betacarotene Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
arotinoid derivatives	345	7235-40-7

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: betacarotene provatene beta-Carotene beta carotene	A carotenoid that is a precursor of VITAMIN A. Beta carotene is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC). Molecular weight: 536.89 Formula: C40H56 CLOGP: 15.23 LIPINSKI: 2 HAC: 0 HDO: 0 TPSA: ALOGS: -6.14 ROTB: 10

Molecule

Description

Molfile Inchi Smiles

Synonyms:

betacarotene
provatene
beta-Carotene
beta carotene

A carotenoid that is a precursor of VITAMIN A. Beta carotene is administered to reduce the severity of photosensitivity reactions in patients with erythropoietic protoporphyria (PORPHYRIA, ERYTHROPOIETIC).

Molecular weight: 536.89
Formula: C40H56
CLOGP: 15.23
LIPINSKI: 2
HAC: 0
HDO: 0
TPSA:
ALOGS: -6.14
ROTB: 10

Drug dosage:

Dose	Unit	Route
0.10	g	O

ADMET properties:

Property	Value	Reference
BA (Bioavailability)	25 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

Date	Agency	Company	Orphan
None	FDA

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

Source	Code	Description
ATC	A11CA02	ALIMENTARY TRACT AND METABOLISM VITAMINS VITAMIN A AND D, INCL. COMBINATIONS OF THE TWO Vitamin A, plain
ATC	D02BB01	DERMATOLOGICALS EMOLLIENTS AND PROTECTIVES PROTECTIVES AGAINST UV-RADIATION Protectives against UV-radiation for systemic use
MeSH PA	D018977	Micronutrients
MeSH PA	D000072664	Provitamins
MeSH PA	D014815	Vitamins

Drug Use (View source of the data)

Disease	Relation	SNOMED_ID	DOID
Primary hyperoxaluria	contraindication	17901006	DOID:2977
Blood coagulation disorder	contraindication	64779008	DOID:1247
Wilson's disease	contraindication	88518009
Anemia due to enzyme deficiency	contraindication	111577008
Hb SS disease	contraindication	127040003	DOID:10923
Hemochromatosis	contraindication	399187006	DOID:2352
Vitamin K Deficiency Induced Hypoprothrombinemia	contraindication

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Core protein	Unclassified		Q2Q167_9HEPC		IC50	4.53		CHEMBL

External reference:

ID	Source
4020599	VUID
N0000148286	NUI
C0053396	UMLSCUI
D03101	KEGG_DRUG
01YAE03M7J	UNII
4229	INN_ID
103068006	SNOMEDCT_US
329507006	SNOMEDCT_US
6766	MMSL
19143	RXNORM
4269	MMSL
d01385	MMSL
5679	MMSL
4020599	VANDF
4017793	VANDF
001003	NDDF
002022	NDDF
CHEMBL1293	ChEMBL_ID
BCR	PDB_CHEM_ID
DB06755	DRUGBANK_ID
CHEBI:17579	CHEBI
D019207	MESH_DESCRIPTOR_UI
5280489	PUBCHEM_CID

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Select-OB Plus DHA	HUMAN PRESCRIPTION DRUG LABEL	15	0642-0075	KIT	600 [iU]	None	Unapproved drug other	10 sections
Vitafol	HUMAN PRESCRIPTION DRUG LABEL	16	0642-0093	CAPSULE, LIQUID FILLED	1100 [iU]	ORAL	UNAPPROVED DRUG OTHER	10 sections
Vitafol Fe Plus	HUMAN PRESCRIPTION DRUG LABEL	16	0642-7473	CAPSULE, LIQUID FILLED	1100 [iU]	ORAL	UNAPPROVED DRUG OTHER	10 sections
PRENATAL PLUS	HUMAN PRESCRIPTION DRUG LABEL	15	10544-549	TABLET, FILM COATED	920 [iU]	ORAL	unapproved drug other	8 sections
Prenatal Vitamins Plus Low Iron	HUMAN PRESCRIPTION DRUG LABEL	13	39328-106	TABLET	920 [iU]	ORAL	Unapproved drug other	8 sections
Bal-Care DHA	HUMAN PRESCRIPTION DRUG LABEL	16	42546-180	KIT	2850 [iU]	None	unapproved drug other	4 sections
Bal-Care DHA Essential	HUMAN PRESCRIPTION DRUG LABEL	16	42546-185	KIT	2850 [iU]	None	unapproved drug other	4 sections
Moms Choice Rx	HUMAN PRESCRIPTION DRUG LABEL	14	42546-190	KIT	2840 [iU]	None	unapproved drug other	5 sections
PR Natal 400 ec	HUMAN PRESCRIPTION DRUG LABEL	14	42546-517	KIT	3000 [iU]	None	unapproved drug other	11 sections
PR Natal 430 ec	HUMAN PRESCRIPTION DRUG LABEL	14	42546-518	KIT	3000 [iU]	None	unapproved drug other	11 sections
PR Natal 400	HUMAN PRESCRIPTION DRUG LABEL	14	42546-811	KIT	3000 [iU]	None	unapproved drug other	11 sections
PR Natal 430	HUMAN PRESCRIPTION DRUG LABEL	14	42546-812	KIT	3000 [iU]	None	unapproved drug other	11 sections
PreNatal 19	HUMAN PRESCRIPTION DRUG LABEL	14	42937-706	TABLET, COATED	1000 [iU]	ORAL	UNAPPROVED DRUG OTHER	10 sections
PreNatal 19	HUMAN PRESCRIPTION DRUG LABEL	13	42937-707	TABLET, CHEWABLE	1000 [iU]	ORAL	UNAPPROVED DRUG OTHER	10 sections
Floriva	HUMAN PRESCRIPTION DRUG LABEL	15	52796-173	TABLET, CHEWABLE	1000 [iU]	ORAL	UNAPPROVED DRUG OTHER	6 sections
Floriva	HUMAN PRESCRIPTION DRUG LABEL	15	52796-174	TABLET, CHEWABLE	1000 [iU]	ORAL	UNAPPROVED DRUG OTHER	6 sections
Floriva	HUMAN PRESCRIPTION DRUG LABEL	15	52796-177	TABLET, CHEWABLE	1000 [iU]	ORAL	UNAPPROVED DRUG OTHER	7 sections