colecalciferol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
Vitamin D analogues/derivatives 2840 67-97-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • Vitamin D3
  • cholecalciferol
  • arachitol
  • calciol
  • calcirol
  • colecalciferol
Derivative of 7-dehydroxycholesterol formed by ULTRAVIOLET RAYS breaking of the C9-C10 bond. It differs from ERGOCALCIFEROL in having a single bond between C22 and C23 and lacking a methyl group at C24. Some experts recommend maintaining recommended levels of vitamin D intake during the COVID-19 pandemic to maintain bone and muscle health and avoid deficiency. Efficacy of vitamin D supplementation in the prevention or treatment of COVID-19 has not been established.
  • Molecular weight: 384.65
  • Formula: C27H44O
  • CLOGP: 9.48
  • LIPINSKI: 1
  • HAC: 1
  • HDO: 1
  • TPSA: 20.23
  • ALOGS: -6.01
  • ROTB: 6
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
20 mcg O
10 mg O
5 mg O
10 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.10 mg/mL Benet LZ, Broccatelli F, Oprea TI

Approvals:

DateAgencyCompanyOrphan
May 18, 2000 FDA SANDOZ

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 1485.47 11.32 120 844216 145553 62499133
Toxicity to various agents 1352.58 11.32 806 843530 246444 62398242
Pemphigus 644.52 11.32 4418 839918 179308 62465378
Systemic lupus erythematosus 616.22 11.32 4820 839516 204098 62440588
Drug abuse 596.84 11.32 119 844217 72399 62572287
Death 572.96 11.32 2795 841541 371586 62273100
Intentional overdose 563.59 11.32 145 844191 74007 62570679
Glossodynia 529.58 11.32 4131 840205 174745 62469941
Alopecia 475.99 11.32 6702 837634 330834 62313852
Drug interaction 450.10 11.32 1551 842785 227580 62417106
Abdominal discomfort 438.59 11.32 6337 837999 314548 62330138
Arthropathy 411.73 11.32 4854 839482 229938 62414748
Overdose 404.96 11.32 563 843773 114515 62530171
Hand deformity 386.58 11.32 3522 840814 155935 62488751
Suicide attempt 359.61 11.32 180 844156 60738 62583948
Wound 349.68 11.32 3513 840823 159750 62484936
Cardiac arrest 342.67 11.32 436 843900 92109 62552577
Depressed level of consciousness 340.84 11.32 201 844135 61877 62582809
Rheumatoid arthritis 338.77 11.32 4993 839343 248826 62395860
Pain 320.57 11.32 12450 831886 728178 61916508
Drug hypersensitivity 320.11 11.32 2619 841717 308068 62336618
Febrile neutropenia 278.09 11.32 738 843598 117711 62526975
Maternal exposure during pregnancy 266.99 11.32 4260 840076 215802 62428884
Femur fracture 252.26 11.32 1163 843173 40593 62604093
Fatigue 249.35 11.32 14299 830037 873729 61770957
Joint swelling 230.98 11.32 5847 838489 321819 62322867
Cardio-respiratory arrest 227.67 11.32 277 844059 59682 62585004
Arthralgia 222.31 11.32 9475 834861 560235 62084451
Malignant neoplasm progression 221.88 11.32 475 843861 81646 62563040
Discomfort 221.67 11.32 3289 841047 164085 62480601
Anti-cyclic citrullinated peptide antibody positive 217.92 11.32 2435 841901 113777 62530909
Coma 212.55 11.32 329 844007 64035 62580651
Pericarditis 211.10 11.32 2676 841660 128903 62515783
Sedation 205.59 11.32 131 844205 38678 62606008
Swelling 200.81 11.32 4937 839399 270441 62374245
Respiratory arrest 193.35 11.32 96 844240 32549 62612137
Hypotension 187.75 11.32 2525 841811 270079 62374607
Synovitis 182.97 11.32 3497 840839 183421 62461265
Infusion related reaction 179.63 11.32 4404 839932 241117 62403569
Acute kidney injury 168.56 11.32 2476 841860 260939 62383747
Hepatic function abnormal 166.45 11.32 149 844187 36993 62607693
Lactic acidosis 159.45 11.32 164 844172 38123 62606563
Disease progression 156.79 11.32 972 843364 121786 62522900
Psoriatic arthropathy 156.52 11.32 1884 842452 89636 62555050
Drug reaction with eosinophilia and systemic symptoms 152.51 11.32 135 844201 33701 62610985
Contraindicated product administered 146.18 11.32 3860 840476 213788 62430898
Osteoarthritis 146.10 11.32 1923 842413 93420 62551266
Product use issue 144.40 11.32 3898 840438 216622 62428064
Serotonin syndrome 143.64 11.32 103 844233 28579 62616107
Drug resistance 141.09 11.32 64 844272 22869 62621817
Agitation 138.17 11.32 375 843961 59382 62585304
Low turnover osteopathy 138.05 11.32 220 844116 3965 62640721
Psoriasis 137.91 11.32 1765 842571 85192 62559494
Intentional self-injury 137.03 11.32 86 844250 25601 62619085
Renal failure 134.94 11.32 962 843374 116690 62527996
Neutropenia 134.20 11.32 1584 842752 173421 62471265
Nasopharyngitis 128.44 11.32 4353 839983 249904 62394782
Musculoskeletal stiffness 128.23 11.32 3289 841047 181329 62463357
Cardiac failure 127.13 11.32 681 843655 88461 62556225
Multiple organ dysfunction syndrome 126.13 11.32 363 843973 56389 62588297
Metabolic acidosis 123.12 11.32 259 844077 44810 62599876
Anaphylactic reaction 120.61 11.32 461 843875 65639 62579047
Rhabdomyolysis 120.55 11.32 252 844084 43699 62600987
Duodenal ulcer perforation 119.79 11.32 1725 842611 85484 62559202
Helicobacter infection 118.73 11.32 1813 842523 90972 62553714
Rheumatoid factor positive 117.70 11.32 1674 842662 82732 62561954
Somnolence 116.50 11.32 1673 842663 177012 62467674
Hepatic failure 115.11 11.32 185 844151 35471 62609215
Bradycardia 114.94 11.32 541 843795 72686 62572000
Knee arthroplasty 108.56 11.32 1151 843185 53055 62591631
Thrombocytopenia 108.36 11.32 1388 842948 149769 62494917
Myelosuppression 105.12 11.32 96 844240 23607 62621079
Sedation complication 105.04 11.32 27 844309 13795 62630891
Altered state of consciousness 104.01 11.32 109 844227 25121 62619565
Myocardial infarction 103.11 11.32 841 843495 99052 62545634
Intramedullary rod insertion 101.37 11.32 133 844203 1990 62642696
Device expulsion 101.12 11.32 194 844142 34728 62609958
Sickle cell anaemia with crisis 97.49 11.32 234 844102 5769 62638917
Shock 97.13 11.32 101 844235 23362 62621324
Hip arthroplasty 96.96 11.32 1015 843321 46631 62598055
Sinusitis 96.52 11.32 3807 840529 222846 62421840
Creatinine renal clearance decreased 96.51 11.32 48 844288 16260 62628426
Respiratory failure 96.46 11.32 877 843459 100981 62543705
Poisoning 96.31 11.32 31 844305 13669 62631017
Drug ineffective for unapproved indication 96.23 11.32 192 844144 33871 62610815
Tachycardia 95.41 11.32 1057 843279 117099 62527587
Impaired healing 93.35 11.32 1898 842438 100644 62544042
Seizure 92.82 11.32 1224 843112 131410 62513276
Electrocardiogram QT prolonged 92.72 11.32 441 843895 59089 62585597
Mydriasis 91.54 11.32 23 844313 11933 62632753
Cytomegalovirus infection 86.95 11.32 90 844246 20862 62623824
Hepatotoxicity 86.71 11.32 231 844105 36810 62607876
Vitamin D deficiency 86.16 11.32 390 843946 13502 62631184
Cardiac failure congestive 84.44 11.32 803 843533 91630 62553056
Drug dependence 83.86 11.32 122 844214 24361 62620325
Respiratory depression 83.25 11.32 39 844297 13676 62631010
Dyspnoea 83.03 11.32 7620 836716 653693 61990993
Peripheral swelling 82.33 11.32 4325 840011 261617 62383069
No adverse event 81.32 11.32 280 844056 41125 62603561
Hepatic enzyme increased 80.72 11.32 3375 840961 198953 62445733
Ventricular tachycardia 80.48 11.32 88 844248 19891 62624795
Red blood cell sedimentation rate abnormal 76.63 11.32 488 843848 19294 62625392
Hypoglycaemia 76.44 11.32 476 843860 59589 62585097
Sopor 75.37 11.32 111 844225 22053 62622633
Anaphylactic shock 73.15 11.32 126 844210 23507 62621179
Intentional product misuse 72.82 11.32 492 843844 60425 62584261
Orthostatic hypotension 72.74 11.32 242 844094 35918 62608768
Pain in extremity 72.43 11.32 5229 839107 326257 62318429
Hyperkalaemia 72.42 11.32 423 843913 53780 62590906
Vomiting 71.78 11.32 6437 837899 553180 62091506
Acute hepatic failure 71.34 11.32 83 844253 18244 62626442
Tooth disorder 70.18 11.32 626 843710 27531 62617155
Drug withdrawal syndrome 69.58 11.32 162 844174 27032 62617654
Osteoporosis 69.38 11.32 1110 843226 56228 62588458
Hyperhidrosis 69.07 11.32 1013 843323 106823 62537863
Blood creatine phosphokinase increased 68.81 11.32 193 844143 30237 62614449
Neuroleptic malignant syndrome 67.63 11.32 38 844298 12018 62632668
Angioedema 67.50 11.32 368 843968 47597 62597089
Encephalopathy 66.85 11.32 275 844061 38345 62606341
Loss of consciousness 65.82 11.32 1139 843197 116982 62527704
Torsade de pointes 65.48 11.32 49 844287 13302 62631384
Extrapyramidal disorder 64.83 11.32 49 844287 13235 62631451
Blood cholesterol increased 64.57 11.32 1673 842663 92359 62552327
Mental status changes 63.64 11.32 290 844046 39309 62605377
Unresponsive to stimuli 63.53 11.32 233 844103 33583 62611103
Foot fracture 63.42 11.32 539 843797 23375 62621311
Disseminated intravascular coagulation 63.24 11.32 97 844239 18954 62625732
Product quality issue 62.95 11.32 254 844082 35611 62609075
Arthritis 62.89 11.32 2002 842334 113919 62530767
Spinal osteoarthritis 62.51 11.32 399 843937 15787 62628899
Palmar-plantar erythrodysaesthesia syndrome 62.24 11.32 133 844203 22882 62621804
Open reduction of fracture 62.12 11.32 77 844259 1085 62643601
Accidental exposure to product 61.83 11.32 174 844162 27231 62617455
Posterior reversible encephalopathy syndrome 61.83 11.32 84 844252 17261 62627425
Ventricular fibrillation 61.56 11.32 41 844295 11826 62632860
International normalised ratio increased 61.12 11.32 364 843972 46061 62598625
Product use in unapproved indication 60.49 11.32 1866 842470 177214 62467472
Cognitive disorder 60.32 11.32 464 843872 55351 62589335
Syncope 59.42 11.32 1151 843185 116234 62528452
Psychotic disorder 58.20 11.32 163 844173 25549 62619137
Emotional distress 58.09 11.32 229 844107 32320 62612366
Ejection fraction decreased 57.97 11.32 132 844204 22200 62622486
Hypomania 57.36 11.32 8 844328 6322 62638364
Hyponatraemia 57.32 11.32 1095 843241 110805 62533881
Fracture delayed union 57.32 11.32 110 844226 2312 62642374
Unintentional medical device removal 57.16 11.32 7 844329 6108 62638578
Coagulopathy 55.32 11.32 119 844217 20425 62624261
Fracture nonunion 55.26 11.32 105 844231 2190 62642496
Basal cell carcinoma 54.93 11.32 592 843744 27399 62617287
Acute respiratory distress syndrome 54.91 11.32 147 844189 23387 62621299
Infective pulmonary exacerbation of cystic fibrosis 54.29 11.32 247 844089 8570 62636116
COVID-19 53.66 11.32 1923 842413 111180 62533506
Cardiogenic shock 53.34 11.32 98 844238 17834 62626852
Akathisia 52.51 11.32 28 844308 9118 62635568
Status epilepticus 52.08 11.32 76 844260 15157 62629529
Device difficult to use 51.94 11.32 56 844280 12740 62631946
Acute generalised exanthematous pustulosis 51.58 11.32 43 844293 11056 62633630
Alanine aminotransferase increased 51.46 11.32 1021 843315 102749 62541937
Intervertebral disc degeneration 51.33 11.32 372 843964 15360 62629326
Dystonia 51.23 11.32 65 844271 13754 62630932
Stress fracture 51.23 11.32 226 844110 7737 62636949
Aspartate aminotransferase increased 51.10 11.32 868 843468 89409 62555277
Joint effusion 50.91 11.32 395 843941 16665 62628021
Wrong technique in product usage process 50.57 11.32 557 843779 61783 62582903
Hepatocellular injury 50.56 11.32 190 844146 27191 62617495
Metastases to liver 50.49 11.32 154 844182 23485 62621201
Brain oedema 50.34 11.32 69 844267 14126 62630560
Drug ineffective 50.31 11.32 12738 831598 1032027 61612659
Body height decreased 49.69 11.32 265 844071 9813 62634873
Sepsis 49.66 11.32 1604 842732 151519 62493167
Foot deformity 49.62 11.32 578 843758 27275 62617411
Neurotoxicity 49.52 11.32 94 844242 16896 62627790
Pyrexia 49.39 11.32 5490 838846 464988 62179698
Rheumatic fever 49.33 11.32 827 843509 42284 62602402
Venoocclusive liver disease 49.19 11.32 4 844332 4831 62639855
Thrombotic microangiopathy 48.97 11.32 41 844295 10520 62634166
Stevens-Johnson syndrome 48.81 11.32 169 844167 24781 62619905
Fall 48.42 11.32 5942 838394 386392 62258294
Metastases to central nervous system 48.21 11.32 62 844274 13043 62631643
Suicidal ideation 48.17 11.32 564 843772 61857 62582829
Ascites 48.15 11.32 330 844006 40398 62604288
Miosis 47.66 11.32 19 844317 7334 62637352
Septic shock 47.64 11.32 612 843724 66017 62578669
Spinal fracture 47.50 11.32 410 843926 17861 62626825
Hypoxia 47.41 11.32 537 843799 59255 62585431
Transplant rejection 47.40 11.32 44 844292 10736 62633950
Cerebral infarction 47.31 11.32 161 844175 23732 62620954
Bone marrow failure 46.77 11.32 215 844121 29075 62615611
Lower respiratory tract infection 46.33 11.32 2178 842158 130129 62514557
Device use error 46.26 11.32 10 844326 5751 62638935
Metastases to bone 45.56 11.32 136 844200 20883 62623803
Pulmonary oedema 45.02 11.32 489 843847 54384 62590302
Gamma-glutamyltransferase increased 44.70 11.32 267 844069 33764 62610922
Therapeutic product effect decreased 44.65 11.32 3062 841274 190125 62454561
Anaemia 44.54 11.32 3329 841007 290101 62354585
Toxic skin eruption 44.33 11.32 64 844272 12821 62631865
Dysarthria 44.32 11.32 359 843977 42352 62602334
Vitamin D decreased 44.31 11.32 260 844076 9982 62634704
Swollen joint count increased 44.00 11.32 699 843637 35355 62609331
Anaemia postoperative 43.75 11.32 94 844242 2148 62642538
Blood alkaline phosphatase increased 42.84 11.32 365 843971 42602 62602084
Aggression 42.78 11.32 164 844172 23334 62621352
Haematotoxicity 42.74 11.32 37 844299 9339 62635347
Nausea 42.53 11.32 10401 833935 844070 61800616
Blood bilirubin increased 42.40 11.32 304 844032 36836 62607850
Gastrointestinal haemorrhage 42.29 11.32 792 843544 80384 62564302
Face oedema 42.23 11.32 133 844203 20079 62624607
Inappropriate antidiuretic hormone secretion 42.11 11.32 89 844247 15373 62629313
Disorientation 41.68 11.32 330 844006 39122 62605564
Acute graft versus host disease 41.56 11.32 5 844331 4423 62640263
Cardiotoxicity 41.34 11.32 31 844305 8407 62636279
Obstructive airways disorder 41.31 11.32 139 844197 20560 62624126
Renal impairment 41.23 11.32 878 843458 87477 62557209
Bronchospasm 41.02 11.32 107 844229 17173 62627513
Injection site reaction 40.97 11.32 1044 843292 57480 62587206
Hyperglycaemia 40.70 11.32 358 843978 41509 62603177
Exposure to toxic agent 40.43 11.32 12 844324 5575 62639111
Platelet count decreased 40.17 11.32 1206 843130 114916 62529770
Tooth fracture 39.94 11.32 269 844067 10841 62633845
Urinary tract infection 39.91 11.32 4062 840274 260622 62384064
Graft versus host disease 39.88 11.32 20 844316 6743 62637943
Schizoaffective disorder 39.85 11.32 121 844215 3441 62641245
Thoracic vertebral fracture 39.74 11.32 143 844193 4449 62640237
Hypokalaemia 39.74 11.32 1063 843273 102741 62541945
Temperature regulation disorder 39.49 11.32 16 844320 6116 62638570
Night sweats 39.08 11.32 887 843449 47927 62596759
Contusion 38.78 11.32 2401 841935 147643 62497043
Restlessness 38.73 11.32 231 844105 29222 62615464
Abnormal behaviour 38.71 11.32 150 844186 21276 62623410
Injection site pruritus 38.40 11.32 827 843509 44289 62600397
Exposure during pregnancy 38.36 11.32 2479 841857 153068 62491618
Blood glucose increased 38.30 11.32 835 843501 82921 62561765
Leukopenia 38.15 11.32 761 843575 76529 62568157
Interstitial lung disease 38.10 11.32 586 843750 61322 62583364
Tremor 38.06 11.32 1406 842930 130833 62513853
Atypical femur fracture 38.06 11.32 157 844179 5215 62639471
Myoclonus 37.87 11.32 98 844238 15770 62628916
Anuria 37.86 11.32 68 844268 12483 62632203
Acute myeloid leukaemia 37.85 11.32 110 844226 17037 62627649
Neutrophil count decreased 37.82 11.32 525 843811 55881 62588805
Osteopenia 37.69 11.32 416 843920 19369 62625317
Mucosal inflammation 37.38 11.32 421 843915 46507 62598179
Substance abuse 37.29 11.32 9 844327 4798 62639888
Bone loss 37.26 11.32 108 844228 2991 62641695
Pulmonary embolism 36.94 11.32 1226 843110 115458 62529228
Asphyxia 36.87 11.32 18 844318 6163 62638523
Blood pressure decreased 36.85 11.32 625 843711 64397 62580289
Product dose omission issue 36.63 11.32 3605 840731 230708 62413978
Bone density decreased 36.48 11.32 325 844011 14287 62630399
Juvenile idiopathic arthritis 36.29 11.32 112 844224 3214 62641472
Fracture 36.05 11.32 409 843927 19175 62625511
Multiple-drug resistance 35.81 11.32 12 844324 5158 62639528
Bone giant cell tumour 34.92 11.32 14 844322 19 62644667
Bronchopulmonary aspergillosis 34.82 11.32 38 844298 8597 62636089
Pancreatitis 34.54 11.32 452 843884 48603 62596083
Cytokine release syndrome 34.47 11.32 88 844248 14226 62630460
Stress cardiomyopathy 34.46 11.32 45 844291 9405 62635281
Lower respiratory tract infection viral 34.00 11.32 51 844285 870 62643816
Accidental overdose 33.81 11.32 177 844159 23132 62621554
Asthma 33.70 11.32 1370 842966 126191 62518495
Sinus tachycardia 33.70 11.32 187 844149 24081 62620605
Systemic infection 33.66 11.32 137 844199 4523 62640163
Synovial cyst 33.63 11.32 246 844090 10187 62634499
Respiratory distress 33.58 11.32 289 844047 33662 62611024
Disability assessment scale score increased 33.55 11.32 107 844229 3126 62641560
Haemophagocytic lymphohistiocytosis 33.49 11.32 56 844280 10571 62634115
Pathogen resistance 33.33 11.32 22 844314 6376 62638310
Delirium 33.32 11.32 472 843864 50069 62594617
Cerebrovascular accident 33.26 11.32 1139 843197 106885 62537801
Carpal tunnel syndrome 33.17 11.32 423 843913 20394 62624292
Dental implantation 33.15 11.32 45 844291 697 62643989
Agranulocytosis 33.11 11.32 197 844139 24937 62619749
Hallucination 33.01 11.32 521 843815 54296 62590390
Pleural effusion 32.74 11.32 966 843370 92244 62552442
Toxic epidermal necrolysis 32.62 11.32 200 844136 25134 62619552
Erythema multiforme 32.59 11.32 53 844283 10116 62634570
Hypothermia 32.31 11.32 84 844252 13497 62631189
Jaundice 32.15 11.32 242 844094 29009 62615677
Injection site erythema 31.90 11.32 1382 842954 81792 62562894
Weight increased 31.89 11.32 3948 840388 256844 62387842
Metastases to lung 31.78 11.32 77 844259 12673 62632013
Breast cancer stage I 31.63 11.32 27 844309 6862 62637824
Dysmorphism 31.54 11.32 84 844252 2212 62642474
Multiple sclerosis relapse 31.39 11.32 856 843480 47622 62597064
Renal injury 31.39 11.32 48 844288 9391 62635295
Mania 31.37 11.32 74 844262 12293 62632393
Rash maculo-papular 31.33 11.32 272 844064 31624 62613062
Muscle spasticity 31.07 11.32 434 843902 21360 62623326
Cholecystitis chronic 30.48 11.32 57 844279 10304 62634382
Back pain 30.40 11.32 3984 840352 260161 62384525
Tonsillar ulcer 30.31 11.32 28 844308 275 62644411
Haemodialysis 30.23 11.32 45 844291 8902 62635784
BK virus infection 30.05 11.32 4 844332 3275 62641411
Sleep disorder due to general medical condition, insomnia type 29.94 11.32 908 843428 51309 62593377
Wrist fracture 29.81 11.32 294 844042 13293 62631393
Rash 29.67 11.32 8131 836205 552740 62091946
Neck deformity 29.55 11.32 78 844258 2043 62642643
Tardive dyskinesia 29.48 11.32 42 844294 8460 62636226
Intentional product use issue 29.34 11.32 2026 842310 125866 62518820
Product complaint 29.14 11.32 81 844255 12728 62631958
Proteinuria 29.12 11.32 143 844193 19002 62625684
Cyanosis 29.05 11.32 121 844215 16814 62627872
Cerebral haemorrhage 28.89 11.32 265 844071 30464 62614222
Abortion spontaneous 28.78 11.32 827 843509 46368 62598318
Cytomegalovirus viraemia 28.66 11.32 20 844316 5629 62639057
Malignant melanoma 28.57 11.32 253 844083 11103 62633583
Scoliosis 28.36 11.32 191 844145 7697 62636989
Muscle injury 28.32 11.32 1100 843236 64245 62580441
Oropharyngeal pain 28.24 11.32 1532 842804 92955 62551731
Blood pressure fluctuation 28.08 11.32 811 843525 45506 62599180
Cholestasis 28.03 11.32 253 844083 29181 62615505
Genital haemorrhage 27.69 11.32 34 844302 7298 62637388
Respiratory acidosis 27.69 11.32 29 844307 6686 62638000
Multiple fractures 27.66 11.32 203 844133 8415 62636271
Polyarthritis 27.60 11.32 230 844106 9916 62634770
Toxic encephalopathy 27.59 11.32 28 844308 6551 62638135
Eosinophilia 27.59 11.32 183 844153 22573 62622113
Angina pectoris 27.58 11.32 261 844075 29817 62614869
Cardiomyopathy 27.53 11.32 130 844206 17454 62627232
Lethargy 27.47 11.32 552 843784 55455 62589231
Hypersensitivity 27.38 11.32 4362 839974 288323 62356363
Graft versus host disease in gastrointestinal tract 27.33 11.32 5 844331 3236 62641450
Nasal polyps 27.33 11.32 24 844312 6015 62638671
Injection site swelling 27.21 11.32 827 843509 46745 62597941
Haemorrhage 27.14 11.32 611 843725 60411 62584275
Left ventricular dysfunction 27.13 11.32 76 844260 11912 62632774
Aspergillus infection 27.06 11.32 41 844295 8052 62636634
Bone density abnormal 27.05 11.32 103 844233 3295 62641391
Irritable bowel syndrome 26.81 11.32 1347 842989 81065 62563621
Blood calcium decreased 26.68 11.32 224 844112 26227 62618459
Transplant dysfunction 26.42 11.32 16 844320 4856 62639830
Personality disorder 26.41 11.32 23 844313 5788 62638898
Pulseless electrical activity 26.23 11.32 37 844299 7484 62637202
Bone disorder 26.22 11.32 414 843922 20912 62623774
Colitis ulcerative 26.11 11.32 490 843846 25601 62619085
Abortion incomplete 26.04 11.32 5 844331 3126 62641560
Pregnancy 26.04 11.32 658 843678 36178 62608508
Dental caries 26.02 11.32 238 844098 10541 62634145
Joint laxity 25.98 11.32 82 844254 2382 62642304
Ear pain 25.77 11.32 646 843690 35472 62609214
Dehydration 25.75 11.32 1970 842366 171384 62473302
Anxiety 25.66 11.32 2517 841819 215024 62429662
Exostosis 25.58 11.32 356 843980 17506 62627180
Medical device removal 25.45 11.32 54 844282 1223 62643463
Electrocardiogram QRS complex prolonged 25.22 11.32 25 844311 5913 62638773
Coronary artery disease 25.18 11.32 292 844044 32085 62612601
Hypercalciuria 25.18 11.32 26 844310 296 62644390
Folliculitis 25.13 11.32 1160 843176 69157 62575529
Haemodynamic instability 24.94 11.32 53 844283 9137 62635549
Schizophrenia 24.89 11.32 60 844276 9892 62634794
Multiple sclerosis 24.83 11.32 459 843877 23913 62620773
Drug use disorder 24.82 11.32 18 844318 4966 62639720
Pregnancy with contraceptive device 24.64 11.32 16 844320 4678 62640008
Febrile bone marrow aplasia 24.60 11.32 37 844299 7288 62637398
Removal of internal fixation 24.43 11.32 15 844321 73 62644613
Blood creatinine increased 24.38 11.32 938 843398 86906 62557780
Gestational diabetes 24.28 11.32 193 844143 8203 62636483
Recalled product 24.21 11.32 56 844280 1347 62643339
Confusional state 23.99 11.32 2764 841572 233616 62411070
Epstein-Barr virus infection 23.94 11.32 44 844292 8006 62636680
Fear 23.84 11.32 118 844218 15648 62629038
Blood pressure diastolic abnormal 23.82 11.32 297 844039 14245 62630441
Anhedonia 23.79 11.32 71 844265 10903 62633783
General physical health deterioration 23.71 11.32 3042 841294 198360 62446326
Fibromyalgia 23.65 11.32 1302 843034 79118 62565568
Periprosthetic fracture 23.61 11.32 30 844306 434 62644252
Neutropenic colitis 23.61 11.32 6 844330 3089 62641597
Dyskinesia 23.60 11.32 292 844044 31710 62612976
Tumour lysis syndrome 23.44 11.32 53 844283 8937 62635749
Neurologic neglect syndrome 23.38 11.32 4 844332 2717 62641969
Hypoaesthesia 23.34 11.32 2570 841766 165823 62478863
Anti-neutrophil cytoplasmic antibody positive vasculitis 23.34 11.32 5 844331 2894 62641792
Gastroenteritis viral 23.34 11.32 444 843892 23256 62621430
Dermatitis exfoliative 23.16 11.32 23 844313 5436 62639250
Tendonitis 23.07 11.32 378 843958 19237 62625449
Blood pressure systolic abnormal 23.05 11.32 276 844060 13110 62631576
Laryngitis 23.03 11.32 335 844001 16632 62628054
Purpura 23.03 11.32 76 844260 11309 62633377
Hallucination, auditory 23.02 11.32 90 844246 12734 62631952
Ketoacidosis 22.88 11.32 15 844321 4363 62640323
Bradyphrenia 22.73 11.32 36 844300 6944 62637742
Tenderness 22.58 11.32 424 843912 22154 62622532
Disease recurrence 22.51 11.32 251 844085 27779 62616907
Skin cancer 22.50 11.32 243 844093 11252 62633434
Gastrointestinal toxicity 22.41 11.32 43 844293 7698 62636988
Diabetic ketoacidosis 22.37 11.32 170 844166 20335 62624351
Acute coronary syndrome 22.32 11.32 65 844271 10061 62634625
Lumbar vertebral fracture 22.30 11.32 143 844193 5667 62639019
Paranoia 22.25 11.32 80 844256 11599 62633087
Hepatitis B reactivation 22.22 11.32 7 844329 3130 62641556
Speech disorder 22.22 11.32 393 843943 40236 62604450
Condition aggravated 22.19 11.32 5842 838494 396375 62248311
Metastases to lymph nodes 22.18 11.32 47 844289 8111 62636575
Carotid artery thrombosis 22.13 11.32 5 844331 2789 62641897
Paradoxical drug reaction 22.01 11.32 14 844322 4138 62640548
Hemiplegia 21.92 11.32 58 844278 9265 62635421
Blister 21.86 11.32 2008 842328 127806 62516880
Diabetes mellitus inadequate control 21.86 11.32 115 844221 15011 62629675
Chronic graft versus host disease 21.84 11.32 7 844329 3095 62641591
Myopathy 21.76 11.32 76 844260 11115 62633571
Drug abuser 21.66 11.32 6 844330 2917 62641769
Joint destruction 21.66 11.32 150 844186 6102 62638584
Nephropathy toxic 21.52 11.32 60 844276 9419 62635267
Device dislocation 21.51 11.32 228 844108 25477 62619209
Hyperthermia 21.50 11.32 57 844279 9099 62635587
Sexual dysfunction 21.37 11.32 16 844320 4343 62640343
Hypomagnesaemia 21.27 11.32 262 844074 28475 62616211
Atrioventricular block complete 21.23 11.32 49 844287 8202 62636484
Hyperbilirubinaemia 21.22 11.32 78 844258 11236 62633450
Full blood count decreased 21.18 11.32 474 843862 25550 62619136
Localised infection 21.16 11.32 539 843797 29671 62615015
Product monitoring error 21.08 11.32 117 844219 4399 62640287
Drug-induced liver injury 21.07 11.32 392 843944 39830 62604856
Blood lactate dehydrogenase increased 21.02 11.32 201 844135 22915 62621771
Skin toxicity 21.01 11.32 19 844317 4695 62639991
Drug screen positive 21.00 11.32 11 844325 3618 62641068
Hyperprolactinaemia 20.88 11.32 13 844323 3887 62640799
Affect lability 20.83 11.32 77 844259 11074 62633612
Acute myocardial infarction 20.82 11.32 301 844035 31823 62612863
Talipes 20.81 11.32 56 844280 1484 62643202
Cystic fibrosis 20.79 11.32 93 844243 3203 62641483
Ileus paralytic 20.70 11.32 18 844318 4533 62640153
Endodontic procedure 20.61 11.32 91 844245 3116 62641570
Muscle rigidity 20.46 11.32 81 844255 11419 62633267
Deep vein thrombosis 20.45 11.32 908 843428 82892 62561794
Hypercholesterolaemia 20.44 11.32 398 843938 20936 62623750
Heart rate increased 20.44 11.32 1034 843302 93204 62551482
Weight decreased 20.35 11.32 4074 840262 272724 62371962
Musculoskeletal pain 20.32 11.32 1457 842879 90820 62553866
Chest discomfort 20.27 11.32 1226 843110 108743 62535943
Peripheral sensory neuropathy 20.19 11.32 43 844293 7408 62637278
Fluid retention 19.87 11.32 623 843713 59063 62585623
Subarachnoid haemorrhage 19.86 11.32 110 844226 14173 62630513
Developmental hip dysplasia 19.67 11.32 51 844285 1321 62643365
Muscle strain 19.62 11.32 182 844154 8092 62636594
Myocarditis 19.48 11.32 71 844265 10254 62634432
Withdrawal syndrome 19.43 11.32 171 844165 19826 62624860
Bronchitis 19.33 11.32 1921 842415 123014 62521672
Lumbar spinal stenosis 19.32 11.32 120 844216 4702 62639984
Intraductal proliferative breast lesion 19.26 11.32 84 844252 2861 62641825
Jaundice cholestatic 19.25 11.32 43 844293 7281 62637405
Hallucination, visual 19.21 11.32 164 844172 19134 62625552
Prescribed underdose 19.15 11.32 524 843812 29165 62615521
Adenovirus infection 18.98 11.32 12 844324 3559 62641127
Rotator cuff repair 18.94 11.32 67 844269 2067 62642619
Metabolic disorder 18.93 11.32 36 844300 6467 62638219
Skin papilloma 18.89 11.32 122 844214 4847 62639839
Disturbance in attention 18.84 11.32 376 843960 37813 62606873
Gait spastic 18.81 11.32 21 844315 263 62644423
Live birth 18.76 11.32 460 843876 25170 62619516
Reversible cerebral vasoconstriction syndrome 18.71 11.32 6 844330 2652 62642034
Circulatory collapse 18.60 11.32 194 844142 21744 62622942
Transaminases increased 18.59 11.32 299 844037 31068 62613618
Red blood cell count decreased 18.51 11.32 688 843648 39957 62604729
Pancreatitis acute 18.51 11.32 252 844084 26914 62617772
Myocardial ischaemia 18.45 11.32 98 844238 12761 62631925
Intervertebral disc protrusion 18.41 11.32 429 843907 23280 62621406
Gastrooesophageal reflux disease 18.38 11.32 1494 842842 94145 62550541
Urticaria 18.36 11.32 1927 842409 163875 62480811
Dry eye 18.34 11.32 689 843647 40072 62604614
Pulmonary congestion 18.25 11.32 146 844190 17272 62627414
Leukocytosis 18.25 11.32 239 844097 25696 62618990
Rash erythematous 18.24 11.32 428 843908 42082 62602604
Acidosis 18.20 11.32 82 844254 11151 62633535
Uterine perforation 18.20 11.32 41 844295 6922 62637764
Eosinophil count increased 18.18 11.32 79 844257 10849 62633837
Osteoporotic fracture 18.13 11.32 98 844238 3648 62641038
Influenza 18.04 11.32 1680 842656 107042 62537644
Breast cancer female 18.01 11.32 106 844230 13453 62631233
Blood pressure diastolic decreased 17.99 11.32 412 843924 22294 62622392
Treatment noncompliance 17.97 11.32 369 843967 36956 62607730
Pulmonary hypertension 17.87 11.32 367 843969 36756 62607930
Pulmonary toxicity 17.85 11.32 65 844271 9390 62635296
Loss of employment 17.81 11.32 4 844332 2240 62642446
Hypoglycaemic coma 17.80 11.32 6 844330 2569 62642117
Forced expiratory volume decreased 17.77 11.32 24 844312 4944 62639742
Catatonia 17.72 11.32 20 844316 4457 62640229
Gait disturbance 17.69 11.32 2735 841601 180443 62464243
C-reactive protein abnormal 17.69 11.32 766 843570 45330 62599356
Vitamin D increased 17.67 11.32 33 844303 679 62644007
Meniscus injury 17.64 11.32 158 844178 6956 62637730
Bone metabolism disorder 17.57 11.32 24 844312 374 62644312
Hepatitis cholestatic 17.57 11.32 41 844295 6837 62637849
Second primary malignancy 17.57 11.32 51 844285 7902 62636784
Ileus 17.56 11.32 119 844217 14606 62630080
Drug intolerance 17.53 11.32 4489 839847 304172 62340514
Off label use 17.52 11.32 9533 834803 664929 61979757
Increased tendency to bruise 17.49 11.32 216 844120 10336 62634350
Bradypnoea 17.45 11.32 13 844323 3537 62641149
Muscle spasms 17.42 11.32 2351 841985 153799 62490887
Chronic kidney disease 17.34 11.32 465 843871 44933 62599753
Haemorrhage intracranial 17.24 11.32 106 844230 13313 62631373
Tibia fracture 17.24 11.32 122 844214 4998 62639688
Ear infection 17.21 11.32 646 843690 37567 62607119
Hepatic cytolysis 17.15 11.32 127 844209 15280 62629406
Injection site bruising 17.11 11.32 701 843635 41209 62603477
Oral infection 17.09 11.32 119 844217 4849 62639837
Caesarean section 17.09 11.32 320 844016 16712 62627974
Pulmonary arterial hypertension 17.03 11.32 205 844131 22372 62622314
Dermatitis acneiform 17.01 11.32 25 844311 4971 62639715
Toothache 17.00 11.32 354 843982 18845 62625841
Spinal stenosis 16.96 11.32 286 844050 14639 62630047
Rotator cuff syndrome 16.94 11.32 263 844073 13239 62631447
Arrhythmia 16.92 11.32 382 843954 37758 62606928
Maternal exposure before pregnancy 16.92 11.32 165 844171 7438 62637248
Inadequate analgesia 16.91 11.32 9 844327 2934 62641752
Cytopenia 16.88 11.32 88 844248 11513 62633173
Melaena 16.83 11.32 293 844043 30072 62614614
Dysphoria 16.76 11.32 25 844311 4941 62639745
Small for dates baby 16.73 11.32 96 844240 3655 62641031
Gingival disorder 16.69 11.32 92 844244 3450 62641236
Right ventricular failure 16.69 11.32 147 844189 17041 62627645
Acute chest syndrome 16.69 11.32 35 844301 786 62643900
Total lung capacity increased 16.64 11.32 5 844331 2305 62642381
Haematochezia 16.56 11.32 871 843465 52673 62592013
Graft versus host disease in skin 16.52 11.32 9 844327 2896 62641790
Latent tuberculosis 16.48 11.32 74 844262 2553 62642133
Parkinsonism 16.44 11.32 77 844259 10362 62634324
Joint dislocation 16.44 11.32 346 843990 18454 62626232
Ventricular septal defect 16.34 11.32 107 844229 4271 62640415
Cyst 16.32 11.32 271 844065 13828 62630858
Limb reduction defect 16.31 11.32 24 844312 402 62644284
Tonsillectomy 16.29 11.32 36 844300 839 62643847
Smear cervix abnormal 16.29 11.32 80 844256 2866 62641820
Acute lymphocytic leukaemia recurrent 16.19 11.32 5 844331 2264 62642422
Eye infection 16.17 11.32 239 844097 11906 62632780
Hepatic necrosis 16.11 11.32 32 844304 5655 62639031
Chest pain 16.08 11.32 2574 841762 213385 62431301
Jaw disorder 16.04 11.32 124 844212 5225 62639461
Pericardial effusion 16.04 11.32 292 844044 29766 62614920
Fibula fracture 16.03 11.32 91 844245 3451 62641235
Grip strength decreased 16.01 11.32 399 843937 21888 62622798
Blood lactic acid increased 15.98 11.32 45 844291 7041 62637645
Invasive ductal breast carcinoma 15.97 11.32 152 844184 6806 62637880
Nephritic syndrome 15.97 11.32 21 844315 315 62644371
Bone graft 15.93 11.32 38 844298 933 62643753
Rebound effect 15.92 11.32 109 844227 4417 62640269
Colorectal cancer 15.88 11.32 15 844321 3630 62641056
Flushing 15.87 11.32 826 843510 74261 62570425
Colitis microscopic 15.85 11.32 67 844269 9272 62635414
Pneumothorax 15.82 11.32 139 844197 16122 62628564
Epstein-Barr virus associated lymphoproliferative disorder 15.81 11.32 3 844333 1891 62642795
Folate deficiency 15.74 11.32 70 844266 2405 62642281
Complication associated with device 15.71 11.32 147 844189 16831 62627855
Anticholinergic syndrome 15.70 11.32 6 844330 2376 62642310
Venoocclusive disease 15.68 11.32 4 844332 2054 62642632
Knee operation 15.66 11.32 135 844201 5878 62638808
Atrioventricular block 15.50 11.32 51 844285 7596 62637090
Type I hypersensitivity 15.48 11.32 10 844326 2932 62641754
Cataract 15.48 11.32 917 843419 56136 62588550
Acute pulmonary oedema 15.46 11.32 56 844280 8102 62636584
Spondylolisthesis 15.45 11.32 90 844246 3446 62641240
Product substitution issue 15.45 11.32 137 844199 15859 62628827
Generalised tonic-clonic seizure 15.45 11.32 282 844054 28734 62615952
Endophthalmitis 15.40 11.32 15 844321 3577 62641109
Milk-alkali syndrome 15.34 11.32 34 844302 794 62643892
Hyperammonaemia 15.20 11.32 29 844307 5203 62639483
Parathyroid tumour benign 15.19 11.32 32 844304 721 62643965
Musculoskeletal discomfort 15.17 11.32 329 844007 17638 62627048
Hemiparesis 15.14 11.32 218 844118 23064 62621622
International normalised ratio fluctuation 15.11 11.32 7 844329 2471 62642215
Palmoplantar keratoderma 15.10 11.32 4 844332 2003 62642683
Blood parathyroid hormone increased 15.06 11.32 80 844256 2958 62641728
Humerus fracture 14.99 11.32 183 844153 8733 62635953
Nightmare 14.97 11.32 173 844163 19021 62625665
Surgery 14.97 11.32 602 843734 35310 62609376
Abscess oral 14.95 11.32 51 844285 1544 62643142
Enterocolitis 14.85 11.32 54 844282 7804 62636882
Hyperlipidaemia 14.85 11.32 353 843983 19218 62625468
Ligament rupture 14.79 11.32 87 844249 3343 62641343
Accidental death 14.75 11.32 4 844332 1972 62642714
Pancreatic neuroendocrine tumour 14.69 11.32 23 844313 408 62644278
Visual acuity reduced 14.68 11.32 203 844133 21623 62623063
Thyroid mass 14.65 11.32 102 844234 4156 62640530
Atrial tachycardia 14.65 11.32 21 844315 4219 62640467
Angina unstable 14.60 11.32 47 844289 7048 62637638
Wrong product administered 14.60 11.32 38 844298 6103 62638583
Disability 14.56 11.32 333 844003 18014 62626672
Calcium deficiency 14.55 11.32 40 844296 1074 62643612
Pseudomembranous colitis 14.53 11.32 12 844324 3100 62641586
Tubulointerstitial nephritis 14.53 11.32 182 844154 19721 62624965
Injection site rash 14.50 11.32 340 843996 18469 62626217
Pulmonary haemorrhage 14.48 11.32 48 844288 7133 62637553
Irritability 14.47 11.32 316 844020 31378 62613308
Toxic anterior segment syndrome 14.37 11.32 3 844333 1768 62642918
Pulmonary alveolar haemorrhage 14.34 11.32 25 844311 4643 62640043
Cystitis 14.20 11.32 880 843456 54111 62590575
Anger 14.19 11.32 102 844234 12354 62632332
Generalised oedema 14.19 11.32 138 844198 15680 62629006
Joint stiffness 14.17 11.32 687 843649 41182 62603504
Hungry bone syndrome 14.16 11.32 12 844324 104 62644582
Acute graft versus host disease in intestine 14.12 11.32 3 844333 1746 62642940
Breast cancer stage II 14.02 11.32 64 844272 8672 62636014
Squamous cell carcinoma 14.01 11.32 176 844160 8456 62636230
Cardiac failure acute 13.99 11.32 72 844264 9451 62635235
Type 2 diabetes mellitus 13.98 11.32 1008 843328 62860 62581826
Catheter site erythema 13.97 11.32 22 844314 4254 62640432
Hyperreflexia 13.89 11.32 37 844299 5897 62638789
Cold type haemolytic anaemia 13.88 11.32 16 844320 208 62644478
Lupus-like syndrome 13.87 11.32 283 844053 15012 62629674
Patellofemoral pain syndrome 13.85 11.32 28 844308 612 62644074
Isosthenuria 13.81 11.32 12 844324 108 62644578
Blepharospasm 13.77 11.32 131 844205 5865 62638821
Capillary leak syndrome 13.75 11.32 6 844330 2194 62642492
Drug eruption 13.71 11.32 284 844052 28410 62616276
Stomatitis 13.70 11.32 2074 842262 136651 62508035
Tenosynovitis stenosans 13.66 11.32 84 844252 3280 62641406
Disturbance in social behaviour 13.57 11.32 20 844316 3973 62640713
Spinal compression fracture 13.53 11.32 266 844070 14017 62630669
Lumbar radiculopathy 13.52 11.32 57 844279 1912 62642774
Device malfunction 13.52 11.32 162 844174 17695 62626991
Intracranial pressure increased 13.48 11.32 31 844305 5196 62639490
Edentulous 13.43 11.32 17 844319 245 62644441
Aphasia 13.40 11.32 335 844001 32665 62612021
Blood pH decreased 13.34 11.32 9 844327 2578 62642108
Gastroenteritis astroviral 13.33 11.32 4 844332 0 62644686
Cytomegalovirus infection reactivation 13.33 11.32 20 844316 3943 62640743
Hyperlactacidaemia 13.29 11.32 11 844325 2838 62641848
Limb injury 13.28 11.32 438 843898 25039 62619647
Activated partial thromboplastin time prolonged 13.27 11.32 47 844289 6846 62637840
Heart rate decreased 13.27 11.32 737 843599 44823 62599863
Limb deformity 13.27 11.32 95 844241 3907 62640779
Clostridium difficile colitis 13.24 11.32 193 844143 20376 62624310
Ankle fracture 13.23 11.32 321 844015 17534 62627152
Renal tubular necrosis 13.18 11.32 98 844238 11780 62632906
Erythema 13.16 11.32 2094 842242 173657 62471029
Hepatitis fulminant 13.15 11.32 16 844320 3448 62641238
Swollen tongue 13.15 11.32 357 843979 34443 62610243
Squamous cell carcinoma of skin 13.12 11.32 132 844204 6000 62638686
Amylase increased 13.08 11.32 42 844294 6303 62638383
Liver function test abnormal 13.03 11.32 516 843820 47665 62597021
Nocardiosis 12.98 11.32 5 844331 1971 62642715
Hallucinations, mixed 12.98 11.32 28 844308 4801 62639885
Appendicectomy 12.97 11.32 75 844261 2864 62641822
Alcohol interaction 12.94 11.32 8 844328 2401 62642285
Blood urea increased 12.93 11.32 260 844076 26119 62618567
Blood pressure systolic increased 12.89 11.32 762 843574 46635 62598051
Pupil fixed 12.88 11.32 4 844332 1805 62642881
Upper limb fracture 12.87 11.32 337 843999 18631 62626055
Wheezing 12.85 11.32 1095 843241 94500 62550186
Neck mass 12.81 11.32 87 844249 3516 62641170
Hyperaesthesia teeth 12.78 11.32 53 844283 1765 62642921
Pruritus genital 12.68 11.32 10 844326 2644 62642042
Ligament sprain 12.67 11.32 240 844096 12560 62632126
Neoplasm progression 12.67 11.32 378 843958 36050 62608636
Acute myeloid leukaemia recurrent 12.66 11.32 3 844333 1620 62643066
Coeliac disease 12.62 11.32 109 844227 12688 62631998
Therapeutic product effect incomplete 12.58 11.32 1463 842873 123593 62521093
Cardiac tamponade 12.58 11.32 28 844308 4747 62639939
Wheelchair user 12.56 11.32 134 844202 6185 62638501
Hypophagia 12.51 11.32 318 844018 30941 62613745
Nervous system disorder 12.46 11.32 175 844161 18591 62626095
Enzyme level decreased 12.42 11.32 6 844330 16 62644670
Mouth ulceration 12.41 11.32 547 843789 32437 62612249
Facial paralysis 12.38 11.32 123 844213 13918 62630768
Polyneuropathy 12.37 11.32 129 844207 14460 62630226
Cardiopulmonary failure 12.37 11.32 18 844318 3594 62641092
Periodontal disease 12.34 11.32 49 844287 1599 62643087
Intestinal stenosis 12.34 11.32 73 844263 2811 62641875
Systemic candida 12.30 11.32 15 844321 3230 62641456
Catheter site pain 12.28 11.32 28 844308 4707 62639979
Traumatic arthritis 12.26 11.32 7 844329 29 62644657
Pulse absent 12.21 11.32 34 844302 5340 62639346
Hypervolaemia 12.21 11.32 286 844050 28127 62616559
Seasonal allergy 12.19 11.32 365 843971 20585 62624101
Metastases to meninges 12.19 11.32 10 844326 2592 62642094
Haemorrhage subcutaneous 12.17 11.32 13 844323 2970 62641716
Plantar fasciitis 12.16 11.32 89 844247 3686 62641000
Onychomycosis 12.14 11.32 160 844176 7772 62636914
Breast disorder 12.12 11.32 66 844270 2464 62642222
Decreased appetite 12.11 11.32 3059 841277 247993 62396693
Galactorrhoea 12.10 11.32 23 844313 4132 62640554
Complication of device removal 12.08 11.32 32 844304 5110 62639576
Appendix disorder 12.06 11.32 46 844290 1473 62643213
Osteomalacia 12.05 11.32 29 844307 716 62643970
Cartilage injury 11.89 11.32 55 844281 1922 62642764
Incorrect route of product administration 11.88 11.32 276 844060 27176 62617510
Nodule 11.88 11.32 365 843971 20661 62624025
Amenorrhoea 11.88 11.32 80 844256 9834 62634852
Cyst removal 11.87 11.32 23 844313 487 62644199
Biopsy breast 11.85 11.32 17 844319 278 62644408
Mitral valve prolapse 11.85 11.32 63 844273 2330 62642356
Clear cell renal cell carcinoma 11.81 11.32 45 844291 1440 62643246
Sinus bradycardia 11.80 11.32 130 844206 14421 62630265
Therapy partial responder 11.80 11.32 88 844248 10570 62634116
Groin pain 11.77 11.32 196 844140 10007 62634679
Nephrogenic systemic fibrosis 11.77 11.32 27 844309 4529 62640157
Virologic failure 11.76 11.32 5 844331 1857 62642829
Sleep terror 11.71 11.32 11 844325 2669 62642017
Joint injury 11.70 11.32 493 843843 29079 62615607
Oral disorder 11.70 11.32 174 844162 8680 62636006
Brain death 11.67 11.32 17 844319 3393 62641293
Enthesopathy 11.66 11.32 170 844166 8444 62636242
Malignant mediastinal neoplasm 11.65 11.32 44 844292 1402 62643284
Pneumatosis intestinalis 11.65 11.32 9 844327 2404 62642282
Basosquamous carcinoma 11.64 11.32 5 844331 9 62644677
Immunosuppressant drug level increased 11.62 11.32 19 844317 3619 62641067
Acrochordon 11.60 11.32 36 844300 1036 62643650
Bezoar 11.56 11.32 3 844333 1523 62643163
Oral herpes 11.55 11.32 440 843896 25634 62619052
Prothrombin time prolonged 11.55 11.32 77 844259 9487 62635199
Steroid therapy 11.53 11.32 12 844324 138 62644548
Breast cancer stage IV 11.52 11.32 6 844330 1980 62642706
Congenital arterial malformation 11.51 11.32 18 844318 319 62644367
Atrial septal defect 11.49 11.32 142 844194 6796 62637890
Taste disorder 11.48 11.32 250 844086 13412 62631274
Limb discomfort 11.44 11.32 494 843842 29222 62615464
Limb hypoplasia congenital 11.42 11.32 14 844322 195 62644491
Diabetes mellitus 11.41 11.32 616 843720 55194 62589492
Bladder hypertrophy 11.40 11.32 15 844321 225 62644461
Hyperparathyroidism 11.39 11.32 69 844267 2680 62642006
Anaphylactoid reaction 11.38 11.32 20 844316 3703 62640983
Ischaemic stroke 11.38 11.32 169 844167 17788 62626898
Deafness transitory 11.36 11.32 6 844330 1964 62642722
Kyphosis 11.33 11.32 65 844271 2475 62642211

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Toxicity to various agents 621.19 10.85 539 315385 199823 34441184
Drug abuse 541.41 10.85 117 315807 98979 34542028
Completed suicide 524.07 10.85 122 315802 98046 34542961
Rheumatoid arthritis 319.11 10.85 912 315012 37326 34603681
Drug interaction 244.69 10.85 1130 314794 224816 34416191
Intentional overdose 200.36 10.85 72 315852 43602 34597405
Arthralgia 167.16 10.85 2305 313619 167736 34473271
Fatigue 164.41 10.85 4446 311478 366207 34274800
Hepatic function abnormal 151.41 10.85 108 315816 44255 34596752
Psoriatic arthropathy 137.66 10.85 443 315481 19355 34621652
Foetal exposure during pregnancy 132.04 10.85 687 315237 37414 34603593
Overdose 123.41 10.85 416 315508 90643 34550364
Suicide attempt 108.34 10.85 116 315808 39000 34602007
Multiple organ dysfunction syndrome 105.65 10.85 347 315577 76219 34564788
Coma 105.11 10.85 156 315768 45522 34595485
Psoriasis 101.86 10.85 650 315274 38162 34602845
Drug resistance 101.11 10.85 54 315870 25873 34615134
Sickle cell anaemia with crisis 99.53 10.85 151 315773 3902 34637105
Infective pulmonary exacerbation of cystic fibrosis 97.47 10.85 200 315724 6601 34634406
Death 94.49 10.85 2809 313115 395240 34245767
Acute kidney injury 94.34 10.85 2070 313854 302918 34338089
Fall 94.24 10.85 2450 313474 200435 34440572
Drug reaction with eosinophilia and systemic symptoms 91.31 10.85 98 315826 32914 34608093
Rhabdomyolysis 87.23 10.85 319 315605 67844 34573163
Febrile neutropenia 82.14 10.85 815 315109 136034 34504973
Dysmorphism 80.95 10.85 120 315804 3036 34637971
Nasopharyngitis 79.71 10.85 975 314949 68993 34572014
Cardiac arrest 78.13 10.85 528 315396 95631 34545376
Respiratory arrest 77.83 10.85 83 315841 27960 34613047
Product dose omission issue 75.28 10.85 1509 314415 118202 34522805
Drug ineffective 75.20 10.85 3370 312554 453381 34187626
Joint swelling 73.25 10.85 846 315078 59044 34581963
Peripheral swelling 73.17 10.85 1033 314891 75508 34565499
Renal failure 72.03 10.85 793 315131 129764 34511243
Cytomegalovirus infection 71.82 10.85 78 315846 26057 34614950
Multiple sclerosis relapse 70.64 10.85 270 315654 12863 34628144
Toxic epidermal necrolysis 69.61 10.85 56 315868 21590 34619417
Blood pressure fluctuation 69.44 10.85 428 315496 24821 34616186
Product use in unapproved indication 67.91 10.85 706 315218 116793 34524214
Altered state of consciousness 65.52 10.85 66 315858 22827 34618180
Poisoning 63.59 10.85 16 315908 12210 34628797
Basal cell carcinoma 63.01 10.85 347 315577 19311 34621696
Weight decreased 62.85 10.85 2060 313864 174241 34466766
Speech disorder developmental 62.79 10.85 88 315836 2112 34638895
Cardio-respiratory arrest 61.06 10.85 274 315650 54999 34586008
Serotonin syndrome 59.92 10.85 55 315869 19878 34621129
Disseminated intravascular coagulation 58.96 10.85 66 315858 21750 34619257
Musculoskeletal stiffness 58.69 10.85 663 315261 46017 34594990
Depressed level of consciousness 58.49 10.85 195 315729 42646 34598361
Angioedema 57.52 10.85 161 315763 37213 34603794
Pain 57.23 10.85 2327 313597 202348 34438659
Sedation 56.28 10.85 64 315860 20942 34620065
Disease progression 53.59 10.85 672 315252 107405 34533602
Intentional product misuse 53.50 10.85 221 315703 45390 34595617
Hepatic failure 52.96 10.85 149 315775 34382 34606625
Sinusitis 52.48 10.85 589 315335 40813 34600194
Pathogen resistance 52.12 10.85 11 315913 9471 34631536
Vitamin D deficiency 51.62 10.85 154 315770 6454 34634553
Shock 49.60 10.85 89 315835 24090 34616917
Lactic acidosis 46.97 10.85 159 315765 34613 34606394
Interstitial lung disease 46.49 10.85 372 315552 64910 34576097
Drug withdrawal syndrome 46.34 10.85 67 315857 19767 34621240
Cough 46.16 10.85 1725 314199 148415 34492592
Cardiac failure 45.74 10.85 566 315358 90682 34550325
Maternal exposure during pregnancy 43.64 10.85 120 315804 4798 34636209
Tenosynovitis 43.05 10.85 114 315810 4456 34636551
Vitamin D decreased 42.66 10.85 96 315828 3380 34637627
Post transplant lymphoproliferative disorder 41.66 10.85 5 315919 6523 34634484
Enthesopathy 41.37 10.85 113 315811 4500 34636507
Neuroleptic malignant syndrome 40.52 10.85 62 315862 17872 34623135
Acute hepatic failure 39.79 10.85 41 315883 14033 34626974
Substance abuse 39.74 10.85 10 315914 7631 34633376
Pain in extremity 39.70 10.85 1457 314467 125056 34515951
Influenza 39.60 10.85 650 315274 49016 34591991
General physical health deterioration 39.00 10.85 1472 314452 126797 34514210
Colitis ulcerative 38.70 10.85 269 315655 16251 34624756
Arthritis 37.95 10.85 442 315482 30904 34610103
Suicidal ideation 37.86 10.85 212 315712 40176 34600831
Foetal anticonvulsant syndrome 37.69 10.85 50 315874 1137 34639870
Acute respiratory distress syndrome 37.68 10.85 115 315809 25854 34615153
Respiratory failure 37.53 10.85 723 315201 107849 34533158
Juvenile idiopathic arthritis 37.45 10.85 64 315860 1833 34639174
Neurotoxicity 37.21 10.85 66 315858 17944 34623063
Hypotension 37.16 10.85 1631 314293 220018 34420989
Osteoarthritis 37.12 10.85 316 315608 20326 34620681
Intentional self-injury 36.84 10.85 42 315882 13729 34627278
Mucormycosis 36.84 10.85 5 315919 5937 34635070
Myelosuppression 36.81 10.85 74 315850 19191 34621816
Bone giant cell tumour 36.76 10.85 13 315911 19 34640988
Blood creatine phosphokinase increased 36.55 10.85 246 315678 44611 34596396
Intervertebral disc degeneration 36.23 10.85 134 315790 6283 34634724
Rash maculo-papular 35.17 10.85 135 315789 28316 34612691
Acute graft versus host disease 34.82 10.85 8 315916 6495 34634512
Wound 34.80 10.85 242 315682 14622 34626385
Ventricular fibrillation 34.50 10.85 100 315824 22854 34618153
Stevens-Johnson syndrome 34.42 10.85 73 315851 18566 34622441
Cardiogenic shock 34.41 10.85 124 315800 26494 34614513
Poor venous access 34.24 10.85 114 315810 5069 34635938
Eosinophilia 33.34 10.85 123 315801 26099 34614908
Agitation 33.08 10.85 345 315579 57054 34583953
Relapsing-remitting multiple sclerosis 32.99 10.85 44 315880 1006 34640001
COVID-19 32.89 10.85 926 314998 76624 34564383
Myocardial infarction 32.78 10.85 838 315086 120247 34520760
Somnolence 32.54 10.85 760 315164 110356 34530651
Nephrolithiasis 32.51 10.85 418 315506 29915 34611092
Sopor 32.48 10.85 37 315887 12099 34628908
Neonatal respiratory distress syndrome 32.45 10.85 95 315829 3939 34637068
Synovitis 32.34 10.85 228 315696 13838 34627169
Autism spectrum disorder 32.29 10.85 67 315857 2229 34638778
Venoocclusive liver disease 31.93 10.85 16 315908 7950 34633057
Suspected suicide 31.93 10.85 3 315921 4745 34636262
Ventricular tachycardia 31.66 10.85 128 315796 26451 34614556
Cryptorchism 31.61 10.85 62 315862 1979 34639028
Back pain 31.55 10.85 1374 314550 120415 34520592
Malignant neoplasm progression 31.44 10.85 583 315341 87463 34553544
Osteoporosis 31.29 10.85 209 315715 12459 34628548
Electrocardiogram QT prolonged 31.20 10.85 229 315695 40723 34600284
Upper respiratory tract infection 31.09 10.85 445 315479 32614 34608393
Aspergillus infection 31.05 10.85 39 315885 12215 34628792
Hypoglycaemia neonatal 30.98 10.85 59 315865 1842 34639165
Anaphylactic shock 30.65 10.85 61 315863 15880 34625127
Premature baby 30.42 10.85 291 315633 19342 34621665
Atrial septal defect 30.39 10.85 140 315784 7252 34633755
Red blood cell count decreased 30.39 10.85 399 315525 28691 34612316
Cystitis haemorrhagic 30.38 10.85 7 315917 5672 34635335
Drug ineffective for unapproved indication 30.31 10.85 111 315813 23604 34617403
Hypospadias 30.31 10.85 80 315844 3121 34637886
Immune reconstitution inflammatory syndrome 30.30 10.85 21 315903 8738 34632269
Off label use 30.30 10.85 3325 312599 416199 34224808
Learning disorder 30.19 10.85 43 315881 1048 34639959
Trisomy 18 30.09 10.85 36 315888 735 34640272
Alanine aminotransferase abnormal 29.99 10.85 102 315822 4586 34636421
Anal fissure 29.82 10.85 96 315828 4194 34636813
Bronchopulmonary aspergillosis 29.14 10.85 55 315869 14604 34626403
Arthropathy 28.92 10.85 371 315553 26536 34614471
Memory impairment 28.85 10.85 551 315373 42767 34598240
Thrombocytopenia 28.85 10.85 1137 314787 155110 34485897
Delirium 28.47 10.85 257 315667 43734 34597273
Vomiting 28.41 10.85 1892 314032 245729 34395278
Blood iron decreased 28.38 10.85 109 315815 5204 34635803
Psychotic disorder 28.34 10.85 119 315805 24333 34616674
Poisoning deliberate 28.22 10.85 18 315906 7826 34633181
Acute generalised exanthematous pustulosis 28.09 10.85 13 315911 6763 34634244
Balance disorder 28.07 10.85 520 315404 40134 34600873
Musculoskeletal pain 28.00 10.85 425 315499 31538 34609469
Syndactyly 27.90 10.85 37 315887 841 34640166
Haematotoxicity 27.88 10.85 20 315904 8174 34632833
Maternal exposure during breast feeding 27.84 10.85 50 315874 1491 34639516
Septic shock 27.76 10.85 469 315455 71365 34569642
Exposure during pregnancy 27.49 10.85 156 315768 8778 34632229
Multiple sclerosis 27.43 10.85 126 315798 6519 34634488
Joint effusion 27.30 10.85 106 315818 5087 34635920
Hepatitis 27.30 10.85 117 315807 23787 34617220
Right atrial hypertrophy 27.26 10.85 35 315889 770 34640237
Therapy partial responder 27.20 10.85 28 315896 9588 34631419
Hyperkalaemia 27.15 10.85 452 315472 68937 34572070
Gait spastic 27.15 10.85 41 315883 1055 34639952
Palmar-plantar erythrodysaesthesia syndrome 26.85 10.85 71 315853 16724 34624283
Full blood count decreased 26.51 10.85 265 315659 17823 34623184
Attention deficit hyperactivity disorder 26.34 10.85 66 315858 2493 34638514
Needle fatigue 26.28 10.85 36 315888 845 34640162
Posterior reversible encephalopathy syndrome 25.94 10.85 31 315893 9923 34631084
Brain oedema 25.63 10.85 54 315870 13767 34627240
Renal impairment 25.60 10.85 654 315270 93859 34547148
Miosis 25.60 10.85 29 315895 9506 34631501
Drug dependence 25.58 10.85 122 315802 24095 34616912
Bradycardia 25.51 10.85 504 315420 74914 34566093
Right ventricular hypertrophy 25.48 10.85 48 315876 1486 34639521
C-reactive protein abnormal 25.44 10.85 150 315774 8560 34632447
Bronchial secretion retention 25.43 10.85 48 315876 1488 34639519
Hyperthermia 25.43 10.85 35 315889 10542 34630465
Colorectal cancer 25.21 10.85 6 315918 4755 34636252
Neutropenia 25.14 10.85 1159 314765 155619 34485388
Maternal drugs affecting foetus 25.13 10.85 86 315838 3879 34637128
Mean cell volume increased 24.89 10.85 74 315850 3095 34637912
Acute graft versus host disease in skin 24.84 10.85 8 315916 5193 34635814
Akathisia 24.82 10.85 22 315902 8087 34632920
Small for dates baby 24.73 10.85 85 315839 3842 34637165
Joint laxity 24.45 10.85 24 315900 388 34640619
Appendicolith 24.38 10.85 25 315899 8576 34632431
Urinary tract infection 24.36 10.85 960 314964 83121 34557886
Astigmatism 24.33 10.85 39 315885 1058 34639949
Skin cancer 24.31 10.85 168 315756 10129 34630878
Squamous cell carcinoma of skin 24.21 10.85 175 315749 10706 34630301
Asphyxia 24.16 10.85 16 315908 6819 34634188
Hypoglycaemia 24.06 10.85 348 315576 54292 34586715
Polydactyly 24.05 10.85 41 315883 1172 34639835
Cataract 24.03 10.85 351 315573 25835 34615172
Grip strength decreased 23.95 10.85 73 315851 3096 34637911
Muscle spasticity 23.83 10.85 111 315813 5777 34635230
Thrombotic microangiopathy 23.77 10.85 37 315887 10593 34630414
Foetal malformation 23.56 10.85 15 315909 123 34640884
Metabolic acidosis 23.38 10.85 267 315657 43413 34597594
Aggression 23.35 10.85 232 315692 38732 34602275
Cardiotoxicity 23.16 10.85 11 315913 5637 34635370
Dystonia 23.08 10.85 39 315885 10806 34630201
Graft versus host disease in gastrointestinal tract 23.07 10.85 3 315921 3680 34637327
Tumour lysis syndrome 23.04 10.85 78 315846 16981 34624026
Multimorbidity 22.99 10.85 35 315889 907 34640100
Atrioventricular septal defect 22.66 10.85 18 315906 216 34640791
Cellulitis 22.65 10.85 633 315291 52318 34588689
Spinal stenosis 22.57 10.85 101 315823 5168 34635839
Electrocardiogram QRS complex prolonged 22.55 10.85 8 315916 4886 34636121
Low birth weight baby 22.36 10.85 135 315789 7770 34633237
Myoclonus 22.23 10.85 64 315860 14661 34626346
Chronic graft versus host disease 22.21 10.85 6 315918 4367 34636640
Cerebral infarction 22.15 10.85 151 315773 27304 34613703
Withdrawal syndrome 21.99 10.85 50 315874 12405 34628602
Melaena 21.90 10.85 209 315715 35171 34605836
Ear infection 21.88 10.85 163 315761 10068 34630939
Foot deformity 21.76 10.85 90 315834 4447 34636560
Sleep apnoea syndrome 21.76 10.85 280 315644 20041 34620966
Gait disturbance 21.69 10.85 959 314965 84181 34556826
Hepatotoxicity 21.67 10.85 110 315814 21375 34619632
Gastrooesophageal reflux disease 21.49 10.85 471 315453 37453 34603554
Neurodevelopmental disorder 21.47 10.85 23 315901 414 34640593
Rheumatoid nodule 21.45 10.85 67 315857 2880 34638127
Hypertransaminasaemia 21.38 10.85 12 315912 5594 34635413
Wrong technique in product usage process 21.26 10.85 215 315709 35771 34605236
Hypermobility syndrome 21.17 10.85 21 315903 344 34640663
Intellectual disability 21.16 10.85 41 315883 1297 34639710
Hip fracture 21.15 10.85 182 315742 11743 34629264
Aortic valve stenosis 21.12 10.85 63 315861 2640 34638367
Blood pressure systolic abnormal 21.09 10.85 81 315843 3867 34637140
Developmental delay 21.04 10.85 64 315860 2711 34638296
Congenital central nervous system anomaly 20.99 10.85 27 315897 595 34640412
Intraductal papillary mucinous neoplasm 20.91 10.85 25 315899 510 34640497
Blood pressure increased 20.85 10.85 985 314939 87117 34553890
Agranulocytosis 20.75 10.85 128 315796 23693 34617314
Victim of child abuse 20.62 10.85 33 315891 894 34640113
Mucous stools 20.60 10.85 48 315876 1730 34639277
Mydriasis 20.55 10.85 21 315903 7216 34633791
Heart rate decreased 20.53 10.85 402 315522 31343 34609664
Dysgraphia 20.49 10.85 56 315868 2231 34638776
Renal cyst haemorrhage 20.42 10.85 27 315897 612 34640395
Back disorder 20.38 10.85 116 315808 6535 34634472
Blood pressure diastolic abnormal 20.37 10.85 92 315832 4726 34636281
Pulmonary fibrosis 20.34 10.85 255 315669 18141 34622866
Talipes 20.22 10.85 50 315874 1873 34639134
Hypertonic bladder 20.17 10.85 49 315875 1815 34639192
Unresponsive to stimuli 20.13 10.85 156 315768 27413 34613594
Haematochezia 20.10 10.85 557 315367 45977 34595030
Localised infection 19.97 10.85 245 315679 17342 34623665
Angina pectoris 19.96 10.85 184 315740 31179 34609828
Body height decreased 19.84 10.85 78 315846 3765 34637242
Jaundice neonatal 19.78 10.85 40 315884 1306 34639701
Contusion 19.78 10.85 449 315475 35915 34605092
Coronary artery disease 19.78 10.85 312 315612 47993 34593014
Folate deficiency 19.74 10.85 38 315886 1196 34639811
Intentional dose omission 19.69 10.85 73 315851 3427 34637580
Status epilepticus 19.66 10.85 54 315870 12560 34628447
Benign prostatic hyperplasia 19.64 10.85 209 315715 14286 34626721
Soft tissue mass 19.62 10.85 34 315890 985 34640022
Red cell distribution width increased 19.56 10.85 108 315816 6015 34634992
Nephropathy toxic 19.53 10.85 54 315870 12534 34628473
Endophthalmitis 19.42 10.85 4 315920 3504 34637503
Disinhibition 19.33 10.85 3 315921 3223 34637784
Abdominal wall haemorrhage 19.32 10.85 23 315901 467 34640540
Rectal prolapse 19.25 10.85 23 315901 469 34640538
Plasma cell myeloma 19.24 10.85 507 315417 41530 34599477
Hypercalcaemia 19.11 10.85 219 315705 15249 34625758
Nocardiosis 19.01 10.85 6 315918 3945 34637062
Oesophageal adenocarcinoma 19.00 10.85 31 315893 854 34640153
Language disorder 18.99 10.85 54 315870 2202 34638805
Oropharyngeal pain 18.94 10.85 437 315487 35048 34605959
Weight increased 18.90 10.85 1025 314899 92008 34548999
Ventricular septal defect 18.90 10.85 79 315845 3922 34637085
Multiple-drug resistance 18.88 10.85 12 315912 5227 34635780
Melanoderma 18.84 10.85 14 315910 151 34640856
Inguinal hernia 18.83 10.85 126 315798 7515 34633492
Plagiocephaly 18.83 10.85 24 315900 524 34640483
Lymphoid tissue hypoplasia 18.80 10.85 21 315903 397 34640610
Thymus hypoplasia 18.80 10.85 21 315903 397 34640610
Congenital hand malformation 18.80 10.85 25 315899 570 34640437
Exposure via breast milk 18.79 10.85 50 315874 1960 34639047
Systemic infection 18.75 10.85 95 315829 5117 34635890
Exposure to toxic agent 18.75 10.85 5 315919 3670 34637337
Haemodynamic instability 18.69 10.85 36 315888 9487 34631520
Macrocephaly 18.65 10.85 23 315901 485 34640522
Hyperammonaemia 18.63 10.85 18 315906 6349 34634658
Frequent bowel movements 18.57 10.85 187 315737 12600 34628407
Malignant melanoma 18.52 10.85 131 315793 7959 34633048
Blood 25-hydroxycholecalciferol decreased 18.49 10.85 17 315907 252 34640755
Urticaria 18.42 10.85 426 315498 61951 34579056
Gastrointestinal infection 18.34 10.85 102 315822 5696 34635311
Tongue disorder 18.30 10.85 96 315828 5243 34635764
Sexual dysfunction 18.23 10.85 18 315906 6285 34634722
Blood pressure systolic increased 18.14 10.85 300 315624 22652 34618355
Lipodystrophy acquired 18.13 10.85 4 315920 3340 34637667
Spinal fracture 18.10 10.85 123 315801 7375 34633632
Cytomegalovirus chorioretinitis 18.09 10.85 5 315919 3584 34637423
Abdominal discomfort 17.99 10.85 686 315238 59149 34581858
Hand deformity 17.95 10.85 74 315850 3651 34637356
Hyperhidrosis 17.85 10.85 534 315390 75158 34565849
Acute chest syndrome 17.80 10.85 29 315895 798 34640209
Hypochromasia 17.76 10.85 18 315906 303 34640704
Cerebral haemorrhage 17.76 10.85 216 315708 34721 34606286
Pyrexia 17.66 10.85 2691 313233 330322 34310685
Loss of consciousness 17.62 10.85 591 315333 82076 34558931
Drug use disorder 17.44 10.85 8 315916 4183 34636824
Hepatitis fulminant 17.43 10.85 8 315916 4182 34636825
Graft versus host disease 17.42 10.85 44 315880 10525 34630482
Serum ferritin increased 17.41 10.85 105 315819 6041 34634966
Coagulopathy 17.41 10.85 106 315818 19683 34621324
Pneumonia aspiration 17.37 10.85 270 315654 41633 34599374
Mobility decreased 17.33 10.85 375 315549 29753 34611254
Virologic failure 17.26 10.85 5 315919 3475 34637532
Anal fistula 17.09 10.85 95 315829 5304 34635703
Pancreatitis 17.01 10.85 248 315676 38643 34602364
Tendonitis 17.00 10.85 141 315783 8999 34632008
Rhinorrhoea 16.92 10.85 326 315598 25342 34615665
Large for dates baby 16.86 10.85 30 315894 888 34640119
Spinal osteoarthritis 16.77 10.85 123 315801 7560 34633447
Haematocrit decreased 16.66 10.85 395 315529 31821 34609186
Finger deformity 16.61 10.85 40 315884 1473 34639534
Motor developmental delay 16.56 10.85 25 315899 643 34640364
Polyomavirus-associated nephropathy 16.53 10.85 7 315917 3837 34637170
Night sweats 16.48 10.85 234 315690 17118 34623889
Lower respiratory tract infection 16.39 10.85 388 315536 31249 34609758
Spinal disorder 16.36 10.85 79 315845 4173 34636834
Proteinuria 16.32 10.85 100 315824 18542 34622465
Fracture 16.32 10.85 112 315812 6737 34634270
Therapy non-responder 16.31 10.85 252 315672 38894 34602113
Anaphylactic reaction 16.30 10.85 200 315724 32101 34608906
Diarrhoea 16.29 10.85 3866 312058 386046 34254961
Emotional distress 16.28 10.85 75 315849 14951 34626056
Blood creatinine increased 16.26 10.85 697 315227 94279 34546728
Torsade de pointes 16.21 10.85 25 315899 7184 34633823
Central nervous system lesion 16.19 10.85 107 315817 6356 34634651
Heparin-induced thrombocytopenia 16.16 10.85 16 315908 5579 34635428
Mania 16.14 10.85 39 315885 9472 34631535
Maternal exposure before pregnancy 16.03 10.85 27 315897 764 34640243
Obsessive-compulsive disorder 15.97 10.85 16 315908 5548 34635459
Bronchitis 15.86 10.85 494 315430 41469 34599538
Pancreatic failure 15.86 10.85 27 315897 771 34640236
Anuria 15.78 10.85 45 315879 10340 34630667
Ear disorder 15.76 10.85 42 315882 1648 34639359
Post procedural infection 15.75 10.85 86 315838 4770 34636237
Nocturia 15.65 10.85 151 315773 10059 34630948
Immunodeficiency 15.62 10.85 94 315830 5404 34635603
Productive cough 15.60 10.85 450 315474 37363 34603644
Microcephaly 15.54 10.85 27 315897 784 34640223
Hydrops foetalis 15.50 10.85 28 315896 839 34640168
Ankylosing spondylitis 15.41 10.85 95 315829 5509 34635498
Dandy-Walker syndrome 15.37 10.85 14 315910 205 34640802
Diffuse large B-cell lymphoma recurrent 15.36 10.85 5 315919 3223 34637784
Tubulointerstitial nephritis 15.33 10.85 119 315805 20905 34620102
Hepatitis B reactivation 15.32 10.85 8 315916 3883 34637124
Euglycaemic diabetic ketoacidosis 15.31 10.85 5 315919 3217 34637790
Umbilical hernia 15.28 10.85 83 315841 4594 34636413
Hepatitis B 15.20 10.85 19 315905 5964 34635043
Gastric haemorrhage 15.20 10.85 45 315879 10216 34630791
Kidney infection 15.18 10.85 92 315832 5302 34635705
Knee deformity 15.16 10.85 24 315900 644 34640363
Hepatocellular injury 15.15 10.85 128 315796 22083 34618924
Apparent death 15.09 10.85 7 315917 3637 34637370
Headache 15.04 10.85 2051 313873 198584 34442423
Knee arthroplasty 15.03 10.85 117 315807 7327 34633680
Right atrial enlargement 15.01 10.85 15 315909 248 34640759
Vitamin B12 deficiency 14.87 10.85 74 315850 3957 34637050
Atypical fracture 14.86 10.85 11 315913 118 34640889
Bronchial wall thickening 14.84 10.85 36 315888 1332 34639675
Dyspraxia 14.80 10.85 19 315905 418 34640589
Red blood cell sedimentation rate increased 14.79 10.85 137 315787 9025 34631982
Hepatitis cholestatic 14.78 10.85 31 315893 7916 34633091
Hydrocele 14.78 10.85 47 315877 2040 34638967
Tachycardia 14.74 10.85 621 315303 84151 34556856
Otitis media 14.59 10.85 58 315866 2814 34638193
Phospholipidosis 14.59 10.85 8 315916 48 34640959
Gastrointestinal stoma complication 14.57 10.85 35 315889 1287 34639720
Abdominal adhesions 14.52 10.85 38 315886 1475 34639532
Second primary malignancy 14.47 10.85 31 315893 7855 34633152
Inappropriate schedule of product administration 14.42 10.85 695 315229 61601 34579406
Drug abuser 14.33 10.85 9 315915 3945 34637062
Blood test abnormal 14.31 10.85 110 315814 6861 34634146
Loss of personal independence in daily activities 14.28 10.85 397 315527 32782 34608225
Pulmonary alveolar haemorrhage 14.23 10.85 29 315895 7483 34633524
Schizophrenia 14.20 10.85 130 315794 8536 34632471
Hypersomnia 14.16 10.85 173 315751 12234 34628773
Monoparesis 14.10 10.85 50 315874 2296 34638711
Toxic skin eruption 14.08 10.85 54 315870 11331 34629676
Eosinophil percentage increased 14.06 10.85 21 315903 535 34640472
Ultrasound antenatal screen 14.06 10.85 21 315903 535 34640472
Transplant rejection 14.02 10.85 47 315877 10264 34630743
Impaired fasting glucose 13.99 10.85 14 315910 232 34640775
Urosepsis 13.97 10.85 177 315747 12622 34628385
Drug level increased 13.90 10.85 130 315794 21966 34619041
Drug eruption 13.87 10.85 114 315810 19784 34621223
Latent tuberculosis 13.87 10.85 35 315889 1328 34639679
Incorrect route of product administration 13.87 10.85 78 315846 14767 34626240
Tooth fracture 13.85 10.85 68 315856 3617 34637390
Catatonia 13.80 10.85 15 315909 5010 34635997
Viral infection 13.80 10.85 230 315694 17393 34623614
Compartment syndrome 13.79 10.85 5 315919 3013 34637994
BK virus infection 13.78 10.85 19 315905 5719 34635288
Vascular compression 13.77 10.85 17 315907 359 34640648
Haemoglobin decreased 13.76 10.85 1269 314655 119503 34521504
Anhedonia 13.76 10.85 30 315894 7555 34633452
Dyslexia 13.70 10.85 16 315908 318 34640689
Hypoaesthesia 13.70 10.85 683 315241 60761 34580246
Lip swelling 13.69 10.85 87 315837 15993 34625014
SARS-CoV-2 antibody test positive 13.68 10.85 18 315906 406 34640601
Viral acanthoma 13.68 10.85 6 315918 20 34640987
Nodule 13.67 10.85 107 315817 6712 34634295
Hyperparathyroidism secondary 13.66 10.85 38 315886 1530 34639477
Dry throat 13.59 10.85 51 315873 2408 34638599
Blood lactic acid increased 13.59 10.85 25 315899 6703 34634304
Congenital hydronephrosis 13.52 10.85 24 315900 709 34640298
Oesophageal perforation 13.49 10.85 32 315892 1167 34639840
Vena cava injury 13.47 10.85 16 315908 324 34640683
Hypokalaemia 13.40 10.85 412 315512 57802 34583205
Rectal tenesmus 13.34 10.85 26 315898 826 34640181
Monocyte percentage increased 13.30 10.85 28 315896 941 34640066
Prostate cancer stage IV 13.29 10.85 3 315921 2465 34638542
Spinal pain 13.27 10.85 95 315829 5794 34635213
Diaphragmatic disorder 13.25 10.85 33 315891 1242 34639765
Flatulence 13.22 10.85 267 315657 20931 34620076
Vascular stent thrombosis 13.18 10.85 5 315919 2930 34638077
Diabetic ketoacidosis 13.18 10.85 102 315822 17930 34623077
Polyarthritis 13.14 10.85 78 315846 4462 34636545
Asthenia 13.12 10.85 2461 313463 242790 34398217
Impaired healing 13.08 10.85 203 315721 15131 34625876
Hyperparathyroidism 13.05 10.85 32 315892 1192 34639815
Inflammatory marker increased 13.05 10.85 84 315840 4944 34636063
Urine calcium/creatinine ratio increased 13.05 10.85 6 315918 23 34640984
Paradoxical drug reaction 13.03 10.85 7 315917 3344 34637663
Blood parathyroid hormone decreased 13.02 10.85 36 315888 1444 34639563
Psychomotor hyperactivity 12.99 10.85 44 315880 9578 34631429
Fistula discharge 12.94 10.85 26 315898 845 34640162
Drug-induced liver injury 12.91 10.85 183 315741 28649 34612358
Arthropod bite 12.91 10.85 55 315869 2754 34638253
Caesarean section 12.90 10.85 46 315878 2118 34638889
Hypophosphatasia 12.90 10.85 7 315917 41 34640966
Vitamin B complex deficiency 12.87 10.85 17 315907 385 34640622
Neck pain 12.86 10.85 310 315614 25039 34615968
Urge incontinence 12.82 10.85 20 315904 530 34640477
Perineal cyst 12.81 10.85 14 315910 258 34640749
Rib fracture 12.81 10.85 192 315732 14208 34626799
Epidural lipomatosis 12.81 10.85 29 315895 1025 34639982
Enterocolitis 12.78 10.85 34 315890 7992 34633015
Laboratory test abnormal 12.77 10.85 257 315667 20134 34620873
Haemorrhage intracranial 12.71 10.85 88 315836 15858 34625149
Venoocclusive disease 12.69 10.85 5 315919 2862 34638145
Nerve compression 12.68 10.85 61 315863 3218 34637789
Renal injury 12.66 10.85 55 315869 11140 34629867
Diverticular perforation 12.64 10.85 63 315861 3371 34637636
Upper limb fracture 12.61 10.85 80 315844 4686 34636321
Cyst 12.60 10.85 77 315847 4451 34636556
Phlebitis infective 12.59 10.85 10 315914 120 34640887
Acne 12.49 10.85 154 315770 10912 34630095
Weight gain poor 12.48 10.85 29 315895 1043 34639964
Fistula 12.45 10.85 105 315819 6735 34634272
Low turnover osteopathy 12.43 10.85 9 315915 93 34640914
Hyperbilirubinaemia neonatal 12.41 10.85 24 315900 758 34640249
Hyperglycaemia 12.40 10.85 267 315657 39213 34601794
Ascites 12.40 10.85 323 315601 46248 34594759
Epstein-Barr virus infection 12.38 10.85 32 315892 7596 34633411
Pectus excavatum 12.36 10.85 13 315911 229 34640778
Nephrotic syndrome 12.35 10.85 30 315894 7273 34633734
Muscle spasms 12.33 10.85 811 315113 74190 34566817
C-reactive protein decreased 12.32 10.85 43 315881 1959 34639048
Ageusia 12.32 10.85 145 315779 10163 34630844
Strabismus 12.27 10.85 39 315885 1692 34639315
Neoplasm progression 12.24 10.85 143 315781 23157 34617850
Pulmonary function test decreased 12.24 10.85 82 315842 4893 34636114
Bronchiolitis 12.22 10.85 59 315865 3117 34637890
Dysstasia 12.21 10.85 166 315758 12029 34628978
Vascular anastomotic haemorrhage 12.20 10.85 14 315910 273 34640734
Respiratory tract infection viral 12.13 10.85 50 315874 2467 34638540
Cardiac failure chronic 12.08 10.85 34 315890 7845 34633162
Limb injury 12.07 10.85 160 315764 11529 34629478
Incorrect dose administered 12.06 10.85 464 315460 40051 34600956
Adenovirus infection 12.04 10.85 18 315906 5239 34635768
Limb reduction defect 12.04 10.85 14 315910 277 34640730
Pulmonary haemorrhage 12.03 10.85 50 315874 10254 34630753
Toxic encephalopathy 12.00 10.85 18 315906 5231 34635776
Lacrimal disorder 12.00 10.85 15 315909 321 34640686
Hernia 11.98 10.85 136 315788 9447 34631560
Bone marrow failure 11.95 10.85 189 315735 29064 34611943
Hyponatraemia 11.92 10.85 618 315306 82073 34558934
Cervical radiculopathy 11.92 10.85 18 315906 463 34640544
Weight decrease neonatal 11.89 10.85 15 315909 324 34640683
Weight fluctuation 11.89 10.85 84 315840 5101 34635906
Respiratory disorder neonatal 11.81 10.85 37 315887 1593 34639414
Alcohol abuse 11.81 10.85 15 315909 4675 34636332
Blood pressure diastolic decreased 11.80 10.85 130 315794 8964 34632043
Pre-eclampsia 11.78 10.85 7 315917 50 34640957
Hypoacusis 11.77 10.85 210 315714 16091 34624916
Ventricular hyperkinesia 11.74 10.85 12 315912 204 34640803
Drug screen positive 11.71 10.85 11 315913 3932 34637075
Neutrophil count decreased 11.69 10.85 362 315562 50742 34590265
Appendicitis 11.66 10.85 82 315842 14725 34626282
Oxygen saturation 11.65 10.85 12 315912 206 34640801
Selective eating disorder 11.65 10.85 39 315885 1739 34639268
Trismus 11.63 10.85 4 315920 2491 34638516
Congenital foot malformation 11.62 10.85 17 315907 425 34640582
Ileal stenosis 11.57 10.85 33 315891 1348 34639659
Renal aplasia 11.54 10.85 23 315901 743 34640264
Acute graft versus host disease in intestine 11.53 10.85 5 315919 2703 34638304
Device loosening 11.51 10.85 10 315914 137 34640870
Blood pressure abnormal 11.51 10.85 118 315806 7988 34633019
Nasal disorder 11.51 10.85 41 315883 1887 34639120
Lip ulceration 11.48 10.85 23 315901 746 34640261
Cystic fibrosis 11.43 10.85 37 315887 1621 34639386
Vein disorder 11.43 10.85 32 315892 1293 34639714
Encephalopathy 11.35 10.85 238 315686 35081 34605926
Bladder transitional cell carcinoma recurrent 11.34 10.85 10 315914 140 34640867
Cytopenia 11.27 10.85 68 315856 12655 34628352
Cytomegalovirus infection reactivation 11.27 10.85 18 315906 5100 34635907
CSF shunt operation 11.25 10.85 4 315920 6 34641001
Disseminated aspergillosis 11.25 10.85 23 315901 757 34640250
Pruritus genital 11.24 10.85 3 315921 2201 34638806
Accessory spleen 11.17 10.85 10 315914 143 34640864
Pancreatic carcinoma 11.15 10.85 42 315882 8859 34632148
Hypnopompic hallucination 11.15 10.85 3 315921 0 34641007
Gallbladder mucocoele 11.15 10.85 3 315921 0 34641007
Excessive skin 11.15 10.85 3 315921 0 34641007
Wrong patient received product 11.15 10.85 5 315919 2649 34638358
Ceruloplasmin decreased 11.15 10.85 3 315921 0 34641007
Menopausal symptoms 11.15 10.85 3 315921 0 34641007
Hypotonia neonatal 11.13 10.85 32 315892 1313 34639694
Radiation inflammation 11.11 10.85 25 315899 880 34640127
Muscle rigidity 11.10 10.85 53 315871 10465 34630542
Exposure via ingestion 11.06 10.85 3 315921 2178 34638829
Arthrodesis 11.04 10.85 17 315907 445 34640562
Pulmonary oedema 11.03 10.85 336 315588 47193 34593814
Intestinal stenosis 10.99 10.85 44 315880 2142 34638865
Cleft lip and palate 10.98 10.85 25 315899 887 34640120
Joint injury 10.94 10.85 129 315795 9044 34631963
Joint instability 10.93 10.85 17 315907 449 34640558
Aphthous ulcer 10.92 10.85 80 315844 4915 34636092
Medical device implantation 10.91 10.85 20 315904 606 34640401
Joint stiffness 10.88 10.85 148 315776 10725 34630282
Aplastic anaemia 10.88 10.85 135 315789 9581 34631426

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 1950.81 10.72 236 896581 245531 78602040
Toxicity to various agents 1942.20 10.72 1169 895648 420371 78427200
Drug abuse 1168.68 10.72 209 896608 162482 78685089
Drug interaction 688.96 10.72 2379 894438 412804 78434767
Intentional overdose 642.42 10.72 196 896621 105764 78741807
Rheumatoid arthritis 593.92 10.72 4198 892619 204272 78643299
Arthralgia 516.83 10.72 9164 887653 562639 78284932
Overdose 459.01 10.72 857 895960 183349 78664222
Death 431.24 10.72 4182 892635 562332 78285239
Arthropathy 423.96 10.72 3424 893393 173687 78673884
Cardiac arrest 408.49 10.72 824 895993 171272 78676299
Joint swelling 403.81 10.72 4991 891826 283655 78563916
Pain 394.53 10.72 10529 886288 693273 78154298
Fatigue 381.93 10.72 13387 883430 916340 77931231
Systemic lupus erythematosus 359.04 10.72 2464 894353 118685 78728886
Pemphigus 347.01 10.72 2110 894707 97472 78750099
Depressed level of consciousness 340.64 10.72 350 896467 96302 78751269
Suicide attempt 338.25 10.72 262 896555 82670 78764901
Hepatic function abnormal 336.84 10.72 202 896615 72905 78774666
Alopecia 332.79 10.72 4022 892795 227333 78620238
Febrile neutropenia 330.68 10.72 1404 895413 229595 78617976
Hand deformity 328.01 10.72 2147 894670 101772 78745799
Glossodynia 320.72 10.72 2126 894691 101211 78746360
Wound 297.10 10.72 2281 894536 113898 78733673
Cardio-respiratory arrest 292.75 10.72 480 896337 108030 78739541
Abdominal discomfort 287.11 10.72 4182 892635 246545 78601026
Respiratory arrest 285.44 10.72 145 896672 57405 78790166
Synovitis 282.62 10.72 2763 894054 147971 78699600
Nasopharyngitis 275.63 10.72 4196 892621 249685 78597886
Coma 274.54 10.72 442 896375 100207 78747364
Acute kidney injury 274.25 10.72 4150 892667 515254 78332317
Multiple organ dysfunction syndrome 255.40 10.72 612 896205 119634 78727937
Maternal exposure during pregnancy 246.83 10.72 2484 894333 134054 78713517
Anti-cyclic citrullinated peptide antibody positive 244.48 10.72 1688 895129 81455 78766116
Drug reaction with eosinophilia and systemic symptoms 235.15 10.72 225 896592 64019 78783552
Drug resistance 231.85 10.72 92 896725 42121 78805450
Sinusitis 224.14 10.72 3262 893555 192239 78655332
Sedation 223.22 10.72 155 896662 51740 78795831
Musculoskeletal stiffness 218.70 10.72 2965 893852 172043 78675528
Rhabdomyolysis 215.76 10.72 529 896288 102602 78744969
Peripheral swelling 214.60 10.72 4240 892577 265377 78582194
Renal failure 206.74 10.72 1366 895451 199602 78647969
Psoriatic arthropathy 205.86 10.72 1543 895274 76456 78771115
Pericarditis 204.36 10.72 1929 894888 102307 78745264
Hypotension 201.28 10.72 3612 893205 436705 78410866
Lactic acidosis 198.51 10.72 302 896515 70057 78777514
Infusion related reaction 195.55 10.72 3657 893160 226580 78620991
Osteoarthritis 191.70 10.72 1656 895161 85653 78761918
Serotonin syndrome 189.05 10.72 138 896679 44889 78802682
Malignant neoplasm progression 186.90 10.72 839 895978 135151 78712420
Femur fracture 186.90 10.72 896 895921 37756 78809815
Swelling 178.81 10.72 3427 893390 213284 78634287
Discomfort 175.73 10.72 2173 894644 123444 78724127
Cytomegalovirus infection 174.79 10.72 134 896683 42510 78805061
Pain in extremity 172.00 10.72 5340 891477 359198 78488373
Psoriasis 168.72 10.72 1644 895173 87943 78759628
Poisoning 165.81 10.72 40 896777 25232 78822339
Hepatic failure 164.86 10.72 271 896546 60941 78786630
Cardiac failure 164.55 10.72 1042 895775 153800 78693771
Impaired healing 163.83 10.72 1606 895211 86049 78761522
Altered state of consciousness 158.60 10.72 155 896662 43667 78803904
Disseminated intravascular coagulation 156.89 10.72 105 896712 35737 78811834
Sickle cell anaemia with crisis 155.79 10.72 302 896515 7620 78839951
Fall 155.70 10.72 6837 889980 480792 78366779
Shock 148.59 10.72 162 896655 43386 78804185
Respiratory failure 146.80 10.72 1313 895504 179598 78667973
Therapeutic product effect decreased 144.72 10.72 2619 894198 161244 78686327
Poisoning deliberate 144.57 10.72 20 896797 18808 78828763
Myocardial infarction 142.22 10.72 1353 895464 182776 78664795
Agitation 141.36 10.72 608 896209 99107 78748464
Helicobacter infection 140.63 10.72 1298 895519 68406 78779165
Electrocardiogram QT prolonged 140.17 10.72 532 896285 89854 78757717
Neutropenia 139.05 10.72 2336 894481 285374 78562197
Duodenal ulcer perforation 135.62 10.72 1237 895580 64974 78782597
Intentional self-injury 135.27 10.72 100 896717 32319 78815252
Thrombocytopenia 134.03 10.72 2136 894681 263123 78584448
Weight increased 133.30 10.72 4073 892744 273313 78574258
Metabolic acidosis 130.42 10.72 482 896335 82047 78765524
Rheumatoid factor positive 129.26 10.72 1131 895686 58708 78788863
Disease progression 125.81 10.72 1395 895422 182967 78664604
Bradycardia 125.37 10.72 950 895867 134607 78712964
Infective pulmonary exacerbation of cystic fibrosis 124.26 10.72 372 896445 12479 78835092
Ventricular tachycardia 124.16 10.72 174 896643 41761 78805810
Product dose omission issue 124.12 10.72 3654 893163 243883 78603688
Myelosuppression 123.55 10.72 163 896654 40133 78807438
Arthritis 120.39 10.72 1888 894929 112992 78734579
Intentional product misuse 119.69 10.72 606 896211 94559 78753012
Product use in unapproved indication 117.30 10.72 2044 894773 248315 78599256
Multiple sclerosis relapse 116.87 10.72 910 895907 45623 78801948
Drug hypersensitivity 115.85 10.72 2520 894297 296396 78551175
COVID-19 112.96 10.72 2442 894375 155232 78692339
Mydriasis 108.04 10.72 32 896785 17611 78829960
Drug ineffective for unapproved indication 107.79 10.72 262 896555 50976 78796595
Somnolence 107.54 10.72 1965 894852 237016 78610555
Ventricular fibrillation 106.47 10.72 121 896696 31805 78815766
Blood creatine phosphokinase increased 106.40 10.72 383 896434 65707 78781864
Neuroleptic malignant syndrome 106.22 10.72 92 896725 27467 78820104
Lower respiratory tract infection 105.65 10.72 2041 894776 127179 78720392
Angioedema 105.10 10.72 468 896349 75567 78772004
Hyperkalaemia 104.23 10.72 805 896012 113593 78733978
Osteoporosis 103.82 10.72 997 895820 53115 78794456
Acute respiratory distress syndrome 101.92 10.72 214 896603 43853 78803718
Cardiogenic shock 101.67 10.72 198 896619 41716 78805855
Post transplant lymphoproliferative disorder 101.54 10.72 7 896810 11457 78836114
Blood pressure fluctuation 100.18 10.72 1176 895641 65969 78781602
Hepatic enzyme increased 99.67 10.72 2725 894092 179885 78667686
Interstitial lung disease 99.49 10.72 799 896018 111801 78735770
Acute hepatic failure 99.48 10.72 115 896702 29998 78817573
Contraindicated product administered 98.27 10.72 2393 894424 155145 78692426
Contusion 97.09 10.72 2274 894543 146502 78701069
Red blood cell sedimentation rate abnormal 96.36 10.72 479 896338 20484 78827087
Anaphylactic shock 96.33 10.72 160 896657 35836 78811735
Vitamin D deficiency 96.13 10.72 366 896451 13913 78833658
Knee arthroplasty 95.79 10.72 822 895995 42426 78805145
Vitamin D decreased 95.44 10.72 283 896534 9442 78838129
Exposure during pregnancy 91.23 10.72 1622 895195 99510 78748061
Urinary tract infection 90.99 10.72 3865 892952 270647 78576924
Hypoglycaemia 90.17 10.72 720 896097 100874 78746697
Sopor 89.95 10.72 145 896672 32865 78814706
Sedation complication 89.64 10.72 32 896785 15637 78831934
Septic shock 89.07 10.72 916 895901 121885 78725686
Miosis 89.04 10.72 33 896784 15756 78831815
Abortion spontaneous 87.84 10.72 601 896216 28906 78818665
Neurotoxicity 87.52 10.72 144 896673 32374 78815197
Product use issue 87.04 10.72 3028 893789 206794 78640777
Anaphylactic reaction 86.65 10.72 568 896249 83175 78764396
Tooth disorder 83.93 10.72 544 896273 25689 78821882
Irritable bowel syndrome 83.70 10.72 1069 895748 61172 78786399
Tachycardia 83.33 10.72 1451 895366 176317 78671254
Low turnover osteopathy 82.97 10.72 107 896710 1879 78845692
Pathogen resistance 82.54 10.72 29 896788 14313 78833258
Hip arthroplasty 82.04 10.72 685 896132 35071 78812500
Cerebral infarction 80.83 10.72 254 896563 45422 78802149
Musculoskeletal pain 80.40 10.72 1607 895210 100747 78746824
Acute graft versus host disease 79.98 10.72 10 896807 10157 78837414
Hepatotoxicity 79.77 10.72 302 896515 51050 78796521
Foot fracture 79.22 10.72 470 896347 21511 78826060
Hyperhidrosis 79.11 10.72 1212 895605 150280 78697291
Substance abuse 78.92 10.72 12 896805 10514 78837057
Weight decreased 78.63 10.72 4811 892006 350387 78497184
Venoocclusive liver disease 78.47 10.72 18 896799 11753 78835818
Muscle injury 78.06 10.72 863 895954 47698 78799873
Posterior reversible encephalopathy syndrome 77.85 10.72 109 896708 26172 78821399
Brain oedema 77.64 10.72 102 896715 25161 78822410
Joint effusion 77.47 10.72 404 896413 17610 78829961
Toxic epidermal necrolysis 77.43 10.72 250 896567 44331 78803240
Drug dependence 76.98 10.72 220 896597 40549 78807022
Respiratory depression 76.58 10.72 120 896697 27510 78820061
Mucormycosis 75.51 10.72 5 896812 8464 78839107
Torsade de pointes 75.00 10.72 64 896753 19248 78828323
Bronchopulmonary aspergillosis 74.88 10.72 84 896733 22210 78825361
Thrombotic microangiopathy 74.54 10.72 70 896747 20099 78827472
Myoclonus 73.97 10.72 123 896694 27537 78820034
Juvenile idiopathic arthritis 73.08 10.72 164 896653 4599 78842972
Renal impairment 72.95 10.72 1291 895526 156492 78691079
Coagulopathy 72.71 10.72 188 896629 35818 78811753
Basal cell carcinoma 71.88 10.72 689 896128 36686 78810885
Aspergillus infection 71.41 10.72 66 896751 19095 78828476
Creatinine renal clearance decreased 71.35 10.72 65 896752 18937 78828634
Tooth fracture 70.71 10.72 287 896530 11243 78836328
Folliculitis 70.63 10.72 942 895875 54438 78793133
Cardiac failure congestive 70.42 10.72 1151 895666 141251 78706320
Drug withdrawal syndrome 70.32 10.72 181 896636 34537 78813034
Foot deformity 70.28 10.72 488 896329 23586 78823985
Sleep disorder due to general medical condition, insomnia type 69.99 10.72 774 896043 42782 78804789
Haematotoxicity 69.91 10.72 44 896773 15475 78832096
Bone giant cell tumour 69.61 10.72 26 896791 34 78847537
Encephalopathy 69.29 10.72 458 896359 66939 78780632
Fracture 69.08 10.72 451 896366 21350 78826221
Aggression 68.41 10.72 317 896500 50641 78796930
Back pain 68.23 10.72 4125 892692 300055 78547516
Intervertebral disc degeneration 67.87 10.72 354 896463 15431 78832140
C-reactive protein abnormal 67.29 10.72 836 895981 47531 78800040
Status epilepticus 67.29 10.72 111 896706 24930 78822641
Unresponsive to stimuli 66.91 10.72 361 896456 55427 78792144
Injection site pruritus 66.85 10.72 749 896068 41534 78806037
Device adhesion issue 66.74 10.72 3 896814 7072 78840499
Dystonia 66.17 10.72 86 896731 21313 78826258
Acute generalised exanthematous pustulosis 66.01 10.72 58 896759 17196 78830375
Sepsis 65.98 10.72 2421 894396 267007 78580564
Spinal osteoarthritis 65.61 10.72 369 896448 16558 78831013
Injection site reaction 65.43 10.72 921 895896 53864 78793707
Asphyxia 65.25 10.72 25 896792 11695 78835876
Psychotic disorder 64.62 10.72 243 896574 41159 78806412
Seizure 63.89 10.72 1625 895192 187209 78660362
Drug level increased 63.67 10.72 230 896587 39421 78808150
Drug intolerance 62.50 10.72 3599 893218 260520 78587051
Palmar-plantar erythrodysaesthesia syndrome 62.41 10.72 179 896638 32955 78814616
Stevens-Johnson syndrome 62.36 10.72 228 896589 38938 78808633
Injection site erythema 62.16 10.72 1230 895587 76967 78770604
Delirium 61.87 10.72 630 896187 83997 78763574
Hyponatraemia 61.64 10.72 1525 895292 176323 78671248
General physical health deterioration 61.43 10.72 3731 893086 271507 78576064
Condition aggravated 61.41 10.72 6485 890332 494639 78352932
Mental status changes 61.06 10.72 471 896346 66488 78781083
Headache 60.58 10.72 8312 888505 645460 78202111
Hyperthermia 60.54 10.72 68 896749 17969 78829602
Loss of consciousness 60.14 10.72 1433 895384 166510 78681061
Pulmonary oedema 60.08 10.72 668 896149 87586 78759985
Hepatocellular injury 59.87 10.72 303 896514 47290 78800281
Coronary artery disease 59.50 10.72 461 896356 65013 78782558
Spinal fracture 59.36 10.72 377 896440 17677 78829894
Suicidal ideation 59.30 10.72 560 896257 75780 78771791
Eosinophilia 59.16 10.72 285 896532 45060 78802511
Fracture delayed union 59.13 10.72 94 896723 2016 78845555
Oropharyngeal pain 59.11 10.72 1630 895187 107723 78739848
Blood cholesterol increased 59.08 10.72 1294 895523 82426 78765145
Hypoaesthesia 58.66 10.72 2522 894295 176830 78670741
Blister 58.28 10.72 1758 895059 117718 78729853
Akathisia 57.82 10.72 39 896778 13220 78834351
Hypersensitivity 57.63 10.72 3550 893267 258689 78588882
Exposure to toxic agent 57.20 10.72 16 896801 9142 78838429
Transplant rejection 57.19 10.72 81 896736 19356 78828215
Ascites 57.12 10.72 558 896259 75004 78772567
Fibromyalgia 56.98 10.72 1029 895788 63311 78784260
Rash maculo-papular 56.68 10.72 383 896434 55695 78791876
Pregnancy 56.68 10.72 505 896312 26346 78821225
Ejection fraction decreased 56.57 10.72 199 896618 34378 78813193
Tumour lysis syndrome 56.42 10.72 115 896702 23824 78823747
Graft versus host disease 55.71 10.72 52 896765 14974 78832597
Angina pectoris 54.98 10.72 348 896469 51384 78796187
Acute graft versus host disease in skin 54.59 10.72 10 896807 7648 78839923
Gait disturbance 53.68 10.72 2851 893966 204655 78642916
Emotional distress 53.44 10.72 249 896568 39720 78807851
Localised infection 53.36 10.72 652 896165 36923 78810648
Bone marrow failure 53.19 10.72 346 896471 50761 78796810
Graft versus host disease in gastrointestinal tract 53.18 10.72 5 896812 6351 78841220
Agranulocytosis 53.12 10.72 293 896524 44737 78802834
Blood pressure diastolic abnormal 53.00 10.72 384 896433 18818 78828753
Inappropriate antidiuretic hormone secretion 52.66 10.72 138 896679 26175 78821396
Colitis ulcerative 52.49 10.72 610 896207 34132 78813439
Blood pressure systolic abnormal 52.35 10.72 353 896464 16894 78830677
Cardiotoxicity 52.04 10.72 37 896780 12202 78835369
Extrapyramidal disorder 51.72 10.72 111 896706 22568 78825003
Influenza 51.63 10.72 1862 894955 127744 78719827
Cerebral haemorrhage 51.50 10.72 408 896409 57265 78790306
Wrong technique in product usage process 51.14 10.72 557 896260 73318 78774253
Colorectal cancer 50.60 10.72 17 896800 8630 78838941
Blood bilirubin increased 50.53 10.72 488 896329 65744 78781827
Toxic skin eruption 50.10 10.72 110 896707 22183 78825388
Anuria 50.00 10.72 100 896717 20863 78826708
Night sweats 49.29 10.72 842 895975 51253 78796318
Synovial cyst 49.14 10.72 234 896583 9831 78837740
Bone density decreased 49.14 10.72 287 896530 13060 78834511
Therapy partial responder 48.75 10.72 75 896742 17322 78830249
Orthostatic hypotension 48.47 10.72 401 896416 55763 78791808
Osteopenia 48.26 10.72 363 896454 18001 78829570
Systemic infection 47.81 10.72 227 896590 9525 78838046
Disability assessment scale score increased 47.50 10.72 114 896703 3344 78844227
Neutrophil count decreased 47.25 10.72 757 896060 93202 78754369
Unintentional medical device removal 47.20 10.72 14 896803 7698 78839873
Electrocardiogram QRS complex prolonged 47.05 10.72 32 896785 10801 78836770
Grip strength decreased 47.04 10.72 413 896404 21456 78826115
Bone disorder 47.00 10.72 372 896445 18741 78828830
Haemodynamic instability 46.75 10.72 77 896740 17305 78830266
Acute myeloid leukaemia 46.45 10.72 184 896633 30701 78816870
Muscle spasticity 46.42 10.72 406 896411 21069 78826502
Gastrointestinal haemorrhage 46.07 10.72 1286 895531 146433 78701138
Bone loss 45.84 10.72 94 896723 2473 78845098
Injection site swelling 45.76 10.72 765 896052 46367 78801204
Haemophagocytic lymphohistiocytosis 45.66 10.72 112 896705 21725 78825846
Proteinuria 45.54 10.72 199 896618 32303 78815268
Cytokine release syndrome 45.38 10.72 229 896588 35769 78811802
Respiratory distress 45.29 10.72 428 896389 57911 78789660
Injection site pain 45.22 10.72 1838 894979 128000 78719571
Bronchitis 45.18 10.72 1848 894969 128796 78718775
International normalised ratio increased 45.17 10.72 675 896142 84046 78763525
Red blood cell count decreased 45.16 10.72 903 895914 56610 78790961
Blood pressure diastolic decreased 44.96 10.72 529 896288 29687 78817884
Rheumatic fever 44.51 10.72 504 896313 28021 78819550
Ill-defined disorder 44.21 10.72 1011 895806 64864 78782707
Chronic graft versus host disease 43.96 10.72 11 896806 6770 78840801
Multiple-drug resistance 43.96 10.72 22 896795 8786 78838785
Hypoxia 43.89 10.72 857 895960 102386 78745185
Hyperglycaemia 43.76 10.72 543 896274 69792 78777779
Tendonitis 43.71 10.72 435 896382 23395 78824176
Nocardiosis 43.68 10.72 6 896811 5673 78841898
Exostosis 43.61 10.72 332 896485 16526 78831045
Stress fracture 43.54 10.72 166 896651 6314 78841257
Exposure via ingestion 43.48 10.72 4 896813 5170 78842401
Ear infection 43.21 10.72 584 896233 33848 78813723
Hypokalaemia 43.14 10.72 1261 895556 142779 78704792
Cognitive disorder 43.07 10.72 541 896276 69385 78778186
Bronchospasm 42.75 10.72 140 896677 24719 78822852
Drug use disorder 42.59 10.72 22 896795 8629 78838942
Multiple sclerosis 42.47 10.72 410 896407 21872 78825699
BK virus infection 42.44 10.72 23 896794 8781 78838790
Immune reconstitution inflammatory syndrome 42.41 10.72 56 896761 13785 78833786
Body height decreased 42.27 10.72 200 896617 8380 78839191
Paradoxical drug reaction 42.27 10.72 14 896803 7171 78840400
Red blood cell sedimentation rate increased 42.18 10.72 739 896078 45203 78802368
Polyarthritis 42.12 10.72 258 896559 11944 78835627
Acute myocardial infarction 42.03 10.72 611 896206 76425 78771146
Sinus tachycardia 41.99 10.72 243 896574 36665 78810906
Infection 41.97 10.72 3209 893608 238503 78609068
Atypical femur fracture 41.75 10.72 141 896676 5048 78842523
Epstein-Barr virus infection 41.50 10.72 61 896756 14355 78833216
Platelet count decreased 41.39 10.72 1778 895039 192886 78654685
Syncope 41.13 10.72 1625 895192 177824 78669747
Blood creatinine increased 40.98 10.72 1380 895437 153677 78693894
Joint stiffness 40.85 10.72 666 896151 40164 78807407
Accidental exposure to product 40.78 10.72 197 896620 31125 78816446
Nephropathy toxic 40.17 10.72 108 896709 20311 78827260
Pyrexia 40.00 10.72 6868 889949 671841 78175730
Thoracic vertebral fracture 39.87 10.72 140 896677 5113 78842458
Toothache 39.82 10.72 371 896446 19599 78827972
Gestational diabetes 39.67 10.72 158 896659 6135 78841436
Upper respiratory tract infection 39.61 10.72 1323 895494 89845 78757726
Gamma-glutamyltransferase increased 39.58 10.72 408 896409 54272 78793299
Blood pressure systolic increased 39.50 10.72 1010 895807 65976 78781595
Wrist fracture 39.24 10.72 249 896568 11672 78835899
Enthesopathy 39.16 10.72 244 896573 11364 78836207
Melaena 39.05 10.72 467 896350 60423 78787148
Polyomavirus-associated nephropathy 38.74 10.72 8 896809 5619 78841952
Accidental overdose 38.68 10.72 273 896544 39308 78808263
Spinal stenosis 38.64 10.72 307 896510 15484 78832087
Ear pain 38.62 10.72 551 896266 32318 78815253
Disorientation 38.55 10.72 486 896331 62290 78785281
Laryngitis 38.26 10.72 310 896507 15729 78831842
Gastrooesophageal reflux disease 38.23 10.72 1484 895333 102762 78744809
Muscle spasms 38.10 10.72 2364 894453 172366 78675205
Bone density abnormal 37.93 10.72 97 896720 2963 78844608
Bladder cancer 37.87 10.72 104 896713 19422 78828149
Abnormal behaviour 37.68 10.72 247 896570 36174 78811397
Heart rate decreased 37.67 10.72 1047 895770 69269 78778302
Haematochezia 37.60 10.72 1270 895547 86375 78761196
Swollen joint count increased 37.56 10.72 409 896408 22518 78825053
Dry eye 37.55 10.72 604 896213 36327 78811244
Metastases to liver 37.49 10.72 177 896640 28137 78819434
Nephrolithiasis 37.37 10.72 823 895994 52468 78795103
Cystitis haemorrhagic 37.36 10.72 29 896788 9143 78838428
Haemodialysis 37.35 10.72 94 896723 18074 78829497
Gait spastic 37.29 10.72 56 896761 1141 78846430
Hypothermia 37.15 10.72 131 896686 22615 78824956
Dental caries 37.13 10.72 244 896573 11576 78835995
Poor venous access 37.11 10.72 339 896478 17810 78829761
Hyperammonaemia 37.03 10.72 42 896775 11051 78836520
Drug ineffective 36.85 10.72 11228 885589 1069685 77777886
Gastroenteritis viral 36.63 10.72 434 896383 24397 78823174
Vomiting 36.48 10.72 6764 890053 659064 78188507
Anhedonia 36.46 10.72 70 896747 14828 78832743
Toxic encephalopathy 36.39 10.72 45 896772 11395 78836176
Appendicolith 36.16 10.72 26 896791 8525 78839046
Hypercalcaemia 35.94 10.72 620 896197 37810 78809761
Gastrointestinal disorder 35.91 10.72 1700 895117 120505 78727066
Leukopenia 35.90 10.72 1016 895801 115497 78732074
Inflammation 35.89 10.72 1341 895476 92412 78755159
Jaundice 35.83 10.72 405 896412 52944 78794627
Face oedema 35.46 10.72 179 896638 27957 78819614
Endophthalmitis 35.31 10.72 14 896803 6414 78841157
Renal injury 35.25 10.72 87 896730 16840 78830731
Joint injury 35.12 10.72 521 896296 30814 78816757
Pulseless electrical activity 35.12 10.72 66 896751 14094 78833477
Device use error 35.04 10.72 18 896799 7083 78840488
Pneumatosis intestinalis 35.03 10.72 14 896803 6383 78841188
Cholestasis 34.83 10.72 396 896421 51713 78795858
Febrile bone marrow aplasia 34.72 10.72 58 896759 12962 78834609
Second primary malignancy 34.62 10.72 68 896749 14282 78833289
Pleural effusion 34.47 10.72 1310 895507 143952 78703619
Acute coronary syndrome 34.32 10.72 122 896695 21011 78826560
Hemiplegia 34.16 10.72 73 896744 14866 78832705
Adenovirus infection 34.03 10.72 27 896790 8420 78839151
Rhinorrhoea 33.82 10.72 1107 895710 74967 78772604
Rash 33.80 10.72 7176 889641 571182 78276389
Pulmonary alveolar haemorrhage 33.45 10.72 48 896769 11409 78836162
Diffuse large B-cell lymphoma recurrent 33.43 10.72 4 896813 4203 78843368
Mania 33.40 10.72 100 896717 18160 78829411
Intentional product use issue 33.34 10.72 2059 894758 150053 78697518
Nasal congestion 33.28 10.72 1111 895706 75441 78772130
Injection site bruising 33.27 10.72 647 896170 40355 78807216
Hepatitis cholestatic 33.11 10.72 66 896751 13786 78833785
Malignant melanoma 33.07 10.72 281 896536 14460 78833111
Breast cancer stage I 33.04 10.72 17 896800 6683 78840888
Pancreatitis 32.99 10.72 557 896260 68018 78779553
Joint laxity 32.98 10.72 78 896739 2266 78845305
Cystitis 32.85 10.72 801 896016 51931 78795640
Joint destruction 32.84 10.72 143 896674 5782 78841789
Arrhythmia 32.72 10.72 488 896329 60784 78786787
Respiratory acidosis 32.63 10.72 47 896770 11153 78836418
Cyanosis 32.43 10.72 159 896658 25023 78822548
Restlessness 32.39 10.72 350 896467 46142 78801429
Pneumocystis jirovecii pneumonia 32.36 10.72 223 896594 32285 78815286
Myocardial ischaemia 32.36 10.72 162 896655 25357 78822214
Latent tuberculosis 32.36 10.72 97 896720 3256 78844315
Cough 32.36 10.72 4651 892166 362138 78485433
Blood lactic acid increased 31.96 10.72 59 896758 12685 78834886
Breast cancer 31.95 10.72 546 896271 33235 78814336
Transplant dysfunction 31.81 10.72 21 896796 7200 78840371
Temperature regulation disorder 31.74 10.72 13 896804 5840 78841731
Full blood count decreased 31.67 10.72 450 896367 26369 78821202
Catatonia 31.65 10.72 31 896786 8725 78838846
Drug abuser 31.58 10.72 14 896803 5999 78841572
Tenosynovitis 31.54 10.72 290 896527 15264 78832307
Ileus paralytic 31.49 10.72 37 896780 9583 78837988
Stress cardiomyopathy 31.42 10.72 48 896769 11118 78836453
Caesarean section 31.39 10.72 245 896572 12290 78835281
Blood pressure increased 31.38 10.72 2773 894044 208587 78638984
Nodule 31.36 10.72 396 896421 22598 78824973
Cytomegalovirus infection reactivation 31.34 10.72 31 896786 8685 78838886
Acute chest syndrome 31.30 10.72 60 896757 1501 78846070
Tenderness 30.91 10.72 404 896413 23238 78824333
Carpal tunnel syndrome 30.90 10.72 346 896471 19182 78828389
Hyperbilirubinaemia 30.89 10.72 156 896661 24362 78823209
Hepatitis B reactivation 30.87 10.72 15 896802 6093 78841478
Acidosis 30.83 10.72 116 896701 19646 78827925
Hepatitis fulminant 30.82 10.72 22 896795 7240 78840331
Angina unstable 30.60 10.72 90 896727 16437 78831134
Haemorrhage intracranial 30.58 10.72 171 896646 26022 78821549
Skin toxicity 30.55 10.72 29 896788 8285 78839286
Cytopenia 30.29 10.72 122 896695 20261 78827310
Stomatitis 30.24 10.72 1976 894841 144781 78702790
Loss of personal independence in daily activities 30.14 10.72 1427 895390 101153 78746418
Cytomegalovirus chorioretinitis 30.09 10.72 12 896805 5478 78842093
Cataract 29.99 10.72 913 895904 61207 78786364
Pneumonia aspiration 29.96 10.72 551 896266 66416 78781155
Heparin-induced thrombocytopenia 29.85 10.72 39 896778 9643 78837928
Accidental death 29.75 10.72 6 896811 4285 78843286
Cyst 29.57 10.72 261 896556 13579 78833992
Alcohol interaction 29.55 10.72 9 896808 4865 78842706
Muscle rigidity 29.55 10.72 119 896698 19763 78827808
Multiple fractures 29.17 10.72 172 896645 7854 78839717
Enterocolitis 29.12 10.72 76 896741 14436 78833135
Aspartate aminotransferase increased 29.11 10.72 1268 895549 137373 78710198
Blood alkaline phosphatase increased 29.06 10.72 522 896295 63142 78784429
Human herpesvirus 6 infection 29.00 10.72 12 896805 5358 78842213
Drug-induced liver injury 28.96 10.72 546 896271 65571 78782000
Purpura 28.94 10.72 117 896700 19410 78828161
Myopathy 28.75 10.72 126 896691 20437 78827134
Tubulointerstitial nephritis 28.62 10.72 283 896534 37952 78809619
Venoocclusive disease 28.54 10.72 8 896809 4565 78843006
Withdrawal syndrome 28.35 10.72 181 896636 26673 78820898
Vascular stent thrombosis 28.35 10.72 4 896813 3706 78843865
Mouth ulceration 28.22 10.72 597 896220 37797 78809774
Memory impairment 28.04 10.72 1531 895286 110203 78737368
Oral herpes 27.91 10.72 449 896368 27005 78820566
Hallucination, visual 27.64 10.72 235 896582 32494 78815077
Drug screen positive 27.57 10.72 17 896800 6046 78841525
Vasoplegia syndrome 27.53 10.72 4 896813 3626 78843945
Fracture nonunion 27.49 10.72 56 896761 1466 78846105
Sexual dysfunction 27.46 10.72 28 896789 7735 78839836
Device expulsion 27.46 10.72 174 896643 25687 78821884
Injection site rash 27.46 10.72 316 896501 17638 78829933
Skin cancer 27.32 10.72 274 896543 14766 78832805
Erythema multiforme 27.28 10.72 104 896713 17547 78830024
Dermatitis exfoliative 27.28 10.72 50 896767 10779 78836792
Blood pressure decreased 27.27 10.72 881 895936 98585 78748986
Bradyphrenia 26.91 10.72 49 896768 10591 78836980
Pulmonary embolism 26.83 10.72 1618 895199 170036 78677535
Jaundice cholestatic 26.77 10.72 54 896763 11230 78836341
Fear 26.51 10.72 142 896675 21844 78825727
Ileus 26.49 10.72 179 896638 26032 78821539
Increased tendency to bruise 26.47 10.72 205 896612 10259 78837312
Anaemia 26.39 10.72 4501 892316 440514 78407057
Neck pain 26.34 10.72 1068 895749 74349 78773222
Graft versus host disease in skin 26.30 10.72 18 896799 6055 78841516
Burning sensation 26.27 10.72 854 895963 57778 78789793
Metabolic disorder 26.21 10.72 39 896778 9131 78838440
Device difficult to use 26.18 10.72 71 896746 13314 78834257
Cross sensitivity reaction 26.14 10.72 5 896812 3707 78843864
Paranoia 26.01 10.72 121 896696 19311 78828260
Pruritus genital 25.94 10.72 9 896808 4477 78843094
Folate deficiency 25.89 10.72 90 896727 3270 78844301
Hypomania 25.80 10.72 28 896789 7516 78840055
Neck deformity 25.71 10.72 61 896756 1776 78845795
Tongue disorder 25.58 10.72 255 896562 13720 78833851
Limb discomfort 25.53 10.72 515 896302 32335 78815236
Pneumothorax 25.46 10.72 200 896617 28123 78819448
Maternal exposure before pregnancy 25.36 10.72 107 896710 4266 78843305
Acute graft versus host disease in intestine 25.35 10.72 7 896810 4034 78843537
Analgesic drug level increased 25.31 10.72 3 896814 3175 78844396
Dysarthria 25.31 10.72 573 896244 67049 78780522
Dermatitis acneiform 25.30 10.72 46 896771 9947 78837624
Surgery 25.23 10.72 513 896304 32253 78815318
Cytomegalovirus viraemia 25.08 10.72 68 896749 12753 78834818
Virologic failure 24.95 10.72 8 896809 4183 78843388
Hepatic encephalopathy 24.94 10.72 164 896653 24002 78823569
Alanine aminotransferase increased 24.94 10.72 1535 895282 161035 78686536
Adverse event 24.94 10.72 869 895948 59345 78788226
Peripheral sensory neuropathy 24.84 10.72 70 896747 12963 78834608
Live birth 24.80 10.72 321 896496 18423 78829148
C-reactive protein increased 24.59 10.72 1726 895091 127301 78720270
Meniscus injury 24.57 10.72 145 896672 6623 78840948
Lumbar vertebral fracture 24.57 10.72 149 896668 6873 78840698
Pulmonary haemorrhage 24.54 10.72 84 896733 14633 78832938
Circulatory collapse 24.50 10.72 288 896529 37380 78810191
Left ventricular dysfunction 24.50 10.72 123 896694 19238 78828333
Epstein-Barr virus associated lymphoproliferative disorder 24.36 10.72 5 896812 3527 78844044
Gastric haemorrhage 24.36 10.72 87 896730 14963 78832608
Metastases to central nervous system 24.34 10.72 98 896719 16277 78831294
Limb injury 24.32 10.72 467 896350 29061 78818510
Alanine aminotransferase abnormal 24.28 10.72 177 896640 8690 78838881
Sciatica 24.23 10.72 516 896301 32706 78814865
Dental implantation 24.18 10.72 31 896786 541 78847030
Pancreatitis acute 24.15 10.72 402 896415 49202 78798369
Blood lactate dehydrogenase increased 24.14 10.72 303 896514 38867 78808704
Abortion incomplete 24.14 10.72 3 896814 3061 78844510
Relapsing-remitting multiple sclerosis 24.09 10.72 53 896764 1466 78846105
Cerebrovascular accident 24.05 10.72 1465 895352 153827 78693744
Generalised tonic-clonic seizure 24.04 10.72 348 896469 43562 78804009
Mobility decreased 23.92 10.72 1638 895179 120537 78727034
Gastric cancer 23.90 10.72 49 896768 10130 78837441
Humerus fracture 23.86 10.72 183 896634 9130 78838441
Vitamin D increased 23.85 10.72 32 896785 585 78846986
Hip fracture 23.82 10.72 482 896335 30279 78817292
Rotator cuff syndrome 23.81 10.72 253 896564 13842 78833729
Potentiating drug interaction 23.78 10.72 39 896778 8780 78838791
Blood parathyroid hormone increased 23.77 10.72 89 896728 3356 78844215
Bone erosion 23.76 10.72 306 896511 17541 78830030
Psychomotor hyperactivity 23.70 10.72 103 896714 16746 78830825
Hyperparathyroidism 23.68 10.72 85 896732 3139 78844432
Joint dislocation 23.65 10.72 293 896524 16646 78830925
Hepatic cancer 23.62 10.72 52 896765 10477 78837094
Pulmonary congestion 23.60 10.72 193 896624 26907 78820664
Frequent bowel movements 23.59 10.72 465 896352 29074 78818497
Musculoskeletal discomfort 23.50 10.72 333 896484 19502 78828069
Type I hypersensitivity 23.48 10.72 10 896807 4388 78843183
Jaw disorder 23.44 10.72 115 896702 4891 78842680
Scoliosis 23.40 10.72 154 896663 7310 78840261
Squamous cell carcinoma of skin 23.29 10.72 251 896566 13782 78833789
Rheumatoid nodule 23.22 10.72 299 896518 17139 78830432
Oral infection 23.18 10.72 126 896691 5581 78841990
Herpes zoster 23.07 10.72 1274 895543 91809 78755762
Accidental exposure to product by child 22.72 10.72 3 896814 2923 78844648
Thyroid mass 22.65 10.72 97 896720 3893 78843678
Upper limb fracture 22.65 10.72 305 896512 17662 78829909
Blood glucose increased 22.62 10.72 1059 895758 113916 78733655
Nervous system disorder 22.60 10.72 193 896624 26663 78820908
Aplasia 22.60 10.72 33 896784 7787 78839784
Cystic fibrosis 22.55 10.72 95 896722 3785 78843786
Mucosal inflammation 22.54 10.72 662 896155 74918 78772653
Diabetic ketoacidosis 22.54 10.72 260 896557 33862 78813709
Sleep terror 22.45 10.72 11 896806 4447 78843124
Cardiac failure acute 22.41 10.72 123 896694 18806 78828765
Anti-neutrophil cytoplasmic antibody positive vasculitis 22.41 10.72 7 896810 3722 78843849
Mucous stools 22.35 10.72 116 896701 5046 78842525
Subarachnoid haemorrhage 22.34 10.72 172 896645 24293 78823278
Mitochondrial toxicity 22.34 10.72 4 896813 3110 78844461
Needle fatigue 22.33 10.72 38 896779 864 78846707
Smear cervix abnormal 22.28 10.72 71 896746 2465 78845106
Tardive dyskinesia 22.27 10.72 54 896763 10517 78837054
Product quality issue 22.27 10.72 259 896558 33681 78813890
Aphthous ulcer 22.25 10.72 289 896528 16600 78830971
Acute lung injury 22.20 10.72 4 896813 3096 78844475
Gingival recession 22.16 10.72 46 896771 1221 78846350
Hallucination, auditory 22.09 10.72 139 896678 20554 78827017
Pulmonary fibrosis 22.01 10.72 651 896166 43461 78804110
Haemorrhage 21.99 10.72 820 895997 90298 78757273
Leukocytosis 21.88 10.72 350 896467 43105 78804466
Transaminases increased 21.84 10.72 430 896387 51313 78796258
Upper respiratory tract inflammation 21.82 10.72 9 896808 4026 78843545
Abdominal pain upper 21.79 10.72 2855 893962 220964 78626607
Reversible cerebral vasoconstriction syndrome 21.78 10.72 4 896813 3053 78844518
Viral infection 21.51 10.72 635 896182 42381 78805190
Joint range of motion decreased 21.47 10.72 508 896309 32774 78814797
Ankle fracture 21.37 10.72 288 896529 16681 78830890
Disability 21.33 10.72 290 896527 16830 78830741
Hypoalbuminaemia 21.25 10.72 146 896671 21151 78826420
Intraductal proliferative breast lesion 21.21 10.72 69 896748 2422 78845149
Nasal polyps 21.10 10.72 31 896786 7296 78840275
Toxic anterior segment syndrome 21.07 10.72 3 896814 2761 78844810
Hallucination 21.06 10.72 770 896047 84975 78762596
Blood pressure diastolic increased 20.94 10.72 253 896564 14289 78833282
Aortic valve stenosis 20.91 10.72 116 896701 5178 78842393
Hypercalciuria 20.87 10.72 28 896789 512 78847059
Irritability 20.84 10.72 331 896486 40813 78806758
Anaemia postoperative 20.79 10.72 57 896760 1817 78845754
Product prescribing error 20.67 10.72 655 896162 44158 78803413
Eye infection 20.62 10.72 215 896602 11705 78835866
Strongyloidiasis 20.59 10.72 9 896808 3889 78843682
Palmoplantar keratoderma 20.57 10.72 8 896809 3708 78843863
Tremor 20.49 10.72 1640 895177 168443 78679128
Ligament rupture 20.43 10.72 84 896733 3310 78844261
Hypomagnesaemia 20.36 10.72 388 896429 46523 78801048
No adverse event 20.28 10.72 295 896522 36897 78810674
Tibia fracture 20.20 10.72 116 896701 5245 78842326
Injection site urticaria 20.18 10.72 227 896590 12599 78834972
Rash pruritic 20.10 10.72 992 895825 70637 78776934
Anal fissure 20.09 10.72 152 896665 7551 78840020
Bone pain 20.07 10.72 792 896025 54950 78792621
Hyperprolactinaemia 20.06 10.72 14 896803 4662 78842909
Coronary arterial stent insertion 20.05 10.72 23 896794 6021 78841550
Skin papilloma 20.03 10.72 124 896693 5762 78841809
Immune-mediated myositis 19.97 10.72 7 896810 3460 78844111
Lupus-like syndrome 19.91 10.72 241 896576 13616 78833955
Rotator cuff repair 19.88 10.72 56 896761 1814 78845757
Lower respiratory tract infection viral 19.84 10.72 43 896774 1177 78846394
Right atrial hypertrophy 19.78 10.72 33 896784 738 78846833
Atrial tachycardia 19.75 10.72 31 896786 7102 78840469
Lethargy 19.75 10.72 731 896086 80561 78767010
Milk-alkali syndrome 19.71 10.72 47 896770 1373 78846198
Inadequate analgesia 19.67 10.72 14 896803 4615 78842956
Cardiac failure chronic 19.64 10.72 62 896755 11073 78836498
Knee operation 19.60 10.72 123 896694 5743 78841828
Intestinal stenosis 19.59 10.72 89 896728 3665 78843906
Wheelchair user 19.52 10.72 127 896690 6005 78841566
Cellulitis 19.42 10.72 1451 895366 107609 78739962
Red blood cell sedimentation rate 19.42 10.72 118 896699 5447 78842124
Metastases to lung 19.39 10.72 122 896695 18041 78829530
Invasive ductal breast carcinoma 19.35 10.72 123 896694 5769 78841802
Renal tubular necrosis 19.30 10.72 184 896633 24855 78822716
Multimorbidity 19.29 10.72 47 896770 1392 78846179
Diverticulum intestinal 19.29 10.72 164 896653 8441 78839130
Acute myeloid leukaemia recurrent 19.20 10.72 7 896810 3376 78844195
Nephrotic syndrome 19.17 10.72 63 896754 11111 78836460
Coronary artery bypass 19.12 10.72 24 896793 6038 78841533
Metastases to lymph nodes 18.97 10.72 57 896760 10340 78837231
Pharyngitis streptococcal 18.89 10.72 194 896623 10520 78837051
Osteoporotic fracture 18.86 10.72 96 896721 4144 78843427
Amylase increased 18.68 10.72 64 896753 11145 78836426
Finger deformity 18.67 10.72 146 896671 7328 78840243
Gingival disorder 18.64 10.72 86 896731 3565 78844006
Neutropenic colitis 18.63 10.72 22 896795 5685 78841886
Product monitoring error 18.54 10.72 167 896650 8739 78838832
Disease recurrence 18.48 10.72 367 896450 43742 78803829
Neck mass 18.41 10.72 98 896719 4306 78843265
Mean cell volume increased 18.39 10.72 127 896690 6126 78841445
Lower limb fracture 18.39 10.72 365 896452 22850 78824721
Fibula fracture 18.36 10.72 86 896731 3588 78843983
Tooth abscess 18.35 10.72 270 896547 15940 78831631
Ileal stenosis 18.28 10.72 64 896753 2334 78845237
Ketoacidosis 18.28 10.72 38 896779 7816 78839755
Influenza like illness 18.27 10.72 984 895833 70723 78776848
Post procedural infection 18.15 10.72 202 896615 11182 78836389
Distributive shock 18.13 10.72 4 896813 2683 78844888
Hypoxic-ischaemic encephalopathy 18.06 10.72 38 896779 7782 78839789
Obstructive airways disorder 18.05 10.72 247 896570 31212 78816359
Tooth infection 18.04 10.72 305 896512 18527 78829044
Atrioventricular block complete 18.03 10.72 111 896706 16499 78831072
Dyspnoea 18.02 10.72 9058 887759 847967 77999604
Sinus bradycardia 18.02 10.72 189 896628 25058 78822513
Hepatitis B 18.00 10.72 42 896775 8290 78839281
Drug eruption 17.97 10.72 367 896450 43568 78804003
Acute lymphocytic leukaemia recurrent 17.93 10.72 16 896801 4708 78842863
Systemic mycosis 17.93 10.72 4 896813 2662 78844909
Limb deformity 17.92 10.72 84 896733 3506 78844065
Hypertonic bladder 17.91 10.72 94 896723 4107 78843464
Urinary retention 17.90 10.72 492 896325 56138 78791433
Bursitis 17.89 10.72 529 896288 35315 78812256
Hepatic cytolysis 17.88 10.72 207 896610 26944 78820627
Spondylolisthesis 17.88 10.72 77 896740 3098 78844473
Carotid artery thrombosis 17.87 10.72 6 896811 3047 78844524
Shock haemorrhagic 17.87 10.72 142 896675 19918 78827653
Inappropriate schedule of product administration 17.84 10.72 1740 895077 131888 78715683
Muscle strain 17.81 10.72 175 896642 9380 78838191
Back disorder 17.80 10.72 204 896613 11374 78836197
Systemic candida 17.76 10.72 30 896787 6676 78840895
Arthropod bite 17.71 10.72 159 896658 8312 78839259
Arthritis infective 17.68 10.72 156 896661 8115 78839456
Tonsillar ulcer 17.66 10.72 23 896794 408 78847163
Intraductal papillary mucinous neoplasm 17.66 10.72 32 896785 766 78846805
Intervertebral disc protrusion 17.59 10.72 368 896449 23253 78824318
Cholecystitis chronic 17.59 10.72 55 896762 9851 78837720
Ventricular hypokinesia 17.57 10.72 50 896767 9229 78838342
Prostate cancer stage IV 17.54 10.72 3 896814 2411 78845160
Cardiopulmonary failure 17.49 10.72 31 896786 6770 78840801
Wrong product administered 17.48 10.72 48 896769 8964 78838607
Kidney transplant rejection 17.42 10.72 58 896759 10188 78837383
Haemorrhage subcutaneous 17.41 10.72 17 896800 4792 78842779
Visual acuity reduced 17.40 10.72 230 896587 29239 78818332
Bacteraemia 17.33 10.72 262 896555 32562 78815009
Treatment failure 17.26 10.72 2180 894637 168306 78679265
Pseudomembranous colitis 17.24 10.72 21 896796 5353 78842218
Pollakiuria 17.10 10.72 545 896272 36772 78810799
Bradypnoea 17.04 10.72 26 896791 6026 78841545
Persecutory delusion 17.04 10.72 18 896799 4891 78842680
Hypoglycaemic coma 17.03 10.72 17 896800 4743 78842828
Ankylosing spondylitis 16.99 10.72 211 896606 11994 78835577
Blood urea increased 16.98 10.72 418 896399 48372 78799199
Linear IgA disease 16.91 10.72 7 896810 3125 78844446
Injection site warmth 16.91 10.72 247 896570 14560 78833011
Kounis syndrome 16.86 10.72 14 896803 4268 78843303
Tenosynovitis stenosans 16.84 10.72 74 896743 3004 78844567
Pseudomonas infection 16.80 10.72 152 896665 20751 78826820
Spinal disorder 16.79 10.72 183 896634 10077 78837494
Prothrombin time prolonged 16.78 10.72 116 896701 16783 78830788
Hyperlactacidaemia 16.78 10.72 23 896794 5572 78841999
Personality disorder 16.74 10.72 27 896790 6119 78841452
Sudden death 16.69 10.72 167 896650 22344 78825227
Blood iron decreased 16.67 10.72 255 896562 15179 78832392
Anticholinergic syndrome 16.60 10.72 10 896807 3601 78843970
Migraine 16.59 10.72 1170 895647 86323 78761248
Dyspepsia 16.59 10.72 1429 895388 107258 78740313
Musculoskeletal disorder 16.58 10.72 336 896481 21112 78826459
Road traffic accident 16.57 10.72 624 896193 43040 78804531
Neurologic neglect syndrome 16.52 10.72 6 896811 2901 78844670
Hyperaesthesia teeth 16.51 10.72 52 896765 1794 78845777
Groin pain 16.47 10.72 222 896595 12858 78834713
Flatulence 16.32 10.72 611 896206 42113 78805458
Joint noise 16.32 10.72 88 896729 3886 78843685
Therapy cessation 16.28 10.72 545 896272 37017 78810554
Breast disorder 16.26 10.72 56 896761 2025 78845546
Psychomotor skills impaired 16.24 10.72 21 896796 5216 78842355
Dehydration 16.24 10.72 2496 894321 245691 78601880
Atrioventricular block 16.21 10.72 92 896725 13949 78833622
Nephritic syndrome 16.21 10.72 22 896795 407 78847164
Body temperature decreased 16.21 10.72 475 896342 31670 78815901
Compartment syndrome 16.15 10.72 20 896797 5062 78842509
Spinal pain 16.12 10.72 253 896564 15139 78832432
Edentulous 16.12 10.72 17 896800 238 78847333
Klebsiella infection 16.06 10.72 107 896710 15613 78831958
Fistula 16.04 10.72 219 896598 12721 78834850
Hypogammaglobulinaemia 15.98 10.72 83 896734 12868 78834703
Blood calcium increased 15.88 10.72 183 896634 10217 78837354
Large intestinal stenosis 15.88 10.72 69 896748 2787 78844784
Osteomyelitis 15.85 10.72 483 896334 32382 78815189
Obesity 15.83 10.72 512 896305 34613 78812958
Parathyroid tumour benign 15.83 10.72 31 896786 788 78846783
Endodontic procedure 15.82 10.72 67 896750 2676 78844895
Retinal haemorrhage 15.76 10.72 44 896773 8173 78839398
Dyskinesia 15.75 10.72 383 896434 44390 78803181
Spinal operation 15.74 10.72 147 896670 7770 78839801
Ulcer 15.69 10.72 445 896372 29527 78818044
Nerve compression 15.68 10.72 166 896651 9073 78838498
Pre-eclampsia 15.68 10.72 134 896683 6907 78840664
Malignant mediastinal neoplasm 15.66 10.72 43 896774 1372 78846199
Blepharospasm 15.57 10.72 116 896701 5735 78841836
Leukoencephalopathy 15.55 10.72 42 896775 7887 78839684
Hypertransaminasaemia 15.52 10.72 75 896742 11849 78835722
Device leakage 15.49 10.72 66 896751 10790 78836781
Hyperuricaemia 15.48 10.72 74 896743 11725 78835846
Gastrointestinal infection 15.47 10.72 197 896620 11264 78836307
Skin laceration 15.44 10.72 431 896386 28531 78819040
Metastases to bone 15.41 10.72 188 896629 24239 78823332
Brain death 15.41 10.72 25 896792 5652 78841919
Disinhibition 15.39 10.72 5 896812 2593 78844978
Lumbar spinal stenosis 15.37 10.72 107 896710 5175 78842396
Haematocrit decreased 15.35 10.72 840 895977 60472 78787099
Pelvic fracture 15.31 10.72 207 896610 11997 78835574
Isosthenuria 15.31 10.72 12 896805 111 78847460
Intestinal ischaemia 15.29 10.72 87 896730 13183 78834388
Micturition urgency 15.29 10.72 213 896604 12428 78835143
Capillary leak syndrome 15.25 10.72 13 896804 3912 78843659
Periodontal disease 15.21 10.72 51 896766 1819 78845752
Right ventricular failure 15.15 10.72 180 896637 23317 78824254
Ligament sprain 15.14 10.72 224 896593 13240 78834331
Hepatic necrosis 15.13 10.72 52 896765 9048 78838523
Prescribed underdose 15.12 10.72 437 896380 29077 78818494
Cardiomyopathy 15.08 10.72 230 896587 28544 78819027
Periprosthetic fracture 15.07 10.72 26 896791 598 78846973
Depressive symptom 15.01 10.72 31 896786 6392 78841179
Neuropathy peripheral 15.00 10.72 1376 895441 139929 78707642
Oral pain 14.99 10.72 466 896351 31332 78816239
Polyhydramnios 14.97 10.72 48 896769 1672 78845899
Bacterial sepsis 14.92 10.72 45 896772 8153 78839418
Appendix disorder 14.90 10.72 48 896769 1676 78845895
Tooth loss 14.90 10.72 133 896684 6942 78840629
Wrong patient received product 14.86 10.72 18 896799 4600 78842971
Osteonecrosis of jaw 14.83 10.72 611 896206 42615 78804956
Faecal calprotectin increased 14.83 10.72 110 896707 5431 78842140
Hepatitis acute 14.80 10.72 108 896709 15434 78832137
Pemphigoid 14.78 10.72 106 896711 15209 78832362
Oliguria 14.73 10.72 115 896702 16194 78831377
Immune effector cell-associated neurotoxicity syndrome 14.73 10.72 27 896790 5821 78841750
Dry mouth 14.67 10.72 1165 895652 86854 78760717
Methaemoglobinaemia 14.59 10.72 25 896792 5532 78842039
Hyperparathyroidism secondary 14.59 10.72 64 896753 2596 78844975
Injection site mass 14.56 10.72 313 896504 19871 78827700
Gene mutation 14.51 10.72 6 896811 2680 78844891
Lip dry 14.51 10.72 249 896568 15169 78832402
Inflammatory bowel disease 14.46 10.72 111 896706 5540 78842031
Polyuria 14.45 10.72 104 896713 14910 78832661
Liver disorder 14.44 10.72 666 896151 71751 78775820
Normal newborn 14.41 10.72 132 896685 6940 78840631
Arteriospasm coronary 14.39 10.72 34 896783 6682 78840889
Generalised oedema 14.39 10.72 184 896633 23525 78824046
Ventricular arrhythmia 14.38 10.72 51 896766 8789 78838782
Renal cyst haemorrhage 14.37 10.72 27 896790 665 78846906
Vitamin B complex deficiency 14.35 10.72 29 896788 755 78846816
Disturbance in social behaviour 14.34 10.72 21 896796 4949 78842622
Taste disorder 14.34 10.72 254 896563 15569 78832002
Hypophosphatasia 14.33 10.72 9 896808 56 78847515
Synovial disorder 14.33 10.72 52 896765 1931 78845640
Coronary artery stenosis 14.30 10.72 82 896735 12402 78835169
Peripheral venous disease 14.28 10.72 255 896562 15654 78831917
Pruritus 14.27 10.72 4798 892019 389850 78457721
Diabetes insipidus 14.27 10.72 23 896794 5214 78842357
Ingrown hair 14.27 10.72 28 896789 713 78846858
Oral disorder 14.26 10.72 175 896642 9920 78837651
Ischaemic cardiomyopathy 14.18 10.72 42 896775 7653 78839918
Hernia 14.12 10.72 270 896547 16789 78830782
Soft tissue mass 14.11 10.72 39 896778 1249 78846322
Rash morbilliform 14.11 10.72 30 896787 6120 78841451
Bladder hypertrophy 14.04 10.72 26 896791 633 78846938
Gingival pain 14.04 10.72 159 896658 8839 78838732
Secondary progressive multiple sclerosis 14.04 10.72 41 896776 1356 78846215
Premature rupture of membranes 14.02 10.72 86 896731 3983 78843588
Homicidal ideation 13.99 10.72 11 896806 3446 78844125
Corneal oedema 13.92 10.72 6 896811 2614 78844957
Patellofemoral pain syndrome 13.89 10.72 23 896794 511 78847060
Hyperreflexia 13.89 10.72 48 896769 8337 78839234
Lipodystrophy acquired 13.77 10.72 17 896800 4308 78843263
Ingrowing nail 13.76 10.72 66 896751 2781 78844790
Victim of child abuse 13.72 10.72 32 896785 921 78846650
Candida infection 13.68 10.72 326 896491 37888 78809683
Pneumonia bacterial 13.68 10.72 145 896672 19186 78828385
Fungaemia 13.64 10.72 19 896798 4572 78842999
Collagen-vascular disease 13.62 10.72 10 896807 83 78847488
Urge incontinence 13.61 10.72 35 896782 1073 78846498
Uterine disorder 13.58 10.72 55 896762 2152 78845419
Hepatitis 13.56 10.72 501 896316 55226 78792345
Acrochordon 13.56 10.72 34 896783 1026 78846545
Cholangitis 13.54 10.72 86 896731 12690 78834881
Osteomalacia 13.52 10.72 42 896775 1438 78846133
Clavicle fracture 13.50 10.72 90 896727 4291 78843280
Chondropathy 13.45 10.72 60 896757 2452 78845119
Abscess oral 13.40 10.72 42 896775 1445 78846126
Blood parathyroid hormone decreased 13.34 10.72 179 896638 10357 78837214
Myelodysplastic syndrome 13.34 10.72 250 896567 30051 78817520
Propofol infusion syndrome 13.28 10.72 3 896814 1980 78845591
Hypercholesterolaemia 13.25 10.72 347 896470 22748 78824823
Spinal compression fracture 13.22 10.72 266 896551 16692 78830879
Hypoacusis 13.21 10.72 438 896379 29712 78817859
Gait inability 13.18 10.72 799 896018 58118 78789453
Congestive cardiomyopathy 13.16 10.72 78 896739 11702 78835869
Pupillary reflex impaired 13.16 10.72 11 896806 3342 78844229
Immunisation 13.14 10.72 4 896813 2163 78845408
Plantar fasciitis 13.13 10.72 75 896742 3385 78844186
Viraemia 13.11 10.72 8 896809 2861 78844710
Breast cancer stage II 13.10 10.72 47 896770 8073 78839498
Hand fracture 13.10 10.72 117 896700 6108 78841463
Prescription drug used without a prescription 13.07 10.72 16 896801 4069 78843502
Maternal exposure during breast feeding 13.06 10.72 64 896753 2721 78844850
Kidney infection 13.03 10.72 330 896487 21521 78826050
Priapism 13.03 10.72 19 896798 4486 78843085
Loose body in joint 13.01 10.72 38 896779 1257 78846314
Hypersomnia 13.00 10.72 346 896471 22740 78824831
Enterococcal infection 12.97 10.72 113 896704 15547 78832024
Nocturia 12.89 10.72 221 896596 13460 78834111
Pancreatic failure 12.89 10.72 44 896773 1584 78845987
Dry throat 12.87 10.72 138 896679 7568 78840003
Rash erythematous 12.82 10.72 525 896292 57244 78790327
Cerebral haematoma 12.80 10.72 46 896771 7896 78839675
Exostosis of jaw 12.79 10.72 37 896780 1217 78846354
Product dose omission in error 12.79 10.72 139 896678 7649 78839922
Wound infection 12.78 10.72 357 896460 23634 78823937
Nightmare 12.78 10.72 209 896608 25652 78821919
Hepatitis C 12.78 10.72 80 896737 11845 78835726
Aortic arteriosclerosis 12.77 10.72 155 896662 8763 78838808
Urinary hesitation 12.76 10.72 87 896730 4179 78843392
Electrocardiogram ST segment depression 12.76 10.72 22 896795 4856 78842715
Subdural haematoma 12.73 10.72 263 896554 31171 78816400
Infection reactivation 12.72 10.72 7 896810 2650 78844921
Foot operation 12.71 10.72 109 896708 5624 78841947
Myocarditis 12.70 10.72 170 896647 21563 78826008
Cold type haemolytic anaemia 12.64 10.72 18 896799 349 78847222
Total lung capacity increased 12.63 10.72 5 896812 2293 78845278
Breast feeding 12.63 10.72 26 896791 686 78846885
Scleritis 12.54 10.72 88 896729 4268 78843303
Disturbance in attention 12.52 10.72 456 896361 50345 78797226
Rectocele 12.50 10.72 24 896793 601 78846970
Incorrect route of product administration 12.50 10.72 298 896519 34631 78812940
Cartilage injury 12.48 10.72 42 896775 1501 78846070
Asthma 12.47 10.72 1329 895488 133766 78713805
Onychomycosis 12.46 10.72 145 896672 8116 78839455
Oculogyric crisis 12.45 10.72 9 896808 2943 78844628
JC polyomavirus test positive 12.42 10.72 43 896774 1559 78846012
Dysstasia 12.39 10.72 404 896413 27342 78820229
Pancreatic neuroendocrine tumour 12.39 10.72 25 896792 650 78846921
CSF immunoglobulin increased 12.34 10.72 7 896810 35 78847536
Hypopituitarism 12.32 10.72 12 896805 3387 78844184
Pulse absent 12.32 10.72 65 896752 10038 78837533
Impaired fasting glucose 12.32 10.72 20 896797 437 78847134
Full blood count abnormal 12.30 10.72 565 896252 39909 78807662
Cardiac tamponade 12.27 10.72 58 896759 9218 78838353
Rib fracture 12.24 10.72 406 896411 27541 78820030
Eosinophil count increased 12.23 10.72 128 896689 16977 78830594
Gastric ulcer haemorrhage 12.21 10.72 56 896761 8971 78838600
Delusion 12.21 10.72 159 896658 20264 78827307
Pulmonary arterial hypertension 12.19 10.72 235 896582 28131 78819440
Hydrops foetalis 12.17 10.72 27 896790 751 78846820
Heart rate irregular 12.16 10.72 466 896351 32213 78815358
Pneumonia fungal 12.12 10.72 75 896742 11135 78836436
Product complaint 12.12 10.72 94 896723 13255 78834316
Forced expiratory volume decreased 12.10 10.72 46 896771 7768 78839803
Hypernatraemia 12.10 10.72 104 896713 14347 78833224
Acute pulmonary oedema 12.09 10.72 102 896715 14128 78833443
Oesophageal carcinoma 12.07 10.72 74 896743 11010 78836561
Neoplasm progression 12.05 10.72 467 896350 51215 78796356
Vascular pseudoaneurysm 12.04 10.72 13 896804 3497 78844074
Type IV hypersensitivity reaction 12.01 10.72 17 896800 4064 78843507
Autonomic nervous system imbalance 12.00 10.72 21 896796 4609 78842962
Prostate cancer stage II 11.98 10.72 5 896812 2221 78845350
Clostridium difficile colitis 11.95 10.72 274 896543 32009 78815562
Dairy intolerance 11.95 10.72 9 896808 78 78847493
Breast abscess 11.94 10.72 40 896777 1426 78846145
Ultrasound antenatal screen 11.93 10.72 25 896792 668 78846903
Post procedural haemorrhage 11.91 10.72 98 896719 13646 78833925
Nail bed disorder 11.91 10.72 15 896802 257 78847314
Necrotising fasciitis 11.90 10.72 32 896785 6018 78841553
Sinus disorder 11.89 10.72 334 896483 22130 78825441
Staphylococcal sepsis 11.87 10.72 107 896710 14619 78832952
Aphasia 11.85 10.72 418 896399 46314 78801257
SARS-CoV-2 antibody test negative 11.84 10.72 14 896803 224 78847347
Blood 25-hydroxycholecalciferol decreased 11.84 10.72 18 896799 371 78847200
Urticaria 11.83 10.72 1865 894952 183336 78664235
Fusarium infection 11.82 10.72 3 896814 1829 78845742
Cleft lip and palate 11.81 10.72 25 896792 673 78846898
Dysphoria 11.80 10.72 22 896795 4712 78842859
Epstein-Barr viraemia 11.79 10.72 5 896812 2200 78845371
Enostosis 11.79 10.72 4 896813 3 78847568
Coordination abnormal 11.79 10.72 131 896686 17181 78830390
Bone metabolism disorder 11.75 10.72 21 896796 497 78847074
Skin ulcer 11.67 10.72 732 896085 53418 78794153
Vital capacity decreased 11.67 10.72 3 896814 1813 78845758
Diverticulitis 11.63 10.72 630 896187 45306 78802265
Genital haemorrhage 11.63 10.72 34 896783 6221 78841350
Salivary hypersecretion 11.62 10.72 103 896714 14121 78833450
Alcohol abuse 11.61 10.72 27 896790 5336 78842235
Paraesthesia 11.60 10.72 2201 894616 174122 78673449
Dissociation 11.59 10.72 17 896800 4004 78843567
Granulocytopenia 11.58 10.72 78 896739 11353 78836218
Complications of transplanted kidney 11.55 10.72 35 896782 6331 78841240
SARS-CoV-2 antibody test positive 11.54 10.72 19 896798 420 78847151
Lip and/or oral cavity cancer 11.51 10.72 33 896784 1080 78846491
Parkinsonism 11.49 10.72 125 896692 16459 78831112
Tumour haemorrhage 11.48 10.72 18 896799 4126 78843445
Chest wall tumour 11.48 10.72 7 896810 41 78847530
Hyperthyroidism 11.47 10.72 178 896639 22031 78825540
Renal cyst 11.46 10.72 231 896586 14501 78833070
Appendicectomy 11.38 10.72 61 896756 2687 78844884
Rectal tenesmus 11.33 10.72 43 896774 1632 78845939
Lip ulceration 11.31 10.72 54 896763 2271 78845300
Urine odour abnormal 11.26 10.72 114 896703 6159 78841412
Haematuria 11.25 10.72 646 896171 68190 78779381
Hyperammonaemic encephalopathy 11.24 10.72 23 896794 4759 78842812
Anger 11.24 10.72 131 896686 17031 78830540
Pancreatic carcinoma 11.23 10.72 98 896719 13479 78834092
Foetal distress syndrome 11.23 10.72 20 896797 472 78847099
Device loosening 11.20 10.72 19 896798 431 78847140
Fear of injection 11.19 10.72 131 896686 7343 78840228
Anaphylactoid reaction 11.19 10.72 28 896789 5394 78842177
Hypercapnia 11.17 10.72 57 896760 8878 78838693
Colitis microscopic 11.15 10.72 73 896744 10695 78836876
Hot flush 11.14 10.72 738 896079 54139 78793432
Hepatic cyst 11.09 10.72 111 896706 5978 78841593
Goitre 11.09 10.72 103 896714 5436 78842135
Areflexia 11.09 10.72 29 896788 5505 78842066
Injection site hypersensitivity 11.08 10.72 47 896770 1878 78845693
Pneumomediastinum 11.07 10.72 15 896802 3652 78843919
Lipase increased 11.06 10.72 125 896692 16341 78831230
Hydrocephalus 11.00 10.72 57 896760 8843 78838728
Acute graft versus host disease in liver 10.99 10.72 4 896813 1931 78845640
Enzyme level decreased 10.98 10.72 5 896812 14 78847557
Radiation pneumonitis 10.98 10.72 17 896800 3916 78843655
Chest pain 10.97 10.72 2915 893902 279389 78568182
Precancerous skin lesion 10.97 10.72 37 896780 1324 78846247
Adjustment disorder with depressed mood 10.95 10.72 153 896664 8933 78838638
Oesophageal discomfort 10.94 10.72 16 896801 318 78847253
Oral mucosal blistering 10.93 10.72 113 896704 6138 78841433
Hypertonia 10.93 10.72 43 896774 7189 78840382
Synovial fluid analysis 10.91 10.72 54 896763 2305 78845266
Cervical spinal stenosis 10.91 10.72 54 896763 2305 78845266
Rectal prolapse 10.90 10.72 51 896766 2127 78845444
Drug dose omission by device 10.89 10.72 35 896782 6215 78841356
Mean cell haemoglobin increased 10.87 10.72 84 896733 4201 78843370
Nystagmus 10.85 10.72 66 896751 9838 78837733
Postpartum haemorrhage 10.83 10.72 41 896776 1554 78846017
Loose tooth 10.82 10.72 66 896751 3051 78844520
Premature labour 10.81 10.72 143 896674 8247 78839324
Hyperparathyroidism primary 10.80 10.72 19 896798 444 78847127
Speech disorder 10.80 10.72 501 896316 53944 78793627
Animal bite 10.78 10.72 59 896758 2620 78844951
Pneumonia cytomegaloviral 10.77 10.72 25 896792 4944 78842627
Abdominal adhesions 10.77 10.72 73 896744 3500 78844071
Loss of employment 10.77 10.72 8 896809 2579 78844992
Femoral hernia incarcerated 10.76 10.72 27 896790 815 78846756
Vaccination site reaction 10.76 10.72 10 896807 119 78847452
Maternal exposure timing unspecified 10.75 10.72 106 896711 5686 78841885
Lacrimal disorder 10.75 10.72 20 896797 489 78847082

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A11CC05 ALIMENTARY TRACT AND METABOLISM
VITAMINS
VITAMIN A AND D, INCL. COMBINATIONS OF THE TWO
Vitamin D and analogues
ATC A11CC55 ALIMENTARY TRACT AND METABOLISM
VITAMINS
VITAMIN A AND D, INCL. COMBINATIONS OF THE TWO
Vitamin D and analogues
ATC M05BB03 MUSCULO-SKELETAL SYSTEM
DRUGS FOR TREATMENT OF BONE DISEASES
DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION
Bisphosphonates, combinations
ATC M05BB04 MUSCULO-SKELETAL SYSTEM
DRUGS FOR TREATMENT OF BONE DISEASES
DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION
Bisphosphonates, combinations
ATC M05BB05 MUSCULO-SKELETAL SYSTEM
DRUGS FOR TREATMENT OF BONE DISEASES
DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION
Bisphosphonates, combinations
ATC M05BB07 MUSCULO-SKELETAL SYSTEM
DRUGS FOR TREATMENT OF BONE DISEASES
DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION
Bisphosphonates, combinations
ATC M05BB08 MUSCULO-SKELETAL SYSTEM
DRUGS FOR TREATMENT OF BONE DISEASES
DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION
Bisphosphonates, combinations
ATC M05BB09 MUSCULO-SKELETAL SYSTEM
DRUGS FOR TREATMENT OF BONE DISEASES
DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION
Bisphosphonates, combinations
ATC M05BX53 MUSCULO-SKELETAL SYSTEM
DRUGS FOR TREATMENT OF BONE DISEASES
DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION
Other drugs affecting bone structure and mineralization
FDA CS M0022797 Vitamin D
MeSH PA D050071 Bone Density Conservation Agents
MeSH PA D000077264 Calcium-Regulating Hormones and Agents
MeSH PA D018977 Micronutrients
MeSH PA D014815 Vitamins
FDA EPC N0000175952 Vitamin D
CHEBI has role CHEBI:77746 Homo sapiens metabolite
CHEBI has role CHEBI:176497 geroprotectors

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Osteomalacia indication 4598005 DOID:10573
Hypocalcemia indication 5291005
Vitamin D deficiency indication 34713006
Hypoparathyroidism indication 36976004 DOID:11199
Rickets indication 41345002 DOID:10609
Osteoporosis indication 64859006 DOID:11476
Vitamin deficiency indication 85670002
Postmenopausal osteoporosis indication 102447009
Prevention of dental caries indication 426482000
Glucocorticoid Induced Osteoporosis indication
Hypogonadal Osteoporosis in Males indication
Vitamin D Dependent Rickets indication
Renal osteodystrophy off-label use 16726004 DOID:13068
Anticonvulsant-induced Osteomalacia off-label use
Gastritis contraindication 4556007 DOID:4029
Poisoning by digitalis glycoside contraindication 12876009
Constipation contraindication 14760008 DOID:2089
Esophagitis contraindication 16761005 DOID:11963
Primary hyperoxaluria contraindication 17901006 DOID:2977
Hyperphosphatemia contraindication 20165001 DOID:0050459
Hypervitaminosis D contraindication 27712000 DOID:9971
Dental fluorosis contraindication 30265004
Ulcer of esophagus contraindication 30811009
Sarcoidosis contraindication 31541009 DOID:11335
Dehydration contraindication 34095006
Hypertensive disorder contraindication 38341003 DOID:10763
Dysphagia contraindication 40739000
Achalasia of esophagus contraindication 45564002 DOID:9164
Atrial fibrillation contraindication 49436004 DOID:0060224
Vitamin E deficiency contraindication 54137008
Hyperlipidemia contraindication 55822004 DOID:1168
Joint pain contraindication 57676002
Acute nephropathy contraindication 58574008
Diarrhea contraindication 62315008
Stricture of esophagus contraindication 63305008
Hypervitaminosis A contraindication 64559002 DOID:9972
Blood coagulation disorder contraindication 64779008 DOID:1247
Hypercalcemia contraindication 66931009 DOID:12678
Hyperparathyroidism contraindication 66999008 DOID:13543
Fracture of femur contraindication 71620000
Hypercalciuria contraindication 71938000
Duodenitis contraindication 72007001 DOID:8643
Diabetes mellitus contraindication 73211009 DOID:9351
Kidney disease contraindication 90708001 DOID:557
Kidney stone contraindication 95570007
Anemia due to enzyme deficiency contraindication 111577008
Neoplasm of endometrium contraindication 123844007 DOID:1380
Neoplasm of prostate contraindication 126906006 DOID:10283
Hb SS disease contraindication 127040003 DOID:10923
Bed-ridden contraindication 160685001
Acute peptic ulcer contraindication 196682000
Osteolysis contraindication 203522001
Disease of liver contraindication 235856003 DOID:409
Esophageal dysmotility contraindication 266434009 DOID:9192
Arteriosclerosis obliterans contraindication 361133006 DOID:5160
Malignant tumor of cervix contraindication 363354003 DOID:4362
Hemochromatosis contraindication 399187006 DOID:2352
Central nervous system depression contraindication 418072004
Aseptic necrosis of bone of jaw contraindication 441809006
Carcinoma of female breast contraindication 447782002
Vitamin K Deficiency Induced Hypoprothrombinemia contraindication
Malabsorption States contraindication
High Grade Dysplasia associated with Barrett's Esophagus contraindication
Esophageal Obstruction contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Vitamin D3 receptor Nuclear hormone receptor AGONIST EC50 9.68 CHEMBL CHEMBL
Glycine receptor subunit alpha-1 Ion channel EC50 6.40 CHEMBL
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial Enzyme WOMBAT-PK
Vitamin D 25-hydroxylase Enzyme WOMBAT-PK
Sterol 26-hydroxylase, mitochondrial Enzyme WOMBAT-PK
Vitamin D3 receptor Nuclear hormone receptor EC50 6.05 CHEMBL

External reference:

IDSource
D00188 KEGG_DRUG
4017667 VANDF
C0008318 UMLSCUI
CHEBI:28940 CHEBI
VD3 PDB_CHEM_ID
CHEMBL1042 ChEMBL_ID
DB00169 DRUGBANK_ID
2747 IUPHAR_LIGAND_ID
5280795 PUBCHEM_CID
1244014 RXNORM
15676 MMSL
199274 MMSL
4434 MMSL
4868 MMSL
4871 MMSL
d03129 MMSL
001014 NDDF
108943009 SNOMEDCT_US
18414002 SNOMEDCT_US
D002762 MESH_DESCRIPTOR_UI
1497 INN_ID
1C6V77QF41 UNII

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
FOSAMAX PLUS D HUMAN PRESCRIPTION DRUG LABEL 2 0006-0270 TABLET 5600 [iU] ORAL NDA 27 sections
FOSAMAX PLUS D HUMAN PRESCRIPTION DRUG LABEL 2 0006-0710 TABLET 2800 [iU] ORAL NDA 27 sections
NataFort HUMAN PRESCRIPTION DRUG LABEL 10 0178-0716 TABLET 400 [iU] ORAL Unapproved drug other 12 sections
CitraNatal Harmony 3.0 HUMAN PRESCRIPTION DRUG LABEL 8 0178-0796 CAPSULE, GELATIN COATED 400 [iU] ORAL unapproved drug other 10 sections
CitraNatal Harmony 3.0 HUMAN PRESCRIPTION DRUG LABEL 8 0178-0796 CAPSULE, GELATIN COATED 400 [iU] ORAL unapproved drug other 10 sections
CitraNatal Harmony HUMAN PRESCRIPTION DRUG LABEL 8 0178-0798 CAPSULE, GELATIN COATED 400 [iU] ORAL UNAPPROVED DRUG OTHER 11 sections
CitraNatal Harmony HUMAN PRESCRIPTION DRUG LABEL 8 0178-0799 CAPSULE, GELATIN COATED 400 [iU] ORAL Unapproved drug other 11 sections
CitraNatal Harmony HUMAN PRESCRIPTION DRUG LABEL 8 0178-0812 CAPSULE, GELATIN COATED 400 [iU] ORAL Unapproved drug other 11 sections
CitraNatal Medley HUMAN PRESCRIPTION DRUG LABEL 8 0178-0896 CAPSULE, GELATIN COATED 200 [iU] ORAL unapproved drug other 10 sections
CitraNatal Medley HUMAN PRESCRIPTION DRUG LABEL 8 0178-0896 CAPSULE, GELATIN COATED 200 [iU] ORAL unapproved drug other 10 sections
Select OB HUMAN PRESCRIPTION DRUG LABEL 15 0642-0077 TABLET, CHEWABLE 400 [iU] ORAL UNAPPROVED DRUG OTHER 14 sections
Vitafol Ultra HUMAN PRESCRIPTION DRUG LABEL 17 0642-0093 CAPSULE, LIQUID FILLED 25 ug ORAL UNAPPROVED DRUG OTHER 13 sections
Vitafol Ultra HUMAN PRESCRIPTION DRUG LABEL 17 0642-0093 CAPSULE, LIQUID FILLED 25 ug ORAL UNAPPROVED DRUG OTHER 13 sections
Vitafol Nano HUMAN PRESCRIPTION DRUG LABEL 7 0642-0094 TABLET, COATED 25 ug ORAL UNAPPROVED DRUG OTHER 14 sections
Vitafol Nano HUMAN PRESCRIPTION DRUG LABEL 7 0642-0094 TABLET, COATED 25 ug ORAL UNAPPROVED DRUG OTHER 14 sections
Select OB HUMAN PRESCRIPTION DRUG LABEL 15 0642-0120 TABLET, CHEWABLE 400 [iU] ORAL UNAPPROVED DRUG OTHER 13 sections
Strovite One Caplets HUMAN PRESCRIPTION DRUG LABEL 20 0642-0207 TABLET 25 ug ORAL UNAPPROVED DRUG OTHER 14 sections
Strovite One Caplets HUMAN PRESCRIPTION DRUG LABEL 20 0642-0207 TABLET 25 ug ORAL UNAPPROVED DRUG OTHER 14 sections
Vitafol HUMAN PRESCRIPTION DRUG LABEL 4 0642-7468 STRIP 1000 [iU] ORAL Unapproved drug other 13 sections
Vitafol Fe Plus HUMAN PRESCRIPTION DRUG LABEL 17 0642-7473 CAPSULE, LIQUID FILLED 25 mg ORAL UNAPPROVED DRUG OTHER 14 sections
Vitafol Fe Plus HUMAN PRESCRIPTION DRUG LABEL 17 0642-7473 CAPSULE, LIQUID FILLED 25 mg ORAL UNAPPROVED DRUG OTHER 14 sections
Marnatal F HUMAN PRESCRIPTION DRUG LABEL 13 0682-1570 CAPSULE 400 [iU] ORAL UNAPPROVED DRUG OTHER 4 sections
O-Cal Prenatal Vitamin HUMAN PRESCRIPTION DRUG LABEL 16 0813-0202 TABLET 400 [iU] ORAL UNAPPROVED DRUG OTHER 6 sections
Dialyvite Supreme D HUMAN PRESCRIPTION DRUG LABEL 13 10542-009 TABLET, COATED 2000 [iU] ORAL Unapproved drug other 7 sections
Dialyvite Supreme D HUMAN PRESCRIPTION DRUG LABEL 13 10542-009 TABLET, COATED 2000 [iU] ORAL Unapproved drug other 7 sections
PRENATAL PLUS HUMAN PRESCRIPTION DRUG LABEL 15 10544-549 TABLET, FILM COATED 400 [iU] ORAL unapproved drug other 8 sections
PRENATAL PLUS IRON HUMAN PRESCRIPTION DRUG LABEL 15 10544-609 TABLET, FILM COATED 400 [iU] ORAL UNAPPROVED DRUG OTHER 7 sections
Se-Natal 19 HUMAN PRESCRIPTION DRUG LABEL 15 13925-116 TABLET 400 [iU] ORAL unapproved drug other 15 sections
Se-Natal 19 HUMAN PRESCRIPTION DRUG LABEL 15 13925-116 TABLET 400 [iU] ORAL unapproved drug other 15 sections
Se-Natal 19 Chewable HUMAN PRESCRIPTION DRUG LABEL 14 13925-117 TABLET, CHEWABLE 400 [iU] ORAL unapproved drug other 16 sections