nitrous oxide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4238 10024-97-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • nitrous oxide
  • dinitrogen monoxide
  • dinitrogen oxide
  • nitrous oxide, usp
Nitrogen oxide (N2O). A colorless, odorless gas that is used as an anesthetic and analgesic. High concentrations cause a narcotic effect and may replace oxygen, causing death by asphyxia. It is also used as a food aerosol in the preparation of whipping cream.
  • Molecular weight: 44.01
  • Formula: N2O
  • CLOGP: -0.90
  • LIPINSKI: None
  • HAC: 3
  • HDO: 0
  • TPSA: 54.46
  • ALOGS:
  • ROTB: 0

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Choroidal infarction 142.29 45.45 18 1816 67 63487121
Subacute combined cord degeneration 140.31 45.45 20 1814 210 63486978
Hyperthermia malignant 101.21 45.45 18 1816 816 63486372
Leukoencephalopathy 91.58 45.45 22 1812 4391 63482797
Lipodystrophy acquired 85.20 45.45 17 1817 1435 63485753
Drug interaction 84.17 45.45 62 1772 229069 63258119
Cardiac arrest 82.38 45.45 44 1790 92501 63394687
Bladder agenesis 66.89 45.45 10 1824 149 63487039
Genitalia external ambiguous 66.46 45.45 10 1824 156 63487032
Cloacal exstrophy 66.46 45.45 10 1824 156 63487032
Meconium stain 64.55 45.45 10 1824 191 63486997
Congenital ectopic bladder 62.81 45.45 9 1825 98 63487090
Disinhibition 61.91 45.45 12 1822 871 63486317
Tethered cord syndrome 61.09 45.45 10 1824 274 63486914
Gastrointestinal disorder congenital 60.14 45.45 9 1825 135 63487053
Congenital genital malformation 59.42 45.45 9 1825 147 63487041
Caudal regression syndrome 58.29 45.45 9 1825 168 63487020
Gastrointestinal malformation 57.74 45.45 9 1825 179 63487009
Anal atresia 57.72 45.45 10 1824 388 63486800
Epilepsy with myoclonic-atonic seizures 54.45 45.45 8 1826 105 63487083
Meningomyelocele 53.33 45.45 10 1824 608 63486580
Umbilical cord abnormality 52.63 45.45 10 1824 653 63486535
Brain oedema 50.57 45.45 18 1816 14177 63473011
Neural tube defect 49.81 45.45 8 1826 194 63486994
Vitamin B12 deficiency 49.42 45.45 14 1820 5289 63481899
Exomphalos 47.98 45.45 9 1825 548 63486640
Apnoea 47.85 45.45 15 1819 8007 63479181
Anencephaly 46.46 45.45 8 1826 299 63486889

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Subacute combined cord degeneration 330.61 40.80 43 1645 109 34955134
Choroidal infarction 139.36 40.80 19 1669 76 34955167
Myelopathy 87.61 40.80 21 1667 2476 34952767
Hyperthermia malignant 79.96 40.80 19 1669 2158 34953085
Vitamin B12 deficiency 72.96 40.80 20 1668 4011 34951232
Anaesthetic complication 69.50 40.80 15 1673 1105 34954138
Laryngospasm 49.27 40.80 12 1676 1509 34953734
Drug use disorder 45.57 40.80 14 1674 4177 34951066
Drug abuse 43.78 40.80 37 1651 99059 34856184
Bradycardia 41.43 40.80 32 1656 75386 34879857

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Subacute combined cord degeneration 432.45 34.22 59 3300 282 79740747
Choroidal infarction 276.64 34.22 37 3322 147 79740882
Hyperthermia malignant 140.71 34.22 31 3328 2886 79738143
Myelopathy 131.54 34.22 32 3327 4601 79736428
Vitamin B12 deficiency 122.03 34.22 33 3326 7208 79733821
Cardiac arrest 105.84 34.22 74 3285 172022 79569007
Anaesthetic complication 92.76 34.22 22 3337 2837 79738192
Drug interaction 72.43 34.22 88 3271 415095 79325934
Laryngospasm 71.02 34.22 19 3340 3978 79737051
Leukoencephalopathy 70.53 34.22 22 3337 7907 79733122
Bradycardia 64.49 34.22 50 3309 135507 79605522
Delayed recovery from anaesthesia 54.92 34.22 13 3346 1660 79739369
Epilepsy with myoclonic-atonic seizures 51.22 34.22 8 3351 108 79740921
Drug abuse 50.59 34.22 47 3312 162644 79578385
Neuromuscular block prolonged 49.95 34.22 11 3348 1019 79740010
Vitamin B12 decreased 49.91 34.22 14 3345 3491 79737538
Apnoea 47.30 34.22 18 3341 11686 79729343
Drug use disorder 44.91 34.22 16 3343 8635 79732394
Disinhibition 44.50 34.22 12 3347 2586 79738443
Neuromuscular blockade 44.22 34.22 9 3350 571 79740458
Ventricular tachycardia 43.10 34.22 25 3334 41910 79699119
Pulmonary oedema 40.72 34.22 32 3327 88222 79652807
Blood homocysteine increased 40.64 34.22 8 3351 428 79740601
Air embolism 40.44 34.22 8 3351 439 79740590
Substance use 39.95 34.22 9 3350 925 79740104
Change in seizure presentation 39.21 34.22 8 3351 514 79740515
Neuropathy vitamin B12 deficiency 37.89 34.22 6 3353 89 79740940
Brain oedema 36.88 34.22 19 3340 25244 79715785
Dystonia 36.84 34.22 18 3341 21381 79719648

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC N01AX13 NERVOUS SYSTEM
ANESTHETICS
ANESTHETICS, GENERAL
Other general anesthetics
ATC N01AX63 NERVOUS SYSTEM
ANESTHETICS
ANESTHETICS, GENERAL
Other general anesthetics
MeSH PA D000700 Analgesics
MeSH PA D018712 Analgesics, Non-Narcotic
MeSH PA D000777 Anesthetics
MeSH PA D018685 Anesthetics, Inhalation
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D018689 Sensory System Agents
CHEBI has role CHEBI:35620 vasodilator agents
CHEBI has role CHEBI:38869 general anaesthetic
CHEBI has role CHEBI:38870 inhalation anesthetics
CHEBI has role CHEBI:60643 N-methyl-D-aspartate receptor antagonists
CHEBI has role CHEBI:76413 greenhouse gases
CHEBI has role CHEBI:77971 food raising agent
CHEBI has role CHEBI:77974 food packaging gases
CHEBI has role CHEBI:78017 food propellants
CHEBI has role CHEBI:78433 refrigerants

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

ProductApplicantIngredients
None (Med Gas) Air Liquide America Specialty Gases 2
None (Med Gas) Nitrous Oxide Corp 2
None (Med Gas) Nitrous Oxide of Canada 2
None (Med Gas) Strata Medical Innovations 2
None (Med Gas) Praxair Mexico, S. de R.L. de C.V. 2

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
K50XQU1029 UNII
4019137 VUID
N0000147387 NUI
D00102 KEGG_DRUG
4019137 VANDF
C0028215 UMLSCUI
CHEBI:17045 CHEBI
N2O PDB_CHEM_ID
CHEMBL1234579 ChEMBL_ID
948 PUBCHEM_CID
DB06690 DRUGBANK_ID
D009609 MESH_DESCRIPTOR_UI
7486 RXNORM
d00934 MMSL
001387 NDDF
111132001 SNOMEDCT_US
388185005 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
NITROUS OXIDE HUMAN PRESCRIPTION DRUG LABEL 1 10006-002 GAS 99 L RESPIRATORY (INHALATION) unapproved medical gas 1 sections
Nitrous Oxide HUMAN PRESCRIPTION DRUG LABEL 1 10014-003 GAS 990 mL RESPIRATORY (INHALATION) NDA 1 sections
Nitrous Oxide HUMAN PRESCRIPTION DRUG LABEL 1 10014-003 GAS 990 mL RESPIRATORY (INHALATION) NDA 1 sections
NITROUS OXIDE HUMAN PRESCRIPTION DRUG LABEL 1 10167-200 GAS 99 L RESPIRATORY (INHALATION) NDA 1 sections
NITROUS OXIDE HUMAN PRESCRIPTION DRUG LABEL 1 10167-200 GAS 99 L RESPIRATORY (INHALATION) NDA 1 sections
Nitrous Oxide HUMAN PRESCRIPTION DRUG LABEL 1 10252-003 GAS 990 mL RESPIRATORY (INHALATION) NDA 1 sections
Nitrous Oxide HUMAN PRESCRIPTION DRUG LABEL 1 10252-003 GAS 990 mL RESPIRATORY (INHALATION) NDA 1 sections
Nitrous Oxide HUMAN PRESCRIPTION DRUG LABEL 1 10678-006 GAS 992 mL RESPIRATORY (INHALATION) unapproved medical gas 1 sections
Nitrous Oxide HUMAN PRESCRIPTION DRUG LABEL 1 10736-017 GAS 995 mL RESPIRATORY (INHALATION) NDA 1 sections
Nitrous Oxide HUMAN PRESCRIPTION DRUG LABEL 1 10736-017 GAS 995 mL RESPIRATORY (INHALATION) NDA 1 sections
NITROUS OXIDE HUMAN PRESCRIPTION DRUG LABEL 1 10927-102 GAS 99 L RESPIRATORY (INHALATION) NDA 1 sections
NITROUS OXIDE HUMAN PRESCRIPTION DRUG LABEL 1 11054-007 GAS 992 mL RESPIRATORY (INHALATION) NDA 1 sections
NITROUS OXIDE HUMAN PRESCRIPTION DRUG LABEL 1 11054-007 GAS 992 mL RESPIRATORY (INHALATION) NDA 1 sections
NITROUS OXIDE HUMAN PRESCRIPTION DRUG LABEL 1 11054-007 GAS 992 mL RESPIRATORY (INHALATION) NDA 1 sections
NITROUS OXIDE HUMAN PRESCRIPTION DRUG LABEL 1 12121-002 GAS 99 L RESPIRATORY (INHALATION) NDA 1 sections
NITROUS OXIDE HUMAN PRESCRIPTION DRUG LABEL 1 12121-002 GAS 99 L RESPIRATORY (INHALATION) NDA 1 sections
Nitrous Oxide HUMAN PRESCRIPTION DRUG LABEL 1 12213-593 GAS 990 mL RESPIRATORY (INHALATION) NDA 1 sections
Nitrous Oxide HUMAN PRESCRIPTION DRUG LABEL 1 12213-593 GAS 990 mL RESPIRATORY (INHALATION) NDA 1 sections
Nitrous Oxide HUMAN PRESCRIPTION DRUG LABEL 1 17575-011 GAS 990 mL RESPIRATORY (INHALATION) NDA 1 sections
Nitrous Oxide HUMAN PRESCRIPTION DRUG LABEL 1 17575-011 GAS 990 mL RESPIRATORY (INHALATION) NDA 1 sections
Nitrous Oxide HUMAN PRESCRIPTION DRUG LABEL 1 18482-002 GAS 995 mL RESPIRATORY (INHALATION) NDA 1 sections
Nitrous Oxide HUMAN PRESCRIPTION DRUG LABEL 1 18482-002 GAS 995 mL RESPIRATORY (INHALATION) NDA 1 sections
Nitrous Oxide HUMAN PRESCRIPTION DRUG LABEL 1 18482-128 GAS 995 mL RESPIRATORY (INHALATION) unapproved medical gas 1 sections
Nitrous Oxide HUMAN PRESCRIPTION DRUG LABEL 1 20703-003 GAS 990 mL RESPIRATORY (INHALATION) NDA 1 sections
Nitrous Oxide HUMAN PRESCRIPTION DRUG LABEL 1 20703-003 GAS 990 mL RESPIRATORY (INHALATION) NDA 1 sections
Nitrous Oxide HUMAN PRESCRIPTION DRUG LABEL 1 21220-122 GAS 995 mL RESPIRATORY (INHALATION) NDA 1 sections
Nitrous Oxide HUMAN PRESCRIPTION DRUG LABEL 1 21220-122 GAS 995 mL RESPIRATORY (INHALATION) NDA 1 sections
Nitrous Oxide HUMAN PRESCRIPTION DRUG LABEL 1 21220-122 GAS 995 mL RESPIRATORY (INHALATION) NDA 1 sections
NITROUS OXIDE HUMAN PRESCRIPTION DRUG LABEL 1 24312-003 GAS 99 L RESPIRATORY (INHALATION) NDA 1 sections
NITROUS OXIDE HUMAN PRESCRIPTION DRUG LABEL 1 24312-003 GAS 99 L RESPIRATORY (INHALATION) NDA 1 sections