calcium carbonate 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
4239 471-34-1

Description:

MoleculeDescription

Synonyms:

  • calcium carbonate
  • carbonic acid calcium salt
Carbonic acid calcium salt (CaCO3). An odorless, tasteless powder or crystal that occurs in nature. It is used therapeutically as a phosphate buffer in hemodialysis patients and as a calcium supplement.
  • Molecular weight: 100.09
  • Formula: CCaO3
  • CLOGP:
  • LIPINSKI: None
  • HAC: None
  • HDO: None
  • TPSA:
  • ALOGS:
  • ROTB: None

Drug dosage:

DoseUnitRoute
3 g O

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

None

Approvals:

DateAgencyCompanyOrphan
Oct. 16, 2000 FDA MCNEIL CONS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pemphigus 1275.64 10.02 6590 907878 320274 89393705
Systemic lupus erythematosus 1264.42 10.02 7078 907390 354818 89359161
Completed suicide 1146.40 10.02 82 914386 144976 89569003
Glossodynia 1084.40 10.02 6234 908234 315545 89398434
Toxicity to various agents 933.57 10.02 916 913552 286930 89427049
Hand deformity 889.17 10.02 5571 908897 290791 89423188
Arthropathy 871.99 10.02 6503 907965 359739 89354240
Abdominal discomfort 823.89 10.02 7886 906582 469442 89244537
Alopecia 767.28 10.02 7999 906469 487072 89226907
Wound 723.18 10.02 5384 909084 297596 89416383
Synovitis 640.83 10.02 5591 908877 324161 89389818
Intentional overdose 624.67 10.02 99 914369 93735 89620244
Maternal exposure during pregnancy 600.51 10.02 5908 908560 354155 89359824
Pericarditis 590.07 10.02 4703 909765 265448 89448531
Anti-cyclic citrullinated peptide antibody positive 580.72 10.02 4231 910237 232202 89481777
Swelling 560.73 10.02 6579 907889 412479 89301500
Death 542.06 10.02 2565 911903 453986 89259993
Discomfort 512.38 10.02 4612 909856 269723 89444256
Duodenal ulcer perforation 468.15 10.02 3825 910643 217463 89496516
Contraindicated product administered 467.66 10.02 5114 909354 315025 89398954
Joint swelling 450.03 10.02 7354 907114 495946 89218033
Helicobacter infection 448.99 10.02 3863 910605 222987 89490992
Infusion related reaction 444.42 10.02 6276 908192 410504 89303475
Drug interaction 435.15 10.02 1386 913082 275067 89438912
Rheumatoid arthritis 404.13 10.02 5504 908964 357110 89356869
Suicide attempt 397.81 10.02 132 914336 75267 89638712
Drug abuse 388.24 10.02 172 914296 82175 89631804
Pain 372.06 10.02 12892 901576 983449 88730530
Rheumatoid factor positive 337.91 10.02 2920 911548 168730 89545249
Hepatic enzyme increased 320.52 10.02 5267 909201 355469 89358510
Psoriatic arthropathy 314.26 10.02 3606 910862 224729 89489250
Disease progression 305.85 10.02 706 913762 155909 89558070
Malignant neoplasm progression 301.23 10.02 381 914087 106489 89607490
Febrile neutropenia 292.47 10.02 735 913733 157614 89556365
Overdose 275.28 10.02 753 913715 156956 89557023
Arthralgia 267.86 10.02 9984 904484 768538 88945441
Cardiac arrest 261.02 10.02 409 914059 104526 89609453
Musculoskeletal stiffness 260.83 10.02 4323 910145 292209 89421770
Neutropenia 259.79 10.02 1275 913193 223629 89490350
Milk-alkali syndrome 258.94 10.02 161 914307 1112 89712867
Impaired healing 234.63 10.02 3490 910978 230709 89483270
Electrocardiogram QT prolonged 234.10 10.02 231 914237 72225 89641754
Hyperhidrosis 225.22 10.02 668 913800 135637 89578342
Product use issue 224.99 10.02 4623 909845 325296 89388683
Therapeutic product effect decreased 223.24 10.02 3989 910479 273582 89440397
Lactic acidosis 223.17 10.02 115 914353 50348 89663631
Drug ineffective for unapproved indication 221.69 10.02 207 914261 66437 89647542
Rheumatic fever 208.67 10.02 2414 912054 150707 89563272
Acute kidney injury 207.32 10.02 2148 912320 318239 89395740
Folliculitis 204.95 10.02 3046 911422 201307 89512672
Myelosuppression 199.77 10.02 149 914319 53442 89660537
Somnolence 193.51 10.02 1274 913194 207810 89506169
Depressed level of consciousness 190.38 10.02 274 914194 72510 89641469
Bradycardia 187.25 10.02 350 914118 83497 89630482
Hypotension 186.25 10.02 2243 912225 323154 89390825
Nasopharyngitis 184.86 10.02 5397 909071 401707 89312272
Blister 183.69 10.02 3603 910865 251395 89462584
Drug reaction with eosinophilia and systemic symptoms 176.71 10.02 106 914362 42652 89671327
Off label use 171.03 10.02 9240 905228 1093012 88620967
Muscle injury 167.01 10.02 2607 911861 174047 89539932
Swollen joint count increased 166.43 10.02 1786 912682 109420 89604559
Irritable bowel syndrome 164.48 10.02 2975 911493 204473 89509506
Sleep disorder due to general medical condition, insomnia type 162.61 10.02 2000 912468 126694 89587285
Hip arthroplasty 160.77 10.02 1317 913151 74891 89639088
Serotonin syndrome 160.72 10.02 91 914377 37796 89676183
Knee arthroplasty 157.83 10.02 1404 913064 81778 89632201
Intentional product misuse 156.92 10.02 427 914041 89177 89624802
Drug intolerance 153.62 10.02 5741 908727 441850 89272129
Drug resistance 152.58 10.02 58 914410 30391 89683588
Fibromyalgia 152.07 10.02 2925 911543 203344 89510635
Hyponatraemia 151.28 10.02 762 913706 132776 89581203
Agitation 150.79 10.02 279 914189 66819 89647160
Lower respiratory tract infection 150.16 10.02 3448 911020 247211 89466768
No adverse event 147.24 10.02 289 914179 67693 89646286
Sopor 147.04 10.02 34 914434 24610 89689369
Exposure during pregnancy 144.83 10.02 3286 911182 235124 89478855
Type 2 diabetes mellitus 144.72 10.02 2867 911601 200377 89513602
Constipation 144.04 10.02 1977 912491 278418 89435561
Cardiac failure 142.36 10.02 594 913874 108902 89605077
C-reactive protein abnormal 140.69 10.02 1932 912536 125497 89588482
Angioedema 140.33 10.02 276 914192 64600 89649379
Device expulsion 139.54 10.02 124 914344 40762 89673217
Rhabdomyolysis 136.98 10.02 190 914278 51066 89662913
Tremor 135.86 10.02 945 913523 152228 89561751
Intentional self-injury 135.55 10.02 63 914405 29271 89684708
Blood cholesterol increased 135.52 10.02 2896 911572 205116 89508863
Nausea 134.90 10.02 9520 904948 1100796 88613183
Coma 132.60 10.02 339 914129 72293 89641686
Thrombocytopenia 129.80 10.02 1412 913056 207313 89506666
Red blood cell sedimentation rate abnormal 128.81 10.02 535 913933 23669 89690310
Accidental exposure to product 127.93 10.02 143 914325 42223 89671756
Respiratory arrest 127.56 10.02 90 914378 33221 89680758
Hepatic function abnormal 127.33 10.02 168 914300 46120 89667859
Sedation 127.30 10.02 180 914288 47991 89665988
Hypersensitivity 125.97 10.02 5701 908767 448976 89265003
Contusion 125.51 10.02 3372 911096 247844 89466135
Respiratory failure 125.04 10.02 692 913776 117726 89596253
Ill-defined disorder 124.29 10.02 2586 911882 182305 89531674
Anaphylactic reaction 123.20 10.02 460 914008 87064 89626915
Osteoarthritis 122.70 10.02 2710 911758 193020 89520959
COVID-19 122.21 10.02 1101 913367 167742 89546237
Syncope 121.86 10.02 810 913658 131853 89582126
Tachycardia 121.76 10.02 1011 913457 156662 89557317
Cardio-respiratory arrest 119.71 10.02 289 914179 62851 89651128
Sickle cell anaemia with crisis 118.41 10.02 241 914227 7056 89706923
Hypoglycaemia 117.02 10.02 340 914128 69508 89644471
Liver injury 115.41 10.02 2388 912080 168179 89545800
Diarrhoea 114.85 10.02 8047 906421 931143 88782836
Neoplasm progression 110.02 10.02 174 914294 44312 89669667
Multiple organ dysfunction syndrome 109.90 10.02 339 914129 67997 89645982
Neuropathy peripheral 109.08 10.02 871 913597 136099 89577880
Metabolic acidosis 108.62 10.02 251 914217 55425 89658554
Hepatic failure 108.45 10.02 145 914323 39583 89674396
Temperature regulation disorder 107.59 10.02 11 914457 14568 89699411
Food allergy 106.92 10.02 62 914406 25416 89688563
Product dose omission issue 106.46 10.02 2189 912279 289498 89424481
Multiple sclerosis relapse 105.96 10.02 231 914237 52074 89661905
Treatment failure 105.26 10.02 3903 910565 300025 89413954
Stomatitis 104.60 10.02 3566 910902 271132 89442847
Renal impairment 103.83 10.02 630 913838 104791 89609188
Fatigue 103.33 10.02 13219 901249 1140804 88573175
Neutrophil count decreased 102.61 10.02 373 914095 71159 89642820
Joint range of motion decreased 102.49 10.02 1931 912537 133712 89580267
Renal failure 101.61 10.02 839 913629 130168 89583811
Hypoxia 100.93 10.02 382 914086 72017 89641962
Vision blurred 99.50 10.02 677 913791 109616 89604363
Drug withdrawal syndrome 98.15 10.02 87 914381 28636 89685343
Shock 97.34 10.02 88 914380 28690 89685289
Hepatocellular injury 96.23 10.02 90 914378 28868 89685111
Arthritis 95.66 10.02 2287 912181 165028 89548951
Facet joint syndrome 95.23 10.02 1458 913010 96931 89617048
Dry skin 94.99 10.02 511 913957 87562 89626417
Altered state of consciousness 94.59 10.02 107 914361 31425 89682554
Anaemia 94.53 10.02 2773 911695 350029 89363950
Wrong technique in product usage process 94.43 10.02 386 914082 71185 89642794
Seizure 94.27 10.02 1034 913434 151595 89562384
Dyspnoea 94.12 10.02 7633 906835 873322 88840657
Injury 93.46 10.02 2631 911837 194718 89519261
Sinusitis 93.44 10.02 4295 910173 338793 89375186
Mydriasis 93.04 10.02 19 914449 14993 89698986
Pregnancy 91.64 10.02 994 913474 61053 89652926
Suicidal ideation 90.90 10.02 409 914059 73446 89640533
Anaphylactic shock 90.86 10.02 111 914357 31506 89682473
Product use in unapproved indication 89.53 10.02 2645 911823 333591 89380388
Restlessness 89.01 10.02 139 914329 35581 89678398
Palmar-plantar erythrodysaesthesia syndrome 88.61 10.02 91 914377 27932 89686047
Drug dependence 87.45 10.02 100 914368 29227 89684752
Blood glucose increased 85.73 10.02 585 913883 94661 89619318
Live birth 83.90 10.02 1191 913277 77916 89636063
Cytomegalovirus infection 82.30 10.02 88 914380 26514 89687465
Intentional product use issue 82.13 10.02 2814 911654 214078 89499901
Flushing 81.90 10.02 539 913929 87952 89626027
Metastases to bone 80.45 10.02 83 914385 25422 89688557
Disturbance in attention 79.87 10.02 228 914240 46881 89667098
Grip strength decreased 79.16 10.02 1344 913124 91232 89622747
Device difficult to use 78.89 10.02 39 914429 17486 89696493
Hallucination 78.37 10.02 370 914098 65589 89648390
Myalgia 77.72 10.02 1270 913198 173855 89540124
Mobility decreased 77.61 10.02 3181 911287 247553 89466426
Platelet count decreased 77.17 10.02 947 913521 136022 89577957
Cytokine release syndrome 76.45 10.02 102 914366 27871 89686108
Torsade de pointes 75.93 10.02 29 914439 15153 89698826
Respiratory depression 75.84 10.02 31 914437 15544 89698435
Encephalopathy 75.68 10.02 229 914239 46215 89667764
Cholestasis 75.45 10.02 158 914310 36141 89677838
Acute hepatic failure 75.11 10.02 70 914398 22491 89691488
Hyperglycaemia 74.95 10.02 263 914205 50707 89663272
Blood pressure diastolic abnormal 73.26 10.02 395 914073 19486 89694493
Erythema 73.14 10.02 1757 912711 227489 89486490
Diabetic ketoacidosis 73.02 10.02 83 914385 24324 89689655
Weight increased 72.72 10.02 5022 909446 412905 89301074
Lip dry 72.43 10.02 1426 913042 99529 89614450
Pulmonary fibrosis 72.33 10.02 1504 912964 105999 89607980
Feeling abnormal 72.17 10.02 1219 913249 166016 89547963
Cardiac failure congestive 72.08 10.02 642 913826 98052 89615927
Ventricular tachycardia 71.79 10.02 86 914382 24622 89689357
Inflammation 71.66 10.02 2333 912135 176259 89537720
Poisoning 71.37 10.02 32 914436 15185 89698794
Dermatitis atopic 71.12 10.02 79 914389 23393 89690586
Blood pressure systolic abnormal 70.43 10.02 385 914083 19093 89694886
Therapy partial responder 70.36 10.02 71 914397 21972 89692007
Recalled product 69.96 10.02 78 914390 1310 89712669
Blood pressure systolic increased 69.93 10.02 898 913570 57447 89656532
Myocardial infarction 69.86 10.02 707 913761 105265 89608714
Disability assessment scale score increased 68.80 10.02 134 914334 3797 89710182
Exposure to toxic agent 67.53 10.02 3 914465 7964 89706015
General physical health deterioration 67.07 10.02 4297 910171 350818 89363161
Disease recurrence 66.99 10.02 178 914290 37475 89676504
Withdrawal syndrome 66.95 10.02 77 914391 22447 89691532
Deep vein thrombosis postoperative 65.73 10.02 1042 913426 69767 89644212
Leukopenia 65.52 10.02 674 913794 100036 89613943
Exposure via skin contact 65.42 10.02 14 914454 10691 89703288
Sepsis 65.38 10.02 1350 913118 178464 89535515
Dehydration 65.17 10.02 1479 912989 192968 89521011
Peripheral swelling 64.84 10.02 4923 909545 408183 89305796
Loss of consciousness 64.55 10.02 1010 913458 139228 89574751
Chest discomfort 64.54 10.02 994 913474 137371 89576608
Ejection fraction decreased 63.68 10.02 104 914364 26149 89687830
Joint effusion 63.65 10.02 378 914090 19332 89694647
Drug level increased 62.76 10.02 115 914353 27647 89686332
Cognitive disorder 62.60 10.02 426 914042 68981 89644998
Blood pressure decreased 61.13 10.02 473 913995 74422 89639557
Foot deformity 60.84 10.02 892 913576 58759 89655220
Fluid retention 60.45 10.02 582 913886 87509 89626470
Akathisia 59.79 10.02 19 914449 11140 89702839
Hyperkalaemia 58.96 10.02 398 914070 64566 89649413
Extrapyramidal disorder 58.63 10.02 47 914421 16256 89697723
White blood cell count decreased 58.30 10.02 1263 913205 165846 89548133
Psoriasis 58.19 10.02 1926 912542 145828 89568151
Parkinsonism 57.93 10.02 35 914433 14030 89699949
Condition aggravated 57.83 10.02 6859 907609 588686 89125293
Metastases to liver 57.71 10.02 128 914340 28679 89685300
Brain oedema 56.64 10.02 55 914413 17330 89696649
Musculoskeletal pain 56.31 10.02 2187 912281 169064 89544915
Toxic skin eruption 56.07 10.02 46 914422 15728 89698251
Drug hypersensitivity 55.95 10.02 3975 910493 459634 89254345
Ascites 55.43 10.02 270 914198 47470 89666509
Disseminated intravascular coagulation 55.41 10.02 82 914386 21456 89692523
Eczema 55.22 10.02 310 914158 52560 89661419
Gamma-glutamyltransferase increased 55.02 10.02 197 914271 37755 89676224
Miosis 54.79 10.02 14 914454 9470 89704509
Anxiety 54.57 10.02 2561 911907 307211 89406768
Dizziness 54.47 10.02 5162 909306 584122 89129857
Headache 54.14 10.02 7757 906711 854989 88858990
Osteoporosis 54.09 10.02 1316 913152 95215 89618764
C-reactive protein increased 54.00 10.02 2292 912176 179097 89534882
Stevens-Johnson syndrome 53.69 10.02 137 914331 29239 89684740
Wound infection 53.58 10.02 1430 913038 104972 89609007
Bone erosion 53.34 10.02 791 913677 52230 89661749
Metastases to central nervous system 53.19 10.02 59 914409 17483 89696496
Cerebral haemorrhage 52.89 10.02 175 914293 34347 89679632
Post transplant lymphoproliferative disorder 51.92 10.02 5 914463 6944 89707035
Irritability 51.78 10.02 185 914283 35477 89678502
Blood creatine phosphokinase increased 51.76 10.02 173 914295 33850 89680129
Bronchospasm 51.21 10.02 81 914387 20628 89693351
Alanine aminotransferase increased 50.91 10.02 863 913605 117475 89596504
Dystonia 50.53 10.02 57 914411 16762 89697217
Swollen tongue 50.46 10.02 265 914203 45691 89668288
Blood pressure fluctuation 50.43 10.02 776 913692 51637 89662342
Polyneuropathy 50.38 10.02 73 914395 19268 89694711
Dislocation of vertebra 49.84 10.02 818 913650 55150 89658829
Aggression 49.81 10.02 123 914345 26545 89687434
Disorientation 49.78 10.02 252 914216 43862 89670117
Sciatica 49.76 10.02 1358 913110 100024 89613955
Gait inability 49.72 10.02 1877 912591 144579 89569400
Rash erythematous 49.53 10.02 419 914049 64685 89649294
Juvenile idiopathic arthritis 49.41 10.02 118 914350 3859 89710120
Vertigo 49.28 10.02 458 914010 69353 89644626
Haematotoxicity 49.15 10.02 33 914435 12502 89701477
Abortion spontaneous 48.86 10.02 792 913676 53264 89660715
Aspartate aminotransferase increased 48.85 10.02 737 913731 102200 89611779
Hypercholesterolaemia 48.83 10.02 1349 913119 99543 89614436
Thrombotic microangiopathy 48.79 10.02 52 914416 15691 89698288
Adjustment disorder with depressed mood 48.53 10.02 824 913644 55929 89658050
Inappropriate antidiuretic hormone secretion 48.50 10.02 76 914392 19429 89694550
Hospitalisation 48.27 10.02 956 913512 127144 89586835
Gastrointestinal disorder 48.06 10.02 3104 911364 253583 89460396
Shunt stenosis 47.97 10.02 42 914426 517 89713462
Neuroleptic malignant syndrome 47.75 10.02 49 914419 15047 89698932
Hypothermia 47.65 10.02 52 914416 15523 89698456
Dyskinesia 47.59 10.02 198 914270 36336 89677643
Back pain 47.49 10.02 2666 911802 314509 89399470
Femur fracture 46.95 10.02 689 913779 45393 89668586
Speech disorder 46.68 10.02 269 914199 45316 89668663
Autoimmune disorder 46.60 10.02 1058 913410 75686 89638293
Obesity 46.45 10.02 1394 913074 104113 89609866
Peripheral venous disease 46.39 10.02 1142 913326 82779 89631200
Face oedema 46.39 10.02 104 914364 23214 89690765
Abnormal behaviour 45.77 10.02 100 914368 22528 89691451
Joint destruction 45.62 10.02 259 914209 13028 89700951
Joint laxity 45.28 10.02 89 914379 2539 89711440
Eye pruritus 45.26 10.02 146 914322 28881 89685098
Ventricular fibrillation 45.09 10.02 45 914423 13999 89699980
Red blood cell sedimentation rate increased 45.07 10.02 1122 913346 81473 89632506
Asthenia 45.07 10.02 4706 909762 529045 89184934
Bronchopulmonary aspergillosis 44.70 10.02 30 914438 11368 89702611
Acute myeloid leukaemia 44.46 10.02 88 914380 20552 89693427
Lower limb fracture 44.38 10.02 1148 913320 83865 89630114
Drug dose omission by device 44.22 10.02 24 914444 10207 89703772
Illness 44.19 10.02 572 913896 81397 89632582
Polyarthritis 44.15 10.02 327 914141 18023 89695956
Posterior reversible encephalopathy syndrome 44.14 10.02 100 914368 22239 89691740
Basal cell carcinoma 43.93 10.02 523 913945 32866 89681113
Acute generalised exanthematous pustulosis 43.89 10.02 44 914424 13659 89700320
Breast cancer stage III 43.69 10.02 1139 913329 83308 89630671
Lymphocyte count decreased 43.18 10.02 194 914274 34856 89679123
Arrhythmia 42.71 10.02 251 914217 42081 89671898
Hypokalaemia 42.04 10.02 1004 913464 130112 89583867
Cardiotoxicity 42.01 10.02 32 914436 11357 89702622
Metastases to lung 42.00 10.02 60 914408 15931 89698048
Pulmonary embolism 41.87 10.02 1002 913466 129818 89584161
Joint stiffness 41.36 10.02 1056 913412 76986 89636993
Rash 41.17 10.02 8856 905612 787244 88926735
Respiratory distress 40.87 10.02 228 914240 38718 89675261
Tachypnoea 40.81 10.02 97 914371 21212 89692767
Haemophagocytic lymphohistiocytosis 40.61 10.02 58 914410 15401 89698578
Pulmonary oedema 40.57 10.02 415 914053 61665 89652314
Road traffic accident 40.36 10.02 1395 913073 106231 89607748
Multiple-drug resistance 40.34 10.02 14 914454 7762 89706217
Hypercalcaemia 40.19 10.02 525 913943 33715 89680264
Gestational diabetes 40.18 10.02 212 914256 10370 89703609
Proteinuria 40.01 10.02 112 914356 23179 89690800
Tardive dyskinesia 39.95 10.02 31 914437 10899 89703080
Mucosal inflammation 39.84 10.02 380 914088 57245 89656734
Cytopenia 39.69 10.02 72 914396 17377 89696602
Neurotoxicity 39.32 10.02 100 914368 21367 89692612
Stress cardiomyopathy 39.32 10.02 46 914422 13309 89700670
Acute respiratory distress syndrome 38.92 10.02 153 914315 28533 89685446
Hepatic cytolysis 38.76 10.02 170 914298 30746 89683233
Bursitis 38.60 10.02 1661 912807 129993 89583986
Inappropriate schedule of product administration 38.47 10.02 1185 913283 148748 89565231
Vomiting 38.26 10.02 7190 907278 781103 88932876
Atrioventricular block complete 38.24 10.02 26 914442 9785 89704194
Cardiogenic shock 38.20 10.02 123 914345 24345 89689634
Coagulopathy 37.82 10.02 115 914353 23174 89690805
Paralysis 37.75 10.02 36 914432 11442 89702537
Status epilepticus 37.69 10.02 84 914384 18790 89695189
Balance disorder 37.64 10.02 721 913747 96359 89617620
Infection 37.59 10.02 4189 910279 357905 89356074
Blood pressure diastolic decreased 36.98 10.02 424 914044 26402 89687577
Nightmare 36.93 10.02 105 914363 21620 89692359
Acute graft versus host disease in skin 36.67 10.02 3 914465 4753 89709226
Pancreatitis acute 36.49 10.02 183 914285 31932 89682047
Complication of device insertion 36.40 10.02 31 914437 10405 89703574
Prescribed underdose 36.28 10.02 1003 913465 74016 89639963
Premature labour 36.05 10.02 245 914223 13131 89700848
Second primary malignancy 35.99 10.02 31 914437 10347 89703632
Multiple fractures 35.92 10.02 191 914277 9371 89704608
Acute graft versus host disease 35.86 10.02 6 914462 5462 89708517
Tinnitus 35.74 10.02 271 914197 42831 89671148
Foetal exposure during pregnancy 35.68 10.02 621 913847 42354 89671625
Device dislocation 35.43 10.02 180 914288 31302 89682677
Graft versus host disease 35.35 10.02 19 914449 8125 89705854
Palpitations 35.24 10.02 1080 913388 135648 89578331
Erythema multiforme 35.18 10.02 43 914425 12203 89701776
Product preparation error 35.16 10.02 31 914437 10230 89703749
Wheezing 34.79 10.02 2822 911646 235258 89478721
Complication of device removal 34.69 10.02 10 914458 6245 89707734
Sinus tachycardia 34.42 10.02 159 914309 28354 89685625
Paradoxical drug reaction 34.31 10.02 8 914460 5758 89708221
Atrial fibrillation 34.28 10.02 1056 913412 132555 89581424
BK virus infection 34.24 10.02 3 914465 4495 89709484
Bradyphrenia 34.17 10.02 17 914451 7595 89706384
Myocarditis 34.14 10.02 54 914414 13752 89700227
Genital haemorrhage 34.00 10.02 23 914445 8679 89705300
Caesarean section 33.91 10.02 311 914157 18266 89695713
Febrile bone marrow aplasia 33.87 10.02 29 914439 9709 89704270
Unresponsive to stimuli 33.87 10.02 235 914233 37886 89676093
Infusion site pain 33.85 10.02 95 914373 19643 89694336
Rebound effect 33.81 10.02 27 914441 9357 89704622
Myoclonus 33.81 10.02 91 914377 19077 89694902
Urinary retention 33.37 10.02 233 914235 37511 89676468
Accidental overdose 33.34 10.02 159 914309 28114 89685865
Eosinophilia 33.34 10.02 161 914307 28372 89685607
Haemorrhage intracranial 33.22 10.02 64 914404 15098 89698881
Product administered to patient of inappropriate age 33.10 10.02 4 914464 4649 89709330
Circulatory collapse 33.04 10.02 134 914334 24770 89689209
Pain in jaw 32.93 10.02 317 914151 47668 89666311
Cerebral infarction 32.89 10.02 147 914321 26449 89687530
Epistaxis 32.76 10.02 633 913835 84492 89629487
Psychomotor hyperactivity 32.75 10.02 49 914419 12764 89701215
Jaundice 32.70 10.02 193 914275 32324 89681655
Device use error 32.61 10.02 16 914452 7205 89706774
Emotional distress 32.57 10.02 226 914242 36436 89677543
Pulmonary arterial hypertension 32.23 10.02 145 914323 26042 89687937
Lethargy 32.07 10.02 446 914022 62693 89651286
Interstitial lung disease 31.95 10.02 560 913908 75845 89638134
Neck deformity 31.69 10.02 69 914399 2120 89711859
Mania 31.49 10.02 59 914409 14065 89699914
Adverse event 31.48 10.02 1468 913000 115950 89598029
Orthostatic hypotension 31.45 10.02 270 914198 41557 89672422
Haemorrhage 31.44 10.02 501 913967 68868 89645111
Substance abuse 31.19 10.02 8 914460 5398 89708581
Epstein-Barr virus infection 31.14 10.02 35 914433 10309 89703670
Pathogen resistance 30.97 10.02 22 914446 8093 89705886
Small for dates baby 30.94 10.02 116 914352 4891 89709088
Ketoacidosis 30.93 10.02 9 914459 5586 89708393
Product administration error 30.93 10.02 149 914319 26274 89687705
Pruritus 30.91 10.02 4895 909573 536630 89177349
Blood alkaline phosphatase increased 30.76 10.02 323 914145 47756 89666223
Heart rate decreased 30.75 10.02 732 913736 52773 89661206
Pain in extremity 30.70 10.02 5083 909385 445446 89268533
Graft versus host disease in gastrointestinal tract 30.66 10.02 4 914464 4384 89709595
Cough 30.58 10.02 3257 911211 365705 89348274
Hypothyroidism 30.41 10.02 366 914102 52761 89661218
Incorrect dose administered 30.35 10.02 587 913881 78343 89635636
Product prescribing issue 29.97 10.02 22 914446 7957 89706022
Labelled drug-drug interaction medication error 29.86 10.02 64 914404 14518 89699461
Lupus-like syndrome 29.84 10.02 674 913794 48172 89665807
Pseudomonas infection 29.82 10.02 66 914402 14799 89699180
Muscle twitching 29.79 10.02 134 914334 24068 89689911
Hypocalcaemia 29.56 10.02 596 913872 41772 89672207
Depressed mood 29.51 10.02 344 914124 49878 89664101
C-reactive protein 28.88 10.02 461 914007 30906 89683073
Blood creatinine increased 28.85 10.02 790 913678 100596 89613383
Pleural effusion 28.51 10.02 886 913582 111105 89602874
Panic attack 28.40 10.02 153 914315 26212 89687767
Haemoptysis 28.34 10.02 208 914260 33112 89680867
Shunt occlusion 28.33 10.02 37 914431 738 89713241
Maternal drugs affecting foetus 28.26 10.02 115 914353 5040 89708939
Graft versus host disease in skin 28.19 10.02 3 914465 3850 89710129
Tumour lysis syndrome 28.16 10.02 43 914425 11109 89702870
Dysgeusia 27.88 10.02 368 914100 52192 89661787
Bradykinesia 27.81 10.02 17 914451 6771 89707208
Dysphagia 27.69 10.02 892 913576 111386 89602593
Dry mouth 27.58 10.02 2186 912282 181873 89532106
Swelling face 27.46 10.02 618 913850 80734 89633245
Cytomegalovirus infection reactivation 27.41 10.02 23 914445 7777 89706202
Anti-cyclic citrullinated peptide antibody 27.34 10.02 406 914062 26815 89687164
Dissociation 27.25 10.02 17 914451 6698 89707281
X-ray abnormal 27.19 10.02 625 913843 44799 89669180
Joint dislocation 27.18 10.02 615 913853 43967 89670012
Tuberculosis 27.06 10.02 218 914250 12331 89701648
Middle insomnia 27.00 10.02 83 914385 16668 89697311
Melaena 26.89 10.02 223 914245 34574 89679405
Wheelchair user 26.89 10.02 152 914316 7633 89706346
Nasal obstruction 26.72 10.02 72 914396 2540 89711439
Tenderness 26.70 10.02 400 914068 26468 89687511
Bradypnoea 26.67 10.02 7 914461 4651 89709328
Sinus bradycardia 26.61 10.02 85 914383 16867 89697112
Hallucination, visual 26.57 10.02 131 914337 22961 89691018
Therapy interrupted 26.51 10.02 351 914117 49757 89664222
Jaundice cholestatic 26.50 10.02 183 914285 9860 89704119
Mental disorder 26.41 10.02 204 914264 32114 89681865
Laryngitis 26.38 10.02 685 913783 50068 89663911
Right ventricular failure 26.33 10.02 102 914366 19103 89694876
Pulmonary hypertension 26.27 10.02 288 914180 42235 89671744
Drug tolerance decreased 26.21 10.02 463 914005 31667 89682312
Product prescribing error 26.21 10.02 187 914281 29958 89684021
Sleep apnoea syndrome 26.13 10.02 200 914268 31547 89682432
Transplant rejection 26.12 10.02 56 914412 12702 89701277
Breast cancer female 26.01 10.02 71 914397 14815 89699164
Maternal exposure before pregnancy 25.95 10.02 198 914270 11015 89702964
Central nervous system lupus 25.75 10.02 48 914420 1315 89712664
Therapeutic response shortened 25.64 10.02 131 914337 22748 89691231
Crohn's disease 25.63 10.02 107 914361 4744 89709235
Latent tuberculosis 25.54 10.02 77 914391 2899 89711080
Myopathy 25.52 10.02 62 914406 13456 89700523
Mental status changes 25.49 10.02 308 914160 44371 89669608
Dysmorphism 25.48 10.02 70 914398 2498 89711481
Colitis microscopic 25.42 10.02 46 914422 11113 89702866
Nephrocalcinosis 25.32 10.02 45 914423 1187 89712792
Nicotine dependence 25.08 10.02 41 914427 1009 89712970
Skin toxicity 25.07 10.02 19 914449 6760 89707219
Oedema 25.04 10.02 2347 912121 197948 89516031
Sleep terror 25.01 10.02 7 914461 4457 89709522
Rash maculo-papular 24.98 10.02 278 914190 40655 89673324
Dyspepsia 24.92 10.02 2323 912145 195837 89518142
Osteonecrosis of jaw 24.89 10.02 263 914205 38840 89675139
Nodule 24.87 10.02 393 914075 26293 89687686
Crying 24.85 10.02 154 914314 25491 89688488
Eye irritation 24.81 10.02 221 914247 33757 89680222
Drug effective for unapproved indication 24.71 10.02 26 914442 7892 89706087
Chills 24.65 10.02 1084 913384 130897 89583082
Throat tightness 24.62 10.02 185 914283 29299 89684680
Pallor 24.60 10.02 223 914245 33942 89680037
Forced expiratory volume decreased 24.56 10.02 14 914454 5794 89708185
Deep vein thrombosis 24.52 10.02 720 913748 90900 89623079
Dyspnoea exertional 24.44 10.02 549 913919 71739 89642240
Nasal oedema 24.38 10.02 131 914337 6453 89707526
Product storage error 24.36 10.02 113 914355 20128 89693851
Sexual dysfunction 24.32 10.02 9 914459 4795 89709184
Aspergillus infection 24.31 10.02 45 914423 10778 89703201
Immune reconstitution inflammatory syndrome 24.30 10.02 21 914447 6998 89706981
Body temperature decreased 24.23 10.02 356 914112 23460 89690519
Electrocardiogram QRS complex prolonged 24.22 10.02 23 914445 7325 89706654
Disability 24.20 10.02 560 913908 40185 89673794
Chronic graft versus host disease 24.12 10.02 6 914462 4133 89709846
Hypomania 24 10.02 163 914305 8734 89705245
Blindness 23.99 10.02 163 914305 26405 89687574
Hypophosphataemic osteomalacia 23.86 10.02 20 914448 231 89713748
Bone marrow failure 23.78 10.02 209 914259 32012 89681967
Colitis 23.69 10.02 531 913937 69411 89644568
Agranulocytosis 23.69 10.02 232 914236 34770 89679209
Acute respiratory failure 23.68 10.02 298 914170 42620 89671359
Ischaemic stroke 23.68 10.02 129 914339 22037 89691942
Exostosis 23.64 10.02 703 913765 52431 89661548
Injection site reaction 23.57 10.02 1146 913322 90934 89623045
Cytomegalovirus viraemia 23.57 10.02 25 914443 7561 89706418
Haematoma 23.51 10.02 266 914202 38782 89675197
Metastases to lymph nodes 23.36 10.02 52 914416 11637 89702342
Gastrointestinal haemorrhage 23.21 10.02 713 913755 89535 89624444
Atrial tachycardia 23.18 10.02 16 914452 5974 89708005
Ventricular septal defect 23.11 10.02 112 914356 5295 89708684
Aspiration 23.05 10.02 81 914387 15612 89698367
Respiratory acidosis 22.81 10.02 29 914439 8090 89705889
Anuria 22.78 10.02 75 914393 14743 89699236
Hepatic cirrhosis 22.75 10.02 816 913652 62437 89651542
Fracture delayed union 22.61 10.02 66 914402 2440 89711539
Pericardial effusion 22.54 10.02 250 914218 36583 89677396
Carotid artery thrombosis 22.43 10.02 163 914305 8929 89705050
Acute chest syndrome 22.41 10.02 41 914427 1107 89712872
Schizoaffective disorder 22.36 10.02 12 914456 5135 89708844
Product adhesion issue 22.32 10.02 12 914456 5130 89708849
Muscle rigidity 22.29 10.02 72 914396 14237 89699742
Body temperature increased 22.29 10.02 317 914151 44393 89669586
Premature rupture of membranes 22.25 10.02 113 914355 5445 89708534
Loss of personal independence in daily activities 22.14 10.02 1627 912841 134478 89579501
Subarachnoid haemorrhage 22.11 10.02 99 914369 17805 89696174
Lip swelling 22.09 10.02 266 914202 38344 89675635
Device issue 22.06 10.02 191 914277 29346 89684633
Onychomycosis 21.98 10.02 513 913955 36863 89677116
Infusion site erythema 21.84 10.02 68 914400 13602 89700377
Mood altered 21.66 10.02 94 914374 17050 89696929
Polyhydramnios 21.62 10.02 65 914403 2443 89711536
Hypoaesthesia 21.60 10.02 3547 910921 310663 89403316
Urinary incontinence 21.42 10.02 259 914209 37307 89676672
Hepatic necrosis 21.40 10.02 20 914448 6418 89707561
Transaminases increased 21.37 10.02 256 914212 36936 89677043
Lymphopenia 21.35 10.02 139 914329 22742 89691237
Adenovirus infection 21.24 10.02 10 914458 4612 89709367
Dysuria 21.21 10.02 275 914193 39126 89674853
Sputum purulent 21.17 10.02 44 914424 1308 89712671
Heart rate increased 21.15 10.02 927 913541 111975 89602004
Glycosylated haemoglobin increased 21.11 10.02 83 914385 15479 89698500
Pulseless electrical activity 21.09 10.02 36 914432 8896 89705083
Fear 21.08 10.02 91 914377 16531 89697448
Anti-neutrophil cytoplasmic antibody positive vasculitis 21.04 10.02 7 914461 3986 89709993
Device breakage 20.96 10.02 72 914396 13972 89700007
Neurologic neglect syndrome 20.91 10.02 157 914311 8690 89705289
Cardiomyopathy 20.82 10.02 119 914349 20087 89693892
Pulmonary congestion 20.81 10.02 113 914355 19320 89694659
Respiration abnormal 20.80 10.02 30 914438 7933 89706046
Salivary gland calculus 20.73 10.02 17 914451 190 89713789
Affective disorder 20.71 10.02 29 914439 7764 89706215
Hyperthermia 20.64 10.02 46 914422 10289 89703690
Delusion 20.62 10.02 71 914397 13769 89700210
Rotator cuff repair 20.59 10.02 63 914405 2391 89711588
Adjustment disorder 20.52 10.02 167 914301 9475 89704504
Smear cervix abnormal 20.43 10.02 74 914394 3068 89710911
Klebsiella infection 20.42 10.02 46 914422 10251 89703728
Amenorrhoea 20.41 10.02 56 914412 11666 89702313
Impaired quality of life 20.40 10.02 143 914325 23001 89690978
Hyperprolactinaemia 20.38 10.02 15 914453 5418 89708561
Spinal stenosis 20.38 10.02 267 914201 17157 89696822
Cyanosis 20.35 10.02 114 914354 19341 89694638
Drug tolerance 20.31 10.02 273 914195 17643 89696336
Sleep disorder 20.25 10.02 2289 912179 195741 89518238
Placental disorder 20.23 10.02 48 914420 1563 89712416
Finger deformity 20.12 10.02 454 914014 32443 89681536
Nystagmus 20.11 10.02 26 914442 7201 89706778
Insurance issue 20.11 10.02 51 914417 10907 89703072
Blood glucose decreased 20.05 10.02 146 914322 23283 89690696
Rib deformity 20.04 10.02 19 914449 261 89713718
International normalised ratio increased 20.04 10.02 346 914122 46970 89667009
Limb deformity 19.96 10.02 89 914379 4063 89709916
Skin burning sensation 19.93 10.02 116 914352 19495 89694484
Drug ineffective 19.82 10.02 13236 901232 1371062 88342917
Maternal exposure during delivery 19.82 10.02 7 914461 3839 89710140
Lupus vulgaris 19.73 10.02 595 913873 44464 89669515
Toxic encephalopathy 19.69 10.02 36 914432 8663 89705316
Retinitis 19.68 10.02 518 913950 37940 89676039
Device related infection 19.59 10.02 166 914302 25620 89688359
Atrioventricular block 19.49 10.02 37 914431 8778 89705201
Generalised tonic-clonic seizure 19.39 10.02 242 914226 34661 89679318
Immune-mediated enterocolitis 19.37 10.02 12 914456 4745 89709234
Product administration interrupted 19.36 10.02 63 914405 12429 89701550
Schizophrenia 19.35 10.02 233 914235 14681 89699298
Hallucination, auditory 19.33 10.02 89 914379 15886 89698093
Pruritus genital 19.26 10.02 11 914457 4547 89709432
Pharyngeal swelling 19.26 10.02 45 914423 9899 89704080
Acidosis 19.21 10.02 65 914403 12671 89701308
Sinus congestion 19.20 10.02 386 914082 27038 89686941
Laryngospasm 19.10 10.02 5 914463 3328 89710651
Maternal exposure timing unspecified 19.06 10.02 326 914142 22157 89691822
Onychomadesis 18.98 10.02 603 913865 45395 89668584
Ileus 18.96 10.02 94 914374 16452 89697527
Malignant mediastinal neoplasm 18.83 10.02 43 914425 1365 89712614
Pseudomonal sepsis 18.73 10.02 10 914458 4292 89709687
Anosmia 18.72 10.02 45 914423 9803 89704176
Paranoia 18.71 10.02 67 914401 12841 89701138
Vasoplegia syndrome 18.65 10.02 3 914465 2811 89711168
Acute coronary syndrome 18.57 10.02 52 914416 10761 89703218
Salivary hypersecretion 18.54 10.02 40 914428 9052 89704927
Intracranial pressure increased 18.45 10.02 25 914443 6786 89707193
Type 1 diabetes mellitus 18.43 10.02 13 914455 4799 89709180
Rheumatoid nodule 18.42 10.02 296 914172 19870 89694109
Product dose omission in error 18.41 10.02 126 914342 20377 89693602
Pulmonary alveolar haemorrhage 18.38 10.02 20 914448 5978 89708001
Procedural pain 18.27 10.02 232 914236 33128 89680851
Blood pressure diastolic increased 18.25 10.02 205 914263 12701 89701278
Capillary leak syndrome 18.23 10.02 3 914465 2764 89711215
Systemic candida 18.21 10.02 14 914454 4945 89709034
Visual acuity reduced 18.10 10.02 150 914318 23260 89690719
Hypoglycaemic coma 18.09 10.02 4 914464 2986 89710993
Dysphonia 18.09 10.02 491 913977 62593 89651386
Progressive multifocal leukoencephalopathy 17.90 10.02 89 914379 15566 89698413
Pneumonia viral 17.84 10.02 39 914429 8784 89705195
Device malfunction 17.81 10.02 131 914337 20846 89693133
Catheter site pain 17.77 10.02 18 914450 5561 89708418
Generalised oedema 17.65 10.02 116 914352 18937 89695042
Neuralgia 17.65 10.02 218 914250 31282 89682697
Hereditary angioedema 17.64 10.02 43 914425 9322 89704657
Lacrimation increased 17.64 10.02 181 914287 26881 89687098
Clear cell renal cell carcinoma 17.64 10.02 45 914423 1535 89712444
Lymphoedema 17.62 10.02 75 914393 13678 89700301
Diabetes mellitus 17.56 10.02 509 913959 64366 89649613
Infusion site swelling 17.55 10.02 60 914408 11660 89702319
Leukocytosis 17.54 10.02 214 914254 30776 89683203
Dermatitis acneiform 17.54 10.02 23 914445 6331 89707648
Antinuclear antibody positive 17.53 10.02 156 914312 9085 89704894
Lung disorder 17.50 10.02 1748 912720 148135 89565844
Hypomagnesaemia 17.50 10.02 253 914215 35335 89678644
Hypophagia 17.49 10.02 256 914212 35681 89678298
Shock haemorrhagic 17.46 10.02 64 914404 12181 89701798
Abortion incomplete 17.45 10.02 5 914463 3135 89710844
Epidermal necrosis 17.43 10.02 58 914410 2303 89711676
Multiple sclerosis 17.42 10.02 188 914280 27652 89686327
Pulmonary haemorrhage 17.40 10.02 34 914434 7979 89706000
Epstein-Barr virus associated lymphoproliferative disorder 17.33 10.02 3 914465 2664 89711315
Hyperbilirubinaemia 17.25 10.02 77 914391 13859 89700120
Synovial cyst 17.22 10.02 188 914280 11564 89702415
Potentiating drug interaction 17.22 10.02 19 914449 5643 89708336
Device leakage 17.20 10.02 48 914420 9943 89704036
Infusion site pruritus 17.17 10.02 26 914442 6739 89707240
Hypervolaemia 17.13 10.02 230 914238 32527 89681452
Diplopia 17.13 10.02 196 914272 28518 89685461
Hypokinesia 16.96 10.02 91 914377 15606 89698373
Pain of skin 16.95 10.02 94 914374 15988 89697991
Bundle branch block right 16.91 10.02 18 914450 5435 89708544
Transplant dysfunction 16.87 10.02 17 914451 5265 89708714
Wrist fracture 16.87 10.02 236 914232 15388 89698591
Localised infection 16.87 10.02 451 914017 33111 89680868
Hepatitis acute 16.81 10.02 55 914413 10832 89703147
Pre-eclampsia 16.78 10.02 178 914290 10870 89703109
Dysarthria 16.69 10.02 420 914048 54062 89659917
Respiratory disorder 16.69 10.02 512 913956 64304 89649675
Atrial septal defect 16.66 10.02 141 914327 8093 89705886
Skin exfoliation 16.63 10.02 540 913928 67373 89646606
Post-traumatic stress disorder 16.61 10.02 27 914441 6801 89707178
Pregnancy with contraceptive device 16.53 10.02 16 914452 5050 89708929
Ankylosing spondylitis 16.53 10.02 204 914264 12929 89701050
Ventricular extrasystoles 16.53 10.02 73 914395 13177 89700802
Body mass index abnormal 16.50 10.02 28 914440 711 89713268
Product substitution issue 16.50 10.02 110 914358 17898 89696081
Temperature intolerance 16.42 10.02 64 914404 11966 89702013
Skin plaque 16.38 10.02 49 914419 9926 89704053
Renal disorder 16.30 10.02 276 914192 37583 89676396
Neck mass 16.30 10.02 80 914388 3802 89710177
Complication associated with device 16.26 10.02 122 914346 19327 89694652
Peripheral sensory neuropathy 16.25 10.02 44 914424 9206 89704773
Skin fissures 16.24 10.02 133 914335 20676 89693303
Hypernatraemia 16.23 10.02 45 914423 9342 89704637
Cystitis haemorrhagic 16.22 10.02 19 914449 5494 89708485
Hepatitis B reactivation 16.21 10.02 10 914458 3964 89710015
Coronary artery disease 16.20 10.02 240 914228 33383 89680596
Loss of employment 16.16 10.02 5 914463 2982 89710997
Rheumatoid lung 16.13 10.02 83 914385 4020 89709959
Bone pain 16.11 10.02 489 913979 61494 89652485
Hypotonia 16.11 10.02 60 914408 11366 89702613
Needle issue 16.06 10.02 79 914389 13855 89700124
Cleft lip and palate 16.04 10.02 28 914440 728 89713251
Laryngeal oedema 16.01 10.02 28 914440 6853 89707126
Feeling hot 15.98 10.02 634 913834 77374 89636605
Enthesopathy 15.95 10.02 155 914313 9249 89704730
Anticholinergic syndrome 15.94 10.02 4 914464 2739 89711240
Synovial disorder 15.87 10.02 68 914400 3050 89710929
Bezoar 15.86 10.02 4 914464 2730 89711249
Body height below normal 15.78 10.02 53 914415 2115 89711864
Facial paralysis 15.73 10.02 92 914376 15442 89698537
Pyrexia 15.69 10.02 6214 908254 654271 89059708
Haemodynamic instability 15.68 10.02 63 914405 11676 89702303
Foetal anticonvulsant syndrome 15.58 10.02 26 914442 651 89713328
Ileus paralytic 15.53 10.02 17 914451 5068 89708911
Developmental hip dysplasia 15.52 10.02 43 914425 1542 89712437
Varicella zoster virus infection 15.48 10.02 10 914458 3867 89710112
Blood lactate dehydrogenase increased 15.48 10.02 177 914291 25755 89688224
Long QT syndrome 15.33 10.02 11 914457 4026 89709953
Pulmonary toxicity 15.33 10.02 62 914406 11469 89702510
Cardiac failure acute 15.32 10.02 65 914403 11864 89702115
Disturbance in social behaviour 15.15 10.02 12 914456 4176 89709803
Infective pulmonary exacerbation of cystic fibrosis 15.14 10.02 53 914415 10226 89703753
Nail operation 15.13 10.02 48 914420 1858 89712121
Subdural haematoma 15.09 10.02 102 914366 16543 89697436
Cross sensitivity reaction 15.07 10.02 5 914463 2852 89711127
Hyperuricaemia 15.04 10.02 28 914440 6691 89707288
Treatment noncompliance 14.99 10.02 402 914066 51325 89662654
Pneumatosis intestinalis 14.95 10.02 8 914460 3429 89710550
Head injury 14.89 10.02 223 914245 30965 89683014
Tenosynovitis stenosans 14.88 10.02 79 914389 3874 89710105
Hypertransaminasaemia 14.84 10.02 96 914372 15729 89698250
Incoherent 14.81 10.02 17 914451 4960 89709019
Synovial fluid analysis 14.77 10.02 62 914406 2756 89711223
Total lung capacity increased 14.77 10.02 94 914374 4927 89709052
Reversible cerebral vasoconstriction syndrome 14.73 10.02 12 914456 4118 89709861
Systemic inflammatory response syndrome 14.72 10.02 27 914441 6489 89707490
Loose body in joint 14.70 10.02 39 914429 1363 89712616
Persecutory delusion 14.65 10.02 7 914461 3201 89710778
Hyperlipidaemia 14.64 10.02 154 914314 22762 89691217
Subacute cutaneous lupus erythematosus 14.63 10.02 9 914459 3573 89710406
Hypoalbuminaemia 14.62 10.02 97 914371 15800 89698179
Insomnia 14.59 10.02 3057 911411 330417 89383562
Lung neoplasm 14.52 10.02 117 914351 6618 89707361
Amylase increased 14.51 10.02 31 914437 7041 89706938
Pneumonia bacterial 14.46 10.02 73 914395 12717 89701262
Cardiac disorder 14.46 10.02 450 914018 56422 89657557
Troponin increased 14.35 10.02 77 914391 13204 89700775
Limb reduction defect 14.30 10.02 24 914444 604 89713375
Pneumonia fungal 14.28 10.02 31 914437 7000 89706979
Device use issue 14.26 10.02 10 914458 3703 89710276
Cholelithiasis 14.19 10.02 657 913811 51849 89662130
Serositis 14.18 10.02 37 914431 1280 89712699
Gastroenteritis viral 14.16 10.02 404 914064 29951 89684028
Breast feeding 14.13 10.02 29 914439 854 89713125
Extra dose administered 14.12 10.02 46 914422 9072 89704907
Depression 14.09 10.02 2746 911722 297855 89416124
Hypertelorism 14.03 10.02 22 914446 522 89713457
Congenital arterial malformation 14.00 10.02 17 914451 314 89713665
Malignant melanoma 14.00 10.02 191 914277 12385 89701594
Bacterial infection 14.00 10.02 160 914308 23284 89690695
Skin papilloma 13.93 10.02 101 914367 5529 89708450
Confusional state 13.91 10.02 4230 910238 381975 89332004
Immune effector cell-associated neurotoxicity syndrome 13.85 10.02 23 914445 5745 89708234
Sensitisation 13.84 10.02 13 914455 4162 89709817
Nervous system disorder 13.84 10.02 145 914323 21448 89692531
Erythema of eyelid 13.76 10.02 8 914460 3275 89710704
Intervertebral disc degeneration 13.76 10.02 248 914220 17026 89696953
International normalised ratio fluctuation 13.75 10.02 7 914461 3086 89710893
Hepatic encephalopathy 13.71 10.02 82 914386 13690 89700289
Acute pulmonary oedema 13.71 10.02 50 914418 9530 89704449
Arthritis infective 13.69 10.02 132 914336 7860 89706119
Psychotic symptom 13.68 10.02 3 914465 2253 89711726
Oliguria 13.57 10.02 58 914410 10566 89703413
Eosinophil count increased 13.50 10.02 77 914391 13004 89700975
Product residue present 13.49 10.02 14 914454 4277 89709702
Unevaluable event 13.46 10.02 436 914032 54412 89659567
Impaired gastric emptying 13.43 10.02 75 914393 12734 89701245
Hepatitis cholestatic 13.39 10.02 43 914425 8518 89705461
Bronchopulmonary aspergillosis allergic 13.36 10.02 11 914457 3755 89710224
Metastasis 13.36 10.02 26 914442 6111 89707868
Device deployment issue 13.31 10.02 18 914450 4891 89709088
Immunisation 13.31 10.02 3 914465 2210 89711769
Drug screen positive 13.30 10.02 11 914457 3746 89710233
Stillbirth 13.28 10.02 124 914344 7319 89706660
Acute myocardial infarction 13.25 10.02 260 914208 34630 89679349
Seronegative arthritis 13.22 10.02 258 914210 17976 89696003
Uterine perforation 13.22 10.02 36 914432 7518 89706461
Abdominal pain 13.15 10.02 3674 910794 392047 89321932
Anhedonia 13.07 10.02 65 914403 11366 89702613
Amyloid arthropathy 13.06 10.02 42 914426 1638 89712341
Hypercalciuria 13.05 10.02 18 914450 379 89713600
Tension headache 12.98 10.02 36 914432 7473 89706506
Red blood cell sedimentation rate 12.96 10.02 86 914382 4572 89709407
Skin weeping 12.96 10.02 6 914462 2794 89711185
Immune thrombocytopenia 12.92 10.02 80 914388 13246 89700733
Blood test abnormal 12.90 10.02 142 914326 20810 89693169
Rales 12.89 10.02 100 914368 15727 89698252
Endophthalmitis 12.89 10.02 17 914451 4668 89709311
Choking 12.87 10.02 70 914398 11963 89702016
Antibody test positive 12.84 10.02 62 914406 2927 89711052
Device physical property issue 12.77 10.02 6 914462 2770 89711209
Labyrinthitis 12.74 10.02 58 914410 2671 89711308
Feeding disorder 12.74 10.02 114 914354 17398 89696581
Lupus nephritis 12.72 10.02 88 914380 4744 89709235
Polyuria 12.71 10.02 55 914413 9985 89703994
Nocardiosis 12.70 10.02 5 914463 2565 89711414
Metastases to skin 12.67 10.02 3 914465 2137 89711842
Hypogammaglobulinaemia 12.60 10.02 60 914408 10614 89703365
Immune-mediated hepatitis 12.59 10.02 7 914461 2937 89711042
Gene mutation 12.59 10.02 3 914465 2127 89711852
Blepharospasm 12.54 10.02 682 913786 54763 89659216
Ear infection 12.54 10.02 841 913627 68934 89645045
Septic shock 12.46 10.02 708 913760 83452 89630527
Bone density increased 12.42 10.02 28 914440 881 89713098
Human antichimeric antibody positive 12.42 10.02 43 914425 1743 89712236
Cold sweat 12.41 10.02 87 914381 13994 89699985
Trigeminal neuralgia 12.41 10.02 14 914454 4117 89709862
Atrioventricular block second degree 12.41 10.02 16 914452 4436 89709543
Ankle arthroplasty 12.36 10.02 59 914409 2772 89711207
Gastroschisis 12.34 10.02 18 914450 400 89713579
Mouth ulceration 12.31 10.02 507 913961 39467 89674512
Respiratory tract infection 12.26 10.02 721 913747 58357 89655622
Hepatitis fulminant 12.26 10.02 13 914455 3932 89710047
Postoperative wound infection 12.24 10.02 197 914271 13229 89700750
Cardiac failure chronic 12.22 10.02 24 914444 5622 89708357
Pneumothorax 12.16 10.02 129 914339 19038 89694941
Breast cancer metastatic 12.14 10.02 96 914372 15036 89698943
Haemoglobin decreased 12.12 10.02 1837 912631 160119 89553860
Retrognathia 12.11 10.02 21 914447 543 89713436
Cutaneous vasculitis 12.05 10.02 35 914433 7158 89706821
Cell death 12.04 10.02 8 914460 3047 89710932
Breast cancer stage I 12.02 10.02 53 914415 9571 89704408
Brain injury 12.01 10.02 39 914429 7699 89706280
Personality change 12.00 10.02 36 914432 7285 89706694
Femoral hernia incarcerated 12.00 10.02 38 914430 1470 89712509
Product monitoring error 11.98 10.02 17 914451 4527 89709452
Exomphalos 11.98 10.02 21 914447 548 89713431
Hallucinations, mixed 11.93 10.02 26 914442 5863 89708116
Colorectal cancer 11.91 10.02 13 914455 3880 89710099
Depressive symptom 11.85 10.02 22 914446 5263 89708716
Pancreatic steatosis 11.82 10.02 40 914428 1602 89712377
Lymphatic fistula 11.79 10.02 37 914431 1424 89712555
Noninfective gingivitis 11.78 10.02 48 914420 2105 89711874
Gangrene 11.76 10.02 189 914279 12687 89701292
Speech disorder developmental 11.74 10.02 28 914440 915 89713064
Nail disorder 11.72 10.02 718 913750 58349 89655630
Product availability issue 11.71 10.02 37 914431 7367 89706612
Pemphigoid 11.70 10.02 49 914419 8977 89705002
Hypoparathyroidism 11.69 10.02 29 914439 972 89713007
Cerebrovascular accident 11.66 10.02 1080 913388 122453 89591526
Asthma-chronic obstructive pulmonary disease overlap syndrome 11.61 10.02 87 914381 4812 89709167
Injection site pain 11.61 10.02 1555 912913 172144 89541835
Formication 11.60 10.02 19 914449 4772 89709207
Tenosynovitis 11.56 10.02 209 914259 14358 89699621
Rhinovirus infection 11.53 10.02 27 914441 5936 89708043
Scleritis 11.52 10.02 91 914377 5117 89708862
Type I hypersensitivity 11.51 10.02 15 914453 4140 89709839
Congestive cardiomyopathy 11.46 10.02 37 914431 7317 89706662
Nail injury 11.38 10.02 25 914443 773 89713206
Metabolic disorder 11.35 10.02 38 914430 7432 89706547
Pancreatitis 11.35 10.02 582 913886 69244 89644735
Breast cancer in situ 11.33 10.02 41 914427 1699 89712280
Blood potassium decreased 11.33 10.02 381 914087 47346 89666633
Prescribed overdose 11.31 10.02 1138 913330 96487 89617492
Blood prolactin increased 11.29 10.02 12 914456 3625 89710354
Cholangitis 11.28 10.02 36 914432 7146 89706833
Cushingoid 11.22 10.02 157 914311 10238 89703741
Sedation complication 11.18 10.02 113 914355 16831 89697148
Blood lactic acid increased 11.17 10.02 48 914420 8730 89705249
Incorrect product administration duration 11.10 10.02 133 914335 19189 89694790
Activated partial thromboplastin time prolonged 11.09 10.02 41 914427 7784 89706195
Incorrect dose administered by device 11.08 10.02 26 914442 5711 89708268
Calciphylaxis 11.06 10.02 65 914403 3311 89710668
Dysphoria 11.02 10.02 29 914439 6125 89707854
Cardiac dysfunction 11.01 10.02 12 914456 3585 89710394
Wound infection pseudomonas 10.99 10.02 45 914423 1978 89712001
Neoplasm recurrence 10.98 10.02 10 914458 3249 89710730
Blood iron increased 10.98 10.02 44 914424 1915 89712064
Wrong product administered 10.97 10.02 40 914428 7625 89706354
Infection reactivation 10.95 10.02 3 914465 1937 89712042
Stress fracture 10.94 10.02 134 914334 8477 89705502
Breast cancer stage II 10.85 10.02 448 914020 34886 89679093
Liver disorder 10.84 10.02 1390 913078 119879 89594100
Wrong technique in device usage process 10.83 10.02 27 914441 5808 89708171
Salivary gland operation 10.82 10.02 3 914465 0 89713979
Ingrown hair 10.81 10.02 21 914447 594 89713385
Eyelid oedema 10.80 10.02 70 914398 11464 89702515
Dermatitis exfoliative 10.76 10.02 25 914443 5511 89708468
Pharyngeal oedema 10.76 10.02 88 914380 13683 89700296
Product quality issue 10.74 10.02 673 913795 78652 89635327
Bundle branch block left 10.73 10.02 42 914426 7843 89706136
Tendonitis 10.69 10.02 287 914181 21085 89692894
Gonorrhoea 10.68 10.02 10 914458 135 89713844
Drug abuser 10.66 10.02 7 914461 2683 89711296
Decreased appetite 10.65 10.02 3519 910949 373021 89340958
Polycystic ovaries 10.62 10.02 26 914442 5628 89708351
Therapeutic response unexpected 10.60 10.02 156 914312 21724 89692255
Ventricular arrhythmia 10.59 10.02 17 914451 4304 89709675
Bone disorder 10.59 10.02 307 914161 22813 89691166
Candida infection 10.58 10.02 262 914206 33795 89680184
Nervousness 10.58 10.02 262 914206 33794 89680185
Device loosening 10.56 10.02 26 914442 867 89713112
Shunt malfunction 10.56 10.02 8 914460 79 89713900
Hyperthyroidism 10.53 10.02 126 914342 18184 89695795
Twin pregnancy 10.52 10.02 32 914436 1211 89712768
Hyperpyrexia 10.51 10.02 20 914448 4741 89709238
Creatinine renal clearance decreased 10.51 10.02 131 914337 18768 89695211
Hyperammonaemia 10.49 10.02 32 914436 6443 89707536
Disorganised speech 10.48 10.02 3 914465 1882 89712097
Ventricular hypokinesia 10.48 10.02 24 914444 5317 89708662
Poor quality device used 10.48 10.02 5 914463 2288 89711691
Bacteraemia 10.46 10.02 160 914308 22140 89691839
Aplasia 10.46 10.02 15 914453 3976 89710003
Short stature 10.45 10.02 29 914439 1041 89712938
Catheter site erythema 10.43 10.02 21 914447 4873 89709106
Acute graft versus host disease in intestine 10.38 10.02 4 914464 2079 89711900
Blood potassium increased 10.38 10.02 147 914321 20602 89693377
Intentional dose omission 10.37 10.02 122 914346 17661 89696318
Heparin-induced thrombocytopenia 10.32 10.02 24 914444 5288 89708691
Blood parathyroid hormone decreased 10.31 10.02 177 914291 12039 89701940
Terminal state 10.29 10.02 8 914460 2810 89711169
Night sweats 10.28 10.02 1466 913002 127300 89586679
Injection site haematoma 10.27 10.02 111 914357 6811 89707168
Brain abscess 10.25 10.02 8 914460 2804 89711175
Central nervous system lesion 10.24 10.02 72 914396 11574 89702405
Hunger 10.24 10.02 33 914435 6530 89707449
Hypoventilation 10.23 10.02 24 914444 5272 89708707
Thirst 10.21 10.02 110 914358 16185 89697794
Acute myeloid leukaemia recurrent 10.17 10.02 4 914464 2053 89711926
Intraocular pressure increased 10.16 10.02 37 914431 7056 89706923
Enterocolitis 10.16 10.02 63 914405 10427 89703552
Burning sensation 10.10 10.02 530 913938 62922 89651057
Implant site pain 10.08 10.02 7 914461 2605 89711374
Presyncope 10.06 10.02 244 914224 31561 89682418
Haematemesis 10.06 10.02 261 914207 33465 89680514
Deafness transitory 10.06 10.02 4 914464 2039 89711940
Cervical incompetence 10.04 10.02 21 914447 627 89713352
Clostridium test positive 10.02 10.02 25 914443 5376 89708603

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Rheumatoid arthritis 513.27 10.28 952 272294 41488 42306601
Drug abuse 457.91 10.28 64 273182 104707 42243382
Toxicity to various agents 409.59 10.28 521 272725 228615 42119474
Completed suicide 345.98 10.28 95 273151 96370 42251719
Milk-alkali syndrome 324.36 10.28 134 273112 573 42347516
Foetal exposure during pregnancy 251.07 10.28 770 272476 46541 42301548
Psoriatic arthropathy 204.11 10.28 477 272769 24490 42323599
Arthralgia 192.14 10.28 2086 271160 203152 42144937
Drug interaction 182.27 10.28 987 272259 266012 42082077
Off label use 167.49 10.28 2986 270260 635349 41712740
Intentional overdose 161.06 10.28 64 273182 51392 42296697
Product use in unapproved indication 150.16 10.28 640 272606 183816 42164273
Drug ineffective 146.16 10.28 3010 270236 627187 41720902
Sickle cell anaemia with crisis 124.10 10.28 155 273091 4735 42343354
Dysmorphism 117.72 10.28 125 273121 3191 42344898
Psoriasis 108.18 10.28 605 272641 47999 42300090
Joint swelling 107.51 10.28 776 272470 67246 42280843
Coma 103.75 10.28 114 273132 53440 42294649
Death 95.57 10.28 2297 270949 468888 41879201
Disease progression 94.03 10.28 538 272708 143118 42204971
Suicide attempt 92.80 10.28 95 273151 46005 42302084
Hepatic function abnormal 92.15 10.28 117 273129 51450 42296639
Drug resistance 91.28 10.28 53 273193 34195 42313894
Blood pressure fluctuation 87.22 10.28 373 272873 26535 42321554
Shunt stenosis 84.49 10.28 56 273190 721 42347368
Pulmonary fibrosis 83.53 10.28 366 272880 26315 42321774
Musculoskeletal stiffness 80.59 10.28 640 272606 57125 42290964
Arthritis 80.33 10.28 503 272743 41562 42306527
Respiratory symptom 78.83 10.28 201 273045 10905 42337184
Sedation 77.27 10.28 50 273196 30425 42317664
Blood pressure systolic increased 76.68 10.28 369 272877 27599 42320490
Enthesopathy 74.93 10.28 121 273125 4707 42343382
Drug dependence 74.77 10.28 47 273199 29047 42319042
Serotonin syndrome 74.77 10.28 36 273210 25809 42322280
Overdose 74.49 10.28 384 272862 104880 42243209
Hypercalcaemia 73.61 10.28 269 272977 17789 42330300
Pain in extremity 73.43 10.28 1365 271881 149239 42198850
Drug ineffective for unapproved indication 72.31 10.28 115 273131 46048 42302041
Small for dates baby 71.15 10.28 124 273122 5139 42342950
Premature baby 70.50 10.28 315 272931 22838 42325251
Synovitis 70.43 10.28 240 273006 15327 42332762
Pulmonary vasculitis 70.04 10.28 136 273110 6130 42341959
Intentional product misuse 69.97 10.28 186 273060 61714 42286375
Pain 67.65 10.28 2051 271195 242797 42105292
Blood pressure systolic abnormal 66.76 10.28 124 273122 5404 42342685
Nodule 66.44 10.28 204 273042 12330 42335759
Exposure during pregnancy 66.26 10.28 160 273086 8388 42339701
Tenosynovitis 63.97 10.28 111 273135 4584 42343505
Arthropathy 63.59 10.28 365 272881 29232 42318857
Nasopharyngitis 61.38 10.28 815 272431 83181 42264908
Neuritis 61.17 10.28 128 273118 6092 42341997
Speech disorder developmental 60.51 10.28 74 273172 2211 42345878
Blood pressure diastolic abnormal 60.14 10.28 126 273120 6002 42342087
Angioedema 58.23 10.28 115 273131 42362 42305727
Shunt occlusion 57.96 10.28 50 273196 977 42347112
Loss of personal independence in daily activities 56.40 10.28 527 272719 49289 42298800
Febrile neutropenia 56.07 10.28 845 272401 184858 42163231
Poisoning 55.50 10.28 13 273233 14686 42333403
Myelosuppression 55.07 10.28 110 273136 40351 42307738
C-reactive protein abnormal 55.06 10.28 157 273089 9104 42338985
Suicidal ideation 54.97 10.28 144 273102 48017 42300072
Maternal exposure during pregnancy 54.50 10.28 131 273115 6847 42341242
Multiple organ dysfunction syndrome 53.91 10.28 382 272864 96653 42251436
Foetal anticonvulsant syndrome 53.09 10.28 51 273195 1151 42346938
Neonatal respiratory distress syndrome 52.96 10.28 100 273146 4413 42343676
Hypoglycaemia neonatal 52.73 10.28 67 273179 2083 42346006
Rhabdomyolysis 52.19 10.28 290 272956 77729 42270360
Neuroleptic malignant syndrome 52.06 10.28 37 273209 21435 42326654
Eosinophilic granulomatosis with polyangiitis 50.93 10.28 146 273100 8492 42339597
Lactic acidosis 49.65 10.28 138 273108 45123 42302966
Altered state of consciousness 48.61 10.28 70 273176 29189 42318900
Drug reaction with eosinophilia and systemic symptoms 47.11 10.28 127 273119 41948 42306141
Heart rate decreased 46.77 10.28 397 272849 36135 42311954
Drug use disorder 45.84 10.28 6 273240 10327 42337762
Depressed level of consciousness 45.70 10.28 156 273090 47814 42300275
Low birth weight baby 45.49 10.28 154 273092 9801 42338288
Antineutrophil cytoplasmic antibody positive 45.49 10.28 92 273154 4273 42343816
Palmar-plantar erythrodysaesthesia syndrome 45.43 10.28 39 273207 20543 42327546
Acute kidney injury 45.34 10.28 1910 271336 365427 41982662
Blood pressure diastolic decreased 45.23 10.28 158 273088 10217 42337872
Grip strength decreased 43.98 10.28 81 273165 3507 42344582
Plantar fasciitis 43.69 10.28 74 273172 2996 42345093
Osteoarthritis 43.61 10.28 287 272959 24118 42323971
Pathogen resistance 43.48 10.28 10 273236 11440 42336649
Alanine aminotransferase abnormal 43.20 10.28 97 273149 4847 42343242
Learning disorder 43.18 10.28 44 273202 1069 42347020
Tongue disorder 43.06 10.28 102 273144 5281 42342808
Mite allergy 42.98 10.28 98 273148 4948 42343141
Jaundice neonatal 42.89 10.28 61 273185 2118 42345971
Malignant neoplasm progression 42.81 10.28 466 272780 107934 42240155
Respiratory arrest 42.47 10.28 73 273173 28351 42319738
Hypospadias 41.81 10.28 79 273167 3488 42344601
Blood pressure diastolic increased 41.45 10.28 112 273134 6293 42341796
Weight decreased 41.40 10.28 1678 271568 206270 42141819
Respiratory depression 41.35 10.28 36 273210 18832 42329257
Maternal drugs affecting foetus 41.30 10.28 82 273164 3757 42344332
Obstructive airways disorder 41.15 10.28 286 272960 24473 42323616
Atrial septal defect 41.15 10.28 128 273118 7791 42340298
Haemoglobin decreased 41.00 10.28 1126 272120 131345 42216744
Toxic epidermal necrolysis 40.61 10.28 68 273178 26682 42321407
Mycotic allergy 40.56 10.28 94 273152 4797 42343292
Sopor 40.36 10.28 17 273229 13185 42334904
Bradycardia 40.27 10.28 352 272894 85132 42262957
Cryptorchism 40.27 10.28 57 273189 1970 42346119
Blood parathyroid hormone decreased 39.98 10.28 51 273195 1592 42346497
Autism spectrum disorder 39.87 10.28 70 273176 2918 42345171
Cytomegalovirus infection 39.68 10.28 93 273153 32213 42315876
Spirometry abnormal 39.54 10.28 96 273150 5050 42343039
Colitis ulcerative 39.26 10.28 295 272951 25880 42322209
Psychotic disorder 39.24 10.28 80 273166 29128 42318961
Venoocclusive liver disease 39.11 10.28 9 273237 10293 42337796
Lower respiratory tract infection 38.49 10.28 419 272827 40787 42307302
Dust allergy 38.36 10.28 97 273149 5235 42342854
Agitation 38.29 10.28 248 272998 64066 42284023
Substance abuse 37.58 10.28 6 273240 8899 42339190
Neurological symptom 37.53 10.28 145 273101 9846 42338243
Wrong technique in product usage process 37.08 10.28 144 273102 42491 42305598
Exposure via breast milk 36.98 10.28 61 273185 2416 42345673
Cytomegalovirus infection reactivation 36.48 10.28 13 273233 11165 42336924
Immune reconstitution inflammatory syndrome 36.31 10.28 10 273236 10133 42337956
Fractional exhaled nitric oxide increased 36.12 10.28 48 273198 1561 42346528
Joint effusion 36.06 10.28 101 273145 5796 42342293
Arteriosclerosis coronary artery 36.06 10.28 224 273022 18453 42329636
Rheumatoid nodule 35.94 10.28 67 273179 2928 42345161
Maternal exposure during breast feeding 35.85 10.28 47 273199 1508 42346581
Intentional self-injury 35.81 10.28 27 273219 15175 42332914
Total lung capacity abnormal 35.33 10.28 84 273162 4359 42343730
Acute hepatic failure 34.56 10.28 35 273211 17038 42331051
Syndactyly 34.41 10.28 36 273210 903 42347186
Peripheral swelling 34.35 10.28 789 272457 89481 42258608
Shock 34.05 10.28 86 273160 29035 42319054
Exostosis 34.00 10.28 96 273150 5535 42342554
Conjunctivitis allergic 33.97 10.28 99 273147 5812 42342277
Aggression 33.58 10.28 157 273089 44006 42304083
Drug withdrawal syndrome 33.44 10.28 54 273192 21495 42326594
Hand deformity 33.00 10.28 74 273172 3694 42344395
Abdominal discomfort 32.87 10.28 671 272575 74584 42273505
Blood pressure increased 32.84 10.28 871 272375 101057 42247032
BK virus infection 32.71 10.28 8 273238 8776 42339313
Ventricular septal defect 32.67 10.28 81 273165 4318 42343771
Post transplant lymphoproliferative disorder 32.63 10.28 9 273237 9111 42338978
Hyperparathyroidism secondary 32.54 10.28 49 273197 1793 42346296
Chronic sinusitis 32.42 10.28 69 273177 3323 42344766
Pancytopenia 32.08 10.28 985 272261 116758 42231331
Mucormycosis 32.05 10.28 4 273242 7139 42340950
Anaphylactic shock 31.94 10.28 64 273182 23453 42324636
Nasal polyps 31.92 10.28 74 273172 3777 42344312
Wound 31.62 10.28 203 273043 16914 42331175
Joint laxity 30.89 10.28 24 273222 402 42347687
Cardiac arrest 30.42 10.28 505 272741 108815 42239274
Foot deformity 30.21 10.28 86 273160 4982 42343107
Pruritus 30.11 10.28 951 272295 187820 42160269
Central nervous system mass 30.07 10.28 32 273214 819 42347270
Wall motion score index abnormal 29.94 10.28 32 273214 823 42347266
Cardiac failure 29.93 10.28 493 272753 106363 42241726
Developmental delay 29.58 10.28 64 273182 3118 42344971
Calciphylaxis 29.48 10.28 37 273209 1136 42346953
Haematocrit decreased 29.46 10.28 348 272898 34560 42313529
Therapy partial responder 29.38 10.28 52 273194 19969 42328120
Basal cell carcinoma 29.07 10.28 247 272999 22486 42325603
Cardiac murmur 29.06 10.28 160 273086 12615 42335474
Suspected suicide 28.99 10.28 3 273243 6196 42341893
Respiratory failure 28.81 10.28 614 272632 127518 42220571
Maternal exposure before pregnancy 28.72 10.28 35 273211 1042 42347047
Airway remodelling 28.59 10.28 32 273214 868 42347221
Cardiac septal defect 28.57 10.28 33 273213 927 42347162
Inflammation 28.37 10.28 337 272909 33510 42314579
Renal impairment 28.16 10.28 517 272729 109711 42238378
Akathisia 28.09 10.28 16 273230 10435 42337654
Acute graft versus host disease 27.77 10.28 9 273237 8206 42339883
Arteriosclerosis 27.69 10.28 204 273042 17785 42330304
Normochromic normocytic anaemia 27.59 10.28 123 273123 8908 42339181
Plagiocephaly 27.46 10.28 26 273220 576 42347513
Delirium 27.12 10.28 211 273035 52308 42295781
Polyarthritis 26.98 10.28 83 273163 5021 42343068
Bradycardia neonatal 26.92 10.28 38 273208 1310 42346779
Granulomatous pneumonitis 26.89 10.28 10 273236 30 42348059
Red blood cell sedimentation rate increased 26.52 10.28 130 273116 9794 42338295
Atopy 26.51 10.28 32 273214 943 42347146
Syringe issue 26.18 10.28 11 273235 8545 42339544
Device leakage 25.90 10.28 17 273229 10268 42337821
Cytokine release syndrome 25.84 10.28 173 273073 44354 42303735
Acute chest syndrome 25.82 10.28 33 273213 1032 42347057
Hungry bone syndrome 25.82 10.28 16 273230 182 42347907
Skin cancer 25.70 10.28 143 273103 11319 42336770
Knee arthroplasty 25.63 10.28 118 273128 8663 42339426
Joint range of motion decreased 25.52 10.28 108 273138 7645 42340444
Nasal disorder 25.44 10.28 46 273200 1963 42346126
Finger deformity 25.40 10.28 41 273205 1594 42346495
Hypermobility syndrome 25.35 10.28 20 273226 343 42347746
Acute graft versus host disease in skin 25.33 10.28 8 273238 7416 42340673
Aspergillus infection 25.22 10.28 39 273207 15798 42332291
Somnolence 25.19 10.28 700 272546 140405 42207684
Anal fistula 24.85 10.28 92 273154 6121 42341968
Dysgraphia 24.83 10.28 52 273194 2476 42345613
Respiratory disorder neonatal 24.81 10.28 45 273201 1925 42346164
Accidental exposure to product 24.81 10.28 59 273187 20334 42327755
Vitamin D deficiency 24.70 10.28 110 273136 7963 42340126
Mucocutaneous ulceration 24.64 10.28 23 273223 500 42347589
Tachycardia 24.63 10.28 478 272768 100609 42247480
Foetal growth restriction 24.38 10.28 82 273164 5201 42342888
Crohn's disease 24.36 10.28 57 273189 2927 42345162
Talipes 24.35 10.28 48 273198 2188 42345901
Body temperature decreased 24.25 10.28 167 273079 14246 42333843
Infusion related reaction 24.23 10.28 535 272711 60271 42287818
Anal fissure 23.90 10.28 81 273165 5158 42342931
Caesarean section 23.89 10.28 46 273200 2060 42346029
Congenital hand malformation 23.83 10.28 25 273221 629 42347460
Hyperglycaemia 23.79 10.28 184 273062 45675 42302414
Agranulocytosis 23.76 10.28 108 273138 30504 42317585
Hepatic failure 23.66 10.28 145 273101 37955 42310134
C-reactive protein increased 23.39 10.28 553 272693 63007 42285082
Cystitis haemorrhagic 23.12 10.28 9 273237 7320 42340769
Drug withdrawal syndrome neonatal 23.08 10.28 72 273174 4389 42343700
Large for dates baby 22.84 10.28 29 273217 901 42347188
Metabolic alkalosis 22.75 10.28 45 273201 2056 42346033
Adenovirus infection 22.08 10.28 8 273238 6801 42341288
Frequent bowel movements 22.02 10.28 222 273024 21185 42326904
Withdrawal syndrome 22.02 10.28 38 273208 14737 42333352
Exposure to toxic agent 21.97 10.28 3 273243 5001 42343088
Posterior reversible encephalopathy syndrome 21.96 10.28 30 273216 12791 42335298
Pneumonia aspiration 21.93 10.28 210 273036 49868 42298221
Microangiopathy 21.92 10.28 39 273207 1643 42346446
Sexual dysfunction 21.90 10.28 8 273238 6767 42341322
Blood creatine phosphokinase increased 21.90 10.28 201 273045 48137 42299952
Tendonitis 21.89 10.28 123 273123 9771 42338318
Knee deformity 21.89 10.28 26 273220 753 42347336
Serum ferritin increased 21.81 10.28 98 273148 7121 42340968
Rebound effect 21.77 10.28 10 273236 7369 42340720
Obsessive-compulsive disorder 21.74 10.28 8 273238 6735 42341354
Haematotoxicity 21.69 10.28 23 273223 10962 42337127
Pneumonia 21.53 10.28 3053 270193 419096 41928993
Ultrasound antenatal screen 21.34 10.28 22 273224 542 42347547
Cytomegalovirus viraemia 21.32 10.28 21 273225 10356 42337733
Localised infection 21.31 10.28 212 273034 20161 42327928
Trisomy 18 21.28 10.28 27 273219 838 42347251
Neurotoxicity 21.13 10.28 79 273167 23572 42324517
Polyomavirus-associated nephropathy 21.13 10.28 5 273241 5610 42342479
Agitation neonatal 21.09 10.28 35 273211 1393 42346696
Haematochezia 21.07 10.28 507 272739 57929 42290160
Vasculitis 21.01 10.28 195 273051 18199 42329890
Arthritis infective 20.99 10.28 66 273180 4040 42344049
Catarrh 20.97 10.28 85 273161 5901 42342188
Poor venous access 20.83 10.28 97 273149 7155 42340934
Eosinophilic myocarditis 20.75 10.28 34 273212 1339 42346750
Drug dose omission by device 20.70 10.28 6 273240 5880 42342209
Graft versus host disease in gastrointestinal tract 20.54 10.28 4 273242 5139 42342950
Diaphragmatic disorder 20.53 10.28 32 273214 1207 42346882
Neoplasm progression 20.37 10.28 106 273140 28894 42319195
Hydrops foetalis 20.32 10.28 27 273219 878 42347211
Respiratory rate increased 20.32 10.28 131 273115 10931 42337158
Urticaria 20.26 10.28 343 272903 73693 42274396
Multiple-drug resistance 19.98 10.28 11 273235 7311 42340778
Language disorder 19.91 10.28 47 273199 2428 42345661
Wheezing 19.66 10.28 475 272771 54306 42293783
Foetal disorder 19.48 10.28 29 273217 1050 42347039
Fatigue 19.44 10.28 3127 270119 432514 41915575
Squamous cell carcinoma of lung 19.42 10.28 44 273202 2212 42345877
Selective eating disorder 19.37 10.28 38 273208 1726 42346363
Hallucination 19.33 10.28 256 272990 57251 42290838
Dermatitis atopic 19.32 10.28 31 273215 12373 42335716
Renal failure 19.23 10.28 740 272506 142986 42205103
Diffuse large B-cell lymphoma recurrent 19.09 10.28 4 273242 4882 42343207
Accident at work 19.06 10.28 27 273219 934 42347155
Arthrodesis 19.05 10.28 21 273225 560 42347529
Dyspraxia 18.90 10.28 19 273227 454 42347635
Hypoglycaemia 18.84 10.28 270 272976 59584 42288505
Astigmatism 18.83 10.28 32 273214 1299 42346790
Motor developmental delay 18.79 10.28 23 273223 688 42347401
Osteomyelitis 18.76 10.28 189 273057 18034 42330055
Upper respiratory tract infection 18.73 10.28 377 272869 41796 42306293
Ankyloglossia congenital 18.54 10.28 17 273229 361 42347728
Oropharyngeal pain 18.54 10.28 379 272867 42131 42305958
Aplasia pure red cell 18.53 10.28 93 273153 7073 42341016
Sensation of foreign body 18.40 10.28 58 273188 3555 42344534
Hyperbilirubinaemia neonatal 18.22 10.28 25 273221 839 42347250
Blood parathyroid hormone increased 18.19 10.28 39 273207 1888 42346201
Calcinosis 18.15 10.28 25 273221 842 42347247
Asphyxia 18.10 10.28 16 273230 8310 42339779
Extrapyramidal disorder 18.02 10.28 50 273196 16362 42331727
Joint stiffness 17.99 10.28 138 273108 12184 42335905
Miosis 17.91 10.28 37 273209 13409 42334680
Proteinuria 17.89 10.28 81 273165 22902 42325187
Burns second degree 17.85 10.28 82 273164 6014 42342075
Ankylosing spondylitis 17.85 10.28 91 273155 6965 42341124
Cardiogenic shock 17.56 10.28 145 273101 35495 42312594
Full blood count abnormal 17.49 10.28 279 272967 29597 42318492
Red blood cell count decreased 17.49 10.28 301 272945 32414 42315675
Psychiatric decompensation 17.47 10.28 3 273243 4219 42343870
Thymus disorder 17.32 10.28 14 273232 249 42347840
Radiation inflammation 17.28 10.28 27 273219 1021 42347068
Umbilical hernia 17.25 10.28 75 273171 5372 42342717
Nephropathy toxic 17.25 10.28 53 273193 16785 42331304
Dyslexia 16.99 10.28 16 273230 352 42347737
Systemic lupus erythematosus 16.87 10.28 110 273136 9214 42338875
Ear disorder 16.84 10.28 39 273207 1989 42346100
Cleft lip and palate 16.76 10.28 25 273221 907 42347182
Hypotension 16.71 10.28 1423 271823 256208 42091881
Congenital anomaly 16.68 10.28 33 273213 1508 42346581
Temperature regulation disorder 16.58 10.28 28 273218 1131 42346958
Chronic graft versus host disease 16.52 10.28 9 273237 6016 42342073
Musculoskeletal pain 16.49 10.28 303 272943 33037 42315052
Mobility decreased 16.48 10.28 318 272928 34988 42313101
Acute respiratory distress syndrome 16.47 10.28 119 273127 29989 42318100
Mean cell volume increased 16.46 10.28 59 273187 3864 42344225
Cellulitis 16.44 10.28 514 272732 61071 42287018
Congenital foot malformation 16.39 10.28 17 273229 422 42347667
Dystonia 16.37 10.28 36 273210 12754 42335335
Anti-erythropoietin antibody positive 16.35 10.28 24 273222 858 42347231
Hypotonia neonatal 16.33 10.28 32 273214 1452 42346637
Brain oedema 16.30 10.28 52 273194 16275 42331814
Metabolic acidosis 16.30 10.28 234 273012 51624 42296465
Loss of consciousness 16.26 10.28 459 272787 91895 42256194
Exposure via skin contact 16.20 10.28 6 273240 5032 42343057
Euglycaemic diabetic ketoacidosis 16.19 10.28 8 273238 5652 42342437
Diverticulum 16.19 10.28 93 273153 7448 42340641
Femur fracture 16.10 10.28 113 273133 9699 42338390
Transient aphasia 16.06 10.28 20 273226 609 42347480
Kyphosis 16.04 10.28 30 273216 1314 42346775
Gingival pain 15.85 10.28 101 273145 8393 42339696
Lower respiratory tract congestion 15.82 10.28 33 273213 1567 42346522
Product quality issue 15.80 10.28 60 273186 17822 42330267
Hallucination, auditory 15.80 10.28 46 273200 14818 42333271
Back disorder 15.70 10.28 92 273154 7422 42340667
Disinhibition 15.61 10.28 3 273243 3892 42344197
Cholelithiasis 15.60 10.28 223 273023 23123 42324966
Electrocardiogram QT prolonged 15.54 10.28 215 273031 47730 42300359
Fall 15.52 10.28 1724 271522 232796 42115293
Unresponsive to stimuli 15.37 10.28 128 273118 31275 42316814
Blood test abnormal 15.34 10.28 138 273108 12768 42335321
Peritonitis bacterial 15.32 10.28 86 273160 6829 42341260
Influenza 15.32 10.28 514 272732 61661 42286428
Hepatic encephalopathy 15.30 10.28 54 273192 16388 42331701
Rash maculo-papular 15.28 10.28 160 273086 37343 42310746
Tuberculosis 15.24 10.28 114 273132 9985 42338104
Anaphylactic reaction 15.21 10.28 188 273058 42555 42305534
Paranoia 15.20 10.28 43 273203 13983 42334106
Spina bifida 15.08 10.28 16 273230 408 42347681
Stevens-Johnson syndrome 15.06 10.28 82 273164 22096 42325993
Blood albumin decreased 15.02 10.28 158 273088 15244 42332845
Open reduction of fracture 15.01 10.28 9 273237 96 42347993
Mania 14.93 10.28 28 273218 10519 42337570
Pulmonary alveolar haemorrhage 14.93 10.28 153 273093 14663 42333426
Lung neoplasm malignant 14.90 10.28 188 273058 18959 42329130
Plasma cell myeloma 14.86 10.28 405 272841 47173 42300916
Intellectual disability 14.86 10.28 36 273210 1891 42346198
Diverticular perforation 14.84 10.28 55 273191 3661 42344428
Fistula discharge 14.84 10.28 26 273220 1082 42347007
Pyrexia 14.79 10.28 2259 270987 391783 41956306
Hypophosphatasia 14.77 10.28 7 273239 44 42348045
Joint ankylosis 14.76 10.28 33 273213 1644 42346445
Haemodynamic instability 14.74 10.28 37 273209 12520 42335569
Oxygen saturation decreased 14.74 10.28 530 272716 64157 42283932
Malignant melanoma 14.70 10.28 107 273139 9293 42338796
Medical device implantation 14.68 10.28 19 273227 602 42347487
Cleft lip 14.64 10.28 14 273232 314 42347775
Multiple congenital abnormalities 14.61 10.28 18 273228 542 42347547
Hypokalaemia 14.60 10.28 349 272897 71372 42276717
Colorectal cancer 14.60 10.28 7 273239 5031 42343058
Limb reduction defect 14.50 10.28 14 273232 318 42347771
Vomiting 14.49 10.28 1631 271615 288092 42059997
Congenital bladder anomaly 14.45 10.28 13 273233 269 42347820
Heart rate irregular 14.43 10.28 162 273084 15888 42332201
Lacrimal disorder 14.43 10.28 14 273232 320 42347769
Cerebral haemorrhage 14.39 10.28 170 273076 38796 42309293
Spinal disorder 14.38 10.28 63 273183 4528 42343561
Transfusion-related circulatory overload 14.36 10.28 21 273225 748 42347341
Myoglobin blood increased 14.29 10.28 54 273192 3628 42344461
Otitis media 14.28 10.28 54 273192 3629 42344460
Weight decrease neonatal 14.18 10.28 14 273232 327 42347762
Virologic failure 14.18 10.28 4 273242 3990 42344099
Pectus excavatum 14.10 10.28 12 273234 230 42347859
Renal aplasia 14.07 10.28 21 273225 762 42347327
Disseminated intravascular coagulation 14.05 10.28 97 273149 24697 42323392
Sinusitis 14.05 10.28 400 272846 46892 42301197
Red blood cell sedimentation rate 14.02 10.28 25 273221 1055 42347034
Intervertebral disc degeneration 14.00 10.28 88 273158 7279 42340810
Myoclonus 13.98 10.28 59 273187 17006 42331083
Hyperammonaemia 13.89 10.28 18 273228 7848 42340241
Facial pain 13.82 10.28 5 273241 4255 42343834
Drug intolerance 13.74 10.28 639 272607 79785 42268304
Hepatocellular injury 13.74 10.28 92 273154 23586 42324503
Graft versus host disease 13.73 10.28 40 273206 12885 42335204
Cutaneous T-cell lymphoma stage I 13.70 10.28 9 273237 114 42347975
Melaena 13.56 10.28 171 273075 38575 42309514
Haemangioma congenital 13.54 10.28 17 273229 522 42347567
Progressive multifocal leukoencephalopathy 13.54 10.28 34 273212 11502 42336587
Post procedural infection 13.52 10.28 73 273173 5712 42342377
Disability assessment scale score increased 13.52 10.28 15 273231 403 42347686
Patent ductus arteriosus 13.51 10.28 51 273195 3425 42344664
Parosmia 13.47 10.28 90 273156 7601 42340488
Capillaritis 13.47 10.28 38 273208 2190 42345899
Erectile dysfunction 13.37 10.28 99 273147 24814 42323275
Arrhythmia 13.35 10.28 180 273066 40137 42307952
Diplopia 13.31 10.28 76 273170 20240 42327849
Eye pain 13.27 10.28 60 273186 16970 42331119
Haemolysis 13.23 10.28 106 273140 9483 42338606
Osteopenia 13.20 10.28 77 273169 6201 42341888
Hepatic steatosis 13.20 10.28 202 273044 21246 42326843
Forced expiratory volume decreased 13.19 10.28 89 273157 7541 42340548
Hypertelorism 13.19 10.28 18 273228 601 42347488
Blood immunoglobulin E increased 13.12 10.28 52 273194 3573 42344516
Scoliosis 13.10 10.28 47 273199 3079 42345010
Gastrointestinal infection 13.09 10.28 81 273165 6662 42341427
Endophthalmitis 13.09 10.28 6 273240 4427 42343662
Hepatitis E antibody positive 13.08 10.28 12 273234 255 42347834
Second primary malignancy 13.05 10.28 26 273220 9549 42338540
Arthritis bacterial 13.02 10.28 73 273173 5795 42342294
Spondyloarthropathy 12.97 10.28 22 273224 892 42347197
Folate deficiency 12.89 10.28 32 273214 1707 42346382
Electrocardiogram QRS complex prolonged 12.89 10.28 11 273235 5812 42342277
Vitamin B12 deficiency 12.82 10.28 64 273182 4858 42343231
Peritoneal dialysis complication 12.78 10.28 34 273212 1893 42346196
N-telopeptide urine increased 12.76 10.28 6 273240 37 42348052
Vision blurred 12.74 10.28 255 272991 53444 42294645
Pulmonary pain 12.73 10.28 30 273216 1548 42346541
Drug eruption 12.72 10.28 91 273155 22984 42325105
Eosinophil count decreased 12.71 10.28 51 273195 3525 42344564
Maternal exposure timing unspecified 12.62 10.28 14 273232 376 42347713
Steroid dependence 12.59 10.28 80 273166 6642 42341447
Tumour lysis syndrome 12.59 10.28 87 273159 22144 42325945
Multimorbidity 12.57 10.28 22 273224 915 42347174
Dry skin 12.56 10.28 226 273020 48112 42299977
Inguinal hernia 12.56 10.28 99 273147 8813 42339276
Interstitial lung disease 12.55 10.28 395 272851 78067 42270022
Bronchiolitis 12.54 10.28 54 273192 3852 42344237
Granuloma skin 12.52 10.28 25 273221 1150 42346939
Cytomegalovirus chorioretinitis 12.48 10.28 7 273239 4604 42343485
Viral mutation identified 12.47 10.28 3 273243 3328 42344761
Oesophageal fibrosis 12.46 10.28 10 273236 176 42347913
C-reactive protein decreased 12.42 10.28 37 273209 2199 42345890
Glycosylated haemoglobin increased 12.32 10.28 42 273204 12882 42335207
Synovial cyst 12.30 10.28 41 273205 2588 42345501
Drug-induced liver injury 12.27 10.28 172 273074 38101 42309988
Potentiating drug interaction 12.27 10.28 14 273232 6454 42341635
Tooth malformation 12.23 10.28 10 273236 181 42347908
Abortion spontaneous 12.21 10.28 14 273232 390 42347699
Septic arthritis staphylococcal 12.21 10.28 16 273230 513 42347576
Macrognathia 12.17 10.28 3 273243 0 42348089
Pancreatic duct rupture 12.17 10.28 3 273243 0 42348089
Ventricular tachycardia 12.16 10.28 129 273117 30031 42318058
Carcinoid tumour of the small bowel 12.07 10.28 14 273232 395 42347694
Candida infection 12.02 10.28 85 273161 21525 42326564
Hernia pain 12.00 10.28 12 273234 285 42347804
Blood calcium increased 11.96 10.28 94 273152 8360 42339729
Vitamin D decreased 11.96 10.28 59 273187 4456 42343633
Anti-cyclic citrullinated peptide antibody positive 11.94 10.28 33 273213 1879 42346210
Hypopnoea 11.91 10.28 89 273157 7793 42340296
Pleuritic pain 11.91 10.28 82 273164 6995 42341094
Hydrocele 11.84 10.28 40 273206 2543 42345546
Restlessness 11.83 10.28 125 273121 29124 42318965
Hypertransaminasaemia 11.78 10.28 26 273220 9201 42338888
Rhinitis 11.74 10.28 123 273123 11854 42336235
Unintentional medical device removal 11.70 10.28 3 273243 3188 42344901
Peritonitis 11.67 10.28 176 273070 18457 42329632
Neck mass 11.62 10.28 32 273214 1818 42346271
Nerve degeneration 11.61 10.28 10 273236 195 42347894
Attention deficit hyperactivity disorder 11.59 10.28 45 273201 3063 42345026
Neutropenia neonatal 11.57 10.28 21 273225 899 42347190
Ulna fracture 11.56 10.28 14 273232 414 42347675
Blood insulin increased 11.52 10.28 13 273233 356 42347733
Lung disorder 11.50 10.28 395 272851 47528 42300561
Gross motor delay 11.46 10.28 13 273233 358 42347731
Immunosuppression 11.42 10.28 93 273153 8360 42339729
Microcephaly 11.34 10.28 21 273225 913 42347176
Blood calcium decreased 11.33 10.28 115 273131 10993 42337096
Cleft palate 11.29 10.28 17 273229 622 42347467
Autoscopy 11.28 10.28 11 273235 253 42347836
Dysstasia 11.26 10.28 139 273107 13947 42334142
Nocardiosis 11.25 10.28 10 273236 5180 42342909
Blood folate increased 11.25 10.28 12 273234 308 42347781
Cardiotoxicity 11.23 10.28 19 273227 7426 42340663
Increased upper airway secretion 11.20 10.28 39 273207 2517 42345572
Hepatitis B 11.20 10.28 16 273230 6695 42341394
Gangrene neonatal 11.20 10.28 10 273236 205 42347884
Strongyloidiasis 11.18 10.28 4 273242 3427 42344662
Cystitis bacterial 11.16 10.28 10 273236 206 42347883
Low set ears 11.14 10.28 15 273231 494 42347595
Pancreatitis acute 11.06 10.28 150 273096 33414 42314675
Hallucination, visual 11.06 10.28 84 273162 20936 42327153
Irritability 11.06 10.28 121 273125 28007 42320082
Shock haemorrhagic 11.06 10.28 60 273186 16182 42331907
Growth hormone deficiency 11.00 10.28 12 273234 316 42347773
Drug level increased 10.99 10.28 111 273135 26089 42322000
Neck pain 10.99 10.28 261 272985 29753 42318336
Arnold-Chiari malformation 10.99 10.28 13 273233 375 42347714
Apparent death 10.98 10.28 5 273241 3703 42344386
Vein disorder 10.94 10.28 34 273212 2068 42346021
Dyskinesia 10.89 10.28 107 273139 25283 42322806
Blindness 10.86 10.28 69 273177 17909 42330180
Bone cyst 10.81 10.28 29 273217 1622 42346467
Blister infected 10.80 10.28 15 273231 509 42347580
Cerebral infarction 10.75 10.28 138 273108 31031 42317058
Acute graft versus host disease in intestine 10.69 10.28 6 273240 3945 42344144
Spinal stenosis 10.64 10.28 74 273172 6332 42341757
Hyperammonaemic crisis 10.59 10.28 6 273240 57 42348032
Ulcer 10.57 10.28 156 273090 16285 42331804
Diabetic ketoacidosis 10.57 10.28 92 273154 22275 42325814
Contusion 10.57 10.28 348 272898 41637 42306452
Atypical fracture 10.55 10.28 9 273237 173 42347916
Polydactyly 10.55 10.28 24 273222 1210 42346879
Juvenile idiopathic arthritis 10.49 10.28 39 273207 2600 42345489
Developmental coordination disorder 10.47 10.28 10 273236 224 42347865
Paradoxical drug reaction 10.43 10.28 9 273237 4729 42343360
Cardio-respiratory arrest 10.42 10.28 291 272955 58345 42289744
Collagen disorder 10.40 10.28 8 273238 132 42347957
Septic shock 10.36 10.28 481 272765 91191 42256898
Anal atresia 10.35 10.28 11 273235 281 42347808
Asymptomatic bacteriuria 10.33 10.28 10 273236 228 42347861
Viral infection 10.32 10.28 202 273044 22281 42325808
Secretion discharge 10.32 10.28 84 273162 7551 42340538
Fungal infection 10.29 10.28 79 273167 19643 42328446
Hypertriglyceridaemia 10.28 10.28 32 273214 10094 42337995

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 1465.49 10.03 175 944750 242206 109402168
Toxicity to various agents 1340.68 10.03 1278 943647 479277 109165097
Drug abuse 877.96 10.03 217 944708 177194 109467180
Systemic lupus erythematosus 875.39 10.03 4394 940531 249944 109394430
Arthropathy 848.56 10.03 4761 940164 282761 109361613
Synovitis 827.74 10.03 4567 940358 269525 109374849
Pemphigus 807.95 10.03 3804 941121 210766 109433608
Hand deformity 792.45 10.03 3832 941093 214674 109429700
Joint swelling 734.21 10.03 6368 938557 436477 109207897
Glossodynia 732.03 10.03 3790 941135 218214 109426160
Rheumatoid arthritis 679.93 10.03 4637 940288 294976 109349398
Intentional overdose 673.44 10.03 153 944772 132348 109512026
Wound 637.94 10.03 3800 941125 230637 109413737
Drug interaction 625.90 10.03 2184 942741 497999 109146375
Anti-cyclic citrullinated peptide antibody positive 620.89 10.03 3137 941788 178847 109465527
Pericarditis 615.77 10.03 3582 941343 215532 109428842
Abdominal discomfort 567.52 10.03 5496 939429 388362 109256012
Maternal exposure during pregnancy 554.65 10.03 3905 941020 250978 109393396
Milk-alkali syndrome 550.40 10.03 291 944634 1714 109642660
Arthralgia 550.02 10.03 9534 935391 770098 108874276
Death 534.02 10.03 3637 941288 695232 108949142
Helicobacter infection 525.78 10.03 2996 941929 178881 109465493
Duodenal ulcer perforation 525.45 10.03 2945 941980 174755 109469619
Infusion related reaction 496.18 10.03 5209 939716 375953 109268421
Swelling 486.77 10.03 4860 940065 346181 109298193
Alopecia 463.59 10.03 4961 939964 359792 109284582
Psoriatic arthropathy 457.26 10.03 3064 941861 193697 109450677
Pain 413.50 10.03 10878 934047 944077 108700297
Suicide attempt 392.58 10.03 196 944729 103198 109541176
Rheumatoid factor positive 389.94 10.03 2183 942742 129457 109514917
Therapeutic product effect decreased 389.57 10.03 3485 941440 240831 109403543
Nasopharyngitis 387.37 10.03 5106 939819 389255 109255119
Discomfort 386.74 10.03 3147 941778 211560 109432814
Musculoskeletal stiffness 380.48 10.03 3859 941066 275963 109368411
Hepatic enzyme increased 379.42 10.03 4303 940622 316589 109327785
Febrile neutropenia 356.22 10.03 1444 943481 315323 109329051
Impaired healing 352.47 10.03 2880 942045 193837 109450537
Acute kidney injury 332.06 10.03 3649 941276 631781 109012593
Disease progression 330 10.03 1029 943896 243005 109401369
Contraindicated product administered 319.04 10.03 3385 941540 244882 109399492
Folliculitis 314.20 10.03 2480 942445 165173 109479201
Cardiac arrest 301.05 10.03 782 944143 195971 109448403
Lower respiratory tract infection 293.14 10.03 3273 941652 239833 109404541
Irritable bowel syndrome 290.28 10.03 2397 942528 161818 109482556
C-reactive protein abnormal 285.34 10.03 1993 942932 127702 109516672
Malignant neoplasm progression 284.93 10.03 671 944254 173896 109470478
Muscle injury 280.58 10.03 2113 942812 138694 109505680
Blister 272.21 10.03 3057 941868 224319 109420055
Lactic acidosis 269.94 10.03 237 944688 92574 109551800
Sinusitis 268.84 10.03 3787 941138 292901 109351473
Myelosuppression 267.10 10.03 247 944678 94093 109550281
Overdose 266.39 10.03 1060 943865 232734 109411640
Rheumatic fever 262.27 10.03 1871 943054 120708 109523666
Drug resistance 261.77 10.03 78 944847 56296 109588078
Drug ineffective for unapproved indication 260.80 10.03 296 944629 102542 109541832
Fibromyalgia 257.13 10.03 2408 942517 168501 109475873
Hepatic function abnormal 254.93 10.03 232 944693 89063 109555311
Sleep disorder due to general medical condition, insomnia type 246.40 10.03 1647 943278 103996 109540378
Osteoarthritis 245.88 10.03 2514 942411 180109 109464265
Coma 243.55 10.03 394 944531 117475 109526899
Exposure during pregnancy 242.49 10.03 2340 942585 165084 109479290
Depressed level of consciousness 240.85 10.03 366 944559 111912 109532462
Bradycardia 238.73 10.03 617 944308 154900 109489474
Drug intolerance 237.54 10.03 4832 940093 401680 109242694
Neutropenia 235.48 10.03 2056 942869 372564 109271810
Drug reaction with eosinophilia and systemic symptoms 226.48 10.03 220 944705 81875 109562499
Off label use 225.43 10.03 10505 934420 1489680 108154694
Multiple organ dysfunction syndrome 217.78 10.03 622 944303 151088 109493286
Rhabdomyolysis 216.09 10.03 439 944486 119962 109524412
Serotonin syndrome 215.85 10.03 118 944807 59035 109585339
Ill-defined disorder 215.81 10.03 2169 942756 154684 109489690
Peripheral swelling 211.01 10.03 4725 940200 399309 109245065
Hypotension 203.35 10.03 3199 941726 520650 109123724
Arthritis 202.71 10.03 2258 942667 165328 109479046
Swollen joint count increased 202.18 10.03 1316 943609 82345 109562029
Respiratory failure 200.70 10.03 1051 943874 214281 109430093
Intentional product misuse 195.87 10.03 538 944387 132366 109512008
Contusion 195.23 10.03 2938 941987 230423 109413951
Weight increased 194.17 10.03 4826 940099 414818 109229556
Joint range of motion decreased 193.06 10.03 1736 943189 120096 109524278
Respiratory arrest 189.58 10.03 133 944792 58166 109586208
Angioedema 189.09 10.03 345 944580 98155 109546219
Agitation 187.29 10.03 431 944494 112620 109531754
Somnolence 185.29 10.03 1636 943289 295813 109348561
Type 2 diabetes mellitus 182.23 10.03 2315 942610 174917 109469457
Cardiac failure 182.09 10.03 903 944022 186723 109457651
Facet joint syndrome 178.95 10.03 1428 943497 95400 109548974
Sickle cell anaemia with crisis 177.56 10.03 304 944621 9241 109635133
Sedation 177.30 10.03 200 944725 69483 109574891
Stomatitis 175.95 10.03 3266 941659 266976 109377398
Sopor 174.42 10.03 48 944877 36498 109607876
Inflammation 174.29 10.03 2465 942460 190773 109453601
Electrocardiogram QT prolonged 173.65 10.03 424 944501 108536 109535838
Hyperhidrosis 171.28 10.03 920 944005 186378 109457996
Hypersensitivity 170.52 10.03 4590 940335 399408 109244966
Altered state of consciousness 162.97 10.03 151 944774 57475 109586899
Red blood cell sedimentation rate abnormal 162.41 10.03 520 944405 23989 109620385
Renal impairment 160.20 10.03 948 943977 187497 109456877
Hyponatraemia 158.19 10.03 1148 943777 216505 109427869
Grip strength decreased 157.90 10.03 1200 943725 78974 109565400
Blood pressure systolic increased 155.04 10.03 1227 943698 81764 109562610
Lip dry 151.91 10.03 1413 943512 98670 109545704
Mobility decreased 151.29 10.03 2860 942065 234562 109409812
Cytomegalovirus infection 151.22 10.03 145 944780 54299 109590075
Cardio-respiratory arrest 150.52 10.03 497 944428 115339 109529035
Product use in unapproved indication 149.30 10.03 2807 942118 444570 109199804
Knee arthroplasty 148.68 10.03 1008 943917 63940 109580434
Tachycardia 146.27 10.03 1235 943690 225410 109418964
Renal failure 146.05 10.03 1235 943690 225339 109419035
Pregnancy 145.96 10.03 839 944086 50228 109594146
Respiratory depression 145.47 10.03 46 944879 31955 109612419
Drug dependence 145.12 10.03 128 944797 49892 109594482
Blood pressure systolic abnormal 144.05 10.03 504 944421 24346 109620028
Hepatic failure 143.66 10.03 228 944697 68511 109575863
Blood cholesterol increased 143.64 10.03 2298 942627 182487 109461887
Intentional self-injury 143.50 10.03 70 944855 37359 109607015
Shock 142.78 10.03 148 944777 53440 109590934
Blood pressure diastolic abnormal 141.46 10.03 514 944411 25301 109619073
Poisoning 141.22 10.03 37 944888 29068 109615306
Blood pressure fluctuation 140.73 10.03 1108 943817 73716 109570658
Thrombocytopenia 139.84 10.03 2117 942808 346768 109297606
Hypoglycaemia 137.57 10.03 518 944407 115586 109528788
Musculoskeletal pain 137.39 10.03 2263 942662 180760 109463614
Hip arthroplasty 136.09 10.03 880 944045 54933 109589441
Drug use disorder 128.96 10.03 6 944919 18068 109626306
Live birth 126.89 10.03 1022 943903 68462 109575912
Pain in extremity 126.49 10.03 5227 939698 481891 109162483
Pulmonary fibrosis 124.77 10.03 1378 943547 100664 109543710
Anaphylactic shock 124.65 10.03 154 944771 51392 109592982
Metabolic acidosis 124.12 10.03 436 944489 99308 109545066
Injury 124.01 10.03 2167 942758 175098 109469276
Neoplasm progression 123.30 10.03 227 944698 64368 109580006
Cytokine release syndrome 122.21 10.03 261 944664 70045 109574329
Wheezing 122.05 10.03 2949 941976 252281 109392093
Psoriasis 120.32 10.03 1771 943154 138222 109506152
Constipation 118.04 10.03 2249 942676 355537 109288837
Neuroleptic malignant syndrome 117.09 10.03 73 944852 33986 109610388
Shunt stenosis 117.02 10.03 97 944828 1319 109643055
Gastrointestinal disorder 116.72 10.03 2799 942126 239153 109405221
Product use issue 115.79 10.03 3485 941440 308210 109336164
Suspected suicide 115.57 10.03 3 944922 15196 109629178
Treatment failure 114.94 10.03 3143 941782 274091 109370283
C-reactive protein increased 114.71 10.03 2552 942373 215367 109429007
Bursitis 110.65 10.03 1641 943284 128277 109516097
Wound infection 109.96 10.03 1285 943640 95180 109549194
Syncope 109.12 10.03 1154 943771 201382 109442992
Suicidal ideation 108.77 10.03 423 944502 93514 109550860
Neuropathy peripheral 108.10 10.03 994 943931 178283 109466091
Sepsis 106.34 10.03 2063 942862 325283 109319091
Seizure 105.94 10.03 1294 943631 219891 109424483
Red blood cell sedimentation rate increased 105.83 10.03 1079 943846 77223 109567151
Abortion spontaneous 105.78 10.03 575 944350 33707 109610667
Hypercalcaemia 105.52 10.03 722 944203 45935 109598439
Palmar-plantar erythrodysaesthesia syndrome 105.18 10.03 117 944808 40908 109603466
Joint effusion 104.37 10.03 404 944521 20501 109623873
Hepatocellular injury 103.92 10.03 170 944755 50472 109593902
Sciatica 103.18 10.03 1226 943699 91173 109553201
Intentional product use issue 102.89 10.03 2811 942114 245095 109399279
Anaphylactic reaction 102.51 10.03 565 944360 113735 109530639
Osteoporosis 102.49 10.03 1168 943757 85984 109558390
Disturbance in attention 101.34 10.03 238 944687 61757 109582617
Hyperglycaemia 101.21 10.03 379 944546 84711 109559663
Peripheral venous disease 101.04 10.03 1132 943793 82985 109561389
Acute hepatic failure 100.26 10.03 98 944827 36370 109608004
Deep vein thrombosis postoperative 99.15 10.03 855 944070 58436 109585938
Accidental exposure to product 97.90 10.03 173 944752 49835 109594539
Fatigue 97.28 10.03 11835 933090 1204123 108440251
Infection 97.26 10.03 3901 941024 358299 109286075
Neutrophil count decreased 96.73 10.03 620 944305 120321 109524053
Bone erosion 95.79 10.03 702 944223 45669 109598705
Myocardial infarction 95.72 10.03 1114 943811 190969 109453405
Breast cancer stage III 95.61 10.03 1066 943859 78051 109566323
Wrong technique in product usage process 95.06 10.03 403 944522 86945 109557429
Disseminated intravascular coagulation 95.03 10.03 128 944797 41158 109603216
Drug withdrawal syndrome 94.88 10.03 111 944814 37943 109606431
Venoocclusive liver disease 94.30 10.03 10 944915 15197 109629177
Aggression 93.86 10.03 231 944694 58979 109585395
Therapy partial responder 93.59 10.03 107 944818 36954 109607420
Mydriasis 93.58 10.03 36 944889 22121 109622253
Restlessness 93.56 10.03 214 944711 56045 109588329
Liver injury 92.73 10.03 1803 943122 148610 109495764
Disability assessment scale score increased 91.57 10.03 145 944780 4125 109640249
Ventricular tachycardia 90.00 10.03 182 944743 49827 109594547
Temperature regulation disorder 89.16 10.03 5 944920 12821 109631553
Joint stiffness 88.68 10.03 922 944003 66321 109578053
Post transplant lymphoproliferative disorder 87.85 10.03 14 944911 15599 109628775
Lower limb fracture 87.79 10.03 1008 943917 74340 109570034
Dry skin 87.57 10.03 549 944376 107104 109537270
Miosis 87.54 10.03 39 944886 21944 109622430
Anaemia 87.44 10.03 3802 941123 543284 109101090
Foot deformity 87.39 10.03 711 944214 47769 109596605
Vision blurred 86.87 10.03 695 944230 128327 109516047
Exposure to toxic agent 86.43 10.03 6 944919 12852 109631522
Blood creatine phosphokinase increased 85.93 10.03 327 944598 72750 109571624
Gait inability 85.85 10.03 1640 943285 134736 109509638
Condition aggravated 85.78 10.03 7341 937584 727495 108916879
Blood pressure diastolic decreased 85.78 10.03 563 944362 35322 109609052
Obesity 85.57 10.03 1403 943522 111948 109532426
Torsade de pointes 85.53 10.03 43 944882 22557 109621817
Tremor 85.18 10.03 1215 943710 201017 109443357
Pathogen resistance 84.73 10.03 23 944902 17649 109626725
Withdrawal syndrome 84.35 10.03 86 944839 31294 109613080
Hallucination 83.17 10.03 516 944409 100916 109543458
Leukopenia 82.49 10.03 842 944083 147949 109496425
Road traffic accident 82.07 10.03 1332 943593 106066 109538308
Encephalopathy 81.56 10.03 385 944540 80670 109563704
Cerebral haemorrhage 81.49 10.03 283 944642 64685 109579689
Cytomegalovirus infection reactivation 80.44 10.03 28 944897 18305 109626069
Femur fracture 78.99 10.03 650 944275 43819 109600555
Heart rate decreased 78.76 10.03 1066 943859 81690 109562684
Cardiogenic shock 78.69 10.03 240 944685 57098 109587276
Hypoxia 78.54 10.03 717 944208 128798 109515576
Substance abuse 77.79 10.03 8 944917 12455 109631919
Cholestasis 77.63 10.03 286 944639 64232 109580142
Brain oedema 77.22 10.03 91 944834 31007 109613367
Autoimmune disorder 77.17 10.03 878 944047 64605 109579769
Hyperkalaemia 76.30 10.03 766 944159 135030 109509344
Loss of consciousness 76.26 10.03 1198 943727 195108 109449266
BK virus infection 75.46 10.03 11 944914 13095 109631279
Shunt occlusion 74.72 10.03 83 944842 1654 109642720
Adjustment disorder with depressed mood 73.47 10.03 633 944292 43250 109601124
Interstitial lung disease 73.38 10.03 798 944127 138536 109505838
Extrapyramidal disorder 73.27 10.03 83 944842 28784 109615590
Haematotoxicity 72.73 10.03 45 944880 21037 109623337
Blood glucose increased 72.54 10.03 752 944173 131744 109512630
Acute respiratory distress syndrome 72.06 10.03 224 944701 52974 109591400
Akathisia 71.95 10.03 28 944897 17085 109627289
Platelet count decreased 71.87 10.03 1462 943463 228981 109415393
Acute graft versus host disease 71.47 10.03 12 944913 12869 109631505
Nodule 70.87 10.03 500 944425 32131 109612243
Dislocation of vertebra 69.74 10.03 624 944301 43097 109601277
Cerebral infarction 69.71 10.03 219 944706 51619 109592755
Mucormycosis 68.51 10.03 6 944919 10622 109633752
Aspergillus infection 67.95 10.03 71 944854 25545 109618829
Ascites 67.15 10.03 490 944435 92318 109552056
Dystonia 66.81 10.03 73 944852 25732 109618642
Hypothermia 66.35 10.03 76 944849 26226 109618148
Enthesopathy 66.30 10.03 246 944679 12232 109632142
Loss of personal independence in daily activities 65.91 10.03 1714 943211 148306 109496068
Neurotoxicity 65.86 10.03 166 944759 42041 109602333
Immune reconstitution inflammatory syndrome 65.86 10.03 28 944897 16198 109628176
Lung disorder 65.17 10.03 2007 942918 178040 109466334
Diabetic ketoacidosis 65.17 10.03 166 944759 41892 109602482
No adverse event 65.11 10.03 367 944558 73472 109570902
Abnormal behaviour 64.51 10.03 149 944776 38890 109605484
Hypoaesthesia 64.39 10.03 3293 941632 310930 109333444
Irritability 64.27 10.03 202 944723 47607 109596767
Device difficult to use 63.69 10.03 41 944884 18764 109625610
Bronchopulmonary aspergillosis 63.40 10.03 98 944827 29765 109614609
Polyarthritis 63.26 10.03 325 944600 18638 109625736
Exposure via skin contact 63.24 10.03 17 944908 13130 109631244
Hypercholesterolaemia 62.62 10.03 1108 943817 89729 109554645
Posterior reversible encephalopathy syndrome 61.99 10.03 122 944803 33739 109610635
Dry mouth 61.89 10.03 2188 942737 197760 109446614
Respiratory distress 61.45 10.03 341 944584 68533 109575841
Juvenile idiopathic arthritis 61.13 10.03 149 944776 5858 109638516
Cardiac failure congestive 60.86 10.03 915 944010 150085 109494289
Drug dose omission by device 60.62 10.03 24 944901 14492 109629882
Unintentional medical device removal 60.45 10.03 4 944921 8919 109635455
Proteinuria 60.44 10.03 160 944765 39858 109604516
Stevens-Johnson syndrome 60.38 10.03 202 944723 46699 109597675
Inappropriate antidiuretic hormone secretion 60.23 10.03 124 944801 33727 109610647
Disease recurrence 59.82 10.03 291 944634 60493 109583881
Drug level increased 59.75 10.03 208 944717 47511 109596863
Dehydration 59.73 10.03 1875 943050 277636 109366738
Acute graft versus host disease in skin 59.60 10.03 10 944915 10730 109633644
Ventricular fibrillation 59.54 10.03 169 944756 41144 109603230
Joint destruction 59.21 10.03 217 944708 10726 109633648
Gamma-glutamyltransferase increased 58.91 10.03 296 944629 61013 109583361
Psychomotor hyperactivity 58.68 10.03 52 944873 20225 109624149
Injection site reaction 58.42 10.03 1078 943847 87992 109556382
Adverse event 58.41 10.03 1278 943647 107531 109536843
Dyskinesia 58.07 10.03 234 944691 51212 109593162
Arrhythmia 58.04 10.03 352 944573 69223 109575151
Thrombotic microangiopathy 57.82 10.03 100 944825 29049 109615325
COVID-19 57.81 10.03 1622 943303 243438 109400936
Myoclonus 57.76 10.03 122 944803 32876 109611498
Drug ineffective 57.70 10.03 11795 933130 1508745 108135629
Graft versus host disease 57.16 10.03 46 944879 18760 109625614
Exostosis 56.34 10.03 621 944304 45335 109599039
Hypokalaemia 55.84 10.03 1161 943764 181287 109463087
Haemophagocytic lymphohistiocytosis 55.82 10.03 116 944809 31443 109612931
Tachypnoea 55.42 10.03 163 944762 39232 109605142
Graft versus host disease in gastrointestinal tract 55.35 10.03 6 944919 8962 109635412
Multiple-drug resistance 55.07 10.03 22 944903 13213 109631161
Cytomegalovirus viraemia 54.56 10.03 43 944882 17721 109626653
Blood pressure diastolic increased 54.40 10.03 310 944615 18497 109625877
C-reactive protein 54.22 10.03 444 944481 29887 109614487
Melaena 53.69 10.03 355 944570 68402 109575972
Adenovirus infection 53.29 10.03 14 944911 10980 109633394
Rheumatoid nodule 53.20 10.03 326 944599 19970 109624404
Tumour lysis syndrome 52.98 10.03 115 944810 30686 109613688
General physical health deterioration 52.90 10.03 4270 940655 421025 109223349
Agranulocytosis 52.82 10.03 310 944615 61450 109582924
Second primary malignancy 52.69 10.03 46 944879 18022 109626352
Myalgia 52.68 10.03 1471 943454 220910 109423464
Device expulsion 52.59 10.03 116 944809 30775 109613599
Unresponsive to stimuli 52.55 10.03 324 944601 63466 109580908
Pancreatitis acute 52.37 10.03 301 944624 59973 109584401
Joint laxity 52.21 10.03 84 944841 2423 109641951
Tenosynovitis 52.20 10.03 276 944649 16007 109628367
Dermatitis atopic 52.16 10.03 86 944839 25455 109618919
Coagulopathy 52.12 10.03 177 944748 40734 109603640
Ejection fraction decreased 51.99 10.03 177 944748 40703 109603671
Rebound effect 51.92 10.03 31 944894 14775 109629599
Status epilepticus 51.76 10.03 121 944804 31450 109612924
Night sweats 51.30 10.03 1504 943421 132479 109511895
Finger deformity 51.10 10.03 469 944456 32623 109611751
Body temperature decreased 50.88 10.03 511 944414 36424 109607950
Septic shock 50.73 10.03 994 943931 156534 109487840
Laryngitis 50.13 10.03 569 944356 41842 109602532
Speech disorder 50.06 10.03 314 944611 61255 109583119
Lupus-like syndrome 49.91 10.03 551 944374 40241 109604133
Caesarean section 49.76 10.03 242 944683 13575 109630799
Polyomavirus-associated nephropathy 49.33 10.03 6 944919 8195 109636179
Sleep disorder 48.83 10.03 2120 942805 196524 109447850
Flushing 48.52 10.03 617 944308 104119 109540255
Pulmonary oedema 48.50 10.03 588 944337 100071 109544303
Atrial fibrillation 48.20 10.03 1544 943381 228098 109416276
Face oedema 48.17 10.03 137 944788 33332 109611042
Localised infection 47.96 10.03 571 944354 42477 109601897
Acute myeloid leukaemia 47.13 10.03 167 944758 37943 109606431
Urinary retention 47.06 10.03 375 944550 69308 109575066
Onychomadesis 46.70 10.03 596 944329 45067 109599307
Paradoxical drug reaction 46.65 10.03 13 944912 9804 109634570
Onychomycosis 46.47 10.03 519 944406 38012 109606362
Gestational diabetes 46.46 10.03 154 944771 7235 109637139
Cognitive disorder 46.15 10.03 501 944424 87010 109557364
Disorientation 45.59 10.03 385 944540 70286 109574088
Rash maculo-papular 45.38 10.03 410 944515 73812 109570562
X-ray abnormal 45.33 10.03 512 944413 37605 109606769
Cytopenia 45.03 10.03 121 944804 29995 109614379
Erythema multiforme 45.01 10.03 69 944856 21028 109623346
Recalled product 44.87 10.03 50 944875 1000 109643374
Food allergy 44.75 10.03 63 944862 19885 109624489
Nausea 44.69 10.03 9607 935318 1226083 108418291
Basal cell carcinoma 44.25 10.03 586 944339 44684 109599690
Acute generalised exanthematous pustulosis 44.19 10.03 73 944852 21591 109622783
Diarrhoea 43.61 10.03 8834 936091 1130671 108513703
Mania 43.43 10.03 69 944856 20727 109623647
Oedema 43.29 10.03 2202 942723 207774 109436600
Toxic skin eruption 43.10 10.03 108 944817 27407 109616967
Hyperthermia 43.09 10.03 72 944853 21200 109623174
Rash 43.06 10.03 7803 937122 813161 108831213
Lymphocyte count decreased 42.49 10.03 300 944625 56943 109587431
Cardiotoxicity 42.34 10.03 49 944876 16832 109627542
Epstein-Barr virus infection 42.21 10.03 59 944866 18679 109625695
Cystitis haemorrhagic 42.20 10.03 26 944899 12183 109632191
Bradyphrenia 41.91 10.03 24 944901 11704 109632670
Myocarditis 41.81 10.03 125 944800 29930 109614444
Hallucination, visual 41.70 10.03 185 944740 39420 109604954
Anti-cyclic citrullinated peptide antibody 41.67 10.03 303 944622 19661 109624713
Retinitis 41.56 10.03 441 944484 31886 109612488
Blepharospasm 41.41 10.03 679 944246 54172 109590202
Bronchospasm 41.19 10.03 127 944798 30112 109614262
Metastases to liver 41.18 10.03 159 944766 35227 109609147
Blood parathyroid hormone decreased 40.69 10.03 220 944705 12869 109631505
Haemorrhage intracranial 40.65 10.03 120 944805 28849 109615525
Pulmonary vasculitis 40.60 10.03 136 944789 6424 109637950
Chronic graft versus host disease 40.55 10.03 15 944910 9442 109634932
Respiratory symptom 40.41 10.03 242 944683 14703 109629671
Metastases to central nervous system 40.24 10.03 84 944841 22733 109621641
Pneumonia aspiration 40.10 10.03 472 944453 80761 109563613
Dissociation 39.92 10.03 17 944908 9825 109634549
Diffuse large B-cell lymphoma recurrent 39.43 10.03 4 944921 6295 109638079
Neuritis 39.42 10.03 146 944779 7253 109637121
Maternal exposure timing unspecified 39.41 10.03 311 944614 20702 109623672
White blood cell count decreased 39.34 10.03 1581 943344 227809 109416565
Maternal exposure before pregnancy 39.25 10.03 144 944781 7121 109637253
Acute chest syndrome 39.15 10.03 67 944858 2036 109642338
Metastases to lung 38.94 10.03 87 944838 22976 109621398
Shock haemorrhagic 38.87 10.03 112 944813 27135 109617239
Parkinsonism 38.86 10.03 82 944843 22105 109622269
Blood creatinine increased 38.77 10.03 1228 943697 181661 109462713
Sinus tachycardia 38.76 10.03 222 944703 44271 109600103
Febrile bone marrow aplasia 38.35 10.03 56 944869 17409 109626965
Ear infection 37.97 10.03 750 944175 61982 109582392
Blood pressure increased 37.96 10.03 2629 942296 255744 109388630
Multiple sclerosis relapse 37.93 10.03 262 944663 49978 109594396
Device leakage 37.70 10.03 49 944876 15999 109628375
Lupus vulgaris 37.56 10.03 449 944476 33434 109610940
Sinus congestion 37.52 10.03 412 944513 30047 109614327
Generalised tonic-clonic seizure 37.51 10.03 293 944632 54387 109589987
Blood pressure decreased 37.42 10.03 725 944200 114366 109530008
Haemodynamic instability 37.30 10.03 88 944837 22800 109621574
Polyneuropathy 37.15 10.03 144 944781 31868 109612506
Product prescribing error 37.14 10.03 271 944654 51060 109593314
Electrocardiogram QRS complex prolonged 36.95 10.03 34 944891 12987 109631387
Hypomania 36.90 10.03 179 944746 10031 109634343
Hepatic encephalopathy 36.85 10.03 121 944804 28135 109616239
Hepatic cirrhosis 36.51 10.03 795 944130 66831 109577543
Wheelchair user 36.29 10.03 148 944777 7694 109636680
Nail disorder 36.20 10.03 696 944229 57239 109587135
Aspartate aminotransferase increased 36.08 10.03 1065 943860 158871 109485503
Sinus bradycardia 35.92 10.03 130 944795 29353 109615021
Eosinophilia 35.87 10.03 319 944606 57617 109586757
Tongue disorder 35.81 10.03 227 944698 14071 109630303
Sexual dysfunction 35.79 10.03 14 944911 8516 109635858
Spinal stenosis 35.72 10.03 282 944643 18774 109625600
Nasal oedema 35.65 10.03 134 944791 6705 109637669
Circulatory collapse 35.61 10.03 218 944707 42775 109601599
Graft versus host disease in skin 35.54 10.03 13 944912 8241 109636133
Jaundice 35.44 10.03 329 944596 58907 109585467
Tendonitis 35.03 10.03 359 944566 25724 109618650
Respiratory acidosis 34.82 10.03 40 944885 13786 109630588
Acute coronary syndrome 34.45 10.03 93 944832 23019 109621355
Joint dislocation 34.43 10.03 445 944480 33745 109610629
Stress cardiomyopathy 34.39 10.03 51 944874 15755 109628619
Ischaemic stroke 34.29 10.03 209 944716 41054 109603320
Pneumatosis intestinalis 34.17 10.03 15 944910 8514 109635860
Red blood cell sedimentation rate 33.98 10.03 110 944815 5104 109639270
Hyperbilirubinaemia 33.68 10.03 141 944784 30530 109613844
Latent tuberculosis 33.61 10.03 92 944833 3885 109640489
Nocardiosis 33.60 10.03 11 944914 7475 109636899
Blindness 33.54 10.03 178 944747 36181 109608193
Potentiating drug interaction 33.52 10.03 30 944895 11613 109632761
Colorectal cancer 33.51 10.03 18 944907 9096 109635278
Fluid retention 33.50 10.03 585 944340 93722 109550652
Dyspnoea 33.47 10.03 8677 936248 1098195 108546179
Carotid artery thrombosis 33.42 10.03 167 944758 9471 109634903
Paralysis 33.30 10.03 51 944874 15549 109628825
Haemorrhage 33.21 10.03 677 944248 106015 109538359
Pseudomonas infection 33.16 10.03 124 944801 27729 109616645
Dyspepsia 32.93 10.03 1970 942955 188995 109455379
Neurologic neglect syndrome 32.88 10.03 162 944763 9136 109635238
Sleep terror 32.85 10.03 8 944917 6602 109637772
Cholelithiasis 32.79 10.03 741 944184 62681 109581693
Pulseless electrical activity 32.77 10.03 58 944867 16699 109627675
Muscle twitching 32.63 10.03 138 944787 29797 109614577
Feeling abnormal 32.62 10.03 1238 943687 179473 109464901
Candida infection 32.59 10.03 258 944667 47751 109596623
Chest discomfort 32.49 10.03 1186 943739 172662 109471712
Neck deformity 32.40 10.03 58 944867 1828 109642546
Synovial cyst 32.14 10.03 187 944738 11243 109633131
Fracture delayed union 31.97 10.03 63 944862 2138 109642236
Central nervous system lupus 31.89 10.03 48 944877 1305 109643069
Hepatitis B reactivation 31.87 10.03 12 944913 7472 109636902
Hallucination, auditory 31.76 10.03 117 944808 26280 109618094
Tenderness 31.72 10.03 388 944537 29049 109615325
Calciphylaxis 31.62 10.03 93 944832 4094 109640280
Drug effective for unapproved indication 31.52 10.03 45 944880 14122 109630252
Transplant rejection 31.49 10.03 106 944819 24461 109619913
Cardiac failure acute 31.48 10.03 103 944822 23975 109620399
Prescribed underdose 31.40 10.03 754 944171 64420 109579954
Cross sensitivity reaction 31.30 10.03 5 944920 5562 109638812
Anuria 31.22 10.03 105 944820 24236 109620138
Premature labour 31.16 10.03 158 944767 9014 109635360
Alanine aminotransferase abnormal 31.15 10.03 160 944765 9174 109635200
Product dose omission issue 31.09 10.03 2347 942578 319435 109324939
Prescribed overdose 31.07 10.03 974 943951 86607 109557767
Erythema 31.04 10.03 2108 942817 289339 109355035
Metastases to bone 30.98 10.03 150 944775 31222 109613152
Eczema 30.89 10.03 433 944492 71860 109572514
Skin toxicity 30.87 10.03 33 944892 11750 109632624
Delusion 30.79 10.03 102 944823 23653 109620721
Coronary artery disease 30.77 10.03 429 944496 71261 109573113
Rhinorrhoea 30.65 10.03 1119 943806 101547 109542827
Dermatitis acneiform 30.62 10.03 38 944887 12657 109631717
Device use error 30.53 10.03 20 944905 9069 109635305
Gastrointestinal haemorrhage 30.52 10.03 1131 943794 164387 109479987
Fear 30.47 10.03 99 944826 23094 109621280
Diplopia 30.39 10.03 221 944704 41673 109602701
Endophthalmitis 30.35 10.03 16 944909 8171 109636203
Pruritus genital 30.32 10.03 9 944916 6513 109637861
Product preparation error 30.18 10.03 29 944896 10850 109633524
Orthostatic hypotension 30.04 10.03 392 944533 65857 109578517
Colitis ulcerative 30.04 10.03 870 944055 76493 109567881
Adjustment disorder 29.96 10.03 176 944749 10619 109633755
Palmoplantar keratoderma 29.93 10.03 5 944920 5382 109638992
Atrial tachycardia 29.75 10.03 21 944904 9157 109635217
Nephropathy toxic 29.75 10.03 127 944798 27351 109617023
Cardiac failure chronic 29.63 10.03 45 944880 13766 109630608
Alanine aminotransferase increased 29.52 10.03 1276 943649 182497 109461877
Fracture 29.49 10.03 333 944592 24455 109619919
Cardiomyopathy 29.35 10.03 167 944758 33358 109611016
Accidental death 29.32 10.03 4 944921 5005 109639369
Muscle rigidity 29.25 10.03 106 944819 23925 109620449
Bladder cancer 29.25 10.03 83 944842 20209 109624165
Strongyloidiasis 29.14 10.03 4 944921 4982 109639392
Multiple fractures 28.98 10.03 152 944773 8788 109635586
Mental disorder 28.93 10.03 203 944722 38588 109605786
Arthritis infective 28.92 10.03 170 944755 10259 109634115
Eye pruritus 28.84 10.03 163 944762 32612 109611762
Pleural effusion 28.73 10.03 1233 943692 176476 109467898
Right ventricular failure 28.69 10.03 119 944806 25835 109618539
Pre-eclampsia 28.68 10.03 148 944777 8502 109635872
Premature rupture of membranes 28.58 10.03 96 944829 4541 109639833
Pyrexia 28.58 10.03 7025 937900 891240 108753134
Poor venous access 28.53 10.03 328 944597 24194 109620180
Myopathy 28.50 10.03 113 944812 24847 109619527
Immune-mediated enterocolitis 28.43 10.03 27 944898 10158 109634216
Smear cervix abnormal 28.38 10.03 68 944857 2644 109641730
Acidosis 28.35 10.03 98 944827 22433 109621941
Visual acuity reduced 28.31 10.03 160 944765 32013 109612361
Hyperammonaemia 28.26 10.03 46 944879 13686 109630688
Glycosylated haemoglobin increased 28.21 10.03 105 944820 23514 109620860
Product administered to patient of inappropriate age 27.93 10.03 17 944908 8019 109636355
Progressive multifocal leukoencephalopathy 27.85 10.03 114 944811 24842 109619532
Affective disorder 27.80 10.03 33 944892 11208 109633166
Bradypnoea 27.76 10.03 20 944905 8629 109635745
Paranoia 27.69 10.03 98 944827 22276 109622098
Acute graft versus host disease in intestine 27.68 10.03 7 944918 5632 109638742
Acute respiratory failure 27.65 10.03 464 944461 74796 109569578
Haematoma 27.63 10.03 343 944582 58133 109586241
Toxic epidermal necrolysis 27.47 10.03 331 944594 56396 109587978
Disability 27.40 10.03 386 944539 29837 109614537
Human herpesvirus 6 infection 27.29 10.03 11 944914 6570 109637804
Klebsiella infection 27.28 10.03 84 944841 19925 109624449
Therapy interrupted 27.17 10.03 283 944642 49539 109594835
Viral mutation identified 27.16 10.03 3 944922 4416 109639958
Hyperuricaemia 26.91 10.03 52 944873 14479 109629895
Acute myocardial infarction 26.85 10.03 529 944396 83248 109561126
Foot fracture 26.79 10.03 335 944590 25211 109619163
Epistaxis 26.76 10.03 879 944046 129493 109514881
Labelled drug-drug interaction medication error 26.73 10.03 144 944781 29158 109615216
Gastrooesophageal reflux disease 26.72 10.03 1833 943092 178143 109466231
Ketoacidosis 26.71 10.03 28 944897 10059 109634315
Pulmonary congestion 26.71 10.03 155 944770 30811 109613563
Hepatocellular carcinoma 26.64 10.03 27 944898 9853 109634521
Breast cancer stage I 26.57 10.03 15 944910 7372 109637002
Back injury 26.48 10.03 560 944365 46839 109597535
Neck mass 26.42 10.03 96 944829 4725 109639649
Hypernatraemia 26.40 10.03 72 944853 17761 109626613
Respiratory tract infection 26.34 10.03 800 944125 70817 109573557
Cytomegalovirus chorioretinitis 26.32 10.03 14 944911 7114 109637260
Generalised oedema 26.32 10.03 154 944771 30550 109613824
Exposure via ingestion 26.24 10.03 5 944920 4895 109639479
Immune-mediated myositis 26.21 10.03 10 944915 6176 109638198
Atrioventricular block complete 26.19 10.03 86 944839 19996 109624378
Rotator cuff repair 26.10 10.03 59 944866 2207 109642167
Leukocytosis 26.09 10.03 314 944611 53514 109590860
Product prescribing issue 26.09 10.03 43 944882 12729 109631645
Pulmonary arterial hypertension 26.01 10.03 167 944758 32401 109611973
Mucosal inflammation 25.93 10.03 624 944301 95517 109548857
Bone disorder 25.81 10.03 286 944639 20906 109623468
Pneumonia bacterial 25.68 10.03 126 944799 26135 109618239
Cyanosis 25.58 10.03 149 944776 29592 109614782
Subarachnoid haemorrhage 25.44 10.03 149 944776 29553 109614821
Hepatitis acute 25.43 10.03 79 944846 18687 109625687
Metabolic alkalosis 25.42 10.03 105 944820 5490 109638884
Granulomatous pneumonitis 25.35 10.03 19 944906 221 109644153
Hypotonia 25.29 10.03 61 944864 15684 109628690
Antineutrophil cytoplasmic antibody positive 25.26 10.03 98 944827 4978 109639396
Nephrocalcinosis 25.24 10.03 51 944874 1763 109642611
Type 1 diabetes mellitus 25.23 10.03 24 944901 9023 109635351
Vascular stent thrombosis 25.14 10.03 3 944922 4158 109640216
Hypertransaminasaemia 25.11 10.03 114 944811 24141 109620233
Psychiatric decompensation 24.96 10.03 9 944916 5756 109638618
Peripheral sensory neuropathy 24.95 10.03 67 944858 16613 109627761
Scleritis 24.85 10.03 102 944823 5318 109639056
Hypocalcaemia 24.81 10.03 733 944192 64633 109579741
Hypogammaglobulinaemia 24.81 10.03 88 944837 19988 109624386
Tardive dyskinesia 24.79 10.03 49 944876 13530 109630844
Bacteraemia 24.69 10.03 237 944688 42153 109602221
Nervous system disorder 24.65 10.03 164 944761 31557 109612817
Linear IgA disease 24.55 10.03 4 944921 4385 109639989
Emotional distress 24.35 10.03 255 944670 44592 109599782
Drug tolerance decreased 24.28 10.03 350 944575 27190 109617184
Polyhydramnios 24.16 10.03 52 944873 1881 109642493
Venoocclusive disease 24.15 10.03 12 944913 6338 109638036
Blood lactate dehydrogenase increased 24.10 10.03 252 944673 44082 109600292
Total lung capacity increased 24.07 10.03 97 944828 5015 109639359
Osteopenia 24.05 10.03 293 944632 21916 109622458
Respiration abnormal 24.04 10.03 29 944896 9780 109634594
Hypoalbuminaemia 23.95 10.03 147 944778 28827 109615547
Pulmonary haemorrhage 23.95 10.03 67 944858 16389 109627985
Depressive symptom 23.84 10.03 22 944903 8392 109635982
Premature delivery 23.80 10.03 381 944544 30251 109614123
Subdural haematoma 23.78 10.03 198 944727 36256 109608118
Confusional state 23.69 10.03 4447 940478 464233 109180141
Anosmia 23.65 10.03 44 944881 12428 109631946
Mouth ulceration 23.52 10.03 558 944367 47580 109596794
Influenza 23.51 10.03 1713 943212 167388 109476986
Rash erythematous 23.50 10.03 526 944399 81306 109563068
Limb deformity 23.49 10.03 78 944847 3668 109640706
Disturbance in social behaviour 23.48 10.03 7 944918 5051 109639323
Enterocolitis 23.45 10.03 83 944842 18866 109625508
Product administration error 23.44 10.03 204 944721 37013 109607361
Cardiac septal defect 23.41 10.03 35 944890 946 109643428
Mental status changes 23.40 10.03 484 944441 75638 109568736
Accidental overdose 23.39 10.03 307 944618 51527 109592847
Blood alkaline phosphatase increased 23.31 10.03 446 944479 70489 109573885
Bradykinesia 23.29 10.03 35 944890 10753 109633621
Antinuclear antibody positive 23.24 10.03 146 944779 9022 109635352
Transaminases increased 23.23 10.03 391 944534 62999 109581375
Malignant mediastinal neoplasm 23.19 10.03 42 944883 1336 109643038
Erectile dysfunction 23.15 10.03 81 944844 18475 109625899
Salivary hypersecretion 23.14 10.03 74 944851 17347 109627027
Hyperthermia malignant 23.10 10.03 3 944922 3897 109640477
Appendicolith 23.08 10.03 55 944870 14200 109630174
Congestive cardiomyopathy 22.91 10.03 55 944870 14164 109630210
Oliguria 22.91 10.03 82 944843 18575 109625799
Psychotic symptom 22.84 10.03 3 944922 3864 109640510
Schizophrenia 22.79 10.03 286 944639 21540 109622834
Hyperprolactinaemia 22.73 10.03 14 944911 6561 109637813
Virologic failure 22.72 10.03 7 944918 4945 109639429
Diabetes insipidus 22.70 10.03 14 944911 6556 109637818
Plantar fasciitis 22.61 10.03 95 944830 5006 109639368
Systemic mycosis 22.55 10.03 3 944922 3826 109640548
Anti-neutrophil cytoplasmic antibody positive vasculitis 22.55 10.03 9 944916 5408 109638966
Weight decreased 22.50 10.03 4430 940495 463627 109180747
Syringe issue 22.46 10.03 29 944896 9496 109634878
Immune effector cell-associated neurotoxicity syndrome 22.40 10.03 59 944866 14723 109629651
Hepatitis fulminant 22.40 10.03 24 944901 8536 109635838
Hepatitis cholestatic 22.38 10.03 76 944849 17490 109626884
Acute myeloid leukaemia recurrent 22.29 10.03 8 944917 5131 109639243
Behaviour disorder 22.11 10.03 30 944895 9617 109634757
Pulmonary hypertension 22.11 10.03 335 944590 54885 109589489
Balance disorder 22.04 10.03 794 944131 115766 109528608
Swelling face 22.02 10.03 610 944315 91711 109552663
Seronegative arthritis 22.02 10.03 190 944735 12987 109631387
Ankylosing spondylitis 21.99 10.03 217 944708 15395 109628979
Synovial disorder 21.96 10.03 66 944859 2941 109641433
Haematemesis 21.85 10.03 364 944561 58744 109585630
Hyperpyrexia 21.82 10.03 22 944903 8047 109636327
Hyperparathyroidism secondary 21.80 10.03 70 944855 3234 109641140
Spirometry abnormal 21.79 10.03 99 944826 5398 109638976
Central nervous system mass 21.70 10.03 31 944894 803 109643571
Hungry bone syndrome 21.54 10.03 20 944905 319 109644055
Wall motion score index abnormal 21.50 10.03 31 944894 810 109643564
Varicella zoster virus infection 21.41 10.03 14 944911 6354 109638020
Tuberculosis 21.25 10.03 239 944686 17535 109626839
Drug tolerance 21.20 10.03 226 944699 16359 109628015
Lymphopenia 21.16 10.03 230 944695 39940 109604434
Wrist fracture 21.09 10.03 202 944723 14215 109630159
Nightmare 21.09 10.03 221 944704 38642 109605732
COVID-19 pneumonia 21.07 10.03 209 944716 36934 109607440
Eosinophilic granulomatosis with polyangiitis 21.06 10.03 160 944765 10526 109633848
Intracranial pressure increased 21.03 10.03 36 944889 10499 109633875
Long QT syndrome 20.91 10.03 18 944907 7100 109637274
Ileus paralytic 20.87 10.03 43 944882 11694 109632680
Pseudomonal sepsis 20.86 10.03 28 944897 9018 109635356
Laryngospasm 20.71 10.03 7 944918 4661 109639713
Capillary leak syndrome 20.68 10.03 8 944917 4900 109639474
Liver disorder 20.64 10.03 1446 943479 140797 109503577
Metastases to lymph nodes 20.57 10.03 63 944862 14969 109629405
Frequent bowel movements 20.56 10.03 775 944150 70615 109573759
Chills 20.52 10.03 1377 943548 189203 109455171
Methaemoglobinaemia 20.52 10.03 29 944896 9139 109635235
Cystitis 20.51 10.03 723 944202 65313 109579061
Gastroenteritis viral 20.50 10.03 378 944547 30848 109613526
Bone marrow failure 20.49 10.03 359 944566 57489 109586885
Nicotine dependence 20.44 10.03 39 944886 1292 109643082
Osteonecrosis of jaw 20.37 10.03 288 944637 47729 109596645
Euglycaemic diabetic ketoacidosis 20.32 10.03 43 944882 11580 109632794
Brain injury 20.26 10.03 54 944871 13422 109630952
Cleft lip and palate 20.22 10.03 28 944897 704 109643670
Heparin-induced thrombocytopenia 20.19 10.03 42 944883 11382 109632992
Infection reactivation 20.16 10.03 5 944920 4076 109640298
Depressed mood 20.09 10.03 382 944543 60427 109583947
Total lung capacity abnormal 20.04 10.03 85 944840 4498 109639876
Transplant dysfunction 20.01 10.03 25 944900 8303 109636071
Hypertensive crisis 19.96 10.03 124 944801 24248 109620126
Epstein-Barr virus associated lymphoproliferative disorder 19.95 10.03 8 944917 4794 109639580
Bacterial infection 19.93 10.03 275 944650 45761 109598613
Cholangitis 19.92 10.03 72 944853 16263 109628111
Product label confusion 19.91 10.03 288 944637 22389 109621985
Polyomavirus viraemia 19.81 10.03 3 944922 3471 109640903
Bone density decreased 19.76 10.03 217 944708 15825 109628549
Rheumatoid lung 19.74 10.03 81 944844 4223 109640151
Mite allergy 19.74 10.03 100 944825 5703 109638671
Synovial fluid analysis 19.73 10.03 59 944866 2622 109641752
Vertigo 19.70 10.03 578 944347 86292 109558082
Injection site erythema 19.68 10.03 989 943936 93187 109551187
Ankle arthroplasty 19.59 10.03 57 944868 2494 109641880
Skin ulcer 19.56 10.03 696 944229 62949 109581425
Neck pain 19.52 10.03 1261 943664 121869 109522505
Cataract 19.45 10.03 848 944077 78637 109565737
Therapeutic product effect incomplete 19.43 10.03 2191 942734 221614 109422760
Rib deformity 19.40 10.03 16 944909 216 109644158
Lip swelling 19.39 10.03 310 944615 50357 109594017
Intervertebral disc degeneration 19.32 10.03 238 944687 17847 109626527
Incoherent 19.15 10.03 26 944899 8332 109636042
Salivary gland calculus 19.14 10.03 18 944907 292 109644082
Laryngeal oedema 19.13 10.03 34 944891 9773 109634601
Drug screen positive 19.08 10.03 16 944909 6394 109637980
Systemic candida 19.08 10.03 35 944890 9939 109634435
Granuloma skin 19.01 10.03 163 944762 11120 109633254
Hypophosphataemic osteomalacia 19.00 10.03 21 944904 416 109643958
Full blood count abnormal 19.00 10.03 620 944305 55432 109588942
Stress fracture 18.93 10.03 116 944809 7105 109637269
Hepatic cancer 18.90 10.03 42 944883 11114 109633260
Airway remodelling 18.85 10.03 31 944894 911 109643463
Hydrops foetalis 18.83 10.03 28 944897 753 109643621
Hepatic necrosis 18.82 10.03 35 944890 9887 109634487
Ventricular arrhythmia 18.76 10.03 36 944889 10051 109634323
Injection site pruritus 18.70 10.03 572 944353 50686 109593688
Loose body in joint 18.67 10.03 39 944886 1381 109642993
Nasal obstruction 18.61 10.03 67 944858 3283 109641091
Lethargy 18.48 10.03 634 944291 92942 109551432
Incorrect dose administered 18.48 10.03 711 944214 102930 109541444
Epstein-Barr viraemia 18.45 10.03 4 944921 3575 109640799
Sinus disorder 18.39 10.03 387 944538 32341 109612033
Arterial occlusive disease 18.37 10.03 206 944719 15102 109629272
Diabetes mellitus 18.33 10.03 679 944246 98702 109545672
Nail operation 18.29 10.03 43 944882 1651 109642723
Tenosynovitis stenosans 18.29 10.03 70 944855 3533 109640841
Atrioventricular block 18.27 10.03 78 944847 16799 109627575
Arteriospasm coronary 18.25 10.03 31 944894 9069 109635305
Genital haemorrhage 18.24 10.03 21 944904 7231 109637143
Skin papilloma 18.22 10.03 111 944814 6785 109637589
Pneumothorax 18.20 10.03 203 944722 35082 109609292
Hepatitis B 18.15 10.03 34 944891 9578 109634796
Ventricular extrasystoles 18.13 10.03 116 944809 22525 109621849
Ultrasound antenatal screen 18.02 10.03 26 944899 680 109643694
Spinal osteoarthritis 17.99 10.03 257 944668 19926 109624448
Mood altered 17.90 10.03 108 944817 21267 109623107
Bacterial sepsis 17.87 10.03 39 944886 10387 109633987
Personality disorder 17.87 10.03 178 944747 12659 109631715
Hypoxic-ischaemic encephalopathy 17.87 10.03 30 944895 8817 109635557
Joint injury 17.86 10.03 458 944467 39536 109604838
Ileus 17.81 10.03 172 944753 30557 109613817
Glomerular filtration rate decreased 17.68 10.03 160 944765 28796 109615578
Bronchitis 17.65 10.03 1565 943360 155467 109488907
Breast feeding 17.57 10.03 26 944899 696 109643678
Mucocutaneous ulceration 17.57 10.03 27 944898 748 109643626
Postoperative wound infection 17.57 10.03 209 944716 15544 109628830
Pericardial effusion 17.52 10.03 364 944561 56853 109587521
Corneal oedema 17.51 10.03 3 944922 3170 109641204
Left ventricular dysfunction 17.49 10.03 123 944802 23370 109621004
Hypoglycaemic coma 17.49 10.03 13 944912 5520 109638854
Amylase increased 17.46 10.03 52 944873 12467 109631907
Amyloid arthropathy 17.45 10.03 42 944883 1638 109642736
Pulmonary embolism 17.42 10.03 1586 943339 212888 109431486
Dust allergy 17.41 10.03 99 944826 5902 109638472
Polyuria 17.41 10.03 85 944840 17653 109626721
Personality change 17.38 10.03 43 944882 10959 109633415
Pneumonia fungal 17.36 10.03 66 944859 14688 109629686
Skin cancer 17.29 10.03 230 944695 17554 109626820
Haematocrit decreased 17.22 10.03 710 944215 65407 109578967
Blood parathyroid hormone increased 17.21 10.03 77 944848 4171 109640203
Blood lactic acid increased 17.20 10.03 73 944852 15748 109628626
Wrong product administered 17.18 10.03 43 944882 10917 109633457
Complication of device removal 17.17 10.03 9 944916 4611 109639763
Mycotic allergy 17.13 10.03 98 944827 5856 109638518
Obsessive-compulsive disorder 17.12 10.03 22 944903 7219 109637155
Dysarthria 17.06 10.03 568 944357 83553 109560821
Colitis microscopic 17.03 10.03 58 944867 13336 109631038
Gastric haemorrhage 16.96 10.03 74 944851 15841 109628533
Complication of device insertion 16.92 10.03 31 944894 8807 109635567
Normal newborn 16.88 10.03 272 944653 21624 109622750
Pain of skin 16.88 10.03 101 944824 19928 109624446
Dysphagia 16.84 10.03 1108 943817 152492 109491882
Jaundice cholestatic 16.82 10.03 195 944730 14413 109629961
Wound infection pseudomonas 16.75 10.03 52 944873 2359 109642015
Abortion incomplete 16.74 10.03 3 944922 3069 109641305
Toxic encephalopathy 16.67 10.03 70 944855 15144 109629230
Spondylitis 16.66 10.03 159 944766 11179 109633195
Epstein-Barr virus infection reactivation 16.65 10.03 7 944918 4077 109640297
Brain abscess 16.63 10.03 20 944905 6754 109637620
Acute lymphocytic leukaemia recurrent 16.56 10.03 15 944910 5772 109638602
Breast cancer female 16.53 10.03 53 944872 12415 109631959
Nasal polyps 16.47 10.03 179 944746 13021 109631353
Human antichimeric antibody positive 16.45 10.03 42 944883 1700 109642674
Catatonia 16.45 10.03 46 944879 11254 109633120
International normalised ratio increased 16.42 10.03 591 944334 86181 109558193
Respiratory tract congestion 16.42 10.03 362 944563 30495 109613879
Acute pulmonary oedema 16.36 10.03 82 944843 16914 109627460
Clonus 16.30 10.03 31 944894 8685 109635689
Porphyria acute 16.29 10.03 238 944687 18542 109625832
Troponin increased 16.26 10.03 169 944756 29597 109614777
Haemoglobin decreased 16.24 10.03 2393 942532 246334 109398040
Gangrene 16.17 10.03 212 944713 16129 109628245
Fractional exhaled nitric oxide increased 16.16 10.03 26 944899 750 109643624
Sputum purulent 16.13 10.03 44 944881 1854 109642520
Hospitalisation 16.11 10.03 1025 943900 141468 109502906
Hypertriglyceridaemia 16.09 10.03 77 944848 16077 109628297
Persecutory delusion 16.06 10.03 18 944907 6273 109638101
Hepatic cytolysis 16.06 10.03 353 944572 54700 109589674
Trisomy 18 16.04 10.03 23 944902 598 109643776
Intraocular pressure increased 16.03 10.03 44 944881 10832 109633542
Temperature intolerance 16.03 10.03 63 944862 13887 109630487
Mitochondrial toxicity 15.98 10.03 4 944921 3241 109641133
Enterococcal infection 15.97 10.03 105 944820 20261 109624113
Femoral hernia incarcerated 15.97 10.03 38 944887 1471 109642903
Liver function test increased 15.93 10.03 917 944008 87631 109556743
Ingrown hair 15.86 10.03 26 944899 762 109643612
Malignant melanoma 15.83 10.03 217 944708 16674 109627700
Cardiac murmur 15.77 10.03 297 944628 24331 109620043
Device related infection 15.73 10.03 240 944685 39279 109605095
Post-traumatic stress disorder 15.64 10.03 20 944905 6576 109637798
Pallor 15.64 10.03 365 944560 56102 109588272
Dizziness 15.58 10.03 5541 939384 692652 108951722
Type I hypersensitivity 15.56 10.03 19 944906 6374 109638000
Fracture nonunion 15.56 10.03 38 944887 1496 109642878
Atopy 15.53 10.03 32 944893 1122 109643252
Pulmonary function test abnormal 15.49 10.03 12 944913 4988 109639386
Arteriosclerosis coronary artery 15.44 10.03 301 944624 24817 109619557
Autonomic nervous system imbalance 15.35 10.03 16 944909 5764 109638610
Parvovirus B19 infection 15.30 10.03 3 944922 2878 109641496
Hydrocephalus 15.28 10.03 42 944883 10333 109634041
Leukoencephalopathy 15.27 10.03 35 944890 9160 109635214
Body mass index abnormal 15.26 10.03 28 944897 900 109643474
Pancreatic steatosis 15.25 10.03 42 944883 1780 109642594
Concomitant disease aggravated 15.16 10.03 80 944845 16284 109628090
Breast cancer stage II 15.15 10.03 323 944602 27052 109617322
Metabolic disorder 15.14 10.03 43 944882 10467 109633907
Cold sweat 15.13 10.03 118 944807 21913 109622461
Swollen tongue 15.13 10.03 396 944529 59966 109584408
Panic attack 15.13 10.03 166 944759 28774 109615600
Lymphatic fistula 15.12 10.03 37 944888 1458 109642916
Migraine 15.11 10.03 1682 943243 169970 109474404
Pruritus 15.08 10.03 4588 940337 576972 109067402
Peritoneal dialysis complication 15.07 10.03 52 944873 2494 109641880
Plasma cell myeloma recurrent 15.05 10.03 23 944902 7019 109637355
Wrong patient received product 15.05 10.03 21 944904 6653 109637721
Extradural haematoma 15.03 10.03 5 944920 3364 109641010
Oropharyngeal pain 15.02 10.03 1347 943578 133929 109510445
Anticholinergic syndrome 14.95 10.03 9 944916 4271 109640103
Metastasis 14.95 10.03 30 944895 8237 109636137
Tibia fracture 14.95 10.03 102 944823 6483 109637891
Vitamin D decreased 14.94 10.03 165 944760 12050 109632324
Liver abscess 14.94 10.03 27 944898 7712 109636662
Gait disturbance 14.92 10.03 2648 942277 275560 109368814
Walking aid user 14.91 10.03 299 944626 24776 109619598
Tension headache 14.87 10.03 38 944887 9580 109634794
Insurance issue 14.86 10.03 44 944881 10568 109633806
Product dose omission in error 14.76 10.03 129 944796 23383 109620991
Immune thrombocytopenia 14.75 10.03 122 944803 22372 109622002
Tooth disorder 14.70 10.03 343 944582 29166 109615208
Cystoid macular oedema 14.70 10.03 3 944922 2797 109641577
Pharyngeal swelling 14.69 10.03 53 944872 11979 109632395
Steroid diabetes 14.58 10.03 14 944911 5240 109639134
Areflexia 14.57 10.03 22 944903 6747 109637627
Placental disorder 14.56 10.03 29 944896 992 109643382
Vascular purpura 14.53 10.03 7 944918 3764 109640610
Anhedonia 14.53 10.03 75 944850 15353 109629021
Tumour haemorrhage 14.53 10.03 14 944911 5231 109639143
Lower respiratory tract congestion 14.50 10.03 80 944845 4716 109639658
Haemorrhagic transformation stroke 14.47 10.03 4 944921 3033 109641341
Short stature 14.46 10.03 30 944895 1057 109643317
Epidermal necrosis 14.46 10.03 58 944867 2992 109641382
Aspiration 14.46 10.03 179 944746 30354 109614020
Low turnover osteopathy 14.41 10.03 44 944881 1978 109642396
Maternal exposure during breast feeding 14.39 10.03 73 944852 4165 109640209
Infective pulmonary exacerbation of cystic fibrosis 14.37 10.03 71 944854 14700 109629674
Endodontic procedure 14.37 10.03 59 944866 3077 109641297
Renal tubular disorder 14.27 10.03 26 944899 7403 109636971
Immune-mediated hepatitis 14.27 10.03 22 944903 6689 109637685
Eyelid ptosis 14.18 10.03 62 944863 13265 109631109
Dysphonia 14.18 10.03 518 944407 75411 109568963
Osteoporotic fracture 14.16 10.03 86 944839 5251 109639123
Throat tightness 14.16 10.03 201 944724 33288 109611086
Hyperventilation 14.10 10.03 35 944890 8912 109635462
Sarcoidosis 14.08 10.03 167 944758 12412 109631962
Hypokinesia 14.03 10.03 119 944806 21707 109622667
Reversible cerebral vasoconstriction syndrome 14.03 10.03 12 944913 4749 109639625
Alcohol interaction 14.02 10.03 7 944918 3687 109640687
Aortic arteriosclerosis 13.96 10.03 149 944776 10789 109633585
Cyst 13.89 10.03 208 944717 16288 109628086
Aplasia 13.87 10.03 29 944896 7844 109636530
Accidental exposure to product by child 13.83 10.03 5 944920 3193 109641181
Bone density abnormal 13.80 10.03 68 944857 3835 109640539
Gastric cancer 13.77 10.03 48 944877 10960 109633414
Infusion site erythema 13.74 10.03 54 944871 11905 109632469
Immunisation 13.73 10.03 5 944920 3178 109641196
Panniculitis 13.72 10.03 198 944727 15384 109628990
Brain herniation 13.72 10.03 35 944890 8828 109635546
Renal cancer 13.65 10.03 61 944864 12973 109631401
Terminal state 13.63 10.03 17 944908 5650 109638724
Cardiac dysfunction 13.62 10.03 20 944905 6203 109638171
Body height below normal 13.61 10.03 44 944881 2040 109642334
Clostridium difficile colitis 13.56 10.03 278 944647 43500 109600874
Blood glucose decreased 13.55 10.03 174 944751 29314 109615060
Pseudomembranous colitis 13.54 10.03 21 944904 6370 109638004
Hypoparathyroidism 13.54 10.03 36 944889 1494 109642880
Small for dates baby 13.54 10.03 22 944903 640 109643734
Sudden death 13.53 10.03 138 944787 24257 109620117
Acute lung injury 13.51 10.03 5 944920 3146 109641228
Nystagmus 13.48 10.03 52 944873 11525 109632849
Oculogyric crisis 13.47 10.03 8 944917 3824 109640550
Cerebral toxoplasmosis 13.44 10.03 5 944920 3137 109641237
Rash morbilliform 13.42 10.03 30 944895 7921 109636453
Twin pregnancy 13.41 10.03 27 944898 931 109643443
Hyperlactacidaemia 13.39 10.03 32 944893 8254 109636120
Sleep apnoea syndrome 13.39 10.03 254 944671 40193 109604181
Loss of libido 13.38 10.03 5 944920 3128 109641246
Eyelid oedema 13.37 10.03 76 944849 15186 109629188
Pemphigoid 13.33 10.03 106 944819 19601 109624773
Neoplasm recurrence 13.33 10.03 15 944910 5217 109639157
Device issue 13.32 10.03 211 944714 34324 109610050
Cytomegalovirus colitis 13.31 10.03 25 944900 7036 109637338
Anal fissure 13.27 10.03 136 944789 9745 109634629
Pupillary reflex impaired 13.26 10.03 9 944916 4006 109640368
Product monitoring error 13.25 10.03 36 944889 8891 109635483
Drug abuser 13.25 10.03 16 944909 5393 109638981
Conjunctivitis allergic 13.23 10.03 103 944822 6828 109637546
Decreased appetite 13.23 10.03 3743 941182 472103 109172271
Unevaluable event 13.20 10.03 395 944530 58832 109585542
Hyporesponsive to stimuli 13.20 10.03 4 944921 2856 109641518
Urinary incontinence 13.19 10.03 315 944610 48272 109596102
Maternal exposure during delivery 13.17 10.03 7 944918 3558 109640816
Benign ovarian tumour 13.14 10.03 18 944907 448 109643926
Joint noise 13.10 10.03 82 944843 5061 109639313
Granulocyte count decreased 13.01 10.03 9 944916 3965 109640409
Antibody test positive 12.98 10.03 57 944868 3063 109641311
Pelvic fracture 12.92 10.03 181 944744 13973 109630401
Red blood cell count decreased 12.90 10.03 688 944237 65235 109579139
Asphyxia 12.89 10.03 70 944855 14145 109630229
Skin weeping 12.85 10.03 8 944917 3727 109640647
Post procedural infection 12.77 10.03 177 944748 13632 109630742
Hypertension 12.74 10.03 4695 940230 505389 109138985
Cerebral haematoma 12.73 10.03 41 944884 9591 109634783
Immune-mediated myocarditis 12.73 10.03 7 944918 3491 109640883
Skin burning sensation 12.72 10.03 122 944803 21703 109622671
Nail injury 12.70 10.03 24 944901 789 109643585
Ototoxicity 12.69 10.03 10 944915 4121 109640253
Extra dose administered 12.68 10.03 57 944868 12102 109632272
Oesophageal carcinoma 12.64 10.03 53 944872 11471 109632903
Brain death 12.63 10.03 23 944902 6550 109637824
Hypomagnesaemia 12.63 10.03 406 944519 59964 109584410
Lipodystrophy acquired 12.62 10.03 12 944913 4512 109639862
Foetal distress syndrome 12.56 10.03 21 944904 626 109643748
Quadriparesis 12.54 10.03 13 944912 4694 109639680
Lung opacity 12.53 10.03 54 944871 11598 109632776
Viraemia 12.51 10.03 10 944915 4092 109640282
Foot operation 12.51 10.03 106 944819 7207 109637167
Diaphragmatic disorder 12.48 10.03 40 944885 1846 109642528
Apnoea 12.45 10.03 67 944858 13572 109630802
Acquired gene mutation 12.44 10.03 4 944921 2750 109641624
Hypercapnia 12.44 10.03 51 944874 11108 109633266
Blood folate increased 12.40 10.03 20 944905 578 109643796
Dysuria 12.38 10.03 406 944519 59825 109584549
Toothache 12.36 10.03 276 944649 23299 109621075
Lymph gland infection 12.32 10.03 21 944904 636 109643738
Treatment noncompliance 12.30 10.03 504 944421 72486 109571888
Tooth fracture 12.27 10.03 169 944756 12998 109631376
Hyperthyroidism 12.24 10.03 176 944749 29085 109615289
Prerenal failure 12.24 10.03 12 944913 4447 109639927
Extravascular haemolysis 12.23 10.03 17 944908 429 109643945
Pneumomediastinum 12.22 10.03 15 944910 5021 109639353
Head injury 12.21 10.03 277 944648 42740 109601634
Fibroadenoma of breast 12.21 10.03 22 944903 697 109643677
Urine ketone body present 12.21 10.03 9 944916 3837 109640537
Atypical femur fracture 12.19 10.03 93 944832 6126 109638248
Polydipsia 12.18 10.03 30 944895 7658 109636716
Retinal haemorrhage 12.17 10.03 41 944884 9460 109634914
Blood prolactin increased 12.16 10.03 13 944912 4629 109639745
Deep vein thrombosis 12.16 10.03 1029 943896 138858 109505516
Fear of injection 12.13 10.03 123 944802 8788 109635586
Device loosening 12.11 10.03 24 944901 818 109643556
Myocardial ischaemia 12.06 10.03 158 944767 26526 109617848
Defaecation disorder 12.05 10.03 24 944901 821 109643553
Bone fissure 12.01 10.03 20 944905 594 109643780
Pancreatic carcinoma 12.01 10.03 76 944849 14796 109629578
Drooling 11.99 10.03 27 944898 7112 109637262
Serositis 11.99 10.03 35 944890 1534 109642840
Appendicitis 11.98 10.03 171 944754 28293 109616081
Clear cell renal cell carcinoma 11.96 10.03 51 944874 2705 109641669
Fungaemia 11.96 10.03 21 944904 6065 109638309
Malaise 11.92 10.03 6113 938812 665706 108978668
Lipase increased 11.92 10.03 102 944823 18570 109625804
Foetal exposure during pregnancy 11.91 10.03 107 944818 7398 109636976
Hepatitis C 11.91 10.03 61 944864 12512 109631862
Heart rate irregular 11.85 10.03 380 944545 33894 109610480
Hypopituitarism 11.83 10.03 12 944913 4378 109639996
Facial paralysis 11.83 10.03 141 944784 24073 109620301
Embolism 11.78 10.03 86 944839 16203 109628171
Radiation inflammation 11.75 10.03 27 944898 1021 109643353
Coronary artery bypass 11.74 10.03 21 944904 6021 109638353
Pulmonary pain 11.72 10.03 93 944832 6200 109638174
Hypophagia 11.72 10.03 351 944574 52275 109592099
Lymphoedema 11.69 10.03 77 944848 14852 109629522
Hypoventilation 11.69 10.03 33 944892 8048 109636326
Affect lability 11.68 10.03 224 944701 18413 109625961
Induced labour 11.66 10.03 25 944900 902 109643472
Muscular weakness 11.65 10.03 2349 942576 246119 109398255
Alcohol abuse 11.63 10.03 15 944910 4914 109639460
Cushingoid 11.61 10.03 152 944773 11560 109632814
Sickle cell anaemia 11.60 10.03 23 944902 784 109643590
Haematuria 11.59 10.03 585 944340 82420 109561954
Bone density increased 11.57 10.03 26 944899 969 109643405
Device occlusion 11.55 10.03 79 944846 15106 109629268
Poor quality device used 11.52 10.03 5 944920 2858 109641516
Paronychia 11.52 10.03 52 944873 11029 109633345
Carbuncle 11.48 10.03 33 944892 1434 109642940
Cyst rupture 11.47 10.03 24 944901 851 109643523
Drug eruption 11.43 10.03 360 944565 53299 109591075
Dysgeusia 11.42 10.03 485 944440 69500 109574874
Vasoplegia syndrome 11.40 10.03 18 944907 5421 109638953
Skin fissures 11.35 10.03 144 944781 24314 109620060
Pancreatic duct rupture 11.31 10.03 3 944922 0 109644374
Device breakage 11.31 10.03 70 944855 13699 109630675
Choking 11.30 10.03 79 944846 15031 109629343
Labyrinthitis 11.29 10.03 54 944871 3008 109641366
Hypoproteinaemia 11.25 10.03 21 944904 5924 109638450
Pain in jaw 11.23 10.03 342 944583 50835 109593539
Ulcer 11.23 10.03 463 944462 42653 109601721
Lacrimal disorder 11.22 10.03 18 944907 518 109643856
Infusion site pain 11.19 10.03 95 944830 17324 109627050
Catheter site pain 11.14 10.03 24 944901 6422 109637952
Prostatic specific antigen increased 11.13 10.03 62 944863 12449 109631925
Hepatic siderosis 11.11 10.03 10 944915 153 109644221
Coronary arterial stent insertion 11.10 10.03 21 944904 5894 109638480
Subileus 11.10 10.03 24 944901 6413 109637961
Hypovolaemic shock 11.03 10.03 76 944849 14507 109629867
Lip oedema 11.02 10.03 31 944894 7569 109636805
Metastases to skin 11.01 10.03 3 944922 2296 109642078
Spinal cord injury lumbar 11.00 10.03 7 944918 61 109644313
Placental insufficiency 11.00 10.03 30 944895 1264 109643110
Neurological symptom 10.97 10.03 191 944734 15417 109628957
Middle insomnia 10.96 10.03 117 944808 20385 109623989
Device malfunction 10.95 10.03 153 944772 25405 109618969
Cervical incompetence 10.95 10.03 18 944907 529 109643845
Pulmonary calcification 10.95 10.03 18 944907 529 109643845
Ataxia 10.93 10.03 186 944739 29922 109614452
Fixed eruption 10.92 10.03 12 944913 4220 109640154
Cardiopulmonary failure 10.90 10.03 33 944892 7870 109636504
Supraventricular tachycardia 10.89 10.03 145 944780 24277 109620097
Pancreatitis 10.89 10.03 671 944254 92862 109551512
Sensory loss 10.87 10.03 250 944675 21207 109623167
Dysmorphism 10.87 10.03 20 944905 644 109643730
Stillbirth 10.87 10.03 68 944857 4196 109640178
Injection site warmth 10.84 10.03 209 944716 17196 109627178
Ulcer haemorrhage 10.83 10.03 261 944664 22310 109622064
Palpitations 10.76 10.03 1193 943732 158019 109486355
Multimorbidity 10.76 10.03 33 944892 1487 109642887
Vaccination site oedema 10.76 10.03 4 944921 8 109644366
Cholestatic liver injury 10.76 10.03 30 944895 7346 109637028
Anaesthetic complication 10.74 10.03 9 944916 3597 109640777
Viral haemorrhagic cystitis 10.73 10.03 8 944917 3391 109640983
Lymphadenopathy 10.71 10.03 441 944484 63394 109580980
Vertebral osteophyte 10.70 10.03 18 944907 539 109643835
Hypophosphatasia 10.70 10.03 9 944916 125 109644249
Hyperlipidaemia 10.70 10.03 229 944696 35619 109608755
Haemorrhage in pregnancy 10.70 10.03 35 944890 1633 109642741
Accident at work 10.65 10.03 29 944896 1221 109643153
Pneumonia viral 10.64 10.03 54 944871 11103 109633271
N-telopeptide urine increased 10.63 10.03 6 944919 41 109644333
Mental impairment 10.62 10.03 133 944792 22506 109621868
Product administration interrupted 10.57 10.03 55 944870 11237 109633137
Accidental poisoning 10.57 10.03 4 944921 2483 109641891
Dyspnoea exertional 10.52 10.03 756 944169 103304 109541070
Eye movement disorder 10.51 10.03 45 944880 9683 109634691
Radiation pneumonitis 10.50 10.03 14 944911 4522 109639852
Nephrotic syndrome 10.50 10.03 72 944853 13759 109630615
Klebsiella sepsis 10.48 10.03 12 944913 4141 109640233
Pancytopenia 10.48 10.03 1988 942937 207625 109436749
Osteomyelitis 10.46 10.03 397 944528 36203 109608171
Thinking abnormal 10.44 10.03 81 944844 15059 109629315
Presyncope 10.41 10.03 328 944597 48559 109595815
Delayed recovery from anaesthesia 10.40 10.03 3 944922 2212 109642162
Schizoaffective disorder 10.40 10.03 7 944918 3129 109641245
Breast cancer in situ 10.37 10.03 28 944897 1173 109643201
Anger 10.35 10.03 108 944817 18899 109625475
Hereditary angioedema 10.32 10.03 29 944896 7085 109637289
Kounis syndrome 10.29 10.03 22 944903 5903 109638471
Human anti-human antibody test 10.29 10.03 15 944910 396 109643978
Troponin T increased 10.27 10.03 13 944912 4293 109640081
Liver transplant rejection 10.24 10.03 11 944914 3907 109640467
Post procedural haemorrhage 10.23 10.03 84 944841 15428 109628946
Gambling disorder 10.23 10.03 3 944922 2188 109642186
Erythema of eyelid 10.22 10.03 11 944914 3904 109640470
Mitral valve incompetence 10.22 10.03 212 944713 33117 109611257
Depersonalisation/derealisation disorder 10.16 10.03 3 944922 2178 109642196
Inflammatory marker increased 10.15 10.03 177 944748 14292 109630082
Staphylococcal infection 10.14 10.03 491 944434 69453 109574921
Disorganised speech 10.14 10.03 8 944917 3295 109641079
Wrong technique in device usage process 10.11 10.03 28 944897 6873 109637501
Infusion site pruritus 10.10 10.03 17 944908 4991 109639383
Tender joint count increased 10.10 10.03 15 944910 403 109643971
Cogwheel rigidity 10.09 10.03 10 944915 3688 109640686
Swollen joint count 10.08 10.03 116 944809 8558 109635816
International normalised ratio fluctuation 10.06 10.03 12 944913 4068 109640306
Back disorder 10.06 10.03 242 944683 20680 109623694
Cardiovascular insufficiency 10.05 10.03 8 944917 3280 109641094

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A02AC01 ALIMENTARY TRACT AND METABOLISM
DRUGS FOR ACID RELATED DISORDERS
ANTACIDS
Calcium compounds
ATC A12AA04 ALIMENTARY TRACT AND METABOLISM
MINERAL SUPPLEMENTS
CALCIUM
Calcium
CHEBI has role CHEBI:33287 fertilizer
CHEBI has role CHEBI:35526 hypoglycemic agent
CHEBI has role CHEBI:35610 antineoplastic agent
CHEBI has role CHEBI:38070 anti-arrhythmia drug
CHEBI has role CHEBI:50646 bone density conservation agent
CHEBI has role CHEBI:62868 hepatoprotective agent
CHEBI has role CHEBI:64946 anti-HIV agent
CHEBI has role CHEBI:65265 antacid
CHEBI has role CHEBI:74518 anti-obesity agent
CHEBI has role CHEBI:75835 anti-anaemic agent
CHEBI has role CHEBI:77182 food colouring
CHEBI has role CHEBI:77960 food firming agent
CHEBI has role CHEBI:176497 geroprotector
MeSH PA D000863 Antacids
MeSH PA D005765 Gastrointestinal Agents

Related Drugs by ATC class:

A02AC Calcium compounds 1 drug
calcium silicate
A12AA Calcium 11 drugs
calcium chloridecalcium citratecalcium glubionatecalcium glucoheptonatecalcium gluconatecalcium glycerylphosphatecalcium lactatecalcium lactate gluconatecalcium levulinatecalcium pangamatecalcium phosphate

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Hypocalcemia indication 5291005
Indigestion indication 162031009
Heartburn Prevention indication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
H0G9379FGK UNII
4019035 VUID
N0000147306 NUI
4017644 VANDF
4019033 VANDF
4019035 VANDF
C0006681 UMLSCUI
CHEBI:3311 CHEBI
CHEMBL1200539 ChEMBL_ID
10112 PUBCHEM_CID
DB06724 DRUGBANK_ID
D002119 MESH_DESCRIPTOR_UI
1897 RXNORM
10153 MMSL
32787 MMSL
41410 MMSL
4326 MMSL
4330 MMSL
6070 MMSL
d00425 MMSL
000773 NDDF
001117 NDDF
387307005 SNOMEDCT_US
55217007 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Gas-X Total Relief Maximum Strength HUMAN OTC DRUG LABEL 2 0067-0118 TABLET, CHEWABLE 750 mg ORAL OTC Monograph Drug 14 sections
Gas-X Total Relief Maximum Strength HUMAN OTC DRUG LABEL 2 0067-0118 TABLET, CHEWABLE 750 mg ORAL OTC Monograph Drug 14 sections
Gas-X Total Relief Maximum Strength HUMAN OTC DRUG LABEL 2 0067-0119 TABLET, CHEWABLE 750 mg ORAL OTC Monograph Drug 14 sections
Gas-X Total Relief Maximum Strength HUMAN OTC DRUG LABEL 2 0067-0119 TABLET, CHEWABLE 750 mg ORAL OTC Monograph Drug 14 sections
Good Sense Dual Action Complete HUMAN OTC DRUG LABEL 3 0113-0032 TABLET, CHEWABLE 800 mg ORAL ANDA 15 sections
Good Sense Dual Action Complete HUMAN OTC DRUG LABEL 3 0113-0032 TABLET, CHEWABLE 800 mg ORAL ANDA 15 sections
injoy heartburn relief HUMAN OTC DRUG LABEL 3 0113-6023 TABLET, CHEWABLE 800 mg ORAL ANDA 15 sections
injoy heartburn relief HUMAN OTC DRUG LABEL 3 0113-6023 TABLET, CHEWABLE 800 mg ORAL ANDA 15 sections
GOOD SENSE DUAL ACTION COMPLETE HUMAN OTC DRUG LABEL 3 0113-7050 TABLET, CHEWABLE 800 mg ORAL ANDA 15 sections
GOOD SENSE DUAL ACTION COMPLETE HUMAN OTC DRUG LABEL 3 0113-7050 TABLET, CHEWABLE 800 mg ORAL ANDA 15 sections
Calcium Carbonate HUMAN OTC DRUG LABEL 1 0121-0766 SUSPENSION 1250 mg ORAL OTC Monograph Drug 13 sections
Calcium Carbonate HUMAN OTC DRUG LABEL 1 0121-0766 SUSPENSION 1250 mg ORAL OTC Monograph Drug 13 sections
Calcium Carbonate HUMAN OTC DRUG LABEL 1 0121-4766 SUSPENSION 1250 mg ORAL OTC Monograph Drug 13 sections
Calcium Carbonate HUMAN OTC DRUG LABEL 1 0121-4766 SUSPENSION 1250 mg ORAL OTC Monograph Drug 13 sections
TUMS HUMAN OTC DRUG LABEL 1 0135-0070 TABLET 500 mg ORAL OTC Monograph Drug 12 sections
TUMS HUMAN OTC DRUG LABEL 1 0135-0070 TABLET 500 mg ORAL OTC Monograph Drug 12 sections
TUMS HUMAN OTC DRUG LABEL 1 0135-0071 TABLET 500 mg ORAL OTC Monograph Drug 12 sections
TUMS HUMAN OTC DRUG LABEL 1 0135-0071 TABLET 500 mg ORAL OTC Monograph Drug 12 sections
TUMSEX HUMAN OTC DRUG LABEL 1 0135-0074 TABLET 750 mg ORAL OTC Monograph Drug 12 sections
TUMSEX HUMAN OTC DRUG LABEL 1 0135-0074 TABLET 750 mg ORAL OTC Monograph Drug 12 sections
TUMSEX HUMAN OTC DRUG LABEL 1 0135-0076 TABLET 750 mg ORAL OTC Monograph Drug 12 sections
TUMSEX HUMAN OTC DRUG LABEL 1 0135-0076 TABLET 750 mg ORAL OTC Monograph Drug 12 sections
TUMS ULTRA HUMAN OTC DRUG LABEL 1 0135-0118 TABLET, CHEWABLE 1000 mg ORAL OTC Monograph Drug 12 sections
TUMS ULTRA HUMAN OTC DRUG LABEL 1 0135-0118 TABLET, CHEWABLE 1000 mg ORAL OTC Monograph Drug 12 sections
Tums Chewy Bites Mixed Fruit HUMAN OTC DRUG LABEL 1 0135-0138 TABLET, CHEWABLE 1000 mg ORAL OTC Monograph Drug 12 sections
Tums Chewy Bites Mixed Fruit HUMAN OTC DRUG LABEL 1 0135-0138 TABLET, CHEWABLE 1000 mg ORAL OTC Monograph Drug 12 sections
TUMSEX HUMAN OTC DRUG LABEL 1 0135-0140 TABLET 750 mg ORAL OTC Monograph Drug 12 sections
TUMSEX HUMAN OTC DRUG LABEL 1 0135-0140 TABLET 750 mg ORAL OTC Monograph Drug 12 sections
TUMSEX HUMAN OTC DRUG LABEL 1 0135-0154 TABLET 750 mg ORAL OTC Monograph Drug 12 sections
TUMSEX HUMAN OTC DRUG LABEL 1 0135-0154 TABLET 750 mg ORAL OTC Monograph Drug 12 sections