All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

iron 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
	4277	7439-89-6

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: iron elemental iron (as carbonyl iron)	A metallic element with atomic symbol Fe, atomic number 26, and atomic weight 55.85. It is an essential constituent of HEMOGLOBINS; CYTOCHROMES; and IRON-BINDING PROTEINS. It plays a role in cellular redox reactions and in the transport of OXYGEN. Molecular weight: 55.85 Formula: Fe CLOGP: -1.32 LIPINSKI: None HAC: 0 HDO: 0 TPSA: ALOGS: ROTB: 0

Drug dosage:

None

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
None	FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Hand deformity	166.36	10	7	78219	159450	63251346
Glossodynia	155.09	10	19	78207	178857	63231939
Haemoglobin decreased	137.51	10	443	77783	145042	63265754
Blood iron decreased	128.74	10	122	78104	14599	63396197
Pericarditis	124.41	10	10	78216	131569	63279227
Systemic lupus erythematosus	104.58	10	64	78162	208854	63201942
Helicobacter infection	96.99	10	4	78222	92781	63318015
Anaemia	96.93	10	656	77570	292774	63118022
Contraindicated product administered	95.32	10	77	78149	217571	63193225
Premature labour	91.45	10	94	78132	12410	63398386
Colitis ulcerative	90.93	10	135	78091	25956	63384840
Drug intolerance	78.67	10	164	78062	308497	63102299
Heavy menstrual bleeding	78.42	10	103	78123	17670	63393126
Exposure during pregnancy	76.86	10	387	77839	155160	63255636
Synovitis	72.45	10	74	78152	186844	63223952
Haematochezia	70.79	10	184	78042	53360	63357436
Product dose omission issue	70.36	10	512	77714	233801	63176995
Discomfort	67.47	10	64	78162	167310	63243486
Premature delivery	65.93	10	127	78099	30154	63380642
Wound	65.14	10	63	78163	163200	63247596
Drug ineffective	62.93	10	909	77317	1043856	62366940
Frequent bowel movements	62.14	10	106	78120	22916	63387880
Weight decreased	60.57	10	563	77663	276235	63134561
Folliculitis	59.62	10	8	78218	70309	63340487
Toxicity to various agents	59.14	10	136	78090	247114	63163682
Drug abuse	55.35	10	11	78215	72507	63338289
Abdominal pain	54.55	10	577	77649	292879	63117917
Muscle injury	54.08	10	8	78218	65337	63345459
Swelling	51.31	10	171	78055	275207	63135589
Intentional overdose	47.52	10	16	78210	74136	63336660
Sleep disorder due to general medical condition, insomnia type	46.59	10	5	78221	52212	63358584
Hair follicle tumour benign	45.95	10	18	78208	413	63410383
Alopecia	45.25	10	238	77988	337298	63073498
Therapeutic product effect decreased	44.79	10	108	78118	193079	63217717
Irritable bowel syndrome	44.43	10	23	78203	82389	63328407
Treatment failure	44.02	10	114	78112	198929	63211867
Arthropathy	43.58	10	146	78080	234646	63176150
Blister	43.18	10	58	78168	129756	63281040
Mineral supplementation	42.45	10	20	78206	729	63410067
Transfusion	42.31	10	71	78155	15146	63395650
Vaginal haemorrhage	42.17	10	100	78126	27387	63383409
Hypersensitivity	41.71	10	202	78024	292483	63118313
Drug interaction	40.83	10	145	78081	228986	63181810
Allergy to metals	39.74	10	19	78207	716	63410080
Choreoathetosis	39.10	10	17	78209	512	63410284
Blood cholesterol increased	39.01	10	35	78191	93997	63316799
Therapeutic reaction time decreased	38.22	10	28	78198	2342	63408454
Ill-defined disorder	38.22	10	27	78199	81728	63329068
Clostridium difficile infection	37.68	10	101	78125	29821	63380975
Overdose	37.68	10	52	78174	115026	63295770
Liver injury	37.17	10	14	78212	60506	63350290
Off label use	36.88	10	1089	77137	673373	62737423
Hepatic enzyme increased	36.73	10	127	78099	202201	63208595
Abdominal discomfort	36.73	10	238	77988	320647	63090149
Inappropriate schedule of product administration	36.38	10	236	77990	103729	63307067
Device expulsion	36.31	10	110	78116	34812	63375984
Uterine leiomyoma	35.56	10	50	78176	9148	63401648
Defaecation urgency	35.36	10	34	78192	4141	63406655
Joint swelling	35.03	10	248	77978	327418	63083378
Full blood count abnormal	34.96	10	102	78124	31615	63379181
Poor venous access	34.65	10	64	78162	14721	63396075
Diarrhoea	33.57	10	1134	77092	714232	62696564
Chronic disease	33.17	10	11	78215	153	63410643
C-reactive protein abnormal	33.13	10	8	78218	46088	63364708
Neutropenia	32.34	10	109	78117	174896	63235900
Caesarean section	31.78	10	67	78159	16965	63393831
Crohn's disease	30.73	10	34	78192	4879	63405917
Gastrointestinal haemorrhage	30.71	10	188	78038	80988	63329808
Blood pressure fluctuation	30.11	10	125	78101	46192	63364604
Athetosis	29.68	10	8	78218	51	63410745
Device dislocation	29.62	10	84	78142	25621	63385175
Heart rate increased	29.43	10	208	78018	94030	63316766
Fluid retention	29.08	10	148	78078	59538	63351258
Complications of bone marrow transplant	28	10	13	78213	458	63410338
Confusional state	27.71	10	174	78052	236206	63174590
Faeces discoloured	26.95	10	66	78160	18443	63392353
Stomatitis	26.59	10	85	78141	138640	63272156
Iron deficiency	26.04	10	38	78188	7192	63403604
Mobility decreased	25.56	10	71	78155	121088	63289708
Hepatosplenic T-cell lymphoma	24.95	10	13	78213	590	63410206
Anal fissure	24.83	10	29	78197	4414	63406382
Normal newborn	24.64	10	40	78186	8301	63402495
Device placement issue	24.29	10	17	78209	1323	63409473
Illness	24.15	10	122	78104	48937	63361859
Blood albumin decreased	24.05	10	55	78171	14711	63396085
Myringotomy	24.01	10	6	78220	27	63410769
Cardiac arrest	23.67	10	49	78177	92496	63318300
General physical health deterioration	23.21	10	149	78077	201253	63209543
Febrile neutropenia	23.11	10	72	78154	118377	63292419
Nasal congestion	22.93	10	149	78077	65511	63345285
Fibromyalgia	22.83	10	40	78186	80380	63330416
Headache	22.53	10	974	77252	632267	62778529
Joint space narrowing	22.34	10	12	78214	580	63410216
Drug reaction with eosinophilia and systemic symptoms	22.21	10	7	78219	33829	63376967
Intestinal obstruction	22.17	10	86	78140	30813	63379983
Gastrointestinal tract mucosal pigmentation	22.15	10	12	78214	590	63410206
Complication of device insertion	21.97	10	36	78190	7528	63403268
Small intestine ulcer	21.68	10	10	78216	347	63410449
Iodine allergy	21.46	10	13	78213	791	63410005
Vitamin D decreased	21.13	10	42	78184	10200	63400596
Maternal exposure during breast feeding	20.95	10	26	78200	4215	63406581
Iron deficiency anaemia	20.85	10	63	78163	19906	63390890
Dysmenorrhoea	20.66	10	25	78201	3948	63406848
Infusion related reaction	20.66	10	198	78028	245323	63165473
Hip arthroplasty	20.65	10	17	78209	47629	63363167
Hyponatraemia	20.45	10	70	78156	111830	63298966
Acute kidney injury	19.87	10	218	78008	263197	63147599
Pregnancy	19.84	10	94	78132	36742	63374054
Rash	19.80	10	533	77693	560338	62850458
Stress	19.67	10	146	78080	67021	63343775
Flushing	19.11	10	158	78068	74929	63335867
Incorrect dose administered	19.09	10	133	78093	59835	63350961
Preterm premature rupture of membranes	19.08	10	15	78211	1394	63409402
Blood growth hormone increased	19.07	10	10	78216	460	63410336
Arthritis infective	19.05	10	31	78195	6447	63404349
Suicide attempt	18.49	10	29	78197	60889	63349907
Depressed level of consciousness	18.42	10	30	78196	62048	63348748
Eosinophilia	18.34	10	3	78223	22753	63388043
Granuloma skin	17.89	10	35	78191	8402	63402394
Chills	17.87	10	216	78010	113162	63297634
Empty sella syndrome	17.79	10	5	78221	38	63410758
Prescribed overdose	17.72	10	10	78216	34143	63376653
Gastric bypass	17.71	10	16	78210	1801	63408995
Psoriatic arthropathy	17.59	10	56	78170	91464	63319332
Splenomegaly	17.56	10	41	78185	11116	63399680
Red blood cell count decreased	17.22	10	97	78129	40548	63370248
Abnormal faeces	17.18	10	27	78199	5453	63405343
Hypervolaemia	17.16	10	75	78151	28338	63382458
Delayed haemolytic transfusion reaction	17.10	10	3	78223	0	63410796
Drug level decreased	16.97	10	33	78193	7886	63402910
Impaired healing	16.87	10	67	78159	102475	63308321
Drug level below therapeutic	16.70	10	25	78201	4841	63405955
Rheumatoid factor positive	16.68	10	51	78175	84355	63326441
Oropharyngeal pain	16.67	10	184	78042	94303	63316493
Fatigue	16.65	10	1289	76937	886739	62524057
Embedded device	16.64	10	21	78205	3462	63407334
Abdominal abscess	16.61	10	24	78202	4502	63406294
Intestinal resection	16.60	10	19	78207	2829	63407967
Blood parathyroid hormone decreased	16.53	10	37	78189	9754	63401042
Coma	16.52	10	34	78192	64330	63346466
Muscle spasms	16.40	10	277	77949	155873	63254923
Natural killer cell count	16.38	10	4	78222	16	63410780
Amegakaryocytic thrombocytopenia	16.38	10	4	78222	16	63410780
Antineutrophil cytoplasmic antibody positive	16.34	10	10	78216	620	63410176
Rhabdomyolysis	16.34	10	18	78208	43933	63366863
Vascular device infection	16.32	10	31	78195	7281	63403515
Mucous stools	16.28	10	23	78203	4225	63406571
Uterine perforation	16.14	10	30	78196	6933	63403863
Full blood count decreased	15.95	10	69	78157	25955	63384841
Haemoglobin abnormal	15.85	10	25	78201	5063	63405733
Intermenstrual bleeding	15.75	10	32	78194	7894	63402902
Rhinorrhoea	15.63	10	136	78090	65441	63345355
Vascular stenosis	15.58	10	8	78218	352	63410444
Malabsorption	15.54	10	22	78204	4050	63406746
Premature separation of placenta	15.47	10	15	78211	1846	63408950
Sinus pain	15.41	10	20	78206	3390	63407406
Myelosuppression	15.38	10	5	78221	23698	63387098
Macrophages increased	15.19	10	4	78222	23	63410773
Urinary tract infection	15.09	10	430	77796	264254	63146542
Chronic spontaneous urticaria	14.99	10	12	78214	1145	63409651
Faecal calprotectin increased	14.81	10	19	78207	3184	63407612
Haematocrit decreased	14.80	10	91	78135	39249	63371547
Small intestinal obstruction	14.79	10	53	78173	18284	63392512
Hospitalisation	14.70	10	165	78061	84916	63325880
Foreign body in reproductive tract	14.61	10	10	78216	751	63410045
Dyschezia	14.56	10	16	78210	2278	63408518
Multiple organ dysfunction syndrome	14.55	10	30	78196	56722	63354074
Injection site alopecia	14.52	10	4	78222	28	63410768
Small intestinal stenosis	14.50	10	9	78217	572	63410224
Polymenorrhoea	14.42	10	12	78214	1209	63409587
Completed suicide	14.23	10	113	78113	145560	63265236
Toxoplasmosis	14.04	10	13	78213	1510	63409286
Serotonin syndrome	14.03	10	9	78217	28673	63382123
Grip strength decreased	13.95	10	5	78221	22282	63388514
Intercepted medication error	13.94	10	9	78217	613	63410183
Appetite disorder	13.89	10	29	78197	7292	63403504
Pre-eclampsia	13.76	10	33	78193	9100	63401696
Haemorrhage	13.75	10	125	78101	60897	63349899
Acute lung injury	13.70	10	13	78213	1558	63409238
Leukopenia	13.69	10	49	78177	77241	63333555
Nephrogenic systemic fibrosis	13.66	10	22	78204	4534	63406262
Joint range of motion decreased	13.53	10	12	78214	32416	63378380
Eosinophilic pneumonia chronic	13.46	10	6	78220	192	63410604
Dizziness	13.44	10	653	77573	429272	62981524
Blood pressure increased	13.38	10	277	77949	161785	63249011
Vaginal infection	13.36	10	29	78197	7489	63403307
Uterine atony	13.29	10	6	78220	198	63410598
Platelet count increased	13.28	10	50	78176	17661	63393135
Sedation	13.24	10	17	78209	38792	63372004
Weight fluctuation	13.23	10	34	78192	9785	63401011
Skin warm	13.20	10	24	78202	5452	63405344
Gastrointestinal disorder	13.19	10	101	78125	131138	63279658
Maternal exposure before pregnancy	13.14	10	29	78197	7574	63403222
Mean cell haemoglobin concentration decreased	13.03	10	19	78207	3593	63407203
Fistula	13	10	35	78191	10358	63400438
Hepatic function abnormal	12.96	10	16	78210	37126	63373670
Asthenia	12.92	10	587	77639	383017	63027779
Body temperature fluctuation	12.91	10	15	78211	2270	63408526
Postpartum haemorrhage	12.90	10	14	78212	1967	63408829
Bone marrow reticulin fibrosis	12.83	10	6	78220	215	63410581
COVID-19	12.75	10	203	78023	112900	63297896
Palindromic rheumatism	12.73	10	6	78220	219	63410577
Rash pruritic	12.72	10	121	78105	59678	63351118
Septic shock	12.64	10	41	78185	66588	63344208
Cytomegalovirus infection	12.61	10	5	78221	20947	63389849
Respiratory arrest	12.54	10	13	78213	32632	63378164
Hyperparathyroidism secondary	12.52	10	12	78214	1455	63409341
Molluscum contagiosum	12.50	10	6	78220	228	63410568
Stress at work	12.50	10	11	78215	1196	63409600
Anal incontinence	12.49	10	41	78185	13535	63397261
Dermatitis atopic	12.42	10	33	78193	9691	63401105
Bronchospasm	12.41	10	3	78223	17277	63393519
Rectal haemorrhage	12.38	10	103	78123	48927	63361869
Uterine contractions during pregnancy	12.30	10	8	78218	552	63410244
Acute myeloid leukaemia	12.27	10	3	78223	17144	63393652
Flatulence	12.27	10	79	78147	34623	63376173
Glomerulonephritis rapidly progressive	12.22	10	10	78216	985	63409811
Hot flush	12.14	10	106	78120	51053	63359743
Rash macular	12.13	10	59	78167	23305	63387491
Insomnia	12.07	10	349	77877	214903	63195893
Sinus disorder	12.04	10	61	78165	24492	63386304
Pneumocystis jirovecii pneumonia	12.03	10	3	78223	16911	63393885
Drug specific antibody present	12.01	10	20	78206	4239	63406557
Shock	11.99	10	7	78219	23456	63387340
Panniculitis	11.96	10	36	78190	11349	63399447
Agitation	11.88	10	36	78190	59721	63351075
Complication of device removal	11.72	10	22	78204	5120	63405676
Oedema peripheral	11.67	10	311	77915	189200	63221596
Cough	11.67	10	456	77770	292287	63118509
Device breakage	11.66	10	36	78190	11506	63399290
Wound infection bacterial	11.63	10	8	78218	606	63410190
Condition aggravated	11.56	10	606	77620	401611	63009185
Haemorrhoids	11.55	10	56	78170	22094	63388702
Sulphaemoglobinaemia	11.43	10	3	78223	17	63410779
Uterine haemorrhage	11.43	10	19	78207	4022	63406774
Creatinine renal clearance decreased	11.39	10	3	78223	16305	63394491
Pulmonary cavitation	11.37	10	9	78217	845	63409951
Crystal urine present	11.31	10	12	78214	1642	63409154
Myelofibrosis	11.26	10	11	78215	1366	63409430
Antineutrophil cytoplasmic antibody increased	11.25	10	5	78221	159	63410637
Renal transplant	11.24	10	11	78215	1369	63409427
Gastrointestinal bacterial overgrowth	11.11	10	9	78217	873	63409923
Delivery	11.09	10	11	78215	1392	63409404
Thyroid adenoma	11.05	10	5	78221	166	63410630
Pulmonary arterial hypertension	11.01	10	56	78170	22521	63388275
Cholestasis	11.00	10	12	78214	29422	63381374
Overlap syndrome	10.99	10	9	78217	887	63409909
Type 2 diabetes mellitus	10.97	10	41	78185	63827	63346969
Premature rupture of membranes	10.94	10	21	78205	4972	63405824
Bursitis	10.90	10	18	78208	37023	63373773
Breath sounds abnormal	10.88	10	34	78192	10939	63399857
Diarrhoea haemorrhagic	10.86	10	30	78196	9012	63401784
Hypokalaemia	10.85	10	79	78147	103725	63307071
Otorrhoea	10.85	10	11	78215	1428	63409368
Twin pregnancy	10.79	10	10	78216	1163	63409633
Blood creatine phosphokinase increased	10.73	10	13	78213	30417	63380379
Cardio-respiratory arrest	10.62	10	38	78188	59921	63350875
Ileostomy	10.58	10	11	78215	1471	63409325
Lower respiratory tract infection	10.57	10	108	78118	132199	63278597
Purulent discharge	10.56	10	20	78206	4686	63406110
Sterile pyuria	10.54	10	3	78223	24	63410772
Knee arthroplasty	10.53	10	33	78193	54173	63356623
Drug hypersensitivity	10.48	10	297	77929	310390	63100406
Gastrointestinal candidiasis	10.44	10	5	78221	189	63410607
Hepatocellular injury	10.41	10	11	78215	27370	63383426
Sprue-like enteropathy	10.26	10	8	78218	735	63410061
Anaemia of pregnancy	10.24	10	4	78222	91	63410705
Liver disorder	10.21	10	33	78193	53654	63357142
Cataplexy	10.21	10	10	78216	1246	63409550
Drug resistance	10.16	10	8	78218	22925	63387871
Amniotic cavity infection	10.16	10	10	78216	1253	63409543
Viral infection	10.14	10	77	78149	35586	63375210
Peritonitis bacterial	10.05	10	20	78206	4859	63405937
Hypercholesterolaemia	10.03	10	7	78219	21327	63389469

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Colitis ulcerative	158.46	11.77	125	30698	16395	34909713
Blood iron decreased	100.30	11.77	61	30762	5252	34920856
Fatigue	86.48	11.77	590	30233	370063	34556045
Haematochezia	77.99	11.77	144	30679	46390	34879718
Diarrhoea	72.89	11.77	589	30234	389323	34536785
Nipple swelling	69.35	11.77	21	30802	306	34925802
Drug abuse	62.81	11.77	7	30816	99089	34827019
Frequent bowel movements	51.62	11.77	60	30763	12727	34913381
Nipple pain	51.04	11.77	22	30801	915	34925193
Haemoglobin decreased	47.80	11.77	222	30601	120550	34805558
Abdominal pain	46.30	11.77	274	30549	163344	34762764
Weight decreased	42.27	11.77	283	30540	176018	34750090
Febrile neutropenia	41.24	11.77	36	30787	136813	34789295
Inappropriate schedule of product administration	40.53	11.77	134	30689	62162	34863946
Device interaction	39.55	11.77	16	30807	566	34925542
Full blood count decreased	38.16	11.77	62	30761	18026	34908082
Toxicity to various agents	35.88	11.77	77	30746	200285	34725823
Asthenia	35.56	11.77	351	30472	244900	34681208
Faecal calprotectin increased	35.14	11.77	24	30799	2520	34923588
Large intestine polyp	33.40	11.77	38	30785	7876	34918232
Off label use	33.15	11.77	536	30287	418988	34507120
Exposure during pregnancy	32.89	11.77	40	30783	8894	34917214
Clostridium difficile infection	32.29	11.77	59	30764	18839	34907269
Crohn's disease	30.77	11.77	24	30799	3093	34923015
Faeces discoloured	30.04	11.77	50	30773	14828	34911280
Mucous stools	29.97	11.77	19	30804	1759	34924349
Polyneuropathy in malignant disease	28.57	11.77	10	30813	235	34925873
Interstitial lung disease	28.39	11.77	11	30812	65271	34860837
Gastrointestinal tract mucosal pigmentation	28.32	11.77	12	30811	478	34925630
Nephrogenic systemic fibrosis	27.47	11.77	25	30798	3980	34922128
Weight increased	27.04	11.77	157	30666	92876	34833232
Blood pressure fluctuation	26.94	11.77	65	30758	25184	34900924
Gastrointestinal haemorrhage	26.82	11.77	151	30672	88326	34837782
Polyp	26.12	11.77	24	30799	3868	34922240
Maternal exposure before pregnancy	25.73	11.77	13	30810	778	34925330
Drug interaction	25.23	11.77	108	30715	225838	34700270
Acute kidney injury	25.00	11.77	162	30661	304826	34621282
Constipation	24.88	11.77	206	30617	136776	34789332
Anaemia	24.68	11.77	314	30509	233021	34693087
Mineral supplementation	23.71	11.77	7	30816	93	34926015
Product dose omission issue	23.35	11.77	183	30640	119528	34806580
Condition aggravated	22.20	11.77	263	30560	191933	34734175
Flatulence	20.95	11.77	53	30770	21145	34904963
Muscle spasms	20.14	11.77	124	30699	74877	34851231
Intentional product use issue	20.08	11.77	105	30718	59711	34866397
Iron deficiency anaemia	19.90	11.77	34	30789	10295	34915813
Blood pressure increased	19.62	11.77	139	30684	87963	34838145
Intentional overdose	19.59	11.77	7	30816	43667	34882441
Rhabdomyolysis	19.25	11.77	19	30804	68144	34857964
Normochromic normocytic anaemia	18.80	11.77	21	30802	4266	34921842
Gastrointestinal inflammation	18.57	11.77	19	30804	3492	34922616
Intestinal resection	18.43	11.77	14	30809	1735	34924373
Completed suicide	18.15	11.77	37	30786	98131	34827977
Suicide attempt	18.01	11.77	6	30817	39110	34886998
Hospitalisation	17.82	11.77	98	30725	56804	34869304
Arthralgia	17.60	11.77	228	30595	169813	34756295
Vanishing bile duct syndrome	17.46	11.77	11	30812	1007	34925101
Abdominal discomfort	17.39	11.77	101	30722	59734	34866374
Agitated depression	17.29	11.77	7	30816	248	34925860
Thrombocytopenia	17.23	11.77	75	30748	156172	34769936
Aplasia pure red cell	17.18	11.77	24	30799	6108	34920000
Poor venous access	17.15	11.77	22	30801	5161	34920947
Haemorrhage	17.12	11.77	90	30733	51280	34874828
Heart rate decreased	16.94	11.77	64	30759	31681	34894427
Aspartate aminotransferase increased	16.83	11.77	21	30802	67762	34858346
Malaise	16.72	11.77	243	30580	185582	34740526
Thrombosis	16.54	11.77	88	30735	50370	34875738
Anal ulcer	16.28	11.77	10	30813	876	34925232
Gastroduodenal haemorrhage	15.92	11.77	6	30817	175	34925933
Intestinal obstruction	15.65	11.77	50	30773	22772	34903336
Therapeutic reaction time decreased	15.31	11.77	11	30812	1252	34924856
Low birth weight baby	15.20	11.77	26	30797	7879	34918229
Diet noncompliance	15.17	11.77	6	30817	200	34925908
Therapeutic response shortened	15.10	11.77	25	30798	7379	34918729
Premature baby	14.37	11.77	44	30779	19589	34906519
Faecal calprotectin abnormal	14.23	11.77	6	30817	236	34925872
Nasopharyngitis	14.20	11.77	108	30715	69860	34856248
Drug-induced liver injury	14.03	11.77	4	30819	28828	34897280
Abdominal distension	14.03	11.77	94	30729	58398	34867710
Agitation	14.02	11.77	18	30805	57381	34868727
Skin induration	13.92	11.77	13	30810	2138	34923970
Autoscopy	13.89	11.77	6	30817	251	34925857
Supraventricular tachycardia	13.37	11.77	30	30793	11087	34915021
Heart rate increased	13.31	11.77	78	30745	46265	34879843
Aphthous ulcer	13.18	11.77	19	30804	4976	34921132
Hip fracture	13.04	11.77	31	30792	11894	34914214
Spondylitis	12.96	11.77	10	30813	1268	34924840
Hernia	12.82	11.77	27	30796	9556	34916552
Drug level decreased	12.78	11.77	24	30799	7822	34918286
Anaemia neonatal	12.68	11.77	6	30817	311	34925797
Intestinal mucosal hypertrophy	12.53	11.77	4	30819	70	34926038
Product use issue	12.51	11.77	97	30726	63119	34862989
Fistula	12.51	11.77	22	30801	6818	34919290
Anal fissure	12.33	11.77	17	30806	4273	34921835
Inflammatory bowel disease	12.28	11.77	14	30809	2906	34923202
Meconium abnormal	12.13	11.77	4	30819	78	34926030
Gait inability	12.04	11.77	43	30780	20715	34905393
Cerebral haemorrhage	12.03	11.77	8	30815	34929	34891179
Maternal exposure during pregnancy	11.96	11.77	18	30805	4900	34921208
Intestinal stenosis	11.87	11.77	12	30811	2174	34923934
Gastroenteritis viral	11.86	11.77	22	30801	7102	34919006
Allodynia	11.86	11.77	8	30815	823	34925285
Faeces soft	11.78	11.77	15	30808	3493	34922615

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Colitis ulcerative	210.79	10.14	222	85713	34520	79623933
Blood iron decreased	183.55	10.14	144	85791	15290	79643163
Haematochezia	127.76	10.14	288	85647	87357	79571096
Haemoglobin decreased	126.40	10.14	524	85411	221595	79436858
Drug abuse	123.59	10.14	15	85920	162676	79495777
Frequent bowel movements	106.76	10.14	145	85790	29394	79629059
Abdominal pain	101.59	10.14	743	85192	388826	79269627
Off label use	98.13	10.14	1444	84491	905771	78752682
Toxicity to various agents	91.40	10.14	199	85736	421341	79237112
Inappropriate schedule of product administration	90.37	10.14	333	85602	133295	79525158
Premature delivery	89.10	10.14	118	85817	23349	79635104
Hand deformity	82.94	10.14	8	85927	103911	79554542
Weight decreased	80.61	10.14	656	85279	354542	79303911
Exposure during pregnancy	80.48	10.14	266	85669	100866	79557587
Fatigue	80.30	10.14	1426	84509	928301	78730152
Heavy menstrual bleeding	75.29	10.14	84	85851	13927	79644526
Pericarditis	73.55	10.14	12	85923	104224	79554229
Anaemia	69.50	10.14	759	85176	444256	79214197
Drug interaction	68.73	10.14	224	85711	414959	79243494
Clostridium difficile infection	67.53	10.14	145	85790	42540	79615913
Product dose omission issue	66.66	10.14	476	85459	247061	79411392
Nipple swelling	65.58	10.14	21	85914	300	79658153
Neutropenia	61.33	10.14	137	85798	287573	79370880
Febrile neutropenia	60.65	10.14	97	85838	230902	79427551
Acute kidney injury	59.47	10.14	323	85612	519081	79139372
Diarrhoea	59.23	10.14	1301	84634	879188	78779265
Duodenal ulcer perforation	58.87	10.14	3	85932	66208	79592245
Mineral supplementation	58.87	10.14	25	85910	815	79657638
Intentional overdose	57.68	10.14	21	85914	105939	79552514
Blood pressure fluctuation	55.56	10.14	179	85756	66966	79591487
Glossodynia	55.37	10.14	21	85914	103316	79555137
Poor venous access	55.11	10.14	82	85853	18067	79640386
Condition aggravated	54.82	10.14	800	85135	500324	79158129
Faecal calprotectin increased	53.90	10.14	46	85889	5495	79652958
Therapeutic reaction time decreased	53.55	10.14	38	85897	3463	79654990
Faeces discoloured	52.01	10.14	104	85831	29023	79629430
Device expulsion	50.63	10.14	96	85839	25765	79632688
Gastrointestinal tract mucosal pigmentation	50.44	10.14	24	85911	1026	79657427
Overdose	49.63	10.14	76	85859	184130	79474323
Helicobacter infection	49.23	10.14	8	85927	69696	79588757
Contraindicated product administered	47.43	10.14	60	85875	157478	79500975
Nipple pain	47.05	10.14	22	85913	904	79657549
Synovitis	46.87	10.14	56	85879	150678	79507775
Hair follicle tumour benign	46.78	10.14	18	85917	452	79658001
Mucous stools	46.47	10.14	41	85894	5121	79653332
Premature labour	46.28	10.14	51	85884	8339	79650114
Intentional product use issue	45.35	10.14	300	85635	151812	79506641
Gastrointestinal haemorrhage	43.83	10.14	291	85644	147428	79511025
Hepatic function abnormal	42.39	10.14	13	85922	73094	79585359
Defaecation urgency	42.23	10.14	41	85894	5783	79652670
Anal fissure	39.37	10.14	45	85890	7658	79650795
Drug intolerance	38.01	10.14	151	85784	263968	79394485
Rhabdomyolysis	36.90	10.14	34	85901	103097	79555356
Heart rate increased	36.52	10.14	239	85696	120485	79537968
Device dislocation	36.33	10.14	84	85851	25886	79632567
Caesarean section	35.74	10.14	55	85880	12480	79645973
Folliculitis	35.62	10.14	8	85927	55372	79603081
Muscle injury	35.60	10.14	5	85930	48556	79609897
Transfusion	35.52	10.14	74	85861	21256	79637197
Weight increased	35.22	10.14	455	85480	276931	79381522
Chronic disease	34.82	10.14	11	85924	150	79658303
Vaginal haemorrhage	34.38	10.14	74	85861	21743	79636710
Fluid retention	33.78	10.14	157	85778	69652	79588801
Systemic lupus erythematosus	32.60	10.14	50	85885	121099	79537354
Suicide attempt	32.55	10.14	25	85910	82907	79575546
Interstitial lung disease	31.74	10.14	45	85890	112555	79545898
Agitation	31.04	10.14	37	85898	99678	79558775
Sleep disorder due to general medical condition, insomnia type	30.75	10.14	5	85930	43551	79614902
Iron deficiency anaemia	30.53	10.14	78	85857	25594	79632859
Uterine leiomyoma	30.20	10.14	36	85899	6407	79652046
Nasal congestion	29.86	10.14	162	85773	76390	79582063
Nephrogenic systemic fibrosis	29.83	10.14	35	85900	6125	79652328
Incorrect dose administered	29.78	10.14	162	85773	76468	79581985
Intestinal obstruction	29.72	10.14	108	85827	42912	79615541
Completed suicide	29.65	10.14	150	85785	245617	79412836
Leukopenia	29.55	10.14	50	85885	116463	79541990
Flatulence	29.30	10.14	107	85828	42617	79615836
Complication of device insertion	28.97	10.14	35	85900	6315	79652138
Drug level decreased	28.86	10.14	54	85881	14348	79644105
Choreoathetosis	28.65	10.14	19	85916	1551	79656902
Large intestine polyp	28.45	10.14	50	85885	12658	79645795
Intestinal resection	28.28	10.14	27	85908	3730	79654723
Eosinophilia	28.27	10.14	7	85928	45338	79613115
Drug level below therapeutic	28.04	10.14	43	85892	9727	79648726
Athetosis	27.64	10.14	9	85926	136	79658317
Full blood count decreased	27.37	10.14	77	85858	26742	79631711
C-reactive protein abnormal	27.33	10.14	9	85926	48358	79610095
Hyponatraemia	27.31	10.14	99	85836	177749	79480704
Abnormal faeces	27.10	10.14	37	85898	7534	79650919
Cardiac arrest	26.95	10.14	95	85840	172001	79486452
Flushing	26.85	10.14	175	85760	88093	79570360
Hospitalisation	26.36	10.14	183	85752	94053	79564400
Blood pressure increased	26.10	10.14	345	85590	211015	79447438
Complications of bone marrow transplant	25.75	10.14	13	85922	633	79657820
Coma	25.70	10.14	43	85892	100606	79557847
Device placement issue	25.46	10.14	16	85919	1191	79657262
Myringotomy	25.37	10.14	6	85929	24	79658429
Polyneuropathy in malignant disease	25.04	10.14	10	85925	278	79658175
Neurotoxicity	24.68	10.14	3	85932	32515	79625938
Headache	24.64	10.14	898	85037	652874	79005579
Normal newborn	24.47	10.14	34	85901	7038	79651415
Illness	24.29	10.14	107	85828	46404	79612049
Multiple organ dysfunction syndrome	24.19	10.14	59	85876	120187	79538266
Full blood count abnormal	24.16	10.14	97	85838	40377	79618076
Asthenia	23.92	10.14	721	85214	510968	79147485
Maternal exposure during pregnancy	23.64	10.14	238	85697	136300	79522153
Discomfort	23.46	10.14	64	85871	125553	79532900
Cerebral infarction	23.29	10.14	10	85925	45666	79612787
Rhinorrhoea	23.24	10.14	151	85784	75923	79582530
Urinary tract infection	23.12	10.14	420	85515	274092	79384361
Oropharyngeal pain	22.11	10.14	197	85738	109156	79549297
Drug reaction with eosinophilia and systemic symptoms	22.02	10.14	22	85913	64222	79594231
Hepatosplenic T-cell lymphoma	22.01	10.14	13	85922	865	79657588
Irritable bowel syndrome	21.70	10.14	21	85914	62220	79596233
Cytokine release syndrome	21.60	10.14	6	85929	35992	79622461
Maternal exposure before pregnancy	21.43	10.14	25	85910	4348	79654105
Iron deficiency	21.41	10.14	40	85895	10614	79647839
Uterine perforation	21.36	10.14	30	85905	6273	79652180
Device interaction	21.18	10.14	12	85923	738	79657715
Blood creatine phosphokinase increased	21.13	10.14	24	85911	66066	79592387
Wound	21.09	10.14	60	85875	116119	79542334
Confusional state	21.05	10.14	230	85705	317767	79340686
Therapeutic response shortened	20.76	10.14	50	85885	15813	79642640
Neutrophil count decreased	20.60	10.14	44	85891	93915	79564538
Myelosuppression	20.27	10.14	9	85926	40287	79618166
Malaise	20.20	10.14	680	85255	489189	79169264
Haemoglobin abnormal	20.18	10.14	31	85904	7023	79651430
Sedation	19.91	10.14	16	85919	51879	79606574
Preterm premature rupture of membranes	19.89	10.14	14	85921	1259	79657194
Muscle spasms	19.84	10.14	281	85654	174449	79484004
Depressed level of consciousness	19.78	10.14	47	85888	96605	79561848
Treatment failure	19.46	10.14	106	85829	170380	79488073
Hepatic cytolysis	19.43	10.14	3	85932	27148	79631305
Joint space narrowing	19.41	10.14	11	85924	677	79657776
Blood cholesterol increased	19.38	10.14	38	85897	83682	79574771
Blister	19.35	10.14	65	85870	119411	79539042
Heart rate decreased	19.34	10.14	136	85799	70180	79588273
Granuloma skin	19.14	10.14	35	85900	9139	79649314
Maternal exposure during breast feeding	19.07	10.14	19	85916	2766	79655687
Ischaemic stroke	19.01	10.14	6	85929	33125	79625328
Pancytopenia	18.95	10.14	103	85832	165642	79492811
Rectal haemorrhage	18.94	10.14	144	85791	76156	79582297
Allergy to metals	18.94	10.14	10	85925	535	79657918
Sopor	18.90	10.14	6	85929	33004	79625449
Cholestasis	18.85	10.14	17	85918	52092	79606361
Thrombocytopenia	18.71	10.14	189	85746	265070	79393383
Drug specific antibody present	18.70	10.14	29	85906	6623	79651830
Gastrointestinal inflammation	18.63	10.14	31	85904	7513	79650940
Coronary artery disease	18.61	10.14	26	85909	65448	79593005
Hip fracture	18.59	10.14	74	85861	30687	79627766
Pyrexia	18.45	10.14	574	85361	678135	78980318
Blood parathyroid hormone decreased	18.07	10.14	37	85898	10499	79647954
Embedded device	18.00	10.14	20	85915	3299	79655154
Polymenorrhoea	17.98	10.14	12	85923	990	79657463
Dyschezia	17.95	10.14	19	85916	2969	79655484
Cytomegalovirus infection	17.85	10.14	12	85923	42632	79615821
Sinus pain	17.69	10.14	21	85914	3721	79654732
Serum ferritin	17.50	10.14	3	85932	0	79658453
Arthralgia	17.47	10.14	768	85167	571035	79087418
Small intestinal stenosis	17.44	10.14	11	85924	824	79657629
Haemorrhage	17.33	10.14	162	85773	90956	79567497
Arthropod bite	17.27	10.14	32	85903	8439	79650014
Agranulocytosis	17.13	10.14	14	85921	45016	79613437
Postpartum haemorrhage	17.08	10.14	14	85921	1581	79656872
Vaginal infection	17.05	10.14	26	85909	5854	79652599
Complication of device removal	17.04	10.14	21	85914	3868	79654585
Intermenstrual bleeding	17.03	10.14	26	85909	5858	79652595
Acute myeloid leukaemia	17.01	10.14	6	85929	30879	79627574
Malignant neoplasm progression	16.96	10.14	82	85853	135908	79522545
Bowel movement irregularity	16.96	10.14	27	85908	6307	79652146
Natural killer cell count	16.92	10.14	4	85931	16	79658437
Dyspnoea	16.77	10.14	1104	84831	855921	78802532
Hypokalaemia	16.74	10.14	89	85846	143951	79514502
Amegakaryocytic thrombocytopenia	16.72	10.14	4	85931	17	79658436
Product use issue	16.61	10.14	318	85617	209504	79448949
Dizziness	16.50	10.14	709	85226	525732	79132721
Heart valve replacement	16.42	10.14	11	85924	913	79657540
Cerebral haemorrhage	16.30	10.14	23	85912	57650	79600803
Premature rupture of membranes	16.28	10.14	21	85914	4048	79654405
Electrocardiogram QT prolonged	16.17	10.14	47	85888	90339	79568114
Pre-eclampsia	16.15	10.14	28	85907	7013	79651440
Delivery	16.06	10.14	10	85925	732	79657721
Blood albumin decreased	16.02	10.14	60	85875	24183	79634270
Therapeutic product effect decreased	16.01	10.14	107	85828	163756	79494697
Dysmenorrhoea	15.92	10.14	18	85917	3027	79655426
Bone marrow failure	15.86	10.14	19	85916	51088	79607365
Chronic spontaneous urticaria	15.82	10.14	12	85923	1212	79657241
Polyp	15.75	10.14	30	85905	8077	79650376
Premature separation of placenta	15.63	10.14	12	85923	1234	79657219
Liver injury	15.58	10.14	23	85912	56591	79601862
Hepatic enzyme increased	15.55	10.14	124	85811	182486	79475967
Constipation	15.47	10.14	407	85528	282643	79375810
Neutropenic sepsis	15.35	10.14	5	85930	27059	79631394
Arthritis infective	15.33	10.14	30	85905	8241	79650212
Drug-induced liver injury	15.31	10.14	30	85905	66087	79592366
Stomatitis	15.27	10.14	94	85841	146663	79511790
Gamma-glutamyltransferase increased	15.26	10.14	22	85913	54658	79603795
Rash maculo-papular	15.22	10.14	23	85912	56055	79602398
Epilepsy	15.18	10.14	13	85922	40847	79617606
Extrapyramidal disorder	15.15	10.14	3	85932	22676	79635777
Splenomegaly	15.10	10.14	53	85882	20701	79637752
Fistula	15.06	10.14	39	85896	12901	79645552
Cardio-respiratory arrest	14.99	10.14	63	85872	108447	79550006
Toxic skin eruption	14.79	10.14	3	85932	22290	79636163
Uterine atony	14.66	10.14	6	85929	178	79658275
Pneumonitis	14.63	10.14	27	85908	60833	79597620
Dyskinesia	14.59	10.14	16	85919	44757	79613696
Peritonitis bacterial	14.56	10.14	32	85903	9535	79648918
Foreign body in reproductive tract	14.42	10.14	9	85926	662	79657791
Hyperparathyroidism secondary	14.38	10.14	16	85919	2644	79655809
Device breakage	14.35	10.14	34	85901	10641	79647812
Tumour lysis syndrome	14.34	10.14	4	85931	23935	79634518
Ill-defined disorder	14.31	10.14	31	85904	65844	79592609
Transferrin saturation decreased	14.29	10.14	11	85924	1135	79657318
Transaminases increased	14.26	10.14	21	85914	51722	79606731
Appetite disorder	14.26	10.14	28	85907	7711	79650742
Stress at work	14.25	10.14	11	85924	1140	79657313
Malabsorption	14.23	10.14	22	85913	5010	79653443
Body temperature fluctuation	14.23	10.14	19	85916	3788	79654665
Vessel puncture site pain	14.21	10.14	3	85932	6	79658447
Accidental overdose	14.21	10.14	13	85922	39568	79618885
Pregnancy	14.19	10.14	62	85873	26789	79631664
Neuroleptic malignant syndrome	14.11	10.14	6	85929	27553	79630900
Internal haemorrhage	13.96	10.14	30	85905	8803	79649650
Appendicectomy	13.95	10.14	16	85919	2732	79655721
Retching	13.93	10.14	46	85889	17421	79641032
Mobility decreased	13.92	10.14	76	85859	122099	79536354
Delayed haemolytic transfusion reaction	13.90	10.14	3	85932	7	79658446
Pulmonary arterial hypertension	13.87	10.14	64	85871	28302	79630151
Small intestine ulcer	13.85	10.14	9	85926	710	79657743
Mucosal inflammation	13.74	10.14	39	85896	75541	79582912
Abscess	13.69	10.14	55	85880	22896	79635557
Ventricular tachycardia	13.65	10.14	15	85920	41920	79616533
Respiratory failure	13.55	10.14	127	85808	180784	79477669
Diarrhoea haemorrhagic	13.51	10.14	38	85897	13196	79645257
Fibromyalgia	13.39	10.14	31	85904	64309	79594144
Cough	13.33	10.14	502	85433	366287	79292166
Hypervolaemia	13.20	10.14	85	85850	42605	79615848
Myopathy	13.16	10.14	3	85932	20560	79637893
Hepatitis	13.15	10.14	25	85910	55702	79602751
Skin induration	13.11	10.14	20	85915	4505	79653948
Gastric bypass	13.06	10.14	11	85924	1290	79657163
Vascular device infection	13.03	10.14	32	85903	10244	79648209
Posterior reversible encephalopathy syndrome	13.01	10.14	6	85929	26275	79632178
Dysarthria	12.96	10.14	34	85901	67588	79590865
Kidney infection	12.75	10.14	52	85883	21799	79636654
Drug ineffective	12.73	10.14	998	84937	1079915	78578538
Nasopharyngitis	12.72	10.14	361	85574	253520	79404933
Vascular stenosis	12.70	10.14	8	85927	598	79657855
Transferrin saturation increased	12.69	10.14	5	85930	134	79658319
Heart rate irregular	12.63	10.14	69	85866	32610	79625843
Respiratory arrest	12.57	10.14	27	85908	57523	79600930
Rectal tenesmus	12.54	10.14	12	85923	1663	79656790
Anal ulcer	12.51	10.14	11	85924	1367	79657086
Disorientation	12.47	10.14	31	85904	62745	79595708
Agitated depression	12.45	10.14	7	85928	424	79658029
Haemophagocytic lymphohistiocytosis	12.45	10.14	4	85931	21833	79636620
Aspartate aminotransferase increased	12.34	10.14	93	85842	138548	79519905
Chronic kidney disease	12.27	10.14	117	85818	66037	79592416
Sinus tachycardia	12.24	10.14	13	85922	36895	79621558
COVID-19 pneumonia	12.23	10.14	8	85927	28841	79629612
Skin warm	12.22	10.14	24	85911	6608	79651845
Panniculitis	12.12	10.14	35	85900	12336	79646117
Medication error	12.05	10.14	36	85899	68606	79589847
Left ventricular dysfunction	12.05	10.14	3	85932	19358	79639095
Vitamin D decreased	12.03	10.14	30	85905	9695	79648758
Gastroduodenal haemorrhage	11.96	10.14	6	85929	288	79658165
Arthritis	11.95	10.14	182	85753	114698	79543755
Swelling	11.95	10.14	163	85772	216548	79441905
Uterine infection	11.95	10.14	6	85929	289	79658164
Pancreatitis acute	11.93	10.14	22	85913	49582	79608871
Red blood cell count decreased	11.82	10.14	104	85831	57409	79601044
Breath sounds abnormal	11.78	10.14	41	85894	15943	79642510
Intercepted medication error	11.77	10.14	9	85926	920	79657533
Injection site pain	11.75	10.14	201	85734	129637	79528816
Serotonin syndrome	11.71	10.14	19	85916	45008	79613445
Gastrointestinal bacterial overgrowth	11.67	10.14	8	85927	690	79657763
Haematocrit decreased	11.65	10.14	109	85826	61203	79597250
Lactic acidosis	11.58	10.14	38	85897	70321	79588132
Bradycardia	11.56	10.14	92	85843	135465	79522988
Disseminated intravascular coagulation	11.47	10.14	13	85922	35829	79622624
Intestinal stenosis	11.45	10.14	17	85918	3737	79654716
Weight fluctuation	11.41	10.14	33	85902	11642	79646811
Calciphylaxis	11.40	10.14	17	85918	3753	79654700
Arthropathy	11.35	10.14	129	85806	176982	79481471
Cognitive disorder	11.35	10.14	38	85897	69888	79588565
Platelet count increased	11.28	10.14	51	85884	22355	79636098
Blood growth hormone increased	11.28	10.14	8	85927	728	79657725
Respiratory depression	11.26	10.14	8	85927	27622	79630831
Bronchiectasis	11.26	10.14	5	85930	22381	79636072
Hypersensitivity	11.19	10.14	207	85728	262032	79396421
Influenza	11.14	10.14	199	85736	129407	79529046
Viral infection	11.13	10.14	82	85853	42934	79615519
Septic shock	11.10	10.14	82	85853	122719	79535734
Abdominal abscess	11.03	10.14	24	85911	7103	79651350
Antineutrophil cytoplasmic antibody positive	11.02	10.14	10	85925	1296	79657157
Overlap syndrome	10.99	10.14	9	85926	1015	79657438
Alanine aminotransferase increased	10.98	10.14	117	85818	162453	79496000
Empty sella syndrome	10.76	10.14	4	85931	91	79658362
Pain in extremity	10.75	10.14	488	85447	364050	79294403
Chills	10.75	10.14	237	85698	159997	79498456
Sinus bradycardia	10.71	10.14	7	85928	25240	79633213
Basal cell carcinoma	10.70	10.14	73	85862	37302	79621151
Hepatocellular injury	10.67	10.14	22	85913	47571	79610882
Hot flush	10.65	10.14	98	85837	54779	79603674
Abnormal uterine bleeding	10.63	10.14	9	85926	1064	79657389
Cardiogenic shock	10.61	10.14	18	85917	41896	79616557
Infusion site swelling	10.60	10.14	25	85910	7801	79650652
Laryngeal stenosis	10.52	10.14	9	85926	1079	79657374
Insomnia	10.51	10.14	342	85593	244828	79413625
Subdural haematoma	10.51	10.14	11	85924	31423	79627030
Mydriasis	10.48	10.14	3	85932	17640	79640813
Acute myocardial infarction	10.47	10.14	45	85890	76991	79581462
Pelvic pain	10.46	10.14	35	85900	13346	79645107
Amniotic cavity infection	10.45	10.14	8	85927	819	79657634
Ileostomy	10.44	10.14	11	85924	1709	79656744
Intentional product misuse	10.40	10.14	60	85875	95105	79563348
Hypercholesterolaemia	10.35	10.14	6	85929	23089	79635364
Pregnancy on oral contraceptive	10.30	10.14	8	85927	837	79657616
Infusion site extravasation	10.29	10.14	29	85906	10079	79648374
Mean cell haemoglobin concentration decreased	10.23	10.14	18	85917	4561	79653892
Drug tolerance decreased	10.19	10.14	34	85901	12944	79645509
Myelofibrosis	10.16	10.14	13	85922	2487	79655966
Small intestinal obstruction	10.15	10.14	57	85878	27215	79631238
Vanishing bile duct syndrome	10.14	10.14	11	85924	1767	79656686

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	A11AA01	ALIMENTARY TRACT AND METABOLISM VITAMINS MULTIVITAMINS, COMBINATIONS Multivitamins with minerals
ATC	B03AE01	BLOOD AND BLOOD FORMING ORGANS ANTIANEMIC PREPARATIONS IRON PREPARATIONS Iron in other combinations
ATC	B03AE02	BLOOD AND BLOOD FORMING ORGANS ANTIANEMIC PREPARATIONS IRON PREPARATIONS Iron in other combinations
ATC	B03AE03	BLOOD AND BLOOD FORMING ORGANS ANTIANEMIC PREPARATIONS IRON PREPARATIONS Iron in other combinations
ATC	B03AE04	BLOOD AND BLOOD FORMING ORGANS ANTIANEMIC PREPARATIONS IRON PREPARATIONS Iron in other combinations
MeSH PA	D018977	Micronutrients
MeSH PA	D014131	Trace Elements
CHEBI has role	CHEBI:27027	trace elements
CHEBI has role	CHEBI:76971	Escherichia coli metabolites

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Anemia of prematurity	indication	47100003	DOID:11243
Megaloblastic anemia due to folate deficiency	indication	85649008	DOID:14026
Iron deficiency anemia	indication	87522002
Magnetic resonance imaging of liver	indication	241622002
Peptic ulcer	contraindication	13200003	DOID:750
Gastroenteritis	contraindication	25374005	DOID:2326
Hemosiderosis	contraindication	39011001	DOID:12119
Hemolytic anemia	contraindication	61261009	DOID:583
Ulcerative colitis	contraindication	64766004	DOID:8577
Diverticular disease	contraindication	397881000
Hemochromatosis	contraindication	399187006	DOID:2352
Repeated Blood Transfusions	contraindication

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

ID	Source
4017653	VUID
N0000146032	NUI
D09736	KEGG_DRUG
4017653	VANDF
4021247	VANDF
4021883	VANDF
C0337439	UMLSCUI
CHEBI:18248	CHEBI
D007501	MESH_DESCRIPTOR_UI
DB01592	DRUGBANK_ID
E1UOL152H7	UNII
23925	PUBCHEM_CID
262150	RXNORM
20159	MMSL
30873	MMSL
30874	MMSL
34448	MMSL
6958	MMSL
7441	MMSL
8219	MMSL
NOCODE	MMSL
d04432	MMSL
000828	NDDF
007431	NDDF
30729008	SNOMEDCT_US
32954005	SNOMEDCT_US
3829006	SNOMEDCT_US
714781004	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Ferralet 90	HUMAN PRESCRIPTION DRUG LABEL	5	0178-0089	TABLET, FILM COATED	90 mg	ORAL	unapproved drug other	17 sections
Ferralet 90	HUMAN PRESCRIPTION DRUG LABEL	5	0178-0089	TABLET, FILM COATED	90 mg	ORAL	unapproved drug other	17 sections
NataFort	HUMAN PRESCRIPTION DRUG LABEL	10	0178-0716	TABLET	60 mg	ORAL	Unapproved drug other	12 sections
CitraNatal Harmony 3.0	HUMAN PRESCRIPTION DRUG LABEL	8	0178-0796	CAPSULE, GELATIN COATED	27 mg	ORAL	unapproved drug other	10 sections
CitraNatal Harmony 3.0	HUMAN PRESCRIPTION DRUG LABEL	8	0178-0796	CAPSULE, GELATIN COATED	27 mg	ORAL	unapproved drug other	10 sections
Citranatal Harmony 2.1	HUMAN PRESCRIPTION DRUG LABEL	2	0178-0797	CAPSULE, GELATIN COATED	29 mg	ORAL	unapproved drug other	10 sections
CitraNatal 90 DHA	HUMAN PRESCRIPTION DRUG LABEL	16	0178-0821	TABLET	85 mg	ORAL	unapproved drug other	11 sections
CitraNatal 90 DHA	HUMAN PRESCRIPTION DRUG LABEL	16	0178-0821	TABLET	85 mg	ORAL	unapproved drug other	11 sections
CitraNatal 90 DHA	HUMAN OTC DRUG LABEL	14	0178-0829	TABLET	90 mg	ORAL	Unapproved drug other	11 sections
CitraNatal Rx	HUMAN PRESCRIPTION DRUG LABEL	13	0178-0858	TABLET	27 mg	ORAL	Unapproved drug other	12 sections
CitraNatal Rx	HUMAN PRESCRIPTION DRUG LABEL	14	0178-0859	TABLET	27 mg	ORAL	Unapproved drug other	9 sections
CitraNatal Medley	HUMAN PRESCRIPTION DRUG LABEL	8	0178-0896	CAPSULE, GELATIN COATED	27 mg	ORAL	unapproved drug other	10 sections
CitraNatal Medley	HUMAN PRESCRIPTION DRUG LABEL	8	0178-0896	CAPSULE, GELATIN COATED	27 mg	ORAL	unapproved drug other	10 sections
CitraNatal DHA	HUMAN OTC DRUG LABEL	14	0178-0898	TABLET	27 mg	ORAL	Unapproved drug other	11 sections
VitafolOne	HUMAN PRESCRIPTION DRUG LABEL	16	0642-0070	CAPSULE, GELATIN COATED	29 mg	ORAL	unapproved drug other	14 sections
Vitafol Caplet	HUMAN PRESCRIPTION DRUG LABEL	12	0642-0072	CAPSULE	27 mg	ORAL	UNAPPROVED DRUG OTHER	13 sections
Select OB	HUMAN PRESCRIPTION DRUG LABEL	15	0642-0077	TABLET, CHEWABLE	29 mg	ORAL	UNAPPROVED DRUG OTHER	14 sections
Vitafol OB Caplet	HUMAN PRESCRIPTION DRUG LABEL	15	0642-0079	TABLET	65 mg	ORAL	Unapproved drug other	14 sections
Vitafol OB Caplet	HUMAN PRESCRIPTION DRUG LABEL	15	0642-0079	TABLET	65 mg	ORAL	Unapproved drug other	14 sections
Vitafol Plus	HUMAN PRESCRIPTION DRUG LABEL	17	0642-0092	CAPSULE, LIQUID FILLED	27 mg	ORAL	UNAPPROVED DRUG OTHER	13 sections
Vitafol Ultra	HUMAN PRESCRIPTION DRUG LABEL	17	0642-0093	CAPSULE, LIQUID FILLED	29 mg	ORAL	UNAPPROVED DRUG OTHER	13 sections
Vitafol Ultra	HUMAN PRESCRIPTION DRUG LABEL	17	0642-0093	CAPSULE, LIQUID FILLED	29 mg	ORAL	UNAPPROVED DRUG OTHER	13 sections
Vitafol Nano	HUMAN PRESCRIPTION DRUG LABEL	7	0642-0094	TABLET, COATED	18 mg	ORAL	UNAPPROVED DRUG OTHER	14 sections
Vitafol Nano	HUMAN PRESCRIPTION DRUG LABEL	7	0642-0094	TABLET, COATED	18 mg	ORAL	UNAPPROVED DRUG OTHER	14 sections
Select OB	HUMAN PRESCRIPTION DRUG LABEL	15	0642-0120	TABLET, CHEWABLE	29 mg	ORAL	UNAPPROVED DRUG OTHER	13 sections
Strovite Forte Caplet	HUMAN PRESCRIPTION DRUG LABEL	19	0642-0204	TABLET, COATED	10 mg	ORAL	UNAPPROVED DRUG OTHER	15 sections
Reaphirm Plant Source DHA	HUMAN PRESCRIPTION DRUG LABEL	16	0642-3010	CAPSULE, GELATIN COATED	29 mg	ORAL	unapproved drug other	7 sections
Vitafol Fe Plus	HUMAN PRESCRIPTION DRUG LABEL	17	0642-7473	CAPSULE, LIQUID FILLED	90 mg	ORAL	UNAPPROVED DRUG OTHER	14 sections
Vitafol Fe Plus	HUMAN PRESCRIPTION DRUG LABEL	17	0642-7473	CAPSULE, LIQUID FILLED	90 mg	ORAL	UNAPPROVED DRUG OTHER	14 sections
Polysaccharide-Iron	HUMAN OTC DRUG LABEL	1	17714-077	CAPSULE	150 mg	ORAL	unapproved drug other	10 sections