysplasia 11.72 10.18 5 139185 41 34817700
Vomiting 11.68 10.18 1141 138049 246480 34571261
Hepatitis fulminant 11.66 10.18 40 139150 4150 34813591
Injection site haemorrhage 11.65 10.18 13 139177 9755 34807986
Crystal urine present 11.65 10.18 12 139178 483 34817258
Leukopenia 11.64 10.18 178 139012 62678 34755063
Urine abnormality 11.57 10.18 25 139165 1974 34815767
Infusion site erythema 11.56 10.18 27 139163 2246 34815495
Respiratory distress 11.56 10.18 203 138987 35462 34782279
Vessel puncture site bruise 11.51 10.18 5 139185 43 34817698
Adverse drug reaction 11.50 10.18 69 139121 29273 34788468
Cardiac disorder 11.44 10.18 113 139077 43013 34774728
Foetal exposure during pregnancy 11.34 10.18 97 139093 38004 34779737
Abdominal discomfort 11.23 10.18 169 139021 59666 34758075
Protein urine 11.20 10.18 16 139174 908 34816833
Hypoxia 11.19 10.18 293 138897 54802 34762939
Specific gravity urine decreased 10.90 10.18 6 139184 90 34817651
Leukocytosis 10.90 10.18 145 139045 23920 34793821
Erythema multiforme 10.73 10.18 65 139125 8584 34809157
Parkinsonism 10.65 10.18 10 139180 8128 34809613
Cytomegalovirus infection 10.49 10.18 61 139129 26074 34791667
Hypomagnesaemia 10.46 10.18 48 139142 21803 34795938
Urine analysis abnormal 10.43 10.18 24 139166 1977 34815764
Ureteric obstruction 10.35 10.18 18 139172 1210 34816531
Acute myocardial infarction 10.33 10.18 151 139039 53568 34764173
Gait disturbance 10.31 10.18 259 138931 84881 34732860
Lethargy 10.26 10.18 225 138965 40897 34776844
Infusion site haemorrhage 10.19 10.18 16 139174 988 34816753

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 4226.50 9.63 5729 403582 240038 79095039
Toxicity to various agents 3073.47 9.63 6710 402601 414830 78920247
Infusion related reaction 952.71 9.63 2970 406341 227267 79107810
Overdose 801.58 9.63 2419 406892 181787 79153290
Acute hepatic failure 738.78 9.63 841 408470 29272 79305805
Exposure to toxic agent 687.17 9.63 482 408829 8676 79326401
Intentional product misuse 592.38 9.63 1427 407884 93738 79241339
Blood pressure fluctuation 588.46 9.63 1156 408155 65989 79269088
Rheumatoid arthritis 423.09 9.63 2152 407159 206318 79128759
Metabolic acidosis 404.91 9.63 1132 408179 81397 79253680
Intentional overdose 397.69 9.63 1323 407988 104637 79230440
Product dose omission issue 384.31 9.63 422 408889 247115 79087962
Anion gap 274.12 9.63 159 409152 2022 79333055
Hepatotoxicity 269.38 9.63 722 408589 50630 79284447
Duodenal ulcer perforation 265.73 9.63 846 408465 65365 79269712
Muscle injury 263.08 9.63 691 408620 47870 79287207
Folliculitis 250.61 9.63 738 408573 54642 79280435
Respiratory arrest 250.09 9.63 756 408555 56794 79278283
Cardio-respiratory arrest 245.54 9.63 1156 408155 107354 79227723
Anti-cyclic citrullinated peptide antibody positive 245.40 9.63 960 408351 82183 79252894
Irritable bowel syndrome 243.17 9.63 788 408523 61453 79273624
Helicobacter infection 241.87 9.63 848 408463 68856 79266221
Heart rate decreased 238.45 9.63 849 408462 69467 79265610
Hepatic enzyme increased 233.67 9.63 1672 407639 180938 79154139
Sinusitis 231.90 9.63 1758 407553 193743 79141334
Injection site pain 228.39 9.63 198 409113 129640 79205437
Sleep disorder due to general medical condition, insomnia type 220.04 9.63 604 408707 42952 79292125
Lower respiratory tract infection 218.71 9.63 1270 408041 127950 79207127
Coagulopathy 218.63 9.63 535 408776 35471 79299606
Pemphigus 198.97 9.63 1024 408287 98558 79236519
Hand deformity 197.59 9.63 1054 408257 102865 79232212
Blood pressure increased 192.34 9.63 1791 407520 209569 79125508
Diarrhoea 189.93 9.63 3280 406031 877209 78457868
Pericarditis 188.59 9.63 1043 408268 103193 79231884
Medication error 187.70 9.63 774 408537 67868 79267209
Hepatic necrosis 185.00 9.63 231 409080 8869 79326208
Depressed level of consciousness 184.92 9.63 982 408329 95670 79239407
Blister 177.93 9.63 1136 408175 118340 79216737
Nasopharyngitis 171.84 9.63 2026 407285 251855 79083222
Wound 171.37 9.63 1102 408209 115077 79220000
Glossodynia 168.62 9.63 1006 408305 102331 79232746
Anaemia 167.98 9.63 1468 407843 443547 78891530
Drug ineffective 158.63 9.63 4283 405028 1076630 78258447
Ill-defined disorder 155.75 9.63 711 408600 65164 79269913
Discomfort 155.32 9.63 1141 408170 124476 79210601
Impaired healing 154.50 9.63 871 408440 86784 79248293
Liver injury 145.15 9.63 626 408685 55988 79279089
Oxygen saturation decreased 144.35 9.63 1145 408166 127902 79207175
Myocardial infarction 144.27 9.63 474 408837 183655 79151422
Poisoning 143.43 9.63 366 408945 24906 79310171
Systemic lupus erythematosus 139.96 9.63 1083 408228 120066 79215011
Drug resistance 137.73 9.63 25 409286 42188 79292889
Body temperature increased 134.37 9.63 517 408794 43903 79291174
Psoriasis 133.16 9.63 158 409153 89429 79245648
Joint swelling 131.59 9.63 2147 407164 286499 79048578
Respiratory depression 131.53 9.63 375 408936 27255 79307822
Analgesic drug level increased 127.88 9.63 116 409195 3062 79332015
Injection site erythema 127.18 9.63 128 409183 78069 79257008
Intentional product use issue 126.97 9.63 1266 408045 150846 79184231
Hepatic failure 126.12 9.63 635 408676 60577 79274500
Disease progression 125.02 9.63 504 408807 183858 79151219
Cardiac failure congestive 122.63 9.63 351 408960 142051 79193026
Sopor 118.10 9.63 15 409296 32995 79302082
Suspected suicide 117.75 9.63 202 409109 10374 79324703
COVID-19 117.32 9.63 415 408896 157259 79177818
Cardiac failure 116.92 9.63 405 408906 154437 79180640
Synovitis 116.04 9.63 1234 408077 149500 79185577
Weight increased 114.68 9.63 2031 407280 275355 79059722
Therapeutic product effect decreased 112.70 9.63 1312 407999 162551 79172526
Exposure via ingestion 109.46 9.63 134 409177 5040 79330037
Death 108.45 9.63 3734 405577 562780 78772297
Substance abuse 108.05 9.63 194 409117 10332 79324745
Wrong technique in product usage process 106.92 9.63 133 409178 73742 79261335
Creatinine renal clearance decreased 106.60 9.63 274 409037 18728 79316349
Sedation complication 106.15 9.63 243 409068 15426 79319651
Neutropenia 104.94 9.63 957 408354 286753 79048324
Blood calcium decreased 104.27 9.63 380 408931 31439 79303638
Accidental overdose 103.25 9.63 440 408871 39141 79295936
Device expulsion 102.29 9.63 8 409303 25853 79309224
Drug ineffective for unapproved indication 101.72 9.63 69 409242 51169 79283908
Heart rate irregular 100.19 9.63 382 408929 32297 79302780
Hypotension 99.81 9.63 2962 406349 437355 78897722
Drug interaction 99.60 9.63 1515 407796 413668 78921409
Therapeutic product effect incomplete 99.34 9.63 382 408929 141263 79193814
Swelling 99.09 9.63 1613 407698 215098 79119979
Blood pressure diastolic abnormal 98.68 9.63 268 409043 18934 79316143
Arthropathy 97.96 9.63 1362 407949 175749 79159328
Off label use 97.82 9.63 3740 405571 903475 78431602
Product use in unapproved indication 96.93 9.63 820 408491 249539 79085538
Acute lung injury 96.08 9.63 98 409213 3002 79332075
Blood pressure diastolic decreased 94.95 9.63 356 408955 29860 79305217
Heart rate increased 93.68 9.63 990 408321 119734 79215343
Myelosuppression 93.23 9.63 45 409266 40251 79294826
Injection site pruritus 87.95 9.63 54 409257 42229 79292848
Injection site reaction 86.45 9.63 92 409219 54693 79280384
Interstitial lung disease 85.33 9.63 294 409017 112306 79222771
Gastrointestinal disorder 85.13 9.63 981 408330 121224 79213853
Product prescribing error 84.18 9.63 64 409247 44749 79290328
Coma 84.10 9.63 838 408473 99811 79235266
Rheumatoid factor positive 82.97 9.63 559 408752 59280 79275797
Throat irritation 82.40 9.63 422 408889 40524 79294553
Osteonecrosis of jaw 82.14 9.63 61 409250 43165 79291912
Injection site swelling 81.49 9.63 73 409238 47059 79288018
Blood pressure systolic increased 80.79 9.63 605 408706 66381 79268696
Malignant neoplasm progression 79.37 9.63 393 408918 135597 79199480
Ear pain 79.35 9.63 357 408954 32512 79302565
Bone marrow failure 79.34 9.63 87 409224 51020 79284057
Hospitalisation 79.13 9.63 235 409076 94001 79241076
Neuropathy peripheral 78.72 9.63 415 408896 140890 79194187
Hepatic cytolysis 75.65 9.63 308 409003 26843 79308234
Pyroglutamic acidosis 74.65 9.63 54 409257 1022 79334055
Alanine aminotransferase increased 73.90 9.63 1209 408102 161361 79173716
International normalised ratio increased 73.03 9.63 710 408601 84011 79251066
Injection site bruising 71.50 9.63 63 409248 40939 79294138
Neutrophil percentage increased 70.82 9.63 103 409208 4586 79330491
Renal impairment 70.31 9.63 497 408814 157286 79177791
Cardiac arrest 68.54 9.63 1253 408058 170843 79164234
Mucosal inflammation 68.24 9.63 182 409129 75398 79259679
Cognitive disorder 67.29 9.63 600 408711 69326 79265751
Hypersensitivity 66.24 9.63 1789 407522 260450 79074627
Pancytopenia 65.86 9.63 539 408772 165206 79169871
Blood pressure systolic abnormal 65.22 9.63 216 409095 17031 79318046
Body temperature decreased 65.17 9.63 332 408979 31813 79303264
Pyroglutamate increased 64.92 9.63 42 409269 657 79334420
Night sweats 61.97 9.63 469 408842 51626 79283451
Contraindicated product administered 61.68 9.63 1144 408167 156394 79178683
Lymphocyte percentage decreased 60.68 9.63 99 409212 4877 79330200
Anion gap abnormal 60.06 9.63 39 409272 614 79334463
White blood cells urine positive 59.86 9.63 110 409201 5965 79329112
Therapy interrupted 59.84 9.63 44 409267 31297 79303780
Therapy cessation 59.35 9.63 63 409248 37499 79297578
Crystal urine present 59.29 9.63 64 409247 2096 79332981
Urine abnormality 58.50 9.63 130 409181 8089 79326988
Suicide attempt 58.31 9.63 667 408644 82265 79252812
Blood pH decreased 57.82 9.63 94 409217 4617 79330460
Respiratory rate increased 57.79 9.63 242 409069 21358 79313719
Neoplasm progression 57.60 9.63 111 409200 51571 79283506
Rheumatic fever 57.40 9.63 294 409017 28231 79306846
Prostate cancer 56.95 9.63 52 409259 33216 79301861
Stomatitis 56.51 9.63 1063 408248 145694 79189383
Aspartate aminotransferase increased 56.45 9.63 1013 408298 137628 79197449
Pneumonia 55.62 9.63 2796 406515 657450 78677627
Urticaria 54.89 9.63 1291 408020 183910 79151167
Sedation 53.96 9.63 453 408858 51442 79283635
Drug abuse 53.84 9.63 1152 408159 161539 79173538
Coronary artery disease 53.02 9.63 166 409145 65308 79269769
Diabetes mellitus 52.66 9.63 215 409096 78175 79256902
Electric shock 52.43 9.63 49 409262 1345 79333732
Injection site warmth 52.31 9.63 7 409304 14800 79320277
Blood pressure diastolic increased 52.23 9.63 179 409132 14363 79320714
Cerebrovascular accident 52.12 9.63 527 408784 154765 79180312
Loss of personal independence in daily activities 51.84 9.63 311 409000 102269 79232808
Acute kidney injury 51.27 9.63 2162 407149 517242 78817835
Prothrombin time prolonged 50.54 9.63 196 409115 16703 79318374
Body temperature fluctuation 49.51 9.63 78 409233 3729 79331348
Full blood count abnormal 48.61 9.63 83 409228 40391 79294686
Septic shock 48.48 9.63 400 408911 122401 79212676
Bursitis 47.99 9.63 332 408979 35512 79299565
Flushing 47.63 9.63 676 408635 87592 79247485
Dyspnoea 47.60 9.63 3771 405540 853254 78481823
Posterior reversible encephalopathy syndrome 45.08 9.63 41 409270 26240 79308837
Dyspnoea exertional 44.52 9.63 263 409048 86810 79248267
Leukopenia 44.42 9.63 383 408928 116130 79218947
Confusional state 44.28 9.63 2026 407285 315971 79019106
Palmar-plantar erythrodysaesthesia syndrome 43.54 9.63 64 409247 33070 79302007
Decreased appetite 43.51 9.63 1382 407929 341036 78994041
Red blood cell sedimentation rate abnormal 43.28 9.63 27 409284 20936 79314141
Contusion 43.13 9.63 1034 408277 147742 79187335
Haematotoxicity 43.10 9.63 13 409298 15506 79319571
Injection site mass 43.07 9.63 25 409286 20159 79314918
Feeling abnormal 43.00 9.63 567 408744 158632 79176445
Unresponsive to stimuli 42.55 9.63 456 408855 55332 79279745
Swollen joint count increased 42.49 9.63 231 409080 22696 79312381
Fibromyalgia 42.36 9.63 511 408800 63829 79271248
Muscle spasticity 42.28 9.63 220 409091 21255 79313822
Cerebral haemorrhage 42.07 9.63 153 409158 57520 79277557
Device difficult to use 41.41 9.63 9 409302 13376 79321701
Cytomegalovirus infection 41.35 9.63 99 409212 42545 79292532
Product storage error 40.90 9.63 16 409295 16210 79318867
Oedema peripheral 40.86 9.63 984 408327 251304 79083773
Brain death 40.64 9.63 90 409221 5587 79329490
Orthostatic hypotension 40.51 9.63 454 408857 55710 79279367
No adverse event 40.47 9.63 81 409230 37111 79297966
Dizziness 40.38 9.63 2250 407061 524191 78810886
Urinary sediment present 40.22 9.63 57 409254 2478 79332599
Lymphocyte count decreased 40.10 9.63 395 408916 46894 79288183
Oesophageal carcinoma 39.74 9.63 5 409306 11079 79323998
Blood parathyroid hormone decreased 39.67 9.63 4 409307 10532 79324545
Haematochezia 39.55 9.63 275 409036 87370 79247707
Hyperkalaemia 39.31 9.63 386 408925 114012 79221065
Acidosis 39.29 9.63 203 409108 19559 79315518
Peripheral swelling 39.10 9.63 1725 407586 267892 79067185
Device issue 39.01 9.63 49 409262 27059 79308018
Hyperlipidaemia 38.78 9.63 46 409265 26047 79309030
Labelled drug-drug interaction medication error 38.74 9.63 51 409260 27599 79307478
Surgery 38.62 9.63 68 409243 32698 79302379
Epistaxis 38.01 9.63 377 408934 111138 79223939
Underdose 37.99 9.63 70 409241 33081 79301996
Product substitution issue 37.95 9.63 29 409282 20227 79314850
Injection site rash 37.24 9.63 23 409288 17931 79317146
Atrial fibrillation 36.84 9.63 755 408556 197131 79137946
Impaired quality of life 36.57 9.63 14 409297 14372 79320705
Brain oedema 36.22 9.63 238 409073 25025 79310052
Device malfunction 36.15 9.63 34 409277 21414 79313663
Dry skin 36.03 9.63 203 409108 67792 79267285
Immune reconstitution inflammatory syndrome 35.97 9.63 13 409298 13828 79321249
Drug screen positive 35.64 9.63 89 409222 5974 79329103
Arthralgia 35.31 9.63 3400 405911 568403 78766674
Bladder cancer 35.27 9.63 29 409282 19497 79315580
Lung neoplasm malignant 35.24 9.63 55 409256 27737 79307340
Anion gap increased 34.96 9.63 66 409245 3654 79331423
Diabetic ketoacidosis 34.88 9.63 77 409234 34045 79301032
Pathogen resistance 34.76 9.63 15 409296 14327 79320750
Haemolysis 34.63 9.63 144 409167 12668 79322409
Thrombocytopenia 34.54 9.63 1067 408244 264192 79070885
Injection site haemorrhage 34.54 9.63 56 409255 27814 79307263
Product quality issue 34.35 9.63 77 409234 33863 79301214
Urine leukocyte esterase positive 34.09 9.63 69 409242 4022 79331055
Extrapyramidal disorder 33.69 9.63 40 409271 22639 79312438
Red blood cells urine positive 33.65 9.63 77 409234 4886 79330191
Red cell distribution width increased 33.44 9.63 161 409150 15081 79319996
Dehydration 33.38 9.63 994 408317 247193 79087884
Specific gravity urine decreased 33.29 9.63 31 409280 847 79334230
Granuloma skin 33.23 9.63 4 409307 9170 79325907
Deep vein thrombosis postoperative 33.21 9.63 126 409185 10626 79324451
Post transplant lymphoproliferative disorder 32.95 9.63 9 409302 11455 79323622
Analgesic drug level above therapeutic 32.70 9.63 24 409287 465 79334612
Visual acuity reduced 32.22 9.63 64 409247 29405 79305672
Glycosylated haemoglobin increased 31.91 9.63 31 409280 19229 79315848
Acute myocardial infarction 31.75 9.63 248 409063 76788 79258289
Rash pruritic 31.71 9.63 226 409085 71403 79263674
Injection site induration 31.63 9.63 6 409305 9813 79325264
Bacterial test 31.42 9.63 35 409276 1188 79333889
Mobility decreased 31.24 9.63 835 408476 121340 79213737
Malaise 31.19 9.63 2130 407181 487739 78847338
Renal papillary necrosis 30.79 9.63 22 409289 408 79334669
Hypomagnesaemia 30.67 9.63 130 409181 46781 79288296
Facet joint syndrome 30.53 9.63 127 409184 11175 79323902
Device dislocation 30.51 9.63 54 409257 25916 79309161
Fall 30.42 9.63 2124 407187 485505 78849572
Liver transplant 30.41 9.63 69 409242 4354 79330723
Second primary malignancy 30.30 9.63 18 409293 14332 79320745
Cerebral infarction 30.22 9.63 126 409185 45550 79289527
Transient ischaemic attack 29.75 9.63 154 409157 52541 79282536
Illness 29.73 9.63 130 409181 46381 79288696
Systemic infection 29.29 9.63 7 409304 9745 79325332
Multiple-drug resistance 29.20 9.63 5 409306 8803 79326274
Sexual dysfunction 29.09 9.63 3 409308 7760 79327317
Soft tissue disorder 28.95 9.63 59 409252 3456 79331621
Unintentional medical device removal 28.85 9.63 3 409308 7709 79327368
Blood cholesterol increased 28.71 9.63 596 408715 83124 79251953
Dermatitis atopic 28.70 9.63 8 409303 10048 79325029
Hypocalcaemia 28.70 9.63 145 409166 49779 79285298
Pain 28.69 9.63 4075 405236 699727 78635350
Injury 28.68 9.63 558 408753 76938 79258139
Urine analysis abnormal 28.64 9.63 86 409225 6434 79328643
Nausea 28.44 9.63 4397 404914 952799 78382278
Anti-cyclic citrullinated peptide antibody 28.41 9.63 80 409231 5772 79329305
Precancerous cells present 28.40 9.63 33 409278 1174 79333903
Abdominal discomfort 28.38 9.63 1566 407745 249161 79085916
Myelodysplastic syndrome 28.09 9.63 72 409239 30229 79304848
Drug hypersensitivity 28.03 9.63 1251 408060 297665 79037412
Poor venous access 27.88 9.63 174 409137 17975 79317102
Angioedema 27.63 9.63 253 409058 75782 79259295
Hyponatraemia 27.60 9.63 698 408613 177150 79157927
Bilirubin urine present 27.27 9.63 19 409292 338 79334739
Cytopenia 27.14 9.63 39 409272 20344 79314733
Memory impairment 26.96 9.63 407 408904 111327 79223750
Therapeutic response shortened 26.86 9.63 156 409155 15707 79319370
Jaundice cholestatic 26.81 9.63 122 409189 11162 79323915
Frequent bowel movements 26.76 9.63 71 409240 29468 79305609
Hypertensive crisis 26.43 9.63 41 409270 20729 79314348
Cardiac failure chronic 26.43 9.63 12 409299 11123 79323954
Smear cervix abnormal 26.36 9.63 47 409264 2489 79332588
Lip dry 26.35 9.63 152 409159 15266 79319811
Electrocardiogram QT prolonged 26.23 9.63 317 408994 90069 79245008
Gait disturbance 26.20 9.63 838 408473 206668 79128409
Maternal exposure during pregnancy 26.00 9.63 900 408411 135638 79199439
Culture urine positive 25.97 9.63 65 409246 4370 79330707
Haematuria 25.91 9.63 227 409084 68609 79266468
Myalgia 25.83 9.63 740 408571 184901 79150176
Disturbance in attention 25.67 9.63 154 409157 50647 79284430
Inappropriate antidiuretic hormone secretion 25.58 9.63 61 409250 26252 79308825
Product monitoring error 25.58 9.63 7 409304 8899 79326178
Paraesthesia 25.52 9.63 699 408612 175624 79159453
Hypercalcaemia 25.43 9.63 106 409205 38324 79296753
Full blood count decreased 25.42 9.63 63 409248 26756 79308321
Iron deficiency anaemia 25.37 9.63 59 409252 25613 79309464
Infusion site pain 25.05 9.63 141 409170 14035 79321042
Forced expiratory volume decreased 24.70 9.63 5 409306 7809 79327268
General physical health deterioration 24.57 9.63 1158 408153 274080 79060997
Infusion site extravasation 24.55 9.63 110 409201 9998 79325079
Pneumocystis jirovecii pneumonia 24.53 9.63 85 409226 32423 79302654
Injection site urticaria 24.49 9.63 18 409293 12808 79322269
Transaminases increased 24.30 9.63 387 408924 51356 79283721
Syncope 24.29 9.63 718 408593 178731 79156346
Polyneuropathy 24.27 9.63 55 409256 24096 79310981
Panniculitis 24.10 9.63 17 409294 12354 79322723
Acute graft versus host disease 24.06 9.63 11 409300 10156 79324921
Respiratory disorder 23.98 9.63 343 408968 44513 79290564
Monocyte percentage increased 23.97 9.63 41 409270 2100 79332977
Obstructive airways disorder 23.92 9.63 82 409229 31377 79303700
Epilepsy 23.87 9.63 118 409193 40742 79294335
Renal failure 23.86 9.63 818 408493 200150 79134927
Rhinitis allergic 23.72 9.63 17 409294 12252 79322825
Basal cell carcinoma 23.57 9.63 105 409206 37270 79297807
Lactic acidosis 23.50 9.63 239 409072 70120 79264957
Unevaluable event 23.34 9.63 178 409133 55407 79279670
Hepatic encephalopathy 23.06 9.63 207 409104 23959 79311118
Endophthalmitis 22.80 9.63 3 409308 6425 79328652
Thrombotic microangiopathy 22.75 9.63 43 409268 20126 79314951
Disease recurrence 22.66 9.63 133 409178 43976 79291101
Eczema 22.65 9.63 120 409191 40698 79294379
Renal cortical necrosis 22.58 9.63 17 409294 343 79334734
Blood urine present 22.19 9.63 186 409125 21111 79313966
Drug intolerance 22.06 9.63 1607 407704 262512 79072565
Multiple drug therapy 22.05 9.63 58 409253 4020 79331057
Blood creatinine decreased 21.98 9.63 89 409222 7736 79327341
Ageusia 21.97 9.63 32 409279 16600 79318477
Graft versus host disease 21.79 9.63 27 409284 14999 79320078
Muscle spasms 21.49 9.63 708 408603 174022 79161055
Aspergillus infection 21.48 9.63 41 409270 19120 79315957
Cardiomyopathy 21.20 9.63 76 409235 28698 79306379
Asthenia 21.18 9.63 2301 407010 509388 78825689
Angina pectoris 21.10 9.63 167 409144 51565 79283512
Colorectal cancer 21.02 9.63 9 409302 8638 79326439
Coronary arterial stent insertion 21.02 9.63 3 409308 6041 79329036
Environmental exposure 20.91 9.63 17 409294 385 79334692
Cardiac failure acute 20.79 9.63 41 409270 18888 79316189
Gastrointestinal haemorrhage 20.76 9.63 588 408723 147131 79187946
Sepsis 20.70 9.63 1151 408160 268277 79066800
Infusion site pruritus 20.68 9.63 57 409254 4061 79331016
Aplastic anaemia 20.62 9.63 160 409151 17745 79317332
Maternal exposure timing unspecified 20.54 9.63 71 409240 5721 79329356
Asthma 20.48 9.63 532 408779 134563 79200514
Infusion site swelling 20.41 9.63 87 409224 7739 79327338
Febrile bone marrow aplasia 20.39 9.63 22 409289 12998 79322079
PCO2 decreased 20.36 9.63 48 409263 3106 79331971
Bacterial test positive 20.35 9.63 84 409227 7365 79327712
Hypothermia 20.27 9.63 192 409119 22554 79312523
Alopecia 20.23 9.63 1413 407898 229942 79105135
Haematocrit decreased 20.22 9.63 434 408877 60878 79274199
Rebound effect 20.16 9.63 6 409305 7220 79327857
Cholecystitis chronic 19.86 9.63 102 409209 9804 79325273
Device leakage 19.76 9.63 16 409295 10840 79324237
Hepatic cirrhosis 19.71 9.63 102 409209 34804 79300273
Chronic obstructive pulmonary disease 19.64 9.63 314 408997 85105 79249972
Neurotoxicity 19.52 9.63 93 409218 32425 79302652
Autoimmune disorder 19.44 9.63 149 409162 16463 79318614
Chills 19.35 9.63 1007 408304 159227 79175850
Peripheral venous disease 19.35 9.63 144 409167 15765 79319312
Acute myeloid leukaemia 19.33 9.63 87 409224 30798 79304279
Osteonecrosis 19.22 9.63 88 409223 31007 79304070
White blood cell count decreased 19.10 9.63 781 408530 187507 79147570
Haemorrhage 18.98 9.63 341 408970 90777 79244300
Myopathy 18.95 9.63 49 409262 20514 79314563
Skin exfoliation 18.88 9.63 186 409125 54914 79280163
Angina unstable 18.85 9.63 35 409276 16492 79318585
Nasal polyps 18.84 9.63 7 409304 7320 79327757
Hypertransaminasaemia 18.84 9.63 20 409291 11904 79323173
Platelet count decreased 18.78 9.63 812 408499 193852 79141225
Renal cancer 18.77 9.63 21 409290 12205 79322872
Ear pruritus 18.76 9.63 55 409256 4060 79331017
Thrombosis 18.72 9.63 311 409000 83789 79251288
Wound infection 18.71 9.63 197 409114 23794 79311283
Adrenergic syndrome 18.69 9.63 11 409300 144 79334933
Brain scan abnormal 18.67 9.63 27 409284 1196 79333881
Status epilepticus 18.55 9.63 66 409245 24975 79310102
Urine bilirubin decreased 18.49 9.63 11 409300 147 79334930
Skin ulcer 18.47 9.63 183 409128 53967 79281110
Pregnancy 18.44 9.63 215 409096 26636 79308441
Burning sensation 18.43 9.63 202 409109 58430 79276647
Spinal stenosis 18.40 9.63 33 409278 15758 79319319
Sleep disorder due to a general medical condition 18.35 9.63 28 409283 14249 79320828
Candida infection 18.19 9.63 118 409193 38096 79296981
Band neutrophil count increased 18.17 9.63 20 409291 670 79334407
Metastases to lymph nodes 18.09 9.63 16 409295 10381 79324696
Agranulocytosis 18.07 9.63 146 409165 44884 79290193
Prostatic specific antigen increased 18.06 9.63 16 409295 10370 79324707
Pulmonary mass 18.04 9.63 82 409229 28952 79306125
Infusion site erythema 18.00 9.63 96 409215 9364 79325713
Joint range of motion decreased 17.99 9.63 255 409056 33027 79302050
Therapy partial responder 17.99 9.63 39 409272 17358 79317719
Toxicologic test abnormal 17.88 9.63 28 409283 1332 79333745
Intervertebral discitis 17.84 9.63 60 409251 4768 79330309
Adjustment disorder with depressed mood 17.83 9.63 93 409218 8993 79326084
Cardiac disorder 17.82 9.63 234 409077 65523 79269554
Hypothyroidism 17.48 9.63 178 409133 52214 79282863
Insurance issue 17.45 9.63 4 409307 5729 79329348
Gastric cancer 17.31 9.63 16 409295 10163 79324914
Pain in extremity 17.30 9.63 1623 407688 362915 78972162
Cells in urine 17.29 9.63 12 409299 212 79334865
Mydriasis 17.28 9.63 152 409159 17491 79317586
Breast cancer female 17.25 9.63 20 409291 11441 79323636
Fracture 17.14 9.63 56 409255 21745 79313332
Infection 17.11 9.63 1452 407859 240260 79094817
Akathisia 17.04 9.63 26 409285 13233 79321844
Therapeutic response decreased 17.00 9.63 241 409070 66612 79268465
Eosinophil percentage increased 16.91 9.63 29 409282 1489 79333588
Mean cell haemoglobin concentration increased 16.90 9.63 22 409289 881 79334196
Transplant dysfunction 16.80 9.63 8 409303 7213 79327864
Dyslipidaemia 16.77 9.63 21 409290 11612 79323465
Skin toxicity 16.76 9.63 11 409300 8303 79326774
Skin necrosis 16.75 9.63 43 409268 18044 79317033
Gastrooesophageal reflux disease 16.74 9.63 407 408904 103839 79231238
Anaphylactic shock 16.70 9.63 112 409199 35884 79299193
Osmolar gap 16.68 9.63 11 409300 178 79334899
Dysphonia 16.68 9.63 199 409112 56673 79278404
Transplant rejection 16.65 9.63 48 409263 19389 79315688
Vision blurred 16.59 9.63 415 408896 105483 79229594
Drug abuser 16.58 9.63 68 409243 5945 79329132
Therapeutic response unexpected 16.55 9.63 50 409261 19896 79315181
Blood uric acid increased 16.41 9.63 27 409284 13333 79321744
Delirium 16.40 9.63 559 408752 84068 79251009
Ejection fraction decreased 16.34 9.63 107 409204 34470 79300607
Hepatic cancer 16.26 9.63 18 409293 10511 79324566
Pancreatic carcinoma 16.16 9.63 28 409283 13549 79321528
Product dose omission in error 16.12 9.63 10 409301 7778 79327299
Disturbance in social behaviour 16.09 9.63 3 409308 4967 79330110
Hypomania 16.05 9.63 79 409232 7465 79327612
Dysgeusia 16.03 9.63 202 409109 56975 79278102
Subdural haematoma 16.03 9.63 95 409216 31339 79303738
Ascites 15.99 9.63 282 409029 75280 79259797
Tachycardia 15.94 9.63 1088 408223 176680 79158397
Haemoglobin urine present 15.93 9.63 22 409289 933 79334144
Pruritus 15.90 9.63 2284 407027 392364 78942713
Metastases to liver 15.84 9.63 83 409228 28231 79306846
Toxic epidermal necrolysis 15.82 9.63 319 408992 44262 79290815
Serum sickness 15.77 9.63 48 409263 3618 79331459
Anti-erythrocyte antibody positive 15.71 9.63 8 409303 77 79335000
Gynaecomastia 15.71 9.63 10 409301 7671 79327406
Granulomatosis with polyangiitis 15.70 9.63 41 409270 2829 79332248
Cytomegalovirus infection reactivation 15.67 9.63 13 409298 8703 79326374
Cytomegalovirus viraemia 15.67 9.63 26 409285 12795 79322282
Enthesopathy 15.67 9.63 22 409289 11586 79323491
Accidental death 15.57 9.63 53 409258 4238 79330839
Ventricular tachycardia 15.47 9.63 139 409172 41796 79293281
Carpal tunnel syndrome 15.46 9.63 50 409261 19478 79315599
Diffuse large B-cell lymphoma 15.44 9.63 24 409287 12125 79322952
Hepatitis B reactivation 15.43 9.63 6 409305 6102 79328975
Nocardiosis 15.34 9.63 5 409306 5674 79329403
Condition aggravated 15.25 9.63 2298 407013 498826 78836251
Coronary artery bypass 15.24 9.63 6 409305 6056 79329021
Drug level below therapeutic 15.21 9.63 94 409217 9676 79325401
Hip arthroplasty 15.16 9.63 263 409048 35493 79299584
Actinic keratosis 15.16 9.63 6 409305 6036 79329041
Diplopia 15.10 9.63 105 409206 33361 79301716
Chronic graft versus host disease 15.04 9.63 8 409303 6773 79328304
Rheumatoid nodule 14.99 9.63 43 409268 17395 79317682
Musculoskeletal stiffness 14.97 9.63 1067 408244 173941 79161136
Specific gravity urine increased 14.93 9.63 15 409296 451 79334626
Blindness 14.89 9.63 85 409226 28298 79306779
Sputum culture positive 14.88 9.63 48 409263 3733 79331344
Dependent personality disorder 14.77 9.63 9 409302 126 79334951
Metastases to lung 14.74 9.63 46 409265 18117 79316960
Methaemoglobinaemia 14.66 9.63 62 409249 5495 79329582
Infusion site mass 14.64 9.63 28 409283 1565 79333512
Abortion spontaneous 14.62 9.63 90 409221 29417 79305660
Lupus vulgaris 14.57 9.63 44 409267 3302 79331775
Blood bicarbonate decreased 14.55 9.63 59 409252 5132 79329945
Urinary casts 14.52 9.63 24 409287 1195 79333882
Sinus node dysfunction 14.46 9.63 11 409300 7690 79327387
Temperature regulation disorder 14.45 9.63 64 409247 5789 79329288
Mean cell haemoglobin concentration decreased 14.42 9.63 54 409257 4525 79330552
Tendonitis 14.40 9.63 68 409243 23762 79311315
Electrolyte imbalance 14.37 9.63 96 409215 30785 79304292
Epstein-Barr virus infection 14.35 9.63 33 409278 14383 79320694
Withdrawal syndrome 14.32 9.63 80 409231 26774 79308303
Rash maculo-papular 14.31 9.63 202 409109 55876 79279201
Fluid retention 14.30 9.63 262 409049 69547 79265530
Congestive cardiomyopathy 14.29 9.63 24 409287 11756 79323321
C-reactive protein 14.28 9.63 57 409254 4922 79330155
Dyspnoea at rest 14.27 9.63 10 409301 7292 79327785
Venoocclusive liver disease 14.26 9.63 24 409287 11747 79323330
Partial seizures 14.25 9.63 15 409296 8963 79326114
Right ventricular failure 14.22 9.63 67 409244 23430 79311647
Erysipelas 14.21 9.63 21 409290 10829 79324248
Pulmonary toxicity 14.16 9.63 28 409283 12886 79322191
Deep vein thrombosis 14.15 9.63 493 408818 120426 79214651
Shock haemorrhagic 14.12 9.63 54 409257 20006 79315071
Post-traumatic stress disorder 14.10 9.63 56 409255 4825 79330252
Swollen tongue 14.05 9.63 145 409166 42425 79292652
Thinking abnormal 14.03 9.63 29 409282 13132 79321945
Pharyngeal paraesthesia 14.00 9.63 38 409273 2683 79332394
Decerebrate posture 13.97 9.63 10 409301 186 79334891
Blood triglycerides increased 13.94 9.63 58 409253 20982 79314095
Mental status changes 13.92 9.63 446 408865 66513 79268564
Visual impairment 13.91 9.63 363 408948 91768 79243309
Aphasia 13.90 9.63 163 409148 46569 79288508
Nocturia 13.88 9.63 31 409280 13650 79321427
Nasal necrosis 13.84 9.63 9 409302 142 79334935
Bronchopulmonary aspergillosis 13.83 9.63 63 409248 22231 79312846
Pulmonary arterial hypertension 13.80 9.63 87 409224 28279 79306798
Urine ketone body present 13.79 9.63 45 409266 3520 79331557
Alpha 1 microglobulin increased 13.78 9.63 7 409304 67 79335010
Encephalopathy 13.78 9.63 448 408863 66949 79268128
Altered state of consciousness 13.76 9.63 151 409160 43671 79291406
Loss of consciousness 13.72 9.63 713 408598 167230 79167847
Seizure 13.72 9.63 811 408500 188023 79147054
Suicidal ideation 13.68 9.63 293 409018 76047 79259030
Renal disorder 13.66 9.63 144 409167 41961 79293116
Hypertriglyceridaemia 13.64 9.63 28 409283 12712 79322365
Chronic kidney disease 13.64 9.63 248 409063 65906 79269171
Activated partial thromboplastin time prolonged 13.64 9.63 122 409189 14106 79320971
Pulmonary embolism 13.60 9.63 731 408580 170923 79164154
Drug eruption 13.56 9.63 152 409159 43783 79291294
Balance disorder 13.54 9.63 629 408682 98228 79236849
Skin burning sensation 13.52 9.63 30 409281 13242 79321835
Leukocytosis 13.50 9.63 305 409006 43150 79291927
Blood bilirubin increased 13.47 9.63 440 408871 65792 79269285
Lymphoproliferative disorder 13.41 9.63 6 409305 5609 79329468
Urobilinogen urine increased 13.35 9.63 17 409294 666 79334411
Pain in jaw 13.34 9.63 162 409149 45989 79289088
Hepatocellular carcinoma 13.30 9.63 16 409295 9005 79326072
Pyrexia 13.29 9.63 3791 405520 674918 78660159
Abnormal loss of weight 13.29 9.63 14 409297 8362 79326715
Respiratory tract congestion 13.23 9.63 55 409256 19899 79315178
Injection site extravasation 13.20 9.63 90 409221 9579 79325498
Impaired work ability 13.20 9.63 54 409257 19627 79315450
Lipodystrophy acquired 13.20 9.63 3 409308 4322 79330755
Blood glucose increased 13.17 9.63 470 408841 114505 79220572
Abnormal dreams 13.16 9.63 24 409287 11388 79323689
Stevens-Johnson syndrome 13.16 9.63 278 409033 38888 79296189
Fungal rhinitis 13.10 9.63 7 409304 75 79335002
Dislocation of vertebra 13.02 9.63 77 409234 7803 79327274
Derailment 12.94 9.63 7 409304 77 79335000
Metastases to bone 12.90 9.63 73 409238 24354 79310723
Eye pruritus 12.84 9.63 58 409253 20512 79314565
Macular oedema 12.83 9.63 6 409305 5468 79329609
Spinal operation 12.82 9.63 13 409298 7904 79327173
Anosmia 12.71 9.63 16 409295 8828 79326249
Accidental poisoning 12.70 9.63 27 409284 1630 79333447
Diffuse large B-cell lymphoma recurrent 12.67 9.63 3 409308 4204 79330873
Paradoxical drug reaction 12.57 9.63 11 409300 7174 79327903
Base excess 12.56 9.63 7 409304 82 79334995
Speech disorder 12.56 9.63 200 409111 54245 79280832
Hallucination, auditory 12.53 9.63 59 409252 20634 79314443
Diaphragmatic rupture 12.51 9.63 10 409301 221 79334856
Vitamin K deficiency 12.49 9.63 17 409294 711 79334366
Abdominal pain upper 12.48 9.63 1322 407989 222497 79112580
Traumatic liver injury 12.46 9.63 16 409295 632 79334445
Subarachnoid haemorrhage 12.44 9.63 74 409237 24391 79310686
Tremor 12.44 9.63 730 408581 169353 79165724
Skin lesion 12.43 9.63 146 409165 41698 79293379
Carotid artery stenosis 12.43 9.63 16 409295 8742 79326335
Eosinophilia 12.42 9.63 161 409150 45184 79289893
Pulmonary hypertension 12.34 9.63 173 409138 47907 79287170
Blood uric acid decreased 12.29 9.63 23 409288 1265 79333812
Angiokeratoma 12.28 9.63 10 409301 227 79334850
Metastases to central nervous system 12.23 9.63 43 409268 16332 79318745
Procedural pain 12.18 9.63 69 409242 23015 79312062
Sensitivity to weather change 12.16 9.63 14 409297 8033 79327044
Hallucination 12.12 9.63 341 408970 85404 79249673
Blood lactic acid increased 12.07 9.63 109 409202 12635 79322442
Eyelid ptosis 12.06 9.63 24 409287 11020 79324057
Ischaemic cardiomyopathy 12.05 9.63 13 409298 7682 79327395
Graft versus host disease in gastrointestinal tract 12.03 9.63 9 409302 6347 79328730
Oxygen saturation abnormal 12.00 9.63 51 409260 4531 79330546
Sleep terror 11.91 9.63 4 409307 4454 79330623
Gallbladder injury 11.89 9.63 22 409289 1199 79333878
Carotid artery occlusion 11.89 9.63 13 409298 7634 79327443
Psychomotor skills impaired 11.88 9.63 6 409305 5231 79329846
Rash 11.87 9.63 3237 406074 575121 78759956
Urine oxalate increased 11.85 9.63 10 409301 239 79334838
Sudden cardiac death 11.84 9.63 6 409305 5219 79329858
Autonomic dysreflexia 11.82 9.63 13 409298 435 79334642
Pneumonia viral 11.77 9.63 84 409227 9074 79326003
Injection site discolouration 11.77 9.63 13 409298 7601 79327476
pH urine increased 11.72 9.63 13 409298 439 79334638
Myelocyte percentage increased 11.68 9.63 10 409301 244 79334833
Genital haemorrhage 11.66 9.63 9 409302 6246 79328831
Ammonia increased 11.60 9.63 73 409238 7562 79327515
Dermatitis exfoliative generalised 11.60 9.63 12 409299 7229 79327848
Pulmonary alveolar haemorrhage 11.59 9.63 26 409285 11431 79323646
BK virus infection 11.57 9.63 17 409294 8787 79326290
Skin cancer 11.57 9.63 39 409272 15001 79320076
Hemiparesis 11.51 9.63 114 409197 33619 79301458
Hypoglycaemic coma 11.50 9.63 5 409306 4755 79330322
Endocardial fibrosis 11.50 9.63 6 409305 61 79335016
Acid-base balance disorder mixed 11.49 9.63 7 409304 98 79334979
Bone pain 11.48 9.63 209 409102 55533 79279544
Skin haemorrhage 11.47 9.63 28 409283 11953 79323124
Transferrin decreased 11.47 9.63 12 409299 379 79334698
Congestive hepatopathy 11.44 9.63 50 409261 4497 79330580
Stent placement 11.39 9.63 10 409301 6510 79328567
Immunosuppressant drug level increased 11.32 9.63 18 409293 9009 79326068
Ankylosing spondylitis 11.31 9.63 29 409282 12176 79322901
Extra dose administered 11.30 9.63 16 409295 8399 79326678
Rash papular 11.30 9.63 66 409245 21850 79313227
Fear of injection 11.30 9.63 13 409298 7461 79327616
Vertigo 11.29 9.63 269 409042 68813 79266264
Ischaemic stroke 11.29 9.63 112 409199 33019 79302058
Brain stem glioma 11.25 9.63 9 409302 199 79334878
JC virus infection 11.24 9.63 3 409308 3878 79331199
Nail bed inflammation 11.24 9.63 14 409297 536 79334541
Glucose tolerance impaired 11.23 9.63 15 409296 8069 79327008
Neuroleptic malignant syndrome 11.22 9.63 89 409222 27470 79307607
Depression 11.18 9.63 959 408352 215831 79119246
Blood creatine increased 11.17 9.63 85 409226 9370 79325707
Retinal deposits 11.17 9.63 8 409303 149 79334928
Drug tolerance 11.16 9.63 17 409294 8658 79326419
Haemophagocytic lymphohistiocytosis 11.13 9.63 66 409245 21771 79313306
Treatment noncompliance 11.08 9.63 195 409116 52073 79283004
Neutrophil count decreased 11.01 9.63 383 408928 93576 79241501
Rheumatoid lung 11.01 9.63 4 409307 4241 79330836
Human herpesvirus 6 infection 10.97 9.63 7 409304 5363 79329714
Lip swelling 10.93 9.63 146 409165 40765 79294312
Hypokalaemia 10.93 9.63 616 408695 143424 79191653
Coagulation factor X level decreased 10.90 9.63 7 409304 108 79334969
Taste disorder 10.87 9.63 43 409268 15780 79319297
Acute graft versus host disease in skin 10.86 9.63 14 409297 7644 79327433
Cystitis haemorrhagic 10.84 9.63 19 409292 9153 79325924
Mitral valve incompetence 10.84 9.63 94 409217 28471 79306606
Injection site nodule 10.80 9.63 3 409308 3777 79331300
Cerebral artery thrombosis 10.80 9.63 20 409291 1091 79333986
Colitis 10.76 9.63 290 409021 73017 79262060
Bone erosion 10.74 9.63 51 409260 17796 79317281
Leukoencephalopathy 10.73 9.63 15 409296 7914 79327163
Left ventricular dysfunction 10.69 9.63 57 409254 19304 79315773
Tardive dyskinesia 10.68 9.63 24 409287 10547 79324530
Aortic valve stenosis 10.68 9.63 7 409304 5287 79329790
Needle issue 10.67 9.63 33 409278 13035 79322042
Dermatitis acneiform 10.67 9.63 22 409289 9971 79325106
Dysstasia 10.66 9.63 91 409220 27655 79307422
Post procedural pulmonary embolism 10.63 9.63 10 409301 277 79334800
Anti-neutrophil cytoplasmic antibody positive vasculitis 10.58 9.63 3 409308 3726 79331351
Dermatitis 10.58 9.63 65 409246 21256 79313821
Gestational diabetes 10.58 9.63 10 409301 6283 79328794
Band neutrophil percentage increased 10.55 9.63 12 409299 417 79334660
Vitamin B12 deficiency 10.51 9.63 13 409298 7228 79327849
Anoxia 10.45 9.63 11 409300 350 79334727
Osteolysis 10.44 9.63 5 409306 4493 79330584
Vessel puncture site bruise 10.41 9.63 13 409298 499 79334578
Atrioventricular block 10.40 9.63 37 409274 14004 79321073
Rhabdomyolysis 10.40 9.63 428 408883 102703 79232374
Limb discomfort 10.39 9.63 113 409198 32737 79302340
Pruritus genital 10.39 9.63 5 409306 4481 79330596
Tricuspid valve incompetence 10.36 9.63 59 409252 19653 79315424
Nose deformity 10.35 9.63 8 409303 168 79334909
Aplasia pure red cell 10.34 9.63 15 409296 7795 79327282
Soft tissue injury 10.32 9.63 26 409285 1755 79333322
Mycobacterial infection 10.32 9.63 3 409308 3665 79331412
Adenocarcinoma of colon 10.29 9.63 8 409303 5533 79329544
Palpitations 10.25 9.63 538 408773 126072 79209005
Drug-induced liver injury 10.23 9.63 426 408885 65691 79269386
Pancreatic pseudoaneurysm 10.23 9.63 6 409305 78 79334999
Bradycardia neonatal 10.23 9.63 6 409305 78 79334999
Continuous haemodiafiltration 10.22 9.63 28 409283 1988 79333089
Flatulence 10.17 9.63 156 409155 42568 79292509
Organising pneumonia 10.13 9.63 26 409285 10913 79324164
Accident at home 10.12 9.63 8 409303 174 79334903
Cerebral ischaemia 10.07 9.63 27 409284 11168 79323909
Low density lipoprotein increased 10.06 9.63 18 409293 8604 79326473
Dysarthria 10.05 9.63 267 409044 67355 79267722
Toxic skin eruption 10.03 9.63 70 409241 22223 79312854
Excessive skin 10.02 9.63 7 409304 125 79334952
Cardiovascular disorder 9.99 9.63 53 409258 17972 79317105
Oral discomfort 9.99 9.63 22 409289 9738 79325339
Laryngospasm 9.98 9.63 4 409307 3993 79331084
Prescribed underdose 9.96 9.63 100 409211 29414 79305663
Sinus tachycardia 9.93 9.63 254 409057 36654 79298423
Brain herniation 9.91 9.63 69 409242 7394 79327683
Intestinal haemorrhage 9.91 9.63 11 409300 6415 79328662
Dysuria 9.89 9.63 193 409118 50758 79284319
Alcohol use 9.86 9.63 50 409261 4781 79330296
Magnesium deficiency 9.85 9.63 14 409297 610 79334467
Graft versus host disease in skin 9.80 9.63 10 409301 6063 79329014
Respiratory alkalosis 9.79 9.63 46 409265 4265 79330812
Ductus arteriosus stenosis foetal 9.79 9.63 6 409305 85 79334992
Cytokine release syndrome 9.77 9.63 248 409063 35750 79299327
Kidney transplant rejection 9.76 9.63 24 409287 10222 79324855
Large intestine polyp 9.74 9.63 33 409278 12675 79322402
Retinal haemorrhage 9.73 9.63 17 409294 8200 79326877
Bronchiectasis 9.73 9.63 71 409240 22315 79312762
Multiple organ dysfunction syndrome 9.72 9.63 511 408800 119735 79215342
Self-medication 9.71 9.63 52 409259 5080 79329997
Acute respiratory failure 9.68 9.63 232 409079 59309 79275768
Acute coronary syndrome 9.68 9.63 66 409245 21067 79314010
Rectal cancer 9.65 9.63 3 409308 3510 79331567
Monoparesis 9.64 9.63 3 409308 3508 79331569
Osteomyelitis 9.63 9.63 115 409196 32750 79302327

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC D11AX26 DERMATOLOGICALS
OTHER DERMATOLOGICAL PREPARATIONS
OTHER DERMATOLOGICAL PREPARATIONS
Other dermatologicals
ATC N06BC01 NERVOUS SYSTEM
PSYCHOANALEPTICS
PSYCHOSTIMULANTS, AGENTS USED FOR ADHD AND NOOTROPICS
Xanthine derivatives
ATC V04CG30 VARIOUS
DIAGNOSTIC AGENTS
OTHER DIAGNOSTIC AGENTS
Tests for gastric secretion
FDA CS M0023046 Xanthines
MeSH PA D002491 Central Nervous System Agents
MeSH PA D000697 Central Nervous System Stimulants
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D010726 Phosphodiesterase Inhibitors
MeSH PA D058914 Purinergic Antagonists
MeSH PA D058915 Purinergic P1 Receptor Antagonists
FDA PE N0000175729 Central Nervous System Stimulation
FDA EPC N0000175739 Central Nervous System Stimulant
FDA EPC N0000175790 Methylxanthine
CHEBI has role CHEBI:25435 mutagens
CHEBI has role CHEBI:35337 analeptic
CHEBI has role CHEBI:35471 psychotropic drugs
CHEBI has role CHEBI:35498 diuretics
CHEBI has role CHEBI:35703 Xenobiotic
CHEBI has role CHEBI:50218 phosphodiesterase inhibitors
CHEBI has role CHEBI:50925 serine/threonine protein kinase inhibitor
CHEBI has role CHEBI:53121 adenosine A2A receptor antagonists
CHEBI has role CHEBI:60809 adjuvants
CHEBI has role CHEBI:64047 food additives
CHEBI has role CHEBI:67114 ryanodine receptor activators
CHEBI has role CHEBI:71232 adenosine receptor antagonists
CHEBI has role CHEBI:75771 Mus musculus metabolites
CHEBI has role CHEBI:76924 plant metabolites
CHEBI has role CHEBI:76946 fungal metabolites
CHEBI has role CHEBI:78298 environmental contaminants
CHEBI has role CHEBI:85234 human blood serum metabolites
CHEBI has role CHEBI:176497 geroprotectors

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Sinus headache indication 4969004
Apnea in the newborn indication 13094009
Pain indication 22253000
Migraine indication 37796009 DOID:6364
Joint pain indication 57676002
Allergic rhinitis indication 61582004
Nasal discharge indication 64531003
Nasal congestion indication 68235000
Common cold indication 82272006 DOID:10459
Vascular headache indication 128187005
Backache indication 161891005
Cluster headache syndrome indication 193031009
Spasticity indication 221360009
Headache disorder indication 230461009
Dysmenorrhea indication 266599000
Influenza-like symptoms indication 315642008
Tension-type headache indication 398057008
Cluster Headache Prevention indication
Fatigue off-label use 84229001
Urinary incontinence off-label use 165232002
Obesity off-label use 414916001 DOID:9970
Brain damage contraindication 2470005
Necrotizing enterocolitis in fetus OR newborn contraindication 2707005
Ocular hypertension contraindication 4210003 DOID:9282
Gastritis contraindication 4556007 DOID:4029
Hypophosphatemia contraindication 4996001
Tachyarrhythmia contraindication 6285003
Suicidal thoughts contraindication 6471006
Dependent drug abuse contraindication 6525002
Urinary tract obstruction contraindication 7163005 DOID:5200
Alcoholism contraindication 7200002
Alcohol withdrawal delirium contraindication 8635005
Hyperammonemia contraindication 9360008
Peptic ulcer contraindication 13200003 DOID:750
Chronic obstructive lung disease contraindication 13645005 DOID:3083
Asthenia contraindication 13791008
Hepatic encephalopathy contraindication 13920009 DOID:13413
Hyperkalemia contraindication 14140009
Severe chronic ulcerative colitis contraindication 14311001
Constipation contraindication 14760008 DOID:2089
Chronic disease of respiratory system contraindication 17097001
Mood swings contraindication 18963009
Myocardial infarction contraindication 22298006 DOID:5844
Glaucoma contraindication 23986001 DOID:1686
Inflammatory bowel disease contraindication 24526004 DOID:0050589
Ventricular tachycardia contraindication 25569003
Alcohol intoxication contraindication 25702006
Complete atrioventricular block contraindication 27885002
Shock contraindication 27942005
Toxic megacolon contraindication 28536002 DOID:1770
Hypovolemia contraindication 28560003
Orthostatic hypotension contraindication 28651003
Acute cerebrovascular insufficiency contraindication 29322000
Atony of colon contraindication 29479008
Hypercapnia contraindication 29596007
Dehydration contraindication 34095006
Hyperthyroidism contraindication 34486009 DOID:7998
Depressive disorder contraindication 35489007
Acute hepatitis contraindication 37871000
Hypertensive disorder contraindication 38341003 DOID:10763
Disorder of gallbladder contraindication 39621005 DOID:0060262
Gastrointestinal ulcer contraindication 40845000
Hypothyroidism contraindication 40930008 DOID:1459
Complete trisomy 21 syndrome contraindication 41040004 DOID:14250
Hypokalemia contraindication 43339004
Body fluid retention contraindication 43498006
Hyperactive behavior contraindication 44548000
Fecal impaction contraindication 44635007
Conduction disorder of the heart contraindication 44808001
Low blood pressure contraindication 45007003
Achalasia of esophagus contraindication 45564002 DOID:9164
Chronic heart failure contraindication 48447003
Bradycardia contraindication 48867003
Retroperitoneal fibrosis contraindication 49120005
Disorder of cardiovascular system contraindication 49601007 DOID:1287
Acidosis contraindication 51387008
Fibrosis of lung contraindication 51615001 DOID:3770
Gastrointestinal perforation contraindication 51875005
Vitamin K deficiency contraindication 52675005 DOID:11249
Nasal polyp contraindication 52756005
Gastrectomy contraindication 53442002
Paralytic ileus contraindication 55525008 DOID:8442
Peptic reflux disease contraindication 57643001
Congenital myotonia, autosomal dominant form contraindication 57938005
Acute nephropathy contraindication 58574008
Leber's optic atrophy contraindication 58610003 DOID:705
Hepatic failure contraindication 59927004
Diarrhea contraindication 62315008
Thrombophlebitis contraindication 64156001 DOID:3875
Ulcerative colitis contraindication 64766004 DOID:8577
Blood coagulation disorder contraindication 64779008 DOID:1247
Arterial thrombosis contraindication 65198009
Drug AND/OR toxin-induced diarrhea contraindication 65979008
Substance abuse contraindication 66214007
Hypermagnesemia contraindication 66978005
Benign intracranial hypertension contraindication 68267002 DOID:11459
Hemorrhoids contraindication 70153002 DOID:9746
Poisoning by acetaminophen contraindication 70273001
Agoraphobia contraindication 70691001 DOID:593
Arteriosclerotic vascular disease contraindication 72092001
Hepatic coma contraindication 72836002 DOID:12550
Diabetes mellitus contraindication 73211009 DOID:9351
Sleep apnea contraindication 73430006 DOID:0050847
Factor II deficiency contraindication 73975000
Reye's syndrome contraindication 74351001 DOID:14525
Gastrointestinal hemorrhage contraindication 74474003
Urethral stricture contraindication 76618002
Thrombotic thrombocytopenic purpura contraindication 78129009 DOID:10772
Spastic paralysis contraindication 78403003
Disturbance of salivary secretion contraindication 78948009
Decreased respiratory function contraindication 80954004
Injury of head contraindication 82271004
Chronic idiopathic constipation contraindication 82934008
Cor pulmonale contraindication 83291003 DOID:8515
Hiatal hernia contraindication 84089009 DOID:12642
Atrophic gastritis contraindication 84568007 DOID:8929
Epilepsy contraindication 84757009 DOID:1826
Pulmonary emphysema contraindication 87433001
Gout contraindication 90560007 DOID:13189
Chronic renal failure syndrome contraindication 90688005
Kidney disease contraindication 90708001 DOID:557
Thyrotoxicosis contraindication 90739004 DOID:7997
Hemophilia contraindication 90935002
Myasthenia gravis contraindication 91637004 DOID:437
Obstruction of duodenum contraindication 95532008 DOID:3558
Disorder of biliary tract contraindication 105997008 DOID:9741
Anemia due to enzyme deficiency contraindication 111577008
Prolonged QT interval contraindication 111975006
Acute abdominal pain contraindication 116290004
Procedure on urinary system contraindication 118677009
Gastrointestinal obstruction contraindication 126765001
Neoplasm of brain contraindication 126952004 DOID:1319
von Willebrand disorder contraindication 128105004 DOID:12531
Seizure disorder contraindication 128613002
Autonomic dysreflexia contraindication 129618003
Bleeding contraindication 131148009
Prolonged PR interval contraindication 164947007
Drug-induced psychosis contraindication 191483003 DOID:1742
Obsessive-compulsive disorder contraindication 191736004 DOID:10933
Insomnia contraindication 193462001
Partial atrioventricular block contraindication 195039008
Decompensated cardiac failure contraindication 195111005
Acute pancreatitis contraindication 197456007 DOID:2913
Impaired renal function disorder contraindication 197663003
Coronary artery bypass graft contraindication 232717009
Myocardial dysfunction contraindication 233928007
Peripheral ischemia contraindication 233958001
Gastroesophageal reflux disease contraindication 235595009 DOID:8534
Gastroparesis contraindication 235675006
Disease of liver contraindication 235856003 DOID:409
Chronic diarrhea contraindication 236071009
Hyporeninemic hypoaldosteronism contraindication 236464008
Aluminum intoxication contraindication 236546003
Bladder outflow obstruction contraindication 236645006
Morbid obesity contraindication 238136002 DOID:11981
Sepsis syndrome contraindication 238150007
Pyloric obstruction contraindication 244815007
Sleep automatism contraindication 247962006
Raynaud's phenomenon contraindication 266261006
Benign prostatic hyperplasia contraindication 266569009
Retention of urine contraindication 267064002
Anemia contraindication 271737000 DOID:2355
Drowsy contraindication 271782001
Exacerbation of asthma contraindication 281239006
Cerebral ischemia contraindication 287731003
Pregnancy, function contraindication 289908002
Lesion of brain contraindication 301766008
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Neutropenic disorder contraindication 303011007 DOID:1227
Familial hyperkalemic periodic paralysis contraindication 304737009 DOID:14451
Panic disorder contraindication 371631005 DOID:594
Coma contraindication 371632003
Primary adrenocortical insufficiency contraindication 373662000
Operation on gastrointestinal tract contraindication 386621005
Hypoxia contraindication 389086002
Angle-closure glaucoma contraindication 392291006 DOID:13550
Cardiovascular event risk contraindication 395112001
Pseudomembranous enterocolitis contraindication 397683000
Gastric ulcer contraindication 397825006 DOID:10808
Peripheral vascular disease contraindication 400047006
Respiratory insufficiency contraindication 409623005
Breastfeeding (mother) contraindication 413712001
Chronic lung disease contraindication 413839001
Chronic myocardial ischemia contraindication 413844008 DOID:3393
Disorder of coronary artery contraindication 414024009
Myocardial ischemia contraindication 414795007 DOID:3393
Myocardial infarction in recovery phase contraindication 418044006
Central nervous system depression contraindication 418072004
Porphyria contraindication 418470004
Ultrarapid metabolizer due to cytochrome p450 CYP2D6 variant contraindication 422681000
Dysfunction of sphincter of Oddi contraindication 430887001
Fibrosis of pleura contraindication 442110002
Congenital long QT syndrome contraindication 442917000
Hypertensive urgency contraindication 443482000
Acute erosive gastritis contraindication 444926003
Smokes tobacco daily contraindication 449868002
Severe dehydration contraindication 450316000
Acute exacerbation of asthma contraindication 708038006
Ergot Alkaloid Toxicity contraindication
Acute Thromboembolic Stroke contraindication
Organic Cardiac Disease contraindication
Severe Pruritus contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 1.86 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Adenosine receptor A1 GPCR ANTAGONIST Ki 4.97 IUPHAR CHEMBL
Adenosine receptor A2b GPCR ANTAGONIST Ki 4.77 WOMBAT-PK CHEMBL
Adenosine receptor A2a GPCR ANTAGONIST Ki 5.61 CHEMBL CHEMBL
Acetylcholinesterase Enzyme IC50 5.14 CHEMBL
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform Kinase IC50 4.12 CHEMBL
Guanine deaminase Enzyme Ki 4.99 CHEMBL
Potassium voltage-gated channel subfamily H member 2 Ion channel IC50 5.31 CHEMBL
Adenosine receptor A3 GPCR ANTAGONIST Ki 4.33 WOMBAT-PK
Glycogen phosphorylase, muscle form Enzyme IC50 4.13 CHEMBL
Adenosine receptor A1 GPCR Ki 4.77 CHEMBL
Adenosine receptor A2a GPCR Ki 5.03 CHEMBL
Adenosine receptor A1 GPCR Ki 4.54 CHEMBL
Adenosine receptor A1 GPCR Ki 4 CHEMBL
Adenosine A2 receptor GPCR Ki 4.57 CHEMBL
Adenosine receptor GPCR Ki 4.22 CHEMBL
Adenosine A2a receptor GPCR Ki 4.10 CHEMBL
Adenosine receptor A2b GPCR ANTAGONIST Ki 4.89 IUPHAR

External reference:

IDSource
4017537 VUID
N0000145919 NUI
D00528 KEGG_DRUG
69-22-7 SECONDARY_CAS_RN
1886 RXNORM
C0006644 UMLSCUI
CHEBI:27732 CHEBI
CFF PDB_CHEM_ID
CHEMBL113 ChEMBL_ID
DB00201 DRUGBANK_ID
CHEMBL1200569 ChEMBL_ID
D002110 MESH_DESCRIPTOR_UI
2519 PUBCHEM_CID
C026189 MESH_SUPPLEMENTAL_RECORD_UI
407 IUPHAR_LIGAND_ID
3G6A5W338E UNII
11623 MMSL
17093 MMSL
4318 MMSL
4319 MMSL
46084 MMSL
4939 MMSL
d00801 MMSL
1269198007 SNOMEDCT_US
23068001 SNOMEDCT_US
255641001 SNOMEDCT_US
91107009 SNOMEDCT_US
4017537 VANDF
4018995 VANDF
000600 NDDF
000601 NDDF

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Fiorinal with Codeine HUMAN PRESCRIPTION DRUG LABEL 4 0023-6010 CAPSULE 40 mg ORAL NDA 36 sections
Fiorinal HUMAN PRESCRIPTION DRUG LABEL 3 0023-6146 CAPSULE 40 mg ORAL NDA 23 sections
Butalbital, Acetaminophen, Caffeine and Codeine Phosphate HUMAN PRESCRIPTION DRUG LABEL 4 0054-0650 CAPSULE 40 mg ORAL ANDA 33 sections
Butalbital, Acetaminophen, Caffeine and Codeine Phosphate HUMAN PRESCRIPTION DRUG LABEL 4 0054-0650 CAPSULE 40 mg ORAL ANDA 33 sections
Butalbital, Acetaminophen, Caffeine and Codeine Phosphate HUMAN PRESCRIPTION DRUG LABEL 4 0054-3000 CAPSULE 40 mg ORAL ANDA 33 sections
Butalbital, Acetaminophen, Caffeine and Codeine Phosphate HUMAN PRESCRIPTION DRUG LABEL 4 0054-3000 CAPSULE 40 mg ORAL ANDA 33 sections
ExcedrinExtra Strength Pain Reliever HUMAN OTC DRUG LABEL 3 0067-2000 TABLET, FILM COATED 65 mg ORAL OTC monograph not final 13 sections
ExcedrinExtra Strength Pain Reliever HUMAN OTC DRUG LABEL 3 0067-2000 TABLET, FILM COATED 65 mg ORAL OTC monograph not final 13 sections
ExcedrinExtra Strength Pain Reliever HUMAN OTC DRUG LABEL 3 0067-2001 TABLET, FILM COATED 65 mg ORAL OTC monograph not final 15 sections
ExcedrinExtra Strength Pain Reliever HUMAN OTC DRUG LABEL 3 0067-2001 TABLET, FILM COATED 65 mg ORAL OTC monograph not final 15 sections
ExcedrinExtra Strength Geltabs HUMAN OTC DRUG LABEL 3 0067-2021 TABLET, COATED 65 mg ORAL OTC monograph not final 14 sections
ExcedrinMigraine Geltabs HUMAN OTC DRUG LABEL 3 0067-2035 TABLET, COATED 65 mg ORAL NDA 14 sections
EXCEDRINMIGRAINE HUMAN OTC DRUG LABEL 3 0067-2039 TABLET, FILM COATED 65 mg ORAL NDA 15 sections
EXCEDRINMIGRAINE HUMAN OTC DRUG LABEL 3 0067-2039 TABLET, FILM COATED 65 mg ORAL NDA 15 sections
ExcedrinMigraine HUMAN OTC DRUG LABEL 3 0067-2040 TABLET, FILM COATED 65 mg ORAL NDA 16 sections
ExcedrinMigraine HUMAN OTC DRUG LABEL 3 0067-2040 TABLET, FILM COATED 65 mg ORAL NDA 16 sections
ExcedrinTension Headache HUMAN OTC DRUG LABEL 2 0067-8139 TABLET, FILM COATED 65 mg ORAL OTC monograph not final 15 sections
EXCEDRINMIGRAINE HUMAN OTC DRUG LABEL 3 0067-8201 TABLET, FILM COATED 65 mg ORAL NDA 15 sections
EXCEDRINMIGRAINE HUMAN OTC DRUG LABEL 3 0067-8201 TABLET, FILM COATED 65 mg ORAL NDA 15 sections
ExcedrinExtra Strength Pain Reliever HUMAN OTC DRUG LABEL 3 0067-8202 TABLET, FILM COATED 65 mg ORAL OTC monograph not final 15 sections
ExcedrinExtra Strength Pain Reliever HUMAN OTC DRUG LABEL 3 0067-8202 TABLET, FILM COATED 65 mg ORAL OTC monograph not final 15 sections
ExcedrinExtra Strength Pain Reliever HUMAN OTC DRUG LABEL 3 0067-8203 TABLET, FILM COATED 65 mg ORAL OTC monograph not final 15 sections
good sense migraine formula HUMAN OTC DRUG LABEL 3 0113-0374 TABLET, FILM COATED 65 mg ORAL ANDA 15 sections
good sense migraine formula HUMAN OTC DRUG LABEL 3 0113-0374 TABLET, FILM COATED 65 mg ORAL ANDA 15 sections
good sense stay awake HUMAN OTC DRUG LABEL 1 0113-0409 TABLET 200 mg ORAL OTC monograph final 14 sections
good sense migraine formula HUMAN OTC DRUG LABEL 3 0113-1619 TABLET, FILM COATED 65 mg ORAL ANDA 15 sections
good sense headache relief HUMAN OTC DRUG LABEL 3 0113-1855 TABLET, FILM COATED 65 mg ORAL OTC monograph not final 15 sections
basic care migraine relief HUMAN OTC DRUG LABEL 3 0113-7374 TABLET, FILM COATED 65 mg ORAL ANDA 15 sections
PANADOLExtra HUMAN OTC DRUG LABEL 2 0135-0620 TABLET, FILM COATED 65 mg ORAL OTC monograph not final 16 sections
Butalbital, Acetaminophen, and Caffeine HUMAN PRESCRIPTION DRUG LABEL 3 0143-0170 CAPSULE 40 mg ORAL ANDA 26 sections