colecalciferol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
Vitamin D analogues/derivatives 2840 67-97-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • Vitamin D3
  • cholecalciferol
  • arachitol
  • calciol
  • calcirol
  • colecalciferol
Derivative of 7-dehydroxycholesterol formed by ULTRAVIOLET RAYS breaking of the C9-C10 bond. It differs from ERGOCALCIFEROL in having a single bond between C22 and C23 and lacking a methyl group at C24. Some experts recommend maintaining recommended levels of vitamin D intake during the COVID-19 pandemic to maintain bone and muscle health and avoid deficiency. Efficacy of vitamin D supplementation in the prevention or treatment of COVID-19 has not been established.
  • Molecular weight: 384.65
  • Formula: C27H44O
  • CLOGP: 9.48
  • LIPINSKI: 1
  • HAC: 1
  • HDO: 1
  • TPSA: 20.23
  • ALOGS: -6.01
  • ROTB: 6
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
20 mcg O
10 mg O
5 mg O
10 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.10 mg/mL Benet LZ, Broccatelli F, Oprea TI

Approvals:

DateAgencyCompanyOrphan
May 18, 2000 FDA SANDOZ

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 1301.93 10.74 118 729794 133715 55428440
Toxicity to various agents 1179.30 10.74 727 729185 223837 55338318
Pemphigus 659.38 10.74 3882 726030 153330 55408825
Systemic lupus erythematosus 612.58 10.74 4216 725696 175862 55386293
Drug abuse 570.97 10.74 95 729817 67515 55494640
Death 562.32 10.74 2397 727515 339029 55223126
Glossodynia 541.43 10.74 3608 726304 148850 55413305
Intentional overdose 504.54 10.74 130 729782 67987 55494168
Alopecia 486.68 10.74 5879 724033 287579 55274576
Rheumatoid arthritis 481.01 10.74 7291 722621 375313 55186842
Abdominal discomfort 446.29 10.74 5524 724388 271750 55290405
Arthropathy 418.87 10.74 4202 725710 196073 55366082
Drug interaction 417.79 10.74 1361 728551 208394 55353761
Hand deformity 393.93 10.74 3039 726873 131453 55430702
Overdose 378.18 10.74 490 729422 105340 55456815
Wound 360.70 10.74 3052 726860 135752 55426403
Suicide attempt 339.92 10.74 162 729750 57674 55504481
Drug hypersensitivity 318.44 10.74 2174 727738 273031 55289124
Maternal exposure during pregnancy 308.71 10.74 3786 726126 185767 55376388
Cardiac arrest 307.99 10.74 400 729512 85914 55476241
Depressed level of consciousness 299.50 10.74 180 729732 56253 55505902
Pain 290.33 10.74 10913 718999 652271 54909884
Femur fracture 271.12 10.74 1119 728793 38176 55523979
Febrile neutropenia 256.44 10.74 622 729290 104923 55457232
Joint swelling 250.00 10.74 5205 724707 284595 55277560
Pericarditis 234.98 10.74 2301 727611 106622 55455533
Fatigue 231.31 10.74 12458 717454 776094 54786061
Arthralgia 229.35 10.74 8298 721614 493371 55068784
Anti-cyclic citrullinated peptide antibody positive 225.59 10.74 2109 727803 96491 55465664
Discomfort 222.71 10.74 2813 727099 138948 55423207
Cardio-respiratory arrest 212.52 10.74 242 729670 55079 55507076
Infusion related reaction 201.25 10.74 3816 726096 205115 55357040
Malignant neoplasm progression 196.37 10.74 412 729500 73175 55488980
Swelling 191.99 10.74 4261 725651 235510 55326645
Hypotension 190.18 10.74 2204 727708 248304 55313851
Synovitis 189.35 10.74 3041 726871 158264 55403891
Coma 185.76 10.74 304 729608 59351 55502804
Sedation 181.00 10.74 114 729798 34740 55527415
Respiratory arrest 176.56 10.74 88 729824 30537 55531618
Acute kidney injury 176.31 10.74 2135 727777 238628 55323527
Device expulsion 173.29 10.74 89 729823 30360 55531795
Contraindicated product administered 162.40 10.74 3352 726560 182934 55379221
Product use issue 160.68 10.74 3343 726569 182698 55379457
Osteoarthritis 153.92 10.74 1656 728256 78640 55483515
Hepatic function abnormal 144.13 10.74 141 729771 34417 55527738
Cardiac failure 141.76 10.74 565 729347 81528 55480627
Low turnover osteopathy 140.87 10.74 214 729698 3794 55558361
Lactic acidosis 137.52 10.74 153 729759 35193 55526962
Drug reaction with eosinophilia and systemic symptoms 136.69 10.74 115 729797 30189 55531966
Renal failure 136.61 10.74 855 729057 109645 55452510
Agitation 133.88 10.74 333 729579 55703 55506452
Serotonin syndrome 132.99 10.74 90 729822 26400 55535755
Nasopharyngitis 131.26 10.74 3773 726139 217186 55344969
Duodenal ulcer perforation 128.44 10.74 1404 728508 66938 55495217
Intentional self-injury 128.05 10.74 83 729829 24909 55537246
Drug resistance 127.82 10.74 53 729859 20489 55541666
Neutropenia 127.65 10.74 1372 728540 156795 55405360
Multiple organ dysfunction syndrome 127.32 10.74 312 729600 52458 55509697
Helicobacter infection 125.87 10.74 1479 728433 71789 55490366
Rheumatoid factor positive 122.17 10.74 1402 728510 67658 55494497
Musculoskeletal stiffness 120.19 10.74 2758 727154 153249 55408906
Metabolic acidosis 119.65 10.74 213 729699 40241 55521914
Disease progression 119.31 10.74 835 729077 104338 55457817
Knee arthroplasty 114.17 10.74 972 728940 43287 55518868
Somnolence 112.81 10.74 1467 728445 161946 55400209
Bradycardia 112.53 10.74 471 729441 67033 55495122
Hip arthroplasty 105.91 10.74 860 729052 37763 55524392
Anaphylactic reaction 105.06 10.74 401 729511 58594 55503561
Hepatic failure 104.84 10.74 170 729742 33316 55528839
Intramedullary rod insertion 104.48 10.74 131 729781 1920 55560235
Rhabdomyolysis 104.00 10.74 233 729679 40425 55521730
Psoriatic arthropathy 103.00 10.74 1437 728475 72571 55489584
Vitamin D deficiency 102.28 10.74 369 729543 11801 55550354
Myocardial infarction 100.65 10.74 747 729165 92123 55470032
Sinusitis 100.29 10.74 3310 726602 194271 55367884
Seizure 99.46 10.74 1089 728823 124030 55438125
Impaired healing 97.64 10.74 1626 728286 85215 55476940
Cardiac failure congestive 95.33 10.74 705 729207 87015 55475140
Hepatic enzyme increased 95.05 10.74 2902 727010 168482 55393673
Cytomegalovirus infection 93.64 10.74 68 729844 19228 55542927
Respiratory failure 93.11 10.74 786 729126 94276 55467879
Sedation complication 92.93 10.74 19 729893 11653 55550502
Peripheral swelling 92.19 10.74 3821 726091 230905 55331250
Drug dependence 91.60 10.74 94 729818 22439 55539716
Mydriasis 90.29 10.74 17 729895 11054 55551101
Dyspnoea 90.26 10.74 6542 723370 586035 54976120
Thrombocytopenia 89.97 10.74 1234 728678 134990 55427165
Osteoporosis 89.06 10.74 1050 728862 51002 55511153
Shock 87.92 10.74 91 729821 21637 55540518
Poisoning 86.53 10.74 29 729883 12784 55549371
Tachycardia 84.34 10.74 921 728991 104955 55457200
Electrocardiogram QT prolonged 84.24 10.74 392 729520 54196 55507959
Altered state of consciousness 83.82 10.74 105 729807 22916 55539239
Creatinine renal clearance decreased 80.71 10.74 44 729868 14515 55547640
Red blood cell sedimentation rate abnormal 80.61 10.74 465 729447 18208 55543947
Vomiting 77.30 10.74 5491 724421 492737 55069418
Product quality issue 75.48 10.74 189 729723 31547 55530608
Emotional distress 74.15 10.74 173 729739 29590 55532565
Drug withdrawal syndrome 73.92 10.74 139 729773 25718 55536437
Respiratory depression 72.79 10.74 35 729877 12400 55549755
Mental status changes 72.67 10.74 246 729666 37255 55524900
Tooth disorder 72.24 10.74 573 729339 24980 55537175
Hepatotoxicity 72.19 10.74 188 729724 30965 55531190
Acute hepatic failure 71.04 10.74 66 729846 16512 55545643
Sickle cell anaemia with crisis 70.05 10.74 182 729730 4846 55557309
Hypoglycaemia 69.40 10.74 431 729481 55384 55506771
No adverse event 68.87 10.74 241 729671 36133 55526022
International normalised ratio increased 67.52 10.74 317 729595 43724 55518431
Myelosuppression 67.41 10.74 76 729836 17379 55544776
Palmar-plantar erythrodysaesthesia syndrome 66.83 10.74 106 729806 20959 55541196
Hyperkalaemia 66.81 10.74 386 729526 50479 55511676
Foot fracture 66.64 10.74 498 729414 21311 55540844
Orthostatic hypotension 66.24 10.74 215 729697 32984 55529171
Pain in extremity 66.23 10.74 4591 725321 292840 55269315
Neuroleptic malignant syndrome 66.13 10.74 33 729879 11445 55550710
Spinal osteoarthritis 65.72 10.74 372 729540 14464 55547691
Encephalopathy 65.58 10.74 236 729676 35089 55527066
Open reduction of fracture 65.36 10.74 77 729835 1054 55561101
Asthma 65.28 10.74 1048 728864 111722 55450433
Unresponsive to stimuli 65.02 10.74 203 729709 31522 55530633
Sopor 63.83 10.74 108 729804 20814 55541341
Ejection fraction decreased 62.79 10.74 100 729812 19741 55542414
Loss of consciousness 61.71 10.74 1021 728891 108328 55453827
Syncope 61.48 10.74 1009 728903 107190 55454965
Aspartate aminotransferase increased 61.29 10.74 730 729182 81872 55480283
Blood creatine phosphokinase increased 60.78 10.74 174 729738 27778 55534377
Extrapyramidal disorder 60.67 10.74 43 729869 12313 55549842
Blood cholesterol increased 60.54 10.74 1298 728614 71281 55490874
Accidental exposure to product 59.23 10.74 146 729766 24501 55537654
Arthritis 59.17 10.74 1705 728207 98147 55464008
Disseminated intravascular coagulation 58.65 10.74 88 729824 17797 55544358
Infective pulmonary exacerbation of cystic fibrosis 58.39 10.74 235 729677 7922 55554233
Fracture nonunion 58.14 10.74 104 729808 2123 55560032
Ventricular fibrillation 58.00 10.74 35 729877 10917 55551238
Fracture delayed union 57.77 10.74 107 729805 2246 55559909
Anaphylactic shock 57.73 10.74 122 729790 21618 55540537
Ventricular tachycardia 57.54 10.74 81 729831 16820 55545335
Drug ineffective for unapproved indication 57.30 10.74 158 729754 25535 55536620
Alanine aminotransferase increased 56.37 10.74 864 729048 92798 55469357
Torsade de pointes 56.36 10.74 47 729865 12393 55549762
Psychotic disorder 56.26 10.74 140 729772 23418 55538737
Hypoxia 54.87 10.74 441 729471 53456 55508699
Posterior reversible encephalopathy syndrome 54.83 10.74 76 729836 15884 55546271
Product use in unapproved indication 54.20 10.74 1400 728512 139422 55422733
Foot deformity 54.12 10.74 509 729403 23316 55538839
Rheumatic fever 53.58 10.74 591 729321 28236 55533919
Unintentional medical device removal 52.77 10.74 6 729906 5688 55556467
Sepsis 52.30 10.74 1396 728516 138444 55423711
Coagulopathy 52.28 10.74 102 729810 18614 55543541
Brain oedema 52.11 10.74 57 729855 13214 55548941
Pulmonary arterial hypertension 51.94 10.74 173 729739 26330 55535825
Cardiogenic shock 51.93 10.74 82 729830 16243 55545912
Intentional product misuse 51.70 10.74 423 729489 51081 55511074
Ascites 51.43 10.74 281 729631 37263 55524892
Status epilepticus 51.12 10.74 73 729839 15068 55547087
Basal cell carcinoma 51.04 10.74 526 729386 24695 55537460
Blood alkaline phosphatase increased 50.90 10.74 296 729616 38649 55523506
Intervertebral disc degeneration 50.27 10.74 337 729575 13917 55548238
Lower respiratory tract infection 49.72 10.74 1889 728023 112905 55449250
Hyponatraemia 49.64 10.74 979 728933 101160 55460995
Spinal fracture 49.60 10.74 374 729538 16050 55546105
Nausea 49.32 10.74 8943 720969 755235 54806920
Swollen joint count increased 49.24 10.74 505 729407 23679 55538476
Pulmonary oedema 49.10 10.74 425 729487 50718 55511437
Septic shock 48.91 10.74 528 729384 60307 55501848
Acute respiratory distress syndrome 48.78 10.74 135 729777 21791 55540364
Joint effusion 48.27 10.74 345 729567 14553 55547602
Akathisia 48.18 10.74 26 729886 8626 55553529
Stevens-Johnson syndrome 47.88 10.74 143 729769 22520 55539635
Stress fracture 47.62 10.74 202 729710 6975 55555180
Renal impairment 47.40 10.74 748 729164 79965 55482190
Pulmonary embolism 47.29 10.74 1043 728869 106081 55456074
Body height decreased 47.28 10.74 240 729672 8945 55553210
Thrombotic microangiopathy 47.20 10.74 32 729880 9379 55552776
Bone marrow failure 46.73 10.74 198 729714 28088 55534067
Fall 46.60 10.74 5306 724606 352204 55209951
Cognitive disorder 46.41 10.74 410 729502 48723 55513432
Hyperhidrosis 46.28 10.74 900 729012 93188 55468967
Anaemia 46.09 10.74 2920 726992 264591 55297564
Metastases to liver 45.75 10.74 136 729776 21450 55540705
Transplant rejection 45.66 10.74 37 729875 9897 55552258
Venoocclusive liver disease 45.48 10.74 3 729909 4418 55557737
Anaemia postoperative 45.40 10.74 92 729820 2069 55560086
Injection site reaction 45.28 10.74 955 728957 52292 55509863
Therapeutic product effect decreased 45.21 10.74 2657 727255 166795 55395360
Angioedema 45.09 10.74 333 729579 41120 55521035
Psoriasis 44.96 10.74 1545 728367 91147 55471008
Tremor 44.70 10.74 1211 728701 119878 55442277
Product complaint 44.55 10.74 52 729860 11708 55550447
Exposure during pregnancy 44.38 10.74 2178 727734 134164 55427991
Gastrointestinal haemorrhage 44.22 10.74 705 729207 75246 55486909
Injection site pruritus 44.16 10.74 777 729135 41154 55521001
Suicidal ideation 44.10 10.74 507 729405 57235 55504920
Wrong technique in product usage process 43.94 10.74 512 729400 57656 55504499
Dystonia 43.83 10.74 58 729854 12363 55549792
Off label use 43.82 10.74 8017 721895 548163 55013992
Device difficult to use 43.62 10.74 45 729867 10716 55551439
Acute myeloid leukaemia 43.61 10.74 97 729815 16875 55545280
Thoracic vertebral fracture 43.54 10.74 138 729774 4125 55558030
Blood bilirubin increased 43.33 10.74 254 729658 33100 55529055
Device use error 43.19 10.74 9 729903 5447 55556708
Hepatocellular injury 42.94 10.74 187 729725 26327 55535828
Accidental overdose 42.58 10.74 130 729782 20331 55541824
Pyrexia 42.54 10.74 4767 725145 414006 55148149
Night sweats 42.45 10.74 761 729151 40452 55521703
Pleural effusion 42.24 10.74 817 729095 84663 55477492
Anhedonia 41.86 10.74 40 729872 9874 55552281
Obstructive airways disorder 41.82 10.74 102 729810 17180 55544975
Neurotoxicity 41.64 10.74 89 729823 15706 55546449
Acute generalised exanthematous pustulosis 41.46 10.74 40 729872 9829 55552326
Graft versus host disease 41.38 10.74 18 729894 6763 55555392
Toxic skin eruption 41.23 10.74 55 729857 11684 55550471
Tooth fracture 41.21 10.74 251 729661 10025 55552130
Hypomania 41.12 10.74 7 729905 4895 55557260
Vitamin D decreased 41.06 10.74 229 729683 8854 55553301
Hypokalaemia 40.96 10.74 922 728990 93515 55468640
Cerebral infarction 40.69 10.74 152 729760 22353 55539802
Osteopenia 40.42 10.74 386 729526 17755 55544400
Blood pressure decreased 40.37 10.74 531 729381 58519 55503636
Delirium 40.07 10.74 355 729557 42162 55519993
Platelet count decreased 40.03 10.74 1061 728851 105322 55456833
Acute graft versus host disease 39.72 10.74 4 729908 4171 55557984
Aggression 39.54 10.74 149 729763 21857 55540298
Metastases to central nervous system 39.52 10.74 60 729852 12076 55550079
Bone loss 39.26 10.74 105 729807 2846 55559309
Disorientation 38.93 10.74 296 729616 36317 55525838
Restlessness 38.64 10.74 195 729717 26391 55535764
Hyperglycaemia 38.60 10.74 314 729598 37967 55524188
Face oedema 38.57 10.74 117 729795 18335 55543820
Bone density decreased 38.21 10.74 290 729622 12470 55549685
Device dislocation 38.11 10.74 157 729755 22449 55539706
Abnormal behaviour 37.91 10.74 135 729777 20137 55542018
Miosis 37.91 10.74 19 729893 6573 55555582
Cerebrovascular accident 37.89 10.74 988 728924 98282 55463873
Haematotoxicity 37.57 10.74 32 729880 8351 55553804
Fracture 37.52 10.74 378 729534 17640 55544515
Dysarthria 37.37 10.74 330 729582 39220 55522935
Myoclonus 37.36 10.74 89 729823 15114 55547041
Metastases to bone 37.10 10.74 129 729783 19379 55542776
Deep vein thrombosis 37.04 10.74 739 729173 76238 55485917
Cholecystitis chronic 37.04 10.74 43 729869 9705 55552450
Substance abuse 36.79 10.74 7 729905 4518 55557637
Bronchospasm 36.73 10.74 94 729818 15575 55546580
Contusion 36.61 10.74 2026 727886 126404 55435751
Leukopenia 36.60 10.74 673 729239 70267 55491888
Scoliosis 36.28 10.74 182 729730 6751 55555404
Gamma-glutamyltransferase increased 36.20 10.74 244 729668 30761 55531394
Neutrophil count decreased 35.92 10.74 443 729469 49379 55512776
Asphyxia 35.91 10.74 15 729897 5774 55556381
Multiple fractures 35.83 10.74 189 729723 7152 55555003
Blood glucose increased 35.41 10.74 724 729188 74427 55487728
Interstitial lung disease 35.14 10.74 524 729388 56539 55505616
Lower respiratory tract infection viral 34.67 10.74 48 729864 779 55561376
Respiratory distress 34.63 10.74 254 729658 31413 55530742
Atypical femur fracture 34.23 10.74 143 729769 4904 55557251
Toxic epidermal necrolysis 34.17 10.74 158 729754 21884 55540271
Pregnancy 34.03 10.74 610 729302 32423 55529732
Sleep disorder due to general medical condition, insomnia type 33.89 10.74 768 729144 42570 55519585
Anxiety 33.86 10.74 2105 727807 191067 55371088
Hallucination, auditory 33.78 10.74 61 729851 11463 55550692
Haemodialysis 33.62 10.74 37 729875 8554 55553601
Pancreatitis 33.58 10.74 398 729514 44682 55517473
Injection site erythema 33.42 10.74 1274 728638 76174 55485981
Muscle spasticity 33.41 10.74 401 729511 19559 55542596
Bronchopulmonary aspergillosis 33.00 10.74 35 729877 8229 55553926
Renal injury 32.91 10.74 40 729872 8847 55553308
Weight increased 32.62 10.74 3429 726483 226274 55335881
Synovial cyst 32.59 10.74 218 729694 8996 55553159
Cyanosis 32.51 10.74 101 729811 15709 55546446
Urinary tract infection 32.29 10.74 3577 726335 236936 55325219
Hypothermia 32.26 10.74 71 729841 12399 55549756
Cardiotoxicity 32.14 10.74 31 729881 7619 55554536
Cerebral haemorrhage 31.98 10.74 228 729684 28378 55533777
Inappropriate antidiuretic hormone secretion 31.88 10.74 83 729829 13673 55548482
Injection site swelling 31.54 10.74 764 729148 42814 55519341
Carpal tunnel syndrome 31.46 10.74 367 729545 17777 55544378
Schizophrenia 31.29 10.74 55 729857 10444 55551711
Jaundice 31.27 10.74 216 729696 27078 55535077
Anuria 31.22 10.74 66 729846 11694 55550461
Tonsillar ulcer 31.08 10.74 28 729884 273 55561882
Genital haemorrhage 30.99 10.74 26 729886 6836 55555319
Tardive dyskinesia 30.98 10.74 35 729877 7996 55554159
COVID-19 30.81 10.74 1228 728684 73830 55488325
Sinus tachycardia 30.73 10.74 168 729744 22276 55539879
Dysmorphism 30.72 10.74 80 729832 2133 55560022
Multiple sclerosis relapse 30.64 10.74 781 729131 44122 55518033
Pathogen resistance 30.63 10.74 20 729892 5980 55556175
Ear pain 30.27 10.74 566 729346 30324 55531831
Disability assessment scale score increased 30.04 10.74 91 729821 2653 55559502
Product dose omission issue 29.98 10.74 3063 726849 201690 55360465
Muscle injury 29.87 10.74 892 729020 51608 55510547
Neck deformity 29.74 10.74 75 729837 1960 55560195
Schizoaffective disorder 29.69 10.74 95 729817 2854 55559301
Pulmonary hypertension 29.68 10.74 310 729602 35634 55526521
Myopathy 29.61 10.74 51 729861 9761 55552394
Coronary artery disease 29.52 10.74 256 729656 30540 55531615
Mania 29.47 10.74 66 729846 11454 55550701
Erythema multiforme 29.44 10.74 49 729863 9505 55552650
Hypersensitivity 29.34 10.74 3775 726137 252633 55309522
Blood pressure fluctuation 29.33 10.74 708 729204 39652 55522503
Agranulocytosis 29.19 10.74 173 729739 22486 55539669
Plasma cell myeloma 29.19 10.74 427 729485 46219 55515936
Haemorrhage 29.10 10.74 535 729377 55862 55506293
Oropharyngeal pain 29.06 10.74 1347 728565 82441 55479714
Breast cancer stage I 28.89 10.74 23 729889 6207 55555948
Haemophagocytic lymphohistiocytosis 28.66 10.74 50 729862 9522 55552633
Dehydration 28.65 10.74 1726 728186 157099 55405056
Multiple-drug resistance 28.63 10.74 8 729904 3966 55558189
Back pain 28.45 10.74 3502 726410 233668 55328487
Lethargy 28.45 10.74 482 729430 50959 55511196
Rash 28.37 10.74 7002 722910 486045 55076110
Irritable bowel syndrome 28.09 10.74 1120 728792 67338 55494817
Cardiomyopathy 27.98 10.74 112 729800 16146 55546009
Wrist fracture 27.85 10.74 258 729654 11768 55550387
Uterine perforation 27.75 10.74 26 729886 6479 55555676
Dental implantation 27.70 10.74 38 729874 611 55561544
Metastases to lung 27.70 10.74 70 729842 11648 55550507
Exostosis 27.60 10.74 306 729606 14637 55547518
Abortion spontaneous 27.55 10.74 753 729159 43000 55519155
Bone density abnormal 27.54 10.74 99 729813 3160 55558995
Graft versus host disease in gastrointestinal tract 27.48 10.74 3 729909 2936 55559219
Mucosal inflammation 27.45 10.74 390 729522 42420 55519735
Rash maculo-papular 27.40 10.74 241 729671 28666 55533489
Bone disorder 27.39 10.74 380 729532 19163 55542992
Aspergillus infection 27.23 10.74 34 729878 7431 55554724
C-reactive protein abnormal 27.14 10.74 647 729265 36162 55525993
Dental caries 27.11 10.74 225 729687 9943 55552212
Temperature regulation disorder 27.04 10.74 12 729900 4456 55557699
Blood creatinine increased 27.04 10.74 812 729100 79379 55482776
Joint laxity 26.81 10.74 81 729831 2358 55559797
Fear 26.75 10.74 101 729811 14807 55547348
Pulseless electrical activity 26.67 10.74 31 729881 6993 55555162
Chronic graft versus host disease 26.55 10.74 5 729907 3251 55558904
BK virus infection 26.55 10.74 4 729908 3060 55559095
Drug abuser 26.53 10.74 3 729909 2856 55559299
Cytokine release syndrome 26.46 10.74 64 729848 10811 55551344
Stress cardiomyopathy 26.39 10.74 42 729870 8294 55553861
Medical device removal 26.33 10.74 52 729860 1147 55561008
Cytomegalovirus viraemia 26.23 10.74 17 729895 5103 55557052
Live birth 26.19 10.74 378 729534 19227 55542928
Malignant melanoma 25.86 10.74 232 729680 10487 55551668
Pregnancy with contraceptive device 25.86 10.74 11 729901 4188 55557967
Folliculitis 25.80 10.74 913 728999 54066 55508089
Recalled product 25.57 10.74 56 729856 1332 55560823
Removal of internal fixation 25.43 10.74 15 729897 69 55562086
Left ventricular dysfunction 25.10 10.74 68 729844 11055 55551100
Abortion incomplete 25.08 10.74 5 729907 3122 55559033
Musculoskeletal pain 25.08 10.74 1290 728622 79862 55482293
Toxic encephalopathy 25.02 10.74 24 729888 5914 55556241
Febrile bone marrow aplasia 24.96 10.74 29 729883 6543 55555612
Drug screen positive 24.91 10.74 7 729905 3457 55558698
Confusional state 24.82 10.74 2342 727570 205813 55356342
Respiratory acidosis 24.72 10.74 26 729886 6137 55556018
Laryngitis 24.71 10.74 283 729629 13647 55548508
Gestational diabetes 24.56 10.74 184 729728 7880 55554275
Angina pectoris 24.46 10.74 238 729674 27738 55534417
Lumbar vertebral fracture 24.36 10.74 128 729784 4836 55557319
Cholestasis 24.36 10.74 227 729685 26686 55535469
Transplant dysfunction 23.99 10.74 16 729896 4730 55557425
Bradypnoea 23.92 10.74 6 729906 3197 55558958
Drug ineffective 23.40 10.74 11183 718729 907806 54654349
Polyarthritis 23.20 10.74 193 729719 8535 55553620
Drug intolerance 23.14 10.74 3839 726073 260979 55301176
Eosinophilia 22.94 10.74 159 729753 19918 55542237
Bone giant cell tumour 22.84 10.74 14 729898 70 55562085
Proteinuria 22.71 10.74 134 729778 17436 55544719
Hallucination 22.70 10.74 475 729437 48674 55513481
Speech disorder 22.50 10.74 346 729566 37147 55525008
Gastrointestinal toxicity 22.49 10.74 28 729884 6128 55556027
Skin cancer 22.42 10.74 219 729693 10136 55552019
Epstein-Barr virus infection 22.33 10.74 39 729873 7424 55554731
Fluid retention 22.31 10.74 532 729380 53546 55508609
Tumour lysis syndrome 22.29 10.74 43 729869 7880 55554275
Tendonitis 22.25 10.74 344 729568 17753 55544402
Exposure to toxic agent 22.07 10.74 10 729902 3668 55558487
Developmental hip dysplasia 22.03 10.74 51 729861 1260 55560895
Blister 21.82 10.74 1667 728245 107220 55454935
Melaena 21.75 10.74 248 729664 28042 55534113
Personality disorder 21.69 10.74 21 729891 5152 55557003
Dermatitis exfoliative 21.66 10.74 22 729890 5277 55556878
Ketoacidosis 21.61 10.74 13 729899 4062 55558093
Periprosthetic fracture 21.46 10.74 28 729884 428 55561727
Ileus paralytic 21.40 10.74 14 729898 4181 55557974
Hyperbilirubinaemia 21.32 10.74 65 729847 10170 55551985
Diabetes mellitus inadequate control 21.20 10.74 101 729811 13879 55548276
Acute coronary syndrome 21.09 10.74 61 729851 9707 55552448
Red blood cell count decreased 21.06 10.74 623 729289 35994 55526161
Fibromyalgia 21.05 10.74 960 728952 58643 55503512
Muscle strain 21.02 10.74 168 729744 7340 55554815
Intentional product use issue 21.02 10.74 1533 728379 98200 55463955
Anti-neutrophil cytoplasmic antibody positive vasculitis 20.99 10.74 4 729908 2579 55559576
Maternal exposure before pregnancy 20.96 10.74 156 729756 6667 55555488
Talipes 20.92 10.74 53 729859 1389 55560766
Dyskinesia 20.91 10.74 259 729653 28849 55533306
Influenza 20.89 10.74 1469 728443 93792 55468363
Hypercalciuria 20.88 10.74 22 729890 264 55561891
Myocarditis 20.87 10.74 53 729859 8805 55553350
Drug use disorder 20.71 10.74 18 729894 4651 55557504
Bronchitis 20.64 10.74 1708 728204 110603 55451552
Dry eye 20.63 10.74 608 729304 35108 55527047
Localised infection 20.57 10.74 483 729429 26929 55535226
Rebound effect 20.54 10.74 102 729810 3768 55558387
Catatonia 20.53 10.74 13 729899 3951 55558204
Blood calcium decreased 20.45 10.74 203 729709 23566 55538589
Hyperprolactinaemia 20.39 10.74 11 729901 3650 55558505
Lumbar spinal stenosis 20.32 10.74 112 729800 4311 55557844
Prescribed underdose 20.28 10.74 378 729534 20239 55541916
Gastroenteritis viral 20.28 10.74 375 729537 20049 55542106
Breast cancer stage II 20.20 10.74 27 729885 5731 55556424
Acute myocardial infarction 20.15 10.74 275 729637 30118 55532037
Muscle rigidity 20.00 10.74 71 729841 10600 55551555
Electrocardiogram QRS complex prolonged 19.83 10.74 25 729887 5442 55556713
Endodontic procedure 19.76 10.74 83 729829 2853 55559302
Chest discomfort 19.69 10.74 1064 728848 97793 55464362
Disease recurrence 19.61 10.74 206 729706 23654 55538501
Colorectal cancer 19.54 10.74 10 729902 3419 55558736
Joint dislocation 19.46 10.74 300 729612 15473 55546682
Bradyphrenia 19.44 10.74 35 729877 6585 55555570
Systemic infection 19.41 10.74 89 729823 3180 55558975
Bone metabolism disorder 19.39 10.74 24 729888 347 55561808
Complication associated with device 19.35 10.74 118 729794 15232 55546923
Rash erythematous 19.23 10.74 353 729559 36868 55525287
Hyperthermia 19.19 10.74 50 729862 8235 55553920
Gait spastic 18.92 10.74 20 729892 241 55561914
Hypercholesterolaemia 18.92 10.74 278 729634 14195 55547960
Neutropenic colitis 18.89 10.74 6 729906 2737 55559418
Tibia fracture 18.88 10.74 115 729797 4593 55557562
Neurologic neglect syndrome 18.75 10.74 3 729909 2195 55559960
Haemodynamic instability 18.74 10.74 51 729861 8278 55553877
Pulmonary congestion 18.72 10.74 127 729785 15988 55546167
Purpura 18.72 10.74 70 729842 10292 55551863
Caesarean section 18.70 10.74 303 729609 15788 55546367
Tenderness 18.62 10.74 366 729546 19789 55542366
Metastases to lymph nodes 18.61 10.74 43 729869 7380 55554775
Prothrombin time prolonged 18.54 10.74 58 729854 9002 55553153
Product substitution issue 18.52 10.74 112 729800 14487 55547668
Peripheral sensory neuropathy 18.50 10.74 39 729873 6917 55555238
Paranoia 18.50 10.74 74 729838 10670 55551485
Breast cancer metastatic 18.43 10.74 121 729791 15348 55546807
Nightmare 18.38 10.74 135 729777 16691 55545464
Tonsillectomy 18.37 10.74 35 729877 751 55561404
Chest pain 18.37 10.74 2167 727745 187630 55374525
Skin papilloma 18.22 10.74 110 729802 4379 55557776
Urticaria 18.21 10.74 1621 728291 143055 55419100
Hypomagnesaemia 18.19 10.74 222 729690 24793 55537362
Condition aggravated 18.17 10.74 4880 725032 340018 55222137
Leukocytosis 18.12 10.74 209 729703 23582 55538573
Joint destruction 18.12 10.74 120 729792 4935 55557220
Grip strength decreased 18.11 10.74 304 729608 15952 55546203
Chronic kidney disease 18.11 10.74 411 729501 41645 55520510
Right ventricular failure 18.09 10.74 131 729781 16248 55545907
Arrhythmia 18.04 10.74 333 729579 34750 55527405
Generalised oedema 18.01 10.74 112 729800 14389 55547766
Small for dates baby 18 10.74 92 729820 3438 55558717
Adenovirus infection 17.89 10.74 11 729901 3397 55558758
Ileus 17.88 10.74 106 729806 13776 55548379
General physical health deterioration 17.80 10.74 2490 727422 167520 55394635
Gingival disorder 17.80 10.74 88 729824 3245 55558910
Treatment failure 17.77 10.74 2495 727417 167897 55394258
Irritability 17.77 10.74 273 729639 29315 55532840
Spondylolisthesis 17.72 10.74 88 729824 3251 55558904
Catheter site erythema 17.68 10.74 16 729896 4054 55558101
Diabetic ketoacidosis 17.59 10.74 158 729754 18713 55543442
Angina unstable 17.51 10.74 39 729873 6782 55555373
Increased tendency to bruise 17.50 10.74 199 729713 9579 55552576
Hyperammonaemia 17.50 10.74 23 729889 4917 55557238
Smear cervix abnormal 17.48 10.74 77 729835 2704 55559451
Intraductal proliferative breast lesion 17.42 10.74 76 729836 2657 55559498
Rotator cuff syndrome 17.38 10.74 237 729675 11906 55550249
Acute respiratory failure 17.27 10.74 290 729622 30704 55531451
Pericardial effusion 17.27 10.74 248 729664 26927 55535228
Osteoporotic fracture 17.25 10.74 87 729825 3234 55558921
Atrioventricular block 17.18 10.74 40 729872 6847 55555308
Abdominal pain 17.15 10.74 3023 726889 255782 55306373
Intervertebral disc protrusion 17.13 10.74 385 729527 21309 55540846
Pulmonary alveolar haemorrhage 17.09 10.74 18 729894 4246 55557909
Latent tuberculosis 17.05 10.74 71 729841 2431 55559724
Limb reduction defect 17.04 10.74 23 729889 364 55561791
Visual acuity reduced 17.01 10.74 179 729733 20547 55541608
Heart rate increased 17.01 10.74 894 729018 82379 55479776
Flushing 17.00 10.74 739 729173 69361 55492794
Oral infection 16.87 10.74 108 729804 4390 55557765
Vitamin D increased 16.85 10.74 30 729882 610 55561545
Hallucination, visual 16.83 10.74 145 729767 17323 55544832
Atrioventricular block complete 16.77 10.74 46 729866 7448 55554707
Gastrooesophageal reflux disease 16.74 10.74 1275 728637 81982 55480173
Reversible cerebral vasoconstriction syndrome 16.73 10.74 5 729907 2372 55559783
Injection site rash 16.71 10.74 311 729601 16647 55545508
Endophthalmitis 16.71 10.74 10 729902 3133 55559022
Cardiac failure acute 16.65 10.74 59 729853 8814 55553341
Oedema 16.63 10.74 880 729032 81040 55481115
Toothache 16.62 10.74 325 729587 17555 55544600
Folate deficiency 16.62 10.74 64 729848 2113 55560042
Paradoxical drug reaction 16.61 10.74 15 729897 3805 55558350
Withdrawal syndrome 16.59 10.74 156 729756 18306 55543849
Rotator cuff repair 16.47 10.74 58 729854 1832 55560323
Pulmonary toxicity 16.46 10.74 50 729862 7833 55554322
Blood pressure diastolic abnormal 16.45 10.74 226 729686 11372 55550783
Colitis microscopic 16.41 10.74 50 729862 7825 55554330
Hypoaesthesia 16.40 10.74 2085 727827 139406 55422749
Pneumothorax 16.37 10.74 119 729793 14748 55547407
Hemiplegia 16.37 10.74 55 729857 8349 55553806
Cataract 16.31 10.74 817 729095 50430 55511725
Hallucinations, mixed 16.29 10.74 20 729892 4404 55557751
Parkinsonism 16.28 10.74 66 729846 9480 55552675
Forced expiratory volume decreased 16.20 10.74 22 729890 4638 55557517
Full blood count decreased 16.19 10.74 407 729505 22942 55539213
Plantar fasciitis 16.18 10.74 86 729826 3264 55558891
Hypophagia 16.15 10.74 270 729642 28606 55533549
Second primary malignancy 16.15 10.74 46 729866 7356 55554799
Skin toxicity 16.13 10.74 18 729894 4135 55558020
Hyperlipidaemia 16.11 10.74 327 729585 17782 55544373
Treatment noncompliance 16.05 10.74 312 729600 32311 55529844
Affect lability 16.04 10.74 72 729840 10053 55552102
Incorrect route of product administration 16.00 10.74 188 729724 21141 55541014
Humerus fracture 15.97 10.74 168 729744 7929 55554226
Spinal stenosis 15.96 10.74 263 729649 13751 55548404
Hypervolaemia 15.93 10.74 244 729668 26214 55535941
Fibula fracture 15.91 10.74 83 729829 3127 55559028
Acute lymphocytic leukaemia recurrent 15.86 10.74 5 729907 2292 55559863
Disability 15.76 10.74 290 729622 15490 55546665
Liver function test abnormal 15.76 10.74 461 729451 45210 55516945
Hepatic necrosis 15.71 10.74 28 729884 5288 55556867
Haemorrhage intracranial 15.59 10.74 99 729813 12656 55549499
Injury 15.56 10.74 626 729286 59225 55502930
Type 2 diabetes mellitus 15.52 10.74 750 729162 46112 55516043
Ear infection 15.51 10.74 523 729389 30772 55531383
Hepatitis B reactivation 15.50 10.74 6 729906 2418 55559737
Jaw disorder 15.49 10.74 116 729796 4967 55557188
Gait disturbance 15.43 10.74 2378 727534 160943 55401212
Bone graft 15.43 10.74 35 729877 853 55561302
Calcium deficiency 15.41 10.74 38 729874 979 55561176
Mouth ulceration 15.37 10.74 498 729414 29142 55533013
Circulatory collapse 15.36 10.74 184 729728 20619 55541536
Thyroid mass 15.35 10.74 93 729819 3707 55558448
Myocardial ischaemia 15.35 10.74 93 729819 12023 55550132
Joint stiffness 15.34 10.74 583 729329 34842 55527313
Tubulointerstitial nephritis 15.33 10.74 140 729772 16525 55545630
Ventricular septal defect 15.30 10.74 99 729813 4039 55558116
Carotid artery thrombosis 15.29 10.74 5 729907 2239 55559916
Injection site bruising 15.29 10.74 628 729284 37893 55524262
Graft versus host disease in skin 15.27 10.74 8 729904 2699 55559456
Nephropathy toxic 15.15 10.74 58 729854 8469 55553686
Surgery 15.12 10.74 539 729373 31947 55530208
Anger 15.10 10.74 89 729823 11583 55550572
Drug-induced liver injury 15.06 10.74 336 729576 34126 55528029
Metabolic disorder 15.05 10.74 30 729882 5431 55556724
Cystic fibrosis 15.02 10.74 86 729826 3358 55558797
Blood parathyroid hormone increased 15.02 10.74 76 729836 2829 55559326
Knee operation 15.01 10.74 119 729793 5186 55556969
Cyst 14.99 10.74 241 729671 12537 55549618
Eosinophil count increased 14.98 10.74 69 729843 9568 55552587
Blood pressure diastolic decreased 14.97 10.74 342 729570 18981 55543174
Musculoskeletal discomfort 14.97 10.74 296 729616 16022 55546133
Wrong product administered 14.92 10.74 32 729880 5640 55556515
Inadequate analgesia 14.91 10.74 8 729904 2663 55559492
Pulmonary haemorrhage 14.91 10.74 42 729870 6741 55555414
Hypoglycaemic coma 14.90 10.74 6 729906 2361 55559794
Blood pressure systolic abnormal 14.89 10.74 193 729719 9584 55552571
Weight decreased 14.86 10.74 3430 726482 237284 55324871
Abscess oral 14.85 10.74 48 729864 1450 55560705
Blood lactate dehydrogenase increased 14.84 10.74 184 729728 20491 55541664
Pulse absent 14.82 10.74 26 729886 4941 55557214
Dysphoria 14.76 10.74 25 729887 4817 55557338
Acidosis 14.71 10.74 78 729834 10423 55551732
Decreased appetite 14.70 10.74 2559 727353 216672 55345483
Joint noise 14.68 10.74 92 729820 3712 55558443
Cystitis 14.63 10.74 777 729135 48261 55513894
Juvenile idiopathic arthritis 14.59 10.74 109 729803 4664 55557491
Transaminases increased 14.50 10.74 274 729638 28496 55533659
Activated partial thromboplastin time prolonged 14.49 10.74 41 729871 6571 55555584
Breast cancer female 14.45 10.74 97 729815 12241 55549914
Lupus-like syndrome 14.44 10.74 234 729678 12193 55549962
Oral herpes 14.42 10.74 394 729518 22496 55539659
Disturbance in social behaviour 14.39 10.74 11 729901 3030 55559125
Systemic candida 14.39 10.74 11 729901 3030 55559125
Pseudomembranous colitis 14.39 10.74 10 729902 2893 55559262
Meniscus injury 14.34 10.74 139 729773 6419 55555736
Blood urea increased 14.29 10.74 227 729685 24246 55537909
Limb deformity 14.29 10.74 93 729819 3802 55558353
Oedema peripheral 14.27 10.74 1974 727938 169280 55392875
Hyperaesthesia teeth 14.23 10.74 50 729862 1578 55560577
Catheter site pain 14.20 10.74 21 729891 4272 55557883
Enterocolitis 14.17 10.74 46 729866 7058 55555097
Generalised tonic-clonic seizure 14.06 10.74 262 729650 27304 55534851
Ligament sprain 14.06 10.74 218 729694 11257 55550898
Cold type haemolytic anaemia 14.03 10.74 16 729896 211 55561944
Complication of device insertion 13.96 10.74 40 729872 6384 55555771
Tenosynovitis stenosans 13.94 10.74 69 729843 2545 55559610
Drug level increased 13.93 10.74 187 729725 20538 55541617
Cytopenia 13.92 10.74 72 729840 9683 55552472
Persecutory delusion 13.91 10.74 8 729904 2562 55559593
Hepatitis cholestatic 13.89 10.74 40 729872 6374 55555781
Eye infection 13.87 10.74 198 729714 10046 55552109
Breast disorder 13.84 10.74 64 729848 2295 55559860
Joint injury 13.82 10.74 433 729479 25221 55536934
International normalised ratio fluctuation 13.82 10.74 7 729905 2407 55559748
Dyspnoea exertional 13.79 10.74 574 729338 54115 55508040
Edentulous 13.77 10.74 17 729895 245 55561910
Loss of employment 13.77 10.74 4 729908 1933 55560222
Squamous cell carcinoma 13.77 10.74 164 729748 7984 55554171
Pancreatitis acute 13.70 10.74 236 729676 24888 55537267
Nephrogenic systemic fibrosis 13.66 10.74 23 729889 4442 55557713
Hungry bone syndrome 13.62 10.74 11 729901 91 55562064
Ankle fracture 13.55 10.74 293 729619 16110 55546045
Liver transplant 13.54 10.74 6 729906 2230 55559925
Ligament rupture 13.53 10.74 76 729836 2946 55559209
Lumbar radiculopathy 13.47 10.74 54 729858 1817 55560338
Medication error 13.46 10.74 432 729480 41903 55520252
Gastroenteritis astroviral 13.43 10.74 4 729908 0 55562155
Nodule 13.34 10.74 326 729586 18293 55543862
Spinal compression fracture 13.34 10.74 242 729670 12892 55549263
Dizziness 13.27 10.74 4523 725389 371617 55190538
Bursitis 13.18 10.74 459 729453 27123 55535032
Heart rate decreased 13.18 10.74 646 729266 39781 55522374
Acute graft versus host disease in intestine 13.17 10.74 3 729909 1707 55560448
Invasive ductal breast carcinoma 13.17 10.74 141 729771 6685 55555470
Blood pH decreased 13.16 10.74 8 729904 2486 55559669
Limb injury 13.10 10.74 380 729532 21890 55540265
Complication of device removal 13.06 10.74 24 729888 4480 55557675
Cyst removal 13.03 10.74 22 729890 428 55561727
Intestinal stenosis 13.02 10.74 68 729844 2563 55559592
Isosthenuria 12.99 10.74 11 729901 98 55562057
Device malfunction 12.98 10.74 140 729772 15996 55546159
Sciatica 12.97 10.74 435 729477 25575 55536580
Appendicectomy 12.95 10.74 69 729843 2621 55559534
Pupil fixed 12.95 10.74 3 729909 1687 55560468
Liver disorder 12.88 10.74 458 729454 43912 55518243
Polyhydramnios 12.87 10.74 58 729854 2057 55560098
Bone erosion 12.87 10.74 269 729643 14705 55547450
Cataract operation 12.85 10.74 106 729806 4676 55557479
Ischaemic stroke 12.81 10.74 148 729764 16694 55545461
Pneumonia 12.77 10.74 4917 724995 402181 55159974
Anaphylactoid reaction 12.75 10.74 16 729896 3490 55558665
Dermatitis acneiform 12.73 10.74 23 729889 4321 55557834
Milk-alkali syndrome 12.67 10.74 28 729884 670 55561485
Acute pulmonary oedema 12.66 10.74 53 729859 7544 55554611
Pharyngitis streptococcal 12.63 10.74 183 729729 9315 55552840
Accidental death 12.63 10.74 4 729908 1828 55560327
Kidney transplant rejection 12.62 10.74 22 729890 4191 55557964
Tonsillitis 12.60 10.74 113 729799 5107 55557048
Peripheral venous disease 12.55 10.74 192 729720 9887 55552268
Red blood cell sedimentation rate increased 12.53 10.74 588 729324 36035 55526120
Hernia 12.49 10.74 202 729710 10521 55551634
Amylase increased 12.49 10.74 36 729876 5735 55556420
Upper limb fracture 12.48 10.74 301 729611 16854 55545301
Biliary dyskinesia 12.48 10.74 9 729903 2554 55559601
Erythema 12.46 10.74 1802 728110 154137 55408018
Hysterectomy 12.43 10.74 168 729744 8423 55553732
Traumatic arthritis 12.42 10.74 7 729905 29 55562126
Biopsy breast 12.41 10.74 17 729895 273 55561882
Catheter management 12.41 10.74 11 729901 2815 55559340
Limb hypoplasia congenital 12.37 10.74 14 729898 183 55561972
Disturbance in attention 12.37 10.74 324 729588 32216 55529939
Osteochondrosis 12.34 10.74 38 729874 1118 55561037
Hepatitis fulminant 12.32 10.74 14 729898 3190 55558965
Patellofemoral pain syndrome 12.31 10.74 25 729887 563 55561592
Oral disorder 12.29 10.74 161 729751 8014 55554141
Maternal drugs affecting foetus 12.17 10.74 110 729802 4983 55557172
Seasonal allergy 12.10 10.74 299 729613 16809 55545346
Scapula fracture 12.07 10.74 21 729891 419 55561736
Essential hypertension 12.06 10.74 103 729809 4590 55557565
Dialysis 12.01 10.74 75 729837 9627 55552528
Stomatitis 11.99 10.74 1764 728148 119046 55443109
Blood iron increased 11.88 10.74 43 729869 1377 55560778
Onychomycosis 11.87 10.74 134 729778 6438 55555717
Wheezing 11.86 10.74 825 729087 74201 55487954
Clear cell renal cell carcinoma 11.86 10.74 40 729872 1236 55560919
Congenital arterial malformation 11.85 10.74 18 729894 319 55561836
Polyneuropathy 11.84 10.74 110 729802 12940 55549215
Knee deformity 11.79 10.74 36 729876 1054 55561101
Sexual dysfunction 11.77 10.74 16 729896 3372 55558783
Basosquamous carcinoma 11.76 10.74 5 729907 9 55562146
Periodontal disease 11.73 10.74 45 729867 1483 55560672
Device deployment issue 11.72 10.74 18 729894 3606 55558549
Rash morbilliform 11.71 10.74 13 729899 2994 55559161
Intracranial pressure increased 11.66 10.74 26 729886 4519 55557636
Oliguria 11.65 10.74 63 729849 8377 55553778
Alcohol interaction 11.61 10.74 8 729904 2325 55559830
Mitral valve prolapse 11.60 10.74 58 729854 2148 55560007
Blood lactic acid increased 11.60 10.74 40 729872 6024 55556131
Muscle spasms 11.59 10.74 1988 727924 135383 55426772
Dairy intolerance 11.58 10.74 9 729903 70 55562085
Neck mass 11.55 10.74 80 729832 3340 55558815
Type IIa hyperlipidaemia 11.54 10.74 11 729901 116 55562039
Unintended pregnancy 11.52 10.74 32 729880 5159 55556996
Potentiating drug interaction 11.50 10.74 22 729890 4044 55558111
Hyperparathyroidism 11.48 10.74 65 729847 2527 55559628
Hyperlactacidaemia 11.45 10.74 10 729902 2578 55559577
Loss of personal independence in daily activities 11.43 10.74 1214 728698 80155 55482000
Apraxia 11.42 10.74 4 729908 1715 55560440
Soft tissue disorder 11.39 10.74 24 729888 4258 55557897
Crush syndrome 11.39 10.74 11 729901 118 55562037
Enthesopathy 11.39 10.74 157 729755 7906 55554249
Amenorrhoea 11.37 10.74 69 729843 8917 55553238
Renal tubular necrosis 11.29 10.74 88 729824 10740 55551415
Periodontal operation 11.27 10.74 7 729905 36 55562119
Endovenous ablation 11.23 10.74 4 729908 3 55562152
Closed fracture manipulation 11.19 10.74 6 729906 22 55562133
Osteomalacia 11.18 10.74 27 729885 686 55561469
Cartilage injury 11.17 10.74 50 729862 1768 55560387
Acute myeloid leukaemia recurrent 11.15 10.74 3 729909 1525 55560630
Synovial disorder 11.15 10.74 36 729876 1087 55561068
Product monitoring error 11.15 10.74 80 729832 3379 55558776
Injection site pain 11.14 10.74 1706 728206 115412 55446743
Hypoalbuminaemia 11.12 10.74 86 729826 10513 55551642
Haemorrhage subcutaneous 11.11 10.74 12 729900 2798 55559357
Squamous cell carcinoma of skin 11.09 10.74 113 729799 5289 55556866
Breast feeding 11.06 10.74 30 729882 820 55561335
Hemiparesis 11.04 10.74 204 729708 21286 55540869
Drug eruption 11.03 10.74 252 729660 25511 55536644
Limb discomfort 11.02 10.74 436 729476 26186 55535969
Arthritis infective 11.02 10.74 122 729790 5834 55556321
Atrial septal defect 11.02 10.74 131 729781 6375 55555780
Exostosis of jaw 11.00 10.74 38 729874 1189 55560966
Haematochezia 10.98 10.74 682 729230 43036 55519119
Adverse event 10.96 10.74 847 729065 54529 55507626
Premature rupture of membranes 10.92 10.74 102 729810 4663 55557492
Facial paralysis 10.91 10.74 115 729797 13196 55548959
Groin pain 10.90 10.74 176 729736 9164 55552991
Gallbladder operation 10.90 10.74 55 729857 2045 55560110
Product dose omission in error 10.89 10.74 96 729816 4318 55557837
Clostridium difficile colitis 10.88 10.74 174 729738 18564 55543591
Floating patella 10.83 10.74 5 729907 12 55562143
Steroid therapy 10.82 10.74 9 729903 78 55562077
Congenital oral malformation 10.81 10.74 13 729899 182 55561973
Capillary leak syndrome 10.81 10.74 6 729906 1960 55560195
Ventricular hypokinesia 10.80 10.74 24 729888 4177 55557978
Diabetes mellitus 10.79 10.74 566 729346 52169 55509986
Nasal polyps 10.77 10.74 16 729896 3249 55558906
Tooth infection 10.75 10.74 274 729638 15478 55546677
Hepatic cytolysis 10.75 10.74 90 729822 10816 55551339

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Toxicity to various agents 527.89 10.72 460 268888 181027 31246969
Drug abuse 472.62 10.72 87 269261 87671 31340325
Completed suicide 436.07 10.72 119 269229 91395 31336601
Rheumatoid arthritis 228.99 10.72 908 268440 46901 31381095
Drug interaction 193.65 10.72 1013 268335 207530 31220466
Foetal exposure during pregnancy 174.19 10.72 749 268599 40127 31387869
Intentional overdose 172.11 10.72 68 269280 41321 31386675
Arthralgia 152.00 10.72 1959 267389 149465 31278531
Fatigue 143.39 10.72 3793 265555 331413 31096583
Hepatic function abnormal 128.85 10.72 97 269251 41125 31386871
Suicide attempt 117.26 10.72 87 269261 37161 31390835
Overdose 111.82 10.72 358 268990 84306 31343690
Infective pulmonary exacerbation of cystic fibrosis 107.86 10.72 196 269152 6288 31421708
Drug resistance 98.37 10.72 38 269310 23415 31404581
Psoriatic arthropathy 94.62 10.72 377 268971 19506 31408490
Acute kidney injury 86.95 10.72 1766 267582 277948 31150048
Death 86.46 10.72 2369 266979 358200 31069796
Dysmorphism 84.63 10.72 117 269231 2955 31425041
Multiple organ dysfunction syndrome 84.15 10.72 297 269051 67906 31360090
Coma 79.79 10.72 142 269206 41008 31386988
Renal failure 78.98 10.72 669 268679 122661 31305335
Drug reaction with eosinophilia and systemic symptoms 78.95 10.72 83 269265 29935 31398061
Fall 77.84 10.72 2101 267247 183988 31244008
Rhabdomyolysis 76.36 10.72 280 269068 63301 31364695
Cardiac arrest 75.68 10.72 445 268903 88617 31339379
Nasopharyngitis 74.55 10.72 844 268504 62401 31365595
Respiratory arrest 74.37 10.72 68 269280 26189 31401807
Sickle cell anaemia with crisis 73.11 10.72 106 269242 2801 31425195
Multiple sclerosis relapse 71.21 10.72 245 269103 11802 31416194
Peripheral swelling 70.90 10.72 885 268463 66980 31361016
Joint swelling 68.01 10.72 724 268624 52707 31375289
Blood pressure fluctuation 66.30 10.72 374 268974 22362 31405634
Speech disorder developmental 64.26 10.72 84 269264 2007 31425989
Product dose omission issue 63.29 10.72 1254 268094 104332 31323664
Febrile neutropenia 63.17 10.72 696 268652 121153 31306843
Cytomegalovirus infection 63.10 10.72 70 269278 24637 31403359
Basal cell carcinoma 61.15 10.72 311 269037 17868 31410128
Product use in unapproved indication 60.34 10.72 545 268803 98626 31329370
Serotonin syndrome 60.18 10.72 43 269305 18730 31409266
Vitamin D deficiency 57.58 10.72 144 269204 5788 31422208
Toxic epidermal necrolysis 55.96 10.72 50 269298 19474 31408522
Musculoskeletal stiffness 54.48 10.72 564 268784 40761 31387235
Pain 54.44 10.72 2019 267329 184740 31243256
Altered state of consciousness 51.21 10.72 62 269286 20989 31407007
Disseminated intravascular coagulation 50.48 10.72 60 269288 20477 31407519
Lactic acidosis 50.30 10.72 124 269224 31813 31396183
Depressed level of consciousness 49.69 10.72 165 269183 38436 31389560
Weight decreased 48.49 10.72 1737 267611 158215 31269781
Cardio-respiratory arrest 46.86 10.72 253 269095 51473 31376523
Poisoning 46.72 10.72 15 269333 10376 31417620
Pathogen resistance 45.99 10.72 9 269339 8692 31419304
Angioedema 45.86 10.72 140 269208 33478 31394518
Shock 44.93 10.72 77 269271 22568 31405428
Hepatic failure 44.74 10.72 136 269212 32566 31395430
Enthesopathy 44.73 10.72 107 269241 4180 31423816
Maternal exposure during pregnancy 43.08 10.72 111 269237 4545 31423451
Sinusitis 42.90 10.72 489 268859 36207 31391789
Sedation 42.89 10.72 59 269289 18906 31409090
Tenosynovitis 42.77 10.72 104 269244 4106 31423890
Drug withdrawal syndrome 41.73 10.72 59 269289 18691 31409305
Vitamin D decreased 41.36 10.72 85 269263 2992 31425004
Drug ineffective 41.20 10.72 2852 266496 392721 31035275
Cardiac failure 40.25 10.72 502 268846 85451 31342545
Cough 39.37 10.72 1458 267890 133356 31294640
Intentional product misuse 39.34 10.72 177 269171 37774 31390222
Foetal anticonvulsant syndrome 39.14 10.72 49 269299 1120 31426876
General physical health deterioration 38.16 10.72 1247 268101 112188 31315808
Osteoarthritis 37.44 10.72 284 269064 18783 31409213
Neonatal respiratory distress syndrome 37.38 10.72 94 269254 3791 31424205
Stevens-Johnson syndrome 37.35 10.72 56 269292 17316 31410680
Blood creatine phosphokinase increased 37.09 10.72 207 269141 41767 31386229
Atrial septal defect 36.77 10.72 136 269212 6791 31421205
Neuroleptic malignant syndrome 36.64 10.72 54 269294 16815 31411181
Substance abuse 36.60 10.72 8 269340 7150 31420846
Interstitial lung disease 36.22 10.72 340 269008 61063 31366933
Psoriasis 35.81 10.72 577 268771 46142 31381854
Arthritis 35.73 10.72 373 268975 27012 31400984
Premature baby 35.43 10.72 269 269079 17797 31410199
Hypoglycaemia neonatal 35.04 10.72 58 269290 1724 31426272
Disease progression 35 10.72 549 268799 89915 31338081
Hypospadias 34.94 10.72 80 269268 3036 31424960
Osteoporosis 34.73 10.72 192 269156 11391 31416605
Back pain 33.32 10.72 1189 268159 108224 31319772
Hypotension 33.03 10.72 1412 267936 203206 31224790
Cryptorchism 32.97 10.72 60 269288 1927 31426069
Post transplant lymphoproliferative disorder 32.72 10.72 6 269342 6070 31421926
Intentional self-injury 32.62 10.72 39 269309 13276 31414720
Relapsing-remitting multiple sclerosis 32.50 10.72 40 269308 898 31427098
Pain in extremity 32.30 10.72 1250 268098 114953 31313043
Suicidal ideation 31.91 10.72 180 269168 36226 31391770
Respiratory failure 31.82 10.72 639 268709 100810 31327186
Maternal exposure during breast feeding 31.24 10.72 51 269297 1498 31426498
Myocardial infarction 31.15 10.72 730 268618 112724 31315272
Autism spectrum disorder 31.13 10.72 62 269286 2133 31425863
Mucormycosis 31.10 10.72 5 269343 5565 31422431
Nephrolithiasis 30.91 10.72 362 268986 26977 31401019
Memory impairment 30.76 10.72 475 268873 37655 31390341
Small for dates baby 30.64 10.72 84 269264 3571 31424425
Neurotoxicity 30.54 10.72 57 269291 16169 31411827
Learning disorder 30.27 10.72 41 269307 1015 31426981
Syndactyly 30.15 10.72 37 269311 828 31427168
Acute hepatic failure 30.10 10.72 39 269309 12820 31415176
Exposure during pregnancy 29.55 10.72 148 269200 8450 31419546
Electrocardiogram QT prolonged 29.54 10.72 195 269153 37792 31390204
Acute graft versus host disease 29.27 10.72 8 269340 6145 31421851
Mean cell volume increased 29.23 10.72 71 269277 2801 31425195
Blood iron decreased 29.14 10.72 97 269251 4593 31423403
Wound 29.10 10.72 199 269149 12729 31415267
Acute respiratory distress syndrome 28.84 10.72 109 269239 24431 31403565
Maternal drugs affecting foetus 28.17 10.72 85 269263 3818 31424178
Palmar-plantar erythrodysaesthesia syndrome 27.74 10.72 56 269292 15427 31412569
Red blood cell count decreased 27.72 10.72 349 268999 26458 31401538
Psychotic disorder 27.53 10.72 97 269251 22196 31405800
Gait spastic 27.35 10.72 36 269312 866 31427130
Rash maculo-papular 27.23 10.72 119 269229 25600 31402396
Juvenile idiopathic arthritis 27.08 10.72 51 269297 1682 31426314
Bone giant cell tumour 27.00 10.72 13 269335 61 31427935
Aspergillus infection 26.94 10.72 35 269313 11493 31416503
Cystitis haemorrhagic 26.86 10.72 6 269342 5283 31422713
Poor venous access 26.80 10.72 86 269262 3994 31424002
Influenza 26.70 10.72 527 268821 43798 31384198
Cardiogenic shock 26.67 10.72 99 269249 22309 31405687
Agitation 26.62 10.72 313 269035 53856 31374140
Alanine aminotransferase abnormal 26.41 10.72 84 269264 3883 31424113
Balance disorder 26.40 10.72 456 268892 36966 31391030
Squamous cell carcinoma of skin 26.20 10.72 162 269186 10012 31417984
COVID-19 26.07 10.72 630 268718 54191 31373805
Neutropenia 26.00 10.72 953 268395 139411 31288585
Needle fatigue 25.94 10.72 32 269316 720 31427276
Immune reconstitution inflammatory syndrome 25.86 10.72 19 269329 8159 31419837
Joint laxity 25.75 10.72 24 269324 387 31427609
Vomiting 25.72 10.72 1600 267748 222373 31205623
Astigmatism 25.68 10.72 38 269310 1023 31426973
Colorectal cancer 25.51 10.72 5 269343 4824 31423172
Cataract 25.50 10.72 312 269036 23495 31404501
Upper respiratory tract infection 25.47 10.72 371 268977 29051 31398945
Somnolence 25.34 10.72 647 268701 98798 31329198
Attention deficit hyperactivity disorder 25.18 10.72 60 269288 2338 31425658
Skin cancer 25.16 10.72 151 269197 9234 31418762
Sopor 25.07 10.72 37 269311 11515 31416481
Venoocclusive liver disease 25.06 10.72 16 269332 7396 31420600
Foot deformity 25.06 10.72 85 269263 4064 31423932
Hyperkalaemia 25.06 10.72 390 268958 63961 31364035
Polydactyly 25.02 10.72 40 269308 1154 31426842
Red cell distribution width increased 25.02 10.72 102 269246 5332 31422664
Joint effusion 25.00 10.72 91 269257 4508 31423488
Arthropathy 24.81 10.72 313 269035 23738 31404258
Bronchopulmonary aspergillosis 24.70 10.72 49 269299 13585 31414411
Malignant neoplasm progression 24.64 10.72 498 268850 78500 31349496
Ventricular fibrillation 24.64 10.72 80 269268 18768 31409228
Suspected suicide 24.54 10.72 3 269345 4104 31423892
Ear infection 24.52 10.72 144 269204 8737 31419259
Hypoglycaemia 24.42 10.72 296 269052 50650 31377346
Foetal malformation 24.41 10.72 15 269333 123 31427873
Intellectual disability 24.16 10.72 40 269308 1189 31426807
Musculoskeletal pain 23.83 10.72 371 268977 29457 31398539
Folate deficiency 23.47 10.72 39 269309 1163 31426833
Hepatitis 23.42 10.72 102 269246 21964 31406032
Acute generalised exanthematous pustulosis 23.39 10.72 11 269337 6029 31421967
Brain oedema 23.35 10.72 46 269302 12786 31415210
Poisoning deliberate 23.30 10.72 17 269331 7327 31420669
Drug dependence 22.98 10.72 106 269242 22473 31405523
Dystonia 22.93 10.72 32 269316 10193 31417803
Intervertebral disc degeneration 22.88 10.72 101 269247 5470 31422526
Rheumatoid nodule 22.86 10.72 62 269286 2619 31425377
Eosinophilia 22.60 10.72 111 269237 23142 31404854
Low birth weight baby 22.57 10.72 118 269230 6852 31421144
Victim of child abuse 22.56 10.72 33 269315 879 31427117
Ventricular tachycardia 22.54 10.72 114 269234 23587 31404409
Jaundice neonatal 22.52 10.72 40 269308 1260 31426736
Hypermobility syndrome 22.51 10.72 21 269327 339 31427657
Intraductal papillary mucinous neoplasm 22.35 10.72 25 269323 505 31427491
Chronic graft versus host disease 22.27 10.72 5 269343 4387 31423609
Anaphylactic shock 22.21 10.72 55 269293 14090 31413906
Haematotoxicity 22.03 10.72 17 269331 7120 31420876
Atrioventricular septal defect 21.99 10.72 17 269331 209 31427787
Developmental delay 21.97 10.72 60 269288 2545 31425451
Synovitis 21.94 10.72 179 269169 12104 31415892
Spinal fracture 21.89 10.72 116 269232 6772 31421224
Urinary tract infection 21.84 10.72 829 268519 76040 31351956
Unresponsive to stimuli 21.84 10.72 129 269219 25671 31402325
Hepatotoxicity 21.80 10.72 86 269262 19040 31408956
Trisomy 18 21.78 10.72 21 269327 354 31427642
Renal impairment 21.67 10.72 563 268785 85786 31342210
Urticaria 21.58 10.72 351 268997 57166 31370830
Neurodevelopmental disorder 21.54 10.72 22 269326 399 31427597
Talipes 21.37 10.72 48 269300 1798 31426198
Posterior reversible encephalopathy syndrome 21.32 10.72 29 269319 9338 31418658
Pulmonary fibrosis 21.29 10.72 226 269122 16434 31411562
Delirium 21.27 10.72 237 269111 41184 31386812
Bronchial secretion retention 21.24 10.72 39 269309 1261 31426735
Thrombocytopenia 21.17 10.72 994 268354 141753 31286243
Language disorder 21.09 10.72 52 269296 2071 31425925
Ventricular septal defect 21.05 10.72 74 269274 3603 31424393
Blood pressure diastolic abnormal 21.02 10.72 78 269270 3901 31424095
Coronary artery disease 20.87 10.72 271 269077 45816 31382180
C-reactive protein abnormal 20.82 10.72 125 269223 7644 31420352
Hyperthermia 20.79 10.72 33 269315 9971 31418025
Septic shock 20.65 10.72 417 268931 65741 31362255
Congenital central nervous system anomaly 20.55 10.72 24 269324 509 31427487
Right atrial hypertrophy 20.54 10.72 26 269322 601 31427395
Vitamin B12 deficiency 20.30 10.72 71 269277 3448 31424548
Renal cyst haemorrhage 20.29 10.72 25 269323 562 31427434
Congenital hand malformation 20.18 10.72 25 269323 565 31427431
Dysgraphia 20.15 10.72 52 269296 2131 31425865
Serum ferritin increased 20.11 10.72 100 269248 5692 31422304
Aggression 20.10 10.72 211 269137 37080 31390916
Hypertonic bladder 20.05 10.72 45 269303 1685 31426311
Full blood count decreased 20.04 10.72 222 269126 16318 31411678
Multimorbidity 19.99 10.72 28 269320 716 31427280
Myoclonus 19.99 10.72 57 269291 13933 31414063
Acute graft versus host disease in skin 19.98 10.72 8 269340 4824 31423172
Appendicolith 19.89 10.72 12 269336 5719 31422277
Inguinal hernia 19.84 10.72 114 269234 6861 31421135
Graft versus host disease in gastrointestinal tract 19.70 10.72 3 269345 3476 31424520
Drug ineffective for unapproved indication 19.64 10.72 81 269267 17709 31410287
Melanoderma 19.62 10.72 14 269334 151 31427845
Spinal stenosis 19.44 10.72 86 269262 4662 31423334
Muscle spasticity 19.36 10.72 97 269251 5538 31422458
Right ventricular hypertrophy 19.36 10.72 37 269311 1234 31426762
Bradycardia 19.31 10.72 445 268903 68882 31359114
Electrocardiogram QRS complex prolonged 19.20 10.72 6 269342 4223 31423773
Macrocephaly 19.16 10.72 22 269326 458 31427538
Tongue disorder 19.14 10.72 89 269259 4928 31423068
Myelosuppression 19.04 10.72 64 269284 14856 31413140
Miosis 19.04 10.72 27 269321 8543 31419453
Exposure via breast milk 18.95 10.72 46 269302 1814 31426182
Plagiocephaly 18.94 10.72 23 269325 509 31427487
Angina pectoris 18.84 10.72 161 269187 29480 31398516
Anal fissure 18.77 10.72 68 269280 3361 31424635
Body height decreased 18.73 10.72 69 269279 3438 31424558
Nephropathy toxic 18.73 10.72 43 269305 11310 31416686
Oesophageal adenocarcinoma 18.66 10.72 29 269319 816 31427180
Localised infection 18.55 10.72 205 269143 15060 31412936
Graft versus host disease 18.54 10.72 38 269310 10409 31417587
Mydriasis 18.51 10.72 17 269331 6535 31421461
Grip strength decreased 18.51 10.72 57 269291 2589 31425407
Rectal prolapse 18.44 10.72 21 269327 433 31427563
Pancreatic failure 18.44 10.72 27 269321 720 31427276
Blood pressure systolic abnormal 18.43 10.72 63 269285 3024 31424972
Hypercalcaemia 18.40 10.72 191 269157 13809 31414187
Mobility decreased 18.40 10.72 332 269016 27137 31400859
Status epilepticus 18.29 10.72 48 269300 12058 31415938
Back disorder 18.27 10.72 101 269247 5992 31422004
Tendonitis 18.24 10.72 130 269218 8428 31419568
Metabolic acidosis 18.19 10.72 232 269116 39345 31388651
Benign prostatic hyperplasia 18.18 10.72 181 269167 12944 31415052
Akathisia 18.03 10.72 21 269327 7232 31420764
Heart rate decreased 18.02 10.72 339 269009 27927 31400069
Motor developmental delay 17.98 10.72 25 269323 635 31427361
Off label use 17.97 10.72 2633 266715 344641 31083355
Melaena 17.91 10.72 184 269164 32470 31395526
Sleep apnoea syndrome 17.79 10.72 239 269109 18386 31409610
Nocardiosis 17.77 10.72 4 269344 3503 31424493
Large for dates baby 17.54 10.72 29 269319 861 31427135
Blood 25-hydroxycholecalciferol decreased 17.47 10.72 15 269333 216 31427780
Intentional dose omission 17.45 10.72 58 269290 2744 31425252
Hypochromasia 17.38 10.72 17 269331 292 31427704
Asphyxia 17.37 10.72 14 269334 5737 31422259
Withdrawal syndrome 17.29 10.72 47 269301 11670 31416326
Blood lactic acid increased 17.21 10.72 16 269332 6114 31421882
Night sweats 17.20 10.72 207 269141 15525 31412471
Cytomegalovirus chorioretinitis 17.19 10.72 4 269344 3424 31424572
Haemodynamic instability 17.15 10.72 29 269319 8546 31419450
Cerebral haemorrhage 17.14 10.72 187 269161 32625 31395371
Abdominal wall haemorrhage 17.10 10.72 20 269328 425 31427571
Coagulopathy 17.07 10.72 90 269258 18425 31409571
Microcephaly 17.04 10.72 27 269321 773 31427223
Wrong technique in product usage process 17.03 10.72 191 269157 33152 31394844
Spinal osteoarthritis 16.97 10.72 109 269239 6826 31421170
Cardiotoxicity 16.80 10.72 11 269337 5016 31422980
Central nervous system lesion 16.78 10.72 97 269251 5851 31422145
Lower respiratory tract infection 16.76 10.72 335 269013 27902 31400094
Knee deformity 16.69 10.72 23 269325 579 31427417
Thrombotic microangiopathy 16.60 10.72 34 269314 9317 31418679
Blood pressure increased 16.44 10.72 831 268517 78802 31349194
Hypertransaminasaemia 16.42 10.72 8 269340 4296 31423700
Pulmonary alveolar haemorrhage 16.38 10.72 20 269328 6746 31421250
Sexual dysfunction 16.26 10.72 16 269332 5952 31422044
Tooth fracture 16.22 10.72 64 269284 3295 31424701
Soft tissue mass 16.20 10.72 27 269321 807 31427189
Fracture 16.17 10.72 100 269248 6180 31421816
Pyrexia 16.13 10.72 2300 267048 301540 31126456
Spinal disorder 16.05 10.72 71 269277 3849 31424147
Lipodystrophy acquired 15.99 10.72 4 269344 3260 31424736
Hip fracture 15.95 10.72 153 269195 10833 31417163
Aplastic anaemia 15.84 10.72 133 269215 9070 31418926
Hepatitis fulminant 15.82 10.72 6 269342 3740 31424256
Haemodialysis 15.81 10.72 39 269309 10006 31417990
Malignant melanoma 15.81 10.72 116 269232 7591 31420405
Torsade de pointes 15.80 10.72 21 269327 6829 31421167
Tumour lysis syndrome 15.79 10.72 72 269276 15313 31412683
Cerebral infarction 15.67 10.72 143 269205 25834 31402162
Post procedural infection 15.64 10.72 78 269270 4445 31423551
Aortic valve stenosis 15.56 10.72 51 269297 2395 31425601
Anuria 15.53 10.72 38 269310 9776 31418220
Umbilical hernia 15.53 10.72 74 269274 4140 31423856
Anal fistula 15.51 10.72 81 269267 4702 31423294
Hand deformity 15.49 10.72 59 269289 2988 31425008
Atypical fracture 15.46 10.72 11 269337 118 31427878
Maternal exposure before pregnancy 15.40 10.72 24 269324 677 31427319
Cellulitis 15.39 10.72 525 268823 47493 31380503
Rhinorrhoea 15.37 10.72 278 269070 22734 31405262
Systemic infection 15.30 10.72 64 269284 3385 31424611
Polyarthritis 15.19 10.72 74 269274 4178 31423818
Drug abuser 15.12 10.72 7 269341 3873 31424123
Nocturia 15.12 10.72 132 269216 9103 31418893
Hydrocele 15.08 10.72 44 269304 1939 31426057
Phospholipidosis 15.05 10.72 8 269340 48 31427948
Monoparesis 14.99 10.72 46 269302 2085 31425911
Loss of personal independence in daily activities 14.96 10.72 330 269018 27958 31400038
Kidney infection 14.95 10.72 81 269267 4769 31423227
Congenital hydronephrosis 14.95 10.72 24 269324 695 31427301
Tubulointerstitial nephritis 14.86 10.72 94 269254 18402 31409594
Drug eruption 14.83 10.72 92 269256 18095 31409901
Second primary malignancy 14.80 10.72 23 269325 7009 31420987
Mucous stools 14.77 10.72 35 269313 1359 31426637
Dyspraxia 14.73 10.72 18 269330 401 31427595
Oropharyngeal pain 14.72 10.72 361 268987 31122 31396874
Ear disorder 14.72 10.72 35 269313 1362 31426634
Blood test abnormal 14.71 10.72 96 269252 6045 31421951
Proteinuria 14.62 10.72 83 269265 16680 31411316
Polyomavirus-associated nephropathy 14.60 10.72 6 269342 3562 31424434
Diabetic ketoacidosis 14.59 10.72 84 269264 16821 31411175
Dandy-Walker syndrome 14.55 10.72 13 269335 198 31427798
Dyslexia 14.51 10.72 16 269332 318 31427678
Hyperbilirubinaemia neonatal 14.39 10.72 24 269324 718 31427278
Hyperammonaemia 14.38 10.72 17 269331 5816 31422180
Contusion 14.35 10.72 375 268973 32653 31395343
Mental status changes 14.33 10.72 217 269131 35751 31392245
Drug use disorder 14.31 10.72 8 269340 3975 31424021
Pancreatitis 14.19 10.72 216 269132 35555 31392441
Mania 14.16 10.72 36 269312 9141 31418855
Hyperparathyroidism secondary 14.11 10.72 36 269312 1465 31426531
Urosepsis 14.06 10.72 157 269191 11563 31416433
Productive cough 14.05 10.72 379 268969 33161 31394835
Viral acanthoma 14.03 10.72 6 269342 20 31427976
Gastrointestinal infection 14.01 10.72 79 269269 4721 31423275
Cholelithiasis 13.97 10.72 238 269110 19241 31408755
Selective eating disorder 13.89 10.72 39 269309 1681 31426315
Weight increased 13.87 10.72 849 268499 82098 31345898
Blood parathyroid hormone decreased 13.80 10.72 33 269315 1289 31426707
Disinhibition 13.79 10.72 3 269345 2690 31425306
Vascular compression 13.75 10.72 16 269332 338 31427658
Obsessive-compulsive disorder 13.72 10.72 13 269335 4924 31423072
Gastrointestinal stoma complication 13.70 10.72 31 269317 1167 31426829
Emotional distress 13.68 10.72 69 269279 14287 31413709
Anaphylactic reaction 13.67 10.72 173 269175 29380 31398616
Blood pressure systolic increased 13.64 10.72 237 269111 19233 31408763
Bronchitis 13.61 10.72 428 268920 38289 31389707
Heparin-induced thrombocytopenia 13.58 10.72 15 269333 5291 31422705
Strabismus 13.55 10.72 37 269311 1569 31426427
Frequent bowel movements 13.54 10.72 139 269209 10020 31417976
Virologic failure 13.48 10.72 5 269343 3160 31424836
Epstein-Barr virus infection 13.46 10.72 24 269324 6929 31421067
Immunodeficiency 13.42 10.72 77 269271 4632 31423364
Headache 13.42 10.72 1769 267579 181883 31246113
Gastrooesophageal reflux disease 13.41 10.72 380 268968 33491 31394505
Urine calcium/creatinine ratio increased 13.40 10.72 6 269342 23 31427973
Pneumonia aspiration 13.33 10.72 240 269108 38486 31389510
Hypophosphatasia 13.31 10.72 7 269341 41 31427955
Apparent death 13.30 10.72 7 269341 3598 31424398
Hyperhidrosis 13.27 10.72 454 268894 66939 31361057
Gastric haemorrhage 13.25 10.72 41 269307 9764 31418232
Cervical radiculopathy 13.25 10.72 16 269332 352 31427644
Lacrimal disorder 13.22 10.72 15 269333 308 31427688
Abdominal discomfort 13.21 10.72 550 268798 51017 31376979
Gastrointestinal haemorrhage 13.20 10.72 570 268778 81979 31346017
Euglycaemic diabetic ketoacidosis 13.19 10.72 4 269344 2870 31425126
Right atrial enlargement 13.17 10.72 13 269335 226 31427770
Psychomotor hyperactivity 13.15 10.72 35 269313 8752 31419244
Phlebitis infective 13.14 10.72 10 269338 120 31427876
Haemoglobin decreased 13.13 10.72 1120 268228 111555 31316441
Cyst 13.09 10.72 70 269278 4100 31423896
Hepatitis B 13.05 10.72 18 269330 5763 31422233
Blood creatinine increased 13.05 10.72 621 268727 88457 31339539
Low turnover osteopathy 13.01 10.72 9 269339 92 31427904
Neck pain 13.00 10.72 270 269078 22640 31405356
Bronchiolitis 12.97 10.72 54 269294 2850 31425146
Impaired healing 12.95 10.72 180 269168 13952 31414044
Scoliosis 12.94 10.72 50 269298 2549 31425447
Hyperparathyroidism 12.91 10.72 30 269318 1150 31426846
SARS-CoV-2 antibody test positive 12.87 10.72 16 269332 363 31427633
Respiratory tract infection viral 12.82 10.72 42 269306 1972 31426024
Impaired fasting glucose 12.80 10.72 12 269336 195 31427801
Agranulocytosis 12.80 10.72 117 269231 21130 31406866
Colitis ulcerative 12.78 10.72 225 269123 18304 31409692
Weight decrease neonatal 12.78 10.72 15 269333 320 31427676
Renal injury 12.77 10.72 47 269301 10618 31417378
Extrapyramidal disorder 12.77 10.72 54 269294 11724 31416272
Otitis media 12.76 10.72 50 269298 2566 31425430
Hepatitis B reactivation 12.73 10.72 7 269341 3511 31424485
Urge incontinence 12.72 10.72 19 269329 516 31427480
Upper limb fracture 12.71 10.72 71 269277 4228 31423768
Renal aplasia 12.68 10.72 22 269326 680 31427316
Diverticular perforation 12.67 10.72 57 269291 3112 31424884
Infusion related reaction 12.64 10.72 514 268834 47541 31380455
Arthropod bite 12.64 10.72 49 269299 2502 31425494
Loss of consciousness 12.61 10.72 533 268815 76822 31351174
Tarsal tunnel syndrome 12.59 10.72 5 269343 13 31427983
Vascular stent thrombosis 12.56 10.72 4 269344 2781 31425215
Gait disturbance 12.55 10.72 791 268557 76704 31351292
Injury 12.55 10.72 107 269241 19602 31408394
Femur fracture 12.51 10.72 108 269240 7425 31420571
Perineal cyst 12.50 10.72 13 269335 241 31427755
Knee arthroplasty 12.49 10.72 97 269251 6461 31421535
Bacterial disease carrier 12.45 10.72 17 269331 424 31427572
Enterocolitis 12.45 10.72 27 269321 7247 31420749
Drug intolerance 12.44 10.72 551 268797 51482 31376514
Ventricular hyperkinesia 12.41 10.72 12 269336 203 31427793
Therapy partial responder 12.39 10.72 23 269325 6539 31421457
Haematocrit decreased 12.39 10.72 339 269009 29722 31398274
Rectal tenesmus 12.37 10.72 23 269325 751 31427245
Vena cava injury 12.32 10.72 14 269334 288 31427708
Weight fluctuation 12.31 10.72 74 269274 4528 31423468
C-reactive protein increased 12.26 10.72 518 268830 48132 31379864
Multiple-drug resistance 12.22 10.72 12 269336 4468 31423528
Multiple sclerosis 12.20 10.72 113 269235 7924 31420072
Diffuse large B-cell lymphoma recurrent 12.18 10.72 5 269343 2970 31425026
Aortic arteriosclerosis 12.13 10.72 68 269280 4055 31423941
Toxic encephalopathy 12.10 10.72 14 269334 4836 31423160
Weight gain poor 12.05 10.72 25 269323 886 31427110
Lip ulceration 12.01 10.72 22 269326 710 31427286
Akinesia 12.01 10.72 41 269307 1967 31426029
Red blood cell sedimentation rate increased 12 10.72 116 269232 8230 31419766
Medical device implantation 11.95 10.72 20 269328 600 31427396
Joint stiffness 11.91 10.72 134 269214 9887 31418109
Arthrodesis 11.90 10.72 17 269331 443 31427553
Hypotonia neonatal 11.90 10.72 31 269317 1278 31426718
Vascular anastomotic haemorrhage 11.88 10.72 13 269335 256 31427740
Abdominal adhesions 11.88 10.72 31 269317 1279 31426717
Bladder transitional cell carcinoma recurrent 11.87 10.72 10 269338 140 31427856
Haematochezia 11.87 10.72 438 268910 40026 31387970
Pectus excavatum 11.86 10.72 12 269336 215 31427781
Monocyte percentage increased 11.86 10.72 25 269323 896 31427100
Tachycardia 11.82 10.72 528 268820 75679 31352317
Pneumonia 11.79 10.72 3111 266237 332201 31095795
Nasal disorder 11.79 10.72 37 269311 1698 31426298
Compartment syndrome 11.75 10.72 4 269344 2667 31425329
Congenital bladder anomaly 11.73 10.72 13 269335 260 31427736
Accessory spleen 11.70 10.72 10 269338 143 31427853
C-reactive protein decreased 11.69 10.72 38 269310 1777 31426219
Limb reduction defect 11.69 10.72 13 269335 261 31427735
Trismus 11.68 10.72 3 269345 2402 31425594
Ileal stenosis 11.66 10.72 30 269318 1227 31426769
Anhedonia 11.63 10.72 29 269319 7413 31420583
Hypersomnia 11.59 10.72 145 269203 10974 31417022
Alcohol abuse 11.58 10.72 13 269335 4551 31423445
Congenital anomaly 11.51 10.72 31 269317 1304 31426692
Diarrhoea 11.48 10.72 3259 266089 349150 31078846
Cleft lip 11.45 10.72 14 269334 312 31427684
Middle ear effusion 11.42 10.72 19 269329 567 31427429
Fibula fracture 11.38 10.72 22 269326 740 31427256
Asthenia 11.35 10.72 2121 267227 222634 31205362
Excessive skin 11.33 10.72 3 269345 0 31427996
Menopausal symptoms 11.33 10.72 3 269345 0 31427996
Hypnopompic hallucination 11.33 10.72 3 269345 0 31427996
Gallbladder mucocoele 11.33 10.72 3 269345 0 31427996
Ceruloplasmin decreased 11.33 10.72 3 269345 0 31427996
Nephrocalcinosis 11.33 10.72 19 269329 571 31427425
Nodule 11.31 10.72 85 269263 5605 31422391
Acne 11.25 10.72 134 269214 10026 31417970
Exposure to toxic agent 11.22 10.72 4 269344 2591 31425405
Respiratory disorder neonatal 11.21 10.72 33 269315 1462 31426534
Rib fracture 11.16 10.72 167 269181 13149 31414847
Hepatocellular injury 11.16 10.72 123 269225 21421 31406575
Latent tuberculosis 11.14 10.72 29 269319 1195 31426801
Post-traumatic headache 11.13 10.72 7 269341 60 31427936
Retinitis viral 11.08 10.72 8 269340 88 31427908
Inflammatory marker increased 11.06 10.72 67 269281 4111 31423885
Hepatitis cholestatic 11.05 10.72 28 269320 7118 31420878
Arnold-Chiari malformation 11.05 10.72 14 269334 324 31427672
Hepatic cyst 11.03 10.72 45 269303 2353 31425643
Coccydynia 11.03 10.72 17 269331 475 31427521
Haemorrhage intracranial 10.96 10.72 79 269269 15009 31412987
Drug level increased 10.96 10.72 114 269234 20072 31407924
Liver disorder 10.90 10.72 182 269166 29525 31398471
Hepatic cytolysis 10.90 10.72 51 269297 10772 31417224
Therapy non-responder 10.88 10.72 212 269136 33599 31394397
Drug screen positive 10.88 10.72 10 269338 3842 31424154
Catatonia 10.86 10.72 15 269333 4799 31423197
Haemangioma congenital 10.85 10.72 17 269331 482 31427514
Transplant rejection 10.84 10.72 44 269304 9664 31418332
Ankyloglossia congenital 10.83 10.72 13 269335 284 31427712
Hypoaesthesia 10.82 10.72 581 268767 55441 31372555
Hepatic haematoma 10.81 10.72 15 269333 380 31427616
Bronchial wall thickening 10.80 10.72 28 269320 1151 31426845
Acute coronary syndrome 10.79 10.72 64 269284 12725 31415271
Pulmonary function test decreased 10.78 10.72 69 269279 4316 31423680
Product complaint 10.76 10.72 19 269329 5505 31422491
Atypical fibroxanthoma 10.75 10.72 11 269337 200 31427796
Acute myeloid leukaemia 10.74 10.72 104 269244 18568 31409428

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 1680.80 10.38 231 766240 226904 69935069
Toxicity to various agents 1677.19 10.38 1029 765442 381143 69780830
Drug abuse 1058.22 10.38 163 766308 147093 70014880
Rheumatoid arthritis 646.45 10.38 5372 761099 286433 69875540
Drug interaction 591.64 10.38 2125 764346 379316 69782657
Intentional overdose 568.01 10.38 178 766293 98257 70063716
Arthralgia 520.42 10.38 7976 758495 495414 69666559
Arthropathy 438.65 10.38 2951 763520 147106 70014867
Joint swelling 432.91 10.38 4410 762061 248801 69913172
Overdose 425.16 10.38 738 765733 169007 69992966
Death 412.80 10.38 3527 762944 506534 69655439
Cardiac arrest 377.86 10.38 720 765751 159114 70002859
Pain 374.05 10.38 9159 757312 619657 69542316
Pemphigus 364.25 10.38 1819 764652 81217 70080756
Fatigue 362.09 10.38 11548 754923 812771 69349202
Systemic lupus erythematosus 358.15 10.38 2101 764370 99801 70062172
Alopecia 354.54 10.38 3489 762982 195001 69966972
Hand deformity 342.97 10.38 1842 764629 84640 70077333
Glossodynia 339.52 10.38 1837 764634 84650 70077323
Suicide attempt 335.68 10.38 223 766248 79287 70082686
Wound 310.50 10.38 1978 764493 96754 70065219
Depressed level of consciousness 296.35 10.38 304 766167 87127 70074846
Abdominal discomfort 293.78 10.38 3579 762892 211079 69950894
Hepatic function abnormal 293.45 10.38 186 766285 67810 70094163
Febrile neutropenia 289.30 10.38 1180 765291 203138 69958835
Synovitis 289.22 10.38 2386 764085 126842 70035131
Maternal exposure during pregnancy 281.23 10.38 2172 764299 113173 70048800
Acute kidney injury 279.17 10.38 3537 762934 471087 69690886
Nasopharyngitis 278.17 10.38 3644 762827 218562 69943411
Respiratory arrest 267.05 10.38 124 766347 53809 70108164
Cardio-respiratory arrest 259.07 10.38 430 766041 100247 70061726
Anti-cyclic citrullinated peptide antibody positive 254.30 10.38 1459 765012 68726 70093247
Pericarditis 242.07 10.38 1657 764814 83048 70078925
Peripheral swelling 236.55 10.38 3730 762741 232833 69929140
Sinusitis 232.26 10.38 2823 763648 166372 69995601
Multiple organ dysfunction syndrome 230.06 10.38 520 765951 107995 70053978
Coma 219.36 10.38 411 766060 91433 70070540
Infusion related reaction 218.88 10.38 3170 763301 194364 69967609
Renal failure 210.92 10.38 1189 765282 187881 69974092
Musculoskeletal stiffness 208.30 10.38 2478 763993 145282 70016691
Femur fracture 207.31 10.38 857 765614 35275 70126698
Drug resistance 206.49 10.38 77 766394 38113 70123860
Drug reaction with eosinophilia and systemic symptoms 205.48 10.38 194 766277 57819 70104154
Hypotension 200.44 10.38 3118 763353 401263 69760710
Rhabdomyolysis 187.05 10.38 479 765992 95281 70066692
Osteoarthritis 186.13 10.38 1406 765065 72741 70089232
Sedation 184.19 10.38 141 766330 46590 70115383
Serotonin syndrome 183.36 10.38 114 766357 42000 70119973
Swelling 179.46 10.38 2949 763522 185590 69976383
Discomfort 178.24 10.38 1833 764638 103603 70058370
Lactic acidosis 176.47 10.38 268 766203 64756 70097217
Cytomegalovirus infection 175.36 10.38 106 766365 39652 70122321
Cardiac failure 174.91 10.38 876 765595 142665 70019308
Impaired healing 171.04 10.38 1382 765089 72992 70088981
Malignant neoplasm progression 164.83 10.38 715 765756 121024 70040949
Pain in extremity 154.66 10.38 4640 761831 323442 69838531
Therapeutic product effect decreased 150.44 10.38 2275 764196 140743 70021230
Hepatic failure 149.26 10.38 245 766226 57380 70104593
Helicobacter infection 144.56 10.38 1064 765407 54592 70107381
Duodenal ulcer perforation 144.29 10.38 997 765474 50115 70111858
Fall 143.22 10.38 6014 760457 438082 69723891
Psoriatic arthropathy 142.72 10.38 1192 765279 63579 70098394
Disseminated intravascular coagulation 140.75 10.38 95 766376 33503 70128470
Myocardial infarction 138.74 10.38 1186 765285 170459 69991514
Poisoning 137.63 10.38 37 766434 22585 70139388
Shock 137.59 10.38 140 766331 40285 70121688
Respiratory failure 134.11 10.38 1171 765300 167564 69994409
Rheumatoid factor positive 133.63 10.38 939 765532 47461 70114512
Neutropenia 132.99 10.38 1966 764505 255190 69906783
Infective pulmonary exacerbation of cystic fibrosis 132.28 10.38 358 766113 11800 70150173
Weight increased 130.17 10.38 3485 762986 238846 69923127
Agitation 127.25 10.38 547 765924 92828 70069145
Intentional self-injury 125.36 10.38 95 766376 31555 70130418
Altered state of consciousness 124.77 10.38 149 766322 39873 70122100
Osteoporosis 123.62 10.38 929 765542 47978 70113995
Poisoning deliberate 122.20 10.38 19 766452 17041 70144932
Contraindicated product administered 121.24 10.38 2087 764384 132525 70029448
Electrocardiogram QT prolonged 120.82 10.38 478 765993 83039 70078934
Metabolic acidosis 120.41 10.38 406 766065 73940 70088033
Hepatic enzyme increased 118.48 10.38 2368 764103 154622 70007351
Multiple sclerosis relapse 117.84 10.38 833 765638 42184 70119789
Vitamin D deficiency 115.71 10.38 347 766124 12140 70149833
Bradycardia 115.14 10.38 830 765641 123785 70038188
Lower respiratory tract infection 114.50 10.38 1772 764699 110141 70051832
Drug hypersensitivity 111.57 10.38 2080 764391 260379 69901594
Thrombocytopenia 110.85 10.38 1866 764605 237244 69924729
Arthritis 110.63 10.38 1578 764893 96402 70065571
Product use in unapproved indication 109.75 10.38 1579 764892 205899 69956074
Mydriasis 109.10 10.38 21 766450 16132 70145841
Product use issue 108.73 10.38 2629 763842 177308 69984665
Exposure during pregnancy 108.53 10.38 1436 765035 86281 70075692
Product dose omission issue 106.26 10.38 3090 763381 214378 69947595
Sickle cell anaemia with crisis 103.36 10.38 211 766260 5767 70156206
Neuroleptic malignant syndrome 101.81 10.38 79 766392 25928 70136045
Blood creatine phosphokinase increased 100.27 10.38 333 766138 60930 70101043
Blood pressure fluctuation 98.77 10.38 1024 765447 57988 70103985
Red blood cell sedimentation rate abnormal 97.79 10.38 441 766030 18862 70143111
Hyperkalaemia 97.47 10.38 712 765759 105879 70056094
Somnolence 94.01 10.38 1701 764770 213905 69948068
Ventricular tachycardia 93.26 10.38 156 766315 36267 70125706
Acute hepatic failure 92.85 10.38 97 766374 27575 70134398
Knee arthroplasty 91.50 10.38 660 765811 33641 70128332
Disease progression 89.77 10.38 1173 765298 155499 70006474
Interstitial lung disease 88.33 10.38 715 765756 103970 70058003
Tooth disorder 88.23 10.38 500 765971 23438 70138535
Acute respiratory distress syndrome 87.96 10.38 197 766274 41057 70120916
Irritable bowel syndrome 86.82 10.38 886 765585 49964 70112009
Contusion 86.39 10.38 1900 764571 126136 70035837
Cardiogenic shock 86.20 10.38 163 766308 36144 70125829
Hypoglycaemia 85.95 10.38 631 765840 93733 70068240
Vitamin D decreased 85.60 10.38 242 766229 8185 70153788
Ventricular fibrillation 85.50 10.38 100 766371 27011 70134962
Hip arthroplasty 85.16 10.38 557 765914 27483 70134490
Muscle injury 85.09 10.38 709 765762 37785 70124188
Post transplant lymphoproliferative disorder 84.71 10.38 8 766463 10537 70151436
Intentional product misuse 83.64 10.38 510 765961 79085 70082888
Cardiac failure congestive 83.28 10.38 999 765472 134458 70027515
Musculoskeletal pain 82.60 10.38 1404 765067 88923 70073050
Septic shock 82.25 10.38 795 765676 111463 70050510
Low turnover osteopathy 81.21 10.38 101 766370 1781 70160192
Drug intolerance 80.84 10.38 3092 763379 222595 69939378
Foot fracture 80.74 10.38 422 766049 19178 70142795
Abortion spontaneous 80.42 10.38 526 765945 25953 70136020
Drug dependence 79.75 10.38 178 766293 37143 70124830
Sedation complication 79.59 10.38 23 766448 13387 70148586
Brain oedema 78.67 10.38 82 766389 23336 70138637
C-reactive protein abnormal 78.17 10.38 697 765774 37882 70124091
Urinary tract infection 77.99 10.38 3360 763111 245409 69916564
Mental status changes 77.44 10.38 384 766087 62717 70099256
Device expulsion 76.90 10.38 76 766395 22170 70139803
Renal impairment 76.22 10.38 1095 765376 142842 70019131
Angioedema 75.77 10.38 416 766055 66194 70095779
Sleep disorder due to general medical condition, insomnia type 75.74 10.38 652 765819 35080 70126893
Tooth fracture 75.68 10.38 270 766201 10357 70151616
Seizure 75.06 10.38 1412 765059 176550 69985423
Myelosuppression 74.54 10.38 132 766339 30013 70131960
Anaphylactic reaction 74.36 10.38 489 765982 74485 70087488
Folliculitis 74.25 10.38 745 765726 41825 70120148
Foot deformity 73.88 10.38 428 766043 20227 70141746
Toxic epidermal necrolysis 73.33 10.38 203 766268 39354 70122619
Injection site pruritus 73.18 10.38 696 765775 38514 70123459
Pathogen resistance 73.09 10.38 26 766445 13253 70148720
Sopor 72.81 10.38 142 766329 31125 70130848
Anaphylactic shock 72.71 10.38 151 766320 32339 70129634
Substance abuse 72.67 10.38 10 766461 9827 70152146
COVID-19 72.49 10.38 1573 764898 104184 70057789
Tachycardia 72.22 10.38 1241 765230 157305 70004668
Joint effusion 72.07 10.38 345 766126 15132 70146841
Miosis 72.03 10.38 31 766440 14070 70147903
Psoriasis 71.98 10.38 1478 764993 96955 70065018
Neurotoxicity 71.61 10.38 133 766338 29693 70132280
Myoclonus 71.13 10.38 109 766362 26246 70135727
Hepatotoxicity 70.67 10.38 241 766230 43745 70118228
Back pain 70.38 10.38 3594 762877 267558 69894415
Injection site reaction 70.15 10.38 836 765635 49016 70112957
Acute graft versus host disease 69.98 10.38 10 766461 9552 70152421
Unresponsive to stimuli 69.65 10.38 306 766165 51625 70110348
Fracture 69.22 10.38 410 766061 19534 70142439
Drug withdrawal syndrome 69.11 10.38 157 766314 32558 70129415
Pregnancy 68.36 10.38 466 766005 23315 70138658
Bronchopulmonary aspergillosis 67.82 10.38 76 766395 20926 70141047
Spinal osteoarthritis 67.80 10.38 337 766134 15011 70146962
Posterior reversible encephalopathy syndrome 67.73 10.38 99 766372 24303 70137670
Coagulopathy 67.49 10.38 163 766308 33086 70128887
Mucormycosis 67.35 10.38 5 766466 8009 70153964
Torsade de pointes 67.22 10.38 58 766413 18058 70143915
Delirium 66.96 10.38 501 765970 74113 70087860
Coronary artery disease 66.95 10.38 400 766071 62336 70099637
Cerebral infarction 66.85 10.38 239 766232 42770 70119203
Basal cell carcinoma 66.32 10.38 605 765866 33093 70128880
Venoocclusive liver disease 65.84 10.38 17 766454 10661 70151312
Palmar-plantar erythrodysaesthesia syndrome 65.66 10.38 143 766328 30104 70131869
Stevens-Johnson syndrome 65.28 10.38 186 766285 35721 70126252
Spinal fracture 65.16 10.38 346 766125 15821 70146152
Psychotic disorder 65.14 10.38 200 766271 37501 70124472
Drug ineffective for unapproved indication 64.78 10.38 207 766264 38331 70123642
Status epilepticus 64.70 10.38 103 766368 24423 70137550
Hypersensitivity 64.19 10.38 3068 763403 226744 69935229
Aspergillus infection 64.15 10.38 59 766412 17809 70144164
Aggression 64.04 10.38 287 766184 48159 70113814
Thrombotic microangiopathy 64.00 10.38 59 766412 17789 70144184
Encephalopathy 63.79 10.38 397 766074 61264 70100709
Ejection fraction decreased 63.08 10.38 150 766321 30612 70131361
Respiratory depression 62.97 10.38 107 766364 24724 70137249
Sepsis 62.96 10.38 2088 764383 242457 69919516
Injection site erythema 62.89 10.38 1123 765348 71801 70090172
Emotional distress 60.95 10.38 202 766269 36986 70124987
Haematotoxicity 60.94 10.38 36 766435 13638 70148335
Graft versus host disease 60.91 10.38 44 766427 14979 70146994
Dystonia 60.74 10.38 74 766397 19632 70142341
Pulmonary oedema 60.13 10.38 583 765888 81695 70080278
Extrapyramidal disorder 59.76 10.38 82 766389 20668 70141305
Fracture delayed union 59.43 10.38 91 766380 1968 70160005
Creatinine renal clearance decreased 59.18 10.38 59 766412 17141 70144832
Weight decreased 58.60 10.38 4000 762471 306488 69855485
Headache 58.36 10.38 7143 759328 573262 69588711
Blister 57.46 10.38 1458 765013 99068 70062905
Asphyxia 57.35 10.38 20 766451 10322 70151651
Drug level increased 56.45 10.38 203 766268 36266 70125707
Oropharyngeal pain 56.27 10.38 1401 765070 94909 70067064
Ascites 55.30 10.38 465 766006 67082 70094891
Blood cholesterol increased 55.05 10.38 993 765478 63611 70098362
Intervertebral disc degeneration 55.01 10.38 296 766175 13604 70148369
Hyperhidrosis 54.25 10.38 1048 765423 130538 70031435
International normalised ratio increased 53.65 10.38 585 765886 80141 70081832
Colorectal cancer 53.16 10.38 13 766458 8457 70153516
Transplant rejection 53.14 10.38 71 766400 18100 70143873
Cerebral haemorrhage 53.06 10.38 352 766119 53512 70108461
Acute generalised exanthematous pustulosis 52.76 10.38 53 766418 15344 70146629
Graft versus host disease in gastrointestinal tract 52.04 10.38 3 766468 5941 70156032
Hyperthermia 52.03 10.38 62 766409 16609 70145364
Angina pectoris 51.88 10.38 308 766163 48075 70113898
Hyponatraemia 51.70 10.38 1325 765146 158762 70003211
Gastrointestinal haemorrhage 51.70 10.38 1111 765360 136297 70025676
Night sweats 51.08 10.38 708 765763 42976 70118997
Osteopenia 50.89 10.38 332 766139 16365 70145608
Hypoxia 50.86 10.38 706 765765 92638 70069335
Bone density decreased 50.73 10.38 252 766219 11222 70150751
Suicidal ideation 50.49 10.38 494 765977 69102 70092871
Bone marrow failure 50.46 10.38 316 766155 48694 70113279
Loss of consciousness 50.24 10.38 1289 765182 154427 70007546
Localised infection 50.20 10.38 564 765907 32594 70129379
General physical health deterioration 50.17 10.38 3072 763399 232959 69929014
Acute myeloid leukaemia 50.06 10.38 169 766302 30771 70131202
Hypoaesthesia 49.37 10.38 2082 764389 151657 70010316
Injection site swelling 49.06 10.38 696 765775 42461 70119512
Blood bilirubin increased 48.75 10.38 413 766058 59488 70102485
Bone disorder 48.66 10.38 340 766131 17150 70144823
Haemodialysis 48.64 10.38 70 766401 17296 70144677
Hepatocellular injury 48.59 10.38 295 766176 45796 70116177
Akathisia 48.55 10.38 37 766434 12256 70149717
Bone loss 48.44 10.38 91 766380 2336 70159637
Fibromyalgia 48.16 10.38 756 765715 47118 70114855
Bone giant cell tumour 48.10 10.38 26 766445 122 70161851
Synovial cyst 47.53 10.38 204 766267 8538 70153435
Tumour lysis syndrome 47.19 10.38 100 766371 21260 70140713
Respiratory distress 47.13 10.38 371 766100 54279 70107694
Rash maculo-papular 46.98 10.38 336 766135 50209 70111764
Influenza 46.87 10.38 1583 764888 112117 70049856
Acute graft versus host disease in skin 46.70 10.38 10 766461 7127 70154846
Grip strength decreased 46.67 10.38 310 766161 15375 70146598
Condition aggravated 46.52 10.38 5290 761181 422345 69739628
Anhedonia 46.37 10.38 51 766420 14162 70147811
Eosinophilia 46.29 10.38 251 766220 40068 70121905
Bronchitis 46.24 10.38 1624 764847 115619 70046354
Red blood cell count decreased 45.95 10.38 806 765665 51355 70110618
Thoracic vertebral fracture 45.77 10.38 135 766336 4679 70157294
Orthostatic hypotension 45.68 10.38 349 766122 51394 70110579
Chronic graft versus host disease 45.30 10.38 9 766462 6761 70155212
Gait disturbance 45.26 10.38 2440 764031 182666 69979307
Joint stiffness 44.80 10.38 579 765892 34597 70127376
Neutrophil count decreased 44.80 10.38 634 765837 82922 70079051
Muscle spasticity 44.77 10.38 365 766106 19324 70142649
Rheumatic fever 44.36 10.38 335 766136 17325 70144648
Anuria 44.26 10.38 91 766380 19562 70142411
Syncope 44.02 10.38 1409 765062 164300 69997673
Injection site pain 43.88 10.38 1619 764852 116000 70045973
Ill-defined disorder 43.72 10.38 833 765638 53908 70108065
Pleural effusion 43.62 10.38 1097 765374 131767 70030206
Exostosis 43.58 10.38 285 766186 14060 70147913
Blood pressure diastolic abnormal 43.49 10.38 302 766169 15202 70146771
Disability assessment scale score increased 43.47 10.38 98 766373 2873 70159100
Red blood cell sedimentation rate increased 43.45 10.38 622 765849 38020 70123953
Tendonitis 42.94 10.38 396 766075 21726 70140247
Accidental overdose 42.93 10.38 214 766257 34907 70127066
Platelet count decreased 42.77 10.38 1535 764936 176687 69985286
Unintentional medical device removal 42.68 10.38 12 766459 7112 70154861
Endophthalmitis 42.52 10.38 8 766463 6247 70155726
Ear infection 42.45 10.38 481 765990 27855 70134118
Toxic skin eruption 42.39 10.38 97 766374 20065 70141908
Wrong technique in product usage process 42.07 10.38 507 765964 68191 70093782
Infection 41.59 10.38 2726 763745 208059 69953914
Gestational diabetes 41.48 10.38 151 766320 5850 70156123
Pulmonary arterial hypertension 41.43 10.38 198 766273 32657 70129316
Blood creatinine increased 41.40 10.38 1202 765269 141799 70020174
Enthesopathy 41.36 10.38 229 766242 10640 70151333
Epstein-Barr virus infection 41.28 10.38 49 766422 13149 70148824
Inappropriate antidiuretic hormone secretion 41.27 10.38 122 766349 23154 70138819
Plasma cell myeloma 41.19 10.38 550 765921 72651 70089322
Juvenile idiopathic arthritis 40.99 10.38 147 766324 5653 70156320
Ear pain 40.68 10.38 467 766004 27132 70134841
Melaena 40.46 10.38 401 766070 55954 70106019
Asthma 40.28 10.38 995 765476 119798 70042175
Gastrointestinal disorder 40.01 10.38 1454 765017 103973 70058000
Agranulocytosis 39.87 10.38 263 766208 40035 70121938
Body height decreased 39.56 10.38 178 766293 7605 70154368
Sinus tachycardia 39.56 10.38 210 766261 33703 70128270
Cyanosis 39.45 10.38 124 766347 23082 70138891
Acute myocardial infarction 39.44 10.38 552 765919 72335 70089638
Cardiotoxicity 39.21 10.38 37 766434 11033 70150940
Polyarthritis 39.20 10.38 224 766247 10532 70151441
Hypokalaemia 39.17 10.38 1098 765373 130090 70031883
Dental caries 38.99 10.38 230 766241 10941 70151032
Hyperglycaemia 38.95 10.38 479 765992 64193 70097780
Exposure via ingestion 38.77 10.38 4 766467 4911 70157062
Pulmonary alveolar haemorrhage 38.71 10.38 33 766438 10336 70151637
Hypothermia 38.68 10.38 105 766366 20489 70141484
Stress fracture 38.60 10.38 145 766326 5705 70156268
Laryngitis 38.52 10.38 266 766205 13365 70148608
Dry eye 38.47 10.38 525 765946 31757 70130216
Nocardiosis 38.40 10.38 5 766466 5124 70156849
Bone density abnormal 38.36 10.38 92 766379 2811 70159162
Blood pressure diastolic decreased 38.34 10.38 437 766034 25343 70136630
Blood pressure systolic abnormal 38.33 10.38 255 766216 12654 70149319
Haemodynamic instability 38.32 10.38 69 766402 15589 70146384
Electrocardiogram QRS complex prolonged 38.11 10.38 30 766441 9776 70152197
Atypical femur fracture 37.93 10.38 127 766344 4716 70157257
Immune reconstitution inflammatory syndrome 37.74 10.38 51 766420 12939 70149034
Proteinuria 37.64 10.38 176 766295 29198 70132775
Aspartate aminotransferase increased 37.34 10.38 1065 765406 125913 70036060
Accidental exposure to product 37.18 10.38 166 766305 27885 70134088
Febrile bone marrow aplasia 36.99 10.38 45 766426 11946 70150027
Multiple fractures 36.88 10.38 158 766313 6607 70155366
Swollen joint count increased 36.76 10.38 264 766207 13436 70148537
Renal injury 36.69 10.38 74 766397 16020 70145953
Acute coronary syndrome 36.51 10.38 104 766367 19975 70141998
Cataract 36.32 10.38 822 765649 54823 70107150
Joint injury 36.30 10.38 448 766023 26484 70135489
Pulseless electrical activity 36.30 10.38 54 766417 13161 70148812
Arrhythmia 36.05 10.38 410 766061 55733 70106240
Vomiting 35.86 10.38 5746 760725 587365 69574608
Toothache 35.82 10.38 330 766141 18100 70143873
Gait spastic 35.61 10.38 50 766421 997 70160976
Disorientation 35.27 10.38 428 766043 57495 70104478
Bronchospasm 35.19 10.38 127 766344 22665 70139308
Joint laxity 35.17 10.38 78 766393 2261 70159712
Wrist fracture 35.10 10.38 214 766257 10302 70151671
Heart rate decreased 35 10.38 898 765573 61117 70100856
Drug abuser 34.91 10.38 10 766461 5854 70156119
Nephrolithiasis 34.72 10.38 711 765760 46612 70115361
Injection site bruising 34.69 10.38 591 765880 37441 70124532
Haemophagocytic lymphohistiocytosis 34.62 10.38 103 766368 19509 70142464
Abnormal behaviour 34.60 10.38 226 766245 34483 70127490
Rash 34.58 10.38 6144 760327 504418 69657555
Polyomavirus-associated nephropathy 34.45 10.38 7 766464 5176 70156797
Toxic encephalopathy 34.33 10.38 37 766434 10369 70151604
BK virus infection 34.26 10.38 22 766449 7967 70154006
Drug use disorder 34.20 10.38 23 766448 8128 70153845
Upper respiratory tract infection 34.02 10.38 1109 765362 78165 70083808
Cystitis haemorrhagic 33.76 10.38 26 766445 8567 70153406
Device use error 33.76 10.38 15 766456 6681 70155292
Jaundice 33.74 10.38 362 766109 49746 70112227
Pulmonary embolism 33.73 10.38 1359 765112 154508 70007465
Pyrexia 33.70 10.38 5908 760563 601044 69560929
Nephropathy toxic 33.58 10.38 96 766375 18418 70143555
Spinal stenosis 33.51 10.38 272 766199 14381 70147592
Hyperammonaemia 33.51 10.38 37 766434 10256 70151717
Gastroenteritis viral 33.42 10.38 367 766104 21088 70140885
Myopathy 33.40 10.38 97 766374 18515 70143458
Inflammation 33.37 10.38 1099 765372 77566 70084407
Second primary malignancy 33.31 10.38 56 766415 12995 70148978
Multiple-drug resistance 33.29 10.38 19 766452 7336 70154637
Paradoxical drug reaction 33.24 10.38 15 766456 6621 70155352
Face oedema 33.22 10.38 153 766318 25486 70136487
Cough 33.20 10.38 4009 762462 321368 69840605
Hypercalcaemia 33.08 10.38 539 765932 33846 70128127
Loss of personal independence in daily activities 32.94 10.38 1174 765297 83736 70078237
Gastrooesophageal reflux disease 32.82 10.38 1246 765225 89593 70072380
Blood alkaline phosphatase increased 32.81 10.38 440 766031 58081 70103892
Poor venous access 32.69 10.38 275 766196 14696 70147277
Exposure to toxic agent 32.63 10.38 13 766458 6181 70155792
Metastases to liver 32.60 10.38 156 766315 25722 70136251
Memory impairment 32.59 10.38 1267 765204 91374 70070599
Oral herpes 32.46 10.38 402 766069 23784 70138189
Cystitis 32.40 10.38 699 765772 46242 70115731
Systemic infection 32.17 10.38 150 766321 6507 70155466
Hyperbilirubinaemia 32.10 10.38 130 766341 22438 70139535
Caesarean section 31.92 10.38 225 766246 11382 70150591
Leukopenia 31.77 10.38 892 765579 105668 70056305
Catatonia 31.46 10.38 25 766446 8108 70153865
Mouth ulceration 31.42 10.38 534 765937 33815 70128158
Restlessness 31.41 10.38 297 766174 41831 70120142
Blood pressure increased 31.30 10.38 2404 764067 186113 69975860
Live birth 31.10 10.38 255 766216 13524 70148449
Rhinorrhoea 30.98 10.38 938 765533 65433 70096540
Scoliosis 30.94 10.38 146 766325 6365 70155608
Cytomegalovirus viraemia 30.89 10.38 49 766422 11636 70150337
Cytokine release syndrome 30.81 10.38 164 766307 26303 70135670
Pancreatitis 30.66 10.38 484 765987 62184 70099789
Ileus 30.60 10.38 146 766325 24091 70137882
Blood pressure systolic increased 30.54 10.38 823 765648 56436 70105537
Increased tendency to bruise 30.48 10.38 194 766277 9481 70152492
Mania 30.46 10.38 90 766381 17084 70144889
Stomatitis 30.41 10.38 1689 764782 126822 70035151
Nodule 30.38 10.38 340 766131 19629 70142344
Blood lactic acid increased 30.35 10.38 46 766425 11127 70150846
Ileus paralytic 30.20 10.38 30 766441 8731 70153242
Tenosynovitis 30.13 10.38 256 766215 13720 70148253
Latent tuberculosis 30.13 10.38 88 766383 3033 70158940
Injection site rash 29.98 10.38 290 766181 16120 70145853
Pneumatosis intestinalis 29.98 10.38 13 766458 5874 70156099
Angina unstable 29.87 10.38 81 766390 15812 70146161
Appendicolith 29.80 10.38 12 766459 5668 70156305
Alanine aminotransferase increased 29.78 10.38 1296 765175 146184 70015789
Malignant melanoma 29.65 10.38 254 766217 13646 70148327
Drug screen positive 29.57 10.38 13 766458 5827 70156146
Bladder cancer 29.40 10.38 92 766379 17150 70144823
Herpes zoster 29.35 10.38 1163 765308 84072 70077901
Gamma-glutamyltransferase increased 29.18 10.38 379 766092 50306 70111667
Muscle spasms 29.08 10.38 1985 764486 152061 70009912
Cognitive disorder 29.08 10.38 473 765998 60483 70101490
Hallucination, auditory 29.05 10.38 101 766370 18227 70143746
Enterocolitis 29.00 10.38 61 766410 13005 70148968
Maternal exposure before pregnancy 28.94 10.38 99 766372 3717 70158256
Folate deficiency 28.83 10.38 85 766386 2945 70159028
Muscle rigidity 28.74 10.38 104 766367 18546 70143427
Breast cancer stage I 28.73 10.38 15 766456 6087 70155886
Myocardial ischaemia 28.70 10.38 149 766322 24051 70137922
Adenovirus infection 28.66 10.38 25 766446 7743 70154230
Cyst 28.50 10.38 235 766236 12484 70149489
Product quality issue 28.47 10.38 203 766268 30358 70131615
Hepatitis fulminant 28.39 10.38 18 766453 6563 70155410
Transplant dysfunction 28.32 10.38 20 766451 6889 70155084
Tubulointerstitial nephritis 28.30 10.38 225 766246 32851 70129122
Cerebrovascular accident 28.30 10.38 1264 765207 142206 70019767
Pneumothorax 27.99 10.38 164 766307 25682 70136291
Fracture nonunion 27.86 10.38 54 766417 1420 70160553
Tenderness 27.80 10.38 351 766120 20859 70141114
Joint destruction 27.65 10.38 112 766359 4566 70157407
Skin cancer 27.65 10.38 245 766226 13291 70148682
Limb discomfort 27.60 10.38 463 766008 29242 70132731
Blood pressure decreased 27.55 10.38 765 765706 90750 70071223
Hemiplegia 27.51 10.38 69 766402 13826 70148147
Vascular stent thrombosis 27.45 10.38 3 766468 3520 70158453
Burning sensation 27.37 10.38 757 765714 52113 70109860
Respiratory acidosis 27.29 10.38 43 766428 10238 70151735
Venoocclusive disease 27.25 10.38 6 766465 4194 70157779
Cholestasis 27.18 10.38 359 766112 47513 70114460
Sciatica 27.13 10.38 395 766076 24232 70137741
Fear 27.08 10.38 124 766347 20687 70141286
Tremor 26.96 10.38 1390 765081 154234 70007739
Haemorrhage intracranial 26.95 10.38 157 766314 24620 70137353
Tongue disorder 26.81 10.38 239 766232 12988 70148985
Mobility decreased 26.62 10.38 1365 765106 101634 70060339
Cytomegalovirus chorioretinitis 26.50 10.38 12 766459 5286 70156687
Abdominal pain upper 26.30 10.38 2432 764039 191170 69970803
Carpal tunnel syndrome 26.21 10.38 291 766180 16766 70145207
Joint dislocation 26.16 10.38 256 766215 14275 70147698
Acidosis 26.10 10.38 105 766366 18158 70143815
Pneumocystis jirovecii pneumonia 26.03 10.38 204 766267 29878 70132095
Psychomotor hyperactivity 25.86 10.38 83 766388 15350 70146623
Alcohol interaction 25.80 10.38 9 766462 4644 70157329
Erythema multiforme 25.77 10.38 92 766379 16472 70145501
Heparin-induced thrombocytopenia 25.73 10.38 36 766435 9001 70152972
Anaemia 25.70 10.38 3896 762575 399527 69762446
Hepatitis cholestatic 25.68 10.38 62 766409 12588 70149385
Neck deformity 25.67 10.38 58 766413 1703 70160270
Hepatitis B reactivation 25.46 10.38 13 766458 5342 70156631
Therapy partial responder 25.43 10.38 61 766410 12413 70149560
Treatment failure 25.41 10.38 1847 764624 142295 70019678
Full blood count decreased 25.32 10.38 381 766090 23537 70138436
Musculoskeletal discomfort 25.06 10.38 299 766172 17533 70144440
Surgery 24.86 10.38 459 766012 29530 70132443
Graft versus host disease in skin 24.84 10.38 15 766456 5615 70156358
Lumbar vertebral fracture 24.72 10.38 129 766342 5858 70156115
Hepatic encephalopathy 24.68 10.38 139 766332 21979 70139994
Cross sensitivity reaction 24.62 10.38 4 766467 3474 70158499
Diffuse large B-cell lymphoma recurrent 24.60 10.38 4 766467 3472 70158501
Accidental death 24.52 10.38 6 766465 3902 70158071
Rheumatoid nodule 24.52 10.38 260 766211 14807 70147166
Pulmonary congestion 24.46 10.38 165 766306 24989 70136984
Hypoalbuminaemia 24.25 10.38 115 766356 19007 70142966
Haematochezia 24.19 10.38 993 765478 72088 70089885
Thyroid mass 24.02 10.38 88 766383 3420 70158553
Humerus fracture 23.98 10.38 164 766307 8214 70153759
Breast cancer stage II 23.93 10.38 14 766457 5332 70156641
Bone erosion 23.84 10.38 260 766211 14913 70147060
Alanine aminotransferase abnormal 23.81 10.38 159 766312 7900 70154073
Potentiating drug interaction 23.77 10.38 32 766439 8132 70153841
C-reactive protein increased 23.74 10.38 1440 765031 109077 70052896
Dermatitis exfoliative 23.64 10.38 49 766422 10502 70151471
Oral infection 23.60 10.38 116 766355 5143 70156830
Mean cell volume increased 23.58 10.38 122 766349 5522 70156451
Smear cervix abnormal 23.55 10.38 68 766403 2328 70159645
Neck pain 23.53 10.38 912 765559 65745 70096228
Purpura 23.45 10.38 107 766364 17868 70144105
Irritability 23.44 10.38 282 766189 37943 70124030
Vitamin D increased 23.42 10.38 29 766442 509 70161464
Blood glucose increased 23.34 10.38 893 765578 102089 70059884
Tibia fracture 23.26 10.38 110 766361 4800 70157173
Product complaint 23.24 10.38 62 766409 12169 70149804
Ankle fracture 23.23 10.38 261 766210 15083 70146890
Gingival recession 23.18 10.38 43 766428 1093 70160880
Haemorrhage 23.13 10.38 709 765762 83106 70078867
Hyperparathyroidism 23.07 10.38 79 766392 2968 70159005
Upper respiratory tract inflammation 22.96 10.38 7 766464 3935 70158038
Metabolic disorder 22.92 10.38 32 766439 8008 70153965
Abortion incomplete 22.89 10.38 3 766468 3059 70158914
Cardiac failure acute 22.87 10.38 104 766367 17383 70144590
Blood parathyroid hormone increased 22.84 10.38 82 766389 3155 70158818
Dyspnoea 22.82 10.38 7716 758755 762344 69399629
Human herpesvirus 6 infection 22.80 10.38 12 766459 4847 70157126
Stress cardiomyopathy 22.78 10.38 45 766426 9817 70152156
Rotator cuff syndrome 22.76 10.38 224 766247 12510 70149463
Pulmonary fibrosis 22.75 10.38 508 765963 33802 70128171
Pneumonia aspiration 22.73 10.38 506 765965 61783 70100190
Leukocytosis 22.69 10.38 297 766174 39371 70122602
Joint noise 22.60 10.38 85 766386 3346 70158627
Gastric haemorrhage 22.59 10.38 78 766393 14107 70147866
Pulmonary haemorrhage 22.59 10.38 74 766397 13599 70148374
Adverse event 22.54 10.38 697 765774 48764 70113209
Bradyphrenia 22.44 10.38 46 766425 9900 70152073
Withdrawal syndrome 22.44 10.38 167 766304 24737 70137236
Needle fatigue 22.42 10.38 34 766437 729 70161244
Jaw disorder 22.25 10.38 106 766365 4640 70157333
Hallucination, visual 22.23 10.38 206 766265 29131 70132842
Aphthous ulcer 22.05 10.38 249 766222 14407 70147566
Paraesthesia 22.05 10.38 1843 764628 143694 70018279
Intentional product use issue 21.95 10.38 1544 764927 118598 70043375
Acute graft versus host disease in intestine 21.82 10.38 7 766464 3809 70158164
Vasoplegia syndrome 21.53 10.38 4 766467 3152 70158821
Cytopenia 21.49 10.38 105 766366 17218 70144755
Squamous cell carcinoma of skin 21.46 10.38 221 766250 12491 70149482
Disability 21.40 10.38 252 766219 14731 70147242
Device difficult to use 21.38 10.38 54 766417 10795 70151178
Prothrombin time prolonged 21.34 10.38 96 766375 16094 70145879
Skin papilloma 21.31 10.38 115 766356 5291 70156682
Lupus-like syndrome 21.28 10.38 204 766267 11311 70150662
Upper limb fracture 21.23 10.38 267 766204 15852 70146121
Skin toxicity 21.18 10.38 28 766443 7170 70154803
Intestinal stenosis 21.02 10.38 82 766389 3285 70158688
Bursitis 20.99 10.38 405 766066 26268 70135705
No adverse event 20.96 10.38 234 766237 31919 70130054
Bradypnoea 20.84 10.38 17 766454 5442 70156531
Anti-neutrophil cytoplasmic antibody positive vasculitis 20.81 10.38 5 766466 3292 70158681
Breast cancer 20.78 10.38 492 765979 33057 70128916
Paranoia 20.75 10.38 106 766365 17182 70144791
Blood pressure diastolic increased 20.72 10.38 215 766256 12176 70149797
Tardive dyskinesia 20.69 10.38 48 766423 9881 70152092
Diabetic ketoacidosis 20.67 10.38 229 766242 31283 70130690
Cholecystitis chronic 20.62 10.38 44 766427 9332 70152641
Nasal congestion 20.53 10.38 887 765584 64785 70097188
Frequent bowel movements 20.50 10.38 332 766139 20821 70141152
Dermatitis acneiform 20.50 10.38 41 766430 8904 70153069
Left ventricular dysfunction 20.50 10.38 112 766359 17845 70144128
Coronary arterial stent insertion 20.48 10.38 20 766451 5867 70156106
Injection site urticaria 20.45 10.38 204 766267 11434 70150539
Drug-induced liver injury 20.43 10.38 456 766015 55657 70106316
Virologic failure 20.42 10.38 8 766463 3842 70158131
Acute lung injury 20.41 10.38 3 766468 2806 70159167
Lethargy 20.41 10.38 638 765833 74612 70087361
Peripheral sensory neuropathy 20.38 10.38 65 766406 12045 70149928
Lower respiratory tract infection viral 20.37 10.38 40 766431 1062 70160911
Meniscus injury 20.27 10.38 125 766346 6042 70155931
Limb injury 20.26 10.38 391 766080 25361 70136612
Hip fracture 20.20 10.38 423 766048 27840 70134133
Joint range of motion decreased 20.08 10.38 394 766077 25632 70136341
Dysarthria 20.03 10.38 516 765955 61797 70100176
Gingival disorder 20.02 10.38 82 766389 3360 70158613
Generalised tonic-clonic seizure 19.96 10.38 323 766148 41338 70120635
Visual acuity reduced 19.94 10.38 199 766272 27731 70134242
Spinal disorder 19.94 10.38 169 766302 9051 70152922
Metastases to central nervous system 19.90 10.38 89 766382 14945 70147028
Anaemia postoperative 19.86 10.38 53 766418 1732 70160241
Osteonecrosis of jaw 19.82 10.38 582 765889 40420 70121553
Tooth abscess 19.80 10.38 243 766228 14346 70147627
Relapsing-remitting multiple sclerosis 19.77 10.38 45 766426 1328 70160645
Limb deformity 19.72 10.38 82 766389 3383 70158590
Sexual dysfunction 19.64 10.38 26 766445 6655 70155318
Hepatitis B 19.64 10.38 36 766435 8078 70153895
Eye infection 19.58 10.38 181 766290 9937 70152036
Post procedural infection 19.43 10.38 184 766287 10169 70151804
Nephrotic syndrome 19.42 10.38 55 766416 10585 70151388
Temperature regulation disorder 19.38 10.38 12 766459 4432 70157541
Cytomegalovirus infection reactivation 19.32 10.38 27 766444 6754 70155219
Fungaemia 19.27 10.38 10 766461 4072 70157901
Aortic valve stenosis 19.22 10.38 105 766366 4854 70157119
Reversible cerebral vasoconstriction syndrome 19.21 10.38 3 766468 2682 70159291
Mitochondrial toxicity 19.20 10.38 4 766467 2906 70159067
Dental implantation 19.18 10.38 24 766447 426 70161547
Pemphigoid 19.18 10.38 82 766389 13940 70148033
Polyhydramnios 19.12 10.38 47 766424 1459 70160514
Acute lymphocytic leukaemia recurrent 19.06 10.38 15 766456 4889 70157084
Red blood cell sedimentation rate 19.05 10.38 104 766367 4806 70157167
Ligament rupture 18.99 10.38 72 766399 2845 70159128
Spondylolisthesis 18.87 10.38 72 766399 2854 70159119
Oliguria 18.80 10.38 91 766380 14960 70147013
Intraductal proliferative breast lesion 18.77 10.38 61 766410 2230 70159743
Intraductal papillary mucinous neoplasm 18.76 10.38 32 766439 760 70161213
Renal tubular necrosis 18.74 10.38 160 766311 23011 70138962
Persecutory delusion 18.61 10.38 13 766458 4504 70157469
Aplasia 18.61 10.38 31 766440 7220 70154753
Acute myeloid leukaemia recurrent 18.57 10.38 5 766466 3049 70158924
Bone pain 18.57 10.38 698 765773 50124 70111849
Spinal pain 18.53 10.38 229 766242 13541 70148432
Muscle strain 18.49 10.38 159 766312 8551 70153422
Tonsillar ulcer 18.47 10.38 23 766448 406 70161567
Hepatic cancer 18.46 10.38 49 766422 9634 70152339
Hyperaesthesia teeth 18.40 10.38 49 766422 1599 70160374
Fibula fracture 18.40 10.38 77 766394 3186 70158787
Product prescribing error 18.31 10.38 551 765920 38401 70123572
Transaminases increased 18.30 10.38 378 766093 46640 70115333
Pharyngitis streptococcal 18.27 10.38 169 766302 9279 70152694
Diverticulum intestinal 18.25 10.38 149 766322 7892 70154081
Metastases to lung 18.17 10.38 104 766367 16380 70145593
Nervous system disorder 18.10 10.38 170 766301 23976 70137997
Blood iron decreased 18.05 10.38 221 766250 13040 70148933
Dehydration 17.96 10.38 2154 764317 223988 69937985
Liver disorder 17.93 10.38 517 765954 61051 70100922
Breast disorder 17.91 10.38 54 766417 1895 70160078
Blood urea increased 17.90 10.38 369 766102 45540 70116433
Neck mass 17.84 10.38 91 766380 4095 70157878
Obstructive airways disorder 17.84 10.38 188 766283 25925 70136048
Hyperprolactinaemia 17.79 10.38 13 766458 4400 70157573
Strongyloidiasis 17.76 10.38 9 766462 3714 70158259
Deep vein thrombosis 17.70 10.38 1000 765471 110042 70051931
Lower limb fracture 17.69 10.38 267 766204 16505 70145468
Systemic mycosis 17.63 10.38 3 766468 2519 70159454
Oral pain 17.62 10.38 425 766046 28641 70133332
Multiple sclerosis 17.60 10.38 377 766094 24908 70137065
Premature rupture of membranes 17.51 10.38 86 766385 3812 70158161
Spinal operation 17.47 10.38 133 766338 6895 70155078
Blood calcium increased 17.46 10.38 161 766310 8832 70153141
Invasive ductal breast carcinoma 17.40 10.38 115 766356 5694 70156279
Hypoglycaemic coma 17.38 10.38 13 766458 4348 70157625
Rotator cuff repair 17.35 10.38 48 766423 1603 70160370
Wheelchair user 17.33 10.38 106 766365 5108 70156865
Granulocytopenia 17.33 10.38 58 766413 10589 70151384
Schizophrenia 17.32 10.38 108 766363 16660 70145313
Prostate cancer 17.22 10.38 235 766236 30928 70131045
Arthritis infective 17.17 10.38 138 766333 7274 70154699
Tooth loss 17.14 10.38 124 766347 6326 70155647
Kidney transplant rejection 17.09 10.38 53 766418 9908 70152065
Amylase increased 17.03 10.38 55 766416 10153 70151820
Knee operation 17.03 10.38 103 766368 4944 70157029
Hernia 17.03 10.38 240 766231 14620 70147353
Musculoskeletal disorder 17.02 10.38 307 766164 19664 70142309
Shock haemorrhagic 17.00 10.38 120 766351 17986 70143987
Hyperuricaemia 17.00 10.38 61 766410 10905 70151068
Sinus bradycardia 16.99 10.38 168 766303 23455 70138518
Ligament sprain 16.99 10.38 201 766270 11762 70150211
Injection site warmth 16.95 10.38 226 766245 13599 70148374
Tooth infection 16.94 10.38 261 766210 16202 70145771
Blood lactate dehydrogenase increased 16.94 10.38 272 766199 34855 70127118
Ketoacidosis 16.93 10.38 33 766438 7236 70154737
Hypercalciuria 16.93 10.38 24 766447 483 70161490
Wrong product administered 16.90 10.38 41 766430 8310 70153663
Pancreatitis acute 16.89 10.38 366 766105 44858 70117115
Neuropathy peripheral 16.88 10.38 1162 765309 125734 70036239
Analgesic drug level increased 16.88 10.38 3 766468 2440 70159533
Ventricular hypokinesia 16.87 10.38 40 766431 8172 70153801
Hepatitis C 16.85 10.38 76 766395 12731 70149242
Pre-eclampsia 16.84 10.38 124 766347 6361 70155612
Endodontic procedure 16.83 10.38 63 766408 2474 70159499
Inadequate analgesia 16.81 10.38 12 766459 4110 70157863
Polyuria 16.78 10.38 81 766390 13325 70148648
Edentulous 16.69 10.38 17 766454 238 70161735
Metastases to lymph nodes 16.68 10.38 48 766423 9190 70152783
Circulatory collapse 16.68 10.38 276 766195 35198 70126775
Cardiac failure chronic 16.67 10.38 56 766415 10213 70151760
Hypertonic bladder 16.66 10.38 83 766388 3700 70158273
Osteoporotic fracture 16.65 10.38 83 766388 3701 70158272
Back disorder 16.59 10.38 181 766290 10383 70151590
Gastric cancer 16.56 10.38 46 766425 8909 70153064
Systemic candida 16.54 10.38 24 766447 5910 70156063
Ileal stenosis 16.49 10.38 56 766415 2095 70159878
Viral infection 16.45 10.38 537 765934 37854 70124119
Coronary artery bypass 16.44 10.38 24 766447 5896 70156077
Type I hypersensitivity 16.39 10.38 10 766461 3722 70158251
Tenosynovitis stenosans 16.38 10.38 59 766412 2274 70159699
Disturbance in social behaviour 16.37 10.38 12 766459 4055 70157918
Multimorbidity 16.22 10.38 38 766433 1143 70160830
Hepatic cytolysis 16.21 10.38 131 766340 19061 70142912
Generalised oedema 16.20 10.38 153 766318 21555 70140418
Drug eruption 16.13 10.38 315 766156 39181 70122792
Haemorrhage subcutaneous 16.05 10.38 15 766456 4494 70157479
Clavicle fracture 16.04 10.38 84 766387 3820 70158153
Atrioventricular block complete 16.00 10.38 97 766374 15066 70146907
Pseudomembranous colitis 15.96 10.38 19 766452 5092 70156881
Mucous stools 15.93 10.38 85 766386 3894 70158079
Pruritus 15.88 10.38 4083 762388 341477 69820496
Dry mouth 15.88 10.38 922 765549 69535 70092438
Lumbar spinal stenosis 15.87 10.38 99 766372 4804 70157169
Right ventricular failure 15.78 10.38 159 766312 22115 70139858
Nightmare 15.76 10.38 158 766313 21998 70139975
Pulse absent 15.76 10.38 50 766421 9280 70152693
Genital haemorrhage 15.74 10.38 24 766447 5791 70156182
Atrioventricular block 15.69 10.38 77 766394 12611 70149362
Mucosal inflammation 15.67 10.38 587 765884 67263 70094710
Jaundice cholestatic 15.66 10.38 49 766422 9135 70152838
Cellulitis 15.66 10.38 1257 765214 97671 70064302
Right atrial hypertrophy 15.65 10.38 26 766445 604 70161369
Road traffic accident 15.61 10.38 488 765983 34194 70127779
Milk-alkali syndrome 15.55 10.38 38 766433 1175 70160798
Hypomania 15.55 10.38 26 766445 6046 70155927
Disinhibition 15.52 10.38 3 766468 2298 70159675
Acute chest syndrome 15.52 10.38 33 766438 929 70161044
Cystic fibrosis 15.50 10.38 89 766382 4192 70157781
Bladder hypertrophy 15.38 10.38 25 766446 570 70161403
Oculogyric crisis 15.34 10.38 5 766466 2693 70159280
Uterine perforation 15.29 10.38 25 766446 5866 70156107
Arthropod bite 15.25 10.38 133 766338 7182 70154791
Groin pain 15.24 10.38 198 766273 11844 70150129
Inflammatory bowel disease 15.18 10.38 100 766371 4946 70157027
Intervertebral disc protrusion 15.10 10.38 321 766150 21182 70140791
Sudden death 15.07 10.38 150 766321 20914 70141059
Cardiopulmonary failure 15.02 10.38 29 766442 6381 70155592
Immunodeficiency 15.01 10.38 270 766201 17285 70144688
Ingrown hair 14.99 10.38 26 766445 626 70161347
Pseudomonas infection 14.99 10.38 132 766339 18862 70143111
Device leakage 14.95 10.38 51 766420 9257 70152716
Victim of child abuse 14.92 10.38 32 766439 906 70161067
Oral disorder 14.90 10.38 159 766312 9070 70152903
Large intestinal stenosis 14.86 10.38 61 766410 2502 70159471
Exostosis of jaw 14.82 10.38 37 766434 1160 70160813
Pneumonia bacterial 14.80 10.38 112 766359 16529 70145444
Hypophosphatasia 14.79 10.38 9 766462 55 70161918
Retinal haemorrhage 14.71 10.38 39 766432 7671 70154302
Periodontal disease 14.70 10.38 47 766424 1703 70160270
Body temperature decreased 14.69 10.38 410 766061 28262 70133711
Fistula 14.66 10.38 181 766290 10700 70151273
Finger deformity 14.63 10.38 115 766356 6021 70155952
Blepharospasm 14.62 10.38 81 766390 3764 70158209
Synovial disorder 14.62 10.38 35 766436 1068 70160905
Dyspepsia 14.61 10.38 1135 765336 87942 70074031
Cardiomyopathy 14.53 10.38 199 766272 26174 70135799
Isosthenuria 14.49 10.38 11 766460 101 70161872
Bacteraemia 14.45 10.38 226 766245 29083 70132890
Blood culture positive 14.45 10.38 41 766430 7885 70154088
Normal newborn 14.44 10.38 117 766354 6183 70155790
Subdural haematoma 14.42 10.38 226 766245 29072 70132901
Plantar fasciitis 14.42 10.38 70 766401 3088 70158885
Long QT syndrome 14.41 10.38 22 766449 5305 70156668
Osteomalacia 14.39 10.38 41 766430 1393 70160580
Skin laceration 14.39 10.38 374 766097 25504 70136469
Hepatitis acute 14.38 10.38 90 766381 13872 70148101
Urticaria 14.37 10.38 1542 764929 161507 70000466
Urge incontinence 14.34 10.38 34 766437 1031 70160942
Delusion 14.33 10.38 135 766336 19030 70142943
Osteomyelitis 14.29 10.38 429 766042 29889 70132084
Appendix disorder 14.27 10.38 44 766427 1563 70160410
Ulcer 14.26 10.38 372 766099 25382 70136591
Loose body in joint 14.22 10.38 38 766433 1243 70160730
Infection reactivation 14.21 10.38 4 766467 2369 70159604
Product dose omission in error 14.20 10.38 92 766379 4524 70157449
Nerve compression 14.20 10.38 143 766328 8035 70153938
Immune-mediated myositis 14.18 10.38 8 766463 3108 70158865
Influenza like illness 14.17 10.38 852 765619 64479 70097494
Hepatic necrosis 14.14 10.38 47 766424 8599 70153374
Linear IgA disease 14.05 10.38 7 766464 2917 70159056
Dyskinesia 14.05 10.38 337 766134 40737 70121236
Collagen-vascular disease 13.98 10.38 10 766461 83 70161890
Neutropenic colitis 13.95 10.38 21 766450 5093 70156880
Renal cyst haemorrhage 13.93 10.38 25 766446 619 70161354
Hypoxic-ischaemic encephalopathy 13.92 10.38 37 766434 7271 70154702
Myelodysplastic syndrome 13.91 10.38 232 766239 29553 70132420
Micturition urgency 13.89 10.38 185 766286 11129 70150844
Patellofemoral pain syndrome 13.85 10.38 21 766450 450 70161523
Disease recurrence 13.85 10.38 305 766166 37298 70124675
JC polyomavirus test positive 13.79 10.38 38 766433 1266 70160707
Klebsiella infection 13.77 10.38 94 766377 14198 70147775
Breast feeding 13.75 10.38 26 766445 671 70161302
Post procedural haemorrhage 13.74 10.38 82 766389 12784 70149189
Lip dry 13.72 10.38 164 766307 9621 70152352
Electrocardiogram ST segment depression 13.70 10.38 17 766454 4474 70157499
Compartment syndrome 13.66 10.38 17 766454 4469 70157504
Coronary artery stenosis 13.64 10.38 72 766399 11572 70150401
Secondary progressive multiple sclerosis 13.63 10.38 39 766432 1328 70160645
Periprosthetic fracture 13.61 10.38 24 766447 586 70161387
Urinary retention 13.59 10.38 448 766023 52072 70109901
Rash pruritic 13.57 10.38 821 765650 62170 70099803
Breast abscess 13.57 10.38 37 766434 1225 70160748
Apraxia 13.54 10.38 6 766465 2677 70159296
Kidney infection 13.52 10.38 290 766181 19165 70142808
Chondropathy 13.44 10.38 57 766414 2373 70159600
Colitis ulcerative 13.39 10.38 470 766001 33453 70128520
Rash morbilliform 13.38 10.38 24 766447 5431 70156542
Hyperparathyroidism secondary 13.38 10.38 59 766412 2499 70159474
Pelvic fracture 13.36 10.38 183 766288 11078 70150895
Injection site mass 13.26 10.38 275 766196 18068 70143905
Hypomagnesaemia 13.25 10.38 337 766134 40427 70121546
Anaphylactoid reaction 13.23 10.38 21 766450 4986 70156987
Abscess oral 13.23 10.38 38 766433 1297 70160676
Peripheral venous disease 13.22 10.38 175 766296 10512 70151461
Medication error 13.22 10.38 492 765979 56420 70105553
Candida infection 13.17 10.38 278 766193 34195 70127778
Homicidal ideation 13.13 10.38 10 766461 3313 70158660
Personality disorder 13.09 10.38 25 766446 5523 70156450
Bone metabolism disorder 13.07 10.38 21 766450 474 70161499
Prescribed underdose 13.06 10.38 313 766158 21072 70140901
Areflexia 13.05 10.38 22 766449 5100 70156873
Hepatitis 13.01 10.38 426 766045 49554 70112419
Rectocele 13.00 10.38 23 766448 563 70161410
Pulmonary hypertension 13.00 10.38 393 766078 46143 70115830
Distributive shock 12.98 10.38 4 766467 2233 70159740
Vascular pseudoaneurysm 12.95 10.38 10 766461 3291 70158682
Rash erythematous 12.95 10.38 443 766028 51275 70110698
Loose tooth 12.92 10.38 65 766406 2909 70159064
Bacterial sepsis 12.90 10.38 41 766430 7606 70154367
Spinal compression fracture 12.87 10.38 238 766233 15315 70146658
Pancreatic failure 12.87 10.38 41 766430 1483 70160490
Vitamin B complex deficiency 12.86 10.38 23 766448 568 70161405
Gastrointestinal infection 12.84 10.38 158 766313 9333 70152640
Anal fissure 12.82 10.38 113 766358 6120 70155853
Bacterial disease carrier 12.80 10.38 33 766438 1056 70160917
Ischaemic cardiomyopathy 12.76 10.38 37 766434 7067 70154906
Hypernatraemia 12.76 10.38 83 766388 12678 70149295
Hyperlactacidaemia 12.73 10.38 22 766449 5050 70156923
Colitis microscopic 12.73 10.38 52 766419 8953 70153020
Cholangitis 12.66 10.38 73 766398 11476 70150497
Autonomic nervous system imbalance 12.64 10.38 17 766454 4322 70157651
Impaired fasting glucose 12.64 10.38 18 766453 364 70161609
Metastases to bone 12.63 10.38 168 766303 22208 70139765
Migraine 12.61 10.38 925 765546 71313 70090660
CSF immunoglobulin increased 12.61 10.38 7 766464 35 70161938
Pollakiuria 12.57 10.38 461 766010 33000 70128973
Foetal distress syndrome 12.56 10.38 20 766451 448 70161525
Dairy intolerance 12.55 10.38 9 766462 75 70161898
Neurologic neglect syndrome 12.54 10.38 5 766466 2376 70159597
Chest pain 12.53 10.38 2459 764012 248801 69913172
Premature labour 12.53 10.38 137 766334 7863 70154110
Brain death 12.51 10.38 23 766448 5155 70156818
Incorrect route of product administration 12.49 10.38 206 766265 26286 70135687
Dialysis 12.42 10.38 124 766347 17278 70144695
Carotid artery thrombosis 12.38 10.38 6 766465 2540 70159433
Renal tubular acidosis 12.37 10.38 11 766460 3375 70158598
Pericardial effusion 12.37 10.38 350 766121 41426 70120547
Sinus disorder 12.35 10.38 280 766191 18679 70143294
Rib fracture 12.28 10.38 360 766111 24996 70136977
Acrochordon 12.27 10.38 30 766441 928 70161045
Extradural haematoma 12.23 10.38 7 766464 2698 70159275
Immune effector cell-associated neurotoxicity syndrome 12.20 10.38 15 766456 3963 70158010
Postpartum haemorrhage 12.17 10.38 40 766431 1471 70160502
Myocarditis 12.16 10.38 137 766334 18656 70143317
Gingival pain 12.14 10.38 119 766352 6638 70155335
Onychomycosis 12.14 10.38 121 766350 6780 70155193
Mean cell haemoglobin increased 12.11 10.38 73 766398 3500 70158473
Blood calcium abnormal 12.11 10.38 37 766434 1308 70160665
Hypersomnia 12.10 10.38 302 766169 20462 70141511
Hypogammaglobulinaemia 12.08 10.38 74 766397 11464 70150509
Synovial fluid analysis 12.06 10.38 46 766425 1823 70160150
Alcohol abuse 12.06 10.38 23 766448 5084 70156889
Maternal exposure timing unspecified 12.00 10.38 85 766386 4306 70157667
Faecal calprotectin increased 11.96 10.38 86 766385 4379 70157594
Taste disorder 11.91 10.38 181 766290 11204 70150769
Anger 11.91 10.38 114 766357 16018 70145955
Mitral valve prolapse 11.87 10.38 47 766424 1896 70160077
Obesity 11.87 10.38 376 766095 26395 70135578
Dry skin 11.86 10.38 728 765743 55203 70106770
Lacrimal disorder 11.84 10.38 20 766451 471 70161502
Skin ulcer 11.82 10.38 635 765836 47510 70114463
Sensitive skin 11.81 10.38 36 766435 1271 70160702
Lipodystrophy acquired 11.80 10.38 17 766454 4199 70157774
Soft tissue mass 11.80 10.38 32 766439 1056 70160917
Methaemoglobinaemia 11.79 10.38 21 766450 4765 70157208
Capillary leak syndrome 11.77 10.38 12 766459 3450 70158523
Gene mutation 11.76 10.38 5 766466 2286 70159687
Chest wall tumour 11.74 10.38 7 766464 41 70161932
Anticholinergic syndrome 11.73 10.38 9 766462 2971 70159002
Cartilage injury 11.71 10.38 38 766433 1388 70160585
Blood parathyroid hormone decreased 11.68 10.38 149 766322 8875 70153098
Enterococcal infection 11.66 10.38 101 766370 14481 70147492
Corneal oedema 11.65 10.38 6 766465 2454 70159519
Decreased immune responsiveness 11.61 10.38 92 766379 4829 70157144
Sleep disorder 11.58 10.38 891 765580 68981 70092992
Delivery 11.55 10.38 22 766449 571 70161402
Haematocrit decreased 11.54 10.38 742 765729 56516 70105457
Cerebral haematoma 11.46 10.38 41 766430 7337 70154636
Injury 11.43 10.38 582 765889 64663 70097310
Epicondylitis 11.43 10.38 47 766424 1929 70160044
Fracture displacement 11.43 10.38 34 766437 1184 70160789
Seasonal allergy 11.39 10.38 207 766264 13277 70148696
Pregnancy with contraceptive device 11.39 10.38 11 766460 3244 70158729
Pupillary reflex impaired 11.38 10.38 11 766460 3243 70158730
Nephritic syndrome 11.36 10.38 16 766455 320 70161653
Oedema 11.33 10.38 964 765507 102617 70059356
Iron metabolism disorder 11.29 10.38 6 766465 27 70161946
Necrotising fasciitis 11.29 10.38 27 766444 5499 70156474
Ingrowing nail 11.27 10.38 55 766416 2431 70159542
Fear of injection 11.26 10.38 116 766355 6556 70155417
SARS-CoV-2 antibody test positive 11.26 10.38 17 766454 363 70161610
Radiation pneumonitis 11.24 10.38 14 766457 3679 70158294
Therapy cessation 11.24 10.38 458 766013 33218 70128755
Liver transplant rejection 11.20 10.38 10 766461 3062 70158911
Blood 25-hydroxycholecalciferol decreased 11.18 10.38 16 766455 325 70161648
Cervical incompetence 11.18 10.38 20 766451 494 70161479
Central nervous system lesion 11.17 10.38 193 766278 12260 70149713
Uterine disorder 11.14 10.38 47 766424 1952 70160021
Vitamin B12 deficiency 11.14 10.38 106 766365 5866 70156107
Forced expiratory volume decreased 11.13 10.38 41 766430 7273 70154700
Adjustment disorder with depressed mood 11.11 10.38 81 766390 4142 70157831
Vaccination site reaction 11.10 10.38 10 766461 119 70161854
Priapism 11.09 10.38 17 766454 4093 70157880
Aortic arteriosclerosis 11.08 10.38 132 766339 7737 70154236
Iodine allergy 11.07 10.38 21 766450 543 70161430
Diabetes insipidus 11.06 10.38 21 766450 4650 70157323
Hungry bone syndrome 11.03 10.38 12 766459 182 70161791
Animal bite 11.03 10.38 53 766418 2328 70159645
Leukoencephalopathy 11.02 10.38 41 766430 7253 70154720
Salivary hypersecretion 11.02 10.38 88 766383 12837 70149136
Fluid retention 11.00 10.38 566 765905 62819 70099154
Dysstasia 10.99 10.38 353 766118 24826 70137147
Renal cyst 10.97 10.38 204 766267 13141 70148832
Tonsillitis 10.97 10.38 108 766363 6032 70155941
Haematuria 10.97 10.38 568 765903 63005 70098968
Diverticulitis 10.97 10.38 554 765917 41180 70120793
Congestive cardiomyopathy 10.96 10.38 71 766400 10855 70151118
Hepatic cyst 10.95 10.38 100 766371 5471 70156502
Polyneuropathy 10.95 10.38 164 766307 21251 70140722
Aphasia 10.94 10.38 370 766101 42879 70119094
Gastric ulcer haemorrhage 10.93 10.38 51 766420 8467 70153506
Phospholipidosis 10.90 10.38 10 766461 122 70161851
Nocturia 10.90 10.38 189 766282 12015 70149958
Parathyroid tumour benign 10.88 10.38 24 766447 693 70161280
Hallucination 10.87 10.38 694 765777 75566 70086407
Pneumonia fungal 10.86 10.38 63 766408 9890 70152083
Osteocalcin decreased 10.86 10.38 7 766464 48 70161925
Cyst removal 10.84 10.38 18 766453 418 70161555
Depressive symptom 10.83 10.38 25 766446 5156 70156817
Intestinal ischaemia 10.82 10.38 81 766390 11983 70149990
Blood creatine phosphokinase MB increased 10.80 10.38 8 766463 2689 70159284
Lip ulceration 10.80 10.38 48 766423 2040 70159933
Foetal death 10.79 10.38 109 766362 6130 70155843
Malignant mediastinal neoplasm 10.79 10.38 27 766444 848 70161125
Ischaemic stroke 10.78 10.38 252 766219 30568 70131405
Chronic myeloid leukaemia 10.75 10.38 18 766453 4183 70157790
Temporomandibular joint syndrome 10.74 10.38 71 766400 3516 70158457
Staphylococcal sepsis 10.73 10.38 93 766378 13334 70148639
Speech disorder 10.72 10.38 442 766029 50138 70111835
Cardiac tamponade 10.72 10.38 52 766419 8543 70153430
Anxiety 10.71 10.38 2159 764312 218171 69943802
Blood pH decreased 10.71 10.38 20 766451 4456 70157517
Diffuse large B-cell lymphoma 10.69 10.38 92 766379 13210 70148763
Cryptococcosis 10.66 10.38 12 766459 3298 70158675
Blood selenium decreased 10.62 10.38 3 766468 0 70161973
Genitourinary operation 10.62 10.38 3 766468 0 70161973
Retinal neoplasm 10.62 10.38 3 766468 0 70161973
Bone scan 10.62 10.38 3 766468 0 70161973
Micrographic skin surgery 10.62 10.38 3 766468 0 70161973
Complications of transplanted kidney 10.59 10.38 31 766440 5903 70156070
Hypervitaminosis D 10.55 10.38 9 766462 99 70161874
Oral mucosal blistering 10.55 10.38 99 766372 5457 70156516
Blood iron increased 10.55 10.38 37 766434 1407 70160566
Atrophic vulvovaginitis 10.54 10.38 33 766438 1182 70160791
Menopause 10.52 10.38 43 766428 1760 70160213
Quadriparesis 10.49 10.38 11 766460 3122 70158851
Flatulence 10.48 10.38 509 765962 37672 70124301
Gingivitis 10.48 10.38 136 766335 8134 70153839
Vertebral wedging 10.47 10.38 5 766466 17 70161956
Clostridium difficile colitis 10.45 10.38 236 766235 28760 70133213
Urine odour abnormal 10.44 10.38 100 766371 5543 70156430
Umbilical hernia 10.44 10.38 94 766377 5122 70156851
Tumour haemorrhage 10.43 10.38 15 766456 3707 70158266

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A11CC05 ALIMENTARY TRACT AND METABOLISM
VITAMINS
VITAMIN A AND D, INCL. COMBINATIONS OF THE TWO
Vitamin D and analogues
ATC A11CC55 ALIMENTARY TRACT AND METABOLISM
VITAMINS
VITAMIN A AND D, INCL. COMBINATIONS OF THE TWO
Vitamin D and analogues
ATC M05BB03 MUSCULO-SKELETAL SYSTEM
DRUGS FOR TREATMENT OF BONE DISEASES
DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION
Bisphosphonates, combinations
ATC M05BB04 MUSCULO-SKELETAL SYSTEM
DRUGS FOR TREATMENT OF BONE DISEASES
DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION
Bisphosphonates, combinations
ATC M05BB05 MUSCULO-SKELETAL SYSTEM
DRUGS FOR TREATMENT OF BONE DISEASES
DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION
Bisphosphonates, combinations
ATC M05BB07 MUSCULO-SKELETAL SYSTEM
DRUGS FOR TREATMENT OF BONE DISEASES
DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION
Bisphosphonates, combinations
ATC M05BB08 MUSCULO-SKELETAL SYSTEM
DRUGS FOR TREATMENT OF BONE DISEASES
DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION
Bisphosphonates, combinations
ATC M05BB09 MUSCULO-SKELETAL SYSTEM
DRUGS FOR TREATMENT OF BONE DISEASES
DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION
Bisphosphonates, combinations
ATC M05BX53 MUSCULO-SKELETAL SYSTEM
DRUGS FOR TREATMENT OF BONE DISEASES
DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION
Other drugs affecting bone structure and mineralization
FDA CS M0022797 Vitamin D
MeSH PA D050071 Bone Density Conservation Agents
MeSH PA D000077264 Calcium-Regulating Hormones and Agents
MeSH PA D018977 Micronutrients
MeSH PA D014815 Vitamins
FDA EPC N0000175952 Vitamin D
CHEBI has role CHEBI:77746 Homo sapiens metabolite
CHEBI has role CHEBI:176497 geroprotectors

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Osteomalacia indication 4598005 DOID:10573
Hypocalcemia indication 5291005
Vitamin D deficiency indication 34713006
Hypoparathyroidism indication 36976004 DOID:11199
Rickets indication 41345002 DOID:10609
Osteoporosis indication 64859006 DOID:11476
Vitamin deficiency indication 85670002
Postmenopausal osteoporosis indication 102447009
Prevention of dental caries indication 426482000
Glucocorticoid Induced Osteoporosis indication
Hypogonadal Osteoporosis in Males indication
Vitamin D Dependent Rickets indication
Renal osteodystrophy off-label use 16726004 DOID:13068
Anticonvulsant-induced Osteomalacia off-label use
Gastritis contraindication 4556007 DOID:4029
Poisoning by digitalis glycoside contraindication 12876009
Constipation contraindication 14760008 DOID:2089
Esophagitis contraindication 16761005 DOID:11963
Primary hyperoxaluria contraindication 17901006 DOID:2977
Hyperphosphatemia contraindication 20165001 DOID:0050459
Hypervitaminosis D contraindication 27712000 DOID:9971
Dental fluorosis contraindication 30265004
Ulcer of esophagus contraindication 30811009
Sarcoidosis contraindication 31541009 DOID:11335
Dehydration contraindication 34095006
Hypertensive disorder contraindication 38341003 DOID:10763
Dysphagia contraindication 40739000
Achalasia of esophagus contraindication 45564002 DOID:9164
Atrial fibrillation contraindication 49436004 DOID:0060224
Vitamin E deficiency contraindication 54137008
Hyperlipidemia contraindication 55822004 DOID:1168
Joint pain contraindication 57676002
Acute nephropathy contraindication 58574008
Diarrhea contraindication 62315008
Stricture of esophagus contraindication 63305008
Hypervitaminosis A contraindication 64559002 DOID:9972
Blood coagulation disorder contraindication 64779008 DOID:1247
Hypercalcemia contraindication 66931009 DOID:12678
Hyperparathyroidism contraindication 66999008 DOID:13543
Fracture of femur contraindication 71620000
Hypercalciuria contraindication 71938000
Duodenitis contraindication 72007001 DOID:8643
Diabetes mellitus contraindication 73211009 DOID:9351
Kidney disease contraindication 90708001 DOID:557
Kidney stone contraindication 95570007
Anemia due to enzyme deficiency contraindication 111577008
Neoplasm of endometrium contraindication 123844007 DOID:1380
Neoplasm of prostate contraindication 126906006 DOID:10283
Hb SS disease contraindication 127040003 DOID:10923
Bed-ridden contraindication 160685001
Acute peptic ulcer contraindication 196682000
Osteolysis contraindication 203522001
Disease of liver contraindication 235856003 DOID:409
Esophageal dysmotility contraindication 266434009 DOID:9192
Arteriosclerosis obliterans contraindication 361133006 DOID:5160
Malignant tumor of cervix contraindication 363354003 DOID:4362
Hemochromatosis contraindication 399187006 DOID:2352
Central nervous system depression contraindication 418072004
Aseptic necrosis of bone of jaw contraindication 441809006
Carcinoma of female breast contraindication 447782002
Vitamin K Deficiency Induced Hypoprothrombinemia contraindication
Malabsorption States contraindication
High Grade Dysplasia associated with Barrett's Esophagus contraindication
Esophageal Obstruction contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Vitamin D3 receptor Nuclear hormone receptor AGONIST EC50 9.68 CHEMBL CHEMBL
Glycine receptor subunit alpha-1 Ion channel EC50 6.40 CHEMBL
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial Enzyme WOMBAT-PK
Vitamin D 25-hydroxylase Enzyme WOMBAT-PK
Sterol 26-hydroxylase, mitochondrial Enzyme WOMBAT-PK
Vitamin D3 receptor Nuclear hormone receptor EC50 6.05 CHEMBL

External reference:

IDSource
D00188 KEGG_DRUG
4017667 VANDF
C0008318 UMLSCUI
CHEBI:28940 CHEBI
VD3 PDB_CHEM_ID
CHEMBL1042 ChEMBL_ID
DB00169 DRUGBANK_ID
2747 IUPHAR_LIGAND_ID
5280795 PUBCHEM_CID
1244014 RXNORM
15676 MMSL
199274 MMSL
4434 MMSL
4868 MMSL
4871 MMSL
d03129 MMSL
001014 NDDF
108943009 SNOMEDCT_US
18414002 SNOMEDCT_US
D002762 MESH_DESCRIPTOR_UI
1497 INN_ID
1C6V77QF41 UNII

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
FOSAMAX PLUS D HUMAN PRESCRIPTION DRUG LABEL 2 0006-0270 TABLET 5600 [iU] ORAL NDA 27 sections
FOSAMAX PLUS D HUMAN PRESCRIPTION DRUG LABEL 2 0006-0710 TABLET 2800 [iU] ORAL NDA 27 sections
NataFort HUMAN PRESCRIPTION DRUG LABEL 10 0178-0716 TABLET 400 [iU] ORAL Unapproved drug other 12 sections
CitraNatal Harmony 3.0 HUMAN PRESCRIPTION DRUG LABEL 8 0178-0796 CAPSULE, GELATIN COATED 400 [iU] ORAL unapproved drug other 10 sections
CitraNatal Harmony 3.0 HUMAN PRESCRIPTION DRUG LABEL 8 0178-0796 CAPSULE, GELATIN COATED 400 [iU] ORAL unapproved drug other 10 sections
CitraNatal Harmony HUMAN PRESCRIPTION DRUG LABEL 8 0178-0798 CAPSULE, GELATIN COATED 400 [iU] ORAL UNAPPROVED DRUG OTHER 11 sections
CitraNatal Harmony HUMAN PRESCRIPTION DRUG LABEL 8 0178-0799 CAPSULE, GELATIN COATED 400 [iU] ORAL Unapproved drug other 11 sections
CitraNatal Harmony HUMAN PRESCRIPTION DRUG LABEL 8 0178-0812 CAPSULE, GELATIN COATED 400 [iU] ORAL Unapproved drug other 11 sections
CitraNatal Medley HUMAN PRESCRIPTION DRUG LABEL 8 0178-0896 CAPSULE, GELATIN COATED 200 [iU] ORAL unapproved drug other 10 sections
Select OB HUMAN PRESCRIPTION DRUG LABEL 15 0642-0077 TABLET, CHEWABLE 400 [iU] ORAL UNAPPROVED DRUG OTHER 14 sections
Vitafol Ultra HUMAN PRESCRIPTION DRUG LABEL 17 0642-0093 CAPSULE, LIQUID FILLED 25 ug ORAL UNAPPROVED DRUG OTHER 13 sections
Vitafol Nano HUMAN PRESCRIPTION DRUG LABEL 7 0642-0094 TABLET, COATED 25 ug ORAL UNAPPROVED DRUG OTHER 14 sections
Select OB HUMAN PRESCRIPTION DRUG LABEL 15 0642-0120 TABLET, CHEWABLE 400 [iU] ORAL UNAPPROVED DRUG OTHER 13 sections
Strovite One Caplets HUMAN PRESCRIPTION DRUG LABEL 20 0642-0207 TABLET 25 ug ORAL UNAPPROVED DRUG OTHER 14 sections
Vitafol HUMAN PRESCRIPTION DRUG LABEL 4 0642-7468 STRIP 1000 [iU] ORAL Unapproved drug other 13 sections
Vitafol Fe Plus HUMAN PRESCRIPTION DRUG LABEL 17 0642-7473 CAPSULE, LIQUID FILLED 25 mg ORAL UNAPPROVED DRUG OTHER 14 sections
Marnatal F HUMAN PRESCRIPTION DRUG LABEL 13 0682-1570 CAPSULE 400 [iU] ORAL UNAPPROVED DRUG OTHER 4 sections
O-Cal Prenatal Vitamin HUMAN PRESCRIPTION DRUG LABEL 16 0813-0202 TABLET 400 [iU] ORAL UNAPPROVED DRUG OTHER 6 sections
Dialyvite Supreme D HUMAN PRESCRIPTION DRUG LABEL 13 10542-009 TABLET, COATED 2000 [iU] ORAL Unapproved drug other 7 sections
Dialyvite Supreme D HUMAN PRESCRIPTION DRUG LABEL 13 10542-009 TABLET, COATED 2000 [iU] ORAL Unapproved drug other 7 sections
PRENATAL PLUS HUMAN PRESCRIPTION DRUG LABEL 15 10544-549 TABLET, FILM COATED 400 [iU] ORAL unapproved drug other 8 sections
PRENATAL PLUS IRON HUMAN PRESCRIPTION DRUG LABEL 15 10544-609 TABLET, FILM COATED 400 [iU] ORAL UNAPPROVED DRUG OTHER 7 sections
Se-Natal 19 HUMAN PRESCRIPTION DRUG LABEL 15 13925-116 TABLET 400 [iU] ORAL unapproved drug other 15 sections
Se-Natal 19 HUMAN PRESCRIPTION DRUG LABEL 15 13925-116 TABLET 400 [iU] ORAL unapproved drug other 15 sections
Se-Natal 19 Chewable HUMAN PRESCRIPTION DRUG LABEL 14 13925-117 TABLET, CHEWABLE 400 [iU] ORAL unapproved drug other 16 sections
PRENATAL PLUS HUMAN PRESCRIPTION DRUG LABEL 15 15338-522 TABLET, FILM COATED 400 [iU] ORAL unapproved drug other 8 sections
Quflora Pediatric Drops HUMAN PRESCRIPTION DRUG LABEL 13 15370-100 LIQUID 400 [iU] ORAL UNAPPROVED DRUG OTHER 11 sections
Quflora Pediatric Drops HUMAN PRESCRIPTION DRUG LABEL 13 15370-101 LIQUID 400 [iU] ORAL UNAPPROVED DRUG OTHER 11 sections
Quflora FE Pediatric Drops HUMAN PRESCRIPTION DRUG LABEL 14 15370-102 LIQUID 400 [iU] ORAL UNAPPROVED DRUG OTHER 11 sections
Quflora Pediatric HUMAN PRESCRIPTION DRUG LABEL 14 15370-103 TABLET, CHEWABLE 400 [iU] ORAL UNAPPROVED DRUG OTHER 12 sections