betacarotene 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
arotinoid derivatives 345 7235-40-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • betacarotene
  • provatene
  • beta-Carotene
  • beta carotene
A carotenoid that is a precursor of VITAMIN A. Beta carotene is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC).
  • Molecular weight: 536.89
  • Formula: C40H56
  • CLOGP: 12
  • LIPINSKI: 2
  • HAC: 0
  • HDO: 0
  • TPSA:
  • ALOGS: -6.14
  • ROTB: 10
  • Status: OFM
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.10 g O

ADMET properties:

PropertyValueReference
BA (Bioavailability) 25 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Appendicolith 268.34 113.66 66 1670 8535 34946660
Appendicitis 232.79 113.66 66 1670 14741 34940454
Ventricular fibrillation 204.24 113.66 66 1670 22888 34932307
Cardiogenic shock 198.60 113.66 67 1669 26551 34928644
Stress 189.99 113.66 67 1669 30280 34924915
Blood phosphorus increased 170.40 113.66 45 1691 7676 34947519
Ascites 158.68 113.66 66 1670 46505 34908690
Hyponatraemia 148.45 113.66 75 1661 82616 34872579
Abdominal distension 144.21 113.66 66 1670 58426 34896769
Multiple organ dysfunction syndrome 130.20 113.66 67 1669 76499 34878696

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Appendicolith 312.28 54.98 66 1969 8485 79733868
Appendicitis 253.94 54.98 66 1969 20728 79721625
Ventricular fibrillation 225.91 54.98 66 1969 31860 79710493
Cardiogenic shock 212.36 54.98 67 1968 41847 79700506
Stress 188.13 54.98 72 1963 79540 79662813
Blood phosphorus increased 186.98 54.98 45 1990 10302 79732051
Ascites 170.13 54.98 66 1969 75496 79666857
Multiple organ dysfunction syndrome 146.80 54.98 68 1967 120178 79622175
Hyponatraemia 141.14 54.98 75 1960 177773 79564580
Abdominal distension 140.88 54.98 66 1969 119584 79622769
Dry mouth 92.58 54.98 45 1990 87974 79654379
General physical health deterioration 92.03 54.98 67 1968 275171 79467182
Sepsis 91.02 54.98 66 1969 269362 79472991
Myasthenia gravis 89.05 54.98 25 2010 10374 79731979
Constipation 88.10 54.98 66 1969 282984 79459369
Blood uric acid increased 87.19 54.98 26 2009 13334 79729019
Abdominal pain 73.53 54.98 68 1967 389501 79352852

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A11CA02 ALIMENTARY TRACT AND METABOLISM
VITAMINS
VITAMIN A AND D, INCL. COMBINATIONS OF THE TWO
Vitamin A, plain
ATC D02BB01 DERMATOLOGICALS
EMOLLIENTS AND PROTECTIVES
PROTECTIVES AGAINST UV-RADIATION
Protectives against UV-radiation for systemic use
CHEBI has role CHEBI:22586 antioxidants
CHEBI has role CHEBI:23357 cofactor
CHEBI has role CHEBI:26130 pigments
CHEBI has role CHEBI:67200 provitamin As
CHEBI has role CHEBI:75771 Mus musculus metabolites
CHEBI has role CHEBI:76924 plant metabolites
CHEBI has role CHEBI:77746 Homo sapiens metabolite
CHEBI has role CHEBI:173084 ferroptosis inhibitors
MeSH PA D018977 Micronutrients
MeSH PA D000072664 Provitamins
MeSH PA D014815 Vitamins

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Primary hyperoxaluria contraindication 17901006 DOID:2977
Blood coagulation disorder contraindication 64779008 DOID:1247
Wilson's disease contraindication 88518009
Anemia due to enzyme deficiency contraindication 111577008
Hb SS disease contraindication 127040003 DOID:10923
Hemochromatosis contraindication 399187006 DOID:2352
Vitamin K Deficiency Induced Hypoprothrombinemia contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Core protein Unclassified IC50 4.53 CHEMBL

External reference:

IDSource
4020599 VUID
N0000148286 NUI
D03101 KEGG_DRUG
19143 RXNORM
C0053396 UMLSCUI
CHEBI:17579 CHEBI
BCR PDB_CHEM_ID
CHEMBL1293 ChEMBL_ID
D019207 MESH_DESCRIPTOR_UI
DB06755 DRUGBANK_ID
4229 INN_ID
01YAE03M7J UNII
5280489 PUBCHEM_CID
4269 MMSL
5679 MMSL
6766 MMSL
d01385 MMSL
103068006 SNOMEDCT_US
329507006 SNOMEDCT_US
4017793 VANDF
4020599 VANDF
001003 NDDF
002022 NDDF

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Select OB HUMAN PRESCRIPTION DRUG LABEL 15 0642-0077 TABLET, CHEWABLE 600 [iU] ORAL UNAPPROVED DRUG OTHER 14 sections
Vitafol Ultra HUMAN PRESCRIPTION DRUG LABEL 17 0642-0093 CAPSULE, LIQUID FILLED 330 ug ORAL UNAPPROVED DRUG OTHER 13 sections
Vitafol Ultra HUMAN PRESCRIPTION DRUG LABEL 17 0642-0093 CAPSULE, LIQUID FILLED 330 ug ORAL UNAPPROVED DRUG OTHER 13 sections
Select OB HUMAN PRESCRIPTION DRUG LABEL 15 0642-0120 TABLET, CHEWABLE 600 [iU] ORAL UNAPPROVED DRUG OTHER 13 sections
Vitafol Fe Plus HUMAN PRESCRIPTION DRUG LABEL 17 0642-7473 CAPSULE, LIQUID FILLED 330 ug ORAL UNAPPROVED DRUG OTHER 14 sections
Vitafol Fe Plus HUMAN PRESCRIPTION DRUG LABEL 17 0642-7473 CAPSULE, LIQUID FILLED 330 ug ORAL UNAPPROVED DRUG OTHER 14 sections
PRENATAL PLUS HUMAN PRESCRIPTION DRUG LABEL 15 10544-549 TABLET, FILM COATED 920 [iU] ORAL unapproved drug other 8 sections
PRENATAL PLUS IRON HUMAN PRESCRIPTION DRUG LABEL 15 10544-609 TABLET, FILM COATED 920 [iU] ORAL UNAPPROVED DRUG OTHER 7 sections
Se-Natal 19 HUMAN PRESCRIPTION DRUG LABEL 15 13925-116 TABLET 1000 [iU] ORAL unapproved drug other 15 sections
Se-Natal 19 HUMAN PRESCRIPTION DRUG LABEL 15 13925-116 TABLET 1000 [iU] ORAL unapproved drug other 15 sections
Se-Natal 19 Chewable HUMAN PRESCRIPTION DRUG LABEL 14 13925-117 TABLET, CHEWABLE 1000 [iU] ORAL unapproved drug other 16 sections
PRENATAL PLUS HUMAN PRESCRIPTION DRUG LABEL 15 15338-522 TABLET, FILM COATED 920 [iU] ORAL unapproved drug other 8 sections
PRENATAL PLUS HUMAN PRESCRIPTION DRUG LABEL 15 17856-0668 TABLET, FILM COATED 920 [iU] ORAL UNAPPROVED DRUG OTHER 6 sections
Prenatal Plus Vitamins HUMAN PRESCRIPTION DRUG LABEL 15 39328-106 TABLET 276 ug ORAL UNAPPROVED DRUG OTHER 7 sections
PRENATAL PLUS HUMAN PRESCRIPTION DRUG LABEL 15 42291-686 TABLET, FILM COATED 920 [iU] ORAL unapproved drug other 8 sections
NataChew HUMAN PRESCRIPTION DRUG LABEL 11 44118-902 TABLET, CHEWABLE 2700 [iU] ORAL unapproved drug other 7 sections
Prenatal Vitamins Plus Low Iron HUMAN PRESCRIPTION DRUG LABEL 15 50090-0616 TABLET 920 [iU] ORAL Unapproved drug other 9 sections
PNV Prenatal Plus Multivitamin HUMAN PRESCRIPTION DRUG LABEL 15 50090-0617 TABLET 2000 [iU] ORAL Unapproved drug other 9 sections
PRENATAL PLUS HUMAN PRESCRIPTION DRUG LABEL 15 50268-677 TABLET, FILM COATED 920 [iU] ORAL unapproved drug other 8 sections
Floriva HUMAN PRESCRIPTION DRUG LABEL 16 52796-173 TABLET, CHEWABLE 1000 [iU] ORAL UNAPPROVED DRUG OTHER 6 sections
Floriva HUMAN PRESCRIPTION DRUG LABEL 16 52796-174 TABLET, CHEWABLE 1000 [iU] ORAL UNAPPROVED DRUG OTHER 6 sections
Floriva HUMAN PRESCRIPTION DRUG LABEL 16 52796-177 TABLET, CHEWABLE 1000 [iU] ORAL UNAPPROVED DRUG OTHER 7 sections
healthy mamaBE WELL ROUNDED BE WELL ROUNDED HUMAN PRESCRIPTION DRUG LABEL 17 58154-107 TABLET, FILM COATED 4000 [iU] ORAL unapproved drug other 8 sections
Active FE HUMAN PRESCRIPTION DRUG LABEL 14 58809-725 TABLET 2100 [iU] ORAL UNAPPROVED DRUG OTHER 17 sections
PNV Prenatal Plus Multivitamin HUMAN PRESCRIPTION DRUG LABEL 15 63629-6973 TABLET 2000 [iU] ORAL Unapproved drug other 9 sections
PRENATAL PLUS HUMAN PRESCRIPTION DRUG LABEL 15 65162-668 TABLET, FILM COATED 920 [iU] ORAL unapproved drug other 8 sections
PRENATAL PLUS HUMAN PRESCRIPTION DRUG LABEL 15 65162-668 TABLET, FILM COATED 920 [iU] ORAL unapproved drug other 8 sections
PRENATAL PLUS HUMAN PRESCRIPTION DRUG LABEL 15 68151-2640 TABLET, FILM COATED 920 [iU] ORAL UNAPPROVED DRUG OTHER 8 sections
Prenatal Vitamins Plus Low Iron HUMAN PRESCRIPTION DRUG LABEL 15 68151-5878 TABLET 920 [iU] ORAL Unapproved drug other 9 sections
Prenatal Vitamins Plus Low Iron HUMAN PRESCRIPTION DRUG LABEL 15 70518-2746 TABLET 920 [iU] ORAL unapproved drug other 9 sections