betacarotene 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
arotinoid derivatives	345	7235-40-7

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: betacarotene provatene beta-Carotene beta carotene	A carotenoid that is a precursor of VITAMIN A. Beta carotene is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). Molecular weight: 536.89 Formula: C40H56 CLOGP: 12 LIPINSKI: 2 HAC: 0 HDO: 0 TPSA: ALOGS: -6.14 ROTB: 10 Status: OFM Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

betacarotene
provatene
beta-Carotene
beta carotene

A carotenoid that is a precursor of VITAMIN A. Beta carotene is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC).

Molecular weight: 536.89
Formula: C40H56
CLOGP: 12
LIPINSKI: 2
HAC: 0
HDO: 0
TPSA:
ALOGS: -6.14
ROTB: 10

Status: OFM

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
0.10	g	O

ADMET properties:

Property	Value	Reference
BA (Bioavailability)	25 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

Date	Agency	Company	Orphan
None	FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Appendicolith	209.27	71.41	40	964	5640	70921800
Appendicitis	166.20	71.41	40	964	16693	70910747
Ventricular fibrillation	142.37	71.41	39	965	27072	70900368
Cardiogenic shock	135.48	71.41	40	964	36267	70891173
Stress	126.11	71.41	44	960	67922	70859518
Ascites	111.08	71.41	40	964	67507	70859933
Hyponatraemia	104.99	71.41	49	955	160038	70767402
Multiple organ dysfunction syndrome	95.98	71.41	41	963	108474	70818966
Abdominal distension	94.06	71.41	40	964	104629	70822811

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	A11CA02	ALIMENTARY TRACT AND METABOLISM VITAMINS VITAMIN A AND D, INCL. COMBINATIONS OF THE TWO Vitamin A, plain
ATC	D02BB01	DERMATOLOGICALS EMOLLIENTS AND PROTECTIVES PROTECTIVES AGAINST UV-RADIATION Protectives against UV-radiation for systemic use
CHEBI has role	CHEBI:22586	antioxidants
CHEBI has role	CHEBI:23357	cofactor
CHEBI has role	CHEBI:26130	pigments
CHEBI has role	CHEBI:67200	provitamin As
CHEBI has role	CHEBI:75771	Mus musculus metabolites
CHEBI has role	CHEBI:76924	plant metabolites
CHEBI has role	CHEBI:77746	Homo sapiens metabolite
CHEBI has role	CHEBI:173084	ferroptosis inhibitors
MeSH PA	D018977	Micronutrients
MeSH PA	D000072664	Provitamins
MeSH PA	D014815	Vitamins

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Primary hyperoxaluria	contraindication	17901006	DOID:2977
Blood coagulation disorder	contraindication	64779008	DOID:1247
Wilson's disease	contraindication	88518009
Anemia due to enzyme deficiency	contraindication	111577008
Hb SS disease	contraindication	127040003	DOID:10923
Hemochromatosis	contraindication	399187006	DOID:2352
Vitamin K Deficiency Induced Hypoprothrombinemia	contraindication

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Core protein	Unclassified		Q2Q167_9HEPC		IC50	4.53		CHEMBL

External reference:

ID	Source
4020599	VUID
N0000148286	NUI
D03101	KEGG_DRUG
19143	RXNORM
4017793	VANDF
4020599	VANDF
C0053396	UMLSCUI
CHEBI:17579	CHEBI
BCR	PDB_CHEM_ID
CHEMBL1293	ChEMBL_ID
D019207	MESH_DESCRIPTOR_UI
DB06755	DRUGBANK_ID
4229	INN_ID
01YAE03M7J	UNII
5280489	PUBCHEM_CID
4269	MMSL
5679	MMSL
6766	MMSL
d01385	MMSL
001003	NDDF
002022	NDDF
103068006	SNOMEDCT_US
329507006	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Select OB	HUMAN PRESCRIPTION DRUG LABEL	15	0642-0077	TABLET, CHEWABLE	600 [iU]	ORAL	UNAPPROVED DRUG OTHER	14 sections
Vitafol Ultra	HUMAN PRESCRIPTION DRUG LABEL	17	0642-0093	CAPSULE, LIQUID FILLED	330 ug	ORAL	UNAPPROVED DRUG OTHER	13 sections
Select OB	HUMAN PRESCRIPTION DRUG LABEL	15	0642-0120	TABLET, CHEWABLE	600 [iU]	ORAL	UNAPPROVED DRUG OTHER	13 sections
Vitafol Fe Plus	HUMAN PRESCRIPTION DRUG LABEL	17	0642-7473	CAPSULE, LIQUID FILLED	330 ug	ORAL	UNAPPROVED DRUG OTHER	14 sections
PRENATAL PLUS	HUMAN PRESCRIPTION DRUG LABEL	15	10544-549	TABLET, FILM COATED	920 [iU]	ORAL	unapproved drug other	8 sections
PRENATAL PLUS IRON	HUMAN PRESCRIPTION DRUG LABEL	15	10544-609	TABLET, FILM COATED	920 [iU]	ORAL	UNAPPROVED DRUG OTHER	7 sections
Se-Natal 19	HUMAN PRESCRIPTION DRUG LABEL	15	13925-116	TABLET	1000 [iU]	ORAL	unapproved drug other	15 sections
Se-Natal 19	HUMAN PRESCRIPTION DRUG LABEL	15	13925-116	TABLET	1000 [iU]	ORAL	unapproved drug other	15 sections
Se-Natal 19 Chewable	HUMAN PRESCRIPTION DRUG LABEL	14	13925-117	TABLET, CHEWABLE	1000 [iU]	ORAL	unapproved drug other	16 sections
PRENATAL PLUS	HUMAN PRESCRIPTION DRUG LABEL	15	15338-522	TABLET, FILM COATED	920 [iU]	ORAL	unapproved drug other	8 sections
PRENATAL PLUS	HUMAN PRESCRIPTION DRUG LABEL	15	17856-0668	TABLET, FILM COATED	920 [iU]	ORAL	UNAPPROVED DRUG OTHER	6 sections
Prenatal Plus Vitamins	HUMAN PRESCRIPTION DRUG LABEL	15	39328-106	TABLET	276 ug	ORAL	UNAPPROVED DRUG OTHER	7 sections
PRENATAL PLUS	HUMAN PRESCRIPTION DRUG LABEL	15	42291-686	TABLET, FILM COATED	920 [iU]	ORAL	unapproved drug other	8 sections
NataChew	HUMAN PRESCRIPTION DRUG LABEL	11	44118-902	TABLET, CHEWABLE	2700 [iU]	ORAL	unapproved drug other	7 sections
Prenatal Vitamins Plus Low Iron	HUMAN PRESCRIPTION DRUG LABEL	15	50090-0616	TABLET	920 [iU]	ORAL	Unapproved drug other	9 sections
PNV Prenatal Plus Multivitamin	HUMAN PRESCRIPTION DRUG LABEL	15	50090-0617	TABLET	2000 [iU]	ORAL	Unapproved drug other	9 sections
PRENATAL PLUS	HUMAN PRESCRIPTION DRUG LABEL	15	50268-677	TABLET, FILM COATED	920 [iU]	ORAL	unapproved drug other	8 sections
Floriva	HUMAN PRESCRIPTION DRUG LABEL	16	52796-173	TABLET, CHEWABLE	1000 [iU]	ORAL	UNAPPROVED DRUG OTHER	6 sections
Floriva	HUMAN PRESCRIPTION DRUG LABEL	16	52796-174	TABLET, CHEWABLE	1000 [iU]	ORAL	UNAPPROVED DRUG OTHER	6 sections
Floriva	HUMAN PRESCRIPTION DRUG LABEL	16	52796-177	TABLET, CHEWABLE	1000 [iU]	ORAL	UNAPPROVED DRUG OTHER	7 sections
healthy mamaBE WELL ROUNDED BE WELL ROUNDED	HUMAN PRESCRIPTION DRUG LABEL	17	58154-107	TABLET, FILM COATED	4000 [iU]	ORAL	unapproved drug other	8 sections
Active FE	HUMAN PRESCRIPTION DRUG LABEL	14	58809-725	TABLET	2100 [iU]	ORAL	UNAPPROVED DRUG OTHER	17 sections
PNV Prenatal Plus Multivitamin	HUMAN PRESCRIPTION DRUG LABEL	15	63629-6973	TABLET	2000 [iU]	ORAL	Unapproved drug other	9 sections
PRENATAL PLUS	HUMAN PRESCRIPTION DRUG LABEL	15	65162-668	TABLET, FILM COATED	920 [iU]	ORAL	unapproved drug other	8 sections
PRENATAL PLUS	HUMAN PRESCRIPTION DRUG LABEL	15	65162-668	TABLET, FILM COATED	920 [iU]	ORAL	unapproved drug other	8 sections
PRENATAL PLUS	HUMAN PRESCRIPTION DRUG LABEL	15	68151-2640	TABLET, FILM COATED	920 [iU]	ORAL	UNAPPROVED DRUG OTHER	8 sections
Prenatal Vitamins Plus Low Iron	HUMAN PRESCRIPTION DRUG LABEL	15	68151-5878	TABLET	920 [iU]	ORAL	Unapproved drug other	9 sections
Prenatal Vitamins Plus Low Iron	HUMAN PRESCRIPTION DRUG LABEL	15	70518-2746	TABLET	920 [iU]	ORAL	unapproved drug other	9 sections
PNV Prenatal Plus Multivitamin	HUMAN PRESCRIPTION DRUG LABEL	15	71335-0440	TABLET	2000 [iU]	ORAL	Unapproved drug other	9 sections
NEONATAL DHA	HUMAN PRESCRIPTION DRUG LABEL	18	73317-6288	TABLET	1200 ug	ORAL	unapproved drug other	10 sections