vincamine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
vinca alkaloids 3643 1617-90-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • vincamine
  • vincadar
  • pervincamine
A major alkaloid of Vinca minor L., Apocynaceae. It has been used therapeutically as a vasodilator and antihypertensive agent, particularly in cerebrovascular disorders.
  • Molecular weight: 354.45
  • Formula: C21H26N2O3
  • CLOGP: 3.16
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 1
  • TPSA: 54.70
  • ALOGS: -3.21
  • ROTB: 3

Drug dosage:

None

ADMET properties:

PropertyValueReference
BA (Bioavailability) 20 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC C04AX07 CARDIOVASCULAR SYSTEM
PERIPHERAL VASODILATORS
PERIPHERAL VASODILATORS
Other peripheral vasodilators
MeSH PA D000959 Antihypertensive Agents
MeSH PA D002317 Cardiovascular Agents
CHEBI has role CHEBI:35674 antihypertensive agent
CHEBI has role CHEBI:35620 vasodilator agent
MeSH PA D014665 Vasodilator Agents

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Intracranial hemorrhage contraindication 1386000
Blood coagulation disorder contraindication 64779008 DOID:1247
Qualitative platelet disorder contraindication 267532001
Cerebral hemorrhage contraindication 274100004

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 7.67 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Muscarinic acetylcholine receptor M3 GPCR ALLOSTERIC MODULATOR Kd 5.70 IUPHAR
Muscarinic acetylcholine receptor M2 GPCR ALLOSTERIC MODULATOR Kd 5.10 IUPHAR
Muscarinic acetylcholine receptor M1 GPCR ALLOSTERIC MODULATOR Kd 4.80 IUPHAR
Muscarinic acetylcholine receptor M4 GPCR ALLOSTERIC MODULATOR Kd 4.20 IUPHAR

External reference:

IDSource
N0000166956 NUI
C0042674 UMLSCUI
D08677 KEGG_DRUG
11201 RXNORM
698876002 SNOMEDCT_US
005682 NDDF
996XVD0JHT UNII
2714 INN_ID
CHEMBL1165342 ChEMBL_ID
CHEBI:9985 CHEBI
D014749 MESH_DESCRIPTOR_UI
DB13374 DRUGBANK_ID
15376 PUBCHEM_CID
349 IUPHAR_LIGAND_ID

Pharmaceutical products:

None