iron 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4277 7439-89-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • iron
  • elemental iron (as carbonyl iron)
A metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN.
  • Molecular weight: 55.85
  • Formula: Fe
  • CLOGP: -1.32
  • LIPINSKI: None
  • HAC: 0
  • HDO: 0
  • TPSA:
  • ALOGS:
  • ROTB: 0

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Haemoglobin decreased 122.14 10.03 398 64054 126818 50413854
Blood iron decreased 109.80 10.03 102 64350 11513 50529159
Hand deformity 103.39 10.03 6 64446 100193 50440479
Glossodynia 95.82 10.03 16 64436 115553 50425119
Anaemia 81.85 10.03 576 63876 251880 50288792
Synovitis 78.09 10.03 30 64422 123835 50416837
Exposure during pregnancy 77.14 10.03 332 64120 120683 50419989
Contraindicated product administered 75.91 10.03 48 64404 148910 50391762
Drug ineffective 73.78 10.03 679 63773 818654 49722018
Pericarditis 72.06 10.03 8 64444 78681 50461991
Premature labour 70.64 10.03 80 64372 11396 50529276
Heavy menstrual bleeding 69.21 10.03 92 64360 15445 50525227
Colitis ulcerative 67.81 10.03 95 64357 16759 50523913
Systemic lupus erythematosus 66.72 10.03 49 64403 140573 50400099
Drug intolerance 61.44 10.03 116 64336 218988 50321684
Treatment failure 54.37 10.03 57 64395 137580 50403092
Helicobacter infection 51.18 10.03 3 64449 49699 50490973
Product dose omission issue 50.20 10.03 403 64049 183435 50357237
Toxicity to various agents 49.25 10.03 125 64327 212374 50328298
Frequent bowel movements 48.08 10.03 73 64379 13845 50526827
Hair follicle tumour benign 47.26 10.03 18 64434 369 50540303
Weight decreased 46.98 10.03 459 63993 220786 50319886
Drug abuse 45.95 10.03 10 64442 59836 50480836
Premature delivery 45.39 10.03 96 64356 23567 50517105
Transfusion 43.61 10.03 67 64385 12838 50527834
Joint swelling 43.54 10.03 163 64289 245123 50295549
Vaginal haemorrhage 42.99 10.03 96 64356 24455 50516217
Allergy to metals 42.21 10.03 18 64434 499 50540173
Haematochezia 42.07 10.03 129 64323 39753 50500919
Drug interaction 41.34 10.03 124 64328 199497 50341175
Therapeutic product effect decreased 39.01 10.03 71 64381 135979 50404693
Rheumatoid factor positive 38.95 10.03 8 64444 49851 50490821
Intentional overdose 37.97 10.03 16 64436 62488 50478184
Hepatic enzyme increased 37.37 10.03 74 64378 137306 50403366
Discomfort 37.32 10.03 50 64402 108330 50432342
Uterine leiomyoma 35.56 10.03 47 64405 7844 50532828
Hypersensitivity 34.98 10.03 148 64304 215013 50325659
Mineral supplementation 34.03 10.03 17 64435 682 50539990
Arthropathy 33.47 10.03 97 64355 157809 50382863
Clostridium difficile infection 33.36 10.03 89 64363 25350 50515322
Fluid retention 33.03 10.03 140 64312 50509 50490163
Irritable bowel syndrome 31.51 10.03 13 64439 51428 50489244
Wound 31.42 10.03 54 64398 105740 50434932
Folliculitis 31.26 10.03 6 64446 39219 50501453
Crohn's disease 30.85 10.03 34 64418 4699 50535973
Alopecia 29.95 10.03 186 64266 244861 50295811
Device dislocation 29.91 10.03 77 64375 21469 50519203
Overdose 29.52 10.03 51 64401 99676 50440996
Device expulsion 29.26 10.03 92 64360 28730 50511942
Gastrointestinal haemorrhage 28.98 10.03 176 64276 73145 50467527
Muscle injury 28.90 10.03 6 64446 37105 50503567
Therapeutic reaction time decreased 28.34 10.03 19 64433 1333 50539339
Febrile neutropenia 27.96 10.03 51 64401 97616 50443056
Diarrhoea 27.73 10.03 961 63491 587515 49953157
Complications of bone marrow transplant 27.72 10.03 13 64439 453 50540219
Swelling 27.48 10.03 147 64305 200725 50339947
Caesarean section 27.21 10.03 61 64391 15578 50525094
Neutropenia 27.10 10.03 97 64355 147868 50392804
Full blood count abnormal 26.89 10.03 78 64374 23310 50517362
Sleep disorder due to general medical condition, insomnia type 26.85 10.03 4 64448 31443 50509229
Ill-defined disorder 25.96 10.03 19 64433 54635 50486037
Abdominal pain 25.65 10.03 433 64019 235795 50304877
Hepatosplenic T-cell lymphoma 24.85 10.03 13 64439 575 50540097
Poor venous access 24.71 10.03 46 64406 10294 50530378
Device placement issue 23.45 10.03 14 64438 802 50539870
Iodine allergy 22.71 10.03 13 64439 688 50539984
Infusion related reaction 22.67 10.03 125 64327 169432 50371240
Maternal exposure during breast feeding 22.30 10.03 24 64428 3230 50537442
Chronic disease 22.13 10.03 7 64445 80 50540592
Gastrointestinal tract mucosal pigmentation 22.12 10.03 12 64440 572 50540100
Small intestine ulcer 21.91 10.03 10 64442 327 50540345
Flushing 21.69 10.03 153 64299 66862 50473810
Normal newborn 21.57 10.03 34 64418 6657 50534015
Muscle spasms 21.24 10.03 249 64203 125304 50415368
Hyponatraemia 21.14 10.03 58 64394 96081 50444591
Blood pressure fluctuation 21.06 10.03 96 64356 35727 50504945
Fatigue 20.98 10.03 1101 63351 706500 49834172
Inappropriate schedule of product administration 20.96 10.03 160 64292 71671 50469001
Cardiac arrest 20.30 10.03 48 64404 83603 50457069
Off label use 20.15 10.03 766 63686 473660 50067012
Drug hypersensitivity 19.88 10.03 214 64238 250796 50289876
Vitamin D decreased 19.60 10.03 37 64415 8369 50532303
Blood growth hormone increased 19.44 10.03 10 64442 427 50540245
Headache 18.55 10.03 805 63647 505730 50034942
Complication of device insertion 18.52 10.03 30 64422 6011 50534661
Blister 18.43 10.03 52 64400 85366 50455306
Empty sella syndrome 18.24 10.03 5 64447 33 50540639
Haemoglobin abnormal 17.94 10.03 25 64427 4387 50536285
Faeces discoloured 17.79 10.03 53 64399 16071 50524601
Drug reaction with eosinophilia and systemic symptoms 17.71 10.03 7 64445 28417 50512255
Dizziness 17.35 10.03 570 63882 345799 50194873
Red blood cell count decreased 17.23 10.03 87 64365 33748 50506924
Full blood count decreased 17.15 10.03 65 64387 22281 50518391
Intermenstrual bleeding 17.15 10.03 31 64421 6783 50533889
Delayed haemolytic transfusion reaction 17.00 10.03 3 64449 0 50540672
Rash 16.95 10.03 426 64026 437045 50103627
Dysmenorrhoea 16.94 10.03 21 64431 3289 50537383
Chills 16.90 10.03 193 64259 96494 50444178
Blood cholesterol increased 16.55 10.03 28 64424 55187 50485485
Iron deficiency 16.48 10.03 28 64424 5834 50534838
Pregnancy 16.45 10.03 78 64374 29499 50511173
Drug level below therapeutic 16.43 10.03 22 64430 3718 50536954
Natural killer cell count 16.25 10.03 4 64448 16 50540656
Amegakaryocytic thrombocytopenia 16.25 10.03 4 64448 16 50540656
Hypervolaemia 16.25 10.03 70 64382 25429 50515243
Gastric bypass 16.22 10.03 14 64438 1434 50539238
Arthritis infective 16.19 10.03 27 64425 5542 50535130
Uterine perforation 15.91 10.03 29 64423 6386 50534286
Acute kidney injury 15.89 10.03 200 64252 227858 50312814
Intestinal obstruction 15.73 10.03 71 64381 26312 50514360
Suicide attempt 15.72 10.03 26 64426 51706 50488966
C-reactive protein abnormal 15.52 10.03 8 64444 27801 50512871
Intestinal resection 15.42 10.03 17 64435 2350 50538322
Hospitalisation 15.39 10.03 143 64309 67794 50472878
Illness 15.35 10.03 67 64385 24473 50516199
Defaecation urgency 15.13 10.03 19 64433 3014 50537658
Stomatitis 15.07 10.03 72 64380 101272 50439400
Malabsorption 15.07 10.03 21 64431 3685 50536987
Macrophages increased 15.06 10.03 4 64448 23 50540649
Abdominal discomfort 14.74 10.03 207 64245 231434 50309238
Acute lung injury 14.67 10.03 13 64439 1380 50539292
Iron deficiency anaemia 14.64 10.03 51 64401 16783 50523889
Osteonecrosis of jaw 14.57 10.03 12 64440 32514 50508158
Eosinophilia 14.55 10.03 3 64449 18649 50522023
Rhabdomyolysis 14.48 10.03 17 64435 39010 50501662
Toxoplasmosis 14.48 10.03 13 64439 1404 50539268
Mucosal inflammation 14.34 10.03 18 64434 40124 50500548
Asthenia 14.20 10.03 518 63934 318524 50222148
Confusional state 14.12 10.03 160 64292 185768 50354904
Heart rate increased 13.86 10.03 155 64297 77095 50463577
Hepatic function abnormal 13.50 10.03 13 64439 32668 50508004
Uterine atony 13.45 10.03 6 64446 186 50540486
Small intestinal obstruction 13.39 10.03 48 64404 16020 50524652
Uterine haemorrhage 13.37 10.03 19 64433 3396 50537276
Depressed level of consciousness 13.26 10.03 29 64423 51924 50488748
Faecal calprotectin increased 13.22 10.03 15 64437 2140 50538532
Device breakage 13.12 10.03 34 64418 9513 50531159
Dyspnoea 13.08 10.03 836 63616 546772 49993900
Foreign body in reproductive tract 13.05 10.03 8 64444 481 50540191
Small intestinal stenosis 12.94 10.03 8 64444 488 50540184
Embedded device 12.94 10.03 17 64435 2820 50537852
Porphyria acute 12.93 10.03 8 64444 489 50540183
Molluscum contagiosum 12.88 10.03 6 64446 206 50540466
Haemorrhage 12.88 10.03 114 64338 53327 50487345
Sulphaemoglobinaemia 12.85 10.03 3 64449 9 50540663
Coma 12.74 10.03 34 64418 56845 50483827
Nephrogenic systemic fibrosis 12.62 10.03 21 64431 4301 50536371
Premature separation of placenta 12.61 10.03 13 64439 1665 50539007
Incorrect dose administered 12.57 10.03 105 64347 48309 50492363
Sprue-like enteropathy 12.55 10.03 8 64444 515 50540157
Abdominal abscess 12.42 10.03 20 64432 3988 50536684
Rhinorrhoea 12.41 10.03 110 64342 51473 50489199
Urinary tract infection 12.33 10.03 373 64079 223647 50317025
Completed suicide 12.30 10.03 108 64344 131781 50408891
Postpartum haemorrhage 12.13 10.03 13 64439 1741 50538931
Haematocrit decreased 11.99 10.03 81 64371 34895 50505777
Appetite disorder 11.95 10.03 25 64427 6089 50534583
Alanine aminotransferase increased 11.88 10.03 65 64387 88294 50452378
Rectal haemorrhage 11.87 10.03 87 64365 38471 50502201
Leukopenia 11.87 10.03 45 64407 67483 50473189
Complication of device removal 11.85 10.03 20 64432 4144 50536528
Rheumatoid arthritis 11.84 10.03 184 64268 202366 50338306
Nasal congestion 11.78 10.03 108 64344 51012 50489660
Platelet count increased 11.75 10.03 43 64409 14497 50526175
Abnormal faeces 11.74 10.03 20 64432 4176 50536496
Premature rupture of membranes 11.74 10.03 21 64431 4559 50536113
Plasma cell myeloma 11.62 10.03 74 64378 31248 50509424
Pulmonary arterial hypertension 11.61 10.03 54 64398 20265 50520407
Hip arthroplasty 11.56 10.03 13 64439 30416 50510256
Vascular stenosis 11.44 10.03 6 64446 267 50540405
Blood albumin decreased 11.43 10.03 40 64412 13196 50527476
Pre-eclampsia 11.42 10.03 29 64423 8015 50532657
Multiple organ dysfunction syndrome 11.34 10.03 30 64422 50307 50490365
Skin warm 11.23 10.03 21 64431 4714 50535958
Serotonin syndrome 11.21 10.03 9 64443 24704 50515968
Respiratory arrest 11.21 10.03 13 64439 29996 50510676
Hyperparathyroidism secondary 11.14 10.03 11 64441 1339 50539333
Thyroid adenoma 11.12 10.03 5 64447 158 50540514
Polymenorrhoea 10.97 10.03 10 64442 1101 50539571
Eosinophilic pneumonia chronic 10.78 10.03 5 64447 170 50540502
Ileostomy 10.76 10.03 10 64442 1128 50539544
Heart rate irregular 10.73 10.03 51 64401 19309 50521363
Drug specific antibody present 10.70 10.03 17 64435 3351 50537321
Acute myeloid leukaemia 10.63 10.03 3 64449 15071 50525601
Heart valve replacement 10.61 10.03 7 64445 478 50540194
Flatulence 10.57 10.03 69 64383 29389 50511283
Sterile pyuria 10.44 10.03 3 64449 24 50540648
Agitation 10.44 10.03 34 64418 53350 50487322
Gastrointestinal stromal tumour 10.43 10.03 9 64443 922 50539750
Bronchospasm 10.40 10.03 3 64449 14851 50525821
Wound infection bacterial 10.34 10.03 7 64445 499 50540173
Anal fissure 10.32 10.03 16 64436 3089 50537583
Cytomegalovirus infection 10.28 10.03 5 64447 17957 50522715
Rash macular 10.12 10.03 50 64402 19227 50521445
Septic shock 10.11 10.03 38 64414 57137 50483535
Refractory cytopenia with unilineage dysplasia 10.05 10.03 7 64445 523 50540149
Shock 10.04 10.03 7 64445 20643 50520029

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Colitis ulcerative 122.68 12.12 97 26166 12672 29535592
Fatigue 73.32 12.12 506 25757 316315 29231949
Diarrhoea 59.32 12.12 500 25763 332198 29216066
Haematochezia 55.92 12.12 110 26153 36873 29511391
Blood iron decreased 49.75 12.12 37 26226 4411 29543853
Drug abuse 47.81 12.12 7 26256 79876 29468388
Haemoglobin decreased 47.24 12.12 206 26057 108169 29440095
Full blood count decreased 43.62 12.12 62 26201 15930 29532334
Abdominal pain 39.03 12.12 229 26034 135128 29413136
Frequent bowel movements 36.46 12.12 43 26220 9196 29539068
Toxicity to various agents 35.88 12.12 62 26201 173599 29374665
Febrile neutropenia 33.74 12.12 30 26233 112210 29436054
Exposure during pregnancy 32.42 12.12 39 26224 8515 29539749
Clostridium difficile infection 31.99 12.12 54 26209 16087 29532177
Crohn's disease 31.37 12.12 24 26239 2985 29545279
Asthenia 30.83 12.12 309 25954 214941 29333323
Device interaction 30.04 12.12 13 26250 542 29547722
Gastrointestinal haemorrhage 28.60 12.12 143 26120 79390 29468874
Faeces discoloured 28.25 12.12 46 26217 13305 29534959
Drug interaction 28.20 12.12 86 26177 197299 29350965
Nephrogenic systemic fibrosis 27.66 12.12 25 26238 3917 29544347
Faecal calprotectin increased 27.00 12.12 17 26246 1544 29546720
Anaemia 26.16 12.12 283 25980 200668 29347596
Weight decreased 25.76 12.12 225 26038 150680 29397584
Product dose omission issue 25.17 12.12 159 26104 96224 29452040
Rhabdomyolysis 23.98 12.12 12 26251 60796 29487468
Interstitial lung disease 23.36 12.12 11 26252 57707 29490557
Acute kidney injury 22.89 12.12 140 26123 265127 29283137
Constipation 22.57 12.12 176 26087 113984 29434280
Blood pressure fluctuation 21.83 12.12 52 26211 19842 29528422
Normochromic normocytic anaemia 21.45 12.12 21 26242 3637 29544627
Muscle spasms 21.30 12.12 114 26149 64968 29483296
Thrombosis 20.40 12.12 84 26179 42961 29505303
Mineral supplementation 20.12 12.12 6 26257 82 29548182
Iron deficiency anaemia 19.17 12.12 31 26232 8911 29539353
Aplasia pure red cell 19.13 12.12 24 26239 5467 29542797
Mucous stools 18.72 12.12 12 26251 1125 29547139
Intestinal resection 18.25 12.12 13 26250 1449 29546815
Agitated depression 17.83 12.12 7 26256 227 29548037
Intentional overdose 17.78 12.12 6 26257 38522 29509742
Weight increased 16.72 12.12 121 26142 76546 29471718
Gastroduodenal haemorrhage 16.68 12.12 6 26257 152 29548112
Diet noncompliance 16.60 12.12 6 26257 154 29548110
Hospitalisation 16.03 12.12 82 26181 45906 29502358
Flatulence 15.99 12.12 43 26220 17666 29530598
Supraventricular tachycardia 15.66 12.12 30 26233 9854 29538410
Haemorrhage 15.46 12.12 80 26183 44992 29503272
Gastrointestinal inflammation 15.32 12.12 16 26247 2992 29545272
Nasopharyngitis 15.29 12.12 98 26165 59567 29488697
Faecal calprotectin abnormal 15.15 12.12 6 26257 199 29548065
Inflammatory bowel disease 14.94 12.12 14 26249 2297 29545967
Spondylitis 14.60 12.12 10 26253 1047 29547217
Suicide attempt 14.59 12.12 6 26257 34104 29514160
Completed suicide 14.58 12.12 37 26226 90209 29458055
Aspartate aminotransferase increased 14.56 12.12 19 26244 59706 29488558
Probiotic therapy 14.48 12.12 3 26260 7 29548257
Polyneuropathy in malignant disease 14.47 12.12 5 26258 112 29548152
Malaise 14.39 12.12 210 26053 159392 29388872
Skin induration 14.36 12.12 13 26250 2041 29546223
Plasma cell myeloma 14.23 12.12 68 26195 37047 29511217
Fistula 14.12 12.12 20 26243 5119 29543145
Intestinal obstruction 13.74 12.12 43 26220 19234 29529030
Fluid retention 13.64 12.12 49 26214 23511 29524753
Anal ulcer 13.52 12.12 8 26255 650 29547614
Thrombocytopenia 13.31 12.12 68 26195 134755 29413509
Intestinal stenosis 13.30 12.12 12 26251 1876 29546388
Anaemia neonatal 13.17 12.12 6 26257 283 29547981
Meconium abnormal 13.01 12.12 4 26259 61 29548203
Maternal exposure before pregnancy 12.96 12.12 7 26256 477 29547787
Poor venous access 12.95 12.12 15 26248 3146 29545118
Intestinal mucosal hypertrophy 12.83 12.12 4 26259 64 29548200
Heart rate increased 12.59 12.12 68 26195 38870 29509394
Therapeutic response shortened 12.22 12.12 18 26245 4773 29543491
Hip fracture 12.13 12.12 28 26235 10464 29537800
Abdominal distension 12.13 12.12 76 26187 45835 29502429

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Colitis ulcerative 154.76 10.07 156 69864 22872 64405840
Blood iron decreased 119.95 10.07 102 69918 12040 64416672
Haemoglobin decreased 118.57 10.07 472 69548 194591 64234121
Drug abuse 94.93 10.07 15 70005 132359 64296353
Frequent bowel movements 79.89 10.07 99 69921 18206 64410506
Fatigue 79.03 10.07 1194 68826 747536 63681176
Haematochezia 78.41 10.07 202 69818 66171 64362541
Toxicity to various agents 77.67 10.07 175 69845 363338 64065374
Exposure during pregnancy 76.39 10.07 221 69799 77454 64351258
Drug interaction 69.72 10.07 184 69836 361899 64066813
Heavy menstrual bleeding 65.48 10.07 73 69947 12004 64416708
Synovitis 65.09 10.07 14 70006 99076 64329636
Clostridium difficile infection 63.78 10.07 129 69891 36034 64392678
Anaemia 63.52 10.07 659 69361 378021 64050691
Premature delivery 61.81 10.07 88 69932 18501 64410211
Abdominal pain 59.86 10.07 559 69461 311816 64116896
Weight decreased 59.16 10.07 520 69500 285219 64143493
Febrile neutropenia 59.07 10.07 70 69950 187587 64241125
Product dose omission issue 56.21 10.07 383 69637 194364 64234348
Off label use 50.47 10.07 965 69055 631841 63796871
Contraindicated product administered 49.06 10.07 28 69992 107801 64320911
Hair follicle tumour benign 48.01 10.07 18 70002 417 64428295
Device expulsion 47.98 10.07 84 69936 21052 64407660
Neutropenia 47.43 10.07 120 69900 239504 64189208
Mineral supplementation 47.10 10.07 21 69999 766 64427946
Acute kidney injury 46.19 10.07 292 69728 448948 63979764
Gastrointestinal haemorrhage 46.07 10.07 273 69747 132039 64296673
Intentional overdose 45.98 10.07 20 70000 89924 64338788
Faecal calprotectin increased 45.30 10.07 35 69985 3605 64425107
Diarrhoea 45.29 10.07 1064 68956 721640 63707072
Hand deformity 45.24 10.07 7 70013 62764 64365948
Inappropriate schedule of product administration 44.22 10.07 208 69812 92078 64336634
Faeces discoloured 43.26 10.07 90 69930 25639 64403073
Poor venous access 41.60 10.07 59 69961 12358 64416354
Blood pressure fluctuation 41.16 10.07 137 69883 51734 64376978
Hepatic function abnormal 40.41 10.07 10 70010 64303 64364409
Fluid retention 39.20 10.07 148 69872 59458 64369254
Transfusion 38.90 10.07 70 69950 17924 64410788
Pericarditis 38.74 10.07 10 70010 62506 64366206
Rhabdomyolysis 38.70 10.07 26 69994 91700 64337012
Device dislocation 37.88 10.07 76 69944 21102 64407610
Vaginal haemorrhage 37.73 10.07 72 69948 19272 64409440
Overdose 36.36 10.07 74 69946 159492 64269220
Treatment failure 36.29 10.07 44 69976 116772 64311940
Premature labour 32.91 10.07 41 69979 7579 64421133
Full blood count decreased 32.29 10.07 74 69946 22508 64406204
Flushing 31.82 10.07 169 69851 78479 64350233
Therapeutic reaction time decreased 31.81 10.07 22 69998 1910 64426802
Drug intolerance 31.42 10.07 102 69918 187890 64240822
Intestinal resection 30.76 10.07 26 69994 3042 64425670
Uterine leiomyoma 30.05 10.07 33 69987 5336 64423376
Caesarean section 29.84 10.07 48 69972 11226 64417486
Hospitalisation 29.34 10.07 160 69860 75047 64353665
Nephrogenic systemic fibrosis 29.20 10.07 34 69986 5858 64422854
Glossodynia 29.14 10.07 17 70003 64679 64364033
Interstitial lung disease 28.10 10.07 39 69981 97693 64331019
Duodenal ulcer perforation 27.01 10.07 3 70017 34622 64394090
Device placement issue 26.71 10.07 14 70006 732 64427980
Complication of device insertion 26.66 10.07 30 69990 4982 64423730
Gastrointestinal tract mucosal pigmentation 26.53 10.07 15 70005 912 64427800
Suicide attempt 26.29 10.07 23 69997 70984 64357728
Iron deficiency anaemia 26.23 10.07 67 69953 21822 64406890
Chronic disease 26.20 10.07 8 70012 96 64428616
Dizziness 26.12 10.07 631 69389 429532 63999180
Intentional product use issue 25.97 10.07 185 69835 95179 64333533
Complications of bone marrow transplant 25.87 10.07 13 70007 622 64428090
Hyponatraemia 25.82 10.07 79 69941 148260 64280452
Agitation 25.67 10.07 35 69985 88332 64340380
Cardiac arrest 25.45 10.07 84 69936 153980 64274732
Helicobacter infection 24.03 10.07 6 70014 38356 64390356
Haemoglobin abnormal 23.86 10.07 31 69989 5973 64422739
Muscle spasms 23.83 10.07 246 69774 140777 64287935
Flatulence 23.81 10.07 89 69931 35577 64393135
Anal fissure 23.66 10.07 28 69992 4908 64423804
Dyspnoea 23.47 10.07 978 69042 717696 63711016
Completed suicide 23.45 10.07 145 69875 224269 64204443
Drug reaction with eosinophilia and systemic symptoms 23.37 10.07 15 70005 54202 64374510
Asthenia 23.35 10.07 619 69401 427425 64001287
Drug level below therapeutic 23.15 10.07 34 69986 7350 64421362
Leukopenia 23.01 10.07 47 69973 101195 64327517
Hepatosplenic T-cell lymphoma 22.72 10.07 13 70007 809 64427903
Condition aggravated 22.19 10.07 545 69475 371881 64056831
Intestinal obstruction 22.14 10.07 88 69932 36198 64392514
Maternal exposure during breast feeding 22.12 10.07 18 70002 1998 64426714
Hepatic enzyme increased 22.05 10.07 70 69950 129873 64298839
Eosinophilia 21.91 10.07 7 70013 38069 64390643
Headache 21.69 10.07 739 69281 528728 63899984
Mucous stools 21.67 10.07 22 69998 3251 64425461
Malaise 21.60 10.07 573 69447 395674 64033038
Uterine perforation 21.51 10.07 29 69991 5791 64422921
Urinary tract infection 21.46 10.07 362 69658 231234 64197478
Coma 21.37 10.07 39 69981 87576 64341136
Heart rate increased 21.10 10.07 181 69839 98494 64330218
Normal newborn 20.78 10.07 28 69992 5589 64423123
Multiple organ dysfunction syndrome 20.65 10.07 50 69970 101363 64327349
Drug ineffective 20.46 10.07 727 69293 839520 63589192
Blood creatine phosphokinase increased 20.46 10.07 20 70000 58538 64370174
Weight increased 20.33 10.07 335 69685 213013 64215699
Neurotoxicity 19.87 10.07 3 70017 27401 64401311
Full blood count abnormal 19.65 10.07 74 69946 29683 64399029
Serotonin syndrome 19.65 10.07 9 70011 39273 64389439
Cerebral infarction 19.62 10.07 10 70010 41034 64387678
Alanine aminotransferase increased 19.55 10.07 81 69939 138950 64289762
Maternal exposure during pregnancy 19.53 10.07 174 69846 95710 64333002
Rheumatoid factor positive 19.11 10.07 7 70013 34931 64393781
Drug level decreased 19.06 10.07 40 69980 11463 64417249
Mucosal inflammation 18.98 10.07 24 69996 62560 64366152
Osteonecrosis of jaw 18.60 10.07 10 70010 39815 64388897
Coronary artery disease 18.51 10.07 23 69997 60410 64368302
Rhinorrhoea 18.51 10.07 120 69900 59849 64368863
Abnormal faeces 18.40 10.07 27 69993 5832 64422880
Allergy to metals 18.24 10.07 9 70011 414 64428298
Transferrin saturation decreased 18.23 10.07 11 70009 756 64427956
Intermenstrual bleeding 18.13 10.07 25 69995 5100 64423612
Defaecation urgency 18.09 10.07 22 69998 3967 64424745
Drug specific antibody present 18.02 10.07 25 69995 5129 64423583
Aspartate aminotransferase increased 17.98 10.07 68 69952 119720 64308992
Systemic lupus erythematosus 17.66 10.07 36 69984 77576 64351136
Malignant neoplasm progression 17.65 10.07 63 69957 112808 64315904
Gamma-glutamyltransferase increased 17.61 10.07 16 70004 48494 64380218
Hip fracture 17.57 10.07 67 69953 27032 64401680
Premature rupture of membranes 17.55 10.07 21 69999 3723 64424989
Serum ferritin 17.48 10.07 3 70017 0 64428712
Product use issue 17.44 10.07 246 69774 151469 64277243
Ischaemic stroke 17.32 10.07 5 70015 29030 64399682
Arthropod bite 16.96 10.07 28 69992 6693 64422019
Small intestinal stenosis 16.92 10.07 10 70010 661 64428051
Iron deficiency 16.91 10.07 29 69991 7148 64421564
Natural killer cell count 16.89 10.07 4 70016 16 64428696
Rectal haemorrhage 16.87 10.07 120 69900 61697 64367015
Muscle injury 16.82 10.07 4 70016 26433 64402279
Amegakaryocytic thrombocytopenia 16.69 10.07 4 70016 17 64428695
Sleep disorder due to general medical condition, insomnia type 16.67 10.07 4 70016 26266 64402446
Folliculitis 16.49 10.07 6 70014 30071 64398641
Complication of device removal 16.38 10.07 19 70001 3261 64425451
Heart valve replacement 16.17 10.07 10 70010 718 64427994
Sopor 16.12 10.07 6 70014 29655 64399057
Postpartum haemorrhage 16.05 10.07 13 70007 1434 64427278
Abdominal pain upper 15.99 10.07 273 69747 174757 64253955
Haemorrhage 15.64 10.07 143 69877 79208 64349504
Incorrect dose administered 15.46 10.07 116 69904 60649 64368063
Lactic acidosis 15.27 10.07 27 69993 61383 64367329
Nasopharyngitis 15.18 10.07 298 69722 195775 64232937
Drug hypersensitivity 15.18 10.07 175 69845 237640 64191072
Depressed level of consciousness 15.16 10.07 42 69978 81394 64347318
Gastric bypass 15.08 10.07 11 70009 1039 64427673
Pulmonary arterial hypertension 15.06 10.07 61 69959 25306 64403406
Neutrophil count decreased 14.99 10.07 39 69981 77157 64351555
Cholestasis 14.91 10.07 16 70004 44856 64383856
Uterine atony 14.91 10.07 6 70014 169 64428543
Malabsorption 14.86 10.07 21 69999 4382 64424330
Accidental overdose 14.85 10.07 9 70011 33548 64395164
Agitated depression 14.82 10.07 7 70013 292 64428420
Nasal congestion 14.68 10.07 113 69907 59545 64369167
Constipation 14.67 10.07 339 69681 228998 64199714
Hypervolaemia 14.62 10.07 81 69939 38204 64390508
Internal haemorrhage 14.29 10.07 28 69992 7639 64421073
Dyskinesia 14.29 10.07 13 70007 39375 64389337
Skin induration 14.22 10.07 20 70000 4155 64424557
Acute myeloid leukaemia 14.20 10.07 6 70014 27457 64401255
Small intestine ulcer 14.15 10.07 9 70011 679 64428033
Polymenorrhoea 14.14 10.07 10 70010 900 64427812
Device interaction 14.03 10.07 9 70011 689 64428023
Device breakage 13.99 10.07 30 69990 8725 64419987
Therapeutic product effect decreased 13.96 10.07 71 69949 115280 64313432
Irritable bowel syndrome 13.96 10.07 12 70008 37357 64391355
Bone marrow failure 13.92 10.07 19 70001 47933 64380779
Delayed haemolytic transfusion reaction 13.88 10.07 3 70017 7 64428705
Maternal exposure before pregnancy 13.87 10.07 18 70002 3465 64425247
Embedded device 13.84 10.07 16 70004 2736 64425976
Red blood cell count decreased 13.83 10.07 95 69925 48291 64380421
Cytomegalovirus infection 13.83 10.07 12 70008 37187 64391525
Neuroleptic malignant syndrome 13.68 10.07 5 70015 24991 64403721
Retching 13.65 10.07 42 69978 15214 64413498
Arthritis infective 13.50 10.07 26 69994 7004 64421708
Dysmenorrhoea 13.37 10.07 15 70005 2482 64426230
Electrocardiogram QT prolonged 13.33 10.07 43 69977 79405 64349307
Peritonitis bacterial 13.33 10.07 30 69990 9013 64419699
Sulphaemoglobinaemia 13.33 10.07 3 70017 9 64428703
Rash maculo-papular 13.28 10.07 19 70001 47007 64381705
Thrombosis 13.27 10.07 126 69894 70516 64358196
Pancytopenia 13.25 10.07 96 69924 143213 64285499
Illness 13.22 10.07 53 69967 21885 64406827
Pre-eclampsia 13.16 10.07 24 69996 6207 64422505
Cerebral haemorrhage 13.13 10.07 22 69998 51068 64377644
Bradycardia 13.07 10.07 75 69945 118144 64310568
Vitamin D decreased 13.05 10.07 27 69993 7660 64421052
Pregnancy 13.05 10.07 51 69969 20814 64407898
Thrombocytopenia 13.02 10.07 168 69852 223633 64205079
Transferrin saturation increased 13.02 10.07 5 70015 124 64428588
Calciphylaxis 13.01 10.07 17 70003 3295 64425417
Inappropriate antidiuretic hormone secretion 13 10.07 4 70016 22285 64406427
Angioedema 12.97 10.07 30 69990 61791 64366921
Hypokalaemia 12.60 10.07 79 69941 121824 64306888
C-reactive protein abnormal 12.57 10.07 8 70012 29039 64399673
Heart rate irregular 12.55 10.07 61 69959 27352 64401360
Appetite disorder 12.54 10.07 24 69996 6437 64422275
Hyperparathyroidism secondary 12.49 10.07 14 70006 2316 64426396
Ileostomy closure 12.48 10.07 5 70015 139 64428573
Sedation 12.47 10.07 16 70004 41446 64387266
Blood growth hormone increased 12.45 10.07 8 70012 614 64428098
Gastroduodenal haemorrhage 12.43 10.07 6 70014 263 64428449
Joint swelling 12.41 10.07 162 69858 215220 64213492
Extrapyramidal disorder 12.36 10.07 3 70017 19549 64409163
Agranulocytosis 12.29 10.07 14 70006 38215 64390497
Blood pressure increased 12.27 10.07 259 69761 172293 64256419
Chronic kidney disease 12.25 10.07 106 69914 57813 64370899
Epilepsy 12.24 10.07 11 70009 33520 64395192
Cardio-respiratory arrest 12.23 10.07 60 69960 98333 64330379
Neutropenic sepsis 12.17 10.07 5 70015 23267 64405445
Bowel movement irregularity 12.13 10.07 20 70000 4773 64423939
Toxic skin eruption 12.11 10.07 3 70017 19281 64409431
Premature separation of placenta 12.10 10.07 10 70010 1134 64427578
Therapeutic response shortened 12.05 10.07 31 69989 10139 64418573
Polyneuropathy in malignant disease 11.97 10.07 5 70015 155 64428557
Foreign body in reproductive tract 11.97 10.07 7 70013 454 64428258
Intestinal stenosis 11.86 10.07 16 70004 3198 64425514
Labour complication 11.82 10.07 4 70016 68 64428644
Respiratory arrest 11.70 10.07 25 69995 52960 64375752
Arthropathy 11.69 10.07 80 69940 120887 64307825
Inflammatory bowel disease 11.57 10.07 19 70001 4519 64424193
Haematocrit decreased 11.55 10.07 100 69920 54555 64374157
Ileostomy 11.51 10.07 10 70010 1214 64427498
Empty sella syndrome 11.51 10.07 4 70016 74 64428638
Kidney infection 11.48 10.07 44 69976 17794 64410918
Chills 11.43 10.07 211 69809 137053 64291659
Porphyria acute 11.39 10.07 8 70012 712 64428000
Injection site pain 11.37 10.07 177 69843 111231 64317481
Uterine haemorrhage 11.33 10.07 14 70006 2565 64426147
Aplasia pure red cell 11.17 10.07 24 69996 6990 64421722
Live birth 11.12 10.07 32 69988 11172 64417540
Diarrhoea haemorrhagic 11.08 10.07 32 69988 11195 64417517
Probiotic therapy 11.03 10.07 3 70017 23 64428689
Gastrointestinal bacterial overgrowth 10.87 10.07 6 70014 348 64428364
Respiratory depression 10.78 10.07 6 70014 23437 64405275
Influenza 10.78 10.07 169 69851 106362 64322350
Transaminases increased 10.74 10.07 20 70000 44574 64384138
Pelvic pain 10.67 10.07 31 69989 10879 64417833
Plasma cell myeloma 10.64 10.07 86 69934 45989 64382723
Hyperphosphataemia 10.61 10.07 17 70003 3964 64424748
Confusional state 10.52 10.07 210 69810 260934 64167778
Pancreatitis acute 10.51 10.07 19 70001 42836 64385876
Toxic epidermal necrolysis 10.51 10.07 15 70005 37151 64391561
Dyschezia 10.46 10.07 13 70007 2397 64426315
Tumour lysis syndrome 10.45 10.07 4 70016 19436 64409276
Ill-defined disorder 10.39 10.07 20 70000 44032 64384680
Posterior reversible encephalopathy syndrome 10.37 10.07 6 70014 22940 64405772
Abscess 10.35 10.07 45 69975 19259 64409453
Platelet count increased 10.35 10.07 44 69976 18652 64410060
Toxoplasmosis 10.31 10.07 13 70007 2431 64426281
Anal ulcer 10.31 10.07 9 70011 1100 64427612
Serum ferritin abnormal 10.30 10.07 6 70014 386 64428326
Hepatocellular injury 10.27 10.07 21 69999 45214 64383498
Blood glucose decreased 10.26 10.07 51 69969 23072 64405640
Disorientation 10.24 10.07 29 69991 55799 64372913
Disseminated intravascular coagulation 10.24 10.07 12 70008 32336 64396376
Heart rate decreased 10.23 10.07 98 69922 54969 64373743
Pyrexia 10.22 10.07 499 69521 558145 63870567
Pain in extremity 10.19 10.07 414 69606 302671 64126041
Oropharyngeal pain 10.17 10.07 144 69876 88723 64339989
Hypersensitivity 10.16 10.07 151 69869 196301 64232411
Preterm premature rupture of membranes 10.10 10.07 9 70011 1130 64427582

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A11AA01 ALIMENTARY TRACT AND METABOLISM
VITAMINS
MULTIVITAMINS, COMBINATIONS
Multivitamins with minerals
ATC B03AE01 BLOOD AND BLOOD FORMING ORGANS
ANTIANEMIC PREPARATIONS
IRON PREPARATIONS
Iron in other combinations
ATC B03AE02 BLOOD AND BLOOD FORMING ORGANS
ANTIANEMIC PREPARATIONS
IRON PREPARATIONS
Iron in other combinations
ATC B03AE03 BLOOD AND BLOOD FORMING ORGANS
ANTIANEMIC PREPARATIONS
IRON PREPARATIONS
Iron in other combinations
ATC B03AE04 BLOOD AND BLOOD FORMING ORGANS
ANTIANEMIC PREPARATIONS
IRON PREPARATIONS
Iron in other combinations
MeSH PA D018977 Micronutrients
MeSH PA D014131 Trace Elements
CHEBI has role CHEBI:27027 trace elements
CHEBI has role CHEBI:76971 Escherichia coli metabolites

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Anemia of prematurity indication 47100003 DOID:11243
Megaloblastic anemia due to folate deficiency indication 85649008 DOID:14026
Iron deficiency anemia indication 87522002
Magnetic resonance imaging of liver indication 241622002
Peptic ulcer contraindication 13200003 DOID:750
Gastroenteritis contraindication 25374005 DOID:2326
Hemosiderosis contraindication 39011001 DOID:12119
Hemolytic anemia contraindication 61261009 DOID:583
Ulcerative colitis contraindication 64766004 DOID:8577
Diverticular disease contraindication 397881000
Hemochromatosis contraindication 399187006 DOID:2352
Repeated Blood Transfusions contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4017653 VUID
N0000146032 NUI
D09736 KEGG_DRUG
4017653 VANDF
4021247 VANDF
4021883 VANDF
C0302583 UMLSCUI
CHEBI:18248 CHEBI
D007501 MESH_DESCRIPTOR_UI
DB01592 DRUGBANK_ID
E1UOL152H7 UNII
23925 PUBCHEM_CID
262150 RXNORM
30874 MMSL
34448 MMSL
6958 MMSL
7441 MMSL
8219 MMSL
NOCODE MMSL
d04432 MMSL
000828 NDDF
007431 NDDF
30729008 SNOMEDCT_US
32954005 SNOMEDCT_US
3829006 SNOMEDCT_US
714781004 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Ferralet 90 HUMAN PRESCRIPTION DRUG LABEL 5 0178-0089 TABLET, FILM COATED 90 mg ORAL unapproved drug other 17 sections
NataFort HUMAN PRESCRIPTION DRUG LABEL 10 0178-0716 TABLET 60 mg ORAL Unapproved drug other 12 sections
CitraNatal Harmony 3.0 HUMAN PRESCRIPTION DRUG LABEL 8 0178-0796 CAPSULE, GELATIN COATED 27 mg ORAL unapproved drug other 10 sections
Citranatal Harmony 2.1 HUMAN PRESCRIPTION DRUG LABEL 2 0178-0797 CAPSULE, GELATIN COATED 29 mg ORAL unapproved drug other 10 sections
CitraNatal 90 DHA HUMAN PRESCRIPTION DRUG LABEL 16 0178-0821 TABLET 85 mg ORAL unapproved drug other 11 sections
CitraNatal 90 DHA HUMAN OTC DRUG LABEL 14 0178-0829 TABLET 90 mg ORAL Unapproved drug other 11 sections
CitraNatal Rx HUMAN PRESCRIPTION DRUG LABEL 13 0178-0858 TABLET 27 mg ORAL Unapproved drug other 12 sections
CitraNatal Rx HUMAN PRESCRIPTION DRUG LABEL 14 0178-0859 TABLET 27 mg ORAL Unapproved drug other 9 sections
CitraNatal Medley HUMAN PRESCRIPTION DRUG LABEL 8 0178-0896 CAPSULE, GELATIN COATED 27 mg ORAL unapproved drug other 10 sections
CitraNatal DHA HUMAN OTC DRUG LABEL 14 0178-0898 TABLET 27 mg ORAL Unapproved drug other 11 sections
VitafolOne HUMAN PRESCRIPTION DRUG LABEL 16 0642-0070 CAPSULE, GELATIN COATED 29 mg ORAL unapproved drug other 14 sections
Vitafol Caplet HUMAN PRESCRIPTION DRUG LABEL 12 0642-0072 CAPSULE 27 mg ORAL UNAPPROVED DRUG OTHER 13 sections
Select OB HUMAN PRESCRIPTION DRUG LABEL 15 0642-0077 TABLET, CHEWABLE 29 mg ORAL UNAPPROVED DRUG OTHER 14 sections
Vitafol OB Caplet HUMAN PRESCRIPTION DRUG LABEL 15 0642-0079 TABLET 65 mg ORAL Unapproved drug other 14 sections
Vitafol Plus HUMAN PRESCRIPTION DRUG LABEL 17 0642-0092 CAPSULE, LIQUID FILLED 27 mg ORAL UNAPPROVED DRUG OTHER 13 sections
Vitafol Ultra HUMAN PRESCRIPTION DRUG LABEL 17 0642-0093 CAPSULE, LIQUID FILLED 29 mg ORAL UNAPPROVED DRUG OTHER 13 sections
Vitafol Nano HUMAN PRESCRIPTION DRUG LABEL 7 0642-0094 TABLET, COATED 18 mg ORAL UNAPPROVED DRUG OTHER 14 sections
Select OB HUMAN PRESCRIPTION DRUG LABEL 15 0642-0120 TABLET, CHEWABLE 29 mg ORAL UNAPPROVED DRUG OTHER 13 sections
Strovite Forte Caplet HUMAN PRESCRIPTION DRUG LABEL 19 0642-0204 TABLET, COATED 10 mg ORAL UNAPPROVED DRUG OTHER 15 sections
Reaphirm Plant Source DHA HUMAN PRESCRIPTION DRUG LABEL 16 0642-3010 CAPSULE, GELATIN COATED 29 mg ORAL unapproved drug other 7 sections
Vitafol Fe Plus HUMAN PRESCRIPTION DRUG LABEL 17 0642-7473 CAPSULE, LIQUID FILLED 90 mg ORAL UNAPPROVED DRUG OTHER 14 sections
Polysaccharide-Iron HUMAN OTC DRUG LABEL 1 17714-077 CAPSULE 150 mg ORAL unapproved drug other 10 sections
Centratex HUMAN PRESCRIPTION DRUG LABEL 13 23359-100 CAPSULE 106 mg ORAL unapproved drug other 13 sections
NataChew HUMAN PRESCRIPTION DRUG LABEL 11 44118-902 TABLET, CHEWABLE 28 mg ORAL unapproved drug other 7 sections
Prenatal Vitamins Plus Low Iron HUMAN PRESCRIPTION DRUG LABEL 15 50090-0616 TABLET 27 mg ORAL Unapproved drug other 9 sections
Nestabs ONE HUMAN PRESCRIPTION DRUG LABEL 10 50967-410 CAPSULE, GELATIN COATED 38 mg ORAL unapproved drug other 12 sections
Nestabs ONE HUMAN PRESCRIPTION DRUG LABEL 10 50967-410 CAPSULE, GELATIN COATED 38 mg ORAL unapproved drug other 12 sections
Concept OB HUMAN PRESCRIPTION DRUG LABEL 15 52747-620 CAPSULE 92.40 mg ORAL unapproved drug other 13 sections
Concept DHA HUMAN PRESCRIPTION DRUG LABEL 15 52747-621 CAPSULE, LIQUID FILLED 38 mg ORAL unapproved drug other 7 sections
7 Heavy Metal Detox HUMAN OTC DRUG LABEL 61 55146-007 LIQUID 12 [hp_X] ORAL unapproved homeopathic 9 sections