nitrous oxide Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
4238 10024-97-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • nitrous oxide
  • dinitrogen monoxide
  • dinitrogen oxide
Nitrogen oxide (N2O). A colorless, odorless gas that is used as an anesthetic and analgesic. High concentrations cause a narcotic effect and may replace oxygen, causing death by asphyxia. It is also used as a food aerosol in the preparation of whipping cream.
  • Molecular weight: 44.01
  • Formula: N2O
  • CLOGP:
  • LIPINSKI: None
  • HAC: 3
  • HDO: 0
  • TPSA: 54.46
  • ALOGS:
  • ROTB: 0

Drug dosage:

None

ADMET properties:

None

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Choroidal infarction 167.40 111.95 17 158 17 2357893
Subacute combined cord degeneration 119.59 111.95 12 163 9 2357901

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Subacute combined cord degeneration 199.56 130.74 21 182 10 1746568
Choroidal infarction 154.77 130.74 17 186 20 1746558

Pharmacologic Action:

SourceCodeDescription
ATC N01AX13 NERVOUS SYSTEM
ANESTHETICS
ANESTHETICS, GENERAL
Other general anesthetics
ATC N01AX63 NERVOUS SYSTEM
ANESTHETICS
ANESTHETICS, GENERAL
Other general anesthetics
CHEBI has role CHEBI:38869 general anaesthetic
CHEBI has role CHEBI:35620 vasodilator agent
CHEBI has role CHEBI:35480 analgesic
CHEBI has role CHEBI:77974 food packaging gas
CHEBI has role CHEBI:78433 refrigerant
CHEBI has role CHEBI:77971 raising agent
CHEBI has role CHEBI:78017 food propellant
CHEBI has role CHEBI:38870 inhalation anaesthetic
MeSH PA D000700 Analgesics
MeSH PA D018712 Analgesics, Non-Narcotic
MeSH PA D000777 Anesthetics
MeSH PA D018685 Anesthetics, Inhalation
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D018689 Sensory System Agents

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
4019137 VUID
N0000147387 NUI
C0028215 UMLSCUI
D00102 KEGG_DRUG
388185005 SNOMEDCT_US
111132001 SNOMEDCT_US
4019137 VANDF
7486 RXNORM
d00934 MMSL
001387 NDDF
948 PUBCHEM_CID
CHEBI:17045 CHEBI
K50XQU1029 UNII
N2O PDB_CHEM_ID
DB06690 DRUGBANK_ID
CHEMBL1234579 ChEMBL_ID
D009609 MESH_DESCRIPTOR_UI

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
NITROUS OXIDE HUMAN PRESCRIPTION DRUG LABEL 1 10006-002 GAS 99 L RESPIRATORY (INHALATION) unapproved medical gas 1 sections
Nitrous Oxide HUMAN PRESCRIPTION DRUG LABEL 1 10014-003 GAS 990 mL RESPIRATORY (INHALATION) NDA 1 sections
NITROUS OXIDE HUMAN PRESCRIPTION DRUG LABEL 1 10167-200 GAS 99 L RESPIRATORY (INHALATION) NDA 1 sections
Nitrous Oxide HUMAN PRESCRIPTION DRUG LABEL 1 10252-003 GAS 990 mL RESPIRATORY (INHALATION) NDA 1 sections
Nitrous Oxide HUMAN PRESCRIPTION DRUG LABEL 1 10678-006 GAS 992 mL RESPIRATORY (INHALATION) unapproved medical gas 1 sections
Nitrous Oxide HUMAN PRESCRIPTION DRUG LABEL 1 10736-017 GAS 995 mL RESPIRATORY (INHALATION) NDA 1 sections
NITROUS OXIDE HUMAN PRESCRIPTION DRUG LABEL 1 10927-102 GAS 99 L RESPIRATORY (INHALATION) NDA 1 sections
NITROUS OXIDE HUMAN PRESCRIPTION DRUG LABEL 1 11054-007 GAS 992 mL RESPIRATORY (INHALATION) NDA 1 sections
NITROUS OXIDE HUMAN PRESCRIPTION DRUG LABEL 1 12121-002 GAS 99 L RESPIRATORY (INHALATION) NDA 1 sections
Nitrous Oxide HUMAN PRESCRIPTION DRUG LABEL 1 12213-593 GAS 990 mL RESPIRATORY (INHALATION) NDA 1 sections
Nitrous Oxide HUMAN PRESCRIPTION DRUG LABEL 1 17575-011 GAS 990 mL RESPIRATORY (INHALATION) NDA 1 sections
Nitrous Oxide HUMAN PRESCRIPTION DRUG LABEL 1 18482-002 GAS 995 mL RESPIRATORY (INHALATION) NDA 1 sections
Nitrous Oxide HUMAN PRESCRIPTION DRUG LABEL 1 18482-128 GAS 995 mL RESPIRATORY (INHALATION) unapproved medical gas 1 sections
Nitrous Oxide HUMAN PRESCRIPTION DRUG LABEL 1 20703-003 GAS 990 mL RESPIRATORY (INHALATION) NDA 1 sections
Nitrous Oxide HUMAN PRESCRIPTION DRUG LABEL 1 21220-122 GAS 995 mL RESPIRATORY (INHALATION) NDA 1 sections
NITROUS OXIDE HUMAN PRESCRIPTION DRUG LABEL 1 24312-003 GAS 99 L RESPIRATORY (INHALATION) NDA 1 sections
Nitrous Oxide HUMAN PRESCRIPTION DRUG LABEL 1 25373-003 GAS 99 L RESPIRATORY (INHALATION) unapproved medical gas 1 sections
Nitrous Oxide HUMAN PRESCRIPTION DRUG LABEL 1 25373-103 GAS 99 L RESPIRATORY (INHALATION) unapproved medical gas 2 sections
Nitrous Oxide Sedara HUMAN PRESCRIPTION DRUG LABEL 1 25373-703 GAS 990 mL RESPIRATORY (INHALATION) unapproved medical gas 2 sections
Nitrous Oxide HUMAN PRESCRIPTION DRUG LABEL 1 25543-012 GAS 990 mL RESPIRATORY (INHALATION) unapproved medical gas 1 sections
Nitrous Oxide HUMAN PRESCRIPTION DRUG LABEL 1 33344-003 GAS 99 L RESPIRATORY (INHALATION) unapproved medical gas 1 sections
Nitrous Oxide HUMAN PRESCRIPTION DRUG LABEL 1 33344-004 LIQUID 99 L RESPIRATORY (INHALATION) unapproved medical gas 1 sections
Nitrous Oxide HUMAN PRESCRIPTION DRUG LABEL 1 34057-010 GAS 990 mL RESPIRATORY (INHALATION) NDA 1 sections
NITROUS OXIDE HUMAN PRESCRIPTION DRUG LABEL 1 34330-003 GAS 99 L RESPIRATORY (INHALATION) unapproved medical gas 2 sections
NITROUS OXIDE HUMAN PRESCRIPTION DRUG LABEL 1 42602-003 GAS 99 L RESPIRATORY (INHALATION) NDA 1 sections
Nitrous Oxide HUMAN PRESCRIPTION DRUG LABEL 1 42751-1070 GAS 99 L RESPIRATORY (INHALATION) unapproved medical gas 1 sections
Nitrous Oxide HUMAN PRESCRIPTION DRUG LABEL 1 43621-003 GAS 990 mL RESPIRATORY (INHALATION) NDA 1 sections
Nitrous Oxide HUMAN PRESCRIPTION DRUG LABEL 1 44076-012 GAS 990 mL RESPIRATORY (INHALATION) NDA 1 sections
NITROUS OXIDE HUMAN PRESCRIPTION DRUG LABEL 1 44397-010 GAS 99 L RESPIRATORY (INHALATION) unapproved medical gas 2 sections
NITROUS OXIDE HUMAN PRESCRIPTION DRUG LABEL 1 44397-021 GAS 99 L RESPIRATORY (INHALATION) NDA 1 sections