colecalciferol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
Vitamin D analogues/derivatives 2840 67-97-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • Vitamin D3
  • cholecalciferol
  • arachitol
  • calciol
  • calcirol
  • colecalciferol
Derivative of 7-dehydroxycholesterol formed by ULTRAVIOLET RAYS breaking of the C9-C10 bond. It differs from ERGOCALCIFEROL in having a single bond between C22 and C23 and lacking a methyl group at C24. Some experts recommend maintaining recommended levels of vitamin D intake during the COVID-19 pandemic to maintain bone and muscle health and avoid deficiency. Efficacy of vitamin D supplementation in the prevention or treatment of COVID-19 has not been established.
  • Molecular weight: 384.65
  • Formula: C27H44O
  • CLOGP: 9.48
  • LIPINSKI: 1
  • HAC: 1
  • HDO: 1
  • TPSA: 20.23
  • ALOGS: -6.01
  • ROTB: 6
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
20 mcg O
10 mg O
5 mg O
10 mg O

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.10 mg/mL Benet LZ, Broccatelli F, Oprea TI

Approvals:

DateAgencyCompanyOrphan
May 18, 2000 FDA SANDOZ

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 1256.74 10.65 117 645960 131772 49827275
Toxicity to various agents 1084.22 10.65 688 645389 211811 49747236
Pemphigus 606.11 10.65 3085 642992 117081 49841966
Systemic lupus erythematosus 556.40 10.65 3381 642696 137241 49821806
Death 522.39 10.65 2258 643819 323121 49635926
Drug abuse 503.89 10.65 80 645997 59766 49899281
Glossodynia 481.61 10.65 2817 643260 112752 49846295
Intentional overdose 452.89 10.65 119 645958 62385 49896662
Alopecia 428.57 10.65 4898 641179 240149 49718898
Rheumatoid arthritis 419.10 10.65 4188 641889 198362 49760685
Drug interaction 409.39 10.65 1250 644827 198371 49760676
Abdominal discomfort 393.33 10.65 4604 641473 227037 49732010
Overdose 366.24 10.65 440 645637 99287 49859760
Arthropathy 360.04 10.65 3333 642744 154573 49804474
Hand deformity 341.18 10.65 2320 643757 97879 49861168
Drug hypersensitivity 338.55 10.65 1852 644225 249158 49709889
Wound 316.36 10.65 2374 643703 103420 49855627
Maternal exposure during pregnancy 301.94 10.65 3244 642833 156534 49802513
Suicide attempt 288.32 10.65 150 645927 51582 49907465
Cardiac arrest 287.48 10.65 388 645689 83263 49875784
Femur fracture 282.30 10.65 1085 644992 36379 49922668
Pain 261.01 10.65 9427 636650 569476 49389571
Depressed level of consciousness 259.32 10.65 172 645905 51781 49907266
Febrile neutropenia 220.28 10.65 584 645493 97083 49861964
Joint swelling 203.47 10.65 4323 641754 240963 49718084
Fatigue 202.95 10.65 11000 635077 696601 49262446
Cardio-respiratory arrest 202.91 10.65 233 645844 53659 49905388
Arthralgia 201.41 10.65 7161 638916 431541 49527506
Pericarditis 191.90 10.65 1686 644391 77003 49882044
Anti-cyclic citrullinated peptide antibody positive 186.67 10.65 1540 644537 69047 49890000
Discomfort 177.72 10.65 2141 643936 106239 49852808
Malignant neoplasm progression 173.63 10.65 382 645695 67742 49891305
Infusion related reaction 172.20 10.65 3082 642995 166475 49792572
Respiratory arrest 170.21 10.65 85 645992 29924 49929123
Acute kidney injury 169.56 10.65 1978 644099 226080 49732967
Hypotension 169.05 10.65 2058 644019 233411 49725636
Coma 165.58 10.65 295 645782 56584 49902463
Device expulsion 155.57 10.65 87 645990 28735 49930312
Osteoarthritis 152.54 10.65 1441 644636 67165 49891882
Sedation 149.19 10.65 104 645973 30506 49928541
Psoriasis 148.82 10.65 1440 644637 67560 49891487
Synovitis 148.69 10.65 2314 643763 121551 49837496
Swelling 144.42 10.65 3470 642607 197402 49761645
Low turnover osteopathy 143.96 10.65 214 645863 3780 49955267
Hepatic function abnormal 138.06 10.65 128 645949 32553 49926494
Agitation 135.49 10.65 300 645777 53084 49905963
Product use issue 131.47 10.65 2658 643419 146817 49812230
Cardiac failure 130.11 10.65 514 645563 75526 49883521
Renal failure 126.93 10.65 818 645259 105815 49853232
Contraindicated product administered 126.79 10.65 2636 643441 146322 49812725
Drug reaction with eosinophilia and systemic symptoms 121.64 10.65 110 645967 28314 49930733
Lactic acidosis 120.44 10.65 149 645928 33206 49925841
Nasopharyngitis 117.96 10.65 3262 642815 189665 49769382
Multiple organ dysfunction syndrome 117.27 10.65 296 645781 50041 49909006
Metabolic acidosis 114.23 10.65 200 645877 38625 49920422
Serotonin syndrome 112.66 10.65 90 645987 24623 49934424
Drug resistance 111.96 10.65 51 646026 18938 49940109
Neutropenia 111.93 10.65 1278 644799 146687 49812360
Knee arthroplasty 110.77 10.65 811 645266 35035 49924012
Intentional self-injury 108.11 10.65 82 645995 23030 49936017
Psoriatic arthropathy 108.10 10.65 995 645082 46037 49913010
Bradycardia 108.00 10.65 439 645638 63987 49895060
Hip arthroplasty 107.30 10.65 711 645366 29718 49929329
Intramedullary rod insertion 107.12 10.65 130 645947 1870 49957177
Rheumatoid factor positive 104.78 10.65 1035 645042 48824 49910223
Anaphylactic reaction 99.89 10.65 354 645723 53701 49905346
Duodenal ulcer perforation 99.86 10.65 955 645122 44656 49914391
Somnolence 99.53 10.65 1386 644691 153599 49805448
Disease progression 97.71 10.65 769 645308 95097 49863950
Hepatic failure 97.07 10.65 164 645913 32119 49926928
Helicobacter infection 96.91 10.65 1016 645061 48686 49910361
Vitamin D deficiency 96.58 10.65 343 645734 11059 49947988
Musculoskeletal stiffness 96.37 10.65 2233 643844 126248 49832799
Rhabdomyolysis 94.44 10.65 225 645852 38802 49920245
Mydriasis 89.89 10.65 14 646063 10613 49948434
Sinusitis 89.57 10.65 2830 643247 167728 49791319
Myocardial infarction 88.94 10.65 718 645359 88309 49870738
Dyspnoea 88.54 10.65 5914 640163 541694 49417353
Electrocardiogram QT prolonged 84.20 10.65 358 645719 51528 49907519
Cytomegalovirus infection 83.66 10.65 64 646013 17898 49941149
Poisoning 82.12 10.65 28 646049 12401 49946646
Drug dependence 81.57 10.65 79 645998 19680 49939367
Cardiac failure congestive 81.35 10.65 687 645390 83695 49875352
Tachycardia 81.27 10.65 847 645230 98916 49860131
Respiratory failure 80.61 10.65 759 645318 90422 49868625
Thrombocytopenia 80.45 10.65 1146 644931 126527 49832520
Impaired healing 79.25 10.65 1292 644785 68494 49890553
Shock 78.01 10.65 89 645988 20561 49938486
Tooth disorder 77.07 10.65 552 645525 23676 49935371
Altered state of consciousness 74.85 10.65 102 645975 21808 49937239
Peripheral swelling 73.62 10.65 3274 642803 202662 49756385
Product quality issue 73.01 10.65 180 645897 30678 49928369
Emotional distress 72.78 10.65 161 645916 28502 49930545
Seizure 72.52 10.65 1063 645014 116811 49842236
Vomiting 72.37 10.65 4988 641089 455770 49503277
Red blood cell sedimentation rate abnormal 72.29 10.65 405 645672 15938 49943109
Osteoporosis 71.50 10.65 882 645195 43997 49915050
Respiratory depression 71.20 10.65 32 646045 11978 49947069
Foot fracture 70.56 10.65 469 645608 19622 49939425
Drug withdrawal syndrome 69.50 10.65 134 645943 24947 49934100
Sickle cell anaemia with crisis 67.62 10.65 167 645910 4376 49954671
Pain in extremity 67.41 10.65 4189 641888 268676 49690371
Spinal osteoarthritis 66.21 10.65 355 645722 13737 49945310
Open reduction of fracture 65.54 10.65 76 646001 1039 49958008
Mental status changes 64.72 10.65 241 645836 36031 49923016
Off label use 64.69 10.65 6959 639118 467467 49491580
Hepatic enzyme increased 64.53 10.65 2250 643827 135130 49823917
Hypoglycaemia 63.74 10.65 411 645666 53170 49905877
Encephalopathy 63.46 10.65 219 645858 33492 49925555
Palmar-plantar erythrodysaesthesia syndrome 62.38 10.65 100 645977 19998 49939049
Fall 62.33 10.65 5024 641053 329908 49629139
Acute hepatic failure 62.06 10.65 65 646012 15612 49943435
Hyperkalaemia 61.30 10.65 361 645716 47728 49911319
Neuroleptic malignant syndrome 60.93 10.65 33 646044 11097 49947950
Torsade de pointes 60.66 10.65 38 646039 11797 49947250
International normalised ratio increased 60.44 10.65 314 645763 42838 49916209
Infective pulmonary exacerbation of cystic fibrosis 60.33 10.65 230 645847 7679 49951368
Fracture nonunion 60.10 10.65 104 645973 2100 49956947
Extrapyramidal disorder 60.03 10.65 38 646039 11732 49947315
No adverse event 59.33 10.65 224 645853 33354 49925693
Sedation complication 59.23 10.65 19 646058 8747 49950300
Hepatotoxicity 58.94 10.65 166 645911 27060 49931987
Loss of consciousness 58.44 10.65 958 645119 103395 49855652
Unresponsive to stimuli 58.20 10.65 198 645879 30411 49928636
Fracture delayed union 57.67 10.65 104 645973 2172 49956875
Blood creatine phosphokinase increased 57.64 10.65 160 645917 26207 49932840
Hyponatraemia 56.71 10.65 874 645203 95265 49863782
Ejection fraction decreased 56.68 10.65 93 645984 18427 49940620
Product use in unapproved indication 56.37 10.65 1090 644987 114729 49844318
Basal cell carcinoma 56.15 10.65 499 645578 22857 49936190
Aspartate aminotransferase increased 56.11 10.65 681 645396 77317 49881730
Creatinine renal clearance decreased 55.76 10.65 42 646035 11839 49947208
Arthritis 55.38 10.65 1475 644602 85246 49873801
Ventricular fibrillation 55.37 10.65 33 646044 10526 49948521
Sopor 54.40 10.65 107 645970 19772 49939275
Spinal fracture 54.37 10.65 363 645714 15210 49943837
Brain oedema 52.77 10.65 48 646029 12322 49946725
Alanine aminotransferase increased 52.55 10.65 802 645275 87557 49871490
Posterior reversible encephalopathy syndrome 52.52 10.65 68 646009 14860 49944187
Stress fracture 52.50 10.65 200 645877 6675 49952372
Disseminated intravascular coagulation 52.48 10.65 86 645991 17049 49941998
Injection site reaction 51.95 10.65 913 645164 49119 49909928
Anaphylactic shock 51.34 10.65 113 645964 20042 49939005
Intentional product misuse 50.86 10.65 368 645709 46366 49912681
Ventricular tachycardia 50.74 10.65 77 646000 15744 49943303
Accidental exposure to product 50.34 10.65 140 645937 22917 49936130
Body height decreased 50.02 10.65 236 645841 8672 49950375
Syncope 49.93 10.65 970 645107 102032 49857015
Hypoxia 49.36 10.65 416 645661 50707 49908340
Unintentional medical device removal 48.70 10.65 6 646071 5429 49953618
Renal impairment 48.39 10.65 677 645400 74984 49884063
Ascites 47.97 10.65 265 645812 35596 49923451
Septic shock 47.95 10.65 482 645595 56693 49902354
Psychotic disorder 47.95 10.65 132 645945 21680 49937367
Pyrexia 47.85 10.65 4191 641886 376012 49583035
Intervertebral disc degeneration 47.74 10.65 315 645762 13146 49945901
Anaemia 47.69 10.65 2686 643391 249770 49709277
Joint effusion 47.57 10.65 307 645770 12714 49946333
Akathisia 47.13 10.65 23 646054 8206 49950841
Coagulopathy 47.04 10.65 99 645978 17845 49941202
Injection site pruritus 46.93 10.65 751 645326 39660 49919387
Blood alkaline phosphatase increased 46.09 10.65 285 645792 37241 49921806
Foot deformity 45.96 10.65 410 645667 18800 49940247
Anaemia postoperative 45.48 10.65 90 645987 2021 49957026
Cardiogenic shock 45.29 10.65 81 645996 15518 49943529
Blood cholesterol increased 45.25 10.65 972 645105 54243 49904804
Thoracic vertebral fracture 44.85 10.65 134 645943 3939 49955108
Myelosuppression 44.11 10.65 65 646012 13452 49945595
Bone marrow failure 43.95 10.65 192 645885 27432 49931615
Orthostatic hypotension 43.87 10.65 210 645867 29271 49929776
Pulmonary embolism 43.63 10.65 977 645100 100727 49858320
Blood bilirubin increased 43.26 10.65 236 645841 31802 49927245
Tooth fracture 43.24 10.65 240 645837 9411 49949636
Anhedonia 43.01 10.65 35 646042 9489 49949558
Night sweats 42.84 10.65 634 645443 32940 49926107
Venoocclusive liver disease 42.71 10.65 3 646074 4258 49954789
Nausea 42.70 10.65 8149 637928 697249 49261798
Product complaint 42.68 10.65 50 646027 11416 49947631
Tremor 42.67 10.65 1128 644949 113775 49845272
Bone density decreased 42.25 10.65 264 645813 10811 49948236
Exposure during pregnancy 41.89 10.65 1918 644159 119097 49839950
Acute respiratory distress syndrome 41.82 10.65 134 645943 20965 49938082
Gastrointestinal haemorrhage 41.74 10.65 671 645406 72650 49886397
Hypokalaemia 41.63 10.65 832 645245 87160 49871887
Delirium 41.43 10.65 301 645776 37891 49921156
Device difficult to use 41.42 10.65 39 646038 9847 49949200
Transplant rejection 41.33 10.65 37 646040 9572 49949475
Sepsis 41.33 10.65 1337 644740 131588 49827459
Rheumatic fever 40.87 10.65 361 645716 16506 49942541
Muscle spasticity 40.72 10.65 366 645711 16818 49942229
Neurotoxicity 40.63 10.65 79 645998 14661 49944386
Stevens-Johnson syndrome 40.48 10.65 142 645935 21610 49937437
Metastases to liver 40.32 10.65 127 645950 19977 49939070
Accidental overdose 40.17 10.65 122 645955 19411 49939636
Device use error 40.14 10.65 9 646068 5257 49953790
Hyperhidrosis 40.10 10.65 853 645224 88573 49870474
Swollen joint count increased 40.10 10.65 326 645751 14547 49944500
Osteopenia 40.09 10.65 362 645715 16656 49942391
Thrombotic microangiopathy 40.08 10.65 32 646045 8759 49950288
Pulmonary oedema 40.03 10.65 415 645662 48523 49910524
Restlessness 40.03 10.65 175 645902 24998 49934049
Aggression 39.87 10.65 137 645940 20979 49938068
Lower respiratory tract infection 39.53 10.65 1538 644539 93663 49865384
Suicidal ideation 39.28 10.65 485 645592 54900 49904147
Dystonia 39.26 10.65 57 646020 11869 49947178
Juvenile idiopathic arthritis 38.87 10.65 102 645975 2777 49956270
Toxic skin eruption 38.81 10.65 52 646025 11199 49947848
Confusional state 38.68 10.65 1959 644118 183969 49775078
Hepatocellular injury 38.51 10.65 185 645892 25762 49933285
Product dose omission issue 38.51 10.65 2784 643293 181054 49777993
Urinary tract infection 38.37 10.65 3340 642737 220680 49738367
Hypomania 37.96 10.65 6 646071 4499 49954548
Graft versus host disease 37.23 10.65 16 646061 6150 49952897
Pleural effusion 37.10 10.65 775 645302 80679 49878368
Metastases to central nervous system 37.07 10.65 54 646023 11228 49947819
Haematotoxicity 36.94 10.65 28 646049 7867 49951180
Drug ineffective for unapproved indication 36.93 10.65 143 645934 21138 49937909
Injection site erythema 36.84 10.65 1234 644843 73702 49885345
Bone giant cell tumour 36.77 10.65 14 646063 16 49959031
Fracture 36.61 10.65 352 645725 16481 49942566
Acute graft versus host disease 36.39 10.65 4 646073 3954 49955093
Injection site swelling 36.38 10.65 742 645335 41031 49918016
Myoclonus 36.15 10.65 82 645995 14388 49944659
Scoliosis 36.04 10.65 173 645904 6403 49952644
Status epilepticus 35.96 10.65 73 646004 13333 49945714
Multiple sclerosis relapse 35.74 10.65 758 645319 42206 49916841
Cerebral infarction 35.70 10.65 148 645929 21456 49937591
Disorientation 35.50 10.65 286 645791 35198 49923849
Bone loss 35.40 10.65 94 645983 2578 49956469
Wrong technique in product usage process 35.38 10.65 497 645580 55013 49904034
Metastases to bone 35.17 10.65 115 645962 17880 49941167
Cholecystitis chronic 35.10 10.65 43 646034 9626 49949421
Obstructive airways disorder 34.95 10.65 94 645983 15558 49943489
Cognitive disorder 34.94 10.65 377 645700 43746 49915301
Blood pressure decreased 34.78 10.65 503 645574 55406 49903641
Toxic epidermal necrolysis 34.57 10.65 144 645933 20848 49938199
Hyperglycaemia 34.35 10.65 298 645779 36107 49922940
Blood glucose increased 34.16 10.65 673 645404 70651 49888396
Multiple fractures 34.15 10.65 171 645906 6440 49952607
Miosis 34.12 10.65 19 646058 6291 49952756
Bronchospasm 34.08 10.65 88 645989 14766 49944281
Synovial cyst 33.91 10.65 199 645878 7967 49951080
Neutrophil count decreased 33.80 10.65 400 645677 45626 49913421
Substance abuse 33.62 10.65 6 646071 4118 49954929
Dysarthria 33.61 10.65 310 645767 37093 49921954
Angioedema 33.54 10.65 313 645764 37363 49921684
Lower respiratory tract infection viral 33.54 10.65 42 646035 625 49958422
Device dislocation 33.52 10.65 151 645926 21395 49937652
Face oedema 33.50 10.65 116 645961 17723 49941324
Pancreatitis 33.39 10.65 365 645712 42249 49916798
Acute myeloid leukaemia 33.30 10.65 91 645986 14983 49944064
Acute generalised exanthematous pustulosis 33.25 10.65 39 646038 8899 49950148
Carpal tunnel syndrome 33.23 10.65 346 645731 16547 49942500
Ear pain 32.98 10.65 526 645551 27757 49931290
Cerebral haemorrhage 32.94 10.65 206 645871 26846 49932201
Abnormal behaviour 32.90 10.65 134 645943 19524 49939523
Haemodialysis 32.73 10.65 35 646042 8327 49950720
Cerebrovascular accident 32.19 10.65 941 645136 93739 49865308
Atypical femur fracture 31.94 10.65 136 645941 4780 49954267
Respiratory distress 31.78 10.65 243 645834 30246 49928801
Asphyxia 31.34 10.65 15 646062 5412 49953635
Platelet count decreased 31.33 10.65 1013 645064 99713 49859334
Disability assessment scale score increased 31.28 10.65 83 645994 2275 49956772
Cyanosis 31.11 10.65 95 645982 15089 49943958
Gamma-glutamyltransferase increased 30.92 10.65 236 645841 29387 49929660
Back pain 30.91 10.65 3235 642842 216795 49742252
Hallucination, auditory 30.89 10.65 56 646021 10672 49948375
Wrist fracture 30.54 10.65 251 645826 11236 49947811
Dysmorphism 30.52 10.65 78 645999 2089 49956958
C-reactive protein abnormal 30.50 10.65 512 645565 27297 49931750
Metastases to lung 30.42 10.65 59 646018 10961 49948086
Live birth 30.38 10.65 332 645745 16076 49942971
Deep vein thrombosis 30.36 10.65 708 645369 72596 49886451
Tonsillar ulcer 30.27 10.65 27 646050 264 49958783
Oropharyngeal pain 30.23 10.65 1248 644829 76553 49882494
Abortion spontaneous 30.05 10.65 722 645355 41050 49917997
Contusion 30.03 10.65 1735 644342 110448 49848599
Vitamin D decreased 29.98 10.65 197 645880 8209 49950838
Disease recurrence 29.90 10.65 143 645934 19938 49939109
Neck deformity 29.75 10.65 73 646004 1905 49957142
Leukopenia 29.73 10.65 646 645431 66882 49892165
Bone disorder 29.63 10.65 368 645709 18384 49940663
Cholestasis 29.61 10.65 196 645881 25205 49933842
Renal injury 29.50 10.65 40 646037 8571 49950476
Influenza 29.45 10.65 1412 644665 88126 49870921
Inappropriate antidiuretic hormone secretion 29.29 10.65 79 645998 13064 49945983
Hypothermia 29.28 10.65 69 646008 11947 49947100
Dental caries 29.20 10.65 221 645856 9646 49949401
Malignant melanoma 29.14 10.65 225 645852 9883 49949164
Rebound effect 28.80 10.65 98 645979 3091 49955956
Musculoskeletal pain 28.55 10.65 1160 644917 71017 49888030
Lumbar vertebral fracture 28.20 10.65 125 645952 4472 49954575
Interstitial lung disease 28.18 10.65 493 645584 52683 49906364
Injury 28.09 10.65 447 645630 48478 49910569
Cardiotoxicity 27.97 10.65 29 646048 6998 49952049
Anuria 27.86 10.65 64 646013 11180 49947867
Jaundice 27.85 10.65 210 645867 26219 49932828
Haemorrhage 27.83 10.65 497 645580 52944 49906103
Coronary artery disease 27.75 10.65 244 645833 29482 49929565
Recalled product 27.66 10.65 56 646021 1279 49957768
Pregnancy 27.65 10.65 531 645546 29046 49930001
Genital haemorrhage 27.46 10.65 26 646051 6548 49952499
Medical device removal 27.44 10.65 51 646026 1091 49957956
Sinus tachycardia 27.37 10.65 160 645917 21194 49937853
Uterine perforation 27.24 10.65 25 646052 6390 49952657
Erythema multiforme 27.18 10.65 46 646031 9004 49950043
Bone density abnormal 27.00 10.65 93 645984 2952 49956095
Pathogen resistance 26.84 10.65 20 646057 5669 49953378
Dental implantation 26.81 10.65 36 646041 576 49958471
Drug ineffective 26.69 10.65 9728 636349 809605 49149442
Joint laxity 26.51 10.65 79 645998 2319 49956728
Asthma 26.47 10.65 904 645173 88433 49870614
Mania 26.35 10.65 63 646014 10853 49948194
Removal of internal fixation 26.33 10.65 15 646062 65 49958982
Bronchopulmonary aspergillosis 26.28 10.65 35 646042 7557 49951490
Rash maculo-papular 26.07 10.65 216 645861 26425 49932622
Bronchitis 26.00 10.65 1601 644476 102558 49856489
Drug abuser 25.64 10.65 3 646074 2825 49956222
Oedema 25.51 10.65 691 645386 69490 49889557
Exostosis 25.50 10.65 244 645833 11409 49947638
Gestational diabetes 25.45 10.65 173 645904 7292 49951755
Skin cancer 25.37 10.65 206 645871 9188 49949859
Blood creatinine increased 25.37 10.65 759 645318 75401 49883646
Blood pressure fluctuation 25.11 10.65 617 645460 35206 49923841
Graft versus host disease in gastrointestinal tract 25.09 10.65 3 646074 2778 49956269
Tardive dyskinesia 24.75 10.65 34 646043 7245 49951802
Weight increased 24.73 10.65 2942 643135 198949 49760098
Schizoaffective disorder 24.69 10.65 73 646004 2133 49956914
Abortion incomplete 24.53 10.65 5 646072 3121 49955926
Fear 24.46 10.65 99 645978 14450 49944597
Therapeutic product effect decreased 24.45 10.65 2036 644041 134014 49825033
Myopathy 24.31 10.65 50 646027 9089 49949958
Pulseless electrical activity 24.23 10.65 31 646046 6810 49952237
Multiple sclerosis 24.22 10.65 382 645695 20111 49938936
Lethargy 24.10 10.65 465 645612 48967 49910080
Febrile bone marrow aplasia 24.06 10.65 27 646050 6284 49952763
Muscle strain 24.01 10.65 164 645913 6924 49952123
Pregnancy with contraceptive device 23.98 10.65 11 646066 4068 49954979
Temperature regulation disorder 23.93 10.65 12 646065 4215 49954832
BK virus infection 23.91 10.65 4 646073 2877 49956170
Cardiomyopathy 23.79 10.65 110 645967 15476 49943571
Stress cardiomyopathy 23.77 10.65 40 646037 7847 49951200
Dehydration 23.70 10.65 1651 644426 150798 49808249
Drug screen positive 23.66 10.65 7 646070 3395 49955652
Agranulocytosis 23.63 10.65 168 645909 21253 49937794
Gastrooesophageal reflux disease 23.62 10.65 1198 644879 75230 49883817
Developmental hip dysplasia 23.09 10.65 51 646026 1240 49957807
Diabetes mellitus inadequate control 23.02 10.65 88 645989 13057 49945990
Respiratory acidosis 22.75 10.65 26 646051 6002 49953045
Multiple-drug resistance 22.72 10.65 7 646070 3307 49955740
Transplant dysfunction 22.71 10.65 16 646061 4668 49954379
Polyarthritis 22.60 10.65 176 645901 7751 49951296
Haemophagocytic lymphohistiocytosis 22.32 10.65 48 646029 8585 49950462
Dry eye 22.26 10.65 552 645525 31543 49927504
Cataract 22.26 10.65 775 645302 46525 49912522
Colitis ulcerative 22.18 10.65 320 645757 16534 49942513
Talipes 22.14 10.65 53 646024 1361 49957686
Anxiety 22.08 10.65 1959 644118 175647 49783400
Left ventricular dysfunction 22.05 10.65 65 646012 10441 49948606
Bradypnoea 21.98 10.65 6 646071 3068 49955979
Lumbar spinal stenosis 21.85 10.65 108 645969 4046 49955001
Laryngitis 21.83 10.65 225 645852 10731 49948316
Caesarean section 21.82 10.65 300 645777 15339 49943708
Toxic encephalopathy 21.68 10.65 23 646054 5492 49953555
Chronic graft versus host disease 21.65 10.65 5 646072 2862 49956185
Cytomegalovirus viraemia 21.65 10.65 17 646060 4692 49954355
Bone metabolism disorder 21.62 10.65 23 646054 284 49958763
Localised infection 21.31 10.65 450 645627 25035 49934012
Exposure to toxic agent 21.29 10.65 10 646067 3648 49955399
Aspergillus infection 21.11 10.65 34 646043 6787 49952260
Hypercalciuria 21.01 10.65 20 646057 214 49958833
Speech disorder 21.00 10.65 323 645754 35225 49923822
Mucosal inflammation 21.00 10.65 373 645704 39769 49919278
Hepatic cytolysis 20.99 10.65 45 646032 8058 49950989
Cystic fibrosis 20.79 10.65 82 645995 2782 49956265
Dermatitis exfoliative 20.71 10.65 21 646056 5121 49953926
Ketoacidosis 20.67 10.65 12 646065 3883 49955164
Joint injury 20.64 10.65 392 645685 21397 49937650
Tibia fracture 20.53 10.65 112 645965 4363 49954684
Melaena 20.29 10.65 232 645845 26632 49932415
Periprosthetic fracture 20.21 10.65 26 646051 398 49958649
Skin papilloma 20.18 10.65 107 645970 4122 49954925
Intraductal proliferative breast lesion 20.15 10.65 75 646002 2475 49956572
Pulmonary hypertension 19.96 10.65 303 645774 33114 49925933
Drug-induced liver injury 19.93 10.65 246 645831 27849 49931198
Hyperlipidaemia 19.91 10.65 324 645753 17166 49941881
Hyperprolactinaemia 19.89 10.65 9 646068 3356 49955691
Angina pectoris 19.84 10.65 226 645851 25962 49933085
Muscle rigidity 19.78 10.65 62 646015 9767 49949280
Spondylolisthesis 19.77 10.65 86 645991 3051 49955996
Hallucination 19.77 10.65 449 645628 46208 49912839
Fluid retention 19.65 10.65 494 645583 50155 49908892
Tendonitis 19.60 10.65 311 645766 16394 49942653
Gastroenteritis viral 19.56 10.65 343 645734 18443 49940604
Rash 19.48 10.65 6056 640021 431415 49527632
Endodontic procedure 19.44 10.65 78 645999 2668 49956379
Ileus paralytic 19.42 10.65 14 646063 4036 49955011
Proteinuria 19.38 10.65 128 645949 16469 49942578
Injection site rash 19.29 10.65 302 645775 15875 49943172
Eosinophilia 19.28 10.65 149 645928 18503 49940544
Gait spastic 19.17 10.65 20 646057 241 49958806
Electrocardiogram QRS complex prolonged 19.15 10.65 24 646053 5320 49953727
Full blood count decreased 19.15 10.65 396 645681 21950 49937097
Pulmonary congestion 19.14 10.65 115 645962 15132 49943915
Tonsillectomy 19.11 10.65 35 646042 740 49958307
Small for dates baby 19.06 10.65 92 645985 3413 49955634
Increased tendency to bruise 19.06 10.65 193 645884 9163 49949884
Intervertebral disc protrusion 19.02 10.65 366 645711 20027 49939020
Irritability 19.01 10.65 252 645825 28174 49930873
Cystitis 18.97 10.65 722 645355 43842 49915205
Acute coronary syndrome 18.95 10.65 59 646018 9315 49949732
Osteoporotic fracture 18.90 10.65 85 645992 3060 49955987
Rotator cuff syndrome 18.87 10.65 228 645849 11316 49947731
Epstein-Barr virus infection 18.85 10.65 38 646039 6959 49952088
Hyperbilirubinaemia 18.81 10.65 61 646016 9509 49949538
Bradyphrenia 18.73 10.65 31 646046 6121 49952926
Sleep disorder due to general medical condition, insomnia type 18.68 10.65 530 645547 30917 49928130
Hypomagnesaemia 18.68 10.65 197 645880 22959 49936088
Tumour lysis syndrome 18.58 10.65 42 646035 7379 49951668
Fibula fracture 18.55 10.65 82 645995 2930 49956117
Invasive ductal breast carcinoma 18.31 10.65 134 645943 5787 49953260
Purpura 18.24 10.65 65 646012 9846 49949201
Red blood cell count decreased 18.14 10.65 563 645514 33272 49925775
Gingival disorder 18.06 10.65 85 645992 3120 49955927
Fibromyalgia 18.04 10.65 724 645353 44254 49914793
Pulmonary arterial hypertension 18.00 10.65 169 645908 20150 49938897
Acute myocardial infarction 17.98 10.65 264 645813 29009 49930038
Smear cervix abnormal 17.94 10.65 76 646001 2665 49956382
Surgery 17.93 10.65 509 645568 29696 49929351
Dyskinesia 17.91 10.65 249 645828 27612 49931435
Catatonia 17.80 10.65 13 646064 3723 49955324
Anti-neutrophil cytoplasmic antibody positive vasculitis 17.63 10.65 4 646073 2318 49956729
Oral infection 17.57 10.65 101 645976 4013 49955034
Rash erythematous 17.56 10.65 326 645751 34526 49924521
Toothache 17.43 10.65 308 645769 16586 49942461
Metastases to lymph nodes 17.39 10.65 40 646037 6984 49952063
Bone graft 17.36 10.65 35 646042 797 49958250
Catheter site erythema 17.35 10.65 15 646062 3947 49955100
Spinal stenosis 17.33 10.65 256 645821 13294 49945753
Limb reduction defect 17.31 10.65 23 646054 364 49958683
Drug level increased 17.18 10.65 160 645917 19108 49939939
Medication error 17.18 10.65 341 645736 35763 49923284
Ventricular septal defect 17.12 10.65 99 645978 3942 49955105
Injection site bruising 16.94 10.65 601 645476 36167 49922880
Latent tuberculosis 16.92 10.65 65 646012 2178 49956869
Prothrombin time prolonged 16.91 10.65 57 646020 8781 49950266
Abdominal pain 16.90 10.65 2703 643374 233525 49725522
Myocarditis 16.80 10.65 49 646028 7898 49951149
Decreased appetite 16.78 10.65 2278 643799 198645 49760402
Neutropenic colitis 16.76 10.65 5 646072 2412 49956635
Angina unstable 16.75 10.65 38 646039 6668 49952379
Folate deficiency 16.72 10.65 59 646018 1896 49957151
Cyst 16.68 10.65 233 645844 11954 49947093
Rotator cuff repair 16.62 10.65 54 646023 1662 49957385
Musculoskeletal discomfort 16.60 10.65 275 645802 14623 49944424
Haemodynamic instability 16.58 10.65 50 646027 7974 49951073
Hypercholesterolaemia 16.53 10.65 225 645852 11478 49947569
Pneumothorax 16.51 10.65 108 645969 13926 49945121
Generalised oedema 16.49 10.65 105 645972 13626 49945421
Calcium deficiency 16.40 10.65 37 646040 913 49958134
Nightmare 16.39 10.65 129 645948 15957 49943090
Visual acuity reduced 16.38 10.65 171 645906 19968 49939079
Maternal exposure before pregnancy 16.36 10.65 125 645952 5472 49953575
Wrong product administered 16.32 10.65 27 646050 5333 49953714
Blood parathyroid hormone increased 16.31 10.65 76 646001 2778 49956269
Cytokine release syndrome 16.31 10.65 56 646021 8578 49950469
Hallucinations, mixed 16.25 10.65 17 646060 4086 49954961
Product substitution issue 16.12 10.65 109 645968 13948 49945099
Weight decreased 16.12 10.65 3131 642946 218114 49740933
Diabetic ketoacidosis 16.11 10.65 148 645929 17724 49941323
Oral herpes 16.07 10.65 362 645715 20363 49938684
Liver function test abnormal 16.00 10.65 437 645640 43902 49915145
Ileus 15.97 10.65 101 645976 13128 49945919
Atrioventricular block 15.95 10.65 37 646040 6441 49952606
Chest pain 15.91 10.65 1996 644081 174886 49784161
Hyperthermia 15.87 10.65 48 646029 7648 49951399
Prescribed underdose 15.83 10.65 289 645788 15660 49943387
Paranoia 15.81 10.65 73 646004 10275 49948772
Arrhythmia 15.74 10.65 313 645764 32819 49926228
Paradoxical drug reaction 15.74 10.65 14 646063 3633 49955414
Cataract operation 15.68 10.65 98 645979 4013 49955034
Complication associated with device 15.65 10.65 116 645961 14539 49944508
Ankle fracture 15.64 10.65 285 645792 15437 49943610
Parkinsonism 15.64 10.65 59 646018 8788 49950259
Tenosynovitis stenosans 15.60 10.65 63 646014 2161 49956886
Urticaria 15.52 10.65 1433 644644 128128 49830919
Right ventricular failure 15.48 10.65 129 645948 15764 49943283
Heart rate increased 15.46 10.65 817 645260 76433 49882614
Squamous cell carcinoma 15.45 10.65 159 645918 7580 49951467
Plantar fasciitis 15.40 10.65 76 646001 2845 49956202
Joint dislocation 15.38 10.65 232 645845 12101 49946946
Incorrect route of product administration 15.38 10.65 158 645919 18508 49940539
Jaw disorder 15.36 10.65 112 645965 4831 49954216
Vitamin D increased 15.34 10.65 27 646050 553 49958494
Cold type haemolytic anaemia 15.33 10.65 16 646061 193 49958854
Oedema peripheral 15.27 10.65 1774 644303 156187 49802860
Wheezing 15.24 10.65 642 645435 61405 49897642
Injection site pain 15.23 10.65 1630 644447 109394 49849653
Leukocytosis 15.16 10.65 200 645877 22379 49936668
Peripheral sensory neuropathy 15.16 10.65 39 646038 6552 49952495
Atrioventricular block complete 15.14 10.65 45 646032 7210 49951837
Hyperammonaemia 15.14 10.65 23 646054 4701 49954346
Ligament sprain 15.13 10.65 203 645874 10322 49948725
Adenovirus infection 15.12 10.65 11 646066 3157 49955890
Joint stiffness 15.12 10.65 500 645577 29808 49929239
Blood urea increased 15.08 10.65 211 645866 23374 49935673
Humerus fracture 14.97 10.65 156 645921 7462 49951585
Tenderness 14.94 10.65 326 645751 18239 49940808
Eosinophil count increased 14.89 10.65 60 646017 8770 49950277
Limb deformity 14.87 10.65 90 645987 3644 49955403
Chronic kidney disease 14.86 10.65 390 645687 39381 49919666
Pulse absent 14.83 10.65 24 646053 4782 49954265
Meniscus injury 14.81 10.65 134 645943 6168 49952879
Gastrointestinal toxicity 14.77 10.65 23 646054 4654 49954393
Grip strength decreased 14.73 10.65 227 645850 11894 49947153
Polyhydramnios 14.72 10.65 58 646019 1967 49957080
Ear infection 14.69 10.65 435 645642 25535 49933512
Mouth ulceration 14.67 10.65 465 645612 27559 49931488
Skin toxicity 14.63 10.65 17 646060 3896 49955151
Joint noise 14.63 10.65 87 645990 3500 49955547
Cardiac failure acute 14.59 10.65 55 646022 8195 49950852
Hepatic necrosis 14.57 10.65 28 646049 5220 49953827
Hypersensitivity 14.56 10.65 3034 643043 212127 49746920
Pulmonary alveolar haemorrhage 14.52 10.65 18 646059 4009 49955038
Pulmonary haemorrhage 14.48 10.65 39 646038 6453 49952594
Anger 14.48 10.65 85 645992 11248 49947799
Forced expiratory volume decreased 14.47 10.65 21 646056 4373 49954674
Second primary malignancy 14.35 10.65 43 646034 6871 49952176
Lumbar radiculopathy 14.34 10.65 52 646025 1694 49957353
Hypervolaemia 14.29 10.65 234 645843 25265 49933782
Pericardial effusion 14.28 10.65 235 645842 25354 49933693
Acute respiratory failure 14.26 10.65 270 645807 28512 49930535
Spinal compression fracture 14.24 10.65 234 645843 12422 49946625
Drug use disorder 14.24 10.65 11 646066 3061 49955986
Hypoglycaemic coma 14.17 10.65 6 646071 2327 49956720
Upper limb fracture 14.17 10.65 283 645794 15590 49943457
Edentulous 14.14 10.65 17 646060 242 49958805
Joint destruction 14.10 10.65 92 645985 3824 49955223
Chest discomfort 14.10 10.65 1006 645071 91716 49867331
Endophthalmitis 14.08 10.65 10 646067 2906 49956141
Blood pressure diastolic abnormal 14.06 10.65 182 645895 9179 49949868
Withdrawal syndrome 14.04 10.65 150 645927 17440 49941607
Affect lability 14.03 10.65 63 646014 8935 49950112
Metabolic disorder 13.99 10.65 29 646048 5257 49953790
Dizziness 13.92 10.65 4077 642000 342292 49616755
Generalised tonic-clonic seizure 13.91 10.65 244 645833 26066 49932981
Personality disorder 13.91 10.65 21 646056 4303 49954744
Disturbance in social behaviour 13.88 10.65 10 646067 2884 49956163
Hyperaesthesia teeth 13.87 10.65 47 646030 1479 49957568
Tonsillitis 13.87 10.65 109 645968 4814 49954233
Blood pH decreased 13.85 10.65 7 646070 2448 49956599
Myocardial ischaemia 13.85 10.65 89 645988 11524 49947523
Nodule 13.82 10.65 299 645778 16704 49942343
Dysphoria 13.67 10.65 25 646052 4749 49954298
Limb injury 13.66 10.65 347 645730 19903 49939144
Hypoalbuminaemia 13.66 10.65 72 646005 9788 49949259
Reversible cerebral vasoconstriction syndrome 13.61 10.65 5 646072 2114 49956933
Abscess oral 13.59 10.65 43 646034 1305 49957742
Appendicectomy 13.57 10.65 66 646011 2456 49956591
Seasonal allergy 13.55 10.65 263 645814 14413 49944634
Gait disturbance 13.55 10.65 2147 643930 147858 49811189
Gastroenteritis astroviral 13.50 10.65 4 646073 0 49959047
Hypophagia 13.46 10.65 261 645816 27467 49931580
Patellofemoral pain syndrome 13.45 10.65 25 646052 535 49958512
Muscle injury 13.44 10.65 591 645486 36520 49922527
Tooth infection 13.41 10.65 254 645823 13858 49945189
Inadequate analgesia 13.41 10.65 8 646069 2550 49956497
Hallucination, visual 13.40 10.65 141 645936 16441 49942606
Sudden death 13.40 10.65 64 646013 8927 49950120
Treatment noncompliance 13.39 10.65 288 645789 29862 49929185
Graft versus host disease in skin 13.39 10.65 8 646069 2548 49956499
Catheter site pain 13.37 10.65 17 646060 3745 49955302
Milk-alkali syndrome 13.33 10.65 28 646049 657 49958390
Oral disorder 13.29 10.65 156 645921 7688 49951359
Hepatitis B reactivation 13.28 10.65 5 646072 2082 49956965
Nephropathy toxic 13.27 10.65 55 646022 7974 49951073
Knee operation 13.24 10.65 107 645970 4766 49954281
Hypoaesthesia 13.22 10.65 1836 644241 125421 49833626
Colitis microscopic 13.21 10.65 41 646036 6479 49952568
Blood iron increased 13.21 10.65 43 646034 1325 49957722
Persecutory delusion 13.18 10.65 7 646070 2380 49956667
Flushing 13.17 10.65 710 645367 66305 49892742
Sciatica 13.16 10.65 362 645715 21020 49938027
Activated partial thromboplastin time prolonged 13.15 10.65 40 646037 6362 49952685
Isosthenuria 13.13 10.65 11 646066 98 49958949
Bursitis 13.13 10.65 373 645704 21762 49937285
Muscle spasms 13.11 10.65 1812 644265 123741 49835306
Cyst removal 13.11 10.65 21 646056 397 49958650
Osteochondrosis 13.01 10.65 37 646040 1057 49957990
Maternal drugs affecting foetus 13.00 10.65 110 645967 4967 49954080
Nephrogenic systemic fibrosis 12.95 10.65 22 646055 4300 49954747
Acidosis 12.91 10.65 77 646000 10150 49948897
Pseudomembranous colitis 12.87 10.65 10 646067 2775 49956272
Hungry bone syndrome 12.79 10.65 10 646067 80 49958967
Circulatory collapse 12.76 10.65 179 645898 19821 49939226
Neck mass 12.75 10.65 80 645997 3281 49955766
Ischaemic stroke 12.73 10.65 136 645941 15812 49943235
Haemorrhage intracranial 12.72 10.65 99 645978 12275 49946772
Pharyngitis streptococcal 12.71 10.65 170 645907 8638 49950409
Biopsy breast 12.71 10.65 17 646060 271 49958776
Clear cell renal cell carcinoma 12.70 10.65 39 646038 1164 49957883
Squamous cell carcinoma of skin 12.63 10.65 111 645966 5067 49953980
Intestinal stenosis 12.63 10.65 65 646012 2475 49956572
Limb hypoplasia congenital 12.61 10.65 14 646063 182 49958865
Eye infection 12.54 10.65 179 645898 9227 49949820
Pancreatitis acute 12.54 10.65 221 645856 23591 49935456
Traumatic arthritis 12.52 10.65 7 646070 29 49959018
Irritable bowel syndrome 12.52 10.65 789 645288 50652 49908395
Hernia 12.48 10.65 181 645896 9362 49949685
Catheter management 12.45 10.65 10 646067 2729 49956318
Tubulointerstitial nephritis 12.43 10.65 129 645948 15082 49943965
Periodontal disease 12.43 10.65 45 646032 1465 49957582
Thyroid mass 12.42 10.65 81 645996 3367 49955680
Disturbance in attention 12.41 10.65 303 645774 30883 49928164
Scleritis 12.36 10.65 77 646000 3150 49955897
Essential hypertension 12.30 10.65 98 645979 4346 49954701
Peripheral venous disease 12.29 10.65 117 645960 5463 49953584
Rib fracture 12.28 10.65 327 645750 18894 49940153
Synovial disorder 12.27 10.65 32 646045 868 49958179
Device failure 12.22 10.65 116 645961 5412 49953635
Groin pain 12.18 10.65 170 645907 8721 49950326
Disability 12.16 10.65 230 645847 12545 49946502
Liver transplant 12.15 10.65 6 646071 2126 49956921
Acute lymphocytic leukaemia recurrent 12.13 10.65 5 646072 1970 49957077
Hysterectomy 12.11 10.65 154 645923 7736 49951311
Mitral valve prolapse 12.10 10.65 57 646020 2093 49956954
Acute graft versus host disease in intestine 12.10 10.65 3 646074 1636 49957411
Heart rate decreased 12.09 10.65 576 645501 35921 49923126
Congenital arterial malformation 12.06 10.65 18 646059 319 49958728
Dairy intolerance 12.04 10.65 8 646069 48 49958999
Osteonecrosis of jaw 12.01 10.65 519 645558 32007 49927040
Biliary dyskinesia 11.99 10.65 9 646068 2541 49956506
Drug intolerance 11.93 10.65 3059 643018 216045 49743002
Arthritis infective 11.88 10.65 116 645961 5453 49953594
Scapula fracture 11.87 10.65 20 646057 395 49958652
Basosquamous carcinoma 11.84 10.65 5 646072 9 49959038
Appendix disorder 11.81 10.65 42 646035 1355 49957692
Enthesopathy 11.73 10.65 142 645935 7051 49951996
Systemic candida 11.70 10.65 11 646066 2779 49956268
Post procedural hypothyroidism 11.68 10.65 11 646066 116 49958931
Type IIa hyperlipidaemia 11.68 10.65 11 646066 116 49958931
Breast disorder 11.67 10.65 54 646023 1968 49957079
Blood pressure systolic abnormal 11.65 10.65 150 645927 7556 49951491
Renal tubular necrosis 11.58 10.65 79 645998 10089 49948958
Sexual dysfunction 11.58 10.65 15 646062 3277 49955770
Parathyroid tumour benign 11.56 10.65 25 646052 599 49958448
Crush syndrome 11.54 10.65 11 646066 118 49958929
Periodontal operation 11.52 10.65 7 646070 35 49959012
Knee deformity 11.51 10.65 34 646043 993 49958054
Rectocele 11.50 10.65 31 646046 858 49958189
Anaphylactoid reaction 11.49 10.65 16 646061 3390 49955657
Exostosis of jaw 11.49 10.65 38 646039 1181 49957866
Enterocolitis 11.47 10.65 44 646033 6523 49952524
Blood lactate dehydrogenase increased 11.47 10.65 178 645899 19384 49939663
Ligament rupture 11.47 10.65 65 646012 2569 49956478
Red blood cell sedimentation rate increased 11.45 10.65 472 645605 28944 49930103
Transaminases increased 11.44 10.65 269 645808 27555 49931492
Dialysis 11.42 10.65 72 646005 9366 49949681
Osteomalacia 11.41 10.65 26 646051 646 49958401
Breast feeding 11.40 10.65 30 646047 818 49958229
Accidental death 11.40 10.65 4 646073 1740 49957307
Dyspnoea exertional 11.38 10.65 536 645541 50697 49908350
Bladder hypertrophy 11.35 10.65 14 646063 205 49958842
Hepatitis cholestatic 11.34 10.65 40 646037 6077 49952970
Fibrocystic breast disease 11.31 10.65 35 646042 1049 49957998
Kidney transplant rejection 11.31 10.65 21 646056 3966 49955081
Gallbladder operation 11.28 10.65 53 646024 1944 49957103
Blood calcium decreased 11.28 10.65 191 645886 20515 49938532
Closed fracture manipulation 11.28 10.65 6 646071 22 49959025
International normalised ratio fluctuation 11.27 10.65 7 646070 2183 49956864
Pulmonary toxicity 11.25 10.65 35 646042 5527 49953520
Steroid therapy 11.22 10.65 9 646068 75 49958972
Drug eruption 11.22 10.65 223 645854 23383 49935664
Amenorrhoea 11.18 10.65 63 646014 8421 49950626
Coeliac disease 11.17 10.65 65 646012 8620 49950427
Pupil fixed 11.15 10.65 3 646074 1549 49957498
Atrial septal defect 11.14 10.65 127 645950 6214 49952833
Uterine prolapse 11.14 10.65 36 646041 1105 49957942
Therapeutic product effect incomplete 11.13 10.65 1011 645066 90504 49868543
Premature rupture of membranes 11.08 10.65 98 645979 4482 49954565
Premature labour 11.06 10.65 207 645870 11269 49947778
Diverticulitis 11.06 10.65 524 645553 32658 49926389
Hypervitaminosis D 11.03 10.65 9 646068 77 49958970
Gingival recession 11.02 10.65 39 646038 1255 49957792
Upper respiratory tract infection 11.02 10.65 981 645096 64917 49894130
Congenital oral malformation 10.98 10.65 13 646064 182 49958865
Shock haemorrhagic 10.97 10.65 62 646015 8282 49950765
Congestive cardiomyopathy 10.97 10.65 35 646042 5483 49953564
Dermatitis acneiform 10.96 10.65 22 646055 4035 49955012
Haemorrhage subcutaneous 10.92 10.65 11 646066 2690 49956357
Floating patella 10.90 10.65 5 646072 12 49959035
Complication of device removal 10.89 10.65 23 646054 4141 49954906
Temporomandibular joint syndrome 10.89 10.65 80 645997 3459 49955588
Complication of device insertion 10.86 10.65 40 646037 6001 49953046
Oliguria 10.83 10.65 61 646016 8155 49950892
Erythema 10.83 10.65 1672 644405 144742 49814305
Wheelchair user 10.82 10.65 104 645973 4868 49954179
Bladder operation 10.77 10.65 29 646048 802 49958245
Hepatitis fulminant 10.77 10.65 14 646063 3054 49955993
Hemiplegia 10.73 10.65 53 646024 7328 49951719
Tooth abscess 10.73 10.65 227 645850 12633 49946414
Pre-eclampsia 10.69 10.65 153 645924 7891 49951156
Acute chest syndrome 10.69 10.65 25 646052 632 49958415
Acute pulmonary oedema 10.67 10.65 52 646025 7215 49951832
Hospitalisation 10.67 10.65 735 645342 67202 49891845
Chest wall tumour 10.66 10.65 7 646070 41 49959006

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Toxicity to various agents 519.23 10.48 426 250077 173235 29150789
Drug abuse 444.05 10.48 72 250431 79811 29244213
Completed suicide 424.90 10.48 119 250384 90127 29233897
Rheumatoid arthritis 289.71 10.48 757 249746 31395 29292629
Drug interaction 196.94 10.48 931 249572 196454 29127570
Intentional overdose 156.60 10.48 65 250438 38463 29285561
Foetal exposure during pregnancy 148.03 10.48 624 249879 33243 29290781
Arthralgia 132.40 10.48 1783 248720 137834 29186190
Fatigue 128.67 10.48 3551 246952 313270 29010754
Hepatic function abnormal 119.88 10.48 94 250409 39165 29284859
Overdose 118.49 10.48 318 250185 79501 29244523
Infective pulmonary exacerbation of cystic fibrosis 109.95 10.48 193 250310 6043 29317981
Psoriatic arthropathy 105.82 10.48 319 250184 14372 29309652
Suicide attempt 98.79 10.48 86 250417 34024 29290000
Psoriasis 91.47 10.48 525 249978 31702 29292322
Drug resistance 88.07 10.48 36 250467 21504 29302520
Acute kidney injury 86.58 10.48 1655 248848 263612 29060412
Death 80.57 10.48 2245 248258 339839 28984185
Dysmorphism 80.40 10.48 112 250391 2859 29321165
Drug reaction with eosinophilia and systemic symptoms 79.34 10.48 72 250431 27920 29296104
Coma 77.79 10.48 134 250369 39316 29284708
Fall 77.66 10.48 2007 248496 175171 29148853
Renal failure 76.29 10.48 640 249863 117959 29206065
Multiple organ dysfunction syndrome 76.27 10.48 276 250227 62840 29261184
Rhabdomyolysis 76.09 10.48 262 250241 60546 29263478
Cardiac arrest 74.26 10.48 423 250080 85168 29238856
Respiratory arrest 71.39 10.48 68 250435 25765 29298259
Multiple sclerosis relapse 69.50 10.48 234 250269 11185 29312839
Nasopharyngitis 69.35 10.48 792 249711 58873 29265151
Peripheral swelling 65.72 10.48 827 249676 62912 29261112
Serotonin syndrome 64.27 10.48 34 250469 17478 29306546
Sickle cell anaemia with crisis 64.23 10.48 94 250409 2514 29321510
Product dose omission issue 59.95 10.48 1148 249355 95235 29228789
Joint swelling 59.12 10.48 662 249841 48968 29275056
Cytomegalovirus infection 56.46 10.48 68 250435 23147 29300877
Speech disorder developmental 56.32 10.48 75 250428 1832 29322192
Toxic epidermal necrolysis 55.99 10.48 43 250460 18110 29305914
Basal cell carcinoma 55.74 10.48 287 250216 16623 29307401
Product use in unapproved indication 55.29 10.48 470 250033 86405 29237619
Febrile neutropenia 54.50 10.48 648 249855 111592 29212432
Blood pressure fluctuation 53.78 10.48 320 250183 19574 29304450
Pain 50.69 10.48 1851 248652 169581 29154443
Disseminated intravascular coagulation 49.15 10.48 58 250445 19922 29304102
Depressed level of consciousness 48.37 10.48 156 250347 36786 29287238
Lactic acidosis 48.32 10.48 116 250387 30131 29293893
Shock 46.64 10.48 68 250435 21336 29302688
Enthesopathy 45.44 10.48 99 250404 3644 29320380
Vitamin D deficiency 44.56 10.48 125 250378 5404 29318620
Altered state of consciousness 44.51 10.48 62 250441 19827 29304197
Hepatic failure 44.15 10.48 129 250374 31383 29292641
Poisoning 43.70 10.48 15 250488 9978 29314046
Cardio-respiratory arrest 43.36 10.48 251 250252 50350 29273674
Pathogen resistance 41.45 10.48 9 250494 8107 29315917
Drug withdrawal syndrome 41.32 10.48 55 250448 17929 29306095
Weight decreased 40.91 10.48 1614 248889 149291 29174733
Intentional product misuse 40.91 10.48 153 250350 34508 29289516
Angioedema 40.25 10.48 137 250366 31778 29292246
Tenosynovitis 40.04 10.48 94 250409 3639 29320385
Musculoskeletal stiffness 39.87 10.48 489 250014 36969 29287055
Foetal anticonvulsant syndrome 39.43 10.48 49 250454 1115 29322909
Stevens-Johnson syndrome 39.40 10.48 49 250454 16448 29307576
Maternal exposure during pregnancy 39.09 10.48 99 250404 4024 29320000
Neonatal respiratory distress syndrome 38.78 10.48 94 250409 3716 29320308
Sedation 38.21 10.48 55 250448 17350 29306674
Sinusitis 38.12 10.48 452 250051 33898 29290126
Bone giant cell tumour 37.59 10.48 13 250490 19 29324005
Osteoarthritis 37.27 10.48 272 250231 17831 29306193
Back pain 36.44 10.48 1129 249374 101155 29222869
Atrial septal defect 36.04 10.48 133 250370 6656 29317368
Hypospadias 35.99 10.48 79 250424 2923 29321101
Premature baby 35.21 10.48 259 250244 17021 29307003
Blood creatine phosphokinase increased 35.15 10.48 201 250302 40443 29283581
Colitis ulcerative 34.90 10.48 206 250297 12563 29311461
Cough 34.00 10.48 1354 249149 125373 29198651
Substance abuse 33.72 10.48 8 250495 6779 29317245
Neuroleptic malignant syndrome 33.54 10.48 53 250450 16095 29307929
Vitamin D decreased 32.85 10.48 75 250428 2850 29321174
Hypoglycaemia neonatal 32.54 10.48 55 250448 1669 29322355
Autism spectrum disorder 32.14 10.48 60 250443 1972 29322052
Hypotension 32.09 10.48 1333 249170 193021 29131003
Interstitial lung disease 31.65 10.48 324 250179 57394 29266630
Cryptorchism 31.54 10.48 58 250445 1884 29322140
Neurotoxicity 31.28 10.48 47 250456 14566 29309458
General physical health deterioration 30.69 10.48 1112 249391 101745 29222279
Nephrolithiasis 30.64 10.48 339 250164 24995 29299029
Blood iron decreased 30.54 10.48 95 250408 4353 29319671
Post transplant lymphoproliferative disorder 30.38 10.48 5 250498 5488 29318536
Exposure during pregnancy 30.18 10.48 148 250355 8406 29315618
Mucormycosis 30.13 10.48 4 250499 5154 29318870
Relapsing-remitting multiple sclerosis 30.06 10.48 34 250469 698 29323326
Wound 30.05 10.48 190 250313 11873 29312151
Arthritis 29.90 10.48 334 250169 24685 29299339
Learning disorder 29.88 10.48 40 250463 982 29323042
Juvenile idiopathic arthritis 29.74 10.48 47 250456 1347 29322677
Drug ineffective 29.71 10.48 2661 247842 360509 28963515
Skin cancer 29.51 10.48 146 250357 8322 29315702
Status epilepticus 29.14 10.48 29 250474 10765 29313259
Cardiac failure 29.12 10.48 484 250019 78803 29245221
Small for dates baby 28.93 10.48 81 250422 3498 29320526
Maternal exposure during breast feeding 28.84 10.48 48 250455 1438 29322586
Myocardial infarction 28.65 10.48 713 249790 109583 29214441
Maternal drugs affecting foetus 28.47 10.48 85 250418 3808 29320216
Memory impairment 28.24 10.48 450 250053 36020 29288004
Rash maculo-papular 28.15 10.48 108 250395 24181 29299843
Suicidal ideation 27.74 10.48 176 250327 34540 29289484
Intentional self-injury 27.73 10.48 39 250464 12422 29311602
Multiple sclerosis 27.16 10.48 106 250397 5448 29318576
Osteoporosis 27.07 10.48 170 250333 10599 29313425
Electrocardiogram QT prolonged 26.97 10.48 187 250316 35950 29288074
Neutropenia 26.96 10.48 880 249623 130831 29193193
Syndactyly 26.86 10.48 33 250470 742 29323282
Acute graft versus host disease 26.78 10.48 8 250495 5816 29318208
Balance disorder 26.78 10.48 443 250060 35727 29288297
Acute respiratory distress syndrome 26.57 10.48 102 250401 22833 29301191
Cataract 26.40 10.48 298 250205 22080 29301944
Influenza 26.05 10.48 499 250004 41382 29282642
Psychotic disorder 25.92 10.48 87 250416 20267 29303757
Palmar-plantar erythrodysaesthesia syndrome 25.69 10.48 54 250449 14705 29309319
Red cell distribution width increased 25.65 10.48 93 250410 4614 29319410
Pain in extremity 25.57 10.48 1162 249341 109271 29214753
Respiratory failure 25.46 10.48 627 249876 96504 29227520
Disease progression 25.40 10.48 515 249988 81401 29242623
Agitation 25.33 10.48 295 250208 51009 29273015
Acute hepatic failure 25.04 10.48 39 250464 11913 29312111
Musculoskeletal pain 25.02 10.48 364 250139 28589 29295435
Gait spastic 24.92 10.48 30 250473 660 29323364
Joint laxity 24.64 10.48 23 250480 373 29323651
Venoocclusive liver disease 24.55 10.48 14 250489 6903 29317121
Low birth weight baby 24.51 10.48 116 250387 6492 29317532
Foetal malformation 24.45 10.48 15 250488 123 29323901
Hepatitis 24.35 10.48 92 250411 20691 29303333
Vomiting 24.21 10.48 1512 248991 210748 29113276
Renal impairment 24.13 10.48 515 249988 80818 29243206
Intellectual disability 23.79 10.48 38 250465 1099 29322925
Suspected suicide 23.77 10.48 3 250500 4017 29320007
Sopor 23.56 10.48 35 250468 10899 29313125
Cystitis haemorrhagic 23.48 10.48 6 250497 4836 29319188
Immune reconstitution inflammatory syndrome 23.41 10.48 19 250484 7783 29316241
Foot deformity 23.31 10.48 81 250422 3934 29320090
Urinary tract infection 23.25 10.48 789 249714 71565 29252459
Red blood cell count decreased 22.97 10.48 324 250179 25278 29298746
Thrombocytopenia 22.79 10.48 922 249581 133901 29190123
Brain oedema 22.74 10.48 43 250460 12177 29311847
Hypoglycaemia 22.71 10.48 281 250222 48065 29275959
Hypermobility syndrome 22.67 10.48 21 250482 337 29323687
Hyperkalaemia 22.46 10.48 375 250128 61017 29263007
Astigmatism 22.35 10.48 34 250469 942 29323082
Hepatotoxicity 22.32 10.48 77 250426 17790 29306234
Jaundice neonatal 22.30 10.48 39 250464 1217 29322807
Squamous cell carcinoma of skin 22.15 10.48 147 250356 9339 29314685
Attention deficit hyperactivity disorder 21.82 10.48 54 250449 2163 29321861
Haematotoxicity 21.79 10.48 15 250488 6684 29317340
Acute generalised exanthematous pustulosis 21.76 10.48 10 250493 5573 29318451
Language disorder 21.75 10.48 50 250453 1909 29322115
Bradycardia 21.74 10.48 408 250095 65221 29258803
Eosinophilia 21.73 10.48 105 250398 22056 29301968
Aspergillus infection 21.72 10.48 35 250468 10546 29313478
Bronchopulmonary aspergillosis 21.63 10.48 45 250458 12299 29311725
Victim of child abuse 21.60 10.48 31 250472 814 29323210
Folate deficiency 21.57 10.48 36 250467 1081 29322943
Malignant neoplasm progression 21.53 10.48 469 250034 73390 29250634
Needle fatigue 21.52 10.48 26 250477 574 29323450
Unresponsive to stimuli 21.32 10.48 125 250378 25001 29299023
Poisoning deliberate 21.22 10.48 11 250492 5720 29318304
Posterior reversible encephalopathy syndrome 21.08 10.48 27 250476 8949 29315075
Ear infection 21.07 10.48 129 250374 7971 29316053
Polydactyly 21.03 10.48 36 250467 1104 29322920
Upper respiratory tract infection 21.00 10.48 337 250166 27012 29297012
Drug dependence 20.81 10.48 99 250404 20882 29303142
Mean cell volume increased 20.78 10.48 57 250446 2432 29321592
Anaphylactic shock 20.63 10.48 52 250451 13284 29310740
Joint effusion 20.58 10.48 80 250423 4104 29319920
Congenital hand malformation 20.56 10.48 25 250478 556 29323468
Urticaria 20.28 10.48 333 250170 54327 29269697
Full blood count decreased 20.26 10.48 216 250287 15776 29308248
Dystonia 20.25 10.48 32 250471 9717 29314307
Spinal fracture 19.94 10.48 108 250395 6378 29317646
Serum ferritin increased 19.94 10.48 97 250406 5491 29318533
Ventricular fibrillation 19.94 10.48 68 250435 15765 29308259
Nephropathy toxic 19.88 10.48 38 250465 10718 29313306
Vitamin B12 deficiency 19.87 10.48 67 250436 3204 29320820
Muscle spasticity 19.81 10.48 88 250415 4795 29319229
Trisomy 18 19.68 10.48 15 250488 181 29323843
Melanoderma 19.66 10.48 14 250489 151 29323873
Inguinal hernia 19.65 10.48 110 250393 6578 29317446
Pulmonary fibrosis 19.53 10.48 210 250293 15372 29308652
Chronic graft versus host disease 19.53 10.48 5 250498 4024 29320000
Body height decreased 19.51 10.48 69 250434 3381 29320643
Pyrexia 19.49 10.48 2136 248367 285486 29038538
Ventricular septal defect 19.46 10.48 70 250433 3459 29320565
Back disorder 19.42 10.48 101 250402 5872 29318152
Developmental delay 19.39 10.48 56 250447 2462 29321562
Exposure via breast milk 19.34 10.48 44 250459 1668 29322356
Delirium 19.26 10.48 227 250276 39170 29284854
Alanine aminotransferase abnormal 19.25 10.48 62 250441 2895 29321129
Intervertebral disc degeneration 19.23 10.48 92 250411 5172 29318852
Somnolence 19.15 10.48 628 249875 93327 29230697
Talipes 19.09 10.48 45 250458 1747 29322277
Drug eruption 19.04 10.48 75 250428 16666 29307358
Oesophageal adenocarcinoma 18.91 10.48 28 250475 757 29323267
Ventricular tachycardia 18.79 10.48 113 250390 22461 29301563
Cardiogenic shock 18.77 10.48 91 250412 19099 29304925
Acute graft versus host disease in skin 18.73 10.48 8 250495 4656 29319368
Hyperthermia 18.61 10.48 32 250471 9398 29314626
Poor venous access 18.55 10.48 64 250439 3097 29320927
Aplastic anaemia 18.53 10.48 118 250385 7392 29316632
Coronary artery disease 18.51 10.48 263 250240 43927 29280097
Tongue disorder 18.39 10.48 83 250420 4553 29319471
Electrocardiogram QRS complex prolonged 18.27 10.48 6 250497 4104 29319920
Hypertonic bladder 18.24 10.48 39 250464 1417 29322607
Bronchial secretion retention 18.18 10.48 34 250469 1119 29322905
Rheumatoid nodule 18.12 10.48 49 250454 2073 29321951
Pancreatic failure 18.05 10.48 26 250477 685 29323339
Motor developmental delay 18.04 10.48 25 250478 635 29323389
Metabolic acidosis 18.03 10.48 218 250285 37444 29286580
Malignant melanoma 17.97 10.48 113 250390 7048 29316976
Graft versus host disease in gastrointestinal tract 17.94 10.48 3 250500 3255 29320769
Melaena 17.92 10.48 173 250330 31003 29293021
Cardiotoxicity 17.72 10.48 9 250494 4735 29319289
Large for dates baby 17.68 10.48 29 250474 858 29323166
C-reactive protein abnormal 17.57 10.48 105 250398 6431 29317593
Myoclonus 17.56 10.48 56 250447 13253 29310771
Hypochromasia 17.43 10.48 17 250486 292 29323732
Cerebral haemorrhage 17.39 10.48 176 250327 31250 29292774
Pulmonary alveolar haemorrhage 17.38 10.48 17 250486 6363 29317661
Dysgraphia 17.34 10.48 47 250456 1991 29322033
Localised infection 17.22 10.48 186 250317 13630 29310394
Tendonitis 17.18 10.48 121 250382 7840 29316184
Septic shock 17.16 10.48 401 250102 62159 29261865
Right atrial hypertrophy 17.07 10.48 22 250481 520 29323504
Pneumonia 17.06 10.48 3020 247483 317152 29006872
Mydriasis 16.83 10.48 16 250487 6069 29317955
Plagiocephaly 16.79 10.48 21 250482 481 29323543
Right ventricular hypertrophy 16.79 10.48 33 250470 1128 29322896
Fracture 16.77 10.48 98 250405 5955 29318069
Angina pectoris 16.67 10.48 153 250350 27697 29296327
Hypertransaminasaemia 16.50 10.48 5 250498 3601 29320423
Knee deformity 16.47 10.48 22 250481 539 29323485
Arthropathy 16.32 10.48 265 250238 21289 29302735
Mobility decreased 16.31 10.48 308 250195 25472 29298552
Haemodynamic instability 16.29 10.48 27 250476 8046 29315978
Miosis 15.97 10.48 27 250476 7982 29316042
Second primary malignancy 15.92 10.48 20 250483 6685 29317339
Nocardiosis 15.89 10.48 4 250499 3256 29320768
Hip fracture 15.86 10.48 147 250356 10345 29313679
Hypophosphatasia 15.82 10.48 7 250496 26 29323998
Kidney infection 15.79 10.48 80 250423 4603 29319421
Aggression 15.79 10.48 209 250294 35332 29288692
Loss of personal independence in daily activities 15.78 10.48 303 250200 25137 29298887
Coagulopathy 15.78 10.48 88 250415 17819 29306205
Plasma cell myeloma 15.77 10.48 419 250084 36696 29287328
Cytomegalovirus chorioretinitis 15.73 10.48 4 250499 3234 29320790
Rhinorrhoea 15.72 10.48 263 250240 21256 29302768
Synovitis 15.67 10.48 151 250352 10739 29313285
Atypical fracture 15.65 10.48 11 250492 116 29323908
Appendicolith 15.61 10.48 5 250498 3475 29320549
Hydrocele 15.59 10.48 44 250459 1909 29322115
Hypercalcaemia 15.55 10.48 171 250332 12588 29311436
Extrapyramidal disorder 15.42 10.48 44 250459 10787 29313237
Congenital hydronephrosis 15.41 10.48 24 250479 679 29323345
Wrong technique in product usage process 15.39 10.48 181 250322 31247 29292777
Withdrawal syndrome 15.39 10.48 45 250458 10947 29313077
Spinal disorder 15.30 10.48 67 250436 3628 29320396
Tumour lysis syndrome 15.29 10.48 63 250440 13821 29310203
Sexual dysfunction 15.26 10.48 16 250487 5798 29318226
Cellulitis 15.26 10.48 502 250001 45338 29278686
Haemodialysis 15.25 10.48 39 250464 9915 29314109
Tooth fracture 15.24 10.48 60 250443 3096 29320928
Blood creatinine increased 15.23 10.48 578 249925 84524 29239500
Multimorbidity 15.13 10.48 21 250482 534 29323490
Akathisia 15.10 10.48 21 250482 6721 29317303
Anal fistula 15.10 10.48 73 250430 4122 29319902
Off label use 15.08 10.48 2277 248226 298523 29025501
Phospholipidosis 15.08 10.48 8 250495 48 29323976
Atrioventricular septal defect 15.07 10.48 12 250491 155 29323869
Cerebral infarction 15.01 10.48 135 250368 24540 29299484
Blood lactic acid increased 14.99 10.48 16 250487 5750 29318274
Blood 25-hydroxycholecalciferol decreased 14.96 10.48 9 250494 71 29323953
Anuria 14.91 10.48 37 250466 9504 29314520
Virologic failure 14.86 10.48 3 250500 2844 29321180
Proteinuria 14.85 10.48 76 250427 15728 29308296
Post procedural infection 14.84 10.48 74 250429 4231 29319793
Tachycardia 14.74 10.48 484 250019 71926 29252098
Central nervous system lesion 14.72 10.48 90 250413 5558 29318466
Sleep apnoea syndrome 14.71 10.48 220 250283 17379 29306645
Blood pressure systolic abnormal 14.70 10.48 46 250457 2115 29321909
Lipodystrophy acquired 14.69 10.48 4 250499 3090 29320934
Drug abuser 14.69 10.48 7 250496 3820 29320204
Grip strength decreased 14.68 10.48 48 250455 2259 29321765
Asphyxia 14.67 10.48 14 250489 5301 29318723
Torsade de pointes 14.67 10.48 21 250482 6640 29317384
Diverticular perforation 14.63 10.48 57 250446 2927 29321097
Dyslexia 14.63 10.48 16 250487 316 29323708
Lower respiratory tract infection 14.56 10.48 310 250193 26192 29297832
Hepatitis fulminant 14.54 10.48 6 250497 3565 29320459
Graft versus host disease 14.54 10.48 38 250465 9590 29314434
Strabismus 14.48 10.48 35 250468 1381 29322643
Hyperbilirubinaemia neonatal 14.44 10.48 24 250479 718 29323306
Hyperammonaemia 14.40 10.48 16 250487 5647 29318377
Immunodeficiency 14.38 10.48 75 250428 4365 29319659
Spinal stenosis 14.34 10.48 74 250429 4289 29319735
Tubulointerstitial nephritis 14.32 10.48 89 250414 17554 29306470
Frequent bowel movements 14.24 10.48 130 250373 9109 29314915
Gastrointestinal stoma complication 14.23 10.48 31 250472 1141 29322883
Upper limb fracture 14.22 10.48 70 250433 3981 29320043
Night sweats 14.22 10.48 191 250312 14741 29309283
Umbilical hernia 14.17 10.48 66 250437 3669 29320355
Contusion 14.07 10.48 354 250149 30741 29293283
Viral acanthoma 14.05 10.48 6 250497 20 29324004
Therapy partial responder 14.00 10.48 14 250489 5185 29318839
Scoliosis 13.88 10.48 47 250456 2253 29321771
Neck pain 13.83 10.48 257 250246 21190 29302834
Dyspraxia 13.78 10.48 17 250486 384 29323640
Myelosuppression 13.76 10.48 55 250448 12172 29311852
Polyarthritis 13.73 10.48 68 250435 3877 29320147
Urge incontinence 13.70 10.48 19 250484 483 29323541
Blood pressure increased 13.64 10.48 760 249743 73043 29250981
Renal aplasia 13.58 10.48 22 250481 644 29323380
Mental status changes 13.55 10.48 211 250292 34716 29289308
Emotional distress 13.52 10.48 66 250437 13829 29310195
Urine calcium/creatinine ratio increased 13.42 10.48 6 250497 23 29324001
Gastrointestinal haemorrhage 13.40 10.48 544 249959 78989 29245035
Polyomavirus-associated nephropathy 13.36 10.48 6 250497 3390 29320634
Thrombotic microangiopathy 13.31 10.48 34 250469 8647 29315377
Cystic fibrosis 13.29 10.48 35 250468 1457 29322567
Lacrimal disorder 13.26 10.48 15 250488 308 29323716
Anal fissure 13.25 10.48 53 250450 2755 29321269
Femur fracture 13.24 10.48 103 250400 6888 29317136
Mania 13.23 10.48 34 250469 8629 29315395
Right atrial enlargement 13.20 10.48 13 250490 226 29323798
Cholelithiasis 13.20 10.48 227 250276 18445 29305579
Phlebitis infective 13.16 10.48 10 250493 120 29323904
Otitis media 13.14 10.48 50 250453 2539 29321485
Medical device implantation 13.12 10.48 20 250483 555 29323469
Disinhibition 13.09 10.48 3 250500 2604 29321420
Diabetic ketoacidosis 13.09 10.48 81 250422 15992 29308032
Rib fracture 13.08 10.48 165 250338 12553 29311471
Behaviour disorder 13.07 10.48 63 250440 3553 29320471
Abdominal adhesions 13.04 10.48 31 250472 1210 29322814
Low turnover osteopathy 13.04 10.48 9 250494 92 29323932
Microcephaly 12.95 10.48 23 250480 727 29323297
Benign prostatic hyperplasia 12.95 10.48 154 250349 11556 29312468
Agranulocytosis 12.94 10.48 110 250393 20230 29303794
Toxic encephalopathy 12.90 10.48 12 250491 4600 29319424
Weight decrease neonatal 12.89 10.48 15 250488 318 29323706
Impaired fasting glucose 12.88 10.48 12 250491 194 29323830
Pancreatitis 12.88 10.48 210 250293 34304 29289720
Selective eating disorder 12.82 10.48 37 250466 1626 29322398
Haemoglobin decreased 12.78 10.48 1075 249428 107300 29216724
Blood test abnormal 12.77 10.48 88 250415 5661 29318363
Productive cough 12.74 10.48 351 250152 30908 29293116
Impaired healing 12.73 10.48 173 250330 13385 29310639
Headache 12.71 10.48 1671 248832 172336 29151688
Febrile bone marrow aplasia 12.71 10.48 27 250476 7324 29316700
Intentional medical device removal by patient 12.69 10.48 12 250491 198 29323826
Drug level increased 12.68 10.48 100 250403 18687 29305337
Anaphylactic reaction 12.67 10.48 161 250342 27412 29296612
Complications of transplanted kidney 12.67 10.48 9 250494 3945 29320079
Intraductal papillary mucinous neoplasm 12.64 10.48 15 250488 325 29323699
Neurodevelopmental disorder 12.64 10.48 15 250488 325 29323699
Urosepsis 12.63 10.48 143 250360 10603 29313421
Bacterial disease carrier 12.62 10.48 17 250486 420 29323604
Tarsal tunnel syndrome 12.60 10.48 5 250498 13 29324011
Apparent death 12.57 10.48 7 250496 3497 29320527
Weight fluctuation 12.54 10.48 68 250435 4018 29320006
Ear disorder 12.51 10.48 31 250472 1243 29322781
Monoparesis 12.48 10.48 40 250463 1863 29322161
Ventricular hyperkinesia 12.45 10.48 12 250491 203 29323821
Rectal tenesmus 12.43 10.48 21 250482 637 29323387
Liver disorder 12.39 10.48 163 250340 27586 29296438
Gastric haemorrhage 12.35 10.48 39 250464 9258 29314766
Lip ulceration 12.33 10.48 22 250481 698 29323326
Akinesia 12.30 10.48 41 250462 1949 29322075
Heart rate decreased 12.30 10.48 287 250216 24625 29299399
Hepatitis cholestatic 12.18 10.48 25 250478 6868 29317156
Injury 12.12 10.48 103 250400 18943 29305081
Drug-induced liver injury 12.09 10.48 121 250382 21534 29302490
Congenital central nervous system anomaly 12.08 10.48 17 250486 438 29323586
Cyst 12.08 10.48 66 250437 3911 29320113
Pectus excavatum 12.08 10.48 12 250491 211 29323813
Renal cyst haemorrhage 12.07 10.48 16 250487 389 29323635
Monocyte percentage increased 12.07 10.48 25 250478 888 29323136
Renal injury 12.06 10.48 45 250458 10157 29313867
Pruritus allergic 12.00 10.48 11 250492 174 29323850
Arthrodesis 12.00 10.48 17 250486 441 29323583
Middle ear effusion 11.98 10.48 19 250484 546 29323478
Blood pressure diastolic abnormal 11.92 10.48 48 250455 2503 29321521
Weight gain poor 11.92 10.48 24 250479 835 29323189
Acne 11.90 10.48 125 250378 9095 29314929
Congenital bladder anomaly 11.76 10.48 13 250490 260 29323764
Epstein-Barr virus infection 11.75 10.48 24 250479 6605 29317419
Accessory spleen 11.73 10.48 10 250493 143 29323881
Drug screen positive 11.73 10.48 9 250494 3792 29320232
Limb reduction defect 11.72 10.48 13 250490 261 29323763
Hypersomnia 11.70 10.48 141 250362 10613 29313411
Congenital anomaly 11.68 10.48 31 250472 1297 29322727
Heparin-induced thrombocytopenia 11.67 10.48 15 250488 4964 29319060
Soft tissue mass 11.62 10.48 20 250483 616 29323408
Bronchitis 11.57 10.48 401 250102 36467 29287557
Obsessive-compulsive disorder 11.56 10.48 13 250490 4563 29319461
Gastrooesophageal reflux disease 11.55 10.48 349 250154 31147 29292877
Macrocephaly 11.53 10.48 16 250487 407 29323617
Fibula fracture 11.52 10.48 22 250481 736 29323288
Hyperparathyroidism 11.51 10.48 28 250475 1109 29322915
Aortic valve stenosis 11.50 10.48 43 250460 2165 29321859
Cleft lip 11.49 10.48 14 250489 312 29323712
C-reactive protein decreased 11.47 10.48 34 250469 1517 29322507
Hepatitis B 11.46 10.48 18 250485 5479 29318545
Bronchiolitis 11.44 10.48 50 250453 2705 29321319
Retinitis viral 11.41 10.48 8 250495 84 29323940
Euglycaemic diabetic ketoacidosis 11.41 10.48 4 250499 2626 29321398
Blood parathyroid hormone decreased 11.41 10.48 23 250480 801 29323223
Trismus 11.39 10.48 3 250500 2370 29321654
Drug intolerance 11.38 10.48 510 249993 47869 29276155
Ceruloplasmin decreased 11.34 10.48 3 250500 0 29324024
Hypnopompic hallucination 11.34 10.48 3 250500 0 29324024
Menopausal symptoms 11.34 10.48 3 250500 0 29324024
Alcohol abuse 11.29 10.48 12 250491 4321 29319703
Asthenia 11.29 10.48 2029 248474 213221 29110803
Cervical radiculopathy 11.28 10.48 14 250489 318 29323706
Seasonal allergy 11.28 10.48 78 250425 5024 29319000
Arthropod bite 11.26 10.48 45 250458 2338 29321686
Knee arthroplasty 11.23 10.48 86 250417 5723 29318301
Psychomotor hyperactivity 11.23 10.48 34 250469 8179 29315845
Anhedonia 11.19 10.48 28 250475 7172 29316852
Hyperhidrosis 11.18 10.48 440 250063 64100 29259924
Post-traumatic headache 11.15 10.48 7 250496 60 29323964
Ileal stenosis 11.12 10.48 29 250474 1200 29322824
Hepatic cyst 11.07 10.48 44 250459 2281 29321743
Gait disturbance 11.06 10.48 742 249761 72607 29251417
Haematocrit decreased 11.03 10.48 323 250180 28699 29295325
Exposure to toxic agent 11.03 10.48 4 250499 2571 29321453
Product complaint 10.98 10.48 18 250485 5387 29318637
Spinal operation 10.95 10.48 45 250458 2369 29321655
White blood cells urine positive 10.93 10.48 28 250475 1146 29322878
Haemangioma congenital 10.89 10.48 17 250486 482 29323542
Intestinal stenosis 10.88 10.48 38 250465 1850 29322174
Drug ineffective for unapproved indication 10.88 10.48 73 250430 14141 29309883
Oropharyngeal pain 10.88 10.48 325 250178 28960 29295064
Ankyloglossia congenital 10.87 10.48 13 250490 284 29323740
Hepatic haematoma 10.85 10.48 15 250488 380 29323644
Atypical fibroxanthoma 10.82 10.48 11 250492 199 29323825
Hepatitis B reactivation 10.81 10.48 7 250496 3222 29320802
Hyperglycaemia 10.78 10.48 215 250288 34072 29289952
Hand deformity 10.70 10.48 41 250462 2089 29321935
Drug use disorder 10.69 10.48 8 250495 3414 29320610
Congenital foot malformation 10.68 10.48 15 250488 386 29323638
Limb discomfort 10.65 10.48 126 250377 9442 29314582
Tonsil cancer 10.60 10.48 24 250479 907 29323117
Stoma complication 10.56 10.48 11 250492 205 29323819
Eosinophil percentage increased 10.56 10.48 17 250486 495 29323529
Spinal pain 10.54 10.48 74 250429 4790 29319234
Sinus operation 10.54 10.48 18 250485 551 29323473
Loss of consciousness 10.54 10.48 516 249987 73540 29250484
Hepatocellular injury 10.54 10.48 122 250381 21121 29302903
Device loosening 10.53 10.48 8 250495 96 29323928
Pneumonia aspiration 10.49 10.48 234 250269 36503 29287521
Haemorrhage intracranial 10.48 10.48 76 250427 14466 29309558
Caesarean section 10.48 10.48 38 250465 1885 29322139

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 1619.71 10.60 230 685004 224184 63589314
Toxicity to various agents 1564.85 10.60 965 684269 362548 63450950
Drug abuse 960.86 10.60 133 685101 132241 63681257
Rheumatoid arthritis 627.88 10.60 3420 681814 160874 63652624
Drug interaction 566.42 10.60 1962 683272 360121 63453377
Intentional overdose 502.98 10.60 164 685070 89780 63723718
Arthralgia 456.66 10.60 6908 678326 435352 63378146
Overdose 416.25 10.60 657 684577 158909 63654589
Arthropathy 377.60 10.60 2388 682846 118579 63694919
Death 370.63 10.60 3312 681922 479393 63334105
Joint swelling 356.72 10.60 3677 681557 211705 63601793
Cardiac arrest 351.41 10.60 690 684544 153374 63660124
Pain 336.94 10.60 7970 677264 545541 63267957
Fatigue 324.35 10.60 10316 674918 738414 63075084
Pemphigus 315.14 10.60 1380 683854 59321 63754177
Systemic lupus erythematosus 304.50 10.60 1628 683606 75984 63737514
Alopecia 302.04 10.60 2886 682348 162804 63650694
Glossodynia 287.97 10.60 1406 683828 63290 63750208
Hand deformity 283.58 10.60 1370 683864 61401 63752097
Hepatic function abnormal 276.97 10.60 170 685064 64143 63749355
Suicide attempt 276.05 10.60 210 685024 70797 63742701
Wound 267.94 10.60 1556 683678 74921 63738577
Maternal exposure during pregnancy 267.10 10.60 1840 683394 94044 63719454
Acute kidney injury 262.61 10.60 3284 681950 445956 63367542
Depressed level of consciousness 260.63 10.60 288 684946 81148 63732350
Respiratory arrest 256.04 10.60 121 685113 52864 63760634
Nasopharyngitis 247.09 10.60 3175 682059 192898 63620600
Abdominal discomfort 245.88 10.60 2990 682244 179332 63634166
Febrile neutropenia 243.11 10.60 1095 684139 186562 63626936
Cardio-respiratory arrest 242.64 10.60 420 684814 97973 63715525
Synovitis 227.33 10.60 1816 683418 97274 63716224
Femur fracture 214.27 10.60 823 684411 33312 63780186
Multiple organ dysfunction syndrome 207.16 10.60 483 684751 100930 63712568
Sinusitis 204.95 10.60 2412 682822 143516 63669982
Anti-cyclic citrullinated peptide antibody positive 203.54 10.60 1053 684181 48509 63764989
Peripheral swelling 197.99 10.60 3222 682012 205931 63607567
Coma 197.44 10.60 395 684839 87220 63726278
Renal failure 194.08 10.60 1133 684101 180555 63632943
Pericarditis 189.91 10.60 1226 684008 61290 63752208
Drug reaction with eosinophilia and systemic symptoms 187.92 10.60 179 685055 54038 63759460
Psoriasis 185.66 10.60 1352 683882 70351 63743147
Drug resistance 180.93 10.60 73 685161 35029 63778469
Infusion related reaction 180.38 10.60 2598 682636 161869 63651629
Hypotension 179.29 10.60 2907 682327 378067 63435431
Osteoarthritis 173.72 10.60 1211 684023 62125 63751373
Rhabdomyolysis 172.39 10.60 456 684778 91270 63722228
Serotonin syndrome 167.51 10.60 105 685129 39177 63774321
Fall 164.65 10.60 5685 679549 411141 63402357
Musculoskeletal stiffness 160.56 10.60 2008 683226 121198 63692300
Cytomegalovirus infection 157.84 10.60 100 685134 37099 63776399
Lactic acidosis 157.04 10.60 256 684978 61154 63752344
Psoriatic arthropathy 153.10 10.60 883 684351 42398 63771100
Sedation 150.70 10.60 131 685103 41331 63772167
Cardiac failure 145.87 10.60 817 684417 131556 63681942
Pain in extremity 145.61 10.60 4233 681001 298852 63514646
Malignant neoplasm progression 144.06 10.60 662 684572 112209 63701289
Impaired healing 140.67 10.60 1112 684122 59361 63754137
Hepatic failure 139.71 10.60 233 685001 55161 63758337
Infective pulmonary exacerbation of cystic fibrosis 137.92 10.60 353 684881 11443 63802055
Disseminated intravascular coagulation 131.79 10.60 91 685143 32257 63781241
Drug hypersensitivity 131.76 10.60 1757 683477 236058 63577440
Shock 129.33 10.60 129 685105 38111 63775387
Poisoning 129.33 10.60 36 685198 21843 63791655
Discomfort 128.56 10.60 1370 683864 79508 63733990
Swelling 127.09 10.60 2400 682834 157818 63655680
Multiple sclerosis relapse 125.09 10.60 807 684427 40328 63773170
Myocardial infarction 122.76 10.60 1147 684087 164674 63648824
Agitation 122.07 10.60 503 684731 87864 63725634
Neutropenia 119.45 10.60 1808 683426 237816 63575682
Product dose omission issue 115.33 10.60 2796 682438 191951 63621547
Product use in unapproved indication 114.49 10.60 1261 683973 175357 63638141
Metabolic acidosis 113.65 10.60 380 684854 70578 63742920
Bradycardia 112.36 10.60 764 684470 117455 63696043
Respiratory failure 112.10 10.60 1132 684102 160051 63653447
Rheumatoid factor positive 111.55 10.60 694 684540 34244 63779254
Duodenal ulcer perforation 108.81 10.60 685 684549 33940 63779558
Therapeutic product effect decreased 108.65 10.60 1776 683458 113575 63699923
Exposure during pregnancy 108.57 10.60 1283 683951 76392 63737106
Helicobacter infection 108.43 10.60 739 684495 37623 63775875
Altered state of consciousness 107.59 10.60 147 685087 37755 63775743
Electrocardiogram QT prolonged 104.95 10.60 460 684774 78988 63734510
Weight increased 104.91 10.60 2989 682245 210359 63603139
Thrombocytopenia 103.67 10.60 1712 683522 222089 63591409
Mydriasis 102.89 10.60 19 685215 15293 63798205
Intentional self-injury 102.87 10.60 94 685140 28950 63784548
Poisoning deliberate 98.82 10.60 13 685221 13445 63800053
Vitamin D deficiency 98.67 10.60 311 684923 11381 63802117
Arthritis 95.82 10.60 1334 683900 82480 63731018
Osteoporosis 95.79 10.60 770 684464 41310 63772188
Product use issue 94.62 10.60 2194 683040 149521 63663977
Lower respiratory tract infection 94.46 10.60 1471 683763 93143 63720355
Sickle cell anaemia with crisis 92.99 10.60 187 685047 5145 63808353
Blood creatine phosphokinase increased 92.81 10.60 315 684919 58243 63755255
Tooth disorder 92.68 10.60 477 684757 21925 63791573
Contraindicated product administered 92.38 10.60 1635 683599 106194 63707304
Neuroleptic malignant syndrome 92.02 10.60 78 685156 24918 63788580
Hyperkalaemia 86.71 10.60 673 684561 100456 63713042
Urinary tract infection 86.32 10.60 3139 682095 228457 63585041
Blood pressure fluctuation 83.51 10.60 881 684353 50990 63762508
Musculoskeletal pain 83.10 10.60 1269 683965 80025 63733473
Low turnover osteopathy 82.97 10.60 101 685133 1772 63811726
Red blood cell sedimentation rate abnormal 82.53 10.60 368 684866 15938 63797560
Intentional product misuse 82.46 10.60 441 684793 71854 63741644
Abortion spontaneous 81.24 10.60 501 684733 24642 63788856
Hepatic enzyme increased 80.96 10.60 1879 683355 128064 63685434
Foot fracture 80.32 10.60 394 684840 17763 63795735
Ventricular tachycardia 80.19 10.60 151 685083 34114 63779384
Knee arthroplasty 79.84 10.60 526 684708 26473 63787025
Hip arthroplasty 79.72 10.60 442 684792 20909 63792589
Acute hepatic failure 79.57 10.60 96 685138 26016 63787482
Brain oedema 78.71 10.60 71 685163 22004 63791494
Renal impairment 78.21 10.60 988 684246 134029 63679469
Hypoglycaemia 77.16 10.60 598 684636 89294 63724204
Contusion 76.66 10.60 1666 683568 112299 63701199
Somnolence 76.51 10.60 1615 683619 202030 63611468
Tooth fracture 76.50 10.60 256 684978 9671 63803827
Injection site pruritus 75.94 10.60 673 684561 37153 63776345
Acute respiratory distress syndrome 75.87 10.60 190 685044 38745 63774753
Post transplant lymphoproliferative disorder 75.69 10.60 7 685227 9537 63803961
Injection site reaction 75.32 10.60 793 684441 45871 63767627
Septic shock 74.73 10.60 737 684497 104700 63708798
Ventricular fibrillation 74.55 10.60 86 685148 23774 63789724
Interstitial lung disease 74.03 10.60 672 684562 97060 63716438
Tachycardia 73.65 10.60 1131 684103 148448 63665050
C-reactive protein abnormal 73.61 10.60 545 684689 28502 63784996
Back pain 72.08 10.60 3299 681935 246872 63566626
Toxic epidermal necrolysis 71.93 10.60 182 685052 36984 63776514
Bone giant cell tumour 71.48 10.60 26 685208 33 63813465
Torsade de pointes 70.52 10.60 49 685185 17314 63796184
Neurotoxicity 70.28 10.60 114 685120 27290 63786208
Drug dependence 70.14 10.60 156 685078 33156 63780342
Anaphylactic reaction 69.66 10.60 435 684799 68229 63745269
Cardiac failure congestive 69.27 10.60 973 684261 129607 63683891
Mental status changes 69.25 10.60 374 684860 60788 63752710
Injection site erythema 68.85 10.60 1096 684138 69704 63743794
Juvenile idiopathic arthritis 68.79 10.60 137 685097 3742 63809756
Substance abuse 68.17 10.60 9 685225 9283 63804215
Vitamin D decreased 68.14 10.60 208 685026 7479 63806019
Fracture 67.87 10.60 385 684849 18370 63795128
Spinal fracture 67.64 10.60 330 684904 14844 63798654
Cardiogenic shock 67.35 10.60 153 685081 32274 63781224
Device expulsion 66.23 10.60 76 685158 21060 63792438
Joint effusion 65.89 10.60 301 684933 13172 63800326
Basal cell carcinoma 65.73 10.60 556 684678 30282 63783216
Posterior reversible encephalopathy syndrome 65.12 10.60 89 685145 22857 63790641
Myoclonus 64.87 10.60 104 685130 25014 63788484
Pathogen resistance 64.78 10.60 26 685208 12517 63800981
Hepatotoxicity 64.67 10.60 213 685021 39749 63773749
Disease progression 63.86 10.60 1089 684145 140591 63672907
Acute graft versus host disease 63.84 10.60 10 685224 9074 63804424
Delirium 63.83 10.60 451 684783 68743 63744755
Unresponsive to stimuli 63.41 10.60 297 684937 50096 63763402
Drug withdrawal syndrome 63.09 10.60 150 685084 31141 63782357
Anaphylactic shock 63.06 10.60 143 685091 30185 63783313
Miosis 63.00 10.60 31 685203 13235 63800263
Sopor 62.37 10.60 139 685095 29522 63783976
Mucormycosis 62.11 10.60 4 685230 7337 63806161
Venoocclusive liver disease 62.02 10.60 15 685219 10000 63803498
Coronary artery disease 61.74 10.60 382 684852 60051 63753447
Haematotoxicity 61.45 10.60 30 685204 12866 63800632
Coagulopathy 61.24 10.60 157 685077 31763 63781735
Respiratory depression 60.61 10.60 97 685137 23346 63790152
Extrapyramidal disorder 60.52 10.60 71 685163 19481 63794017
Status epilepticus 60.50 10.60 85 685149 21578 63791920
Emotional distress 60.47 10.60 189 685045 35849 63777649
Encephalopathy 59.99 10.60 372 684862 58447 63755051
Cerebral infarction 59.60 10.60 229 685005 40815 63772683
Spinal osteoarthritis 59.07 10.60 305 684929 14036 63799462
Palmar-plantar erythrodysaesthesia syndrome 59.02 10.60 137 685097 28682 63784816
Fracture delayed union 58.81 10.60 88 685146 1897 63811601
Stevens-Johnson syndrome 58.62 10.60 178 685056 34071 63779427
Foot deformity 58.54 10.60 337 684897 16167 63797331
Angioedema 58.48 10.60 400 684834 61421 63752077
Influenza 57.82 10.60 1512 683722 105019 63708479
Drug intolerance 57.40 10.60 2494 682740 185498 63628000
Headache 57.27 10.60 6443 678791 523024 63290474
Pregnancy 57.21 10.60 399 684835 20466 63793032
Muscle injury 56.53 10.60 477 684757 25960 63787538
Bronchopulmonary aspergillosis 56.23 10.60 72 685162 19013 63794485
Irritable bowel syndrome 56.12 10.60 626 684608 36743 63776755
Injection site swelling 55.12 10.60 677 684557 40676 63772822
Aggression 54.97 10.60 278 684956 45954 63767544
Weight decreased 54.97 10.60 3630 681604 282109 63531389
Ejection fraction decreased 54.45 10.60 142 685092 28565 63784933
Psychotic disorder 54.11 10.60 187 685047 34391 63779107
Dystonia 53.71 10.60 73 685161 18792 63794706
Hyponatraemia 53.49 10.60 1184 684050 147155 63666343
Cerebral haemorrhage 53.21 10.60 321 684913 50769 63762729
Oropharyngeal pain 53.18 10.60 1278 683956 87589 63725909
Thrombotic microangiopathy 53.15 10.60 59 685175 16596 63796902
Bone density decreased 52.95 10.60 228 685006 9724 63803774
Drug level increased 52.80 10.60 186 685048 34010 63779488
Intervertebral disc degeneration 51.95 10.60 276 684958 12844 63800654
Muscle spasticity 51.89 10.60 329 684905 16340 63797158
Aspergillus infection 51.21 10.60 59 685175 16320 63797178
Bone disorder 51.07 10.60 329 684905 16430 63797068
Sedation complication 51.01 10.60 23 685211 10331 63803167
Graft versus host disease 50.97 10.60 43 685191 13770 63799728
Sleep disorder due to general medical condition, insomnia type 50.48 10.60 463 684771 25807 63787691
Pulmonary oedema 50.42 10.60 563 684671 78111 63735387
Localised infection 50.30 10.60 516 684718 29645 63783853
Injection site pain 50.12 10.60 1544 683690 109864 63703634
Myelosuppression 49.84 10.60 112 685122 23718 63789780
Osteopenia 49.80 10.60 309 684925 15231 63798267
Seizure 49.60 10.60 1371 683863 165521 63647977
Asphyxia 49.12 10.60 20 685214 9546 63803952
Thoracic vertebral fracture 48.89 10.60 132 685102 4421 63809077
Gastrointestinal haemorrhage 48.58 10.60 1053 684181 131259 63682239
Bronchitis 47.84 10.60 1503 683731 107240 63706258
Graft versus host disease in gastrointestinal tract 47.66 10.60 3 685231 5609 63807889
Blood bilirubin increased 47.47 10.60 387 684847 57166 63756332
Folliculitis 47.08 10.60 508 684726 29569 63783929
International normalised ratio increased 47.07 10.60 576 684658 78591 63734907
Anhedonia 46.61 10.60 46 685188 13660 63799838
Hyperhidrosis 46.20 10.60 993 684241 123927 63689571
Rash maculo-papular 46.11 10.60 301 684933 46725 63766773
Bone marrow failure 45.98 10.60 309 684925 47643 63765855
Transplant rejection 45.93 10.60 71 685163 17330 63796168
Haemodialysis 45.73 10.60 69 685165 17008 63796490
Hyperthermia 45.46 10.60 59 685175 15491 63798007
Ascites 45.35 10.60 430 684804 61571 63751927
Hypoxia 44.92 10.60 662 684572 87487 63726011
Akathisia 44.77 10.60 34 685200 11476 63802022
Sepsis 44.56 10.60 1996 683238 228345 63585153
Synovial cyst 44.47 10.60 181 685053 7526 63805972
Multiple sclerosis 44.41 10.60 349 684885 18592 63794906
Angina pectoris 43.98 10.60 289 684945 44792 63768706
Cataract 43.77 10.60 777 684457 50485 63763013
Night sweats 43.75 10.60 580 684654 35466 63778032
Acute generalised exanthematous pustulosis 43.56 10.60 51 685183 14007 63799491
Disability assessment scale score increased 43.25 10.60 88 685146 2442 63811056
Hepatocellular injury 43.12 10.60 292 684942 44943 63768555
Respiratory distress 43.11 10.60 352 684882 51979 63761519
Bone loss 42.99 10.60 80 685154 2075 63811423
Acute graft versus host disease in skin 42.98 10.60 10 685224 6845 63806653
Enthesopathy 42.53 10.60 209 685025 9429 63804069
Loss of consciousness 42.50 10.60 1225 684009 147140 63666358
Gait disturbance 42.38 10.60 2236 682998 169919 63643579
Joint injury 42.37 10.60 401 684833 22546 63790952
Suicidal ideation 42.31 10.60 477 684757 66065 63747433
Hypersensitivity 42.03 10.60 2519 682715 193933 63619565
Colitis ulcerative 41.82 10.60 401 684833 22627 63790871
Tumour lysis syndrome 41.78 10.60 90 685144 19350 63794148
Cyanosis 41.71 10.60 110 685124 22045 63791453
Body height decreased 41.69 10.60 175 685059 7379 63806119
Eosinophilia 41.37 10.60 236 684998 37840 63775658
Dry eye 41.27 10.60 481 684753 28538 63784960
Hypoaesthesia 41.22 10.60 1840 683394 137268 63676230
Ear pain 40.95 10.60 428 684806 24708 63788790
Stress fracture 40.68 10.60 142 685092 5482 63808016
Pyrexia 40.63 10.60 5257 679977 553387 63260111
Dental caries 40.60 10.60 224 685010 10576 63802922
Anuria 40.59 10.60 88 685146 18876 63794622
Pleural effusion 40.40 10.60 1029 684205 125530 63687968
Gestational diabetes 40.31 10.60 141 685093 5449 63808049
Blood creatinine increased 40.19 10.60 1116 684118 134666 63678832
Toxic skin eruption 40.03 10.60 91 685143 19193 63794305
Creatinine renal clearance decreased 39.86 10.60 57 685177 14364 63799134
Ear infection 39.79 10.60 402 684832 23002 63790496
Chronic graft versus host disease 39.66 10.60 9 685225 6267 63807231
Bone density abnormal 39.47 10.60 89 685145 2656 63810842
Accidental overdose 39.21 10.60 203 685031 33354 63780144
Febrile bone marrow aplasia 39.18 10.60 37 685197 11218 63802280
Nephrolithiasis 39.05 10.60 667 684567 43016 63770482
Joint stiffness 38.91 10.60 494 684740 29910 63783588
Gastrooesophageal reflux disease 38.65 10.60 1157 684077 81986 63731512
Neutrophil count decreased 38.55 10.60 582 684652 76614 63736884
Injection site bruising 38.40 10.60 571 684663 35802 63777696
Exostosis 38.27 10.60 230 685004 11208 63802290
Tendonitis 38.23 10.60 356 684878 19926 63793572
Unintentional medical device removal 38.12 10.60 12 685222 6722 63806776
Red blood cell count decreased 38.03 10.60 724 684510 47662 63765836
Breast cancer 37.90 10.60 475 684759 28673 63784825
Exposure via ingestion 37.82 10.60 4 685230 4898 63808600
Drug ineffective for unapproved indication 37.70 10.60 186 685048 30947 63782551
Melaena 37.63 10.60 375 684859 53173 63760325
Fibromyalgia 37.36 10.60 560 684674 35171 63778327
Inappropriate antidiuretic hormone secretion 37.32 10.60 117 685117 22172 63791326
Wrist fracture 37.31 10.60 207 685027 9794 63803704
Acute myeloid leukaemia 36.87 10.60 158 685076 27305 63786193
Red blood cell sedimentation rate increased 36.84 10.60 500 684734 30735 63782763
Cardiotoxicity 36.68 10.60 33 685201 10241 63803257
Pulmonary alveolar haemorrhage 36.32 10.60 30 685204 9708 63803790
Toothache 36.27 10.60 313 684921 17146 63796352
Polyarthritis 36.19 10.60 201 685033 9514 63803984
Epstein-Barr virus infection 35.88 10.60 48 685186 12440 63801058
Syncope 35.79 10.60 1341 683893 156294 63657204
Sinus tachycardia 35.79 10.60 198 685036 31990 63781508
Grip strength decreased 35.63 10.60 230 685004 11494 63802004
Hypokalaemia 35.55 10.60 1004 684230 120899 63692599
Joint laxity 35.50 10.60 77 685157 2237 63811261
Cystitis 35.43 10.60 644 684590 42031 63771467
Caesarean section 35.39 10.60 223 685011 11051 63802447
Cough 35.38 10.60 3697 681537 298451 63515047
Hyperglycaemia 35.33 10.60 446 684788 60522 63752976
Endophthalmitis 35.32 10.60 7 685227 5358 63808140
Blood cholesterol increased 35.29 10.60 737 684497 49329 63764169
Atypical femur fracture 35.18 10.60 120 685114 4578 63808920
Hypothermia 34.84 10.60 102 685132 19754 63793744
Upper respiratory tract infection 34.68 10.60 1016 684218 71769 63741729
Hypercalcaemia 34.67 10.60 497 684737 30919 63782579
Haemodynamic instability 34.64 10.60 66 685168 14846 63798652
Skin cancer 34.63 10.60 232 685002 11742 63801756
Aspartate aminotransferase increased 34.57 10.60 988 684246 118800 63694698
Platelet count decreased 34.55 10.60 1443 683791 166268 63647230
Malignant melanoma 34.43 10.60 246 684988 12718 63800780
Scoliosis 34.43 10.60 142 685092 5940 63807558
Orthostatic hypotension 34.24 10.60 324 684910 46414 63767084
Live birth 34.17 10.60 220 685014 10984 63802514
Nocardiosis 34.07 10.60 5 685229 4762 63808736
Restlessness 33.97 10.60 265 684969 39520 63773978
Laryngitis 33.89 10.60 217 685017 10814 63802684
Agranulocytosis 33.89 10.60 252 684982 37977 63775521
Electrocardiogram QRS complex prolonged 33.84 10.60 29 685205 9215 63804283
Oral herpes 33.68 10.60 372 684862 21780 63791718
Drug abuser 33.51 10.60 10 685224 5798 63807700
Wrong technique in product usage process 33.43 10.60 487 684747 64487 63749011
Accidental exposure to product 33.39 10.60 155 685079 26209 63787289
Multiple fractures 33.39 10.60 140 685094 5900 63807598
Blood pressure diastolic abnormal 33.33 10.60 229 685005 11688 63801810
Anaemia 33.31 10.60 3518 681716 375162 63438336
Injection site rash 33.11 10.60 283 684951 15459 63798039
Gait spastic 33.03 10.60 44 685190 848 63812650
Second primary malignancy 32.89 10.60 50 685184 12287 63801211
Immune reconstitution inflammatory syndrome 32.80 10.60 51 685183 12419 63801079
Proteinuria 32.79 10.60 167 685067 27556 63785942
Renal injury 32.69 10.60 72 685162 15357 63798141
Gastroenteritis viral 32.65 10.60 337 684897 19392 63794106
Acute myocardial infarction 32.33 10.60 533 684701 69185 63744313
Increased tendency to bruise 32.19 10.60 188 685046 9067 63804431
Nephropathy toxic 32.18 10.60 88 685146 17426 63796072
Toxic encephalopathy 32.18 10.60 34 685200 9781 63803717
Acute coronary syndrome 31.88 10.60 102 685132 19208 63794290
Spinal stenosis 31.74 10.60 255 684979 13676 63799822
Pulseless electrical activity 31.73 10.60 54 685180 12685 63800813
Bronchospasm 31.46 10.60 121 685113 21561 63791937
Exposure to toxic agent 31.43 10.60 13 685221 6146 63807352
Infection 31.38 10.60 2325 682909 182555 63630943
Vomiting 31.36 10.60 5262 679972 545855 63267643
Arrhythmia 31.17 10.60 386 684848 52558 63760940
Device use error 30.91 10.60 15 685219 6456 63807042
Polyomavirus-associated nephropathy 30.90 10.60 7 685227 4881 63808617
Memory impairment 30.81 10.60 1157 684077 84525 63728973
Blood pressure systolic abnormal 30.80 10.60 196 685038 9746 63803752
Blood alkaline phosphatase increased 30.67 10.60 417 684817 55862 63757636
Cyst 30.66 10.60 226 685008 11801 63801697
Pulmonary embolism 30.62 10.60 1257 683977 145099 63668399
Hyperammonaemia 30.61 10.60 36 685198 9868 63803630
Blister 30.49 10.60 1099 684135 79868 63733630
Hallucination, auditory 30.47 10.60 86 685148 16853 63796645
Hyperbilirubinaemia 30.34 10.60 119 685115 21086 63792412
Jaundice 29.96 10.60 350 684884 48162 63765336
Drug-induced liver injury 29.71 10.60 343 684891 47300 63766198
Fear 29.63 10.60 112 685122 20059 63793439
Cholestasis 29.58 10.60 319 684915 44553 63768945
Paradoxical drug reaction 29.52 10.60 14 685220 6106 63807392
Drug screen positive 29.38 10.60 12 685222 5717 63807781
Face oedema 29.37 10.60 149 685085 24612 63788886
Disorientation 29.23 10.60 417 684817 55411 63758087
Muscle rigidity 29.06 10.60 92 685142 17381 63796117
Ill-defined disorder 28.97 10.60 642 684592 43410 63770088
Heart rate decreased 28.84 10.60 778 684456 54289 63759209
Blood pressure increased 28.78 10.60 2167 683067 170385 63643113
Myopathy 28.77 10.60 94 685140 17586 63795912
Fracture nonunion 28.72 10.60 54 685180 1412 63812086
BK virus infection 28.69 10.60 22 685212 7390 63806108
Condition aggravated 28.68 10.60 4441 680793 367985 63445513
Surgery 28.66 10.60 440 684794 27773 63785725
Folate deficiency 28.57 10.60 79 685155 2684 63810814
Lumbar vertebral fracture 28.47 10.60 125 685109 5377 63808121
Pancreatitis 28.20 10.60 454 684780 59153 63754345
Loss of personal independence in daily activities 28.16 10.60 987 684247 71467 63742031
Mouth ulceration 28.14 10.60 493 684741 31951 63781547
Product quality issue 28.08 10.60 193 685041 29606 63783892
Rheumatic fever 28.04 10.60 182 685052 9112 63804386
Herpes zoster 27.92 10.60 1067 684167 78120 63735378
Cystitis haemorrhagic 27.87 10.60 26 685208 7930 63805568
Abnormal behaviour 27.76 10.60 226 685008 33396 63780102
Ileus paralytic 27.75 10.60 29 685205 8386 63805112
Haemophagocytic lymphohistiocytosis 27.71 10.60 95 685139 17514 63795984
Latent tuberculosis 27.69 10.60 78 685156 2679 63810819
Full blood count decreased 27.67 10.60 364 684870 22218 63791280
Nodule 27.56 10.60 302 684932 17645 63795853
Muscle spasms 27.51 10.60 1794 683440 139229 63674269
Rhinorrhoea 27.46 10.60 833 684401 59136 63754362
Alanine aminotransferase increased 27.42 10.60 1202 684032 137829 63675669
Cytomegalovirus chorioretinitis 27.37 10.60 9 685225 4903 63808595
Pneumothorax 27.27 10.60 149 685085 24149 63789349
Burning sensation 27.26 10.60 706 684528 48958 63764540
Maternal exposure before pregnancy 27.00 10.60 90 685144 3393 63810105
Leukopenia 26.98 10.60 844 684390 100398 63713100
Carpal tunnel syndrome 26.97 10.60 272 684962 15556 63797942
Myocardial ischaemia 26.97 10.60 141 685093 23110 63790388
Limb discomfort 26.91 10.60 422 684812 26753 63786745
Mania 26.91 10.60 86 685148 16200 63797298
Cytomegalovirus viraemia 26.88 10.60 46 685188 10782 63802716
Multiple-drug resistance 26.87 10.60 18 685216 6484 63807014
Metastases to liver 26.76 10.60 147 685087 23794 63789704
Angina unstable 26.74 10.60 80 685154 15387 63798111
Venoocclusive disease 26.66 10.60 5 685229 3980 63809518
Tenosynovitis 26.63 10.60 216 685018 11617 63801881
Catatonia 26.58 10.60 25 685209 7595 63805903
Musculoskeletal discomfort 26.44 10.60 277 684957 16000 63797498
Ankle fracture 26.14 10.60 255 684979 14455 63799043
Drug use disorder 26.06 10.60 16 685218 6038 63807460
General physical health deterioration 26.02 10.60 2516 682718 201909 63611589
Blood lactic acid increased 25.99 10.60 44 685190 10357 63803141
Swollen joint count increased 25.97 10.60 155 685079 7534 63805964
Blood pressure diastolic decreased 25.89 10.60 356 684878 21945 63791553
Transplant dysfunction 25.85 10.60 20 685214 6688 63806810
Tongue disorder 25.85 10.60 218 685016 11862 63801636
Ileus 25.68 10.60 141 685093 22825 63790673
Psychomotor hyperactivity 25.53 10.60 74 685160 14377 63799121
Poor venous access 25.47 10.60 222 685012 12195 63801303
Sciatica 25.40 10.60 328 684906 19936 63793562
Blood parathyroid hormone increased 25.20 10.60 82 685152 3052 63810446
Neck deformity 25.17 10.60 56 685178 1656 63811842
Neck pain 25.11 10.60 843 684391 60690 63752808
Hepatitis fulminant 25.09 10.60 18 685216 6256 63807242
Heparin-induced thrombocytopenia 24.96 10.60 32 685202 8447 63805051
Gastrointestinal disorder 24.92 10.60 1179 684055 88530 63724968
Cytokine release syndrome 24.90 10.60 125 685109 20704 63792794
Hypoalbuminaemia 24.77 10.60 100 685134 17574 63795924
Inflammation 24.74 10.60 887 684347 64413 63749085
Smear cervix abnormal 24.67 10.60 68 685166 2306 63811192
Purpura 24.54 10.60 97 685137 17149 63796349
Tubulointerstitial nephritis 24.51 10.60 210 685024 30699 63782799
Abdominal pain upper 24.35 10.60 2168 683066 172862 63640636
Respiratory acidosis 24.34 10.60 42 685192 9813 63803685
Oral infection 24.32 10.60 108 685126 4669 63808829
Tremor 24.24 10.60 1307 683927 146923 63666575
Osteonecrosis of jaw 24.20 10.60 574 684660 39251 63774247
Gamma-glutamyltransferase increased 24.12 10.60 366 684868 48144 63765354
Hepatic cytolysis 24.05 10.60 73 685161 13976 63799522
No adverse event 24.03 10.60 191 685043 28370 63785128
Tibia fracture 23.94 10.60 107 685127 4638 63808860
Adenovirus infection 23.93 10.60 25 685209 7230 63806268
Enterocolitis 23.92 10.60 58 685176 11960 63801538
Pulmonary congestion 23.84 10.60 152 685082 23728 63789770
Disease recurrence 23.70 10.60 217 685017 31293 63782205
Pneumatosis intestinalis 23.67 10.60 13 685221 5216 63808282
Product complaint 23.55 10.60 58 685176 11896 63801602
Haemorrhage 23.52 10.60 652 684582 78699 63734799
Acidosis 23.51 10.60 103 685131 17692 63795806
Cystic fibrosis 23.38 10.60 85 685149 3349 63810149
Gingival recession 23.33 10.60 42 685192 1061 63812437
Rash 23.30 10.60 5354 679880 453195 63360303
Upper limb fracture 23.22 10.60 251 684983 14615 63798883
Hepatitis cholestatic 23.15 10.60 60 685174 12095 63801403
Rotator cuff syndrome 23.07 10.60 213 685021 11894 63801604
Cross sensitivity reaction 23.01 10.60 4 685230 3363 63810135
Alcohol interaction 22.93 10.60 9 685225 4392 63809106
Haemorrhage intracranial 22.85 10.60 154 685080 23730 63789768
Potentiating drug interaction 22.74 10.60 30 685204 7822 63805676
Mobility decreased 22.55 10.60 1122 684112 84718 63728780
Erythema multiforme 22.54 10.60 88 685146 15613 63797885
Jaw disorder 22.47 10.60 103 685131 4514 63808984
Frequent bowel movements 22.40 10.60 295 684939 18010 63795488
Tenderness 22.39 10.60 312 684922 19290 63794208
Abortion incomplete 22.37 10.60 3 685231 3058 63810440
Skin papilloma 22.37 10.60 112 685122 5091 63808407
Hepatitis B reactivation 22.36 10.60 12 685222 4877 63808621
Irritability 22.35 10.60 266 684968 36480 63777018
Humerus fracture 22.34 10.60 152 685082 7733 63805765
Cerebrovascular accident 22.33 10.60 1214 684020 136369 63677129
Joint noise 22.30 10.60 80 685154 3131 63810367
Accidental death 22.26 10.60 6 685228 3719 63809779
Pneumocystis jirovecii pneumonia 22.25 10.60 187 685047 27447 63786051
Migraine 22.21 10.60 845 684389 61832 63751666
Dermatitis exfoliative 22.19 10.60 48 685186 10304 63803194
Invasive ductal breast carcinoma 22.01 10.60 109 685125 4933 63808565
Blood pressure decreased 21.91 10.60 723 684511 85476 63728022
Injury 21.89 10.60 441 684793 55551 63757947
Appendicolith 21.87 10.60 5 685229 3464 63810034
Tooth abscess 21.86 10.60 234 685000 13592 63799906
Graft versus host disease in skin 21.83 10.60 15 685219 5332 63808166
Pulmonary haemorrhage 21.81 10.60 69 685165 13040 63800458
Cognitive disorder 21.80 10.60 433 684801 54654 63758844
Metastases to lung 21.62 10.60 86 685148 15178 63798320
Hepatic encephalopathy 21.59 10.60 133 685101 20933 63792565
Therapy partial responder 21.57 10.60 48 685186 10200 63803298
Dyspnoea 21.54 10.60 7072 678162 711602 63101896
Bradyphrenia 21.53 10.60 42 685192 9364 63804134
Joint destruction 21.46 10.60 86 685148 3550 63809948
Blood glucose increased 21.43 10.60 838 684396 97235 63716263
Intestinal stenosis 21.41 10.60 79 685155 3135 63810363
Hemiplegia 21.39 10.60 67 685167 12701 63800797
Paraesthesia 21.36 10.60 1683 683551 132839 63680659
Gingival disorder 21.29 10.60 81 685153 3263 63810235
Squamous cell carcinoma of skin 21.17 10.60 206 685028 11670 63801828
Spinal disorder 21.17 10.60 162 685072 8560 63804938
Gastric haemorrhage 21.03 10.60 73 685161 13408 63800090
Upper respiratory tract inflammation 20.95 10.60 7 685227 3775 63809723
Diffuse large B-cell lymphoma recurrent 20.93 10.60 4 685230 3142 63810356
Muscle strain 20.90 10.60 154 685080 8040 63805458
Rheumatoid nodule 20.89 10.60 216 685018 12435 63801063
Alanine aminotransferase abnormal 20.85 10.60 135 685099 6753 63806745
Intraductal proliferative breast lesion 20.77 10.60 60 685174 2091 63811407
Metabolic disorder 20.71 10.60 31 685203 7666 63805832
Coronary arterial stent insertion 20.66 10.60 18 685216 5674 63807824
Fibula fracture 20.66 10.60 76 685158 3012 63810486
Stress cardiomyopathy 20.61 10.60 42 685192 9215 63804283
Mean cell volume increased 20.56 10.60 107 685127 4939 63808559
Device difficult to use 20.53 10.60 46 685188 9752 63803746
Shock haemorrhagic 20.51 10.60 100 685134 16691 63796807
Human herpesvirus 6 infection 20.45 10.60 12 685222 4642 63808856
Blood pressure diastolic increased 20.40 10.60 189 685045 10563 63802935
Needle fatigue 20.25 10.60 28 685206 560 63812938
Bone pain 20.25 10.60 655 684579 46917 63766581
Limb deformity 20.24 10.60 80 685154 3281 63810217
Aphthous ulcer 20.20 10.60 218 685016 12688 63800810
Cardiac failure acute 20.16 10.60 97 685137 16247 63797251
Polyhydramnios 20.04 10.60 47 685187 1440 63812058
Pre-eclampsia 20.03 10.60 124 685110 6107 63807391
Limb injury 19.96 10.60 356 684878 23149 63790349
Virologic failure 19.94 10.60 6 685228 3460 63810038
Anaemia postoperative 19.92 10.60 52 685182 1706 63811792
Vitamin D increased 19.84 10.60 25 685209 455 63813043
Hip fracture 19.78 10.60 401 684833 26698 63786800
Spondylolisthesis 19.74 10.60 70 685164 2724 63810774
Thyroid mass 19.72 10.60 77 685157 3140 63810358
Leukocytosis 19.72 10.60 282 684952 37458 63776040
Prothrombin time prolonged 19.67 10.60 93 685141 15648 63797850
Joint dislocation 19.52 10.60 197 685037 11268 63802230
Neck mass 19.52 10.60 90 685144 3954 63809544
Pulmonary fibrosis 19.51 10.60 435 684799 29443 63784055
Relapsing-remitting multiple sclerosis 19.49 10.60 39 685195 1069 63812429
Normal newborn 19.47 10.60 114 685120 5503 63807995
Injection site urticaria 19.47 10.60 193 685041 10988 63802510
Acute graft versus host disease in intestine 19.44 10.60 7 685227 3602 63809896
Post procedural infection 19.39 10.60 171 685063 9426 63804072
Tooth loss 19.26 10.60 123 685111 6124 63807374
Hyperlactacidaemia 19.24 10.60 14 685220 4830 63808668
Acute lung injury 19.21 10.60 3 685231 2728 63810770
Cholecystitis chronic 19.14 10.60 44 685190 9243 63804255
Oedema 19.13 10.60 790 684444 91145 63722353
Dental implantation 18.83 10.60 23 685211 405 63813093
Blood pressure systolic increased 18.80 10.60 672 684562 48781 63764717
Ligament sprain 18.74 10.60 187 685047 10665 63802833
Cellulitis 18.72 10.60 1194 684040 92463 63721035
Meniscus injury 18.64 10.60 117 685117 5790 63807708
Hyperaesthesia teeth 18.62 10.60 47 685187 1510 63811988
Haematochezia 18.58 10.60 873 684361 65500 63747998
Drug eruption 18.53 10.60 271 684963 35865 63777633
Lower respiratory tract infection viral 18.49 10.60 35 685199 920 63812578
Sexual dysfunction 18.46 10.60 25 685209 6446 63807052
Arthritis infective 18.44 10.60 133 685101 6897 63806601
Nephrotic syndrome 18.39 10.60 47 685187 9520 63803978
Dermatitis acneiform 18.22 10.60 39 685195 8404 63805094
Blood calcium increased 18.20 10.60 154 685080 8388 63805110
Obstructive airways disorder 18.17 10.60 158 685076 23027 63790471
Bursitis 18.10 10.60 325 684909 21160 63792338
Hyperparathyroidism 18.09 10.60 69 685165 2783 63810715
Liver disorder 18.04 10.60 430 684804 52921 63760577
Withdrawal syndrome 18.01 10.60 161 685073 23331 63790167
Left ventricular dysfunction 17.92 10.60 106 685128 16848 63796650
Bradypnoea 17.91 10.60 17 685217 5142 63808356
Hypophosphatasia 17.90 10.60 9 685225 36 63813462
Persecutory delusion 17.88 10.60 11 685223 4147 63809351
Lumbar spinal stenosis 17.85 10.60 97 685137 4553 63808945
Premature rupture of membranes 17.83 10.60 83 685151 3661 63809837
Pneumonia aspiration 17.82 10.60 486 684748 58785 63754713
Transaminases increased 17.80 10.60 350 684884 44244 63769254
Pharyngitis streptococcal 17.80 10.60 155 685079 8513 63804985
Diabetic ketoacidosis 17.79 10.60 217 685017 29628 63783870
Clavicle fracture 17.77 10.60 83 685151 3666 63809832
Aplasia 17.76 10.60 29 685205 6924 63806574
Tooth infection 17.74 10.60 235 684999 14366 63799132
Back disorder 17.66 10.60 173 685061 9817 63803681
Groin pain 17.63 10.60 192 685042 11201 63802297
Tonsillar ulcer 17.60 10.60 22 685212 397 63813101
Intervertebral disc protrusion 17.57 10.60 307 684927 19884 63793614
Sudden death 17.56 10.60 133 685101 19963 63793535
Arthropod bite 17.54 10.60 127 685107 6594 63806904
Hallucination, visual 17.50 10.60 200 685034 27634 63785864
Blood urea increased 17.49 10.60 347 684887 43806 63769692
Visual acuity reduced 17.47 10.60 194 685040 26947 63786551
Hernia 17.45 10.60 220 685014 13298 63800200
Vasoplegia syndrome 17.42 10.60 4 685230 2763 63810735
Generalised tonic-clonic seizure 17.41 10.60 308 684926 39549 63773949
Dysarthria 17.38 10.60 489 684745 58917 63754581
Hepatitis B 17.37 10.60 35 685199 7710 63805788
Skin toxicity 17.37 10.60 27 685207 6575 63806923
Tenosynovitis stenosans 17.34 10.60 53 685181 1907 63811591
Off label use 17.34 10.60 7209 678025 625597 63187901
Osteoporotic fracture 17.31 10.60 80 685154 3518 63809980
Bone erosion 17.30 10.60 194 685040 11401 63802097
Renal tubular necrosis 17.18 10.60 151 685083 21959 63791539
Large intestinal stenosis 17.17 10.60 61 685173 2376 63811122
Edentulous 17.16 10.60 17 685217 234 63813264
Blood iron decreased 17.15 10.60 201 685033 11941 63801557
Anti-neutrophil cytoplasmic antibody positive vasculitis 17.04 10.60 5 685229 2931 63810567
Eye infection 17.04 10.60 162 685072 9119 63804379
Hypercalciuria 17.03 10.60 22 685212 411 63813087
Product prescribing error 16.98 10.60 493 684741 34776 63778722
Inflammatory bowel disease 16.98 10.60 94 685140 4444 63809054
Disability 16.97 10.60 201 685033 11971 63801527
Atrioventricular block complete 16.97 10.60 87 685147 14331 63799167
Wheelchair user 16.96 10.60 96 685138 4576 63808922
Tardive dyskinesia 16.95 10.60 46 685188 9132 63804366
Temperature regulation disorder 16.95 10.60 12 685222 4199 63809299
Influenza like illness 16.94 10.60 810 684424 60892 63752606
Metastases to central nervous system 16.91 10.60 83 685151 13829 63799669
Mitochondrial toxicity 16.86 10.60 4 685230 2702 63810796
Bladder hypertrophy 16.70 10.60 25 685209 539 63812959
Spinal operation 16.65 10.60 117 685117 6016 63807482
Granulocytopenia 16.65 10.60 56 685178 10384 63803114
Oral pain 16.62 10.60 396 684838 27097 63786401
Lethargy 16.59 10.60 617 684617 71977 63741521
Musculoskeletal disorder 16.58 10.60 275 684959 17631 63795867
Oliguria 16.57 10.60 89 685145 14487 63799011
Aortic valve stenosis 16.56 10.60 94 685140 4486 63809012
Complications of transplanted kidney 16.54 10.60 20 685214 5415 63808083
Hypertonic bladder 16.45 10.60 76 685158 3342 63810156
Milk-alkali syndrome 16.40 10.60 38 685196 1155 63812343
Nasal congestion 16.34 10.60 783 684451 58875 63754623
Fungaemia 16.30 10.60 10 685224 3775 63809723
Ketoacidosis 16.27 10.60 30 685204 6833 63806665
Medication error 16.27 10.60 405 684829 49561 63763937
Endodontic procedure 16.24 10.60 58 685176 2265 63811233
Immunodeficiency 16.20 10.60 251 684983 15873 63797625
Peripheral sensory neuropathy 16.18 10.60 64 685170 11314 63802184
Periodontal disease 16.17 10.60 47 685187 1644 63811854
Hypoglycaemic coma 16.15 10.60 13 685221 4261 63809237
Injection site warmth 16.08 10.60 216 685018 13246 63800252
Pemphigoid 16.06 10.60 77 685157 12909 63800589
Coronary artery bypass 16.05 10.60 23 685211 5792 63807706
Diverticulum intestinal 15.93 10.60 134 685100 7286 63806212
Paranoia 15.86 10.60 105 685129 16247 63797251
Ventricular hypokinesia 15.85 10.60 37 685197 7732 63805766
Hyperprolactinaemia 15.82 10.60 12 685222 4053 63809445
Sinus bradycardia 15.80 10.60 161 685073 22732 63790766
Ligament rupture 15.79 10.60 61 685173 2475 63811023
Acute myeloid leukaemia recurrent 15.69 10.60 5 685229 2779 63810719
Rotator cuff repair 15.64 10.60 43 685191 1456 63812042
Haemorrhage subcutaneous 15.58 10.60 14 685220 4347 63809151
Wrong product administered 15.57 10.60 37 685197 7683 63805815
Appendix disorder 15.55 10.60 44 685190 1515 63811983
Reversible cerebral vasoconstriction syndrome 15.54 10.60 3 685231 2339 63811159
Oral disorder 15.54 10.60 154 685080 8767 63804731
Viral infection 15.48 10.60 498 684736 35642 63777856
Sinus disorder 15.41 10.60 259 684975 16649 63796849
Systemic mycosis 15.36 10.60 3 685231 2320 63811178
Urge incontinence 15.35 10.60 32 685202 904 63812594
Ileal stenosis 15.32 10.60 53 685181 2037 63811461
Exostosis of jaw 15.29 10.60 37 685197 1157 63812341
Lower limb fracture 15.23 10.60 215 685019 13330 63800168
Cytopenia 15.18 10.60 99 685135 15372 63798126
Inadequate analgesia 15.16 10.60 12 685222 3966 63809532
Uterine perforation 15.12 10.60 24 685210 5796 63807702
Synovial disorder 15.07 10.60 32 685202 916 63812582
Pseudomembranous colitis 15.05 10.60 18 685216 4898 63808600
Bacterial disease carrier 15.05 10.60 33 685201 966 63812532
Polyuria 15.04 10.60 76 685158 12567 63800931
Pulse absent 14.95 10.60 47 685187 8899 63804599
Premature delivery 14.90 10.60 279 684955 18310 63795188
Road traffic accident 14.87 10.60 430 684804 30315 63783183
Analgesic drug level increased 14.86 10.60 3 685231 2267 63811231
Micturition urgency 14.86 10.60 172 685062 10187 63803311
Nervous system disorder 14.84 10.60 165 685069 22913 63790585
Liver injury 14.82 10.60 226 685008 29706 63783792
Rib fracture 14.77 10.60 347 684887 23691 63789807
Patellofemoral pain syndrome 14.75 10.60 21 685213 432 63813066
Kidney infection 14.74 10.60 269 684965 17569 63795929
Amylase increased 14.74 10.60 53 685181 9632 63803866
Joint range of motion decreased 14.71 10.60 288 684946 19055 63794443
Hepatitis 14.70 10.60 370 684864 45212 63768286
Generalised oedema 14.66 10.60 146 685088 20707 63792791
Isosthenuria 14.65 10.60 11 685223 101 63813397
Acute chest syndrome 14.65 10.60 31 685203 885 63812613
Type I hypersensitivity 14.63 10.60 10 685224 3564 63809934
Red blood cell sedimentation rate 14.61 10.60 78 685156 3636 63809862
Disinhibition 14.61 10.60 3 685231 2240 63811258
Victim of child abuse 14.54 10.60 30 685204 841 63812657
Impaired fasting glucose 14.52 10.60 18 685216 322 63813176
Disturbance in social behaviour 14.47 10.60 12 685222 3875 63809623
Ingrown hair 14.43 10.60 24 685210 568 63812930
Atrioventricular block 14.42 10.60 72 685162 11943 63801555
Breast disorder 14.40 10.60 45 685189 1639 63811859
Pancreatic failure 14.36 10.60 41 685193 1419 63812079
Pneumonia bacterial 14.35 10.60 97 685137 14938 63798560
Secondary progressive multiple sclerosis 14.33 10.60 37 685197 1206 63812292
Blood lactate dehydrogenase increased 14.33 10.60 256 684978 32822 63780676
Pancreatitis acute 14.32 10.60 346 684888 42509 63770989
Pruritus 14.30 10.60 3631 681603 308769 63504729
Jaundice cholestatic 14.17 10.60 46 685188 8624 63804874
Injection site mass 14.12 10.60 260 684974 17010 63796488
Nerve compression 14.08 10.60 131 685103 7330 63806168
Hyperuricaemia 14.07 10.60 58 685176 10133 63803365
Bone metabolism disorder 14.06 10.60 20 685214 411 63813087
Breast feeding 14.06 10.60 26 685208 671 63812827
Spinal pain 14.06 10.60 200 685034 12421 63801077
Dehydration 14.01 10.60 2054 683180 214709 63598789
Skin laceration 13.95 10.60 349 684885 24068 63789430
Adverse event 13.89 10.60 532 684702 38957 63774541
Kidney transplant rejection 13.85 10.60 53 685181 9458 63804040
Systemic candida 13.82 10.60 22 685212 5307 63808191
Rash erythematous 13.80 10.60 402 684832 48231 63765267
Plantar fasciitis 13.79 10.60 63 685171 2757 63810741
Loose body in joint 13.78 10.60 36 685198 1182 63812316
Neuropathy peripheral 13.76 10.60 1068 684166 116457 63697041
Diverticulitis 13.76 10.60 521 684713 38097 63775401
Therapy cessation 13.74 10.60 447 684787 32042 63781456
Metastases to lymph nodes 13.73 10.60 47 685187 8670 63804828
Pelvic fracture 13.67 10.60 172 685062 10391 63803107
Multimorbidity 13.65 10.60 32 685202 980 63812518
Osteomalacia 13.63 10.60 39 685195 1352 63812146
Postpartum haemorrhage 13.62 10.60 40 685194 1407 63812091
Right ventricular failure 13.61 10.60 154 685080 21317 63792181
Oculogyric crisis 13.54 10.60 5 685229 2533 63810965
Post procedural haemorrhage 13.53 10.60 77 685157 12354 63801144
Premature labour 13.49 10.60 132 685102 7488 63806010
Vitamin B12 deficiency 13.48 10.60 102 685132 5370 63808128
Rebound effect 13.46 10.60 94 685140 4823 63808675
Chondropathy 13.42 10.60 55 685179 2294 63811204
Urticaria 13.40 10.60 1365 683869 145952 63667546
Blood culture positive 13.39 10.60 41 685193 7827 63805671
Decreased immune responsiveness 13.36 10.60 87 685147 4361 63809137
Spinal compression fracture 13.35 10.60 226 685008 14549 63798949
Dyspepsia 13.28 10.60 1008 684226 79304 63734194
Genital haemorrhage 13.22 10.60 24 685210 5498 63808000
Loose tooth 13.21 10.60 64 685170 2870 63810628
Right atrial hypertrophy 13.16 10.60 22 685212 523 63812975
Hypomania 13.15 10.60 25 685209 5629 63807869
Acute lymphocytic leukaemia recurrent 13.14 10.60 14 685220 4012 63809486
Hepatic necrosis 13.14 10.60 46 685188 8427 63805071
Hypoxic-ischaemic encephalopathy 13.09 10.60 36 685198 7116 63806382
Apathy 13.09 10.60 68 685166 11164 63802334
Lupus-like syndrome 13.08 10.60 147 685087 8644 63804854
Knee operation 13 10.60 88 685146 4469 63809029
Hepatitis acute 12.97 10.60 86 685148 13303 63800195
Stomatitis 12.92 10.60 1342 683892 108263 63705235
Cytomegalovirus infection reactivation 12.92 10.60 26 685208 5730 63807768
Cardiopulmonary failure 12.90 10.60 29 685205 6141 63807357
Hypersomnia 12.85 10.60 287 684947 19430 63794068
Autonomic nervous system imbalance 12.79 10.60 15 685219 4117 63809381
Neutropenic colitis 12.77 10.60 18 685216 4563 63808935
Dry mouth 12.76 10.60 774 684460 59644 63753854
Dairy intolerance 12.75 10.60 8 685226 53 63813445
Seasonal allergy 12.74 10.60 185 685049 11541 63801957
Hypomagnesaemia 12.70 10.60 301 684933 37075 63776423
Breast abscess 12.69 10.60 33 685201 1080 63812418
Blepharospasm 12.69 10.60 70 685164 3305 63810193
Rash morbilliform 12.61 10.60 22 685212 5119 63808379
Coronary artery stenosis 12.61 10.60 69 685165 11179 63802319
Long QT syndrome 12.60 10.60 22 685212 5117 63808381
Cartilage injury 12.59 10.60 37 685197 1302 63812196
Synovial fluid analysis 12.57 10.60 41 685193 1528 63811970
Rectocele 12.55 10.60 22 685212 544 63812954
Mitral valve prolapse 12.53 10.60 47 685187 1880 63811618
Asthma 12.49 10.60 857 684377 94368 63719130
Electrocardiogram ST segment depression 12.48 10.60 17 685217 4372 63809126
Hypernatraemia 12.47 10.60 77 685157 12112 63801386
Prescription drug used without a prescription 12.46 10.60 6 685228 2594 63810904
Tonsillitis 12.44 10.60 105 685129 5715 63807783
Linear IgA disease 12.41 10.60 7 685227 2767 63810731
Concussion 12.39 10.60 134 685100 7804 63805694
Ulcer 12.37 10.60 326 684908 22664 63790834
Nightmare 12.37 10.60 153 685081 20840 63792658
Ventricular arrhythmia 12.36 10.60 39 685195 7376 63806122
Iodine allergy 12.33 10.60 21 685213 507 63812991
CSF immunoglobulin increased 12.32 10.60 6 685228 22 63813476
Sensitive skin 12.28 10.60 31 685203 996 63812502
Retinal haemorrhage 12.27 10.60 39 685195 7359 63806139
Fracture displacement 12.26 10.60 34 685200 1157 63812341
Lipase increased 12.26 10.60 96 685138 14306 63799192
Fistula 12.23 10.60 158 685076 9603 63803895
Homicidal ideation 12.19 10.60 10 685224 3247 63810251
Delivery 12.19 10.60 21 685213 512 63812986
Strongyloidiasis 12.18 10.60 9 685225 3081 63810417
Acrochordon 12.13 10.60 28 685206 849 63812649
Pollakiuria 12.12 10.60 429 684805 31101 63782397
Lacrimal disorder 12.10 10.60 20 685214 471 63813027
Metastases to bone 12.02 10.60 149 685085 20286 63793212
Periprosthetic fracture 12.00 10.60 22 685212 564 63812934
JC polyomavirus test positive 11.99 10.60 35 685199 1227 63812271
Blood iron increased 11.96 10.60 37 685197 1340 63812158
Treatment failure 11.94 10.60 1417 683817 115399 63698099
Foetal distress syndrome 11.94 10.60 19 685215 433 63813065
Iron metabolism disorder 11.93 10.60 6 685228 24 63813474
Delusion 11.90 10.60 128 685106 17886 63795612
Chest wall tumour 11.85 10.60 7 685227 41 63813457
Deep vein thrombosis 11.83 10.60 959 684275 104223 63709275
Chest pain 11.82 10.60 2268 682966 233712 63579786
Areflexia 11.77 10.60 22 685212 4985 63808513
Blood disorder 11.76 10.60 118 685116 6739 63806759
Brain death 11.75 10.60 21 685213 4840 63808658
Parathyroid tumour benign 11.75 10.60 24 685210 668 63812830
Bacteraemia 11.74 10.60 208 685026 26703 63786795
Pulmonary arterial hypertension 11.73 10.60 194 685040 25173 63788325
Intraductal papillary mucinous neoplasm 11.71 10.60 22 685212 575 63812923
Cardiomyopathy 11.70 10.60 194 685040 25162 63788336
Alcohol abuse 11.69 10.60 21 685213 4831 63808667
Foetal death 11.64 10.60 105 685129 5825 63807673
Immune-mediated myositis 11.64 10.60 7 685227 2671 63810827
Extradural haematoma 11.62 10.60 7 685227 2669 63810829
Apraxia 11.59 10.60 6 685228 2489 63811009
Blood pH decreased 11.58 10.60 18 685216 4384 63809114
Hepatitis C 11.58 10.60 69 685165 10946 63802552
Tumour haemorrhage 11.56 10.60 12 685222 3481 63810017
Body temperature decreased 11.56 10.60 359 684875 25569 63787929
Cardiac failure chronic 11.54 10.60 53 685181 8988 63804510
Osteomyelitis 11.52 10.60 379 684855 27208 63786290
Radiation pneumonitis 11.51 10.60 11 685223 3317 63810181
Incorrect route of product administration 11.51 10.60 176 685058 23122 63790376
Dry skin 11.49 10.60 659 684575 50502 63762996
Cervical incompetence 11.48 10.60 20 685214 492 63813006
Collagen-vascular disease 11.45 10.60 8 685226 65 63813433
Hepatic cyst 11.44 10.60 95 685139 5145 63808353
Compartment syndrome 11.43 10.60 17 685217 4215 63809283
Confusional state 11.42 10.60 2527 682707 258617 63554881
Abscess oral 11.39 10.60 33 685201 1152 63812346
Ischaemic cardiomyopathy 11.37 10.60 36 685198 6802 63806696
Circulatory collapse 11.37 10.60 272 684962 33460 63780038
Central nervous system lesion 11.35 10.60 183 685051 11666 63801832
Renal tubular acidosis 11.33 10.60 9 685225 2970 63810528
Dialysis 11.27 10.60 120 685114 16800 63796698
Distributive shock 11.24 10.60 3 685231 1872 63811626
Bacterial sepsis 11.22 10.60 41 685193 7416 63806082
Vascular pseudoaneurysm 11.19 10.60 10 685224 3114 63810384
Blood calcium abnormal 11.18 10.60 34 685200 1220 63812278
Anger 11.16 10.60 110 685124 15631 63797867
Mucosal inflammation 11.14 10.60 547 684687 62037 63751461
Hypervitaminosis D 11.14 10.60 9 685225 93 63813405
Muscle rupture 11.13 10.60 65 685169 3135 63810363
Atrophic vulvovaginitis 11.12 10.60 33 685201 1168 63812330
Cold type haemolytic anaemia 11.07 10.60 15 685219 294 63813204
Mucous stools 11.07 10.60 66 685168 3207 63810291
Squamous cell carcinoma 11.06 10.60 208 685026 13661 63799837
Phospholipidosis 11.05 10.60 10 685224 122 63813376
Anaphylactoid reaction 10.98 10.60 21 685213 4717 63808781
Staphylococcal sepsis 10.97 10.60 86 685148 12813 63800685
Gingivitis 10.91 10.60 127 685107 7532 63805966
Animal bite 10.89 10.60 49 685185 2130 63811368
Cyst removal 10.88 10.60 17 685217 381 63813117
Urinary retention 10.83 10.60 420 684814 48781 63764717
Infection reactivation 10.83 10.60 4 685230 2026 63811472
Faecal calprotectin increased 10.81 10.60 71 685163 3569 63809929
Finger deformity 10.79 10.60 93 685141 5093 63808405
Lip ulceration 10.77 10.60 46 685188 1955 63811543
Uterine disorder 10.74 10.60 43 685191 1774 63811724
Colorectal cancer 10.74 10.60 11 685223 3210 63810288
Viral upper respiratory tract infection 10.73 10.60 134 685100 8081 63805417
Candida infection 10.68 10.60 253 684981 31166 63782332
Priapism 10.67 10.60 16 685218 3954 63809544
COVID-19 10.67 10.60 817 684417 64323 63749175
Ischaemic stroke 10.67 10.60 231 685003 28804 63784694
Adenoidal disorder 10.67 10.60 10 685224 128 63813370
Bone scan 10.67 10.60 3 685231 0 63813498
Blood selenium decreased 10.67 10.60 3 685231 0 63813498
Retinal neoplasm 10.67 10.60 3 685231 0 63813498
Urine viscosity increased 10.67 10.60 3 685231 0 63813498
Aneurysmal bone cyst 10.67 10.60 3 685231 0 63813498
Micrographic skin surgery 10.67 10.60 3 685231 0 63813498
Abortion missed 10.66 10.60 32 685202 1140 63812358
Red cell distribution width increased 10.66 10.60 187 685047 12122 63801376
Subdural haematoma 10.66 10.60 222 685012 27832 63785666
Gingival pain 10.65 10.60 109 685125 6258 63807240
Klebsiella infection 10.63 10.60 90 685144 13191 63800307
Temporomandibular joint syndrome 10.62 10.60 67 685167 3321 63810177

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A11CC05 ALIMENTARY TRACT AND METABOLISM
VITAMINS
VITAMIN A AND D, INCL. COMBINATIONS OF THE TWO
Vitamin D and analogues
ATC A11CC55 ALIMENTARY TRACT AND METABOLISM
VITAMINS
VITAMIN A AND D, INCL. COMBINATIONS OF THE TWO
Vitamin D and analogues
ATC M05BB03 MUSCULO-SKELETAL SYSTEM
DRUGS FOR TREATMENT OF BONE DISEASES
DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION
Bisphosphonates, combinations
ATC M05BB04 MUSCULO-SKELETAL SYSTEM
DRUGS FOR TREATMENT OF BONE DISEASES
DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION
Bisphosphonates, combinations
ATC M05BB05 MUSCULO-SKELETAL SYSTEM
DRUGS FOR TREATMENT OF BONE DISEASES
DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION
Bisphosphonates, combinations
ATC M05BB07 MUSCULO-SKELETAL SYSTEM
DRUGS FOR TREATMENT OF BONE DISEASES
DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION
Bisphosphonates, combinations
ATC M05BB08 MUSCULO-SKELETAL SYSTEM
DRUGS FOR TREATMENT OF BONE DISEASES
DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION
Bisphosphonates, combinations
ATC M05BB09 MUSCULO-SKELETAL SYSTEM
DRUGS FOR TREATMENT OF BONE DISEASES
DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION
Bisphosphonates, combinations
ATC M05BX53 MUSCULO-SKELETAL SYSTEM
DRUGS FOR TREATMENT OF BONE DISEASES
DRUGS AFFECTING BONE STRUCTURE AND MINERALIZATION
Other drugs affecting bone structure and mineralization
FDA CS M0022797 Vitamin D
MeSH PA D050071 Bone Density Conservation Agents
MeSH PA D000077264 Calcium-Regulating Hormones and Agents
MeSH PA D018977 Micronutrients
MeSH PA D014815 Vitamins
FDA EPC N0000175952 Vitamin D
CHEBI has role CHEBI:77746 Homo sapiens metabolite
CHEBI has role CHEBI:176497 geroprotectors

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Osteomalacia indication 4598005 DOID:10573
Hypocalcemia indication 5291005
Vitamin D deficiency indication 34713006
Hypoparathyroidism indication 36976004 DOID:11199
Rickets indication 41345002 DOID:10609
Osteoporosis indication 64859006 DOID:11476
Vitamin deficiency indication 85670002
Postmenopausal osteoporosis indication 102447009
Prevention of dental caries indication 426482000
Glucocorticoid Induced Osteoporosis indication
Hypogonadal Osteoporosis in Males indication
Vitamin D Dependent Rickets indication
Renal osteodystrophy off-label use 16726004 DOID:13068
Anticonvulsant-induced Osteomalacia off-label use
Gastritis contraindication 4556007 DOID:4029
Poisoning by digitalis glycoside contraindication 12876009
Constipation contraindication 14760008 DOID:2089
Esophagitis contraindication 16761005 DOID:11963
Primary hyperoxaluria contraindication 17901006 DOID:2977
Hyperphosphatemia contraindication 20165001 DOID:0050459
Hypervitaminosis D contraindication 27712000 DOID:9971
Dental fluorosis contraindication 30265004
Ulcer of esophagus contraindication 30811009
Sarcoidosis contraindication 31541009 DOID:11335
Dehydration contraindication 34095006
Hypertensive disorder contraindication 38341003 DOID:10763
Dysphagia contraindication 40739000
Achalasia of esophagus contraindication 45564002 DOID:9164
Atrial fibrillation contraindication 49436004 DOID:0060224
Vitamin E deficiency contraindication 54137008
Hyperlipidemia contraindication 55822004 DOID:1168
Joint pain contraindication 57676002
Acute nephropathy contraindication 58574008
Diarrhea contraindication 62315008
Stricture of esophagus contraindication 63305008
Hypervitaminosis A contraindication 64559002 DOID:9972
Blood coagulation disorder contraindication 64779008 DOID:1247
Hypercalcemia contraindication 66931009 DOID:12678
Hyperparathyroidism contraindication 66999008 DOID:13543
Fracture of femur contraindication 71620000
Hypercalciuria contraindication 71938000
Duodenitis contraindication 72007001 DOID:8643
Diabetes mellitus contraindication 73211009 DOID:9351
Kidney disease contraindication 90708001 DOID:557
Kidney stone contraindication 95570007
Anemia due to enzyme deficiency contraindication 111577008
Neoplasm of endometrium contraindication 123844007 DOID:1380
Neoplasm of prostate contraindication 126906006 DOID:10283
Hb SS disease contraindication 127040003 DOID:10923
Bed-ridden contraindication 160685001
Acute peptic ulcer contraindication 196682000
Osteolysis contraindication 203522001
Disease of liver contraindication 235856003 DOID:409
Esophageal dysmotility contraindication 266434009 DOID:9192
Arteriosclerosis obliterans contraindication 361133006 DOID:5160
Malignant tumor of cervix contraindication 363354003 DOID:4362
Hemochromatosis contraindication 399187006 DOID:2352
Central nervous system depression contraindication 418072004
Aseptic necrosis of bone of jaw contraindication 441809006
Carcinoma of female breast contraindication 447782002
Vitamin K Deficiency Induced Hypoprothrombinemia contraindication
Malabsorption States contraindication
High Grade Dysplasia associated with Barrett's Esophagus contraindication
Esophageal Obstruction contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

None

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Vitamin D3 receptor Nuclear hormone receptor AGONIST EC50 9.68 CHEMBL CHEMBL
Glycine receptor subunit alpha-1 Ion channel EC50 6.40 CHEMBL
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial Enzyme WOMBAT-PK
Vitamin D 25-hydroxylase Enzyme WOMBAT-PK
Sterol 26-hydroxylase, mitochondrial Enzyme WOMBAT-PK
Vitamin D3 receptor Nuclear hormone receptor EC50 6.05 CHEMBL

External reference:

IDSource
D00188 KEGG_DRUG
4017667 VANDF
C0008318 UMLSCUI
CHEBI:28940 CHEBI
VD3 PDB_CHEM_ID
CHEMBL1042 ChEMBL_ID
DB00169 DRUGBANK_ID
2747 IUPHAR_LIGAND_ID
5280795 PUBCHEM_CID
1244014 RXNORM
15676 MMSL
199274 MMSL
4434 MMSL
4868 MMSL
4871 MMSL
d03129 MMSL
001014 NDDF
108943009 SNOMEDCT_US
18414002 SNOMEDCT_US
D002762 MESH_DESCRIPTOR_UI
1497 INN_ID
1C6V77QF41 UNII

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
FOSAMAX PLUS D HUMAN PRESCRIPTION DRUG LABEL 2 0006-0270 TABLET 5600 [iU] ORAL NDA 27 sections
FOSAMAX PLUS D HUMAN PRESCRIPTION DRUG LABEL 2 0006-0710 TABLET 2800 [iU] ORAL NDA 27 sections
NataFort HUMAN PRESCRIPTION DRUG LABEL 10 0178-0716 TABLET 400 [iU] ORAL Unapproved drug other 12 sections
CitraNatal Harmony 3.0 HUMAN PRESCRIPTION DRUG LABEL 8 0178-0796 CAPSULE, GELATIN COATED 400 [iU] ORAL unapproved drug other 10 sections
CitraNatal Harmony HUMAN PRESCRIPTION DRUG LABEL 8 0178-0798 CAPSULE, GELATIN COATED 400 [iU] ORAL UNAPPROVED DRUG OTHER 11 sections
CitraNatal Harmony HUMAN PRESCRIPTION DRUG LABEL 8 0178-0799 CAPSULE, GELATIN COATED 400 [iU] ORAL Unapproved drug other 11 sections
CitraNatal Harmony HUMAN PRESCRIPTION DRUG LABEL 8 0178-0812 CAPSULE, GELATIN COATED 400 [iU] ORAL Unapproved drug other 11 sections
CitraNatal Medley HUMAN PRESCRIPTION DRUG LABEL 8 0178-0896 CAPSULE, GELATIN COATED 200 [iU] ORAL unapproved drug other 10 sections
Select OB HUMAN PRESCRIPTION DRUG LABEL 15 0642-0077 TABLET, CHEWABLE 400 [iU] ORAL UNAPPROVED DRUG OTHER 14 sections
Vitafol Ultra HUMAN PRESCRIPTION DRUG LABEL 17 0642-0093 CAPSULE, LIQUID FILLED 25 ug ORAL UNAPPROVED DRUG OTHER 13 sections
Vitafol Nano HUMAN PRESCRIPTION DRUG LABEL 7 0642-0094 TABLET, COATED 25 ug ORAL UNAPPROVED DRUG OTHER 14 sections
Select OB HUMAN PRESCRIPTION DRUG LABEL 15 0642-0120 TABLET, CHEWABLE 400 [iU] ORAL UNAPPROVED DRUG OTHER 13 sections
Strovite One Caplets HUMAN PRESCRIPTION DRUG LABEL 20 0642-0207 TABLET 25 ug ORAL UNAPPROVED DRUG OTHER 14 sections
Vitafol HUMAN PRESCRIPTION DRUG LABEL 4 0642-7468 STRIP 1000 [iU] ORAL Unapproved drug other 13 sections
Vitafol Fe Plus HUMAN PRESCRIPTION DRUG LABEL 17 0642-7473 CAPSULE, LIQUID FILLED 25 mg ORAL UNAPPROVED DRUG OTHER 14 sections
Marnatal F HUMAN PRESCRIPTION DRUG LABEL 13 0682-1570 CAPSULE 400 [iU] ORAL UNAPPROVED DRUG OTHER 4 sections
O-Cal Prenatal Vitamin HUMAN PRESCRIPTION DRUG LABEL 16 0813-0202 TABLET 400 [iU] ORAL UNAPPROVED DRUG OTHER 6 sections
Dialyvite Supreme D HUMAN PRESCRIPTION DRUG LABEL 13 10542-009 TABLET, COATED 2000 [iU] ORAL Unapproved drug other 7 sections
PRENATAL PLUS HUMAN PRESCRIPTION DRUG LABEL 15 10544-549 TABLET, FILM COATED 400 [iU] ORAL unapproved drug other 8 sections
PRENATAL PLUS IRON HUMAN PRESCRIPTION DRUG LABEL 15 10544-609 TABLET, FILM COATED 400 [iU] ORAL UNAPPROVED DRUG OTHER 7 sections
Se-Natal 19 HUMAN PRESCRIPTION DRUG LABEL 15 13925-116 TABLET 400 [iU] ORAL unapproved drug other 15 sections
Se-Natal 19 HUMAN PRESCRIPTION DRUG LABEL 15 13925-116 TABLET 400 [iU] ORAL unapproved drug other 15 sections
Se-Natal 19 Chewable HUMAN PRESCRIPTION DRUG LABEL 14 13925-117 TABLET, CHEWABLE 400 [iU] ORAL unapproved drug other 16 sections
PRENATAL PLUS HUMAN PRESCRIPTION DRUG LABEL 15 15338-522 TABLET, FILM COATED 400 [iU] ORAL unapproved drug other 8 sections
Quflora Pediatric Drops HUMAN PRESCRIPTION DRUG LABEL 13 15370-100 LIQUID 400 [iU] ORAL UNAPPROVED DRUG OTHER 11 sections
Quflora Pediatric Drops HUMAN PRESCRIPTION DRUG LABEL 13 15370-101 LIQUID 400 [iU] ORAL UNAPPROVED DRUG OTHER 11 sections
Quflora FE Pediatric Drops HUMAN PRESCRIPTION DRUG LABEL 14 15370-102 LIQUID 400 [iU] ORAL UNAPPROVED DRUG OTHER 11 sections
Quflora Pediatric HUMAN PRESCRIPTION DRUG LABEL 14 15370-103 TABLET, CHEWABLE 400 [iU] ORAL UNAPPROVED DRUG OTHER 12 sections
Quflora Pediatric HUMAN PRESCRIPTION DRUG LABEL 14 15370-104 TABLET, CHEWABLE 400 [iU] ORAL UNAPPROVED DRUG OTHER 12 sections
Quflora Pediatric HUMAN PRESCRIPTION DRUG LABEL 14 15370-105 TABLET, CHEWABLE 400 [iU] ORAL UNAPPROVED DRUG OTHER 12 sections