betacarotene 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
arotinoid derivatives 345 7235-40-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • betacarotene
  • provatene
  • beta-Carotene
  • beta carotene
A carotenoid that is a precursor of VITAMIN A. Beta carotene is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC).
  • Molecular weight: 536.89
  • Formula: C40H56
  • CLOGP: 12
  • LIPINSKI: 2
  • HAC: 0
  • HDO: 0
  • TPSA:
  • ALOGS: -6.14
  • ROTB: 10

  • Status: OFM

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.10 g O

ADMET properties:

PropertyValueReference
BA (Bioavailability) 25 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

DateAgencyCompanyOrphan
None FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Appendicolith 85.49 59.86 16 516 3453 64494747
Appendicitis 63.75 59.86 16 516 13553 64484647

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A11CA02 ALIMENTARY TRACT AND METABOLISM
VITAMINS
VITAMIN A AND D, INCL. COMBINATIONS OF THE TWO
Vitamin A, plain
ATC D02BB01 DERMATOLOGICALS
EMOLLIENTS AND PROTECTIVES
PROTECTIVES AGAINST UV-RADIATION
Protectives against UV-radiation for systemic use
CHEBI has role CHEBI:22586 antioxidants
CHEBI has role CHEBI:23357 cofactor
CHEBI has role CHEBI:26130 pigments
CHEBI has role CHEBI:67200 provitamin As
CHEBI has role CHEBI:75771 Mus musculus metabolites
CHEBI has role CHEBI:76924 plant metabolites
CHEBI has role CHEBI:77746 Homo sapiens metabolite
CHEBI has role CHEBI:173084 ferroptosis inhibitors
MeSH PA D018977 Micronutrients
MeSH PA D000072664 Provitamins
MeSH PA D014815 Vitamins

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Primary hyperoxaluria contraindication 17901006 DOID:2977
Blood coagulation disorder contraindication 64779008 DOID:1247
Wilson's disease contraindication 88518009
Anemia due to enzyme deficiency contraindication 111577008
Hb SS disease contraindication 127040003 DOID:10923
Hemochromatosis contraindication 399187006 DOID:2352
Vitamin K Deficiency Induced Hypoprothrombinemia contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Core protein Unclassified IC50 4.53 CHEMBL

External reference:

IDSource
4020599 VUID
N0000148286 NUI
D03101 KEGG_DRUG
19143 RXNORM
C0053396 UMLSCUI
CHEBI:17579 CHEBI
BCR PDB_CHEM_ID
CHEMBL1293 ChEMBL_ID
D019207 MESH_DESCRIPTOR_UI
DB06755 DRUGBANK_ID
4229 INN_ID
01YAE03M7J UNII
5280489 PUBCHEM_CID
4269 MMSL
5679 MMSL
6766 MMSL
d01385 MMSL
001003 NDDF
002022 NDDF
4017793 VANDF
4020599 VANDF
103068006 SNOMEDCT_US
329507006 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Select OB HUMAN PRESCRIPTION DRUG LABEL 15 0642-0077 TABLET, CHEWABLE 600 [iU] ORAL UNAPPROVED DRUG OTHER 14 sections
Vitafol Ultra HUMAN PRESCRIPTION DRUG LABEL 17 0642-0093 CAPSULE, LIQUID FILLED 330 ug ORAL UNAPPROVED DRUG OTHER 13 sections
Select OB HUMAN PRESCRIPTION DRUG LABEL 15 0642-0120 TABLET, CHEWABLE 600 [iU] ORAL UNAPPROVED DRUG OTHER 13 sections
Vitafol Fe Plus HUMAN PRESCRIPTION DRUG LABEL 17 0642-7473 CAPSULE, LIQUID FILLED 330 ug ORAL UNAPPROVED DRUG OTHER 14 sections
PRENATAL PLUS HUMAN PRESCRIPTION DRUG LABEL 15 10544-549 TABLET, FILM COATED 920 [iU] ORAL unapproved drug other 8 sections
PRENATAL PLUS IRON HUMAN PRESCRIPTION DRUG LABEL 15 10544-609 TABLET, FILM COATED 920 [iU] ORAL UNAPPROVED DRUG OTHER 7 sections
Se-Natal 19 HUMAN PRESCRIPTION DRUG LABEL 15 13925-116 TABLET 1000 [iU] ORAL unapproved drug other 15 sections
Se-Natal 19 HUMAN PRESCRIPTION DRUG LABEL 15 13925-116 TABLET 1000 [iU] ORAL unapproved drug other 15 sections
Se-Natal 19 Chewable HUMAN PRESCRIPTION DRUG LABEL 14 13925-117 TABLET, CHEWABLE 1000 [iU] ORAL unapproved drug other 16 sections
PRENATAL PLUS HUMAN PRESCRIPTION DRUG LABEL 15 15338-522 TABLET, FILM COATED 920 [iU] ORAL unapproved drug other 8 sections
PRENATAL PLUS HUMAN PRESCRIPTION DRUG LABEL 15 17856-0668 TABLET, FILM COATED 920 [iU] ORAL UNAPPROVED DRUG OTHER 6 sections
Prenatal Plus Vitamins HUMAN PRESCRIPTION DRUG LABEL 15 39328-106 TABLET 276 ug ORAL UNAPPROVED DRUG OTHER 7 sections
PRENATAL PLUS HUMAN PRESCRIPTION DRUG LABEL 15 42291-686 TABLET, FILM COATED 920 [iU] ORAL unapproved drug other 8 sections
NataChew HUMAN PRESCRIPTION DRUG LABEL 11 44118-902 TABLET, CHEWABLE 2700 [iU] ORAL unapproved drug other 7 sections
Prenatal Vitamins Plus Low Iron HUMAN PRESCRIPTION DRUG LABEL 15 50090-0616 TABLET 920 [iU] ORAL Unapproved drug other 9 sections
PNV Prenatal Plus Multivitamin HUMAN PRESCRIPTION DRUG LABEL 15 50090-0617 TABLET 2000 [iU] ORAL Unapproved drug other 9 sections
PRENATAL PLUS HUMAN PRESCRIPTION DRUG LABEL 15 50268-677 TABLET, FILM COATED 920 [iU] ORAL unapproved drug other 8 sections
Floriva HUMAN PRESCRIPTION DRUG LABEL 16 52796-173 TABLET, CHEWABLE 1000 [iU] ORAL UNAPPROVED DRUG OTHER 6 sections
Floriva HUMAN PRESCRIPTION DRUG LABEL 16 52796-174 TABLET, CHEWABLE 1000 [iU] ORAL UNAPPROVED DRUG OTHER 6 sections
Floriva HUMAN PRESCRIPTION DRUG LABEL 16 52796-177 TABLET, CHEWABLE 1000 [iU] ORAL UNAPPROVED DRUG OTHER 7 sections
healthy mamaBE WELL ROUNDED BE WELL ROUNDED HUMAN PRESCRIPTION DRUG LABEL 17 58154-107 TABLET, FILM COATED 4000 [iU] ORAL unapproved drug other 8 sections
Active FE HUMAN PRESCRIPTION DRUG LABEL 14 58809-725 TABLET 2100 [iU] ORAL UNAPPROVED DRUG OTHER 17 sections
PNV Prenatal Plus Multivitamin HUMAN PRESCRIPTION DRUG LABEL 15 63629-6973 TABLET 2000 [iU] ORAL Unapproved drug other 9 sections
PRENATAL PLUS HUMAN PRESCRIPTION DRUG LABEL 15 65162-668 TABLET, FILM COATED 920 [iU] ORAL unapproved drug other 8 sections
PRENATAL PLUS HUMAN PRESCRIPTION DRUG LABEL 15 65162-668 TABLET, FILM COATED 920 [iU] ORAL unapproved drug other 8 sections
PRENATAL PLUS HUMAN PRESCRIPTION DRUG LABEL 15 68151-2640 TABLET, FILM COATED 920 [iU] ORAL UNAPPROVED DRUG OTHER 8 sections
Prenatal Vitamins Plus Low Iron HUMAN PRESCRIPTION DRUG LABEL 15 68151-5878 TABLET 920 [iU] ORAL Unapproved drug other 9 sections
Prenatal Vitamins Plus Low Iron HUMAN PRESCRIPTION DRUG LABEL 15 70518-2746 TABLET 920 [iU] ORAL unapproved drug other 9 sections
PNV Prenatal Plus Multivitamin HUMAN PRESCRIPTION DRUG LABEL 15 71335-0440 TABLET 2000 [iU] ORAL Unapproved drug other 9 sections
NEONATAL DHA HUMAN PRESCRIPTION DRUG LABEL 18 73317-6288 TABLET 1200 ug ORAL unapproved drug other 10 sections