sulfur 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 4260 | 7704-34-9 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
An element that is a member of the chalcogen family. It has an atomic symbol S, atomic number 16, and atomic weight [32.059; 32.076]. It is found in the amino acids cysteine and methionine.
|
Drug dosage:
None
ADMET properties:
None
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Sept. 17, 1940 | FDA | POYTHRESS |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Drug hypersensitivity | 118.25 | 15.23 | 133 | 4782 | 250877 | 50349332 |
| Exposure to toxic agent | 37.81 | 15.23 | 14 | 4901 | 3644 | 50596565 |
| Oesophagitis | 30.64 | 15.23 | 18 | 4897 | 13365 | 50586844 |
| Death | 20.75 | 15.23 | 74 | 4841 | 325305 | 50274904 |
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Exposure to toxic agent | 23.97 | 19.51 | 9 | 2717 | 2566 | 29569235 |
| Radiation oesophagitis | 19.52 | 19.51 | 5 | 2721 | 401 | 29571400 |
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Drug hypersensitivity | 113.46 | 15.47 | 120 | 5439 | 237695 | 64255478 |
| Exposure to toxic agent | 64.26 | 15.47 | 23 | 5536 | 6136 | 64487037 |
| Death | 46.10 | 15.47 | 117 | 5442 | 482588 | 64010585 |
| Oesophagitis | 18.16 | 15.47 | 15 | 5544 | 21615 | 64471558 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | D10AB02 | DERMATOLOGICALS ANTI-ACNE PREPARATIONS ANTI-ACNE PREPARATIONS FOR TOPICAL USE Preparations containing sulfur |
| CHEBI has role | CHEBI:33286 | agricultural chemicals |
| CHEBI has role | CHEBI:35718 | antifungal agents |
| CHEBI has role | CHEBI:75772 | S. cerevisiae metabolites |
| CHEBI has role | CHEBI:33937 | macronutrients |
Drug Use | Suggest Off label Use Form| |View source of the data|
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Greasy skin | indication | 42273000 | |
| Seborrheic dermatitis | indication | 50563003 | DOID:8741 |
| Acne vulgaris | indication | 88616000 | |
| Pityriasis simplex | indication | 200767005 | |
| Acute necrotizing ulcerative gingivitis | indication | 399050001 | |
| Acneiform eruption | indication | 402644006 | |
| Aphthous ulcer of mouth | indication | 426965005 | DOID:9663 |
| Rosacea | off-label use | 398909004 | DOID:8881 |
| Itching of skin | off-label use | 418363000 | |
| Infection of skin AND/OR subcutaneous tissue | contraindication | 19824006 | |
| Conduction disorder of the heart | contraindication | 44808001 | |
| Diabetes mellitus | contraindication | 73211009 | DOID:9351 |
| Decreased respiratory function | contraindication | 80954004 | |
| Kidney disease | contraindication | 90708001 | DOID:557 |
| Anemia due to enzyme deficiency | contraindication | 111577008 | |
| Deficiency of glucose-6-phosphate dehydrogenase | contraindication | 124134002 | DOID:2862 |
| Open wound | contraindication | 125643001 | |
| Seizure disorder | contraindication | 128613002 | |
| Condyloma acuminatum | contraindication | 240542006 | DOID:11168 |
| Telangiectasia disorder | contraindication | 247479008 | |
| Eruption of skin | contraindication | 271807003 | DOID:0050486 |
| Skin irritation | contraindication | 367466007 | |
| Adrenal cortical hypofunction | contraindication | 386584007 | DOID:10493 |
| Atrophoderma | contraindication | 399979006 | |
| Erythroderma | contraindication | 399992009 | |
| Peripheral vascular disease | contraindication | 400047006 | |
| Blister | contraindication | 417237009 | |
| Denuded skin | contraindication | 418242004 | |
| Inflammatory dermatosis | contraindication | 703938007 |
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
None
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Carbonic anhydrase 2 | Enzyme | Ki | 4.40 | CHEMBL | |||||
| Carbonic anhydrase 1 | Enzyme | Ki | 6.22 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4018870 | VUID |
| N0000147169 | NUI |
| D00024 | KEGG_DRUG |
| 4018870 | VANDF |
| C0038774 | UMLSCUI |
| CHEBI:26833 | CHEBI |
| CHEMBL2105487 | ChEMBL_ID |
| D013455 | MESH_DESCRIPTOR_UI |
| 70FD1KFU70 | UNII |
| 5362487 | PUBCHEM_CID |
| 10223 | RXNORM |
| 5415 | MMSL |
| 5534 | MMSL |
| NOCODE | MMSL |
| 002558 | NDDF |
| 002997 | NDDF |
| 332304007 | SNOMEDCT_US |
| 43735007 | SNOMEDCT_US |
| 10544-50-0 | SECONDARY_CAS_RN |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Avar-e Green | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0178-0460 | CREAM | 50 mg | TOPICAL | unapproved drug other | 13 sections |
| Avar-e LS | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0178-0465 | CREAM | 20 mg | TOPICAL | unapproved drug other | 12 sections |
| Avar-e | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0178-0470 | CREAM | 50 mg | TOPICAL | unapproved drug other | 12 sections |
| AVAR LS | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0178-0475 | EMULSION | 20 mg | TOPICAL | unapproved drug other | 12 sections |
| AVAR | HUMAN PRESCRIPTION DRUG LABEL | 2 | 0178-0480 | EMULSION | 50 mg | TOPICAL | unapproved drug other | 12 sections |
| Adult Acnomel Tinted | HUMAN OTC DRUG LABEL | 2 | 0295-9116 | CREAM | 8 g | TOPICAL | OTC monograph final | 12 sections |
| Sulfo lo | HUMAN OTC DRUG LABEL | 1 | 0316-0118 | SOAP | 30 mg | TOPICAL | OTC monograph final | 8 sections |
| Tinted Acne Treatment | HUMAN OTC DRUG LABEL | 2 | 0363-7783 | CREAM | 8 g | TOPICAL | OTC monograph final | 7 sections |
| Sebex Antidandruff, anti-seborrheic dermatitis, anti-psoriasis | HUMAN OTC DRUG LABEL | 2 | 0536-1962 | SHAMPOO | 20 mg | TOPICAL | OTC MONOGRAPH FINAL | 14 sections |
| Sulfur | HUMAN OTC DRUG LABEL | 1 | 10095-007 | OINTMENT | 10 g | TOPICAL | OTC monograph final | 8 sections |
| REZAMID | HUMAN OTC DRUG LABEL | 2 | 11086-022 | LOTION | 5 g | TOPICAL | OTC monograph final | 11 sections |
| LIQUIMAT ACNE TREATMENT AND COVER-UP | HUMAN OTC DRUG LABEL | 1 | 11086-028 | LIQUID | 3 g | TOPICAL | OTC monograph final | 11 sections |
| Kate Summerville EradiKate | HUMAN OTC DRUG LABEL | 1 | 11090-263 | CREAM | 3 g | TOPICAL | OTC monograph final | 11 sections |
| Sulfo lo | HUMAN OTC DRUG LABEL | 1 | 11118-0007 | SOAP | 30 mg | TOPICAL | OTC monograph final | 9 sections |
| Sulfur | HUMAN OTC DRUG LABEL | 1 | 11118-0009 | SOAP | 5 g | TOPICAL | OTC monograph final | 9 sections |
| Madina Acne | HUMAN OTC DRUG LABEL | 1 | 11118-0073 | SOAP | 3 g | TOPICAL | OTC monograph final | 9 sections |
| THYLOX | HUMAN OTC DRUG LABEL | 1 | 11118-1002 | SOAP | 3 g | TOPICAL | OTC monograph final | 9 sections |
| GRANDPAS THYLOX ACNE TREATMENT WITH SULFUR | HUMAN OTC DRUG LABEL | 1 | 11118-1006 | SOAP | 3 g | TOPICAL | OTC monograph final | 9 sections |
| PALMERS SKIN SUCCESS | HUMAN OTC DRUG LABEL | 1 | 11118-7386 | SOAP | 3 g | TOPICAL | OTC monograph final | 11 sections |
| Proactiv Skin Purifying Mask | HUMAN OTC DRUG LABEL | 1 | 11410-013 | LOTION | 6 g | TOPICAL | OTC MONOGRAPH FINAL | 13 sections |
| X Out Spot Corrector | HUMAN OTC DRUG LABEL | 1 | 11410-063 | LOTION | 6 g | TOPICAL | OTC MONOGRAPH FINAL | 13 sections |
| Proactiv Refining Mask | HUMAN OTC DRUG LABEL | 1 | 11410-507 | CREAM | 0.06 g | TOPICAL | OTC MONOGRAPH FINAL | 11 sections |
| Glovers Dandruff Control Medicine, Regular | HUMAN OTC DRUG LABEL | 1 | 12022-007 | SUSPENSION | 25 mg | TOPICAL | OTC monograph final | 10 sections |
| Glovers Dandruff Control Med., Floral | HUMAN OTC DRUG LABEL | 1 | 12022-008 | SUSPENSION | 25 mg | TOPICAL | OTC monograph final | 11 sections |
| Glovers Anti-Dandruff | HUMAN OTC DRUG LABEL | 2 | 12022-009 | OINTMENT | 50 mg | TOPICAL | OTC monograph final | 10 sections |
| Sulfur 8 Original Anti-Dandruff Hair and Scalp Conditioner | HUMAN OTC DRUG LABEL | 1 | 12022-017 | OINTMENT | 20 mg | TOPICAL | OTC monograph final | 10 sections |
| Sulfur 8 Light Anti-Dandruff Hair and Scalp Conditioner | HUMAN OTC DRUG LABEL | 1 | 12022-018 | OINTMENT | 20 mg | TOPICAL | OTC monograph final | 10 sections |
| Sulur 8 Kids Anti-Dandruff Hair and Scalp Conditioner | HUMAN OTC DRUG LABEL | 1 | 12022-022 | OINTMENT | 20 mg | TOPICAL | OTC monograph final | 10 sections |
| Sulfur 8 Scalp Therapy Medicated Dandruff Control Scalp Oil Serum | HUMAN OTC DRUG LABEL | 1 | 12022-034 | SUSPENSION | 25 mg | TOPICAL | OTC monograph final | 11 sections |
| Sulfur 8 Scalp Therapy Medicated Dandruff Control Scalp Butter Cream | HUMAN OTC DRUG LABEL | 2 | 12022-035 | OINTMENT | 50 mg | TOPICAL | OTC monograph final | 11 sections |