lenalidomide 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antineoplastics, thalidomide derivatives 3317 191732-72-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • lenalidomide hydrate
  • lenalidomide
  • revimid
  • revlimid
Lenalidomide is an analogue of thalidomide with immunomodulatory, antiangiogenic, and antineoplastic properties. Lenalidomide inhibits proliferation and induces apoptosis of certain hematopoietic tumor cells including multiple myeloma, mantle cell lymphoma, and del (5q) myelodysplastic syndromes in vitro. Lenalidomide causes a delay in tumor growth in some in vivo nonclinical hematopoietic tumor models including multiple myeloma. Immunomodulatory properties of lenalidomide include activation of T cells and natural killer (NK) cells, increased numbers of NKT cells, and inhibition of pro-inflammatory cytokines (e.g., TNF-alpha and IL-6) by monocytes. In multiple myeloma cells, the combination of lenalidomide and dexamethasone synergizes the inhibition of cell proliferation and the induction of apoptosis.
  • Molecular weight: 259.27
  • Formula: C13H13N3O3
  • CLOGP: -0.41
  • LIPINSKI: 0
  • HAC: 6
  • HDO: 2
  • TPSA: 92.50
  • ALOGS: -2.05
  • ROTB: 1
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
10 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Bocci G, Oprea TI, Benet LZ
S (Water solubility) 2.33 mg/mL Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine) 66 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 1.38 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD

Approvals:

DateAgencyCompanyOrphan
June 14, 2007 EMA CELEGENE EUROPE BV
Dec. 27, 2005 FDA CELGENE
June 25, 2010 PMDA Celgene K.K.

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Diarrhoea 7108.88 14.77 12327 288649 703039 62485007
Full blood count decreased 6487.50 14.77 2930 298046 23094 63164952
Death 5747.68 14.77 7909 293067 366472 62821574
White blood cell count decreased 4580.51 14.77 4372 296604 134732 63053314
Neuropathy peripheral 4214.63 14.77 3818 297158 109849 63078197
Thrombosis 3519.73 14.77 2715 298261 62040 63126006
Platelet count decreased 2976.86 14.77 3190 297786 112932 63075114
Laboratory test abnormal 2792.65 14.77 1684 299292 25228 63162818
Pneumonia 2624.45 14.77 6302 294674 450465 62737581
Constipation 1785.35 14.77 3541 297435 221402 62966644
Fatigue 1744.46 14.77 8543 292433 879485 62308561
Plasma cell myeloma 1703.82 14.77 1391 299585 34514 63153532
Muscle spasms 1583.65 14.77 2733 298243 153417 63034629
Unevaluable event 1575.83 14.77 1556 299420 49830 63138216
Rash 1479.96 14.77 5901 295075 554970 62633076
Drug ineffective 1441.99 14.77 1710 299266 1043055 62144991
Human chorionic gonadotropin increased 1318.04 14.77 430 300546 1155 63186891
Neutropenia 1292.01 14.77 2675 298301 172330 63015716
Condition aggravated 1155.45 14.77 249 300727 401968 62786078
Product dose omission issue 1079.44 14.77 2982 297994 231331 62956715
Adverse drug reaction 1077.86 14.77 1592 299384 78122 63109924
Rheumatoid arthritis 1012.61 14.77 45 300931 253774 62934272
Plasma cell myeloma recurrent 1011.88 14.77 427 300549 2786 63185260
Contraindicated product administered 977.16 14.77 10 300966 217638 62970408
Blood potassium decreased 974.92 14.77 1097 299879 40929 63147117
Maternal exposure during pregnancy 926.67 14.77 25 300951 220037 62968009
Systemic lupus erythematosus 905.87 14.77 17 300959 208901 62979145
Deep vein thrombosis 898.89 14.77 1505 299471 82295 63105751
Haemoglobin decreased 837.97 14.77 2015 298961 143470 63044576
Synovitis 819.49 14.77 13 300963 186905 63001141
Neutrophil count decreased 806.54 14.77 1157 299819 55249 63132797
COVID-19 771.34 14.77 1675 299301 111428 63076618
Pancytopenia 751.36 14.77 1513 299463 95420 63092626
Ageusia 728.08 14.77 568 300408 13160 63174886
Drug interaction 710.07 14.77 117 300859 229014 62959032
Tooth disorder 675.25 14.77 748 300228 27409 63160637
Product use issue 654.21 14.77 126 300850 220394 62967652
Completed suicide 647.69 14.77 8 300968 145665 63042381
Thrombocytopenia 642.52 14.77 1870 299106 149287 63038759
Red blood cell count decreased 637.95 14.77 872 300104 39773 63148273
Skin discolouration 626.38 14.77 833 300143 36995 63151051
Infusion related reaction 600.99 14.77 207 300769 245314 62942732
Glossodynia 596.95 14.77 73 300903 178803 63009243
Asthenia 583.49 14.77 3452 297524 380152 62807894
Exposure during pregnancy 581.63 14.77 40 300936 155507 63032539
Drug hypersensitivity 573.26 14.77 385 300591 310302 62877744
Treatment failure 569.06 14.77 124 300852 198919 62989127
Injection site pain 530.85 14.77 19 300957 129781 63058265
Renal disorder 528.92 14.77 715 300261 32259 63155787
Therapeutic product effect decreased 490.02 14.77 153 300823 193034 62995012
Pulmonary thrombosis 487.53 14.77 372 300604 8330 63179716
Cytopenia 485.01 14.77 418 300558 11183 63176863
Arthralgia 482.05 14.77 1262 299714 568448 62619598
Product use in unapproved indication 479.64 14.77 128 300848 178952 63009094
Rash pruritic 478.23 14.77 946 300030 58853 63129193
Discomfort 474.87 14.77 106 300870 167268 63020778
Pericarditis 474.46 14.77 40 300936 131539 63056507
Urinary tract infection 454.66 14.77 2462 298514 262222 62925824
Plasmacytoma 454.31 14.77 229 300747 2350 63185696
Dehydration 453.73 14.77 1824 299152 171530 63016516
Peripheral swelling 447.58 14.77 2460 298516 263482 62924564
Cardiac disorder 421.00 14.77 816 300160 50000 63138046
Pain 419.55 14.77 1948 299028 738680 62449366
Wound 416.32 14.77 128 300848 163135 63024911
Dry skin 384.60 14.77 840 300136 56047 63131999
Hip fracture 379.91 14.77 576 300400 28898 63159148
Headache 379.07 14.77 1631 299345 631610 62556436
Taste disorder 376.93 14.77 391 300585 13271 63174775
Anaemia 375.37 14.77 2528 298448 290902 62897144
Helicobacter infection 361.45 14.77 19 300957 92766 63095280
Rheumatoid factor positive 361.09 14.77 8 300968 84398 63103648
Renal failure 354.52 14.77 1295 299681 116357 63071689
Cataract 343.95 14.77 805 300171 56248 63131798
Mobility decreased 343.05 14.77 77 300899 121082 63066964
Full blood count abnormal 336.25 14.77 567 300409 31150 63156896
Seasonal allergy 332.47 14.77 452 300524 20498 63167548
Therapeutic product effect incomplete 331.72 14.77 91 300885 124965 63063081
Overdose 330.14 14.77 71 300905 115007 63073039
Monoclonal immunoglobulin present 322.04 14.77 129 300847 722 63187324
Multiple allergies 316.01 14.77 358 300618 13444 63174602
Folliculitis 307.53 14.77 5 300971 70312 63117734
Hepatic enzyme increased 306.57 14.77 304 300672 202024 62986022
Light chain analysis increased 296.98 14.77 139 300837 1194 63186852
Muscle injury 288.53 14.77 4 300972 65341 63122705
Full blood count increased 287.77 14.77 127 300849 937 63187109
Pulmonary embolism 284.74 14.77 1202 299774 115482 63072564
Off label use 281.23 14.77 1959 299017 672503 62515543
Injection site erythema 279.65 14.77 33 300943 83141 63104905
Spinal fracture 279.08 14.77 387 300589 17884 63170162
Fibromyalgia 275.18 14.77 30 300946 80390 63107656
Fall 269.43 14.77 2943 298033 389391 62798655
Blood test abnormal 269.20 14.77 351 300625 15278 63172768
Protein total increased 267.92 14.77 166 300810 2611 63185435
Psoriasis 259.09 14.77 49 300927 86908 63101138
Pruritus 256.29 14.77 2729 298247 358724 62829322
Impaired healing 247.97 14.77 88 300888 102454 63085592
Acute myeloid leukaemia 245.32 14.77 352 300624 16795 63171251
Lower respiratory tract infection 240.90 14.77 166 300810 132141 63055905
Suicide attempt 235.61 14.77 13 300963 60905 63127141
Swelling 232.91 14.77 609 300367 274769 62913277
Musculoskeletal stiffness 232.75 14.77 321 300655 184297 63003749
Sepsis 232.52 14.77 1379 299597 151744 63036302
Knee arthroplasty 232.38 14.77 5 300971 54201 63133845
Alopecia 228.94 14.77 826 300150 336710 62851336
Plasma cell leukaemia 224.79 14.77 109 300867 1021 63187025
Hordeolum 221.09 14.77 157 300819 3135 63184911
Type 2 diabetes mellitus 220.62 14.77 23 300953 63845 63124201
Inappropriate schedule of product administration 219.64 14.77 109 300867 103856 63084190
Body height decreased 218.23 14.77 254 300722 9824 63178222
Tachycardia 212.78 14.77 150 300826 118006 63070040
Hypertension 212.35 14.77 650 300326 278653 62909393
Migraine 211.40 14.77 113 300863 103233 63084813
Wrong technique in product usage process 211.39 14.77 24 300952 62316 63125730
Intentional product misuse 207.71 14.77 23 300953 60894 63127152
Oxygen saturation decreased 207.49 14.77 80 300896 88505 63099541
Influenza 206.67 14.77 1041 299935 107681 63080365
Myelodysplastic syndrome 205.45 14.77 320 300656 16434 63171612
Aspartate aminotransferase increased 204.16 14.77 86 300890 90191 63097855
Gastric disorder 203.45 14.77 507 300469 36862 63151184
Alanine aminotransferase increased 201.45 14.77 121 300855 103649 63084397
Wheezing 200.77 14.77 101 300875 95494 63092552
Liver injury 198.59 14.77 26 300950 60494 63127552
Cerebrovascular accident 198.12 14.77 1024 299952 107000 63081046
Lactose intolerance 197.63 14.77 141 300835 2837 63185209
Back disorder 193.76 14.77 250 300726 10767 63177279
Loss of personal independence in daily activities 193.75 14.77 110 300866 97180 63090866
Blood cholesterol increased 192.06 14.77 103 300873 93929 63094117
Hip arthroplasty 191.23 14.77 8 300968 47638 63140408
Suicidal ideation 188.46 14.77 34 300942 62387 63125659
Decreased appetite 185.93 14.77 1913 299063 249139 62938907
Osteoarthritis 185.32 14.77 111 300865 95232 63092814
Injection site reaction 183.05 14.77 29 300947 58495 63129551
Depressed level of consciousness 180.67 14.77 37 300939 62041 63126005
Atrial fibrillation 179.95 14.77 1055 299921 115581 63072465
Injection site pruritus 179.66 14.77 8 300968 45108 63142938
Hypoaesthesia 179.20 14.77 1389 299587 167004 63021042
Hypersensitivity 178.03 14.77 748 300228 291937 62896109
Injury 176.84 14.77 63 300913 73184 63114862
Abortion spontaneous 176.70 14.77 12 300964 47183 63140863
Injection site swelling 175.50 14.77 13 300963 47559 63140487
Myelodysplastic syndrome transformation 175.13 14.77 69 300907 367 63187679
Anaphylactic reaction 171.70 14.77 50 300926 66050 63121996
Red blood cell sedimentation rate increased 171.28 14.77 9 300967 43973 63144073
Ill-defined disorder 166.31 14.77 90 300886 81665 63106381
General physical health deterioration 165.94 14.77 451 300525 200951 62987095
Medication error 165.59 14.77 25 300951 52259 63135787
Injection site bruising 165.04 14.77 8 300968 41902 63146144
C-reactive protein increased 164.31 14.77 125 300851 94582 63093464
Hyponatraemia 159.40 14.77 177 300799 111723 63076323
Blood pressure systolic increased 158.83 14.77 19 300957 47378 63140668
Coma 157.72 14.77 54 300922 64310 63123736
Renal impairment 157.46 14.77 831 300145 87524 63100522
Disease progression 156.75 14.77 1058 299918 121700 63066346
Clostridium difficile infection 152.51 14.77 396 300580 29526 63158520
Acute lymphocytic leukaemia 150.79 14.77 112 300864 2404 63185642
SARS-CoV-2 test positive 148.28 14.77 187 300789 7869 63180177
Blood magnesium decreased 147.98 14.77 242 300734 12956 63175090
Sedation 147.87 14.77 9 300967 38800 63149246
Dysgeusia 143.80 14.77 518 300458 46192 63141854
Bone pain 143.51 14.77 576 300400 54065 63133981
Prescribed overdose 143.14 14.77 4 300972 34149 63153897
Depression 142.41 14.77 467 300509 196025 62992021
Arthropathy 139.66 14.77 605 300371 234187 62953859
Flatulence 135.48 14.77 417 300559 34285 63153761
Skin exfoliation 134.40 14.77 480 300496 42622 63145424
Upper limb fracture 133.75 14.77 285 300691 18683 63169363
Squamous cell carcinoma of skin 133.53 14.77 155 300821 5977 63182069
Immune system disorder 132.13 14.77 196 300780 9638 63178408
Hypoglycaemia 131.39 14.77 60 300916 60005 63128041
Rhabdomyolysis 130.40 14.77 25 300951 43926 63144120
Premature delivery 128.98 14.77 3 300973 30278 63157768
Joint range of motion decreased 128.30 14.77 6 300970 32422 63155624
Blister 128.17 14.77 264 300712 129550 63058496
Gallbladder disorder 125.88 14.77 277 300699 18565 63169481
Herpes zoster 125.28 14.77 743 300233 81719 63106327
Inflammation 124.05 14.77 124 300852 82149 63105897
Gout 123.41 14.77 224 300752 13047 63174999
Irritable bowel syndrome 123.35 14.77 125 300851 82287 63105759
Dementia 122.97 14.77 274 300702 18520 63169526
Abdominal discomfort 122.14 14.77 955 300021 319930 62868116
Product quality issue 121.11 14.77 14 300962 35851 63152195
Abdominal pain 120.92 14.77 854 300122 292602 62895444
Bronchitis 119.51 14.77 1006 299970 123929 63064117
Obesity 117.04 14.77 6 300970 29946 63158100
COVID-19 pneumonia 116.19 14.77 227 300749 13982 63174064
Blood pressure increased 114.09 14.77 390 300586 161672 63026374
Incorrect dose administered 113.48 14.77 72 300904 59896 63128150
Agitation 112.73 14.77 72 300904 59685 63128361
Electrocardiogram QT prolonged 111.93 14.77 72 300904 59458 63128588
Tumour flare 110.41 14.77 48 300928 340 63187706
Illness 109.33 14.77 492 300484 48567 63139479
Drug withdrawal syndrome 107.69 14.77 5 300971 27189 63160857
Blood creatine phosphokinase increased 107.60 14.77 10 300966 30420 63157626
Bradycardia 107.41 14.77 113 300863 73114 63114932
Sinus disorder 107.20 14.77 307 300669 24246 63163800
Underdose 105.72 14.77 6 300970 27450 63160596
Tremor 104.65 14.77 1022 299954 131217 63056829
Gamma-glutamyltransferase increased 103.89 14.77 18 300958 34013 63154033
Back pain 103.71 14.77 1794 299182 262351 62925695
Interstitial lung disease 103.23 14.77 85 300891 61823 63126223
Pregnancy test false positive 101.40 14.77 38 300938 172 63187874
Pregnancy 101.07 14.77 25 300951 36811 63151235
Drug ineffective for unapproved indication 99.74 14.77 20 300956 34043 63154003
Bone lesion 99.59 14.77 131 300845 5750 63182296
Drug-induced liver injury 98.09 14.77 34 300942 40188 63147858
Musculoskeletal pain 97.72 14.77 180 300796 92097 63095949
Surgery 97.32 14.77 25 300951 35887 63152159
Cardiac failure congestive 96.32 14.77 759 300217 91674 63096372
Blood pressure fluctuation 95.64 14.77 50 300926 46267 63141779
Injection site haemorrhage 94.59 14.77 5 300971 24309 63163737
Incorrect route of product administration 94.50 14.77 10 300966 27442 63160604
Weight increased 94.19 14.77 787 300189 260005 62928041
Joint swelling 92.56 14.77 1050 299926 326616 62861430
Anxiety 92.05 14.77 628 300348 216913 62971133
Live birth 91.76 14.77 8 300968 25622 63162424
Monoclonal immunoglobulin increased 91.37 14.77 32 300944 114 63187932
Paraesthesia 89.83 14.77 1138 299838 155828 63032218
Muscle spasticity 89.72 14.77 3 300973 21791 63166255
Device dislocation 89.43 14.77 9 300967 25696 63162350
Papule 89.09 14.77 122 300854 5569 63182477
Plasma cell myeloma refractory 87.99 14.77 40 300936 319 63187727
Hypercholesterolaemia 87.60 14.77 3 300973 21331 63166715
Emotional distress 87.55 14.77 23 300953 32526 63155520
Drug level increased 87.45 14.77 5 300971 22731 63165315
Cardiac amyloidosis 86.64 14.77 52 300924 770 63187276
Device issue 86.30 14.77 7 300969 23774 63164272
Osteolysis 86.09 14.77 86 300890 2788 63185258
Respiratory arrest 84.21 14.77 25 300951 32620 63155426
Lactic acidosis 84.12 14.77 38 300938 38249 63149797
Eye disorder 83.39 14.77 267 300709 22418 63165628
Coronavirus infection 83.05 14.77 102 300874 4176 63183870
Erythema 82.20 14.77 492 300484 175259 63012787
Metabolic acidosis 81.38 14.77 57 300919 45012 63143034
Pulmonary fibrosis 80.69 14.77 44 300932 39765 63148281
Metastases to liver 80.38 14.77 9 300967 23630 63164416
Blood alkaline phosphatase increased 79.37 14.77 53 300923 42914 63145132
Gait disturbance 78.87 14.77 526 300450 182652 63005394
Chest discomfort 78.48 14.77 263 300713 109706 63078340
Premature baby 78.42 14.77 5 300971 20730 63167316
Product prescribing error 77.89 14.77 15 300961 26274 63161772
Diverticulitis 76.67 14.77 381 300595 39176 63148870
Procedural pain 76.49 14.77 7 300969 21562 63166484
Clostridium difficile colitis 76.43 14.77 243 300733 20326 63167720
Multiple sclerosis 76.38 14.77 12 300964 24360 63163686
Blood pressure diastolic decreased 76.32 14.77 9 300967 22697 63165349
Seizure 76.23 14.77 346 300630 132288 63055758
Grip strength decreased 74.50 14.77 9 300967 22278 63165768
Palpitations 74.27 14.77 279 300697 112491 63075555
Memory impairment 73.96 14.77 788 300188 103470 63084576
Acute leukaemia 73.66 14.77 53 300923 1081 63186965
Amyloidosis 73.62 14.77 53 300923 1082 63186964
Hepatotoxicity 73.54 14.77 42 300934 36999 63151047
Dysarthria 73.26 14.77 57 300919 42654 63145392
Exposure via body fluid 72.90 14.77 42 300934 574 63187472
Hyperkalaemia 72.58 14.77 90 300886 54113 63133933
Pallor 72.57 14.77 27 300949 30541 63157505
Fracture 72.44 14.77 231 300745 19353 63168693
White blood cell count abnormal 72.07 14.77 116 300860 6126 63181920
Compression fracture 71.97 14.77 118 300858 6330 63181716
Oedema peripheral 71.77 14.77 1280 299696 188231 62999815
Swelling face 71.01 14.77 530 300446 62945 63125101
Spinal compression fracture 70.70 14.77 187 300789 14096 63173950
Ascites 70.31 14.77 54 300922 40674 63147372
B precursor type acute leukaemia 70.16 14.77 30 300946 203 63187843
Cardio-respiratory arrest 69.86 14.77 110 300866 59849 63128197
Withdrawal syndrome 69.57 14.77 7 300969 19990 63168056
Eye infection 69.50 14.77 168 300808 11977 63176069
Pulmonary arterial hypertension 68.79 14.77 12 300964 22565 63165481
Somnolence 68.25 14.77 531 300445 178154 63009892
Hypogeusia 68.25 14.77 54 300922 1277 63186769
Hospitalisation 68.15 14.77 193 300783 84888 63103158
Blood iron decreased 68.12 14.77 188 300788 14533 63173513
Dizziness 67.84 14.77 2584 298392 427341 62760705
Bone erosion 67.82 14.77 4 300972 17713 63170333
Pathological fracture 67.27 14.77 137 300839 8697 63179349
Hepatitis 67.11 14.77 54 300922 39734 63148312
Sleep apnoea syndrome 67.06 14.77 27 300949 29106 63158940
Tumour lysis syndrome 66.78 14.77 138 300838 8852 63179194
Nasopharyngitis 66.70 14.77 1627 299349 252630 62935416
Abnormal behaviour 66.13 14.77 11 300965 21415 63166631
Flushing 65.71 14.77 163 300813 74924 63113122
Heart rate increased 65.46 14.77 228 300748 94010 63094036
Hypoacusis 65.33 14.77 257 300719 23894 63164152
Eye swelling 65.09 14.77 255 300721 23663 63164383
Disability 64.94 14.77 6 300970 18341 63169705
Anaphylactic shock 64.91 14.77 16 300960 23617 63164429
Toxic epidermal necrolysis 64.26 14.77 20 300956 25314 63162732
Bursitis 64.08 14.77 49 300927 36992 63151054
Vomiting 64.04 14.77 2094 298882 557523 62630523
Impaired work ability 63.82 14.77 5 300971 17470 63170576
Foot deformity 63.81 14.77 26 300950 27827 63160219
Increased tendency to bruise 63.67 14.77 149 300827 10403 63177643
Generalised tonic-clonic seizure 63.43 14.77 29 300947 28987 63159059
Sleep disorder 63.16 14.77 188 300788 81378 63106668
Feeling abnormal 62.98 14.77 1021 299955 147371 63040675
Insomnia 61.84 14.77 1395 299581 213857 62974189
Drug tolerance decreased 61.09 14.77 6 300970 17467 63170579
Leukaemia 61.09 14.77 87 300889 4121 63183925
Obstructive airways disorder 60.92 14.77 12 300964 20687 63167359
Skin cancer 60.50 14.77 154 300822 11341 63176705
Colitis ulcerative 60.35 14.77 24 300952 26067 63161979
Device malfunction 60.21 14.77 7 300969 17850 63170196
Asthma 60.20 14.77 356 300620 127205 63060841
Stress 60.19 14.77 144 300832 67023 63121023
Metastases to bone 60.18 14.77 13 300963 21006 63167040
Hyperviscosity syndrome 59.12 14.77 25 300951 164 63187882
Rib fracture 57.56 14.77 236 300740 22361 63165685
Accidental exposure to product 57.45 14.77 29 300947 27376 63160670
Body temperature decreased 57.30 14.77 13 300963 20306 63167740
Blood electrolytes decreased 57.29 14.77 47 300929 1172 63186874
Rash macular 57.15 14.77 241 300735 23123 63164923
Prescribed underdose 57.06 14.77 35 300941 29654 63158392
Dysphonia 56.95 14.77 404 300572 47210 63140836
Intraductal proliferative breast lesion 56.82 14.77 70 300906 2875 63185171
Hepatic steatosis 56.58 14.77 33 300943 28736 63159310
Diabetic ketoacidosis 56.09 14.77 14 300962 20491 63167555
Feeling jittery 56.02 14.77 165 300811 13238 63174808
Bone marrow failure 55.98 14.77 281 300695 29009 63159037
Unresponsive to stimuli 55.66 14.77 47 300929 33769 63154277
Dyspnoea 55.02 14.77 2569 298407 658744 62529302
Therapeutic response unexpected 54.95 14.77 11 300965 18748 63169298
Angioedema 54.93 14.77 89 300887 47876 63140170
Transaminases increased 54.90 14.77 41 300935 31326 63156720
Platelet count abnormal 54.00 14.77 73 300903 3291 63184755
Lymphoma 53.80 14.77 153 300823 12034 63176012
Weight decreased 53.67 14.77 1704 299272 275094 62912952
Depressed mood 53.53 14.77 67 300909 40124 63147922
Therapeutic response decreased 53.49 14.77 134 300842 61391 63126655
Dyskinesia 53.27 14.77 44 300932 31958 63156088
Hallucination, visual 53.13 14.77 13 300963 19285 63168761
Dyspnoea exertional 52.68 14.77 131 300845 60171 63127875
Autoimmune disorder 52.62 14.77 9 300967 17168 63170878
Joint stiffness 52.49 14.77 73 300903 41796 63146250
Adenocarcinoma of colon 52.37 14.77 62 300914 2442 63185604
White blood cell disorder 51.77 14.77 62 300914 2472 63185574
Blood pressure abnormal 51.49 14.77 174 300802 15024 63173022
Delirium 51.38 14.77 101 300875 50440 63137606
Sputum discoloured 51.34 14.77 8 300968 16339 63171707
Neuralgia 51.16 14.77 251 300725 25675 63162371
Extrapyramidal disorder 50.85 14.77 3 300973 13281 63174765
Light chain analysis abnormal 50.70 14.77 22 300954 155 63187891
Dystonia 50.33 14.77 4 300972 13815 63174231
Vision blurred 50.25 14.77 661 300315 91263 63096783
Platelet disorder 49.57 14.77 53 300923 1863 63186183
Respiratory syncytial virus infection 48.96 14.77 105 300871 6913 63181133
Fear 48.87 14.77 8 300968 15758 63172288
Coeliac disease 48.65 14.77 3 300973 12794 63175252
Vitamin D decreased 48.58 14.77 132 300844 10110 63177936
Crying 48.48 14.77 25 300951 23318 63164728
Epilepsy 47.85 14.77 35 300941 27030 63161016
Blood calcium abnormal 47.62 14.77 43 300933 1225 63186821
Protein total abnormal 47.53 14.77 29 300947 443 63187603
Blood potassium abnormal 47.47 14.77 60 300916 2530 63185516
Respiratory depression 47.20 14.77 5 300971 13710 63174336
Arthritis 45.89 14.77 341 300635 115580 63072466
Neutrophil count increased 45.76 14.77 11 300965 16516 63171530
Pancreatitis acute 45.65 14.77 37 300939 27129 63160917
Dry eye 45.39 14.77 340 300636 40421 63147625
Rales 45.35 14.77 4 300972 12693 63175353
Myoclonus 45.05 14.77 10 300966 15858 63172188
Poor venous access 44.73 14.77 8 300968 14777 63173269
Therapeutic response shortened 44.56 14.77 3 300973 11885 63176161
Nervousness 44.39 14.77 275 300701 30704 63157342
Liver function test abnormal 44.21 14.77 102 300874 48079 63139967
Product administration error 43.60 14.77 26 300950 22371 63165675
Human chorionic gonadotropin abnormal 43.50 14.77 13 300963 23 63188023
Viral infection 43.47 14.77 304 300672 35359 63152687
Aggression 43.38 14.77 29 300947 23469 63164577
Tachypnoea 43.28 14.77 14 300962 17288 63170758
Device breakage 43.01 14.77 3 300973 11539 63176507
Right ventricular failure 42.83 14.77 14 300962 17174 63170872
Muscle rigidity 42.82 14.77 3 300973 11497 63176549
Drug resistance 42.74 14.77 28 300948 22905 63165141
Middle insomnia 42.52 14.77 5 300971 12638 63175408
Transfusion 42.38 14.77 10 300966 15207 63172839
Iron deficiency anaemia 42.05 14.77 21 300955 19948 63168098
International normalised ratio increased 42.02 14.77 99 300877 46326 63141720
Oral disorder 41.89 14.77 114 300862 8740 63179306
Eczema 41.80 14.77 55 300921 32236 63155810
Heavy menstrual bleeding 41.68 14.77 16 300960 17757 63170289
Failure to thrive 41.65 14.77 100 300876 7098 63180948
Tooth infection 41.64 14.77 182 300794 17738 63170308
Leukocytosis 41.53 14.77 37 300939 25898 63162148
Product storage error 41.32 14.77 10 300966 14946 63173100
No adverse event 41.01 14.77 84 300892 41321 63146725
Confusional state 40.98 14.77 832 300144 235548 62952498
B-cell type acute leukaemia 40.91 14.77 20 300956 191 63187855
Skin hyperpigmentation 40.63 14.77 88 300888 5833 63182213
Impaired quality of life 40.54 14.77 8 300968 13775 63174271
Anhedonia 40.47 14.77 3 300973 10971 63177075
Disease complication 40.33 14.77 62 300914 3147 63184899
Complication associated with device 40.29 14.77 15 300961 16963 63171083
Haematemesis 40.19 14.77 51 300925 30361 63157685
Cyanosis 40.13 14.77 15 300961 16920 63171126
Vitamin B12 decreased 40.07 14.77 66 300910 3554 63184492
Gastrointestinal motility disorder 39.71 14.77 80 300896 5039 63183007
Hypothermia 39.70 14.77 8 300968 13573 63174473
Upper respiratory tract infection 39.57 14.77 577 300399 81470 63106576
Transformation to acute myeloid leukaemia 39.55 14.77 21 300955 242 63187804
Localised infection 39.49 14.77 262 300714 29948 63158098
Skin necrosis 39.19 14.77 9 300967 13941 63174105
Blood calcium increased 38.97 14.77 115 300861 9235 63178811
Pneumonia influenzal 38.81 14.77 44 300932 1653 63186393
Cellulitis 38.60 14.77 574 300402 81384 63106662
Affect lability 38.54 14.77 4 300972 11147 63176899
Invasive ductal breast carcinoma 38.49 14.77 95 300881 6863 63181183
Coagulopathy 38.40 14.77 25 300951 20519 63167527
Metastases to lung 38.36 14.77 7 300969 12743 63175303
Cholecystitis chronic 37.73 14.77 3 300973 10358 63177688
Liver function test decreased 37.63 14.77 13 300963 44 63188002
Uveitis 37.53 14.77 7 300969 12546 63175500
Sinus tachycardia 37.23 14.77 36 300940 24232 63163814
Nail discolouration 37.22 14.77 55 300921 2695 63185351
Hypokinesia 37.19 14.77 10 300966 13926 63174120
Chronic sinusitis 36.65 14.77 8 300968 12835 63175211
Nerve injury 36.49 14.77 117 300859 9829 63178217
Injection site rash 36.39 14.77 22 300954 18787 63169259
Hyperlipidaemia 36.33 14.77 24 300952 19547 63168499
Peripheral venous disease 36.19 14.77 14 300962 15463 63172583
Hypothyroidism 36.17 14.77 94 300882 42538 63145508
Blood urea increased 36.16 14.77 43 300933 26336 63161710
Acute hepatic failure 36.07 14.77 21 300955 18306 63169740
Melaena 36.05 14.77 55 300921 30310 63157736
Muscle strain 35.67 14.77 103 300873 8171 63179875
Parkinsonism 35.43 14.77 4 300972 10435 63177611
Blood bilirubin increased 35.40 14.77 77 300899 37063 63150983
Uterine disorder 35.38 14.77 58 300918 3111 63184935
Pulmonary hypertension 35.35 14.77 77 300899 37046 63151000
Encephalopathy 35.24 14.77 82 300894 38538 63149508
Psychotic disorder 35.15 14.77 42 300934 25670 63162376
Osteoporosis 35.10 14.77 146 300830 57192 63130854
Refractory cytopenia with multilineage dysplasia 34.73 14.77 16 300960 132 63187914
Blood magnesium abnormal 34.72 14.77 27 300949 622 63187424
Abortion induced 34.57 14.77 4 300972 10238 63177808
Transplant rejection 34.49 14.77 5 300971 10775 63177271
Joint effusion 34.36 14.77 19 300957 17041 63171005
Angina pectoris 34.26 14.77 56 300920 30022 63158024
Respiratory rate increased 34.21 14.77 11 300965 13637 63174409
Speech disorder 34.15 14.77 90 300886 40539 63147507
Spinal disorder 34.10 14.77 114 300862 9788 63178258
Colitis 34.03 14.77 366 300610 48162 63139884
Malignant neoplasm of unknown primary site 33.99 14.77 20 300956 285 63187761
Breast cancer female 33.86 14.77 11 300965 13548 63174498
Altered state of consciousness 33.66 14.77 42 300934 25188 63162858
Mucosal inflammation 33.62 14.77 112 300864 46816 63141230
Blood pressure diastolic increased 33.56 14.77 4 300972 10006 63178040
Rhinorrhoea 33.55 14.77 466 300510 65111 63122935
Coronary artery disease 33.52 14.77 64 300912 32313 63155733
Endometrial adenocarcinoma 33.42 14.77 35 300941 1201 63186845
Red cell distribution width increased 33.39 14.77 5 300971 10519 63177527
Ovarian cyst 33.23 14.77 17 300959 15928 63172118
Hepatic cirrhosis 33.18 14.77 41 300935 24693 63163353
Hypoxia 33.13 14.77 158 300818 59634 63128412
Torsade de pointes 33.05 14.77 11 300965 13340 63174706
Pigmentation disorder 33.04 14.77 70 300906 4569 63183477
Pelvic fracture 32.89 14.77 138 300838 13210 63174836
Myositis 32.88 14.77 3 300973 9263 63178783
Ear swelling 32.78 14.77 38 300938 1463 63186583
Large intestine infection 32.69 14.77 43 300933 1887 63186159
Respiratory distress 32.68 14.77 70 300906 33881 63154165
Cardiac arrest 32.57 14.77 281 300695 92264 63095782
Peripheral coldness 32.53 14.77 129 300847 12036 63176010
Dermatitis atopic 32.32 14.77 4 300972 9720 63178326
Hepatocellular injury 32.11 14.77 50 300926 27331 63160715
Status epilepticus 32.11 14.77 16 300960 15217 63172829
Myalgia 31.98 14.77 495 300481 146034 63042012
Transient ischaemic attack 31.92 14.77 296 300680 37457 63150589
Deformity 31.91 14.77 8 300968 11676 63176370
Food poisoning 31.76 14.77 66 300910 4250 63183796
Post procedural complication 31.61 14.77 21 300955 17053 63170993
Hypercalcaemia 31.39 14.77 236 300740 28086 63159960
Protein total decreased 31.38 14.77 80 300896 5897 63182149
Blood calcium decreased 31.37 14.77 224 300752 26227 63161819
Adverse event 31.36 14.77 472 300504 67087 63120959
Hysterectomy 31.35 14.77 4 300972 9495 63178551
Red blood cell count abnormal 31.18 14.77 32 300944 1072 63186974
Breath sounds abnormal 30.98 14.77 7 300969 10966 63177080
Schizophrenia 30.96 14.77 5 300971 9947 63178099
Accidental overdose 30.89 14.77 39 300937 23270 63164776
Colon cancer 30.78 14.77 110 300866 9768 63178278
White blood cell count 30.65 14.77 13 300963 86 63187960
Urinary retention 30.41 14.77 61 300915 30240 63157806
Rhinitis allergic 30.21 14.77 9 300967 11718 63176328
Pneumonia aspiration 30.19 14.77 75 300901 34465 63153581
Febrile infection 30.03 14.77 37 300939 1520 63186526
Neurotoxicity 30.00 14.77 22 300954 16968 63171078
Circulatory collapse 29.82 14.77 36 300940 21902 63166144
Cholecystectomy 29.77 14.77 7 300969 10670 63177376
Incorrect product administration duration 29.49 14.77 9 300967 11537 63176509
Agranulocytosis 29.38 14.77 46 300930 25088 63162958
Osteonecrosis of jaw 29.01 14.77 274 300702 34849 63153197
Upper gastrointestinal haemorrhage 28.88 14.77 28 300948 18824 63169222
Diabetes mellitus inadequate control 28.83 14.77 18 300958 15108 63172938
Shock haemorrhagic 28.57 14.77 6 300970 9889 63178157
Bronchiectasis 28.37 14.77 21 300955 16121 63171925
Shock 28.33 14.77 42 300934 23421 63164625
Scar 28.27 14.77 15 300961 13767 63174279
Oedema 28.21 14.77 311 300665 97311 63090735
Motor dysfunction 28.20 14.77 8 300968 10753 63177293
Muscular weakness 28.19 14.77 409 300567 121944 63066102
Pneumonia pneumococcal 28.12 14.77 43 300933 2172 63185874
Walking aid user 28.02 14.77 8 300968 10709 63177337
Metastases to lymph nodes 28.01 14.77 3 300973 8155 63179891
Performance status decreased 27.96 14.77 57 300919 3621 63184425
Ejection fraction decreased 27.93 14.77 39 300937 22293 63165753
Mitral valve incompetence 27.87 14.77 31 300945 19563 63168483
Hemiparesis 27.80 14.77 42 300934 23240 63164806
Precursor B-lymphoblastic lymphoma 27.63 14.77 9 300967 24 63188022
Hallucination 27.46 14.77 150 300826 54667 63133379
Spinal osteoarthritis 27.25 14.77 22 300954 16164 63171882
Photophobia 27.24 14.77 26 300950 17609 63170437
Cardiogenic shock 27.05 14.77 27 300949 17905 63170141
Hepatic failure 27.01 14.77 83 300893 35573 63152473
Coordination abnormal 26.80 14.77 16 300960 13757 63174289
Jaundice 26.77 14.77 62 300914 29189 63158857
Hepatic encephalopathy 26.72 14.77 10 300966 11272 63176774
Injection site discolouration 26.65 14.77 3 300973 7845 63180201
Blood immunoglobulin A increased 26.53 14.77 25 300951 753 63187293
Proteinuria 26.46 14.77 31 300945 19114 63168932
Tuberculosis 26.45 14.77 10 300966 11201 63176845
Haematoma 26.42 14.77 81 300895 34739 63153307
Oral pain 26.25 14.77 227 300749 28167 63159879
Malignant melanoma 26.13 14.77 115 300861 11241 63176805
Gastritis 26.06 14.77 90 300886 37213 63150833
Hypotonia 26.06 14.77 6 300970 9279 63178767
Ventricular tachycardia 25.89 14.77 34 300942 19945 63168101
Pancreatitis 25.82 14.77 132 300844 48923 63139123
Body temperature increased 25.80 14.77 90 300886 37102 63150944
Cholestasis 25.66 14.77 64 300912 29370 63158676
Paraproteinaemia 25.66 14.77 14 300962 171 63187875
Maternal exposure before pregnancy 25.59 14.77 3 300973 7600 63180446
Fluid retention 25.41 14.77 411 300565 59275 63128771
Monocyte count increased 25.11 14.77 3 300973 7490 63180556
Infusion site extravasation 25.10 14.77 9 300967 10417 63177629
Panic attack 25.04 14.77 42 300934 22289 63165757
Breast cancer 24.82 14.77 344 300632 48039 63140007
Cushingoid 24.80 14.77 5 300971 8480 63179566
Refractory anaemia with an excess of blasts 24.80 14.77 19 300957 428 63187618
Delusion 24.76 14.77 13 300963 12004 63176042
Haematotoxicity 24.73 14.77 99 300877 9277 63178769
Feeding disorder 24.69 14.77 127 300849 13235 63174811
Lacrimation increased 24.63 14.77 175 300801 20456 63167590
Neutrophil count abnormal 24.62 14.77 47 300929 2845 63185201
Optic neuritis 24.59 14.77 5 300971 8430 63179616
Miosis 24.50 14.77 3 300973 7350 63180696
Metastases to central nervous system 24.42 14.77 16 300960 13089 63174957
N-terminal prohormone brain natriuretic peptide decreased 24.38 14.77 8 300968 22 63188024
White blood cell count increased 24.26 14.77 133 300843 48428 63139618
Deafness 24.24 14.77 157 300819 17800 63170246
Gingival bleeding 24.22 14.77 121 300855 12466 63175580
Ventricular fibrillation 24.22 14.77 13 300963 11854 63176192
Aphasia 24.17 14.77 78 300898 32922 63155124
Pain in jaw 24.06 14.77 115 300861 43381 63144665
Chalazion 23.93 14.77 18 300958 394 63187652
Spinal operation 23.91 14.77 5 300971 8266 63179780
Blood immunoglobulin G increased 23.89 14.77 42 300934 2385 63185661
Parainfluenzae virus infection 23.86 14.77 41 300935 2286 63185760
Blood triglycerides increased 23.61 14.77 15 300961 12473 63175573
Myocardial ischaemia 23.56 14.77 16 300960 12843 63175203
Hyperproteinaemia 23.35 14.77 11 300965 96 63187950
Glycosylated haemoglobin increased 23.29 14.77 15 300961 12383 63175663
Oesophageal squamous cell carcinoma 23.24 14.77 12 300964 130 63187916
Tricuspid valve incompetence 23.24 14.77 21 300955 14600 63173446
Left ventricular dysfunction 23.22 14.77 14 300962 11974 63176072
Bone density decreased 23.21 14.77 21 300955 14591 63173455
Intentional dose omission 23.11 14.77 5 300971 8070 63179976
Plasma cell myeloma in remission 23.09 14.77 6 300970 4 63188042
Muscle twitching 22.99 14.77 36 300940 19632 63168414
Traumatic fracture 22.91 14.77 22 300954 679 63187367
Blood lactate dehydrogenase increased 22.80 14.77 47 300929 23069 63164977
Bone disorder 22.68 14.77 176 300800 21150 63166896
Post procedural haemorrhage 22.65 14.77 5 300971 7959 63180087
Atelectasis 22.65 14.77 42 300934 21441 63166605
Anuria 22.49 14.77 16 300960 12535 63175511
Rectal adenocarcinoma 22.44 14.77 21 300955 627 63187419
Hair growth abnormal 22.42 14.77 46 300930 2935 63185111
Polyarthritis 22.39 14.77 10 300966 10136 63177910
Movement disorder 22.26 14.77 43 300933 21618 63166428
Productive cough 22.20 14.77 192 300784 63016 63125030
Gingival pain 22.19 14.77 87 300889 8075 63179971
Hallucination, auditory 22.13 14.77 17 300959 12807 63175239
Chest pain 22.07 14.77 819 300157 215140 62972906
POEMS syndrome 21.95 14.77 7 300969 17 63188029
Pseudomonas infection 21.85 14.77 13 300963 11200 63176846
Full blood count 21.78 14.77 5 300971 0 63188046
Hot flush 21.68 14.77 352 300624 50807 63137239
Orthostatic hypotension 21.56 14.77 93 300883 36067 63151979
Mouth ulceration 21.45 14.77 82 300894 32902 63155144
Myeloma cast nephropathy 21.32 14.77 11 300965 119 63187927
Angina unstable 21.12 14.77 4 300972 7091 63180955
Pneumococcal sepsis 21.07 14.77 21 300955 679 63187367
Acute kidney injury 21.05 14.77 1027 299949 262388 62925658
Anosmia 21.04 14.77 76 300900 6784 63181262
Female genital tract fistula 20.99 14.77 5 300971 7554 63180492
Colitis microscopic 20.94 14.77 9 300967 9330 63178716
Chondrocalcinosis pyrophosphate 20.77 14.77 27 300949 1171 63186875
Kidney infection 20.76 14.77 184 300792 22992 63165054
Hyperglycaemia 20.73 14.77 115 300861 41752 63146294
Gastrointestinal infection 20.61 14.77 93 300883 9188 63178858
Nodule 20.53 14.77 43 300933 20983 63167063
Amnesia 20.49 14.77 374 300602 55211 63132835
Superficial spreading melanoma stage unspecified 20.40 14.77 11 300965 131 63187915
Infection 20.36 14.77 1303 299673 227870 62960176
Skin plaque 20.34 14.77 7 300969 8313 63179733
Fistula 20.32 14.77 12 300964 10381 63177665
Dyslipidaemia 20.31 14.77 5 300971 7388 63180658
Breast cancer stage II 20.26 14.77 8 300968 8728 63179318
Balance disorder 20.25 14.77 534 300442 83888 63104158
Low density lipoprotein increased 20.22 14.77 3 300973 6354 63181692
Hypoaesthesia oral 20.14 14.77 118 300858 12915 63175131
Pemphigoid 20.11 14.77 5 300971 7339 63180707
Vascular device infection 19.98 14.77 5 300971 7307 63180739
Lipase increased 19.98 14.77 11 300965 9889 63178157
Gastrointestinal fungal infection 19.69 14.77 15 300961 335 63187711
Gastrooesophageal reflux disease 19.55 14.77 327 300649 95312 63092734
Asphyxia 19.47 14.77 3 300973 6178 63181868
Nasal abscess 19.46 14.77 12 300964 187 63187859
Tardive dyskinesia 19.37 14.77 8 300968 8494 63179552
Malignant melanoma in situ 19.36 14.77 23 300953 909 63187137
Restlessness 19.29 14.77 73 300903 29380 63158666
Crepitations 19.25 14.77 7 300969 8033 63180013
Sarcoidosis 19.21 14.77 5 300971 7117 63180929
Apnoea 19.18 14.77 7 300969 8015 63180031
Major depression 19.17 14.77 7 300969 8011 63180035
Viral upper respiratory tract infection 19.14 14.77 80 300896 7644 63180402
Onychoclasis 19.14 14.77 69 300907 6153 63181893
Blood lactic acid increased 19.07 14.77 5 300971 7081 63180965
Bronchospasm 18.92 14.77 33 300943 17247 63170799
Adrenal insufficiency 18.91 14.77 35 300941 17880 63170166
Diarrhoea haemorrhagic 18.89 14.77 89 300887 8953 63179093
Intermenstrual bleeding 18.81 14.77 7 300969 7919 63180127
Haemoglobin abnormal 18.80 14.77 60 300916 5028 63183018
Acute generalised exanthematous pustulosis 18.79 14.77 15 300961 11084 63176962
Product distribution issue 18.70 14.77 28 300948 1388 63186658
Sinus bradycardia 18.61 14.77 25 300951 14526 63173520
Ataxia 18.54 14.77 27 300949 15168 63172878
Oliguria 18.53 14.77 10 300966 9091 63178955
Blood pressure systolic decreased 18.48 14.77 6 300970 7391 63180655
Gastrointestinal haemorrhage 18.47 14.77 272 300704 80904 63107142
Cytogenetic abnormality 18.32 14.77 17 300959 502 63187544
Cerebellar haemangioma 18.23 14.77 9 300967 88 63187958
Genital haemorrhage 18.22 14.77 6 300970 7326 63180720
Nightmare 18.12 14.77 40 300936 19154 63168892
Throat tightness 18.10 14.77 59 300917 24828 63163218
Intestinal obstruction 18.06 14.77 225 300751 30674 63157372
Immunoglobulins increased 17.92 14.77 16 300960 449 63187597
Body dysmorphic disorder 17.73 14.77 14 300962 330 63187716
Physical deconditioning 17.72 14.77 21 300955 828 63187218
Orthopnoea 17.67 14.77 4 300972 6257 63181789
Nystagmus 17.50 14.77 4 300972 6216 63181830
Oral herpes 17.49 14.77 64 300912 26010 63162036
Vaginal discharge 17.46 14.77 11 300965 9187 63178859
Ear discomfort 17.39 14.77 79 300897 7827 63180219
Influenza like illness 17.33 14.77 218 300758 66606 63121440
Renal function test abnormal 17.25 14.77 47 300929 3606 63184440
Gastroenteritis viral 17.20 14.77 180 300796 23520 63164526
Hypertransaminasaemia 17.16 14.77 5 300971 6604 63181442
Vertebral lesion 17.04 14.77 18 300958 624 63187422
Toxic encephalopathy 17.04 14.77 5 300971 6574 63181472
Swollen tongue 17.00 14.77 96 300880 34704 63153342
Stress cardiomyopathy 16.99 14.77 12 300964 9438 63178608
Exposure to toxic agent 16.95 14.77 3 300973 5584 63182462
Blood iron increased 16.91 14.77 28 300948 1514 63186532
Clavicle fracture 16.86 14.77 45 300931 3410 63184636
Bradyphrenia 16.85 14.77 6 300970 6974 63181072
Limb discomfort 16.78 14.77 215 300761 29501 63158545
Cervical vertebral fracture 16.78 14.77 38 300938 2596 63185450
Device occlusion 16.75 14.77 7 300969 7380 63180666
Cataract operation 16.68 14.77 3 300973 5519 63182527
Haemodialysis 16.57 14.77 11 300965 8936 63179110
Osteopenia 16.49 14.77 44 300932 19741 63168305
Pulmonary sepsis 16.46 14.77 28 300948 1548 63186498
Vasculitis 16.34 14.77 39 300937 18170 63169876
Auditory disorder 16.31 14.77 17 300959 580 63187466
Hypercapnia 16.30 14.77 3 300973 5428 63182618
Joint dislocation 16.29 14.77 41 300935 18759 63169287
Hepatic function abnormal 16.29 14.77 106 300870 37036 63151010
Marasmus 16.26 14.77 16 300960 509 63187537
Disturbance in attention 16.24 14.77 110 300866 38079 63149967
Exostosis 16.23 14.77 38 300938 17824 63170222
Blood pressure decreased 16.17 14.77 214 300762 64808 63123238
Hydronephrosis 16.14 14.77 16 300960 10646 63177400
Hypersensitivity myocarditis 16.14 14.77 11 300965 205 63187841
Wound infection 16.10 14.77 50 300926 21360 63166686
Amenorrhoea 16.05 14.77 14 300962 9900 63178146
Tubulointerstitial nephritis 16.04 14.77 45 300931 19858 63168188
Target skin lesion 16.01 14.77 9 300967 117 63187929
Sensory disturbance 16 14.77 25 300951 13647 63174399
Peritonitis 15.99 14.77 36 300940 17118 63170928
Arteriosclerosis coronary artery 15.91 14.77 10 300966 8363 63179683
Eosinophil count increased 15.87 14.77 17 300959 10911 63177135
Varicophlebitis 15.86 14.77 6 300970 28 63188018
Bipolar disorder 15.84 14.77 9 300967 7951 63180095
Personality disorder 15.83 14.77 4 300972 5807 63182239
Respiratory acidosis 15.82 14.77 6 300970 6709 63181337
Lung disorder 15.82 14.77 204 300772 62057 63125989
Vitamin D deficiency 15.70 14.77 26 300950 13866 63174180
Mood swings 15.66 14.77 40 300936 18208 63169838
Brain oedema 15.64 14.77 27 300949 14168 63173878
Bundle branch block left 15.51 14.77 7 300969 7052 63180994
Intracranial pressure increased 15.45 14.77 3 300973 5224 63182822
Arteriosclerosis 15.36 14.77 15 300961 10051 63177995
Gingival swelling 15.33 14.77 51 300925 4367 63183679
Tendonitis 15.33 14.77 45 300931 19570 63168476
Wrong product administered 15.30 14.77 5 300971 6136 63181910
Bradykinesia 15.28 14.77 3 300973 5185 63182861
Pneumothorax 15.26 14.77 34 300942 16227 63171819
Adenocarcinoma pancreas 15.23 14.77 22 300954 1056 63186990
Irritability 15.18 14.77 88 300888 31606 63156440
Blood test 15.17 14.77 5 300971 14 63188032
Basal cell carcinoma 15.17 14.77 201 300775 27790 63160256
Polyuria 15.16 14.77 11 300965 8531 63179515
White blood cells urine positive 15.16 14.77 3 300973 5155 63182891
Bone marrow myelogram abnormal 15.06 14.77 6 300970 33 63188013
Sensitive skin 15.06 14.77 29 300947 1767 63186279
Bowel movement irregularity 15.04 14.77 57 300919 5207 63182839
Encephalitis 15.04 14.77 12 300964 8868 63179178
Subarachnoid haemorrhage 14.99 14.77 28 300948 14255 63173791
Vitiligo 14.94 14.77 25 300951 1364 63186682
Abdominal pain upper 14.90 14.77 1154 299822 205290 62982756
Activated partial thromboplastin time prolonged 14.89 14.77 7 300969 6886 63181160
Uterine leiomyoma 14.87 14.77 13 300963 9185 63178861
Decubitus ulcer 14.83 14.77 93 300883 10427 63177619
Knee operation 14.80 14.77 5 300971 6008 63182038
Device failure 14.80 14.77 5 300971 6006 63182040

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Death 5606.01 14.79 11081 283957 386968 34274925
Full blood count decreased 4891.32 14.79 2585 292453 15503 34646390
Neuropathy peripheral 3583.37 14.79 3946 291092 79317 34582576
Thrombosis 3467.72 14.79 3088 291950 47370 34614523
Rash 3283.42 14.79 6342 288696 216410 34445483
White blood cell count decreased 3202.40 14.79 3981 291057 91464 34570429
Pneumonia 2841.29 14.79 8053 286985 354574 34307319
Fatigue 2837.26 14.79 8162 286876 362491 34299402
Laboratory test abnormal 2496.72 14.79 1755 293283 18636 34643257
Platelet count decreased 2468.65 14.79 3956 291082 115761 34546132
Diarrhoea 2068.71 14.79 7582 287456 382330 34279563
Adverse drug reaction 1715.06 14.79 1642 293396 27700 34634193
Unevaluable event 1704.17 14.79 1716 293322 30874 34631019
Drug interaction 1506.00 14.79 104 294934 225842 34436051
Plasma cell myeloma 1431.33 14.79 1769 293269 40268 34621625
Constipation 1345.27 14.79 3319 291719 133663 34528230
Muscle spasms 1325.93 14.79 2316 292722 72685 34589208
Deep vein thrombosis 1135.00 14.79 2001 293037 63247 34598646
Plasma cell myeloma recurrent 973.24 14.79 554 294484 3911 34657982
Drug abuse 806.95 14.79 5 295033 99091 34562802
Condition aggravated 793.79 14.79 315 294723 191881 34470012
Peripheral swelling 785.44 14.79 1888 293150 74653 34587240
Tooth disorder 755.81 14.79 671 294367 10211 34651682
COVID-19 740.67 14.79 1861 293177 75689 34586204
Product dose omission issue 734.05 14.79 2450 292588 117261 34544632
Cardiac disorder 729.33 14.79 1307 293731 41819 34620074
Completed suicide 671.41 14.79 39 294999 98129 34563764
Neutropenia 645.43 14.79 2826 292212 153952 34507941
Overdose 553.84 14.79 61 294977 90998 34570895
Drug ineffective 553.76 14.79 1992 293046 454759 34207134
Renal disorder 547.76 14.79 860 294178 24620 34637273
Product use in unapproved indication 526.57 14.79 168 294870 117331 34544562
Rash pruritic 520.13 14.79 866 294172 26075 34635818
Pulmonary thrombosis 512.89 14.79 456 294582 6951 34654942
Ageusia 506.01 14.79 525 294513 9783 34652110
Red blood cell count decreased 490.84 14.79 881 294157 28209 34633684
Pancytopenia 422.35 14.79 1756 293282 93401 34568492
Pulmonary embolism 416.36 14.79 1679 293359 88067 34573826
Squamous cell carcinoma of skin 409.22 14.79 482 294556 10399 34651494
Plasmacytoma 406.22 14.79 298 294740 3393 34658500
Influenza 401.71 14.79 1121 293917 48545 34613348
Full blood count abnormal 399.68 14.79 629 294409 18039 34643854
Asthenia 384.11 14.79 3447 291591 241804 34420089
Acute kidney injury 371.19 14.79 1326 293712 303662 34358231
Alanine aminotransferase increased 364.69 14.79 114 294924 80701 34581192
Neutrophil count decreased 355.37 14.79 1093 293945 50011 34611882
Rhabdomyolysis 354.10 14.79 72 294966 68091 34593802
Intentional overdose 351.40 14.79 3 295035 43671 34618222
Drug intolerance 351.02 14.79 1204 293834 58366 34603527
Off label use 345.70 14.79 2103 292935 417421 34244472
Aspartate aminotransferase increased 335.12 14.79 80 294958 67703 34594190
Blood test abnormal 333.10 14.79 350 294688 6621 34655272
Thrombocytopenia 332.32 14.79 2357 292681 153890 34508003
Intentional product misuse 328.15 14.79 13 295025 45598 34616295
Myelodysplastic syndrome 321.75 14.79 580 294458 18628 34643265
Cytopenia 308.12 14.79 454 294584 12269 34649624
Tachycardia 307.47 14.79 166 294872 84606 34577287
Back disorder 303.74 14.79 326 294712 6325 34655568
Taste disorder 299.48 14.79 335 294703 6820 34655073
Adverse event 293.51 14.79 552 294486 18325 34643568
Abdominal pain 291.13 14.79 589 294449 163029 34498864
Inappropriate schedule of product administration 289.89 14.79 83 294955 62213 34599680
Cataract 285.59 14.79 662 294376 25524 34636369
Pruritus 284.64 14.79 2112 292926 139869 34522024
Hip fracture 283.71 14.79 422 294616 11503 34650390
Nasopharyngitis 281.63 14.79 1254 293784 68714 34593179
Injection site pain 280.99 14.79 11 295027 38994 34622899
Hyponatraemia 279.92 14.79 176 294862 82515 34579378
Infection 278.43 14.79 1507 293531 89408 34572485
Hyperkalaemia 275.79 14.79 120 294918 69269 34592624
Blood creatine phosphokinase increased 275.30 14.79 29 295009 44828 34617065
Suicide attempt 275.26 14.79 13 295025 39103 34622790
Rheumatoid arthritis 264.96 14.79 14 295024 38224 34623669
Light chain analysis increased 263.46 14.79 158 294880 1243 34660650
Hypoaesthesia 261.57 14.79 1120 293918 60324 34601569
Bradycardia 261.56 14.79 156 294882 75262 34586631
Gallbladder disorder 261.39 14.79 299 294739 6243 34655650
Vomiting 259.30 14.79 1142 293896 246479 34415414
Body height decreased 258.93 14.79 233 294805 3610 34658283
Acute myeloid leukaemia 256.86 14.79 512 294526 17758 34644135
Hypoglycaemia 253.86 14.79 73 294965 54567 34607326
Wrong technique in product usage process 249.90 14.79 13 295025 35973 34625920
Hiccups 238.72 14.79 356 294682 9726 34652167
Depressed level of consciousness 235.91 14.79 39 294999 42802 34619091
Haemoglobin decreased 234.30 14.79 1783 293255 118989 34542904
Full blood count increased 232.26 14.79 124 294914 758 34661135
Seasonal allergy 231.83 14.79 284 294754 6391 34655502
Hypertension 230.18 14.79 506 294532 135937 34525956
Herpes zoster 229.14 14.79 725 294313 33674 34628219
Coma 227.54 14.79 53 294985 45625 34616268
Blood potassium decreased 224.71 14.79 479 294559 17436 34644457
Metabolic acidosis 216.95 14.79 51 294987 43629 34618264
Protein total increased 212.69 14.79 167 294871 2120 34659773
Blood pressure increased 206.59 14.79 264 294774 87838 34574055
Agitation 205.75 14.79 114 294924 57285 34604608
Lactic acidosis 204.58 14.79 26 295012 34746 34627147
Headache 203.43 14.79 936 294102 199699 34462194
Suicidal ideation 202.89 14.79 46 294992 40342 34621551
Spinal fracture 202.75 14.79 282 294756 7216 34654677
Plasma cell leukaemia 199.99 14.79 115 294923 829 34661064
Ascites 199.03 14.79 72 294966 46499 34615394
Seizure 196.30 14.79 366 294672 104491 34557402
Monoclonal immunoglobulin present 196.29 14.79 117 294921 909 34660984
Dry skin 193.55 14.79 643 294395 30644 34631249
Aggression 190.56 14.79 47 294991 38917 34622976
C-reactive protein increased 188.81 14.79 111 294927 53987 34607906
Interstitial lung disease 182.51 14.79 169 294869 65113 34596780
Gastric disorder 180.11 14.79 353 294685 12088 34649805
Incorrect dose administered 179.41 14.79 59 294979 40456 34621437
Multiple allergies 177.02 14.79 169 294869 2834 34659059
Renal failure 174.88 14.79 1777 293261 128780 34533113
Electrocardiogram QT prolonged 172.16 14.79 65 294973 40887 34621006
Oxygen saturation decreased 170.72 14.79 123 294915 53695 34608198
Therapeutic product effect incomplete 169.02 14.79 109 294929 50432 34611461
Acute lymphocytic leukaemia 166.42 14.79 164 294874 2865 34659028
Product use issue 165.93 14.79 173 294865 63043 34598850
Drug level increased 163.45 14.79 5 295033 22091 34639802
Hernia 162.54 14.79 291 294747 9292 34652601
Psoriasis 162.49 14.79 62 294976 38750 34623143
Contraindicated product administered 162.10 14.79 4 295034 21477 34640416
Bronchitis 161.19 14.79 742 294296 41221 34620672
Back pain 160.38 14.79 1652 293386 120137 34541756
Wheezing 156.10 14.79 77 294961 41325 34620568
Psoriatic arthropathy 152.08 14.79 3 295035 19795 34642098
General physical health deterioration 151.94 14.79 563 294475 127706 34534187
Skin cancer 151.29 14.79 294 294744 10003 34651890
Illness 147.44 14.79 342 294696 13187 34648706
Premature baby 146.85 14.79 4 295034 19629 34642264
Basal cell carcinoma 145.53 14.79 430 294608 19228 34642665
Arthropathy 144.74 14.79 528 294510 26379 34635514
Skin discolouration 144.36 14.79 403 294635 17442 34644451
Sedation 141.51 14.79 9 295029 20997 34640896
Cardio-respiratory arrest 140.89 14.79 155 294883 55118 34606775
Melaena 140.82 14.79 61 294977 35319 34626574
Drug-induced liver injury 140.55 14.79 35 295003 28797 34633096
Lactose intolerance 139.82 14.79 104 294934 1211 34660682
Anaphylactic reaction 137.90 14.79 50 294988 32251 34629642
Product prescribing error 137.68 14.79 16 295022 22911 34638982
Medication error 136.95 14.79 25 295013 25540 34636353
Fall 136.26 14.79 2437 292601 200448 34461445
Gamma-glutamyltransferase increased 135.84 14.79 39 294999 29192 34632701
Drug ineffective for unapproved indication 134.14 14.79 20 295018 23695 34638198
International normalised ratio increased 134.07 14.79 121 294917 47206 34614687
Haematuria 133.66 14.79 135 294903 49931 34611962
Blood pressure systolic increased 133 14.79 18 295020 22934 34638959
Bone pain 130.48 14.79 428 294610 20258 34641635
Spinal disorder 130.34 14.79 170 294868 4082 34657811
Angioedema 128.55 14.79 78 294960 37296 34624597
Dysarthria 127.66 14.79 67 294971 34715 34627178
Blood alkaline phosphatase increased 126.88 14.79 52 294986 31123 34630770
Swelling face 126.48 14.79 456 294582 22649 34639244
Pallor 126.02 14.79 30 295008 25450 34636443
Drug hypersensitivity 121.88 14.79 316 294722 80213 34581680
Generalised tonic-clonic seizure 121.76 14.79 17 295021 21157 34640736
Cholestasis 121.51 14.79 38 295000 26910 34634983
Localised infection 121.06 14.79 375 294663 17212 34644681
Depression 119.70 14.79 419 294619 96679 34565214
Immune system disorder 118.78 14.79 179 294859 4936 34656957
Gout 118.44 14.79 395 294643 18858 34643035
Respiratory arrest 117.04 14.79 45 294993 27998 34633895
Abnormal behaviour 116.61 14.79 33 295005 24936 34636957
Gastrointestinal haemorrhage 116.47 14.79 371 294667 88106 34573787
Dehydration 115.79 14.79 1637 293401 128332 34533561
Myelodysplastic syndrome transformation 115.58 14.79 61 294977 363 34661530
Psychotic disorder 114.78 14.79 32 295006 24420 34637473
Anxiety 114.72 14.79 441 294597 98987 34562906
Obstructive airways disorder 112.85 14.79 4 295034 15490 34646403
Respiratory depression 112.36 14.79 6 295032 16239 34645654
Cardiogenic shock 112.28 14.79 42 294996 26576 34635317
Upper limb fracture 110.98 14.79 167 294871 4599 34657294
Asthma 110.49 14.79 118 294920 42538 34619355
Transaminases increased 110.37 14.79 44 294994 26779 34635114
Hepatocellular injury 110.14 14.79 26 295012 22185 34639708
Compression fracture 109.47 14.79 132 294906 2920 34658973
Mucosal inflammation 107.89 14.79 100 294938 38522 34623371
Hallucination, visual 107.87 14.79 12 295026 17779 34644114
Incorrect route of product administration 107.54 14.79 4 295034 14841 34647052
Multiple organ dysfunction syndrome 107.23 14.79 312 294726 76254 34585639
Blood urea increased 106.35 14.79 62 294976 30302 34631591
Acute leukaemia 105.78 14.79 84 294954 1085 34660808
Hepatic function abnormal 104.90 14.79 132 294906 44231 34617662
Disease progression 103.88 14.79 1380 293658 106697 34555196
Myoclonus 103.24 14.79 5 295033 14720 34647173
SARS-CoV-2 test positive 102.97 14.79 182 294856 5751 34656142
Drug resistance 102.70 14.79 45 294993 25882 34636011
Tumour flare 102.54 14.79 73 294965 790 34661103
Ventricular fibrillation 102.37 14.79 33 295005 22921 34638972
Intentional self-injury 102.28 14.79 3 295035 13768 34648125
Product quality issue 102.01 14.79 12 295026 17023 34644870
Upper gastrointestinal haemorrhage 101.54 14.79 44 294994 25474 34636419
Loss of personal independence in daily activities 101.13 14.79 79 294959 33100 34628793
Somnolence 100.57 14.79 539 294499 110577 34551316
Adenocarcinoma of colon 99.96 14.79 133 294905 3258 34658635
Hypoxia 99.80 14.79 196 294842 54899 34606994
Hordeolum 99.73 14.79 78 294960 984 34660909
Stress 99.34 14.79 67 294971 30280 34631613
Hospitalisation 98.33 14.79 208 294830 56694 34605199
Pathological fracture 98.20 14.79 151 294887 4240 34657653
Blood bilirubin increased 98.01 14.79 107 294931 38189 34623704
Diabetic ketoacidosis 97.96 14.79 17 295021 18015 34643878
Rib fracture 96.30 14.79 304 294734 14096 34647797
Prostatic disorder 96.25 14.79 130 294908 3232 34658661
Sinus tachycardia 95.12 14.79 16 295022 17344 34644549
Extrapyramidal disorder 94.96 14.79 3 295035 12877 34649016
B precursor type acute leukaemia 94.93 14.79 43 294995 172 34661721
Hallucination 94.32 14.79 182 294856 51316 34610577
Eye disorder 94.26 14.79 232 294806 9296 34652597
Tubulointerstitial nephritis 94.16 14.79 30 295008 20994 34640899
Dysgeusia 94.05 14.79 458 294580 26039 34635854
Emotional distress 94.03 14.79 9 295029 15017 34646876
Cardiac arrest 93.50 14.79 455 294583 95704 34566189
Dyskinesia 93.48 14.79 36 295002 22377 34639516
Musculoskeletal disorder 93.42 14.79 179 294859 6025 34655868
Bone disorder 93.19 14.79 179 294859 6036 34655857
Treatment failure 91.80 14.79 158 294880 46539 34615354
Delirium 90.98 14.79 144 294894 43847 34618046
Erythema 89.88 14.79 414 294624 88366 34573527
Underdose 89.65 14.79 7 295031 13773 34648120
Plasma cell myeloma refractory 89.61 14.79 59 294979 556 34661337
Hepatic failure 88.90 14.79 96 294942 34435 34627458
Leukocytosis 88.84 14.79 46 294992 24019 34637874
Unresponsive to stimuli 88.74 14.79 62 294976 27507 34634386
Ventricular tachycardia 87.92 14.79 58 294980 26521 34635372
Spinal compression fracture 87.76 14.79 189 294849 6927 34654966
Atrial fibrillation 87.32 14.79 1485 293553 120908 34540985
Pancreatitis acute 87.04 14.79 66 294972 28075 34633818
Encephalopathy 86.77 14.79 102 294936 35217 34626676
Anaphylactic shock 86.66 14.79 15 295023 15926 34645967
Synovitis 86.52 14.79 9 295029 14057 34647836
Accidental overdose 86.26 14.79 31 295007 20109 34641784
Pancreatitis 85.57 14.79 122 294916 38769 34623124
Hypercalcaemia 85.26 14.79 306 294732 15162 34646731
Blood pressure fluctuation 85.02 14.79 54 294984 25195 34636698
Osteonecrosis of jaw 84.62 14.79 337 294701 17552 34644341
Hypoacusis 84.40 14.79 316 294722 15985 34645908
Chest discomfort 83.23 14.79 213 294825 54317 34607576
Colitis ulcerative 82.59 14.79 19 295019 16501 34645392
Blood calcium increased 82.36 14.79 125 294913 3469 34658424
Mobility decreased 81.82 14.79 80 294958 30048 34631845
Malignant melanoma 81.11 14.79 198 294840 7892 34654001
Pregnancy of partner 81.00 14.79 45 294993 301 34661592
Injection site swelling 80.54 14.79 4 295034 11523 34650370
Status epilepticus 80.43 14.79 7 295031 12607 34649286
Palpitations 79.78 14.79 134 294904 39852 34622041
Bone lesion 79.45 14.79 111 294927 2852 34659041
Decreased appetite 79.40 14.79 1901 293137 164491 34497402
Paranoia 78.88 14.79 6 295032 12062 34649831
Agranulocytosis 78.77 14.79 52 294986 23769 34638124
Gastrointestinal disorder 78.34 14.79 523 294515 33425 34628468
Shock 78.32 14.79 54 294984 24125 34637768
Joint swelling 78.05 14.79 811 294227 59079 34602814
Monoclonal immunoglobulin increased 78.04 14.79 35 295003 136 34661757
Obesity 77.29 14.79 9 295029 12869 34649024
Fluid retention 76.37 14.79 437 294601 26450 34635443
Tachypnoea 75.67 14.79 30 295008 18322 34643571
Muscle rigidity 75.62 14.79 3 295035 10515 34651378
Epilepsy 75.12 14.79 44 294994 21451 34640442
Circulatory collapse 75.04 14.79 42 294996 20996 34640897
Increased tendency to bruise 74.94 14.79 128 294910 3933 34657960
Infusion related reaction 74.41 14.79 216 294822 52841 34609052
White blood cell count abnormal 74.34 14.79 113 294925 3140 34658753
Hypokalaemia 73.88 14.79 248 294790 57966 34603927
Insomnia 73.83 14.79 1260 293778 102647 34559246
Hepatotoxicity 73.65 14.79 45 294993 21440 34640453
Cerebral infarction 73.30 14.79 74 294964 27381 34634512
Sinusitis 72.83 14.79 598 294440 40804 34621089
Haematemesis 72.49 14.79 76 294962 27635 34634258
Jaundice 72.15 14.79 98 294940 31784 34630109
Fear 72.05 14.79 4 295034 10472 34651421
Arteriosclerosis coronary artery 71.84 14.79 10 295028 12475 34649418
Altered state of consciousness 71.69 14.79 53 294985 22840 34639053
Coronary artery disease 71.19 14.79 192 294846 48113 34613780
Anaemia 70.69 14.79 2518 292520 230817 34431076
Hepatitis 70.25 14.79 59 294979 23845 34638048
Paraesthesia 69.96 14.79 839 294199 63333 34598560
Hemiparesis 69.80 14.79 23 295015 15755 34646138
Cyanosis 69.41 14.79 12 295026 12752 34649141
Hepatic encephalopathy 69.33 14.79 19 295019 14666 34647227
Withdrawal syndrome 69.31 14.79 11 295027 12444 34649449
Hypomagnesaemia 69.19 14.79 50 294988 21801 34640092
Neutrophil count increased 69.12 14.79 29 295009 17117 34644776
Malignant neoplasm of unknown primary site 69.11 14.79 43 294995 364 34661529
Brain oedema 68.88 14.79 16 295022 13805 34648088
Hepatic steatosis 67.92 14.79 35 295003 18327 34643566
Nerve injury 67.80 14.79 113 294925 3402 34658491
Transplant rejection 67.75 14.79 5 295033 10306 34651587
Sleep apnoea syndrome 67.68 14.79 44 294994 20277 34641616
Cerebrovascular accident 67.52 14.79 1048 293990 83763 34578130
Dementia 67.46 14.79 262 294776 13486 34648407
Liver function test abnormal 66.86 14.79 99 294939 30975 34630918
Sinus disorder 66.40 14.79 169 294869 6916 34654977
Sepsis 66.06 14.79 1857 293181 164704 34497189
Cytomegalovirus infection 65.79 14.79 74 294964 26061 34635832
White blood cell count increased 65.72 14.79 157 294881 40994 34620899
Surgery 65.57 14.79 19 295019 14138 34647755
Restlessness 65.42 14.79 71 294967 25411 34636482
Toxic epidermal necrolysis 65.38 14.79 52 294986 21594 34640299
Hyperhidrosis 65.26 14.79 373 294665 75319 34586574
Leukaemia 64.68 14.79 129 294909 4474 34657419
Vitamin B12 decreased 64.56 14.79 66 294972 1207 34660686
Delusion 64.23 14.79 14 295024 12621 34649272
Respiratory failure 64.15 14.79 596 294442 107976 34553917
Blood triglycerides increased 63.77 14.79 20 295018 14139 34647754
Product administration error 63.74 14.79 29 295009 16315 34645578
White blood cell disorder 63.43 14.79 74 294964 1579 34660314
Coronavirus infection 63.30 14.79 123 294915 4184 34657709
Light chain analysis abnormal 62.79 14.79 28 295010 107 34661786
Neurotoxicity 62.75 14.79 37 295001 17973 34643920
Injection site erythema 62.33 14.79 28 295010 15871 34646022
Myositis 62.12 14.79 13 295025 12057 34649836
Respiratory distress 61.91 14.79 130 294908 35535 34626358
Rectal haemorrhage 61.58 14.79 157 294881 40092 34621801
Feeling abnormal 61.34 14.79 809 294229 62426 34599467
Body temperature decreased 61.28 14.79 17 295021 13017 34648876
Swelling 61.14 14.79 586 294452 41780 34620113
Device malfunction 60.79 14.79 8 295030 10413 34651480
Blood calcium decreased 60.34 14.79 205 294833 9879 34652014
Prescribed overdose 60.16 14.79 9 295029 10638 34651255
Accidental exposure to product 59.62 14.79 17 295021 12785 34649108
Hyperlipidaemia 59.50 14.79 24 295014 14505 34647388
Dystonia 59.40 14.79 10 295028 10835 34651058
Coagulopathy 59.19 14.79 48 294990 19741 34642152
Disseminated intravascular coagulation 59.15 14.79 58 294980 21758 34640135
Haemodynamic instability 58.81 14.79 6 295032 9517 34652376
Acute respiratory distress syndrome 58.58 14.79 80 294958 25889 34636004
Proteinuria 58.58 14.79 43 294995 18599 34643294
Blood lactate dehydrogenase increased 57.98 14.79 65 294973 22925 34638968
Haematoma 56.64 14.79 80 294958 25525 34636368
Depressed mood 56.37 14.79 48 294990 19269 34642624
Platelet disorder 56.19 14.79 71 294967 1650 34660243
Pathogen resistance 55.98 14.79 7 295031 9475 34652418
Acidosis 55.90 14.79 12 295026 10933 34650960
Injection site haemorrhage 55.79 14.79 8 295030 9760 34652133
Hallucination, auditory 55.18 14.79 16 295022 11901 34649992
Abdominal discomfort 54.95 14.79 758 294280 59077 34602816
Flushing 54.75 14.79 120 294918 32300 34629593
Injection site bruising 54.71 14.79 5 295033 8658 34653235
Exposure during pregnancy 54.23 14.79 6 295032 8928 34652965
Protein total abnormal 54.21 14.79 35 295003 318 34661575
Pulmonary hypertension 54.04 14.79 58 294980 20866 34641027
Inappropriate antidiuretic hormone secretion 53.99 14.79 20 295018 12733 34649160
Diabetes mellitus inadequate control 53.91 14.79 23 295015 13441 34648452
Metastases to liver 53.66 14.79 24 295014 13639 34648254
Inflammation 53.56 14.79 98 294940 28197 34633696
Urinary tract infection 53.47 14.79 1002 294036 83079 34578814
Cardiomegaly 53.38 14.79 32 295006 15406 34646487
Hepatic cytolysis 53.07 14.79 28 295010 14468 34647425
Hypercholesterolaemia 52.89 14.79 6 295032 8756 34653137
Hypogeusia 52.82 14.79 52 294986 907 34660986
Dyspnoea exertional 52.46 14.79 188 294850 43091 34618802
Confusional state 52.45 14.79 878 294160 143282 34518611
Pneumonia aspiration 52.14 14.79 180 294858 41723 34620170
Venoocclusive liver disease 51.95 14.79 4 295034 7962 34653931
Balance disorder 51.76 14.79 548 294490 40106 34621787
Uveitis 51.44 14.79 3 295035 7532 34654361
Memory impairment 51.05 14.79 575 294463 42743 34619150
Lipase increased 50.88 14.79 9 295029 9407 34652486
Vitamin D decreased 50.76 14.79 99 294939 3377 34658516
Haematochezia 50.71 14.79 211 294827 46323 34615570
Gynaecomastia 50.31 14.79 12 295026 10168 34651725
Rales 50.14 14.79 11 295027 9872 34652021
Blood albumin decreased 50.01 14.79 26 295012 13546 34648347
Schizophrenia 49.72 14.79 7 295031 8659 34653234
Chest pain 49.45 14.79 762 294276 126000 34535893
B-cell type acute leukaemia 49.27 14.79 32 295006 294 34661599
Tooth infection 49.05 14.79 147 294891 6624 34655269
Disturbance in attention 48.98 14.79 90 294948 25855 34636038
Mitral valve incompetence 48.89 14.79 33 295005 14910 34646983
Metastases to bone 48.65 14.79 20 295018 11950 34649943
Blood pressure diastolic decreased 48.47 14.79 9 295029 9085 34652808
Blood creatinine increased 48.40 14.79 540 294498 94436 34567457
Toxicity to various agents 48.38 14.79 1304 293734 199058 34462835
Subarachnoid haemorrhage 48.37 14.79 23 295015 12612 34649281
Renal injury 48.34 14.79 17 295021 11178 34650715
Dyslipidaemia 48.17 14.79 4 295034 7484 34654409
Left ventricular hypertrophy 48.00 14.79 6 295032 8124 34653769
Adverse reaction 47.55 14.79 89 294949 2942 34658951
Therapeutic response unexpected 47.25 14.79 12 295026 9745 34652148
Acute myocardial infarction 47.22 14.79 263 294775 53456 34608437
Hepatic cirrhosis 46.98 14.79 46 294992 17268 34644625
Aplastic anaemia 46.95 14.79 12 295026 9704 34652189
Lower limb fracture 46.74 14.79 106 294932 4025 34657868
Hyperbilirubinaemia 46.57 14.79 44 294994 16799 34645094
Injection site reaction 46.51 14.79 26 295012 13007 34648886
Angina unstable 46.51 14.79 20 295018 11633 34650260
Blood pressure decreased 46.50 14.79 250 294788 51265 34610628
Myocarditis 46.42 14.79 29 295009 13653 34648240
Pulmonary fibrosis 46.40 14.79 52 294986 18344 34643549
Myocardial ischaemia 46.37 14.79 47 294991 17361 34644532
Acute hepatic failure 46.16 14.79 31 295007 14043 34647850
Blood loss anaemia 46.13 14.79 7 295031 8187 34653706
Torsade de pointes 45.96 14.79 4 295034 7205 34654688
Angina pectoris 45.95 14.79 125 294913 31238 34630655
Cerebral haemorrhage 45.58 14.79 147 294891 34790 34627103
Activated partial thromboplastin time prolonged 45.51 14.79 9 295029 8686 34653207
Injury 45.39 14.79 65 294973 20622 34641271
Type 2 diabetes mellitus 45.37 14.79 41 294997 15991 34645902
Hypothermia 45.26 14.79 17 295021 10731 34651162
Blood electrolytes decreased 45.03 14.79 33 295005 375 34661518
Arthralgia 44.95 14.79 1092 293946 168949 34492944
Blood phosphorus increased 44.86 14.79 6 295032 7715 34654178
Shock haemorrhagic 44.50 14.79 20 295018 11334 34650559
Hypotension 44.48 14.79 1479 293559 220170 34441723
Anuria 44.45 14.79 16 295022 10369 34651524
Drug reaction with eosinophilia and systemic symptoms 44.40 14.79 137 294901 32875 34629018
Dry eye 44.18 14.79 179 294859 9396 34652497
Joint range of motion decreased 44.15 14.79 5 295033 7307 34654586
Myalgia 44.13 14.79 475 294563 83635 34578258
Duodenal ulcer 44.08 14.79 16 295022 10316 34651577
Haemoptysis 43.81 14.79 150 294888 34856 34627037
Impaired work ability 43.76 14.79 4 295034 6926 34654967
Toothache 43.76 14.79 136 294902 6252 34655641
Hypertriglyceridaemia 43.68 14.79 9 295029 8439 34653454
Breath sounds abnormal 43.38 14.79 4 295034 6877 34655016
Respiratory tract congestion 43.26 14.79 132 294906 6007 34655886
Ejection fraction decreased 43.21 14.79 59 294979 19095 34642798
Posterior reversible encephalopathy syndrome 43.18 14.79 15 295023 9939 34651954
Clostridium difficile infection 42.90 14.79 290 294748 18608 34643285
Dysphonia 42.88 14.79 341 294697 23042 34638851
Disease recurrence 42.88 14.79 72 294966 21418 34640475
Respiratory rate increased 42.76 14.79 15 295023 9879 34652014
Aphasia 42.69 14.79 72 294966 21382 34640511
Blood pressure abnormal 42.68 14.79 158 294880 7948 34653945
Speech disorder 42.62 14.79 96 294942 25590 34636303
COVID-19 pneumonia 42.57 14.79 267 294771 16700 34645193
Vertebral lesion 42.39 14.79 25 295013 190 34661703
Metastases to lung 42.27 14.79 13 295025 9307 34652586
Jaw disorder 42.06 14.79 70 294968 2105 34659788
Glomerular filtration rate decreased 41.90 14.79 29 295009 12932 34648961
Anhedonia 41.53 14.79 7 295031 7578 34654315
Basosquamous carcinoma of skin 41.26 14.79 12 295026 5 34661888
Eosinophilia 41.11 14.79 101 294937 26121 34635772
Kidney transplant rejection 40.87 14.79 7 295031 7490 34654403
Auditory disorder 40.87 14.79 27 295011 256 34661637
Femur fracture 40.82 14.79 156 294882 7968 34653925
Blood immunoglobulin G increased 40.72 14.79 45 294993 903 34660990
Haemodialysis 40.54 14.79 19 295019 10507 34651386
Knee arthroplasty 40.47 14.79 7 295031 7437 34654456
Upper respiratory tract infection 40.40 14.79 442 294596 32617 34629276
Skin exfoliation 40.34 14.79 381 294657 27051 34634842
No adverse event 40.27 14.79 83 294955 22844 34639049
Febrile neutropenia 40.05 14.79 865 294173 135984 34525909
Hepatitis cholestatic 40.00 14.79 9 295029 7938 34653955
Electrocardiogram abnormal 40.00 14.79 14 295024 9233 34652660
Ataxia 39.72 14.79 35 295003 13818 34648075
Rhinorrhoea 39.51 14.79 360 294678 25308 34636585
Product storage error 39.31 14.79 10 295028 8112 34653781
Oliguria 39.26 14.79 11 295027 8369 34653524
Haemorrhage intracranial 39.22 14.79 46 294992 15900 34645993
Hypokinesia 39.18 14.79 13 295025 8867 34653026
Heart rate increased 39.06 14.79 230 294808 46113 34615780
Fracture 39.03 14.79 137 294901 6712 34655181
Myasthenia gravis 38.91 14.79 6 295032 6934 34654959
Renal tubular necrosis 38.81 14.79 45 294993 15635 34646258
Left ventricular dysfunction 38.64 14.79 18 295020 9989 34651904
Mania 38.48 14.79 16 295022 9495 34652398
Cardiac amyloidosis 38.32 14.79 50 294988 1201 34660692
Muscle spasticity 38.28 14.79 3 295035 5885 34656008
Pulmonary arterial hypertension 38.20 14.79 13 295025 8726 34653167
Blood iron decreased 38.16 14.79 115 294923 5198 34656695
Asphyxia 38.11 14.79 6 295032 6829 34655064
Post transplant lymphoproliferative disorder 38.10 14.79 5 295033 6523 34655370
Dizziness 38.03 14.79 2230 292808 216291 34445602
Neutrophil count abnormal 37.83 14.79 62 294976 1840 34660053
Refractory anaemia with an excess of blasts 37.81 14.79 30 295008 387 34661506
Disorientation 37.72 14.79 148 294890 33040 34628853
Parkinsonism 37.54 14.79 11 295027 8127 34653766
Renal impairment 37.47 14.79 1054 293984 93459 34568434
Chills 37.35 14.79 471 294567 80572 34581321
Rash macular 37.30 14.79 210 294828 12632 34649261
Sputum discoloured 37.08 14.79 10 295028 7802 34654091
Osteolysis 36.99 14.79 82 294956 3066 34658827
Productive cough 36.67 14.79 179 294859 37634 34624259
Hypertensive crisis 36.58 14.79 14 295024 8737 34653156
Lower gastrointestinal haemorrhage 36.50 14.79 17 295021 9435 34652458
Hyperthermia 36.46 14.79 22 295016 10555 34651338
Limb discomfort 36.40 14.79 187 294851 10860 34651033
Iron deficiency anaemia 36.29 14.79 21 295017 10308 34651585
Dysphagia 36.15 14.79 344 294694 62037 34599856
Bronchospasm 36.05 14.79 23 295015 10708 34651185
Contusion 35.99 14.79 467 294571 35897 34625996
Device dislocation 35.97 14.79 5 295033 6244 34655649
Cardiac failure congestive 35.96 14.79 939 294099 82331 34579562
Coordination abnormal 35.88 14.79 10 295028 7634 34654259
Nephropathy toxic 35.85 14.79 32 295006 12556 34649337
Hepatic enzyme increased 35.63 14.79 189 294849 38891 34623002
Hypotonia 35.53 14.79 11 295027 7842 34654051
Treatment noncompliance 35.44 14.79 120 294918 27980 34633913
Cardiac valve disease 35.27 14.79 80 294958 3038 34658855
Peritonitis bacterial 34.91 14.79 5 295033 6105 34655788
Eye infection 34.82 14.79 88 294950 3585 34658308
Sinus bradycardia 34.53 14.79 35 295003 12928 34648965
Oral disorder 34.40 14.79 96 294942 4153 34657740
Bronchiectasis 34.33 14.79 20 295018 9781 34652112
Platelet count abnormal 34.20 14.79 76 294962 2846 34659047
Subdural haematoma 34.14 14.79 76 294962 20345 34641548
Oesophagitis 33.98 14.79 37 295001 13224 34648669
Dyspnoea 33.97 14.79 2729 292309 374053 34287840
Wrong product administered 33.90 14.79 3 295035 5331 34656562
Nightmare 33.82 14.79 43 294995 14348 34647545
Pleural effusion 33.57 14.79 485 294553 81061 34580832
Eye swelling 33.49 14.79 170 294868 9825 34652068
Chondrocalcinosis pyrophosphate 33.45 14.79 41 294997 923 34660970
Glycosylated haemoglobin increased 33.42 14.79 28 295010 11332 34650561
Pneumonia influenzal 33.40 14.79 52 294986 1476 34660417
Tumour marker increased 33.12 14.79 34 295004 625 34661268
Viral infection 32.86 14.79 258 294780 17365 34644528
Tricuspid valve incompetence 32.68 14.79 21 295017 9739 34652154
Hepatomegaly 32.64 14.79 24 295014 10372 34651521
Multiple fractures 32.56 14.79 50 294988 1402 34660491
Lacrimation increased 32.55 14.79 150 294888 8332 34653561
Pneumonitis 32.49 14.79 161 294877 33717 34628176
Hydronephrosis 32.33 14.79 24 295014 10322 34651571
Transfusion 32.30 14.79 16 295022 8569 34653324
Product distribution issue 32.27 14.79 34 295004 645 34661248
Eosinophil count increased 32.21 14.79 16 295022 8556 34653337
Osteoarthritis 31.97 14.79 80 294958 20562 34641331
Adrenal insufficiency 31.96 14.79 43 294995 14004 34647889
Granulocytopenia 31.95 14.79 8 295030 6559 34655334
Red blood cell count abnormal 31.94 14.79 34 295004 653 34661240
Hypovolaemic shock 31.92 14.79 10 295028 7075 34654818
Hyperviscosity syndrome 31.80 14.79 21 295017 199 34661694
Therapy non-responder 31.61 14.79 485 294553 38661 34623232
Tendonitis 31.53 14.79 19 295019 9121 34652772
Inflammatory marker increased 31.49 14.79 3 295035 5025 34656868
Clavicle fracture 31.47 14.79 61 294977 2071 34659822
Gastritis 31.43 14.79 88 294950 21785 34640108
Visual acuity reduced 31.40 14.79 55 294983 16094 34645799
Euphoric mood 31.35 14.79 5 295033 5636 34656257
Atelectasis 31.28 14.79 64 294974 17663 34644230
Injection site pruritus 31.20 14.79 10 295028 6973 34654920
Enterococcal infection 31.19 14.79 20 295018 9286 34652607
Motor dysfunction 31.14 14.79 10 295028 6964 34654929
Aphonia 31.13 14.79 80 294958 3293 34658600
Respiratory tract infection 31.12 14.79 278 294760 19434 34642459
Hypothyroidism 30.85 14.79 83 294955 20819 34641074
Adenovirus infection 30.75 14.79 4 295034 5253 34656640
Red cell distribution width increased 30.69 14.79 7 295031 6116 34655777
Right ventricular failure 30.66 14.79 18 295020 8766 34653127
Multiple sclerosis 30.62 14.79 9 295029 6636 34655257
Limb injury 30.61 14.79 186 294852 11503 34650390
Eczema 30.50 14.79 69 294969 18367 34643526
Systemic infection 30.40 14.79 4 295034 5208 34656685
Blood magnesium decreased 30.37 14.79 121 294917 6302 34655591
Lymphocyte count decreased 30.34 14.79 94 294944 22528 34639365
Exercise tolerance decreased 30.29 14.79 4 295034 5194 34656699
Viral upper respiratory tract infection 30.22 14.79 70 294968 2696 34659197
Hyperglycaemia 30.14 14.79 202 294836 39278 34622615
Paraproteinaemia 30.13 14.79 25 295013 345 34661548
Cholangitis 30.06 14.79 18 295020 8671 34653222
Post procedural complication 30.04 14.79 31 295007 11357 34650536
Pneumonia viral 30.04 14.79 76 294962 3098 34658795
Abdominal pain lower 29.95 14.79 27 295011 10544 34651349
Appendix disorder 29.80 14.79 32 295006 621 34661272
Acute respiratory failure 29.65 14.79 147 294891 30781 34631112
Atrial flutter 29.59 14.79 229 294809 15345 34646548
Blood lactic acid increased 29.42 14.79 10 295028 6718 34655175
POEMS syndrome 29.31 14.79 12 295026 35 34661858
Gastritis erosive 29.30 14.79 7 295031 5925 34655968
Pseudomonas infection 29.10 14.79 37 295001 12345 34649548
Klebsiella infection 29.05 14.79 18 295020 8513 34653380
Monocyte count increased 28.82 14.79 3 295035 4684 34657209
Skin necrosis 28.72 14.79 7 295031 5846 34656047
Liver injury 28.63 14.79 51 294987 14827 34647066
Rectal adenocarcinoma 28.38 14.79 35 295003 793 34661100
Electrocardiogram ST segment elevation 28.31 14.79 5 295033 5233 34656660
Skin plaque 28.25 14.79 3 295035 4611 34657282
Enthesopathy 28.25 14.79 3 295035 4610 34657283
Pelvic fracture 28.08 14.79 65 294973 2502 34659391
Flatulence 28.04 14.79 288 294750 20910 34640983
Pneumothorax 28.03 14.79 76 294962 19016 34642877
Weight decreased 28.00 14.79 1785 293253 174516 34487377
Coronary artery stenosis 27.92 14.79 24 295014 9592 34652301
Dialysis 27.92 14.79 32 295006 11176 34650717
Tenosynovitis 27.91 14.79 3 295035 4567 34657326
Hyperthyroidism 27.61 14.79 29 295009 10537 34651356
Cardiac failure 27.48 14.79 574 294464 90674 34571219
Lymphocytic leukaemia 27.48 14.79 18 295020 168 34661725
Arthropod bite 27.36 14.79 68 294970 2741 34659152
Hepatitis acute 27.36 14.79 15 295023 7586 34654307
Orthopnoea 27.31 14.79 5 295033 5098 34656795
Stent placement 27.12 14.79 5 295033 5073 34656820
Partial seizures 26.95 14.79 4 295034 4756 34657137
Hypophosphataemia 26.91 14.79 32 295006 10994 34650899
Amyloidosis 26.88 14.79 57 294981 2066 34659827
Refractory cytopenia with multilineage dysplasia 26.87 14.79 16 295022 124 34661769
Cellulitis 26.73 14.79 610 294428 52341 34609552
Prothrombin time prolonged 26.68 14.79 24 295014 9382 34652511
Spinal cord compression 26.65 14.79 84 294954 3891 34658002
Middle insomnia 26.63 14.79 12 295026 6790 34655103
Pulse absent 26.49 14.79 8 295030 5795 34656098
Peritonitis 26.47 14.79 62 294976 16303 34645590
Blood immunoglobulin A increased 26.43 14.79 22 295016 305 34661588
Alanine aminotransferase abnormal 26.40 14.79 4 295034 4684 34657209
Colon cancer 26.39 14.79 143 294895 8478 34653415
Urinary incontinence 26.33 14.79 77 294961 18797 34643096
Hiatus hernia 26.22 14.79 16 295022 7629 34654264
Hypernatraemia 26.14 14.79 20 295018 8470 34653423
Epstein-Barr virus infection 26.11 14.79 16 295022 7612 34654281
Musculoskeletal chest pain 26.09 14.79 158 294880 9760 34652133
Palmar-plantar erythrodysaesthesia syndrome 26.08 14.79 65 294973 16730 34645163
Discomfort 25.89 14.79 78 294960 18860 34643033
Amylase increased 25.87 14.79 9 295029 5959 34655934
Behaviour disorder 25.87 14.79 5 295033 4905 34656988
Cerebral haematoma 25.85 14.79 4 295034 4611 34657282
Coronary artery bypass 25.81 14.79 5 295033 4897 34656996
Hepatic fibrosis 25.79 14.79 4 295034 4603 34657290
Pulmonary congestion 25.76 14.79 48 294990 13717 34648176
Apnoea 25.71 14.79 12 295026 6652 34655241
Metastases to central nervous system 25.68 14.79 19 295019 8186 34653707
Sternal fracture 25.68 14.79 30 295008 641 34661252
Hypercapnia 25.47 14.79 3 295035 4252 34657641
Aspergillus infection 25.43 14.79 40 294998 12214 34649679
Brain injury 25.39 14.79 10 295028 6132 34655761
Ketoacidosis 25.37 14.79 3 295035 4240 34657653
Congestive cardiomyopathy 25.36 14.79 16 295022 7494 34654399
Hyperammonaemia 25.29 14.79 11 295027 6356 34655537
Myeloma cast nephropathy 25.23 14.79 12 295026 55 34661838
Skin atrophy 25.06 14.79 55 294983 2042 34659851
Atrioventricular block first degree 25.05 14.79 10 295028 6082 34655811
Blood cholesterol increased 25.04 14.79 89 294949 20454 34641439
Post procedural haemorrhage 24.92 14.79 20 295018 8269 34653624
Oesophageal carcinoma 24.92 14.79 25 295013 9279 34652614
Ventricular hypokinesia 24.72 14.79 8 295030 5544 34656349
Myopathy 24.67 14.79 37 295001 11517 34650376
Musculoskeletal pain 24.67 14.79 163 294875 31800 34630093
Panic attack 24.52 14.79 26 295012 9406 34652487
Bladder disorder 24.18 14.79 72 294966 3232 34658661
Necrosis 24.18 14.79 9 295029 5714 34656179
Chronic kidney disease 23.97 14.79 227 294811 40983 34620910
Autoimmune hepatitis 23.92 14.79 4 295034 4356 34657537
Renal tubular disorder 23.90 14.79 5 295033 4638 34657255
Migraine 23.88 14.79 72 294966 17406 34644487
Gingival pain 23.77 14.79 68 294970 2984 34658909
Malignant melanoma in situ 23.77 14.79 48 294990 1680 34660213
Papule 23.77 14.79 83 294955 4056 34657837
Ventricular hypertrophy 23.63 14.79 5 295033 4602 34657291
Bone erosion 23.62 14.79 3 295035 4012 34657881
Night sweats 23.55 14.79 237 294801 17115 34644778
Gait disturbance 23.50 14.79 543 294495 84597 34577296
Dermatitis allergic 23.47 14.79 117 294921 6713 34655180
Device occlusion 23.44 14.79 13 295025 6532 34655361
Salivary hypersecretion 23.41 14.79 23 295015 8621 34653272
Malignant neoplasm progression 23.34 14.79 565 294473 87481 34574412
Aspiration 23.28 14.79 42 294996 12152 34649741
Cholecystitis infective 23.19 14.79 50 294988 1834 34660059
Type 1 diabetes mellitus 23.16 14.79 4 295034 4254 34657639
Intracranial pressure increased 23.15 14.79 3 295035 3952 34657941
Gastroenteritis viral 23.06 14.79 120 294918 7004 34654889
Bradyphrenia 23.04 14.79 6 295032 4792 34657101
Respiratory acidosis 22.98 14.79 7 295031 5043 34656850
Muscle twitching 22.95 14.79 32 295006 10266 34651627
Central nervous system lesion 22.91 14.79 13 295025 6450 34655443
Visceral leishmaniasis 22.82 14.79 27 295011 585 34661308
Prescribed underdose 22.80 14.79 25 295013 8908 34652985
Neuralgia 22.77 14.79 211 294827 14902 34646991
Bundle branch block left 22.71 14.79 11 295027 5968 34655925
Toxic encephalopathy 22.61 14.79 8 295030 5241 34656652
Spinal osteoarthritis 22.53 14.79 19 295019 7664 34654229
Ischaemic cardiomyopathy 22.43 14.79 13 295025 6376 34655517
Skin sensitisation 22.38 14.79 18 295020 237 34661656
Splenomegaly 22.33 14.79 60 294978 15057 34646836
Lentigo maligna 22.24 14.79 21 295017 347 34661546
Blood test 22.20 14.79 7 295031 6 34661887
Muscle strain 22.20 14.79 79 294959 3897 34657996
Lip swelling 22.14 14.79 66 294972 16014 34645879
Blood chloride decreased 22.07 14.79 3 295035 3810 34658083
Haemolytic anaemia 21.94 14.79 34 295004 10445 34651448
Hepatic necrosis 21.92 14.79 3 295035 3791 34658102
Chronic graft versus host disease 21.92 14.79 5 295033 4368 34657525
Anger 21.75 14.79 42 294996 11842 34650051
Cardiomyopathy 21.73 14.79 71 294967 16737 34645156
Portal hypertension 21.69 14.79 4 295034 4058 34657835
Presyncope 21.65 14.79 85 294953 18974 34642919
Weight fluctuation 21.63 14.79 94 294944 5091 34656802
Sickle cell anaemia with crisis 21.62 14.79 4 295034 4049 34657844
Erectile dysfunction 21.60 14.79 95 294943 20542 34641351
Salmonellosis 21.59 14.79 34 295004 975 34660918
Duodenitis 21.42 14.79 7 295031 4821 34657072
Diverticulum intestinal 21.39 14.79 4 295034 4017 34657876
Nausea 21.30 14.79 2528 292510 337380 34324513
Brain herniation 21.29 14.79 4 295034 4004 34657889
Musculoskeletal stiffness 21.23 14.79 272 294766 46408 34615485
Polyarthritis 21.20 14.79 6 295032 4534 34657359
5q minus syndrome 21.17 14.79 14 295024 133 34661760
Dermatitis acneiform 21.16 14.79 13 295025 6176 34655717
Cardiac tamponade 21.07 14.79 9 295029 5257 34656636
Benign prostatic hyperplasia 21.06 14.79 58 294980 14437 34647456
Urticaria 21.04 14.79 682 294356 61695 34600198
Oral infection 20.90 14.79 51 294987 2032 34659861
Therapy partial responder 20.90 14.79 146 294892 9470 34652423
Serum ferritin increased 20.89 14.79 13 295025 6133 34655760
Spinal column injury 20.78 14.79 26 295012 598 34661295
Haematocrit decreased 20.70 14.79 173 294865 32043 34629850
Pneumatosis intestinalis 20.66 14.79 4 295034 3919 34657974
Psychomotor skills impaired 20.53 14.79 4 295034 3902 34657991
Crying 20.48 14.79 12 295026 5850 34656043
Bradykinesia 20.44 14.79 4 295034 3889 34658004
Acute graft versus host disease 20.43 14.79 15 295023 6488 34655405
Product dispensing error 20.33 14.79 14 295024 6260 34655633
Intraocular pressure increased 20.30 14.79 10 295028 5373 34656520
Cervical vertebral fracture 20.28 14.79 49 294989 1940 34659953
Neutrophilia 20.20 14.79 5 295033 4132 34657761
Impaired quality of life 20.20 14.79 12 295026 5806 34656087
Transplant failure 20.08 14.79 3 295035 3550 34658343
Pyelonephritis 19.97 14.79 14 295024 6201 34655692
Herpes simplex 19.97 14.79 11 295027 5548 34656345
Cardiac murmur 19.93 14.79 22 295016 7815 34654078
Food poisoning 19.92 14.79 47 294991 1832 34660061
Kidney infection 19.68 14.79 94 294944 5300 34656593
Portal vein thrombosis 19.66 14.79 4 295034 3784 34658109
Arteriosclerosis 19.63 14.79 45 294993 11923 34649970
Incorrect product administration duration 19.61 14.79 8 295030 4803 34657090
Immunoglobulins abnormal 19.59 14.79 7 295031 12 34661881
Occult blood positive 19.56 14.79 5 295033 4043 34657850
Primary amyloidosis 19.53 14.79 13 295025 125 34661768
Renal cyst 19.53 14.79 29 295009 9064 34652829
Hemiplegia 19.53 14.79 18 295020 6954 34654939
Disease complication 19.44 14.79 59 294979 2677 34659216
Normochromic normocytic anaemia 19.40 14.79 6 295032 4281 34657612
Duodenal ulcer haemorrhage 19.38 14.79 9 295029 5004 34656889
Hypoxic-ischaemic encephalopathy 19.36 14.79 7 295031 4525 34657368
Hypervolaemia 19.28 14.79 93 294945 19616 34642277
Superficial spreading melanoma stage I 19.24 14.79 7 295031 13 34661880
Bone loss 19.18 14.79 24 295014 552 34661341
Cardiac failure chronic 19.08 14.79 23 295015 7856 34654037
Vasculitis 18.91 14.79 42 294996 11254 34650639
Polyuria 18.75 14.79 27 295011 8547 34653346
Hepatitis fulminant 18.72 14.79 6 295032 4184 34657709
Hyperphosphataemia 18.71 14.79 7 295031 4430 34657463
Bladder transitional cell carcinoma stage 0 18.68 14.79 12 295026 108 34661785
Swollen tongue 18.67 14.79 62 294976 14543 34647350
H1N1 influenza 18.65 14.79 31 295007 931 34660962
Diverticulitis 18.58 14.79 254 294784 19750 34642143
Vitamin D deficiency 18.58 14.79 17 295021 6591 34655302
Hepatosplenomegaly 18.58 14.79 6 295032 4163 34657730
Mental status changes 18.41 14.79 219 294819 37864 34624029
Colon cancer metastatic 18.34 14.79 42 294996 1605 34660288
Lung consolidation 18.25 14.79 14 295024 5922 34655971
Large intestine polyp 18.23 14.79 24 295014 7890 34654003
Lung adenocarcinoma 18.22 14.79 83 294955 4588 34657305
Aplasia pure red cell 18.18 14.79 15 295023 6117 34655776
Abdominal distension 18.18 14.79 366 294672 58126 34603767
Haemorrhagic stroke 18.17 14.79 17 295021 6522 34655371
Gastric haemorrhage 18.14 14.79 37 295001 10224 34651669
Bundle branch block right 18.14 14.79 22 295016 7494 34654399
Ischaemia 18.06 14.79 8 295030 4572 34657321
Rebound effect 17.97 14.79 3 295035 3271 34658622
Hydrocephalus 17.87 14.79 11 295027 5221 34656672
Respiratory syncytial virus infection 17.87 14.79 83 294955 4626 34657267
Transformation to acute myeloid leukaemia 17.85 14.79 27 295011 747 34661146
Feeling jittery 17.81 14.79 74 294964 3929 34657964
Idiopathic pulmonary fibrosis 17.79 14.79 4 295034 3530 34658363
Spinal cord neoplasm 17.75 14.79 14 295024 179 34661714
Bladder transitional cell carcinoma 17.70 14.79 56 294982 2599 34659294
Gastrointestinal motility disorder 17.69 14.79 55 294983 2529 34659364
Psychiatric symptom 17.64 14.79 4 295034 3509 34658384
Blood immunoglobulin M increased 17.56 14.79 16 295022 252 34661641
Intentional dose omission 17.54 14.79 4 295034 3496 34658397
Therapeutic product effect decreased 17.49 14.79 198 294840 34545 34627348
Hip arthroplasty 17.38 14.79 8 295030 4471 34657422
Lymphadenopathy 17.33 14.79 155 294883 28308 34633585
Cyst 17.32 14.79 80 294958 4448 34657445
Systemic lupus erythematosus 17.24 14.79 5 295033 3719 34658174
Leukoencephalopathy 17.20 14.79 7 295031 4208 34657685
Tongue disorder 17.19 14.79 12 295026 5327 34656566
Gait inability 17.07 14.79 258 294780 20500 34641393
Stevens-Johnson syndrome 17.06 14.79 90 294948 18549 34643344
Scar 17.06 14.79 15 295023 5929 34655964
Exposure to toxic agent 16.89 14.79 5 295033 3670 34658223
Encephalitis 16.83 14.79 22 295016 7255 34654638
Mental impairment 16.78 14.79 39 294999 10283 34651610
Cardiac operation 16.72 14.79 3 295035 3104 34658789
Amnesia 16.67 14.79 316 294722 26247 34635646
Adenocarcinoma gastric 16.66 14.79 34 295004 1199 34660694
Anal abscess 16.65 14.79 18 295020 6455 34655438
Drug eruption 16.63 14.79 99 294939 19799 34642094
Procedural pain 16.56 14.79 10 295028 4796 34657097
Acute erythroid leukaemia 16.56 14.79 13 295025 165 34661728
Cardiotoxicity 16.52 14.79 14 295024 5634 34656259
Gastrooesophageal reflux disease 16.50 14.79 223 294815 37701 34624192
Major depression 16.49 14.79 9 295029 4563 34657330
Infusion site extravasation 16.49 14.79 8 295030 4336 34657557
Gastric ulcer 16.40 14.79 72 294966 15578 34646315
Papillary thyroid cancer 16.38 14.79 24 295014 645 34661248
Colorectal cancer 16.28 14.79 10 295028 4751 34657142
Neoplasm 16.27 14.79 90 294948 5377 34656516
Intestinal obstruction 16.27 14.79 277 294761 22545 34639348
Colorectal adenocarcinoma 16.20 14.79 14 295024 205 34661688
Hypoalbuminaemia 16.03 14.79 51 294987 12123 34649770
Ventricular extrasystoles 16.03 14.79 50 294988 11958 34649935
Lymphopenia 16.02 14.79 77 294961 16258 34645635
Blood uric acid increased 15.94 14.79 36 295002 9588 34652305
Laboratory test 15.89 14.79 6 295032 13 34661880
Mucormycosis 15.87 14.79 16 295022 5926 34655967
Frequent bowel movements 15.85 14.79 55 294983 12732 34649161
Venous thrombosis limb 15.74 14.79 45 294993 1974 34659919
Granuloma 15.74 14.79 4 295034 3247 34658646
Neurological decompensation 15.67 14.79 3 295035 2963 34658930
Furuncle 15.67 14.79 63 294975 3295 34658598
Alcoholism 15.66 14.79 3 295035 2962 34658931
Aortic valve incompetence 15.66 14.79 16 295022 5888 34656005
Movement disorder 15.65 14.79 52 294986 12196 34649697
Tumour haemorrhage 15.64 14.79 3 295035 2959 34658934
Diplopia 15.60 14.79 81 294957 16762 34645131
Enteritis 15.58 14.79 28 295010 8114 34653779
Muscle haemorrhage 15.46 14.79 6 295032 3712 34658181
Syncope 15.41 14.79 623 294415 90828 34571065
Haemolysis 15.34 14.79 28 295010 8066 34653827
Ecchymosis 15.30 14.79 21 295017 6782 34655111
Sudden death 15.29 14.79 71 294967 15130 34646763
Liver function test increased 15.27 14.79 67 294971 14498 34647395
Transitional cell cancer of the renal pelvis and ureter 15.26 14.79 7 295031 29 34661864
Cold sweat 15.24 14.79 39 294999 9948 34651945
Irritability 15.23 14.79 134 294904 24556 34637337
Pulmonary alveolar haemorrhage 15.14 14.79 25 295013 7487 34654406
Vertigo 15.13 14.79 140 294898 25396 34636497
Hepatic amyloidosis 15.13 14.79 4 295034 0 34661893
Hyperuricaemia 15.09 14.79 28 295010 8015 34653878
Anal fistula 15.05 14.79 14 295024 5385 34656508
Plasma cell myeloma in remission 15.04 14.79 6 295032 16 34661877
Psychomotor retardation 14.99 14.79 6 295032 3644 34658249
Hyperaesthesia teeth 14.99 14.79 21 295017 541 34661352
Cerebral atrophy 14.96 14.79 10 295028 4542 34657351
Disability 14.96 14.79 11 295027 4754 34657139
Iron deficiency 14.94 14.79 14 295024 5367 34656526
Venoocclusive disease 14.94 14.79 3 295035 2864 34659029
Injection site induration 14.88 14.79 3 295035 2857 34659036
Depressive symptom 14.88 14.79 3 295035 2856 34659037
Eyelid ptosis 14.87 14.79 16 295022 5750 34656143
Blood calcium abnormal 14.82 14.79 21 295017 547 34661346
Blood sodium increased 14.80 14.79 3 295035 2845 34659048

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Death 7679.70 13.29 10963 347824 555551 78830050
Full blood count decreased 6891.74 13.29 3037 355750 23782 79361819
Pneumonia 5138.08 13.29 9967 348820 650279 78735322
White blood cell count decreased 4824.95 13.29 5043 353744 183245 79202356
Thrombosis 4613.50 13.29 3471 355316 80629 79304972
Neuropathy peripheral 4368.05 13.29 4192 354595 137113 79248488
Diarrhoea 4267.84 13.29 11002 347785 869487 78516114
Platelet count decreased 3998.65 13.29 4644 354143 190020 79195581
Rash 3079.50 13.29 7504 351283 570854 78814747
Deep vein thrombosis 2107.10 13.29 2657 356130 118262 79267339
Fatigue 2084.36 13.29 8965 349822 920762 78464839
Neutropenia 1843.70 13.29 4023 354764 283687 79101914
Unevaluable event 1655.72 13.29 1618 357169 53967 79331634
Constipation 1472.59 13.29 3648 355139 279402 79106199
Laboratory test abnormal 1459.39 13.29 1123 357664 26925 79358676
Muscle spasms 1402.92 13.29 2684 356103 172046 79213555
Drug interaction 1353.99 13.29 146 358641 415037 78970564
Plasma cell myeloma 1321.58 13.29 1405 357382 51854 79333747
Plasma cell myeloma recurrent 1275.84 13.29 564 358223 4437 79381164
COVID-19 1168.25 13.29 2342 356445 155332 79230269
Neutrophil count decreased 1157 13.29 1747 357040 92212 79293389
Thrombocytopenia 1094.36 13.29 3138 355649 262121 79123480
Condition aggravated 1069.59 13.29 459 358328 500665 78884936
Pancytopenia 1060.04 13.29 2318 356469 163427 79222174
Product dose omission issue 1054.79 13.29 2963 355824 244574 79141027
Completed suicide 941.26 13.29 38 358749 245729 79139872
Pulmonary embolism 907.78 13.29 2228 356559 169426 79216175
Drug ineffective 893.31 13.29 2244 356543 1078669 78306932
Human chorionic gonadotropin increased 886.60 13.29 293 358494 891 79384710
Rheumatoid arthritis 812.79 13.29 28 358759 208442 79177159
Pulmonary thrombosis 776.24 13.29 551 358236 11620 79373981
Haemoglobin decreased 751.09 13.29 2452 356335 219667 79165934
Red blood cell count decreased 729.98 13.29 1085 357702 56428 79329173
Drug abuse 693.17 13.29 7 358780 162684 79222917
Plasmacytoma 675.07 13.29 350 358437 4053 79381548
Contraindicated product administered 648.53 13.29 12 358775 157526 79228075
Rash pruritic 642.55 13.29 1155 357632 70474 79315127
Cytopenia 619.06 13.29 600 358187 19783 79365818
Synovitis 584.81 13.29 21 358766 150713 79234888
Squamous cell carcinoma of skin 583.61 13.29 493 358294 13540 79372061
Drug hypersensitivity 577.06 13.29 313 358474 298603 79086998
Blood potassium decreased 552.62 13.29 851 357936 45661 79339940
Overdose 550.98 13.29 85 358702 184121 79201480
Asthenia 543.57 13.29 4049 354738 507640 78877961
Maternal exposure during pregnancy 526.31 13.29 20 358767 136518 79249083
Dehydration 521.12 13.29 2355 356432 245832 79139769
Anaemia 517.25 13.29 3599 355188 441416 78944185
Myelodysplastic syndrome 512.91 13.29 657 358130 29644 79355957
Ageusia 502.11 13.29 488 358299 16144 79369457
Injection site pain 497.12 13.29 20 358767 129818 79255783
Systemic lupus erythematosus 491.54 13.29 11 358776 121138 79264463
Headache 489.86 13.29 1421 357366 652351 78733250
Acute myeloid leukaemia 475.25 13.29 639 358148 30246 79355355
Arthralgia 464.78 13.29 1194 357593 570609 78814992
Product use in unapproved indication 459.05 13.29 279 358508 250080 79135521
Cardiac disorder 439.62 13.29 937 357850 64820 79320781
Hip fracture 432.05 13.29 609 358178 30152 79355449
Pemphigus 420.84 13.29 5 358782 99577 79286024
Sepsis 405.78 13.29 2329 356458 267099 79118502
Adverse drug reaction 399.60 13.29 907 357880 65485 79320116
Renal failure 390.69 13.29 1865 356922 199103 79186498
Influenza 373.13 13.29 1357 357430 128249 79257352
Therapeutic product effect decreased 368.51 13.29 138 358649 163725 79221876
Light chain analysis increased 366.29 13.29 171 358616 1547 79384054
Treatment failure 363.11 13.29 156 358631 170330 79215271
Acute lymphocytic leukaemia 359.21 13.29 243 358544 4726 79380875
Exposure during pregnancy 354.85 13.29 26 358761 101106 79284495
Plasma cell leukaemia 353.85 13.29 169 358618 1617 79383984
Fall 350.60 13.29 3541 355246 484088 78901513
Tooth disorder 344.42 13.29 503 358284 25730 79359871
Atrial fibrillation 341.80 13.29 1776 357011 196110 79189491
Renal disorder 334.97 13.29 645 358142 41460 79344141
Product use issue 326.79 13.29 278 358509 209544 79176057
Peripheral swelling 324.11 13.29 2200 356587 267417 79118184
Disease progression 321.41 13.29 1659 357128 182703 79202898
Pain 318.24 13.29 1862 356925 701940 78683661
Intentional product misuse 308.26 13.29 34 358753 95131 79290470
Hypertension 308.02 13.29 642 358145 330350 79055251
Discomfort 304.67 13.29 93 358694 125524 79260077
Mobility decreased 304.46 13.29 86 358701 122089 79263512
Blood pressure increased 301.99 13.29 303 358484 211057 79174544
Suicide attempt 300.74 13.29 18 358769 82914 79302687
Glossodynia 290.64 13.29 56 358731 103281 79282320
Tachycardia 278.66 13.29 234 358553 177534 79208067
Alanine aminotransferase increased 277.73 13.29 196 358591 162374 79223227
Urinary tract infection 275.84 13.29 2146 356641 272366 79113235
Aspartate aminotransferase increased 274.92 13.29 140 358647 138501 79247100
Infusion related reaction 274.40 13.29 381 358406 229856 79155745
Inappropriate schedule of product administration 273.98 13.29 129 358658 133499 79252102
Pericarditis 267.97 13.29 69 358718 104167 79281434
Coma 267.77 13.29 62 358725 100587 79285014
Monoclonal immunoglobulin present 265.94 13.29 119 358668 966 79384635
Dry skin 262.88 13.29 787 358000 67208 79318393
Cerebrovascular accident 262.72 13.29 1386 357401 153906 79231695
Pruritus 258.87 13.29 2814 355973 391834 78993767
Blood cholesterol increased 253.98 13.29 37 358750 83683 79301918
Psoriasis 253.11 13.29 48 358739 89539 79296062
Alopecia 252.29 13.29 407 358380 230948 79154653
Depressed level of consciousness 250.34 13.29 63 358724 96589 79289012
Abdominal pain 249.88 13.29 906 357881 388663 78996938
Rhabdomyolysis 248.92 13.29 77 358710 103054 79282547
Wrong technique in product usage process 248.09 13.29 23 358764 73852 79311749
Adverse event 246.21 13.29 711 358076 59503 79326098
Fibromyalgia 245.93 13.29 10 358777 64330 79321271
Helicobacter infection 244.30 13.29 18 358769 69686 79315915
Taste disorder 242.82 13.29 327 358460 15496 79370105
Therapeutic product effect incomplete 239.01 13.29 173 358614 141472 79244129
Injection site erythema 236.19 13.29 35 358752 78162 79307439
Spinal fracture 235.29 13.29 345 358442 17709 79367892
Hyponatraemia 235.07 13.29 272 358515 177576 79208025
Herpes zoster 234.32 13.29 934 357853 92149 79293452
Rheumatoid factor positive 233.20 13.29 8 358779 59831 79325770
Wheezing 231.01 13.29 118 358669 116546 79269055
Oxygen saturation decreased 229.21 13.29 149 358638 128898 79256703
Skin discolouration 228.67 13.29 544 358243 40490 79345111
Anxiety 222.77 13.29 492 358295 248020 79137581
Full blood count abnormal 221.69 13.29 533 358254 39941 79345660
Wound 216.25 13.29 127 358660 116052 79269549
Medication error 216.15 13.29 27 358760 68615 79316986
Musculoskeletal stiffness 210.08 13.29 288 358499 174720 79210881
Adenocarcinoma of colon 208.76 13.29 184 358603 5357 79380244
Hypoglycaemia 208.36 13.29 98 358689 101496 79284105
Blood pressure systolic increased 206.96 13.29 28 358759 66958 79318643
Tumour flare 203.59 13.29 100 358687 1023 79384578
Cataract 201.65 13.29 677 358110 61443 79324158
Blood creatine phosphokinase increased 198.64 13.29 30 358757 66060 79319541
Bronchitis 196.77 13.29 1130 357657 129514 79256087
COVID-19 pneumonia 194.95 13.29 413 358374 28436 79357165
Basal cell carcinoma 194.92 13.29 483 358304 36892 79348709
Sedation 192.05 13.29 10 358777 51885 79333716
Suicidal ideation 191.54 13.29 53 358734 76287 79309314
Hepatic enzyme increased 190.01 13.29 331 358456 182279 79203322
B precursor type acute leukaemia 187.06 13.29 71 358716 357 79385244
Bradycardia 183.81 13.29 203 358584 135354 79250247
SARS-CoV-2 test positive 182.65 13.29 244 358543 11472 79374129
Muscle injury 180.84 13.29 9 358778 48552 79337049
Folliculitis 178.79 13.29 20 358767 55360 79330241
Agitation 177.25 13.29 115 358672 99600 79286001
Anaphylactic reaction 176.06 13.29 78 358709 83665 79301936
Loss of personal independence in daily activities 176.04 13.29 123 358664 102457 79283144
Injection site swelling 174.68 13.29 9 358778 47123 79338478
Red blood cell sedimentation rate increased 172.74 13.29 8 358779 45934 79339667
Plasma cell myeloma refractory 172.08 13.29 76 358711 596 79385005
Metabolic acidosis 171.73 13.29 78 358709 82451 79303150
Knee arthroplasty 171.33 13.29 5 358782 43243 79342358
C-reactive protein increased 169.74 13.29 198 358589 128829 79256772
Migraine 169.50 13.29 91 358696 87402 79298199
Protein total increased 167.98 13.29 138 358649 3641 79381960
Weight increased 166.76 13.29 662 358125 276724 79108877
Injury 163.20 13.29 72 358715 77424 79308177
Osteoarthritis 161.68 13.29 96 358691 87213 79298388
Inflammation 161.43 13.29 112 358675 93641 79291960
Hyperkalaemia 161.03 13.29 166 358621 114232 79271369
Blood pressure fluctuation 160.46 13.29 51 358736 67094 79318507
Impaired healing 160.05 13.29 98 358689 87557 79298044
Lactic acidosis 158.53 13.29 59 358728 70300 79315301
Incorrect dose administered 157.00 13.29 74 358713 76556 79309045
Hypoaesthesia 156.75 13.29 1359 357428 177993 79207608
Stress 155.40 13.29 82 358705 79530 79306071
Injection site bruising 154.62 13.29 7 358780 40995 79344606
Gout 154.32 13.29 343 358444 24406 79361195
Injection site reaction 153.37 13.29 30 358757 54755 79330846
Depression 153.26 13.29 483 358304 216307 79169294
Infection 151.55 13.29 1709 357078 240003 79145598
Injection site pruritus 147.93 13.29 11 358776 42272 79343329
Electrocardiogram QT prolonged 147.80 13.29 114 358673 90272 79295329
Vomiting 147.62 13.29 2109 356678 663719 78721882
Drug level increased 145.60 13.29 8 358779 39643 79345958
Type 2 diabetes mellitus 142.66 13.29 40 358747 57082 79328519
Hiccups 141.43 13.29 199 358588 9832 79375769
Drug withdrawal syndrome 141.38 13.29 3 358784 34715 79350886
Full blood count increased 135.40 13.29 61 358726 504 79385097
Respiratory arrest 135.25 13.29 45 358742 57505 79328096
Drug-induced liver injury 135.22 13.29 64 358723 66053 79319548
Somnolence 135.10 13.29 584 358203 238397 79147204
Acute leukaemia 133.41 13.29 88 358699 1638 79383963
Asthma 133.25 13.29 253 358534 134842 79250759
Cardiac failure congestive 132.32 13.29 1094 357693 141308 79244293
Back disorder 130.73 13.29 207 358580 11371 79374230
Bone pain 129.70 13.29 546 358241 55196 79330405
Drug ineffective for unapproved indication 129.61 13.29 35 358752 51203 79334398
Hip arthroplasty 128.90 13.29 8 358779 35748 79349853
Decreased appetite 127.19 13.29 2206 356581 340212 79045389
Pallor 127.00 13.29 34 358753 50028 79335573
General physical health deterioration 126.66 13.29 723 358064 274515 79111086
Ascites 126.50 13.29 93 358694 75469 79310132
Gallbladder disorder 126.21 13.29 273 358514 19067 79366534
Pathological fracture 125.39 13.29 193 358594 10344 79375257
Renal impairment 125.27 13.29 1171 357616 156612 79228989
Emotional distress 125.16 13.29 16 358771 39953 79345648
Prescribed overdose 124.02 13.29 13 358774 37870 79347731
Product prescribing error 122.41 13.29 26 358761 44787 79340814
Dysgeusia 121.52 13.29 545 358242 56632 79328969
Obesity 120.46 13.29 10 358777 35115 79350486
Blood test abnormal 120.19 13.29 254 358533 17456 79368145
Liver injury 118.57 13.29 53 358734 56561 79329040
Gamma-glutamyltransferase increased 118.01 13.29 49 358738 54631 79330970
Aggression 117.75 13.29 41 358746 50917 79334684
Interstitial lung disease 117.18 13.29 204 358583 112396 79273205
Hordeolum 117.11 13.29 105 358682 3128 79382473
Irritable bowel syndrome 115.85 13.29 68 358719 62173 79323428
Joint range of motion decreased 115.47 13.29 9 358778 33273 79352328
Ill-defined disorder 114.33 13.29 78 358709 65797 79319804
Incorrect route of product administration 114.32 13.29 12 358775 34917 79350684
Erythema 113.57 13.29 567 358220 222723 79162878
Palpitations 113.08 13.29 251 358536 126359 79259242
Underdose 112.16 13.29 10 358777 33141 79352460
Spinal compression fracture 111.37 13.29 240 358547 16718 79368883
Malignant melanoma 111.36 13.29 221 358566 14520 79371081
Rib fracture 111.33 13.29 327 358460 27620 79357981
Dysarthria 110.92 13.29 85 358702 67537 79318064
Upper limb fracture 110.88 13.29 248 358539 17719 79367882
Malignant neoplasm of unknown primary site 109.62 13.29 58 358729 702 79384899
Osteolysis 108.54 13.29 117 358670 4381 79381220
Hypercalcaemia 108.47 13.29 400 358387 38030 79347571
Bone lesion 107.55 13.29 133 358654 5786 79379815
Cardio-respiratory arrest 107.18 13.29 203 358584 108307 79277294
Seizure 106.36 13.29 462 358325 188372 79197229
Product quality issue 102.92 13.29 15 358772 33925 79351676
Clostridium difficile infection 102.34 13.29 422 358365 42263 79343338
Musculoskeletal pain 101.52 13.29 191 358596 102163 79283438
Hypersensitivity 100.15 13.29 729 358058 261510 79124091
Anaphylactic shock 100.15 13.29 20 358767 35976 79349625
Obstructive airways disorder 99.95 13.29 12 358775 31447 79354154
Leukaemia 99.50 13.29 128 358659 5797 79379804
International normalised ratio increased 99.04 13.29 142 358645 84579 79301022
Cardiac amyloidosis 98.57 13.29 75 358712 1765 79383836
Blood alkaline phosphatase increased 98.23 13.29 85 358702 63579 79322022
Hallucination, visual 98.02 13.29 15 358772 32714 79352887
Swelling face 97.56 13.29 601 358186 70611 79314990
Myoclonus 97.32 13.29 7 358780 27653 79357948
Flushing 96.39 13.29 155 358632 88113 79297488
Generalised tonic-clonic seizure 95.32 13.29 39 358748 43871 79341730
Pregnancy test false positive 94.55 13.29 32 358755 107 79385494
Respiratory depression 94.39 13.29 8 358779 27622 79357979
Abortion spontaneous 94.38 13.29 11 358776 29496 79356105
Withdrawal syndrome 93.90 13.29 7 358780 26847 79358754
Abnormal behaviour 93.79 13.29 24 358763 36397 79349204
Colitis ulcerative 93.18 13.29 21 358766 34721 79350880
Injection site haemorrhage 92.70 13.29 9 358778 27861 79357740
Blood pressure diastolic decreased 92.45 13.29 13 358774 30203 79355398
Surgery 91.59 13.29 18 358769 32748 79352853
Cellulitis 90.37 13.29 817 357970 108243 79277358
Depressed mood 90.18 13.29 53 358734 48427 79337174
Osteonecrosis of jaw 89.59 13.29 409 358378 42817 79342784
Back pain 89.39 13.29 1891 356896 302289 79083312
Body temperature decreased 89.14 13.29 18 358769 32127 79353474
Dyskinesia 89.03 13.29 45 358742 44728 79340873
B-cell type acute leukaemia 88.55 13.29 45 358742 498 79385103
Extrapyramidal disorder 88.47 13.29 3 358784 22676 79362925
Chest discomfort 88.34 13.29 321 358466 137723 79247878
Angioedema 88.33 13.29 128 358659 75907 79309694
Melaena 87.21 13.29 87 358700 60803 79324798
Hypercholesterolaemia 86.89 13.29 4 358783 23091 79362510
Product distribution issue 86.88 13.29 62 358725 1318 79384283
Arthritis 86.12 13.29 249 358538 114631 79270970
Dementia 85.61 13.29 275 358512 24384 79361217
Hepatitis 85.26 13.29 75 358712 55652 79329949
Hepatotoxicity 83.65 13.29 65 358722 51287 79334314
Gait disturbance 83.54 13.29 568 358219 206938 79178663
Pneumonia influenzal 83.53 13.29 83 358704 2821 79382780
Compression fracture 83.52 13.29 123 358664 6337 79379264
Monoclonal immunoglobulin increased 83.36 13.29 30 358757 126 79385475
Hepatocellular injury 83.06 13.29 56 358731 47537 79338064
Device dislocation 82.28 13.29 10 358777 25960 79359641
Blister 81.73 13.29 270 358517 119206 79266395
Diabetic ketoacidosis 79.62 13.29 27 358760 34095 79351506
Blood magnesium decreased 79.43 13.29 207 358580 16305 79369296
Arthropathy 78.87 13.29 470 358317 176641 79208960
Upper respiratory tract infection 78.63 13.29 689 358098 90479 79295122
Amyloidosis 77.20 13.29 77 358710 2629 79382972
Localised infection 76.73 13.29 354 358433 37221 79348380
Coronavirus infection 76.45 13.29 128 358659 7369 79378232
Hepatic steatosis 76.44 13.29 37 358750 37701 79347900
Transaminases increased 76.35 13.29 72 358715 51671 79333930
Muscle rigidity 76.28 13.29 3 358784 19879 79365722
Heart rate increased 75.75 13.29 283 358504 120441 79265160
Unresponsive to stimuli 75.09 13.29 84 358703 55704 79329897
Osteoporosis 74.46 13.29 80 358707 54032 79331569
Myelodysplastic syndrome transformation 73.18 13.29 43 358744 646 79384955
Neutrophil count increased 72.63 13.29 21 358766 29375 79356226
Pregnancy 72.48 13.29 16 358771 26835 79358766
Psychotic disorder 71.87 13.29 49 358738 41353 79344248
Joint swelling 71.84 13.29 892 357895 287754 79097847
Immune system disorder 71.18 13.29 155 358632 10874 79374727
Fear 70.81 13.29 8 358779 21978 79363623
White blood cell count increased 70.77 13.29 143 358644 74490 79311111
Pyrexia 70.76 13.29 3731 355056 674978 78710623
Spinal disorder 70.61 13.29 148 358639 10112 79375489
Sleep disorder 70.00 13.29 178 358609 85499 79300102
Respiratory syncytial virus infection 69.87 13.29 140 358647 9262 79376339
Diverticulitis 69.54 13.29 398 358389 45538 79340063
Accidental exposure to product 69.33 13.29 27 358760 31295 79354306
Fracture 69.32 13.29 236 358551 21565 79364036
Malignant melanoma in situ 68.53 13.29 69 358718 2383 79383218
Dystonia 68.39 13.29 8 358779 21391 79364210
Product administration error 67.97 13.29 29 358758 31817 79353784
Bone erosion 67.44 13.29 3 358784 17844 79367757
Multiple sclerosis 67.21 13.29 10 358777 22272 79363329
Gastrooesophageal reflux disease 66.96 13.29 242 358545 104004 79281597
Impaired work ability 66.41 13.29 6 358781 19675 79365926
Procedural pain 65.97 13.29 12 358775 23072 79362529
Live birth 65.22 13.29 5 358782 18739 79366862
Clostridium difficile colitis 65.08 13.29 303 358484 31980 79353621
Respiratory tract infection 64.85 13.29 408 358379 48281 79337320
Refractory cytopenia with multilineage dysplasia 64.12 13.29 29 358758 242 79385359
Blood urea increased 64 13.29 75 358712 48715 79336886
Rectal adenocarcinoma 63.82 13.29 53 358734 1420 79384181
Ventricular fibrillation 63.61 13.29 32 358755 31894 79353707
Toxic epidermal necrolysis 63.50 13.29 64 358723 44517 79341084
Cardiogenic shock 63.41 13.29 57 358730 41857 79343744
Intentional product use issue 63.38 13.29 999 357788 151113 79234488
Grip strength decreased 63.30 13.29 11 358776 21858 79363743
Delirium 63 13.29 184 358603 84443 79301158
Sputum discoloured 62.80 13.29 11 358776 21732 79363869
Blood bilirubin increased 62.72 13.29 127 358660 66105 79319496
Refractory anaemia with an excess of blasts 62.39 13.29 43 358744 863 79384738
Hyperviscosity syndrome 62.33 13.29 33 358754 400 79385201
Sinus tachycardia 62.32 13.29 45 358742 36863 79348738
Sleep apnoea syndrome 62.22 13.29 44 358743 36434 79349167
Pulmonary fibrosis 62.06 13.29 64 358723 44048 79341553
Pulmonary arterial hypertension 61.88 13.29 25 358762 28341 79357260
Haematemesis 61.67 13.29 87 358700 52177 79333424
Device malfunction 61.62 13.29 11 358776 21437 79364164
Tumour lysis syndrome 60.83 13.29 241 358546 23698 79361903
Hypogeusia 60.55 13.29 56 358731 1738 79383863
Intraductal proliferative breast lesion 60.47 13.29 65 358722 2426 79383175
Rash macular 60.30 13.29 274 358513 28625 79356976
Cholestasis 60.25 13.29 88 358699 52021 79333580
Lower respiratory tract infection 60.15 13.29 338 358449 128882 79256719
Metastases to bone 59.35 13.29 18 358769 24409 79361192
Hemiparesis 58.45 13.29 40 358747 33693 79351908
Tachypnoea 58.30 13.29 36 358751 32027 79353574
Skin exfoliation 57.55 13.29 435 358352 54665 79330936
Delusion 57.55 13.29 11 358776 20412 79365189
Torsade de pointes 57.49 13.29 9 358778 19303 79366298
Drug resistance 57.43 13.29 63 358724 42150 79343451
Hallucination 57.11 13.29 196 358591 85549 79300052
Metastases to liver 56.98 13.29 28 358759 28286 79357315
Therapy partial responder 56.79 13.29 190 358597 17207 79368394
Liver function test abnormal 56.59 13.29 129 358658 64346 79321255
Bone marrow failure 56.53 13.29 409 358378 50698 79334903
Pemphigoid 56.51 13.29 3 358784 15312 79370289
Hypokinesia 56.48 13.29 9 358778 19051 79366550
Oedema peripheral 56.24 13.29 1510 357277 250778 79134823
Autoimmune disorder 56.23 13.29 5 358782 16607 79368994
Illness 56.00 13.29 380 358407 46131 79339470
Lung adenocarcinoma 55.95 13.29 115 358672 7749 79377852
Therapeutic response shortened 55.85 13.29 4 358783 15859 79369742
Transplant rejection 55.78 13.29 10 358777 19427 79366174
Disability 55.72 13.29 6 358781 17114 79368487
Confusional state 55.45 13.29 1052 357735 316945 79068656
Lactose intolerance 55.16 13.29 60 358727 2270 79383331
Glycosylated haemoglobin increased 55.07 13.29 10 358777 19250 79366351
Accidental overdose 55.04 13.29 58 358729 39523 79346078
Upper gastrointestinal haemorrhage 54.93 13.29 63 358724 41317 79344284
Status epilepticus 54.74 13.29 22 358765 25019 79360582
Myositis 54.70 13.29 10 358777 19158 79366443
Leukocytosis 54.67 13.29 69 358718 43386 79342215
Blood electrolytes decreased 54.64 13.29 48 358739 1391 79384210
Tenosynovitis 54.54 13.29 4 358783 15550 79370051
Multiple allergies 54.34 13.29 135 358652 10325 79375276
Injection site warmth 54.32 13.29 3 358784 14804 79370797
Transformation to acute myeloid leukaemia 54.21 13.29 41 358746 956 79384645
Crying 54.17 13.29 18 358769 23025 79362576
Schizophrenia 54.06 13.29 4 358783 15436 79370165
Rales 53.82 13.29 12 358775 19989 79365612
Cyanosis 53.64 13.29 23 358764 25159 79360442
Skin cancer 53.37 13.29 169 358618 14871 79370730
Hepatic encephalopathy 53.21 13.29 21 358766 24145 79361456
Haematuria 53.20 13.29 147 358640 68689 79316912
Hypothermia 53.07 13.29 18 358769 22728 79362873
Atrial flutter 52.79 13.29 215 358572 21410 79364191
Viral infection 52.72 13.29 353 358434 42663 79342938
Pelvic fracture 52.68 13.29 147 358640 12057 79373544
Pancreatitis acute 52.38 13.29 89 358698 49515 79336086
Transient ischaemic attack 52.25 13.29 411 358376 52284 79333317
Myocardial infarction 52.19 13.29 1139 357648 182990 79202611
Coagulopathy 52.07 13.29 51 358736 35955 79349646
Uveitis 52.06 13.29 7 358780 16823 79368778
Blood triglycerides increased 52.04 13.29 15 358772 21025 79364576
Anhedonia 51.76 13.29 4 358783 14894 79370707
Therapeutic response unexpected 51.63 13.29 13 358774 19933 79365668
Foot deformity 51.26 13.29 22 358765 24052 79361549
Parkinsonism 51.06 13.29 7 358780 16577 79369024
Breath sounds abnormal 51.02 13.29 6 358781 15978 79369623
Light chain analysis abnormal 50.85 13.29 23 358764 192 79385409
Poor venous access 50.66 13.29 10 358777 18139 79367462
Nasopharyngitis 50.58 13.29 1498 357289 252383 79133218
Skin necrosis 50.42 13.29 10 358777 18077 79367524
Hepatic failure 50.13 13.29 127 358660 61085 79324516
Tubulointerstitial nephritis 49.91 13.29 59 358728 38176 79347425
Shock 49.90 13.29 74 358713 43474 79342127
Hepatic cirrhosis 49.84 13.29 50 358737 34856 79350745
Encephalopathy 49.83 13.29 147 358640 67250 79318351
Proteinuria 49.40 13.29 44 358743 32458 79353143
Speech disorder 49.36 13.29 107 358680 54338 79331263
Ventricular tachycardia 49.29 13.29 70 358717 41865 79343736
Seasonal allergy 49.03 13.29 174 358613 16232 79369369
Invasive ductal breast carcinoma 48.99 13.29 92 358695 5800 79379801
Respiratory rate increased 48.84 13.29 18 358769 21582 79364019
Mucosal inflammation 48.84 13.29 175 358612 75405 79310196
Infusion site pain 48.71 13.29 4 358783 14172 79371429
Dyspnoea exertional 48.40 13.29 214 358573 86859 79298742
Hypothyroidism 48.30 13.29 102 358685 52290 79333311
Circulatory collapse 48.24 13.29 59 358728 37609 79347992
Epilepsy 48.23 13.29 68 358719 40792 79344809
Body height decreased 48.06 13.29 114 358673 8466 79377135
Hyperlipidaemia 47.86 13.29 29 358758 26064 79359537
Iron deficiency anaemia 47.84 13.29 28 358759 25644 79359957
Visceral leishmaniasis 47.81 13.29 40 358747 1083 79384518
Gastric disorder 47.58 13.29 310 358477 37123 79348478
Pulmonary hypertension 47.42 13.29 90 358697 47990 79337611
Joint stiffness 47.16 13.29 69 358718 40761 79344840
White blood cell count abnormal 46.89 13.29 89 358698 5656 79379945
Acute hepatic failure 46.70 13.29 40 358747 30073 79355528
Jaundice 46.61 13.29 107 358680 53242 79332359
Eczema 46.15 13.29 70 358717 40748 79344853
Right ventricular failure 46.14 13.29 24 358763 23473 79362128
Paranoia 45.99 13.29 15 358772 19417 79366184
Colon cancer 45.98 13.29 157 358630 14366 79371235
Neurotoxicity 45.95 13.29 47 358740 32471 79353130
Motor dysfunction 45.88 13.29 6 358781 14727 79370874
Restlessness 45.88 13.29 87 358700 46405 79339196
Post procedural complication 45.82 13.29 25 358762 23804 79361797
Chondrocalcinosis pyrophosphate 45.61 13.29 48 358739 1748 79383853
Hypoxia 45.40 13.29 275 358512 102968 79282633
Squamous cell carcinoma 45.25 13.29 164 358623 15458 79370143
Disturbance in attention 45.10 13.29 101 358686 50700 79334901
Altered state of consciousness 45.02 13.29 80 358707 43742 79341859
Acute kidney injury 44.55 13.29 1897 356890 517507 78868094
Tremor 44.10 13.29 1039 357748 169044 79216557
Adenocarcinoma pancreas 44.08 13.29 50 358737 1983 79383618
Eye swelling 43.84 13.29 235 358552 26233 79359368
Blood calcium increased 43.65 13.29 124 358663 10276 79375325
Coordination abnormal 43.45 13.29 12 358775 17300 79368301
Productive cough 43.33 13.29 227 358560 88104 79297497
Transfusion 43.07 13.29 21 358766 21309 79364292
Injection site urticaria 43.04 13.29 4 358783 12822 79372779
Panic attack 42.92 13.29 28 358759 24188 79361413
Middle insomnia 42.52 13.29 10 358777 16059 79369542
Blood loss anaemia 42.31 13.29 9 358778 15489 79370112
Myalgia 42.00 13.29 585 358202 185056 79200545
Anuria 41.78 13.29 21 358766 20942 79364659
Diabetes mellitus inadequate control 41.74 13.29 29 358758 24235 79361366
Abdominal discomfort 41.70 13.29 836 357951 249891 79135710
Prostatic disorder 41.62 13.29 50 358737 2110 79383491
Spinal cord compression 41.59 13.29 90 358697 6287 79379314
Eye infection 41.43 13.29 133 358654 11787 79373814
Red cell distribution width increased 41.31 13.29 9 358778 15233 79370368
Product storage error 41.19 13.29 11 358776 16215 79369386
Panniculitis 41.13 13.29 4 358783 12367 79373234
Platelet disorder 41.13 13.29 58 358729 2871 79382730
Adenocarcinoma gastric 41.09 13.29 45 358742 1716 79383885
Bladder transitional cell carcinoma 41.01 13.29 55 358732 2595 79383006
Swelling 40.87 13.29 707 358080 216004 79169597
Blood immunoglobulin G increased 40.22 13.29 58 358729 2931 79382670
Failure to thrive 40.13 13.29 131 358656 11713 79373888
Arteriosclerosis coronary artery 40.03 13.29 15 358772 17801 79367800
Metastases to lung 39.63 13.29 16 358771 18147 79367454
Concomitant disease aggravated 39.51 13.29 6 358781 13161 79372440
Electrocardiogram abnormal 39.47 13.29 13 358774 16724 79368877
Tendonitis 39.02 13.29 30 358757 23800 79361801
Injection site rash 38.88 13.29 16 358771 17938 79367663
Agranulocytosis 38.78 13.29 91 358696 44939 79340662
White blood cell disorder 38.73 13.29 59 358728 3133 79382468
Hypomagnesaemia 38.67 13.29 97 358690 46814 79338787
Bursitis 38.13 13.29 64 358723 35780 79349821
Primary amyloidosis 37.99 13.29 17 358770 138 79385463
Enthesopathy 37.95 13.29 4 358783 11604 79373997
Hallucination, auditory 37.95 13.29 23 358764 20670 79364931
Cervical vertebral fracture 37.77 13.29 63 358724 3615 79381986
Haematoma 37.75 13.29 115 358672 52080 79333521
Septic shock 37.49 13.29 768 358019 122033 79263568
Brain oedema 37.45 13.29 35 358752 25228 79360373
Ovarian cyst 37.44 13.29 6 358781 12649 79372952
Basosquamous carcinoma of skin 37.20 13.29 10 358777 10 79385591
Malignant neoplasm progression 37.19 13.29 837 357950 135153 79250448
Aplastic anaemia 37.12 13.29 17 358770 17888 79367713
Coeliac disease 36.89 13.29 4 358783 11347 79374254
Blood calcium abnormal 36.85 13.29 38 358749 1351 79384250
Haemodynamic instability 36.82 13.29 16 358771 17366 79368235
Chronic sinusitis 36.74 13.29 7 358780 13019 79372582
Hepatic function abnormal 36.35 13.29 187 358600 72920 79312681
Paraesthesia 36.08 13.29 1044 357743 175279 79210322
Lymphocytic leukaemia 35.98 13.29 19 358768 229 79385372
Drug intolerance 35.86 13.29 909 357878 263210 79122391
Bronchiectasis 35.62 13.29 29 358758 22357 79363244
Metastases to lymph nodes 35.54 13.29 3 358784 10394 79375207
Mitral valve incompetence 35.27 13.29 46 358741 28519 79357082
Hernia 35.04 13.29 161 358626 16898 79368703
Colon cancer metastatic 34.88 13.29 46 358741 2135 79383466
Heart rate decreased 34.88 13.29 180 358607 70136 79315465
Lentigo maligna 34.81 13.29 25 358762 537 79385064
Pneumonia pneumococcal 34.77 13.29 64 358723 3973 79381628
Shock haemorrhagic 34.47 13.29 24 358763 20036 79365565
Throat tightness 34.39 13.29 45 358742 27862 79357739
Dizziness 34.39 13.29 2782 356005 523659 78861942
Inflammatory marker increased 34.36 13.29 4 358783 10736 79374865
Dermatitis atopic 34.11 13.29 3 358784 10053 79375548
Hypotonia 34.07 13.29 8 358779 12862 79372739
Autoimmune hepatitis 33.95 13.29 6 358781 11777 79373824
Feeling hot 33.69 13.29 146 358641 59588 79326013
Activated partial thromboplastin time prolonged 33.65 13.29 11 358776 14217 79371384
Blood lactic acid increased 33.59 13.29 8 358779 12736 79372865
Lipase increased 33.57 13.29 16 358771 16450 79369151
Nystagmus 33.47 13.29 3 358784 9901 79375700
Endometrial adenocarcinoma 33.30 13.29 32 358755 1043 79384558
Platelet count abnormal 33.30 13.29 70 358717 4792 79380809
Peripheral venous disease 33.14 13.29 15 358772 15894 79369707
Hyperhidrosis 32.99 13.29 481 358306 151011 79234590
Performance status decreased 32.92 13.29 80 358707 6033 79379568
Heavy menstrual bleeding 32.84 13.29 11 358776 14000 79371601
Blood phosphorus increased 32.74 13.29 4 358783 10343 79375258
Nasal congestion 32.57 13.29 206 358581 76346 79309255
Muscle twitching 32.55 13.29 38 358749 24726 79360875
Heparin-induced thrombocytopenia 32.54 13.29 3 358784 9679 79375922
Acidosis 32.20 13.29 25 358762 19737 79365864
Gastrointestinal haemorrhage 32.17 13.29 469 358318 147250 79238351
Pancreatitis 32.10 13.29 179 358608 68396 79317205
Pregnancy of partner 32.05 13.29 18 358769 247 79385354
Cardiomegaly 31.96 13.29 43 358744 26309 79359292
Malaise 31.87 13.29 1841 356946 488028 78897573
Bradyphrenia 31.58 13.29 5 358782 10635 79374966
Oliguria 31.52 13.29 17 358770 16292 79369309
Venous thrombosis limb 31.50 13.29 65 358722 4392 79381209
Ejection fraction decreased 31.30 13.29 68 358719 34509 79351092
Tardive dyskinesia 31.30 13.29 5 358782 10566 79375035
Eye disorder 31.06 13.29 196 358591 23216 79362385
Irritability 30.95 13.29 89 358698 41055 79344546
Impaired quality of life 30.86 13.29 13 358774 14373 79371228
Coronary artery disease 30.60 13.29 171 358616 65303 79320298
Breast cancer female 30.59 13.29 7 358780 11454 79374147
Injection site induration 30.57 13.29 4 358783 9815 79375786
Hepatitis cholestatic 30.56 13.29 12 358775 13840 79371761
Throat irritation 30.49 13.29 89 358698 40857 79344744
Clavicle fracture 29.92 13.29 63 358724 4318 79381283
Rhinitis allergic 29.88 13.29 9 358778 12260 79373341
Salmonellosis 29.76 13.29 39 358748 1799 79383802
Asphyxia 29.65 13.29 8 358779 11712 79373889
Flatulence 29.45 13.29 308 358479 42416 79343185
Dyslipidaemia 29.32 13.29 8 358779 11625 79373976
Hyperthyroidism 29.28 13.29 34 358753 22175 79363426
Blood pressure decreased 29.20 13.29 296 358491 99170 79286431
Cardiac arrest 29.14 13.29 572 358215 171524 79214077
Scar 29.14 13.29 16 358771 15180 79370421
Infusion site erythema 29.11 13.29 4 358783 9456 79376145
Aphasia 29.01 13.29 110 358677 46622 79338979
Disorientation 28.77 13.29 165 358622 62611 79322990
Bone density decreased 28.73 13.29 12 358775 13335 79372266
Complication associated with device 28.68 13.29 22 358765 17474 79368127
Left ventricular dysfunction 28.49 13.29 27 358760 19334 79366267
Myasthenia gravis 28.47 13.29 6 358781 10393 79375208
Pulmonary sepsis 28.46 13.29 56 358731 3656 79381945
Cardiac murmur 28.45 13.29 18 358769 15806 79369795
Morganella infection 28.40 13.29 30 358757 1097 79384504
Squamous cell carcinoma of lung 28.40 13.29 43 358744 2271 79383330
Parainfluenzae virus infection 28.12 13.29 72 358715 5610 79379991
Angina unstable 28.10 13.29 20 358767 16507 79369094
Systemic infection 28.02 13.29 5 358782 9747 79375854
Dyspnoea 28.00 13.29 3403 355384 853622 78531979
Exposure to toxic agent 27.88 13.29 4 358783 9154 79376447
Movement disorder 27.79 13.29 50 358737 27209 79358392
Nightmare 27.67 13.29 46 358741 25815 79359786
Myocardial ischaemia 27.67 13.29 45 358742 25474 79360127
Anger 27.60 13.29 22 358765 17140 79368461
Myeloma cast nephropathy 27.54 13.29 14 358773 155 79385446
White blood cell count 27.48 13.29 15 358772 194 79385407
Mouth ulceration 27.48 13.29 85 358702 38309 79347292
Drug tolerance decreased 27.41 13.29 12 358775 12966 79372635
Nodule 27.40 13.29 38 358749 22956 79362645
Stomatitis 27.27 13.29 480 358307 146277 79239324
Exposure via body fluid 27.24 13.29 18 358769 336 79385265
Squamous cell carcinoma of the hypopharynx 27.24 13.29 8 358779 14 79385587
Human chorionic gonadotropin abnormal 27.24 13.29 8 358779 14 79385587
Incorrect product administration duration 27.21 13.29 10 358777 12012 79373589
Polyneuropathy 27.12 13.29 194 358593 23957 79361644
Blood test 27.11 13.29 7 358780 5 79385596
Intracranial pressure increased 26.87 13.29 3 358784 8319 79377282
Post transplant lymphoproliferative disorder 26.87 13.29 9 358778 11455 79374146
Dysphagia 26.87 13.29 387 358400 121749 79263852
Neutrophil count abnormal 26.80 13.29 53 358734 3473 79382128
Toxic encephalopathy 26.78 13.29 9 358778 11431 79374170
Prescribed underdose 26.76 13.29 58 358729 29456 79356145
Device occlusion 26.64 13.29 10 358777 11856 79373745
Gastritis 26.64 13.29 118 358669 47875 79337726
Disseminated intravascular coagulation 26.62 13.29 78 358709 35764 79349837
Photophobia 26.45 13.29 32 358755 20496 79365105
Ataxia 26.37 13.29 45 358742 24994 79360607
Hiatus hernia 26.33 13.29 40 358747 23272 79362329
Duodenal ulcer 26.30 13.29 21 358766 16348 79369253
Tenderness 26.29 13.29 41 358746 23601 79362000
Catatonia 26.25 13.29 4 358783 8752 79376849
Urinary incontinence 26.24 13.29 95 358692 40814 79344787
Venous thrombosis 26.20 13.29 81 358706 7035 79378566
Affect lability 26.11 13.29 9 358778 11250 79374351
Skin plaque 25.96 13.29 8 358779 10737 79374864
Plasma cell myeloma in remission 25.92 13.29 8 358779 18 79385583
Nerve injury 25.86 13.29 97 358690 9295 79376306
Haematotoxicity 25.85 13.29 138 358649 15381 79370220
Muscular weakness 25.79 13.29 539 358248 160190 79225411
Bradykinesia 25.72 13.29 3 358784 8040 79377561
Atrioventricular block first degree 25.67 13.29 12 358775 12479 79373122
Vasculitis 25.63 13.29 46 358741 25056 79360545
Spinal osteoarthritis 25.62 13.29 23 358764 16904 79368697
Febrile neutropenia 25.60 13.29 1278 357509 229721 79155880
Eye movement disorder 25.59 13.29 3 358784 8008 79377593
Neuralgia 25.58 13.29 246 358541 33138 79352463
Pneumonia viral 25.57 13.29 95 358692 9063 79376538
Increased tendency to bruise 25.51 13.29 104 358683 10360 79375241
Myopathy 25.50 13.29 33 358754 20530 79365071
Ulcer 25.47 13.29 61 358726 29911 79355690
Dysphonia 25.39 13.29 378 358409 56494 79329107
Traumatic fracture 25.35 13.29 27 358760 997 79384604
Respiratory distress 25.33 13.29 156 358631 58183 79327418
Swollen tongue 25.28 13.29 102 358685 42468 79343133
Food poisoning 25.25 13.29 62 358725 4707 79380894
Frequent bowel movements 25.19 13.29 60 358727 29479 79356122
Wrong product administered 25.08 13.29 5 358782 9007 79376594
Febrile infection 25.07 13.29 50 358737 3296 79382305
Bronchospasm 24.98 13.29 46 358741 24813 79360788
Cytogenetic abnormality 24.96 13.29 28 358759 1097 79384504
Ketoacidosis 24.94 13.29 3 358784 7851 79377750
Protein total abnormal 24.93 13.29 21 358766 574 79385027
Haemodialysis 24.84 13.29 27 358760 18141 79367460
Palmar-plantar erythrodysaesthesia syndrome 24.68 13.29 72 358715 33062 79352539
Glomerular filtration rate decreased 24.65 13.29 40 358747 22662 79362939
Cholangiocarcinoma 24.51 13.29 42 358745 2464 79383137
Bladder transitional cell carcinoma stage 0 24.49 13.29 12 358775 122 79385479
Blood immunoglobulin A increased 24.48 13.29 26 358761 957 79384644
Musculoskeletal chest pain 24.46 13.29 193 358594 24571 79361030
Abdominal pain lower 24.46 13.29 68 358719 31714 79353887
Inappropriate antidiuretic hormone secretion 24.45 13.29 51 358736 26262 79359339
Colitis microscopic 24.30 13.29 9 358778 10759 79374842
Cholecystitis infective 24.24 13.29 46 358741 2923 79382678
Adrenal insufficiency 24.19 13.29 58 358729 28429 79357172
Bile acid malabsorption 24.14 13.29 14 358773 205 79385396
Muscle strain 24.12 13.29 96 358691 9459 79376142
Ventricular hypokinesia 24.11 13.29 6 358781 9273 79376328
Hepatic cytolysis 24.08 13.29 54 358733 27097 79358504
Paraproteinaemia 24.08 13.29 18 358769 412 79385189
Pulmonary function test decreased 24.05 13.29 3 358784 7634 79377967
Mania 24.02 13.29 28 358759 18232 79367369
Subarachnoid haemorrhage 23.94 13.29 46 358741 24419 79361182
Blood potassium abnormal 23.94 13.29 47 358740 3063 79382538
Hepatitis B reactivation 23.88 13.29 71 358716 6037 79379564
Viral upper respiratory tract infection 23.85 13.29 92 358695 8934 79376667
Walking aid user 23.73 13.29 8 358779 10140 79375461
Metabolic disorder 23.69 13.29 6 358781 9164 79376437
Gastric ulcer 23.60 13.29 76 358711 33829 79351772
Posterior reversible encephalopathy syndrome 23.53 13.29 52 358735 26229 79359372
Exfoliative rash 23.51 13.29 53 358734 3806 79381795
Prostate cancer 23.48 13.29 241 358546 33027 79352574
Deformity 23.48 13.29 7 358780 9598 79376003
Orthopnoea 23.45 13.29 8 358779 10065 79375536
Gastrointestinal infection 23.41 13.29 108 358679 11353 79374248
Peritonitis bacterial 23.33 13.29 7 358780 9560 79376041
Exercise tolerance decreased 23.31 13.29 6 358781 9065 79376536
Joint effusion 23.29 13.29 28 358759 17986 79367615
Pneumonia aspiration 23.25 13.29 191 358596 66776 79318825
Oral herpes 23.23 13.29 56 358731 27398 79358203
Colorectal adenocarcinoma 23.21 13.29 17 358770 377 79385224
Haemoptysis 23.15 13.29 152 358635 55847 79329754
Exostosis 23.11 13.29 25 358762 16833 79368768
Multiple organ dysfunction syndrome 23.07 13.29 391 358396 119855 79265746
Product prescribing issue 22.93 13.29 54 358733 3991 79381610
Sickle cell anaemia with crisis 22.90 13.29 4 358783 7918 79377683
Intestinal obstruction 22.89 13.29 295 358492 42725 79342876
Spinal operation 22.88 13.29 4 358783 7913 79377688
Chalazion 22.85 13.29 19 358768 510 79385091
Cholecystitis chronic 22.83 13.29 8 358779 9898 79375703
Transitional cell carcinoma 22.80 13.29 41 358746 2500 79383101
Hypercapnia 22.79 13.29 6 358781 8929 79376672
Metastases to central nervous system 22.76 13.29 24 358763 16351 79369250
Electrocardiogram ST segment elevation 22.67 13.29 5 358782 8392 79377209
Respiratory acidosis 22.65 13.29 11 358776 11189 79374412
Gastroenteritis viral 22.62 13.29 190 358597 24641 79360960
Superficial spreading melanoma stage unspecified 22.56 13.29 15 358772 283 79385318
Pseudomonas infection 22.54 13.29 37 358750 20866 79364735
Alanine aminotransferase abnormal 22.53 13.29 6 358781 8861 79376740
Sarcoidosis 22.43 13.29 5 358782 8330 79377271
Rebound effect 22.36 13.29 3 358784 7223 79378378
Precursor B-lymphoblastic lymphoma 22.31 13.29 7 358780 17 79385584
Pathogen resistance 22.30 13.29 19 358768 14323 79371278
Granuloma 22.28 13.29 5 358782 8292 79377309
Osteopenia 22.23 13.29 30 358757 18334 79367267
Hypertriglyceridaemia 22.21 13.29 15 358772 12725 79372876
Vertebral lesion 22.16 13.29 20 358767 601 79385000
Varicophlebitis 22.03 13.29 7 358780 18 79385583
Amenorrhoea 21.98 13.29 4 358783 7688 79377913
Gastrointestinal stromal tumour 21.98 13.29 33 358754 1730 79383871
Salivary hypersecretion 21.93 13.29 19 358768 14205 79371396
Pneumonia parainfluenzae viral 21.85 13.29 15 358772 299 79385302
Marasmus 21.81 13.29 25 358762 1003 79384598
Peripheral sensory neuropathy 21.78 13.29 116 358671 12917 79372684
Polyarthritis 21.77 13.29 14 358773 12188 79373413
Sinus bradycardia 21.76 13.29 51 358736 25196 79360405
Eosinophil count increased 21.68 13.29 27 358760 17078 79368523
Injection site discolouration 21.67 13.29 4 358783 7610 79377991
Central nervous system lesion 21.67 13.29 17 358770 13351 79372250
Post procedural haemorrhage 21.63 13.29 18 358769 13726 79371875
Rectal haemorrhage 21.60 13.29 229 358558 76071 79309530
Breast cancer stage II 21.59 13.29 5 358782 8115 79377486
Psychiatric symptom 21.59 13.29 3 358784 7032 79378569
Fistula 21.56 13.29 16 358771 12924 79372677
Oesophageal squamous cell carcinoma 21.50 13.29 18 358769 488 79385113
Atypical pneumonia 21.24 13.29 72 358715 6564 79379037
Renal injury 21.16 13.29 27 358760 16900 79368701
Meningitis aseptic 21.15 13.29 3 358784 6925 79378676
Type 1 diabetes mellitus 21.11 13.29 3 358784 6916 79378685
Appendix disorder 21.11 13.29 32 358755 1692 79383909
Pneumonia legionella 21.10 13.29 43 358744 2879 79382722
Cholecystectomy 21.09 13.29 8 358779 9424 79376177
Stress cardiomyopathy 21.06 13.29 12 358775 11154 79374447
Acute erythroid leukaemia 20.93 13.29 14 358773 267 79385334
Stupor 20.92 13.29 3 358784 6869 79378732
Squamous cell carcinoma of the oral cavity 20.83 13.29 18 358769 510 79385091
Hyperammonaemia 20.81 13.29 12 358775 11081 79374520
Pain in jaw 20.77 13.29 122 358665 46029 79339572
Blood lactate dehydrogenase increased 20.73 13.29 98 358689 39072 79346529
Hepatomegaly 20.73 13.29 33 358754 18841 79366760
Diverticular perforation 20.71 13.29 66 358721 5827 79379774
Dislocation of vertebra 20.66 13.29 5 358782 7875 79377726
Hydronephrosis 20.64 13.29 29 358758 17425 79368176
Abdominal tenderness 20.54 13.29 11 358776 10583 79375018
Blood thyroid stimulating hormone increased 20.46 13.29 9 358778 9699 79375902
Nasal abscess 20.38 13.29 12 358775 181 79385420
Blood calcium decreased 20.36 13.29 226 358561 31593 79354008
Hepatic fibrosis 20.34 13.29 4 358783 7276 79378325
Tuberculosis 20.32 13.29 23 358764 15175 79370426
Pulse absent 20.32 13.29 10 358777 10093 79375508
Hepatitis fulminant 20.27 13.29 4 358783 7258 79378343
Pneumonia respiratory syncytial viral 20.25 13.29 33 358754 1857 79383744
Oesophagitis 20.19 13.29 50 358737 24239 79361362
Normochromic normocytic anaemia 20.07 13.29 5 358782 7722 79377879
Neuroendocrine carcinoma of the skin 19.95 13.29 27 358760 1285 79384316
Kidney infection 19.80 13.29 167 358620 21684 79363917
Liver function test decreased 19.78 13.29 11 358776 148 79385453
Tongue oedema 19.70 13.29 4 358783 7113 79378488
Abortion induced 19.67 13.29 4 358783 7105 79378496
Enterococcal infection 19.56 13.29 25 358762 15635 79369966
Brain injury 19.50 13.29 14 358773 11503 79374098
Bundle branch block left 19.49 13.29 14 358773 11499 79374102
Expired product administered 19.44 13.29 4 358783 7047 79378554
Kidney transplant rejection 19.34 13.29 11 358776 10235 79375366
Hyperaesthesia 19.24 13.29 16 358771 12206 79373395
Immunoglobulins increased 19.19 13.29 19 358768 643 79384958
Papule 19.17 13.29 75 358712 7332 79378269
Angina pectoris 19.14 13.29 145 358642 51587 79334014
Spinal column injury 19.13 13.29 35 358752 2163 79383438
Campylobacter gastroenteritis 19.12 13.29 27 358760 1338 79384263
Finger deformity 19.10 13.29 5 358782 7469 79378132
Epstein-Barr virus infection 19.08 13.29 22 358765 14394 79371207
Scoliosis 19.06 13.29 5 358782 7459 79378142
Cardiac valve disease 19.00 13.29 63 358724 5678 79379923
Emotional disorder 18.99 13.29 22 358765 14365 79371236
N-terminal prohormone brain natriuretic peptide decreased 18.98 13.29 7 358780 32 79385569
Intentional dose omission 18.86 13.29 8 358779 8809 79376792
Apnoea 18.82 13.29 15 358772 11689 79373912
Cerebellar haemangioma 18.67 13.29 9 358778 88 79385513
Vitamin D deficiency 18.67 13.29 22 358765 14257 79371344
Gastritis erosive 18.61 13.29 13 358774 10834 79374767
Infusion site swelling 18.59 13.29 6 358781 7820 79377781
Nasal polyps 18.54 13.29 5 358782 7322 79378279
Hyperbilirubinaemia 18.47 13.29 53 358734 24465 79361136
Device failure 18.45 13.29 3 358784 6258 79379343
Light chain disease 18.44 13.29 12 358775 218 79385383
Hyperproteinaemia 18.39 13.29 11 358776 171 79385430
Skin fissures 18.35 13.29 19 358768 13054 79372547
Oedema 18.31 13.29 404 358383 119176 79266425
Optic neuritis 18.29 13.29 10 358777 9510 79376091
Ear swelling 18.19 13.29 29 358758 1602 79383999
Blood chloride decreased 18.18 13.29 7 358780 8170 79377431
POEMS syndrome 18.16 13.29 7 358780 37 79385564
Hypernatraemia 18.12 13.29 23 358764 14428 79371173
Diverticulum intestinal 18.10 13.29 8 358779 8597 79377004
Respiratory tract infection viral 18.09 13.29 51 358736 4208 79381393
5q minus syndrome 18.07 13.29 13 358774 280 79385321
Acute respiratory distress syndrome 18.02 13.29 120 358667 43947 79341654
Sternal fracture 18.00 13.29 37 358750 2493 79383108
Musculoskeletal discomfort 17.96 13.29 39 358748 19796 79365805
Granulocytopenia 17.95 13.29 15 358772 11416 79374185
Thrombophlebitis 17.92 13.29 66 358721 6269 79379332
Lip dry 17.86 13.29 26 358761 15392 79370209
Rash erythematous 17.86 13.29 362 358425 57407 79328194
Portal hypertension 17.70 13.29 5 358782 7103 79378498
Tricuspid valve incompetence 17.65 13.29 39 358748 19673 79365928
Large intestine infection 17.63 13.29 42 358745 3127 79382474
Pleurisy viral 17.63 13.29 4 358783 0 79385601
Disease recurrence 17.60 13.29 121 358666 43988 79341613
Bundle branch block right 17.38 13.29 15 358772 11236 79374365
Neutrophilia 17.36 13.29 7 358780 7944 79377657
Nausea 17.26 13.29 3929 354858 953267 78432334
Vaginal discharge 17.25 13.29 6 358781 7457 79378144
Prothrombin time prolonged 17.22 13.29 31 358756 16868 79368733
Crepitations 17.19 13.29 12 358775 10005 79375596
Body temperature increased 17.16 13.29 123 358664 44297 79341304
Pneumonia streptococcal 17.06 13.29 38 358749 2707 79382894
Proctitis 17.02 13.29 4 358783 6428 79379173
Endophthalmitis 17.01 13.29 4 358783 6424 79379177
Depressive symptom 16.99 13.29 4 358783 6419 79379182
Lower gastrointestinal haemorrhage 16.96 13.29 29 358758 16096 79369505
Testicular disorder 16.94 13.29 12 358775 252 79385349
H1N1 influenza 16.94 13.29 36 358751 2483 79383118
Body dysmorphic disorder 16.87 13.29 13 358774 312 79385289
Immunosuppression 16.87 13.29 107 358680 12696 79372905
Pityriasis rubra pilaris 16.86 13.29 9 358778 111 79385490
Occult blood positive 16.85 13.29 5 358782 6878 79378723
Blood stem cell harvest failure 16.79 13.29 9 358778 112 79385489
Polyuria 16.73 13.29 26 358761 14988 79370613
Superficial spreading melanoma stage I 16.71 13.29 6 358781 25 79385576
Pulmonary congestion 16.68 13.29 64 358723 27036 79358565
Sexual dysfunction 16.68 13.29 7 358780 7756 79377845
Visual acuity reduced 16.63 13.29 72 358715 29397 79356204
Therapy non-responder 16.59 13.29 538 358249 91767 79293834
Oesophageal adenocarcinoma 16.57 13.29 20 358767 848 79384753
Diffuse large B-cell lymphoma recurrent 16.54 13.29 49 358738 4158 79381443
Vision blurred 16.47 13.29 607 358180 105291 79280310
Laryngeal oedema 16.42 13.29 8 358779 8121 79377480
Hysterectomy 16.41 13.29 4 358783 6268 79379333
Immunoglobulins decreased 16.40 13.29 27 358760 1533 79384068
Gynaecomastia 16.38 13.29 7 358780 7674 79377927
Humerus fracture 16.33 13.29 84 358703 9229 79376372
Atelectasis 16.32 13.29 82 358705 32175 79353426
Tension headache 16.32 13.29 6 358781 7205 79378396
Invasive lobular breast carcinoma 16.30 13.29 18 358769 693 79384908
Renal neoplasm 16.26 13.29 31 358756 1977 79383624
Psychomotor hyperactivity 16.21 13.29 32 358755 16817 79368784
Blood iron decreased 16.20 13.29 122 358665 15312 79370289
JC virus CSF test positive 16.15 13.29 10 358777 166 79385435
Hyperglycaemia 16.12 13.29 221 358566 70114 79315487
Pneumonia bacterial 16.09 13.29 145 358642 19186 79366415
Haemorrhage intracranial 16.03 13.29 62 358725 26131 79359470
Inflammatory bowel disease 16.01 13.29 3 358784 5648 79379953
Hepatitis B DNA increased 15.92 13.29 19 358768 796 79384805
Wheelchair user 15.87 13.29 4 358783 6128 79379473
Haematochezia 15.85 13.29 288 358499 87357 79298244
Neoplasm 15.83 13.29 82 358705 9034 79376567
SARS-CoV-2 sepsis 15.81 13.29 9 358778 127 79385474
Wound dehiscence 15.77 13.29 5 358782 6590 79379011
Product physical issue 15.75 13.29 48 358739 4137 79381464
Frustration tolerance decreased 15.74 13.29 7 358780 7495 79378106
Chest pain 15.71 13.29 1076 357711 281228 79104373
Pre-existing condition improved 15.67 13.29 3 358784 5560 79380041
Blood pressure systolic decreased 15.66 13.29 16 358771 11060 79374541
White blood cells urine positive 15.65 13.29 4 358783 6071 79379530
Nail discolouration 15.62 13.29 39 358748 2992 79382609
Weight decreased 15.60 13.29 1826 356961 353372 79032229
Arteriosclerosis 15.56 13.29 37 358750 18190 79367411
Eyelid ptosis 15.56 13.29 16 358771 11028 79374573
Areflexia 15.55 13.29 3 358784 5531 79380070
Cerebral infarction 15.53 13.29 131 358656 45545 79340056
Vascular device infection 15.51 13.29 14 358773 10262 79375339
Iron deficiency 15.51 13.29 15 358772 10639 79374962
Feeling jittery 15.51 13.29 105 358682 12736 79372865
Scleroderma 15.46 13.29 3 358784 5507 79380094
Hepatic amyloidosis 15.41 13.29 4 358783 3 79385598
Necrotic lymphadenopathy 15.40 13.29 8 358779 93 79385508
Ventricular hypertrophy 15.32 13.29 6 358781 6932 79378669
Female genital tract fistula 15.26 13.29 4 358783 5971 79379630
Lung squamous cell carcinoma stage IV 15.22 13.29 7 358780 61 79385540
Gastrointestinal fungal infection 15.16 13.29 15 358772 507 79385094
Vertigo 15.15 13.29 219 358568 68863 79316738
Abdominal distension 15.11 13.29 416 358371 119234 79266367
Drooling 15.11 13.29 4 358783 5930 79379671
Blood albumin decreased 15.09 13.29 57 358730 24186 79361415
Red blood cell count abnormal 15.07 13.29 25 358762 1428 79384173
Lymphoma 15.07 13.29 132 358655 17328 79368273
Insomnia 15.06 13.29 1290 357497 243880 79141721
Sensory disturbance 15.06 13.29 28 358759 15049 79370552
Renal cyst 15.04 13.29 27 358760 14705 79370896
Dyspnoea at rest 15.03 13.29 7 358780 7295 79378306
Catheter site pain 15.01 13.29 3 358784 5393 79380208
Target skin lesion 14.99 13.29 9 358778 141 79385460
Photosensitivity reaction 14.96 13.29 47 358740 21080 79364521
Dysstasia 14.93 13.29 69 358718 27677 79357924
Apathy 14.92 13.29 22 358765 12955 79372646
Pneumothorax 14.91 13.29 71 358716 28252 79357349
Blood immunoglobulin E increased 14.91 13.29 4 358783 5878 79379723
Progressive multifocal leukoencephalopathy 14.91 13.29 150 358637 20450 79365151
Product dose omission in error 14.90 13.29 72 358715 7716 79377885
Food allergy 14.89 13.29 16 358771 10808 79374793
Hydrocephalus 14.83 13.29 11 358776 8889 79376712
Transitional cell cancer of the renal pelvis and ureter 14.74 13.29 7 358780 66 79385535
Behaviour disorder 14.72 13.29 5 358782 6308 79379293
Tendon disorder 14.62 13.29 7 358780 7179 79378422
Retroperitoneal haematoma 14.62 13.29 3 358784 5294 79380307
Hypersensitivity myocarditis 14.52 13.29 11 358776 257 79385344
Venoocclusive liver disease 14.49 13.29 19 358768 11752 79373849
Stem cell transplant 14.43 13.29 43 358744 3661 79381940
Blood pressure abnormal 14.40 13.29 129 358658 17040 79368561
Catheter site erythema 14.39 13.29 3 358784 5237 79380364
Pneumonia fungal 14.35 13.29 93 358694 11117 79374484
Intervertebral disc degeneration 14.32 13.29 31 358756 15754 79369847
Renal tubular necrosis 14.24 13.29 61 358726 24978 79360623
Encephalitis 14.23 13.29 28 358759 14732 79370869
Rash pustular 14.19 13.29 18 358769 11293 79374308
Acute biphenotypic leukaemia 14.15 13.29 9 358778 157 79385444
Meningitis pneumococcal 14.13 13.29 14 358773 474 79385127
JC virus infection 14.13 13.29 44 358743 3837 79381764
Sinus disorder 14.12 13.29 159 358628 22305 79363296
Drug tolerance 14.10 13.29 11 358776 8664 79376937
Lung squamous cell carcinoma stage III 14.09 13.29 5 358782 20 79385581
Gastric infection 14.08 13.29 43 358744 3710 79381891
Squamous cell carcinoma of head and neck 14.03 13.29 11 358776 271 79385330
Refractory cytopenia with unilineage dysplasia 14.01 13.29 19 358768 906 79384695
Retinitis 14.00 13.29 4 358783 5639 79379962
Self-medication 13.97 13.29 3 358784 5129 79380472
Dyspepsia 13.96 13.29 377 358410 108310 79277291
Heat illness 13.91 13.29 15 358772 562 79385039
Lymphoproliferative disorder 13.89 13.29 4 358783 5611 79379990
Rash maculo-papular 13.74 13.29 340 358447 55738 79329863
Retching 13.72 13.29 37 358750 17430 79368171
Blood glucose increased 13.69 13.29 403 358384 114572 79271029
Ecchymosis 13.69 13.29 30 358757 15176 79370425
Deafness neurosensory 13.61 13.29 7 358780 6891 79378710
Pain in extremity 13.59 13.29 1434 357353 363104 79022497
Head injury 13.55 13.29 240 358547 37129 79348472
Bipolar disorder 13.54 13.29 9 358778 7698 79377903
Proctalgia 13.52 13.29 15 358772 9986 79375615
Ischaemic cardiomyopathy 13.50 13.29 9 358778 7686 79377915
Hypertensive crisis 13.47 13.29 48 358739 20722 79364879
Long QT syndrome 13.40 13.29 5 358782 5950 79379651
Oxygen consumption increased 13.37 13.29 3 358784 4976 79380625
Lymphocyte percentage decreased 13.36 13.29 3 358784 4973 79380628
Embolic pneumonia 13.36 13.29 7 358780 83 79385518
Retroperitoneal haemorrhage 13.34 13.29 4 358783 5466 79380135
Meningitis listeria 13.31 13.29 20 358767 1049 79384552
Pyelonephritis 13.30 13.29 47 358740 20341 79365260

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC L04AX04 ANTINEOPLASTIC AND IMMUNOMODULATING AGENTS
IMMUNOSUPPRESSANTS
IMMUNOSUPPRESSANTS
Other immunosuppressants
MeSH PA D020533 Angiogenesis Inhibitors
MeSH PA D000970 Antineoplastic Agents
MeSH PA D006131 Growth Inhibitors
MeSH PA D006133 Growth Substances
MeSH PA D007155 Immunologic Factors
FDA EPC N0000184014 Thalidomide Analog
CHEBI has role CHEBI:35610 antineoplastic agents
CHEBI has role CHEBI:48422 angiogenesis antagonist
CHEBI has role CHEBI:50846 Immunologic factor

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Follicular lymphoma indication 55150002
Multiple myeloma indication 109989006 DOID:9538
Myelodysplastic syndrome indication 109995007
Mantle cell lymphoma indication 443487006
Marginal zone lymphoma indication 447100004
Deep venous thrombosis contraindication 128053003
Impaired renal function disorder contraindication 197663003
Pulmonary thromboembolism contraindication 233935004
Pregnancy, function contraindication 289908002
Thrombocytopenic disorder contraindication 302215000 DOID:1588
Neutropenic disorder contraindication 303011007 DOID:1227
Thromboembolic disorder contraindication 371039008
Primary malignant neoplasm contraindication 372087000
Breastfeeding (mother) contraindication 413712001
Chemotherapy-Induced Hyperuricemia contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.17 acidic
pKa2 3.13 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
10MG REVLIMID CELGENE N021880 Dec. 27, 2005 RX CAPSULE ORAL 7189740 April 11, 2023 USE OF REVLIMID (LENALIDOMIDE) FOR TREATMENT OF PATIENTS WITH TRANSFUSION-DEPENDENT ANEMIA DUE TO LOW-OR INTERMEDIATE-1-RISK MYELODYSPLASTIC SYNDROMES ASSOCIATED WITH A DELETION 5Q ABNORMALITY WITH OR WITHOUT ADDITIONAL CYTOGENETIC ABNORMALITIES
10MG REVLIMID CELGENE N021880 Dec. 27, 2005 RX CAPSULE ORAL 8404717 April 11, 2023 USE OF REVLIMID (LENALIDOMIDE) FOR TREATMENT OF PATIENTS WITH TRANSFUSION-DEPENDENT ANEMIA DUE TO LOW-OR INTERMEDIATE-1-RISK MYELODYSPLASTIC SYNDROMES ASSOCIATED WITH A DELETION 5Q ABNORMALITY WITH OR WITHOUT ADDITIONAL CYTOGENETIC ABNORMALITIES
10MG REVLIMID CELGENE N021880 Dec. 27, 2005 RX CAPSULE ORAL 9056120 April 11, 2023 USE OF REVLIMID (LENALIDOMIDE) FOR TREATMENT OF PATIENTS WITH TRANSFUSION-DEPENDENT ANEMIA DUE TO LOW-OR INTERMEDIATE-1-RISK MYELODYSPLASTIC SYNDROMES ASSOCIATED WITH A DELETION 5Q ABNORMALITY WITH OR WITHOUT ADDITIONAL CYTOGENETIC ABNORMALITIES
15MG REVLIMID CELGENE N021880 June 29, 2006 RX CAPSULE ORAL 7189740 April 11, 2023 USE OF REVLIMID (LENALIDOMIDE) FOR TREATMENT OF PATIENTS WITH TRANSFUSION-DEPENDENT ANEMIA DUE TO LOW-OR INTERMEDIATE-1-RISK MYELODYSPLASTIC SYNDROMES ASSOCIATED WITH A DELETION 5Q ABNORMALITY WITH OR WITHOUT ADDITIONAL CYTOGENETIC ABNORMALITIES
15MG REVLIMID CELGENE N021880 June 29, 2006 RX CAPSULE ORAL 8404717 April 11, 2023 USE OF REVLIMID (LENALIDOMIDE) FOR TREATMENT OF PATIENTS WITH TRANSFUSION-DEPENDENT ANEMIA DUE TO LOW-OR INTERMEDIATE-1-RISK MYELODYSPLASTIC SYNDROMES ASSOCIATED WITH A DELETION 5Q ABNORMALITY WITH OR WITHOUT ADDITIONAL CYTOGENETIC ABNORMALITIES
15MG REVLIMID CELGENE N021880 June 29, 2006 RX CAPSULE ORAL 9056120 April 11, 2023 USE OF REVLIMID (LENALIDOMIDE) FOR TREATMENT OF PATIENTS WITH TRANSFUSION-DEPENDENT ANEMIA DUE TO LOW-OR INTERMEDIATE-1-RISK MYELODYSPLASTIC SYNDROMES ASSOCIATED WITH A DELETION 5Q ABNORMALITY WITH OR WITHOUT ADDITIONAL CYTOGENETIC ABNORMALITIES
2.5MG REVLIMID CELGENE N021880 Dec. 21, 2011 RX CAPSULE ORAL 7189740 April 11, 2023 USE OF REVLIMID (LENALIDOMIDE) FOR TREATMENT OF PATIENTS WITH TRANSFUSION-DEPENDENT ANEMIA DUE TO LOW-OR INTERMEDIATE-1-RISK MYELODYSPLASTIC SYNDROMES ASSOCIATED WITH A DELETION 5Q ABNORMALITY WITH OR WITHOUT ADDITIONAL CYTOGENETIC ABNORMALITIES
2.5MG REVLIMID CELGENE N021880 Dec. 21, 2011 RX CAPSULE ORAL 8404717 April 11, 2023 USE OF REVLIMID (LENALIDOMIDE) FOR TREATMENT OF PATIENTS WITH TRANSFUSION-DEPENDENT ANEMIA DUE TO LOW-OR INTERMEDIATE-1-RISK MYELODYSPLASTIC SYNDROMES ASSOCIATED WITH A DELETION 5Q ABNORMALITY WITH OR WITHOUT ADDITIONAL CYTOGENETIC ABNORMALITIES
2.5MG REVLIMID CELGENE N021880 Dec. 21, 2011 RX CAPSULE ORAL 9056120 April 11, 2023 USE OF REVLIMID (LENALIDOMIDE) FOR TREATMENT OF PATIENTS WITH TRANSFUSION-DEPENDENT ANEMIA DUE TO LOW-OR INTERMEDIATE-1-RISK MYELODYSPLASTIC SYNDROMES ASSOCIATED WITH A DELETION 5Q ABNORMALITY WITH OR WITHOUT ADDITIONAL CYTOGENETIC ABNORMALITIES
20MG REVLIMID CELGENE N021880 June 5, 2013 RX CAPSULE ORAL 7189740 April 11, 2023 USE OF REVLIMID (LENALIDOMIDE) FOR TREATMENT OF PATIENTS WITH TRANSFUSION-DEPENDENT ANEMIA DUE TO LOW-OR INTERMEDIATE-1-RISK MYELODYSPLASTIC SYNDROMES ASSOCIATED WITH A DELETION 5Q ABNORMALITY WITH OR WITHOUT ADDITIONAL CYTOGENETIC ABNORMALITIES
20MG REVLIMID CELGENE N021880 June 5, 2013 RX CAPSULE ORAL 8404717 April 11, 2023 USE OF REVLIMID (LENALIDOMIDE) FOR TREATMENT OF PATIENTS WITH TRANSFUSION-DEPENDENT ANEMIA DUE TO LOW-OR INTERMEDIATE-1-RISK MYELODYSPLASTIC SYNDROMES ASSOCIATED WITH A DELETION 5Q ABNORMALITY WITH OR WITHOUT ADDITIONAL CYTOGENETIC ABNORMALITIES
20MG REVLIMID CELGENE N021880 June 5, 2013 RX CAPSULE ORAL 9056120 April 11, 2023 USE OF REVLIMID (LENALIDOMIDE) FOR TREATMENT OF PATIENTS WITH TRANSFUSION-DEPENDENT ANEMIA DUE TO LOW-OR INTERMEDIATE-1-RISK MYELODYSPLASTIC SYNDROMES ASSOCIATED WITH A DELETION 5Q ABNORMALITY WITH OR WITHOUT ADDITIONAL CYTOGENETIC ABNORMALITIES
25MG REVLIMID CELGENE N021880 June 29, 2006 RX CAPSULE ORAL 7189740 April 11, 2023 USE OF REVLIMID (LENALIDOMIDE) FOR TREATMENT OF PATIENTS WITH TRANSFUSION-DEPENDENT ANEMIA DUE TO LOW-OR INTERMEDIATE-1-RISK MYELODYSPLASTIC SYNDROMES ASSOCIATED WITH A DELETION 5Q ABNORMALITY WITH OR WITHOUT ADDITIONAL CYTOGENETIC ABNORMALITIES
25MG REVLIMID CELGENE N021880 June 29, 2006 RX CAPSULE ORAL 8404717 April 11, 2023 USE OF REVLIMID (LENALIDOMIDE) FOR TREATMENT OF PATIENTS WITH TRANSFUSION-DEPENDENT ANEMIA DUE TO LOW-OR INTERMEDIATE-1-RISK MYELODYSPLASTIC SYNDROMES ASSOCIATED WITH A DELETION 5Q ABNORMALITY WITH OR WITHOUT ADDITIONAL CYTOGENETIC ABNORMALITIES
25MG REVLIMID CELGENE N021880 June 29, 2006 RX CAPSULE ORAL 9056120 April 11, 2023 USE OF REVLIMID (LENALIDOMIDE) FOR TREATMENT OF PATIENTS WITH TRANSFUSION-DEPENDENT ANEMIA DUE TO LOW-OR INTERMEDIATE-1-RISK MYELODYSPLASTIC SYNDROMES ASSOCIATED WITH A DELETION 5Q ABNORMALITY WITH OR WITHOUT ADDITIONAL CYTOGENETIC ABNORMALITIES
5MG REVLIMID CELGENE N021880 Dec. 27, 2005 RX CAPSULE ORAL 7189740 April 11, 2023 USE OF REVLIMID (LENALIDOMIDE) FOR TREATMENT OF PATIENTS WITH TRANSFUSION-DEPENDENT ANEMIA DUE TO LOW-OR INTERMEDIATE-1-RISK MYELODYSPLASTIC SYNDROMES ASSOCIATED WITH A DELETION 5Q ABNORMALITY WITH OR WITHOUT ADDITIONAL CYTOGENETIC ABNORMALITIES
5MG REVLIMID CELGENE N021880 Dec. 27, 2005 RX CAPSULE ORAL 8404717 April 11, 2023 USE OF REVLIMID (LENALIDOMIDE) FOR TREATMENT OF PATIENTS WITH TRANSFUSION-DEPENDENT ANEMIA DUE TO LOW-OR INTERMEDIATE-1-RISK MYELODYSPLASTIC SYNDROMES ASSOCIATED WITH A DELETION 5Q ABNORMALITY WITH OR WITHOUT ADDITIONAL CYTOGENETIC ABNORMALITIES
5MG REVLIMID CELGENE N021880 Dec. 27, 2005 RX CAPSULE ORAL 9056120 April 11, 2023 USE OF REVLIMID (LENALIDOMIDE) FOR TREATMENT OF PATIENTS WITH TRANSFUSION-DEPENDENT ANEMIA DUE TO LOW-OR INTERMEDIATE-1-RISK MYELODYSPLASTIC SYNDROMES ASSOCIATED WITH A DELETION 5Q ABNORMALITY WITH OR WITHOUT ADDITIONAL CYTOGENETIC ABNORMALITIES
10MG REVLIMID CELGENE N021880 Dec. 27, 2005 RX CAPSULE ORAL 8530498 May 15, 2023 USE OF REVLIMID (LENALIDOMIDE) FOR THE TREATMENT OF PATIENTS WITH MULTIPLE MYELOMA, IN COMBINATION WITH DEXAMETHASONE
10MG REVLIMID CELGENE N021880 Dec. 27, 2005 RX CAPSULE ORAL 8648095 May 15, 2023 USE OF REVLIMID (LENALIDOMIDE) FOR THE TREATMENT OF PATIENTS WITH MULTIPLE MYELOMA, IN COMBINATION WITH DEXAMETHASONE
10MG REVLIMID CELGENE N021880 Dec. 27, 2005 RX CAPSULE ORAL 9101621 May 15, 2023 USE OF REVLIMID (LENALIDOMIDE) FOR THE TREATMENT OF PATIENTS WITH MULTIPLE MYELOMA, AS MAINTENANCE FOLLOWING AUTOLOGOUS HEMATOPOIETIC STEM CELL TRANSPLANTATION (AUTO-HSCT)
10MG REVLIMID CELGENE N021880 Dec. 27, 2005 RX CAPSULE ORAL 9101622 May 15, 2023 USE OF REVLIMID (LENALIDOMIDE) FOR THE TREATMENT OF PATIENTS WITH MULTIPLE MYELOMA, IN COMBINATION WITH DEXAMETHASONE, WHEREIN THOSE PATIENTS HAVE NOT RECEIVED PREVIOUS TREATMENT FOR MULTIPLE MYELOMA
10MG REVLIMID CELGENE N021880 Dec. 27, 2005 RX CAPSULE ORAL 9155730 May 15, 2023 USE OF REVLIMID (LENALIDOMIDE) FOR THE TREATMENT OF PREVIOUSLY TREATED FOLLICULAR LYMPHOMA IN COMBINATION WITH A RITUXIMAB PRODUCT
10MG REVLIMID CELGENE N021880 Dec. 27, 2005 RX CAPSULE ORAL 9393238 May 15, 2023 USE OF REVLIMID (LENALIDOMIDE) FOR THE TREATMENT OF PREVIOUSLY TREATED FOLLICULAR LYMPHOMA IN COMBINATION WITH A RITUXIMAB PRODUCT
15MG REVLIMID CELGENE N021880 June 29, 2006 RX CAPSULE ORAL 8530498 May 15, 2023 USE OF REVLIMID (LENALIDOMIDE) FOR THE TREATMENT OF PATIENTS WITH MULTIPLE MYELOMA, IN COMBINATION WITH DEXAMETHASONE
15MG REVLIMID CELGENE N021880 June 29, 2006 RX CAPSULE ORAL 8648095 May 15, 2023 USE OF REVLIMID (LENALIDOMIDE) FOR THE TREATMENT OF PATIENTS WITH MULTIPLE MYELOMA, IN COMBINATION WITH DEXAMETHASONE
15MG REVLIMID CELGENE N021880 June 29, 2006 RX CAPSULE ORAL 9101621 May 15, 2023 USE OF REVLIMID (LENALIDOMIDE) FOR THE TREATMENT OF PATIENTS WITH MULTIPLE MYELOMA, AS MAINTENANCE FOLLOWING AUTOLOGOUS HEMATOPOIETIC STEM CELL TRANSPLANTATION (AUTO-HSCT)
15MG REVLIMID CELGENE N021880 June 29, 2006 RX CAPSULE ORAL 9101622 May 15, 2023 USE OF REVLIMID (LENALIDOMIDE) FOR THE TREATMENT OF PATIENTS WITH MULTIPLE MYELOMA, IN COMBINATION WITH DEXAMETHASONE, WHEREIN THOSE PATIENTS HAVE NOT RECEIVED PREVIOUS TREATMENT FOR MULTIPLE MYELOMA
15MG REVLIMID CELGENE N021880 June 29, 2006 RX CAPSULE ORAL 9155730 May 15, 2023 USE OF REVLIMID (LENALIDOMIDE) FOR THE TREATMENT OF PREVIOUSLY TREATED FOLLICULAR LYMPHOMA IN COMBINATION WITH A RITUXIMAB PRODUCT
15MG REVLIMID CELGENE N021880 June 29, 2006 RX CAPSULE ORAL 9393238 May 15, 2023 USE OF REVLIMID (LENALIDOMIDE) FOR THE TREATMENT OF PREVIOUSLY TREATED FOLLICULAR LYMPHOMA IN COMBINATION WITH A RITUXIMAB PRODUCT
2.5MG REVLIMID CELGENE N021880 Dec. 21, 2011 RX CAPSULE ORAL 8530498 May 15, 2023 USE OF REVLIMID (LENALIDOMIDE) FOR THE TREATMENT OF PATIENTS WITH MULTIPLE MYELOMA, IN COMBINATION WITH DEXAMETHASONE
2.5MG REVLIMID CELGENE N021880 Dec. 21, 2011 RX CAPSULE ORAL 8648095 May 15, 2023 USE OF REVLIMID (LENALIDOMIDE) FOR THE TREATMENT OF PATIENTS WITH MULTIPLE MYELOMA, IN COMBINATION WITH DEXAMETHASONE
2.5MG REVLIMID CELGENE N021880 Dec. 21, 2011 RX CAPSULE ORAL 9101621 May 15, 2023 USE OF REVLIMID (LENALIDOMIDE) FOR THE TREATMENT OF PATIENTS WITH MULTIPLE MYELOMA, AS MAINTENANCE FOLLOWING AUTOLOGOUS HEMATOPOIETIC STEM CELL TRANSPLANTATION (AUTO-HSCT)
2.5MG REVLIMID CELGENE N021880 Dec. 21, 2011 RX CAPSULE ORAL 9101622 May 15, 2023 USE OF REVLIMID (LENALIDOMIDE) FOR THE TREATMENT OF PATIENTS WITH MULTIPLE MYELOMA, IN COMBINATION WITH DEXAMETHASONE, WHEREIN THOSE PATIENTS HAVE NOT RECEIVED PREVIOUS TREATMENT FOR MULTIPLE MYELOMA
2.5MG REVLIMID CELGENE N021880 Dec. 21, 2011 RX CAPSULE ORAL 9155730 May 15, 2023 USE OF REVLIMID (LENALIDOMIDE) FOR THE TREATMENT OF PREVIOUSLY TREATED FOLLICULAR LYMPHOMA IN COMBINATION WITH A RITUXIMAB PRODUCT
2.5MG REVLIMID CELGENE N021880 Dec. 21, 2011 RX CAPSULE ORAL 9393238 May 15, 2023 USE OF REVLIMID (LENALIDOMIDE) FOR THE TREATMENT OF PREVIOUSLY TREATED FOLLICULAR LYMPHOMA IN COMBINATION WITH A RITUXIMAB PRODUCT
20MG REVLIMID CELGENE N021880 June 5, 2013 RX CAPSULE ORAL 8530498 May 15, 2023 USE OF REVLIMID (LENALIDOMIDE) FOR THE TREATMENT OF PATIENTS WITH MULTIPLE MYELOMA, IN COMBINATION WITH DEXAMETHASONE
20MG REVLIMID CELGENE N021880 June 5, 2013 RX CAPSULE ORAL 8648095 May 15, 2023 USE OF REVLIMID (LENALIDOMIDE) FOR THE TREATMENT OF PATIENTS WITH MULTIPLE MYELOMA, IN COMBINATION WITH DEXAMETHASONE
20MG REVLIMID CELGENE N021880 June 5, 2013 RX CAPSULE ORAL 9101621 May 15, 2023 USE OF REVLIMID (LENALIDOMIDE) FOR THE TREATMENT OF PATIENTS WITH MULTIPLE MYELOMA, AS MAINTENANCE FOLLOWING AUTOLOGOUS HEMATOPOIETIC STEM CELL TRANSPLANTATION (AUTO-HSCT)
20MG REVLIMID CELGENE N021880 June 5, 2013 RX CAPSULE ORAL 9101622 May 15, 2023 USE OF REVLIMID (LENALIDOMIDE) FOR THE TREATMENT OF PATIENTS WITH MULTIPLE MYELOMA, IN COMBINATION WITH DEXAMETHASONE, WHEREIN THOSE PATIENTS HAVE NOT RECEIVED PREVIOUS TREATMENT FOR MULTIPLE MYELOMA
20MG REVLIMID CELGENE N021880 June 5, 2013 RX CAPSULE ORAL 9155730 May 15, 2023 USE OF REVLIMID (LENALIDOMIDE) FOR THE TREATMENT OF PREVIOUSLY TREATED FOLLICULAR LYMPHOMA IN COMBINATION WITH A RITUXIMAB PRODUCT
20MG REVLIMID CELGENE N021880 June 5, 2013 RX CAPSULE ORAL 9393238 May 15, 2023 USE OF REVLIMID (LENALIDOMIDE) FOR THE TREATMENT OF PREVIOUSLY TREATED FOLLICULAR LYMPHOMA IN COMBINATION WITH A RITUXIMAB PRODUCT
25MG REVLIMID CELGENE N021880 June 29, 2006 RX CAPSULE ORAL 8530498 May 15, 2023 USE OF REVLIMID (LENALIDOMIDE) FOR THE TREATMENT OF PATIENTS WITH MULTIPLE MYELOMA, IN COMBINATION WITH DEXAMETHASONE
25MG REVLIMID CELGENE N021880 June 29, 2006 RX CAPSULE ORAL 8648095 May 15, 2023 USE OF REVLIMID (LENALIDOMIDE) FOR THE TREATMENT OF PATIENTS WITH MULTIPLE MYELOMA, IN COMBINATION WITH DEXAMETHASONE
25MG REVLIMID CELGENE N021880 June 29, 2006 RX CAPSULE ORAL 9101621 May 15, 2023 USE OF REVLIMID (LENALIDOMIDE) FOR THE TREATMENT OF PATIENTS WITH MULTIPLE MYELOMA, AS MAINTENANCE FOLLOWING AUTOLOGOUS HEMATOPOIETIC STEM CELL TRANSPLANTATION (AUTO-HSCT)
25MG REVLIMID CELGENE N021880 June 29, 2006 RX CAPSULE ORAL 9101622 May 15, 2023 USE OF REVLIMID (LENALIDOMIDE) FOR THE TREATMENT OF PATIENTS WITH MULTIPLE MYELOMA, IN COMBINATION WITH DEXAMETHASONE, WHEREIN THOSE PATIENTS HAVE NOT RECEIVED PREVIOUS TREATMENT FOR MULTIPLE MYELOMA
25MG REVLIMID CELGENE N021880 June 29, 2006 RX CAPSULE ORAL 9155730 May 15, 2023 USE OF REVLIMID (LENALIDOMIDE) FOR THE TREATMENT OF PREVIOUSLY TREATED FOLLICULAR LYMPHOMA IN COMBINATION WITH A RITUXIMAB PRODUCT
25MG REVLIMID CELGENE N021880 June 29, 2006 RX CAPSULE ORAL 9393238 May 15, 2023 USE OF REVLIMID (LENALIDOMIDE) FOR THE TREATMENT OF PREVIOUSLY TREATED FOLLICULAR LYMPHOMA IN COMBINATION WITH A RITUXIMAB PRODUCT
5MG REVLIMID CELGENE N021880 Dec. 27, 2005 RX CAPSULE ORAL 8530498 May 15, 2023 USE OF REVLIMID (LENALIDOMIDE) FOR THE TREATMENT OF PATIENTS WITH MULTIPLE MYELOMA, IN COMBINATION WITH DEXAMETHASONE
5MG REVLIMID CELGENE N021880 Dec. 27, 2005 RX CAPSULE ORAL 8648095 May 15, 2023 USE OF REVLIMID (LENALIDOMIDE) FOR THE TREATMENT OF PATIENTS WITH MULTIPLE MYELOMA, IN COMBINATION WITH DEXAMETHASONE
5MG REVLIMID CELGENE N021880 Dec. 27, 2005 RX CAPSULE ORAL 9101621 May 15, 2023 USE OF REVLIMID (LENALIDOMIDE) FOR THE TREATMENT OF PATIENTS WITH MULTIPLE MYELOMA, AS MAINTENANCE FOLLOWING AUTOLOGOUS HEMATOPOIETIC STEM CELL TRANSPLANTATION (AUTO-HSCT)
5MG REVLIMID CELGENE N021880 Dec. 27, 2005 RX CAPSULE ORAL 9101622 May 15, 2023 USE OF REVLIMID (LENALIDOMIDE) FOR THE TREATMENT OF PATIENTS WITH MULTIPLE MYELOMA, IN COMBINATION WITH DEXAMETHASONE, WHEREIN THOSE PATIENTS HAVE NOT RECEIVED PREVIOUS TREATMENT FOR MULTIPLE MYELOMA
5MG REVLIMID CELGENE N021880 Dec. 27, 2005 RX CAPSULE ORAL 9155730 May 15, 2023 USE OF REVLIMID (LENALIDOMIDE) FOR THE TREATMENT OF PREVIOUSLY TREATED FOLLICULAR LYMPHOMA IN COMBINATION WITH A RITUXIMAB PRODUCT
5MG REVLIMID CELGENE N021880 Dec. 27, 2005 RX CAPSULE ORAL 9393238 May 15, 2023 USE OF REVLIMID (LENALIDOMIDE) FOR THE TREATMENT OF PREVIOUSLY TREATED FOLLICULAR LYMPHOMA IN COMBINATION WITH A RITUXIMAB PRODUCT
10MG REVLIMID CELGENE N021880 Dec. 27, 2005 RX CAPSULE ORAL 7468363 Oct. 7, 2023 USE OF REVLIMID (LENALIDOMIDE) FOR THE TREATMENT OF PATIENTS WITH MANTLE CELL LYMPHOMA WHOSE DISEASE HAS RELAPSED OR PROGRESSED AFTER TWO PRIOR THERAPIES, ONE OF WHICH INCLUDED BORTEZOMIB
10MG REVLIMID CELGENE N021880 Dec. 27, 2005 RX CAPSULE ORAL 7468363 Oct. 7, 2023 USE OF REVLIMID (LENALIDOMIDE) FOR THE TREATMENT OF PREVIOUSLY TREATED FOLLICULAR LYMPHOMA IN COMBINATION WITH A RITUXIMAB PRODUCT
10MG REVLIMID CELGENE N021880 Dec. 27, 2005 RX CAPSULE ORAL 7468363 Oct. 7, 2023 USE OF REVLIMID (LENALIDOMIDE) FOR THE TREATMENT OF PREVIOUSLY TREATED MARGINAL ZONE LYMPHOMA IN COMBINATION WITH A RITUXIMAB PRODUCT
10MG REVLIMID CELGENE N021880 Dec. 27, 2005 RX CAPSULE ORAL 7968569 Oct. 7, 2023 USE OF REVLIMID (LENALIDOMIDE) FOR THE TREATMENT OF PATIENTS WITH MULTIPLE MYELOMA, IN COMBINATION WITH DEXAMETHASONE
10MG REVLIMID CELGENE N021880 Dec. 27, 2005 RX CAPSULE ORAL 8492406 Oct. 7, 2023 USE OF REVLIMID (LENALIDOMIDE) FOR THE TREATMENT OF PREVIOUSLY TREATED FOLLICULAR LYMPHOMA IN COMBINATION WITH A RITUXIMAB PRODUCT
15MG REVLIMID CELGENE N021880 June 29, 2006 RX CAPSULE ORAL 7468363 Oct. 7, 2023 USE OF REVLIMID (LENALIDOMIDE) FOR THE TREATMENT OF PATIENTS WITH MANTLE CELL LYMPHOMA WHOSE DISEASE HAS RELAPSED OR PROGRESSED AFTER TWO PRIOR THERAPIES, ONE OF WHICH INCLUDED BORTEZOMIB
15MG REVLIMID CELGENE N021880 June 29, 2006 RX CAPSULE ORAL 7468363 Oct. 7, 2023 USE OF REVLIMID (LENALIDOMIDE) FOR THE TREATMENT OF PREVIOUSLY TREATED FOLLICULAR LYMPHOMA IN COMBINATION WITH A RITUXIMAB PRODUCT
15MG REVLIMID CELGENE N021880 June 29, 2006 RX CAPSULE ORAL 7468363 Oct. 7, 2023 USE OF REVLIMID (LENALIDOMIDE) FOR THE TREATMENT OF PREVIOUSLY TREATED MARGINAL ZONE LYMPHOMA IN COMBINATION WITH A RITUXIMAB PRODUCT
15MG REVLIMID CELGENE N021880 June 29, 2006 RX CAPSULE ORAL 7968569 Oct. 7, 2023 USE OF REVLIMID (LENALIDOMIDE) FOR THE TREATMENT OF PATIENTS WITH MULTIPLE MYELOMA, IN COMBINATION WITH DEXAMETHASONE
15MG REVLIMID CELGENE N021880 June 29, 2006 RX CAPSULE ORAL 8492406 Oct. 7, 2023 USE OF REVLIMID (LENALIDOMIDE) FOR THE TREATMENT OF PREVIOUSLY TREATED FOLLICULAR LYMPHOMA IN COMBINATION WITH A RITUXIMAB PRODUCT
2.5MG REVLIMID CELGENE N021880 Dec. 21, 2011 RX CAPSULE ORAL 7468363 Oct. 7, 2023 USE OF REVLIMID (LENALIDOMIDE) FOR THE TREATMENT OF PATIENTS WITH MANTLE CELL LYMPHOMA WHOSE DISEASE HAS RELAPSED OR PROGRESSED AFTER TWO PRIOR THERAPIES, ONE OF WHICH INCLUDED BORTEZOMIB
2.5MG REVLIMID CELGENE N021880 Dec. 21, 2011 RX CAPSULE ORAL 7468363 Oct. 7, 2023 USE OF REVLIMID (LENALIDOMIDE) FOR THE TREATMENT OF PREVIOUSLY TREATED FOLLICULAR LYMPHOMA IN COMBINATION WITH A RITUXIMAB PRODUCT
2.5MG REVLIMID CELGENE N021880 Dec. 21, 2011 RX CAPSULE ORAL 7468363 Oct. 7, 2023 USE OF REVLIMID (LENALIDOMIDE) FOR THE TREATMENT OF PREVIOUSLY TREATED MARGINAL ZONE LYMPHOMA IN COMBINATION WITH A RITUXIMAB PRODUCT
2.5MG REVLIMID CELGENE N021880 Dec. 21, 2011 RX CAPSULE ORAL 7968569 Oct. 7, 2023 USE OF REVLIMID (LENALIDOMIDE) FOR THE TREATMENT OF PATIENTS WITH MULTIPLE MYELOMA, IN COMBINATION WITH DEXAMETHASONE
2.5MG REVLIMID CELGENE N021880 Dec. 21, 2011 RX CAPSULE ORAL 8492406 Oct. 7, 2023 USE OF REVLIMID (LENALIDOMIDE) FOR THE TREATMENT OF PREVIOUSLY TREATED FOLLICULAR LYMPHOMA IN COMBINATION WITH A RITUXIMAB PRODUCT
20MG REVLIMID CELGENE N021880 June 5, 2013 RX CAPSULE ORAL 7468363 Oct. 7, 2023 USE OF REVLIMID (LENALIDOMIDE) FOR THE TREATMENT OF PATIENTS WITH MANTLE CELL LYMPHOMA WHOSE DISEASE HAS RELAPSED OR PROGRESSED AFTER TWO PRIOR THERAPIES, ONE OF WHICH INCLUDED BORTEZOMIB
20MG REVLIMID CELGENE N021880 June 5, 2013 RX CAPSULE ORAL 7468363 Oct. 7, 2023 USE OF REVLIMID (LENALIDOMIDE) FOR THE TREATMENT OF PREVIOUSLY TREATED FOLLICULAR LYMPHOMA IN COMBINATION WITH A RITUXIMAB PRODUCT
20MG REVLIMID CELGENE N021880 June 5, 2013 RX CAPSULE ORAL 7468363 Oct. 7, 2023 USE OF REVLIMID (LENALIDOMIDE) FOR THE TREATMENT OF PREVIOUSLY TREATED MARGINAL ZONE LYMPHOMA IN COMBINATION WITH A RITUXIMAB PRODUCT
20MG REVLIMID CELGENE N021880 June 5, 2013 RX CAPSULE ORAL 7968569 Oct. 7, 2023 USE OF REVLIMID (LENALIDOMIDE) FOR THE TREATMENT OF PATIENTS WITH MULTIPLE MYELOMA, IN COMBINATION WITH DEXAMETHASONE
20MG REVLIMID CELGENE N021880 June 5, 2013 RX CAPSULE ORAL 8492406 Oct. 7, 2023 USE OF REVLIMID (LENALIDOMIDE) FOR THE TREATMENT OF PREVIOUSLY TREATED FOLLICULAR LYMPHOMA IN COMBINATION WITH A RITUXIMAB PRODUCT
25MG REVLIMID CELGENE N021880 June 29, 2006 RX CAPSULE ORAL 7468363 Oct. 7, 2023 USE OF REVLIMID (LENALIDOMIDE) FOR THE TREATMENT OF PATIENTS WITH MANTLE CELL LYMPHOMA WHOSE DISEASE HAS RELAPSED OR PROGRESSED AFTER TWO PRIOR THERAPIES, ONE OF WHICH INCLUDED BORTEZOMIB
25MG REVLIMID CELGENE N021880 June 29, 2006 RX CAPSULE ORAL 7468363 Oct. 7, 2023 USE OF REVLIMID (LENALIDOMIDE) FOR THE TREATMENT OF PREVIOUSLY TREATED FOLLICULAR LYMPHOMA IN COMBINATION WITH A RITUXIMAB PRODUCT
25MG REVLIMID CELGENE N021880 June 29, 2006 RX CAPSULE ORAL 7468363 Oct. 7, 2023 USE OF REVLIMID (LENALIDOMIDE) FOR THE TREATMENT OF PREVIOUSLY TREATED MARGINAL ZONE LYMPHOMA IN COMBINATION WITH A RITUXIMAB PRODUCT
25MG REVLIMID CELGENE N021880 June 29, 2006 RX CAPSULE ORAL 7968569 Oct. 7, 2023 USE OF REVLIMID (LENALIDOMIDE) FOR THE TREATMENT OF PATIENTS WITH MULTIPLE MYELOMA, IN COMBINATION WITH DEXAMETHASONE
25MG REVLIMID CELGENE N021880 June 29, 2006 RX CAPSULE ORAL 8492406 Oct. 7, 2023 USE OF REVLIMID (LENALIDOMIDE) FOR THE TREATMENT OF PREVIOUSLY TREATED FOLLICULAR LYMPHOMA IN COMBINATION WITH A RITUXIMAB PRODUCT
5MG REVLIMID CELGENE N021880 Dec. 27, 2005 RX CAPSULE ORAL 7468363 Oct. 7, 2023 USE OF REVLIMID (LENALIDOMIDE) FOR THE TREATMENT OF PATIENTS WITH MANTLE CELL LYMPHOMA WHOSE DISEASE HAS RELAPSED OR PROGRESSED AFTER TWO PRIOR THERAPIES, ONE OF WHICH INCLUDED BORTEZOMIB
5MG REVLIMID CELGENE N021880 Dec. 27, 2005 RX CAPSULE ORAL 7468363 Oct. 7, 2023 USE OF REVLIMID (LENALIDOMIDE) FOR THE TREATMENT OF PREVIOUSLY TREATED FOLLICULAR LYMPHOMA IN COMBINATION WITH A RITUXIMAB PRODUCT
5MG REVLIMID CELGENE N021880 Dec. 27, 2005 RX CAPSULE ORAL 7468363 Oct. 7, 2023 USE OF REVLIMID (LENALIDOMIDE) FOR THE TREATMENT OF PREVIOUSLY TREATED MARGINAL ZONE LYMPHOMA IN COMBINATION WITH A RITUXIMAB PRODUCT
5MG REVLIMID CELGENE N021880 Dec. 27, 2005 RX CAPSULE ORAL 7968569 Oct. 7, 2023 USE OF REVLIMID (LENALIDOMIDE) FOR THE TREATMENT OF PATIENTS WITH MULTIPLE MYELOMA, IN COMBINATION WITH DEXAMETHASONE
5MG REVLIMID CELGENE N021880 Dec. 27, 2005 RX CAPSULE ORAL 8492406 Oct. 7, 2023 USE OF REVLIMID (LENALIDOMIDE) FOR THE TREATMENT OF PREVIOUSLY TREATED FOLLICULAR LYMPHOMA IN COMBINATION WITH A RITUXIMAB PRODUCT
10MG REVLIMID CELGENE N021880 Dec. 27, 2005 RX CAPSULE ORAL 8741929 March 8, 2028 USE OF REVLIMID (LENALIDOMIDE) FOR THE TREATMENT OF PATIENTS WITH MANTLE CELL LYMPHOMA WHOSE DISEASE HAS RELAPSED OR PROGRESSED AFTER TWO PRIOR THERAPIES, ONE OF WHICH INCLUDED BORTEZOMIB
15MG REVLIMID CELGENE N021880 June 29, 2006 RX CAPSULE ORAL 8741929 March 8, 2028 USE OF REVLIMID (LENALIDOMIDE) FOR THE TREATMENT OF PATIENTS WITH MANTLE CELL LYMPHOMA WHOSE DISEASE HAS RELAPSED OR PROGRESSED AFTER TWO PRIOR THERAPIES, ONE OF WHICH INCLUDED BORTEZOMIB
2.5MG REVLIMID CELGENE N021880 Dec. 21, 2011 RX CAPSULE ORAL 8741929 March 8, 2028 USE OF REVLIMID (LENALIDOMIDE) FOR THE TREATMENT OF PATIENTS WITH MANTLE CELL LYMPHOMA WHOSE DISEASE HAS RELAPSED OR PROGRESSED AFTER TWO PRIOR THERAPIES, ONE OF WHICH INCLUDED BORTEZOMIB
20MG REVLIMID CELGENE N021880 June 5, 2013 RX CAPSULE ORAL 8741929 March 8, 2028 USE OF REVLIMID (LENALIDOMIDE) FOR THE TREATMENT OF PATIENTS WITH MANTLE CELL LYMPHOMA WHOSE DISEASE HAS RELAPSED OR PROGRESSED AFTER TWO PRIOR THERAPIES, ONE OF WHICH INCLUDED BORTEZOMIB
25MG REVLIMID CELGENE N021880 June 29, 2006 RX CAPSULE ORAL 8741929 March 8, 2028 USE OF REVLIMID (LENALIDOMIDE) FOR THE TREATMENT OF PATIENTS WITH MANTLE CELL LYMPHOMA WHOSE DISEASE HAS RELAPSED OR PROGRESSED AFTER TWO PRIOR THERAPIES, ONE OF WHICH INCLUDED BORTEZOMIB
5MG REVLIMID CELGENE N021880 Dec. 27, 2005 RX CAPSULE ORAL 8741929 March 8, 2028 USE OF REVLIMID (LENALIDOMIDE) FOR THE TREATMENT OF PATIENTS WITH MANTLE CELL LYMPHOMA WHOSE DISEASE HAS RELAPSED OR PROGRESSED AFTER TWO PRIOR THERAPIES, ONE OF WHICH INCLUDED BORTEZOMIB

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
2.5MG LENALIDOMIDE DR REDDYS A209348 Oct. 14, 2021 RX CAPSULE ORAL March 6, 2023 PATENT CHALLENGE
20MG LENALIDOMIDE DR REDDYS A209348 Oct. 14, 2021 RX CAPSULE ORAL March 6, 2023 PATENT CHALLENGE
10MG REVLIMID CELGENE N021880 Dec. 27, 2005 RX CAPSULE ORAL Feb. 22, 2024 TREATMENT OF MULTIPLE MYELOMA (MM), AS MAINTENANCE FOLLOWING AUTOLOGOUS HEMATOPOIETIC STEM CELL TRANSPLANTATION (AUTO-HSCT)
15MG REVLIMID CELGENE N021880 June 29, 2006 RX CAPSULE ORAL Feb. 22, 2024 TREATMENT OF MULTIPLE MYELOMA (MM), AS MAINTENANCE FOLLOWING AUTOLOGOUS HEMATOPOIETIC STEM CELL TRANSPLANTATION (AUTO-HSCT)
2.5MG REVLIMID CELGENE N021880 Dec. 21, 2011 RX CAPSULE ORAL Feb. 22, 2024 TREATMENT OF MULTIPLE MYELOMA (MM), AS MAINTENANCE FOLLOWING AUTOLOGOUS HEMATOPOIETIC STEM CELL TRANSPLANTATION (AUTO-HSCT)
20MG REVLIMID CELGENE N021880 June 5, 2013 RX CAPSULE ORAL Feb. 22, 2024 TREATMENT OF MULTIPLE MYELOMA (MM), AS MAINTENANCE FOLLOWING AUTOLOGOUS HEMATOPOIETIC STEM CELL TRANSPLANTATION (AUTO-HSCT)
25MG REVLIMID CELGENE N021880 June 29, 2006 RX CAPSULE ORAL Feb. 22, 2024 TREATMENT OF MULTIPLE MYELOMA (MM), AS MAINTENANCE FOLLOWING AUTOLOGOUS HEMATOPOIETIC STEM CELL TRANSPLANTATION (AUTO-HSCT)
5MG REVLIMID CELGENE N021880 Dec. 27, 2005 RX CAPSULE ORAL Feb. 22, 2024 TREATMENT OF MULTIPLE MYELOMA (MM), AS MAINTENANCE FOLLOWING AUTOLOGOUS HEMATOPOIETIC STEM CELL TRANSPLANTATION (AUTO-HSCT)
10MG REVLIMID CELGENE N021880 Dec. 27, 2005 RX CAPSULE ORAL May 28, 2026 INDICATED IN COMBINATION WITH A RITUXIMAB PRODUCT FOR THE TREATMENT OF ADULT PATIENTS WITH PREVIOUSLY TREATED FOLLICULAR LYMPHOMA (FL)
10MG REVLIMID CELGENE N021880 Dec. 27, 2005 RX CAPSULE ORAL May 28, 2026 INDICATED IN COMBINATION WITH A RITUXIMAB PRODUCT FOR THE TREATMENT OF ADULT PATIENTS WITH PREVIOUSLY TREATED MARGINAL ZONE LYMPHOMA (MZL)
15MG REVLIMID CELGENE N021880 June 29, 2006 RX CAPSULE ORAL May 28, 2026 INDICATED IN COMBINATION WITH A RITUXIMAB PRODUCT FOR THE TREATMENT OF ADULT PATIENTS WITH PREVIOUSLY TREATED FOLLICULAR LYMPHOMA (FL)
15MG REVLIMID CELGENE N021880 June 29, 2006 RX CAPSULE ORAL May 28, 2026 INDICATED IN COMBINATION WITH A RITUXIMAB PRODUCT FOR THE TREATMENT OF ADULT PATIENTS WITH PREVIOUSLY TREATED MARGINAL ZONE LYMPHOMA (MZL)
2.5MG REVLIMID CELGENE N021880 Dec. 21, 2011 RX CAPSULE ORAL May 28, 2026 INDICATED IN COMBINATION WITH A RITUXIMAB PRODUCT FOR THE TREATMENT OF ADULT PATIENTS WITH PREVIOUSLY TREATED FOLLICULAR LYMPHOMA (FL)
2.5MG REVLIMID CELGENE N021880 Dec. 21, 2011 RX CAPSULE ORAL May 28, 2026 INDICATED IN COMBINATION WITH A RITUXIMAB PRODUCT FOR THE TREATMENT OF ADULT PATIENTS WITH PREVIOUSLY TREATED MARGINAL ZONE LYMPHOMA (MZL)
20MG REVLIMID CELGENE N021880 June 5, 2013 RX CAPSULE ORAL May 28, 2026 INDICATED IN COMBINATION WITH A RITUXIMAB PRODUCT FOR THE TREATMENT OF ADULT PATIENTS WITH PREVIOUSLY TREATED FOLLICULAR LYMPHOMA (FL)
20MG REVLIMID CELGENE N021880 June 5, 2013 RX CAPSULE ORAL May 28, 2026 INDICATED IN COMBINATION WITH A RITUXIMAB PRODUCT FOR THE TREATMENT OF ADULT PATIENTS WITH PREVIOUSLY TREATED MARGINAL ZONE LYMPHOMA (MZL)
25MG REVLIMID CELGENE N021880 June 29, 2006 RX CAPSULE ORAL May 28, 2026 INDICATED IN COMBINATION WITH A RITUXIMAB PRODUCT FOR THE TREATMENT OF ADULT PATIENTS WITH PREVIOUSLY TREATED FOLLICULAR LYMPHOMA (FL)
25MG REVLIMID CELGENE N021880 June 29, 2006 RX CAPSULE ORAL May 28, 2026 INDICATED IN COMBINATION WITH A RITUXIMAB PRODUCT FOR THE TREATMENT OF ADULT PATIENTS WITH PREVIOUSLY TREATED MARGINAL ZONE LYMPHOMA (MZL)
5MG REVLIMID CELGENE N021880 Dec. 27, 2005 RX CAPSULE ORAL May 28, 2026 INDICATED IN COMBINATION WITH A RITUXIMAB PRODUCT FOR THE TREATMENT OF ADULT PATIENTS WITH PREVIOUSLY TREATED FOLLICULAR LYMPHOMA (FL)
5MG REVLIMID CELGENE N021880 Dec. 27, 2005 RX CAPSULE ORAL May 28, 2026 INDICATED IN COMBINATION WITH A RITUXIMAB PRODUCT FOR THE TREATMENT OF ADULT PATIENTS WITH PREVIOUSLY TREATED MARGINAL ZONE LYMPHOMA (MZL)

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Protein cereblon Cytosolic other MODULATOR EC50 6.53 SCIENTIFIC LITERATURE SCIENTIFIC LITERATURE
Tumor necrosis factor Cytokine IC50 7.89 WOMBAT-PK
Bromodomain-containing protein 4 Unclassified IC50 5.29 CHEMBL
Cereblon isoform 4 Unclassified Ki 5.51 CHEMBL

External reference:

IDSource
4025089 VUID
N0000175347 NUI
D04687 KEGG_DRUG
4025089 VANDF
C1144149 UMLSCUI
CHEBI:63791 CHEBI
CHEMBL848 ChEMBL_ID
DB00480 DRUGBANK_ID
D000077269 MESH_DESCRIPTOR_UI
216326 PUBCHEM_CID
7331 IUPHAR_LIGAND_ID
8505 INN_ID
F0P408N6V4 UNII
337535 RXNORM
20816 MMSL
355195 MMSL
73707 MMSL
d05696 MMSL
011171 NDDF
421471009 SNOMEDCT_US
421737001 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Lenalidomide HUMAN PRESCRIPTION DRUG LABEL 1 0378-1935 CAPSULE 2.50 mg ORAL ANDA 33 sections
Lenalidomide HUMAN PRESCRIPTION DRUG LABEL 1 0378-1936 CAPSULE 5 mg ORAL ANDA 33 sections
Lenalidomide HUMAN PRESCRIPTION DRUG LABEL 1 0378-1936 CAPSULE 5 mg ORAL ANDA 33 sections
Lenalidomide HUMAN PRESCRIPTION DRUG LABEL 1 0378-1937 CAPSULE 10 mg ORAL ANDA 33 sections
Lenalidomide HUMAN PRESCRIPTION DRUG LABEL 1 0378-1937 CAPSULE 10 mg ORAL ANDA 33 sections
Lenalidomide HUMAN PRESCRIPTION DRUG LABEL 1 0378-1940 CAPSULE 25 mg ORAL ANDA 33 sections
Lenalidomide HUMAN PRESCRIPTION DRUG LABEL 1 0378-1940 CAPSULE 25 mg ORAL ANDA 33 sections
Lenalidomide HUMAN PRESCRIPTION DRUG LABEL 1 0378-1941 CAPSULE 15 mg ORAL ANDA 33 sections
Lenalidomide HUMAN PRESCRIPTION DRUG LABEL 1 0378-1941 CAPSULE 15 mg ORAL ANDA 33 sections
Lenalidomide HUMAN PRESCRIPTION DRUG LABEL 1 0378-1942 CAPSULE 20 mg ORAL ANDA 33 sections
Lenalidomide HUMAN PRESCRIPTION DRUG LABEL 1 0480-1241 CAPSULE 2.50 mg ORAL ANDA 31 sections
Lenalidomide HUMAN PRESCRIPTION DRUG LABEL 1 0480-1242 CAPSULE 5 mg ORAL ANDA 31 sections
Lenalidomide HUMAN PRESCRIPTION DRUG LABEL 1 0480-1242 CAPSULE 5 mg ORAL ANDA 31 sections
Lenalidomide HUMAN PRESCRIPTION DRUG LABEL 1 0480-1243 CAPSULE 10 mg ORAL ANDA 31 sections
Lenalidomide HUMAN PRESCRIPTION DRUG LABEL 1 0480-1243 CAPSULE 10 mg ORAL ANDA 31 sections
Lenalidomide HUMAN PRESCRIPTION DRUG LABEL 1 0480-1244 CAPSULE 15 mg ORAL ANDA 31 sections
Lenalidomide HUMAN PRESCRIPTION DRUG LABEL 1 0480-1244 CAPSULE 15 mg ORAL ANDA 31 sections
Lenalidomide HUMAN PRESCRIPTION DRUG LABEL 1 0480-1245 CAPSULE 20 mg ORAL ANDA 31 sections
Lenalidomide HUMAN PRESCRIPTION DRUG LABEL 1 0480-1246 CAPSULE 25 mg ORAL ANDA 31 sections
Lenalidomide HUMAN PRESCRIPTION DRUG LABEL 1 0480-1246 CAPSULE 25 mg ORAL ANDA 31 sections
LENALIDOMIDE HUMAN PRESCRIPTION DRUG LABEL 1 31722-257 CAPSULE 2.50 mg ORAL ANDA 29 sections
LENALIDOMIDE HUMAN PRESCRIPTION DRUG LABEL 1 31722-258 CAPSULE 5 mg ORAL ANDA 29 sections
LENALIDOMIDE HUMAN PRESCRIPTION DRUG LABEL 1 31722-259 CAPSULE 10 mg ORAL ANDA 29 sections
LENALIDOMIDE HUMAN PRESCRIPTION DRUG LABEL 1 31722-260 CAPSULE 15 mg ORAL ANDA 29 sections
LENALIDOMIDE HUMAN PRESCRIPTION DRUG LABEL 1 31722-261 CAPSULE 20 mg ORAL ANDA 29 sections
LENALIDOMIDE HUMAN PRESCRIPTION DRUG LABEL 1 31722-262 CAPSULE 25 mg ORAL ANDA 29 sections
Lenalidomide HUMAN PRESCRIPTION DRUG LABEL 1 43598-511 CAPSULE 5 mg ORAL ANDA 28 sections
Lenalidomide HUMAN PRESCRIPTION DRUG LABEL 1 43598-511 CAPSULE 5 mg ORAL ANDA 28 sections
Lenalidomide HUMAN PRESCRIPTION DRUG LABEL 1 43598-512 CAPSULE 10 mg ORAL ANDA 28 sections
Lenalidomide HUMAN PRESCRIPTION DRUG LABEL 1 43598-512 CAPSULE 10 mg ORAL ANDA 28 sections