pyridoxine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
2836 65-23-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • pyridoxine
  • adermin
  • bezatin
  • pirivitol
  • pyridoxin
  • pyridoxine hydrochloride
  • pyridoxine (vit B6)
  • vitamin b6
  • pyridoxine HCl
The 4-methanol form of VITAMIN B 6 which is converted to PYRIDOXAL PHOSPHATE which is a coenzyme for synthesis of amino acids, neurotransmitters (serotonin, norepinephrine), sphingolipids, aminolevulinic acid. Although pyridoxine and Vitamin B 6 are still frequently used as synonyms, especially by medical researchers, this practice is erroneous and sometimes misleading (EE Snell; Ann NY Acad Sci, vol 585 pg 1, 1990).
  • Molecular weight: 169.18
  • Formula: C8H11NO3
  • CLOGP: -0.34
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 3
  • TPSA: 73.58
  • ALOGS: -1.02
  • ROTB: 2
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.16 g O
0.16 g P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 222 mg/mL Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 39.43 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
Vd (Volume of distribution) 0.66 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 7.90 mL/min/kg Lombardo F, Berellini G, Obach RS
t_half (Half-life) 0.98 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Dec. 29, 1993 FDA HOSPIRA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pemphigus 1713.98 9.96 3873 452428 153339 55682427
Rheumatoid arthritis 1613.20 9.96 6747 449554 375857 55459909
Systemic lupus erythematosus 1605.83 9.96 4104 452197 175974 55659792
Glossodynia 1427.14 9.96 3540 452761 148918 55686848
Hand deformity 1151.39 9.96 3020 453281 131472 55704294
Arthropathy 1062.12 9.96 3802 452499 196473 55639293
Abdominal discomfort 1011.07 9.96 4686 451615 272588 55563178
Alopecia 1004.32 9.96 4869 451432 288589 55547177
Wound 957.28 9.96 2882 453419 135922 55699844
Maternal exposure during pregnancy 944.58 9.96 3527 452774 186026 55649740
Completed suicide 832.42 9.96 67 456234 133766 55702000
Synovitis 761.63 9.96 2951 453350 158354 55677412
Pericarditis 746.31 9.96 2257 454044 106666 55729100
Anti-cyclic citrullinated peptide antibody positive 728.78 9.96 2099 454202 96501 55739265
Discomfort 717.53 9.96 2652 453649 139109 55696657
Infusion related reaction 713.23 9.96 3466 452835 205465 55630301
Contraindicated product administered 696.18 9.96 3173 453128 183113 55652653
Swelling 681.06 9.96 3779 452522 235992 55599774
Joint swelling 646.32 9.96 4289 452012 285511 55550255
Toxicity to various agents 634.48 9.96 533 455768 224031 55611735
Pain 565.77 9.96 8005 448296 655179 55180587
Death 496.06 9.96 1289 455012 340137 55495629
Product use issue 461.98 9.96 2831 453470 183210 55652556
Duodenal ulcer perforation 449.93 9.96 1397 454904 66945 55768821
Helicobacter infection 437.19 9.96 1448 454853 71820 55763946
Rheumatoid factor positive 436.56 9.96 1392 454909 67668 55768098
Hepatic enzyme increased 411.65 9.96 2586 453715 168798 55666968
Arthralgia 380.44 9.96 5938 450363 495731 55340035
Drug abuse 378.60 9.96 50 456251 67560 55768206
Intentional overdose 368.27 9.96 56 456245 68061 55767705
Drug interaction 363.50 9.96 719 455582 209036 55626730
Therapeutic product effect decreased 312.94 9.96 2398 453903 167054 55668712
Drug intolerance 305.51 9.96 3386 452915 261432 55574334
Exposure during pregnancy 302.53 9.96 2017 454284 134325 55701441
Musculoskeletal stiffness 288.18 9.96 2208 454093 153799 55681967
Treatment failure 282.25 9.96 2352 453949 168040 55667726
Febrile neutropenia 243.60 9.96 298 456003 105247 55730519
Hip arthroplasty 242.60 9.96 777 455524 37846 55797920
Acute kidney injury 231.64 9.96 1083 455218 239680 55596086
Knee arthroplasty 228.55 9.96 834 455467 43425 55792341
Psoriatic arthropathy 227.43 9.96 1193 455108 72815 55762951
Cardiac arrest 224.22 9.96 221 456080 86093 55749673
Overdose 221.63 9.96 321 455980 105509 55730257
Hypersensitivity 220.94 9.96 3105 453196 253303 55582463
Suicide attempt 220.73 9.96 96 456205 57740 55778026
Depressed level of consciousness 219.64 9.96 91 456210 56342 55779424
Nasopharyngitis 200.57 9.96 2701 453600 218258 55617508
Impaired healing 186.07 9.96 1274 455027 85567 55750199
Rheumatic fever 183.83 9.96 583 455718 28244 55807522
Constipation 170.54 9.96 950 455351 200993 55634773
Disease progression 169.80 9.96 375 455926 104798 55730968
Nausea 168.06 9.96 4817 451484 759361 55076405
Red blood cell sedimentation rate abnormal 167.29 9.96 427 455874 18246 55817520
Malignant neoplasm progression 166.38 9.96 211 456090 73376 55762390
Swollen joint count increased 165.23 9.96 501 455800 23683 55812083
Diarrhoea 163.69 9.96 3936 452365 634571 55201195
Device expulsion 162.36 9.96 26 456275 30423 55805343
Sedation 160.53 9.96 42 456259 34812 55800954
Neutropenia 157.04 9.96 703 455598 157464 55678302
Muscle injury 150.19 9.96 830 455471 51670 55784096
Bradycardia 150.09 9.96 196 456105 67308 55768458
Blister 149.81 9.96 1444 454857 107443 55728323
Folliculitis 149.23 9.96 857 455444 54122 55781644
Hypotension 146.56 9.96 1311 454990 249197 55586569
Lactic acidosis 145.83 9.96 52 456249 35294 55800472
Cardiac failure 144.09 9.96 279 456022 81814 55753952
Anxiety 141.53 9.96 950 455351 192222 55643544
Sleep disorder due to general medical condition, insomnia type 140.32 9.96 709 455592 42629 55793137
Hyponatraemia 139.34 9.96 397 455904 101742 55734024
C-reactive protein abnormal 139.34 9.96 630 455671 36179 55799587
Drug hypersensitivity 132.49 9.96 1509 454792 273696 55562070
Somnolence 128.18 9.96 787 455514 162626 55673140
Sickle cell anaemia with crisis 128.14 9.96 180 456121 4848 55830918
Tremor 127.02 9.96 527 455774 120562 55715204
Pregnancy 126.26 9.96 567 455734 32466 55803300
Asthenia 124.43 9.96 1993 454308 340980 55494786
Drug ineffective 123.18 9.96 8832 447469 910157 54925609
Fatigue 121.46 9.96 7668 448633 780884 55054882
Rash 120.64 9.96 5013 451288 488034 55347732
Irritable bowel syndrome 120.19 9.96 958 455343 67500 55768266
Lower respiratory tract infection 120.03 9.96 1441 454860 113353 55722413
Agitation 119.22 9.96 168 456133 55868 55779898
Respiratory arrest 118.17 9.96 50 456251 30575 55805191
Renal failure 115.84 9.96 481 455820 110019 55725747
Asthma 115.06 9.96 496 455805 112274 55723492
Vomiting 111.27 9.96 3132 453169 495096 55340670
Dyspnoea 109.18 9.96 3821 452480 588756 55247010
Osteoarthritis 108.03 9.96 1060 455241 79236 55756530
Sopor 106.86 9.96 20 456281 20902 55814864
Dizziness 105.82 9.96 2284 454017 373856 55461910
Rhabdomyolysis 105.67 9.96 104 456197 40554 55795212
Syncope 104.90 9.96 485 455816 107714 55728052
Electrocardiogram QT prolonged 103.39 9.96 177 456124 54411 55781355
Intentional self-injury 102.71 9.96 37 456264 24955 55810811
Hyperhidrosis 102.11 9.96 404 455897 93684 55742082
Arthritis 100.71 9.96 1245 455056 98607 55737159
Multiple sclerosis relapse 99.17 9.96 131 456170 44772 55790994
Cardio-respiratory arrest 97.07 9.96 188 456113 55133 55780633
Drug dependence 94.94 9.96 32 456269 22501 55813265
Drug reaction with eosinophilia and systemic symptoms 94.26 9.96 65 456236 30239 55805527
Condition aggravated 91.90 9.96 3540 452761 341358 55494408
Tachycardia 90.97 9.96 495 455806 105381 55730385
Blood cholesterol increased 90.83 9.96 944 455357 71635 55764131
Hypoglycaemia 90.06 9.96 199 456102 55616 55780150
Myalgia 89.44 9.96 664 455637 131361 55704405
Abortion spontaneous 89.03 9.96 634 455667 43119 55792647
Neoplasm progression 89 9.96 77 456224 31939 55803827
Live birth 88.48 9.96 354 455947 19251 55816515
Drug withdrawal syndrome 86.54 9.96 51 456250 25806 55809960
Cognitive disorder 86.18 9.96 167 456134 48966 55786800
Product quality issue 85.02 9.96 79 456222 31657 55804109
Serotonin syndrome 83.49 9.96 56 456245 26434 55809332
Type 2 diabetes mellitus 82.35 9.96 656 455645 46206 55789560
Pulmonary arterial hypertension 82.23 9.96 57 456244 26446 55809320
Cardiac failure congestive 79.33 9.96 403 455898 87317 55748449
Peripheral swelling 78.12 9.96 2472 453829 232254 55603512
Sedation complication 77.97 9.96 4 456297 11668 55824098
No adverse event 77.42 9.96 109 456192 36265 55799501
Intentional product use issue 76.73 9.96 1185 455116 98548 55737218
Hypoxia 75.33 9.96 207 456094 53690 55782076
Metabolic acidosis 74.94 9.96 133 456168 40321 55795445
Coma 74.80 9.96 241 456060 59414 55776352
Renal impairment 74.59 9.96 368 455933 80345 55755421
Ill-defined disorder 74.51 9.96 867 455434 67676 55768090
Hyperglycaemia 73.52 9.96 123 456178 38158 55797608
Blood pressure fluctuation 73.13 9.96 569 455732 39791 55795975
Balance disorder 72.39 9.96 346 455955 76174 55759592
Plasma cell myeloma 71.47 9.96 171 456130 46475 55789291
Foot deformity 71.04 9.96 381 455920 23444 55812322
Respiratory failure 70.80 9.96 465 455836 94597 55741169
Joint effusion 70.46 9.96 273 456028 14625 55821141
Liver injury 69.85 9.96 579 455722 41269 55794497
Depression 69.47 9.96 1034 455267 179083 55656683
Feeling abnormal 69.20 9.96 720 455581 132882 55702884
Thrombocytopenia 68.59 9.96 739 455562 135485 55700281
Orthostatic hypotension 68.19 9.96 102 456199 33097 55802669
Insomnia 68.07 9.96 1119 455182 190741 55645025
Multiple organ dysfunction syndrome 67.69 9.96 211 456090 52559 55783207
Fibromyalgia 67.51 9.96 760 455541 58843 55776923
Dehydration 67.20 9.96 895 455406 157930 55677836
Pulmonary embolism 66.83 9.96 551 455750 106573 55729193
Anaemia 66.81 9.96 1654 454647 265857 55569909
Sinusitis 66.55 9.96 2084 454217 195497 55640269
Encephalopathy 66.47 9.96 115 456186 35210 55800556
Chest discomfort 66.07 9.96 499 455802 98358 55737408
Red blood cell sedimentation rate increased 65.08 9.96 514 455787 36109 55799657
Contusion 64.53 9.96 1428 454873 127002 55708764
Seizure 64.51 9.96 675 455626 124444 55711322
Drug resistance 63.97 9.96 44 456257 20498 55815268
Hallucination 63.41 9.96 196 456105 48953 55786813
Hepatic failure 62.11 9.96 110 456191 33376 55802390
Hyperkalaemia 61.35 9.96 209 456092 50656 55785110
Blood glucose increased 60.94 9.96 358 455943 74793 55760973
Cytomegalovirus infection 60.53 9.96 41 456260 19255 55816511
Cholestasis 59.95 9.96 78 456223 26835 55808931
Urticaria 59.49 9.96 820 455481 143856 55691910
Disability assessment scale score increased 59.45 9.96 91 456210 2653 55833113
Muscle spasticity 59.23 9.96 45 456256 19915 55815851
Intentional product misuse 59.19 9.96 216 456085 51288 55784478
Vision blurred 59.13 9.96 411 455890 82532 55753234
Creatinine renal clearance decreased 59.07 9.96 22 456279 14537 55821229
Hepatocellular injury 58.90 9.96 77 456224 26437 55809329
Injection site erythema 58.72 9.96 918 455383 76530 55759236
Fluid retention 58.15 9.96 233 456068 53845 55781921
Angioedema 58.08 9.96 159 456142 41294 55794472
Mental status changes 57.83 9.96 137 456164 37364 55798402
Blood pressure diastolic abnormal 57.71 9.96 216 456085 11382 55824384
Hepatic function abnormal 57.58 9.96 121 456180 34437 55801329
Infection 57.32 9.96 2072 454229 198134 55637632
Tuberculosis 57.05 9.96 208 456093 10821 55824945
Emotional distress 56.82 9.96 96 456205 29667 55806099
Myocardial infarction 56.43 9.96 481 455820 92389 55743377
Altered state of consciousness 56.31 9.96 62 456239 22959 55812807
Suicidal ideation 55.84 9.96 259 456042 57483 55778283
Basal cell carcinoma 55.76 9.96 373 455928 24848 55810918
Mydriasis 55.66 9.96 11 456290 11060 55824706
Loss of consciousness 55.52 9.96 592 455709 108757 55727009
Anaphylactic reaction 54.49 9.96 269 456032 58726 55777040
Bone erosion 54.22 9.96 253 456048 14721 55821045
Osteoporosis 54.18 9.96 653 455648 51399 55784367
Metastases to bone 54.12 9.96 47 456254 19461 55816305
Caesarean section 54.02 9.96 266 456035 15825 55819941
Grip strength decreased 53.34 9.96 267 456034 15989 55819777
Respiratory disorder 53.20 9.96 123 456178 33834 55801932
Joint laxity 53.01 9.96 81 456220 2358 55833408
Injection site pruritus 52.74 9.96 546 455755 41385 55794381
Shock 52.62 9.96 59 456242 21669 55814097
Disturbance in attention 52.50 9.96 116 456185 32424 55803342
Hypothermia 52.03 9.96 18 456283 12452 55823314
Schizophrenia 51.61 9.96 11 456290 10488 55825278
Neutrophil count decreased 51.48 9.96 218 456083 49604 55786162
Blood pressure decreased 51.29 9.96 275 456026 58775 55776991
Weight increased 50.91 9.96 2313 453988 227390 55608376
Diabetic ketoacidosis 50.52 9.96 47 456254 18824 55816942
Blood pressure systolic abnormal 50.25 9.96 184 456117 9593 55826173
Macular degeneration 49.55 9.96 48 456253 18860 55816906
Disorientation 49.40 9.96 143 456158 36470 55799296
Leukopenia 49.35 9.96 354 455947 70586 55765180
Ejection fraction decreased 49.01 9.96 53 456248 19788 55815978
Osteonecrosis of jaw 48.97 9.96 125 456176 33233 55802533
Muscle spasms 48.11 9.96 803 455498 136568 55699198
Pain in jaw 47.95 9.96 165 456136 39871 55795895
Restlessness 47.82 9.96 89 456212 26497 55809269
Blood pressure systolic increased 47.74 9.96 524 455777 40312 55795454
Poisoning 47.73 9.96 22 456279 12791 55822975
Deep vein thrombosis 47.52 9.96 397 455904 76580 55759186
Speech disorder 47.32 9.96 151 456150 37342 55798424
Unresponsive to stimuli 47.26 9.96 118 456183 31607 55804159
Foetal exposure during pregnancy 46.69 9.96 449 455852 33374 55802392
Extrapyramidal disorder 46.36 9.96 21 456280 12335 55823431
Maternal exposure before pregnancy 46.27 9.96 141 456160 6682 55829084
Dyspnoea exertional 46.23 9.96 257 456044 54432 55781334
Hospitalisation 46.21 9.96 387 455914 74613 55761153
Cerebral haemorrhage 46.13 9.96 102 456199 28504 55807262
Loss of personal independence in daily activities 45.81 9.96 920 455381 80449 55755317
Product use in unapproved indication 45.53 9.96 835 455466 139987 55695779
Flushing 45.35 9.96 357 455944 69743 55766023
Drug level increased 45.21 9.96 61 456240 20664 55815102
Disseminated intravascular coagulation 45.04 9.96 47 456254 17838 55817928
Blood alkaline phosphatase increased 44.97 9.96 163 456138 38782 55796984
Blood creatine phosphokinase increased 44.80 9.96 100 456201 27852 55807914
Multiple fractures 44.55 9.96 146 456155 7195 55828571
Atrial fibrillation 44.47 9.96 618 455683 108279 55727487
Anaphylactic shock 44.44 9.96 67 456234 21673 55814093
Product administration error 44.25 9.96 63 456238 20866 55814900
Neuropathy peripheral 44.16 9.96 578 455723 102315 55733451
Blood calcium decreased 44.15 9.96 78 456223 23691 55812075
Hypokalaemia 44.10 9.96 521 455780 93916 55741850
Stomatitis 44.06 9.96 1287 455014 119523 55716243
Pulmonary fibrosis 44.06 9.96 401 455900 29357 55806409
Pulmonary oedema 43.97 9.96 239 456062 50904 55784862
Premature labour 43.94 9.96 202 456099 11680 55824086
Torsade de pointes 43.85 9.96 23 456278 12417 55823349
Palpitations 43.11 9.96 559 455742 99113 55736653
COVID-19 42.84 9.96 395 455906 74663 55761103
Ascites 42.78 9.96 158 456143 37386 55798380
Drug ineffective for unapproved indication 42.77 9.96 90 456211 25603 55810163
Wrong technique in product usage process 42.56 9.96 286 456015 57882 55777884
Dysphagia 42.26 9.96 442 455859 81505 55754261
Chronic kidney disease 42.24 9.96 186 456115 41870 55793896
Decreased appetite 41.91 9.96 1406 454895 217825 55617941
Gamma-glutamyltransferase increased 41.90 9.96 121 456180 30884 55804882
Metastases to liver 41.78 9.96 69 456232 21517 55814249
C-reactive protein increased 41.45 9.96 881 455420 77803 55757963
Posterior reversible encephalopathy syndrome 41.27 9.96 41 456260 15919 55819847
White blood cell count decreased 41.05 9.96 746 455555 125244 55710522
Respiratory depression 40.95 9.96 25 456276 12410 55823356
Abnormal behaviour 40.94 9.96 63 456238 20209 55815557
Joint range of motion decreased 40.76 9.96 348 455953 25017 55810749
Neck deformity 40.63 9.96 65 456236 1970 55833796
Dysgeusia 40.46 9.96 182 456119 40733 55795033
Bone pain 40.19 9.96 240 456061 49945 55785821
Acute hepatic failure 40.16 9.96 45 456256 16533 55819233
Accidental overdose 39.98 9.96 65 456236 20396 55815370
Gestational diabetes 39.97 9.96 150 456151 7914 55827852
Pulmonary hypertension 39.83 9.96 153 456148 35791 55799975
Drug tolerance decreased 39.66 9.96 214 456087 13197 55822569
Blood bilirubin increased 39.58 9.96 138 456163 33216 55802550
Injection site reaction 39.16 9.96 628 455673 52619 55783147
Disability 38.96 9.96 240 456061 15540 55820226
Cerebrovascular accident 38.89 9.96 568 455733 98702 55737064
Platelet count decreased 38.85 9.96 617 455684 105766 55730000
Joint destruction 38.62 9.96 109 456192 4946 55830820
Pleural effusion 38.61 9.96 475 455826 85005 55750761
Inflammation 38.56 9.96 780 455521 68291 55767475
Blood pressure diastolic decreased 38.14 9.96 278 456023 19045 55816721
Maternal drugs affecting foetus 38.12 9.96 109 456192 4984 55830782
Dysarthria 37.88 9.96 178 456123 39372 55796394
Aspartate aminotransferase increased 37.69 9.96 458 455843 82144 55753622
Alanine aminotransferase increased 37.36 9.96 534 455767 93128 55742638
Rheumatoid nodule 37.33 9.96 227 456074 14630 55821136
Accidental exposure to product 37.24 9.96 91 456210 24556 55811210
Memory impairment 37.22 9.96 486 455815 86071 55749695
International normalised ratio increased 37.20 9.96 207 456094 43834 55791932
Arrhythmia 37.18 9.96 152 456149 34931 55800835
Melaena 37.07 9.96 112 456189 28178 55807588
Haemorrhage 37.04 9.96 286 456015 56111 55779655
Cytokine release syndrome 37.03 9.96 21 456280 10854 55824912
Withdrawal syndrome 36.69 9.96 58 456243 18404 55817362
Ventricular tachycardia 36.61 9.96 50 456251 16851 55818915
Chest pain 36.56 9.96 1216 455085 188581 55647185
Delirium 36.37 9.96 199 456102 42318 55793448
Device difficult to use 36.33 9.96 21 456280 10740 55825026
Gastrointestinal haemorrhage 36.24 9.96 417 455884 75534 55760232
Device dislocation 36.13 9.96 81 456220 22525 55813241
Joint stiffness 35.81 9.96 442 455859 34983 55800783
Back pain 35.45 9.96 1566 454735 235604 55600162
Infective pulmonary exacerbation of cystic fibrosis 35.39 9.96 11 456290 8146 55827620
Sepsis 35.29 9.96 863 455438 138977 55696789
Akathisia 35.23 9.96 13 456288 8639 55827127
Coagulopathy 35.14 9.96 61 456240 18655 55817111
Multiple sclerosis 35.07 9.96 112 456189 27690 55808076
Polyarthritis 35.00 9.96 152 456149 8576 55827190
Inappropriate antidiuretic hormone secretion 34.81 9.96 36 456265 13720 55822046
Vertigo 34.79 9.96 279 456022 54293 55781473
Injection site swelling 34.34 9.96 520 455781 43058 55792708
Palmar-plantar erythrodysaesthesia syndrome 34.06 9.96 75 456226 20990 55814776
Psychotic disorder 34.03 9.96 89 456212 23469 55812297
Latent tuberculosis 33.35 9.96 67 456234 2435 55833331
Nightmare 33.30 9.96 53 456248 16773 55818993
Nodule 32.90 9.96 261 456040 18358 55817408
Enthesopathy 32.78 9.96 141 456160 7922 55827844
Diabetes mellitus inadequate control 32.73 9.96 39 456262 13941 55821825
Laryngitis 32.61 9.96 209 456092 13721 55822045
Acute respiratory failure 32.40 9.96 135 456166 30859 55804907
Ventricular fibrillation 32.10 9.96 25 456276 10927 55824839
Polyneuropathy 32.08 9.96 35 456266 13015 55822751
Eosinophilia 32.04 9.96 72 456229 20005 55815761
Respiratory distress 31.83 9.96 140 456161 31527 55804239
Juvenile idiopathic arthritis 31.77 9.96 98 456203 4675 55831091
Ventricular septal defect 31.39 9.96 89 456212 4049 55831717
Blood creatinine increased 31.35 9.96 459 455842 79732 55756034
Bronchospasm 31.35 9.96 49 456252 15620 55820146
Joint dislocation 31.18 9.96 227 456074 15546 55820220
Thrombotic microangiopathy 30.88 9.96 19 456282 9392 55826374
Product dose omission issue 30.78 9.96 1351 454950 203402 55632364
Pre-eclampsia 30.45 9.96 143 456158 8343 55827423
Acute myeloid leukaemia 30.36 9.96 57 456244 16915 55818851
Neuroleptic malignant syndrome 30.24 9.96 29 456272 11449 55824317
Lupus-like syndrome 30.05 9.96 188 456113 12239 55823527
Tenderness 30.04 9.96 272 456029 19883 55815883
Stress cardiomyopathy 30.00 9.96 15 456286 8321 55827445
Musculoskeletal pain 29.98 9.96 866 455435 80286 55755480
Pancreatitis acute 29.77 9.96 104 456197 25020 55810746
Limb deformity 29.77 9.96 84 456217 3811 55831955
Gastrointestinal disorder 29.72 9.96 1156 455145 111546 55724220
Abdominal pain 29.63 9.96 1756 454545 257049 55578717
Irritability 29.63 9.96 131 456170 29457 55806309
Disease recurrence 29.48 9.96 97 456204 23763 55812003
Premature rupture of membranes 29.13 9.96 95 456206 4670 55831096
Hypervolaemia 29.07 9.96 113 456188 26345 55809421
Cardiogenic shock 29.05 9.96 55 456246 16270 55819496
Hemiparesis 28.94 9.96 84 456217 21406 55814360
Psoriasis 28.91 9.96 969 455332 91723 55744043
Face oedema 28.77 9.96 67 456234 18385 55817381
Second primary malignancy 28.69 9.96 12 456289 7390 55828376
Localised infection 28.57 9.96 344 455957 27068 55808698
Obstructive airways disorder 28.38 9.96 61 456240 17221 55818545
Device use error 28.33 9.96 5 456296 5451 55830315
Agranulocytosis 28.08 9.96 92 456209 22567 55813199
Femur fracture 27.98 9.96 461 455840 38834 55796932
Heart rate decreased 27.95 9.96 472 455829 39955 55795811
Transplant rejection 27.48 9.96 24 456277 9910 55825856
Stevens-Johnson syndrome 27.41 9.96 93 456208 22570 55813196
Haematotoxicity 27.40 9.96 17 456284 8366 55827400
Toxic skin eruption 27.21 9.96 33 456268 11706 55824060
Ischaemic stroke 27.20 9.96 60 456241 16782 55818984
Depressed mood 26.98 9.96 178 456123 36181 55799585
Small for dates baby 26.86 9.96 76 456225 3454 55832312
Tenosynovitis stenosans 26.84 9.96 63 456238 2551 55833215
Headache 26.80 9.96 4050 452251 554994 55280772
Breast cancer metastatic 26.76 9.96 53 456248 15416 55820350
Asphyxia 26.61 9.96 7 456294 5782 55829984
Febrile bone marrow aplasia 26.55 9.96 10 456291 6562 55829204
Parkinsonism 26.48 9.96 23 456278 9523 55826243
Adverse event 26.31 9.96 611 455690 54765 55781001
Graft versus host disease 26.27 9.96 11 456290 6770 55828996
Atrioventricular block complete 26.20 9.96 14 456287 7480 55828286
Complication associated with device 26.20 9.96 53 456248 15297 55820469
Dyskinesia 26.15 9.96 134 456167 28974 55806792
Mania 26.06 9.96 33 456268 11487 55824279
Paralysis 25.99 9.96 21 456280 9011 55826755
Acute generalised exanthematous pustulosis 25.92 9.96 25 456276 9844 55825922
Blood potassium decreased 25.92 9.96 195 456106 38477 55797289
Fear 25.85 9.96 51 456250 14857 55820909
Injection site pain 25.83 9.96 1179 455122 115939 55719827
Tachypnoea 25.72 9.96 54 456247 15376 55820390
Tenosynovitis 25.59 9.96 181 456120 12280 55823486
Smear cervix abnormal 25.33 9.96 64 456237 2717 55833049
Genital haemorrhage 25.22 9.96 12 456289 6850 55828916
Hallucination, auditory 25.05 9.96 34 456267 11490 55824276
Premature delivery 24.97 9.96 332 455969 26728 55809038
Blood pressure diastolic increased 24.91 9.96 136 456165 8425 55827341
Injection site rash 24.84 9.96 228 456073 16730 55819036
Haematoma 24.65 9.96 155 456146 31864 55803902
Pulmonary tuberculosis 24.51 9.96 86 456215 4390 55831376
Haemorrhage intracranial 24.47 9.96 41 456260 12714 55823052
Fall 24.43 9.96 2531 453770 354979 55480787
Jaundice 24.32 9.96 126 456175 27168 55808598
Hypomagnesaemia 24.30 9.96 112 456189 24903 55810863
Brain oedema 24.24 9.96 44 456257 13227 55822539
Neurotoxicity 24.11 9.96 58 456243 15737 55820029
Arthritis infective 24.09 9.96 104 456197 5852 55829914
Panic attack 23.99 9.96 85 456216 20362 55815404
Complication of device insertion 23.97 9.96 11 456290 6413 55829353
Crying 23.92 9.96 91 456210 21349 55814417
Angina pectoris 23.90 9.96 131 456170 27845 55807921
Myoclonus 23.87 9.96 55 456246 15148 55820618
Cardiac failure acute 23.87 9.96 22 456279 8851 55826915
Substance abuse 23.82 9.96 4 456297 4521 55831245
Maternal exposure timing unspecified 23.73 9.96 97 456204 5326 55830440
Bradyphrenia 23.69 9.96 12 456289 6608 55829158
Acute graft versus host disease 23.57 9.96 3 456298 4172 55831594
Dysmorphism 23.45 9.96 54 456247 2159 55833607
Tumour lysis syndrome 23.33 9.96 18 456283 7905 55827861
Wheelchair user 23.32 9.96 97 456204 5369 55830397
Erythema multiforme 23.07 9.96 26 456275 9528 55826238
Cytopenia 23.06 9.96 27 456274 9728 55826038
Aphasia 23.03 9.96 148 456153 30267 55805499
Anhedonia 22.84 9.96 28 456273 9886 55825880
Injection site bruising 22.83 9.96 439 455862 38082 55797684
Breast cancer stage I 22.74 9.96 11 456290 6219 55829547
Tardive dyskinesia 22.70 9.96 19 456282 8012 55827754
Synovial cyst 22.66 9.96 140 456161 9074 55826692
Nervousness 22.58 9.96 140 456161 28875 55806891
Skin ulcer 22.55 9.96 439 455862 38169 55797597
Pulmonary congestion 22.43 9.96 62 456239 16053 55819713
Lethargy 22.42 9.96 288 456013 51153 55784613
Hypomania 22.39 9.96 6 456295 4896 55830870
Pain in extremity 22.39 9.96 2746 453555 294685 55541081
Developmental hip dysplasia 22.34 9.96 39 456262 1272 55834494
Hallucination, visual 22.29 9.96 70 456231 17398 55818368
Unevaluable event 22.28 9.96 263 456038 47424 55788342
Metastases to lung 22.18 9.96 38 456263 11680 55824086
Haemophagocytic lymphohistiocytosis 22.09 9.96 27 456274 9545 55826221
Miosis 22.06 9.96 13 456288 6579 55829187
Cholecystitis chronic 21.97 9.96 28 456273 9720 55826046
Aspergillus infection 21.93 9.96 17 456284 7448 55828318
Skin papilloma 21.83 9.96 83 456218 4406 55831360
Rash maculo-papular 21.71 9.96 141 456160 28766 55807000
Pemphigoid 21.69 9.96 12 456289 6288 55829478
Aggression 21.69 9.96 98 456203 21908 55813858
Neck mass 21.64 9.96 69 456232 3351 55832415
Oedema peripheral 21.59 9.96 1151 455150 170103 55665663
Metastases to central nervous system 21.49 9.96 41 456260 12095 55823671
Dislocation of vertebra 21.48 9.96 94 456207 5321 55830445
Body temperature decreased 21.46 9.96 233 456068 17875 55817891
Synovial fluid analysis 21.32 9.96 48 456253 1890 55833876
Proteinuria 21.31 9.96 72 456229 17498 55818268
Retinitis 21.29 9.96 79 456222 4145 55831621
Red blood cell sedimentation rate 21.24 9.96 80 456221 4228 55831538
Gastroenteritis viral 21.15 9.96 256 456045 20168 55815598
Tubulointerstitial nephritis 21.11 9.96 67 456234 16598 55819168
Rotator cuff repair 21.01 9.96 47 456254 1843 55833923
Malaise 20.89 9.96 2637 453664 365223 55470543
Haemoptysis 20.75 9.96 128 456173 26432 55809334
Loose body in joint 20.74 9.96 37 456264 1228 55834538
Placental disorder 20.69 9.96 40 456261 1413 55834353
Personality disorder 20.68 9.96 8 456293 5165 55830601
Ketoacidosis 20.59 9.96 4 456297 4071 55831695
Diabetes mellitus 20.56 9.96 302 455999 52433 55783333
Leukocytosis 20.54 9.96 111 456190 23680 55812086
Dry skin 20.43 9.96 264 456037 46845 55788921
Myocarditis 20.43 9.96 25 456276 8833 55826933
Cyanosis 20.42 9.96 63 456238 15747 55820019
Skin exfoliation 20.27 9.96 196 456105 36704 55799062
Uterine perforation 20.17 9.96 14 456287 6491 55829275
Hypophagia 20.12 9.96 144 456157 28732 55807034
Hyperlipidaemia 20.12 9.96 77 456224 18032 55817734
Muscle twitching 20.09 9.96 66 456235 16176 55819590
Urinary retention 20.05 9.96 139 456162 27935 55807831
Generalised oedema 20.03 9.96 56 456245 14445 55821321
Multiple allergies 19.90 9.96 34 456267 10462 55825304
Peripheral venous disease 19.89 9.96 145 456156 9934 55825832
Hypermethioninaemia 19.87 9.96 7 456294 12 55835754
Infusion site pain 19.87 9.96 52 456249 13710 55822056
Pathogen resistance 19.84 9.96 12 456289 5988 55829778
Lip swelling 19.81 9.96 128 456173 26144 55809622
Swollen tongue 19.81 9.96 154 456147 30170 55805596
Therapeutic response decreased 19.76 9.96 564 455737 52194 55783572
Polyhydramnios 19.60 9.96 49 456252 2066 55833700
Abdominal distension 19.59 9.96 479 455822 77147 55758619
Product adhesion issue 19.53 9.96 6 456295 4477 55831289
Device related infection 19.50 9.96 101 456200 21779 55813987
Cerebral infarction 19.43 9.96 105 456196 22400 55813366
Temperature regulation disorder 19.43 9.96 6 456295 4462 55831304
Pancreatitis 19.42 9.96 253 456048 44827 55790939
Bronchopulmonary aspergillosis 19.40 9.96 23 456278 8241 55827525
Mobility decreased 19.39 9.96 985 455316 98006 55737760
Psychomotor hyperactivity 19.37 9.96 31 456270 9789 55825977
Atrial septal defect 19.36 9.96 104 456197 6402 55829364
Immune reconstitution inflammatory syndrome 19.26 9.96 11 456290 5663 55830103
Acidosis 19.02 9.96 35 456266 10466 55825300
Exostosis 18.98 9.96 195 456106 14748 55821018
Urinary incontinence 18.97 9.96 151 456150 29434 55806332
Delusion 18.91 9.96 39 456262 11176 55824590
Myelosuppression 18.89 9.96 75 456226 17380 55818386
Klebsiella infection 18.84 9.96 21 456280 7735 55828031
Eating disorder 18.83 9.96 73 456228 17032 55818734
Blood glucose decreased 18.81 9.96 85 456216 19002 55816764
Cardiomyopathy 18.80 9.96 68 456233 16190 55819576
Subdural haematoma 18.74 9.96 52 456249 13447 55822319
Incorrect route of product administration 18.70 9.96 99 456202 21230 55814536
Sinus tachycardia 18.68 9.96 106 456195 22338 55813428
Glycosylated haemoglobin increased 18.68 9.96 39 456262 11126 55824640
Atrioventricular block 18.61 9.96 17 456284 6870 55828896
Catheter site erythema 18.56 9.96 5 456296 4065 55831701
Renal injury 18.54 9.96 27 456274 8860 55826906
Mental disorder 18.31 9.96 114 456187 23490 55812276
Malignant melanoma 18.25 9.96 149 456152 10570 55825196
Acute myocardial infarction 18.19 9.96 158 456143 30235 55805531
Oropharyngeal pain 18.15 9.96 842 455459 82946 55752820
Sleep apnoea syndrome 18.14 9.96 130 456171 25931 55809835
Presyncope 18.11 9.96 127 456174 25455 55810311
Muscular weakness 18.08 9.96 678 455623 103774 55731992
Lip dry 18.02 9.96 138 456163 9602 55826164
Right ventricular failure 17.96 9.96 70 456231 16309 55819457
Complication of device removal 17.95 9.96 7 456294 4497 55831269
Acute chest syndrome 17.94 9.96 25 456276 668 55835098
Colitis 17.88 9.96 235 456066 41576 55794190
Hypophosphataemia 17.87 9.96 32 456269 9670 55826096
Body height below normal 17.85 9.96 46 456255 1977 55833789
Exposure to toxic agent 17.78 9.96 4 456297 3674 55832092
General physical health deterioration 17.64 9.96 1604 454697 168406 55667360
Infusion site swelling 17.60 9.96 23 456278 7898 55827868
Coronary artery disease 17.59 9.96 162 456139 30634 55805132
Vitamin B6 increased 17.52 9.96 6 456295 9 55835757
Infusion site erythema 17.41 9.96 32 456269 9574 55826192
Spinal stenosis 17.39 9.96 182 456119 13832 55821934
Synovial disorder 17.33 9.96 32 456269 1091 55834675
Labelled drug-drug interaction medication error 17.33 9.96 43 456258 11543 55824223
Anuria 17.31 9.96 44 456257 11716 55824050
Pericardial effusion 17.29 9.96 139 456162 27036 55808730
Pyrexia 17.28 9.96 3059 453242 415714 55420052
Oliguria 17.26 9.96 26 456275 8414 55827352
Hereditary angioedema 17.17 9.96 18 456283 6817 55828949
Facet joint syndrome 17.11 9.96 103 456198 6614 55829152
Chills 17.10 9.96 669 455632 101935 55733831
Pseudomonas infection 17.00 9.96 35 456266 10036 55825730
Clostridium difficile colitis 16.98 9.96 86 456215 18652 55817114
Circulatory collapse 16.91 9.96 99 456202 20704 55815062
Foetal anticonvulsant syndrome 16.89 9.96 22 456279 550 55835216
Malignant mediastinal neoplasm 16.84 9.96 28 456273 877 55834889
Congenital arterial malformation 16.81 9.96 17 456284 320 55835446
Hot flush 16.71 9.96 272 456029 46454 55789312
Polyuria 16.70 9.96 22 456279 7529 55828237
Hyperthyroidism 16.69 9.96 54 456247 13298 55822468
Joint noise 16.62 9.96 68 456233 3736 55832030
Dementia 16.56 9.96 77 456224 17081 55818685
Bradypnoea 16.49 9.96 3 456298 3200 55832566
Hepatotoxicity 16.48 9.96 167 456134 30986 55804780
Dystonia 16.40 9.96 49 456252 12372 55823394
Lymphocyte count decreased 16.38 9.96 146 456155 27793 55807973
Colitis microscopic 16.36 9.96 24 456277 7851 55827915
Haemorrhage in pregnancy 16.31 9.96 41 456260 1735 55834031
Mouth ulceration 16.30 9.96 334 455967 29306 55806460
Product substitution issue 16.26 9.96 62 456239 14537 55821229
Hypothyroidism 16.22 9.96 215 456086 37981 55797785
Wound infection 15.98 9.96 191 456110 15002 55820764
Paranoia 15.97 9.96 40 456261 10704 55825062
Purpura 15.86 9.96 38 456263 10324 55825442
Hyperprolactinaemia 15.77 9.96 5 456296 3656 55832110
Device breakage 15.70 9.96 37 456264 10110 55825656
Clear cell renal cell carcinoma 15.63 9.96 33 456268 1243 55834523
Dermatitis atopic 15.63 9.96 27 456274 8272 55827494
Rash erythematous 15.62 9.96 210 456091 37011 55798755
Visual acuity reduced 15.61 9.96 101 456200 20625 55815141
Postoperative wound infection 15.61 9.96 129 456172 9184 55826582
Cushingoid 15.60 9.96 108 456193 7276 55828490
Shock haemorrhagic 15.58 9.96 31 456270 9002 55826764
Rhinitis allergic 15.57 9.96 28 456273 8446 55827320
Body temperature increased 15.56 9.96 190 456111 34052 55801714
Foetal death 15.52 9.96 121 456180 8466 55827300
Adjustment disorder with depressed mood 15.48 9.96 82 456219 5021 55830745
Cough 15.43 9.96 1858 454443 258103 55577663
Product preparation error 15.42 9.96 10 456291 4806 55830960
Breast feeding 15.42 9.96 26 456275 824 55834942
Fear of injection 15.40 9.96 98 456203 6417 55829349
Injection site warmth 15.39 9.96 180 456121 14063 55821703
Fracture delayed union 15.37 9.96 48 456253 2305 55833461
Dysuria 15.33 9.96 167 456134 30562 55805204
Rectal haemorrhage 15.29 9.96 240 456061 41227 55794539
Epstein-Barr virus infection 15.25 9.96 23 456278 7440 55828326
Respiration abnormal 15.16 9.96 14 456287 5627 55830139
Salivary hypersecretion 15.13 9.96 21 456280 7029 55828737
Potentiating drug interaction 15.11 9.96 7 456294 4059 55831707
Product complaint 15.09 9.96 47 456254 11713 55824053
Talipes 15.08 9.96 35 456266 1407 55834359
Anti-cyclic citrullinated peptide antibody 15.05 9.96 65 456236 3658 55832108
Pulseless electrical activity 14.99 9.96 21 456280 7003 55828763
Aspiration 14.95 9.96 35 456266 9586 55826180
Progressive multifocal leukoencephalopathy 14.73 9.96 49 456252 11964 55823802
Epilepsy 14.73 9.96 132 456169 25099 55810667
Blood loss anaemia 14.72 9.96 28 456273 8269 55827497
Status epilepticus 14.58 9.96 68 456233 15073 55820693
Troponin increased 14.58 9.96 30 456271 8605 55827161
Treatment noncompliance 14.45 9.96 182 456119 32441 55803325
Obesity 14.40 9.96 259 456042 22189 55813577
Scleritis 14.40 9.96 64 456237 3647 55832119
Abortion missed 14.40 9.96 37 456264 1587 55834179
Stillbirth 14.40 9.96 93 456208 6121 55829645
Exomphalos 14.39 9.96 20 456281 533 55835233
Hemiplegia 14.36 9.96 29 456272 8375 55827391
Renal disorder 14.33 9.96 162 456139 29443 55806323
Sinus bradycardia 14.31 9.96 59 456242 13527 55822239
Cardiotoxicity 14.30 9.96 25 456276 7625 55828141
Tendonitis 14.28 9.96 216 456085 17881 55817885
Human antichimeric antibody positive 14.27 9.96 36 456265 1527 55834239
Head injury 14.26 9.96 132 456169 24934 55810832
Laryngospasm 14.22 9.96 3 456298 2881 55832885
Gestational hypertension 14.20 9.96 46 456255 2253 55833513
Epistaxis 14.19 9.96 424 455877 66599 55769167
Injection site haematoma 14.14 9.96 93 456208 6159 55829607
Hepatitis acute 14.14 9.96 29 456272 8328 55827438
Renal tubular necrosis 14.09 9.96 43 456258 10785 55824981
Mood altered 14.06 9.96 58 456243 13297 55822469
Drug abuser 14.04 9.96 3 456298 2856 55832910
Abdominal pain upper 14.03 9.96 1249 455052 177064 55658702
Dactylitis 13.97 9.96 43 456258 2049 55833717
Induced labour 13.95 9.96 26 456275 893 55834873
Visual impairment 13.89 9.96 477 455824 73725 55762041
Rebound effect 13.87 9.96 7 456294 3863 55831903
Cholestasis of pregnancy 13.84 9.96 30 456271 1151 55834615
Pneumonia viral 13.74 9.96 23 456278 7135 55828631
Hepatic cytolysis 13.71 9.96 44 456257 10862 55824904
Transplant dysfunction 13.70 9.96 11 456290 4735 55831031
Catheter site pain 13.63 9.96 9 456292 4284 55831482
Bundle branch block left 13.60 9.96 19 456282 6343 55829423
Respiratory acidosis 13.58 9.96 18 456283 6145 55829621
Pharyngitis streptococcal 13.56 9.96 127 456174 9371 55826395
Myopathy 13.47 9.96 38 456263 9774 55825992
Neonatal respiratory distress syndrome 13.46 9.96 51 456250 2703 55833063
Mucormycosis 13.44 9.96 3 456298 2771 55832995
Cytomegalovirus viraemia 13.41 9.96 13 456288 5107 55830659
Sleep disorder due to a general medical condition 13.39 9.96 34 456267 9056 55826710
Off label use 13.31 9.96 4168 452133 552012 55283754
Bursitis 13.30 9.96 305 455996 27277 55808489
Ankylosing spondylitis 13.30 9.96 131 456170 9799 55825967
Blood iron increased 13.27 9.96 33 456268 1387 55834379
Antinuclear antibody positive 13.26 9.96 98 456203 6743 55829023
Neutropenic colitis 13.23 9.96 3 456298 2740 55833026
Bone marrow failure 13.21 9.96 156 456145 28130 55807636
Immunodeficiency 13.20 9.96 194 456107 15963 55819803
Middle insomnia 13.20 9.96 45 456256 10905 55824861
Systemic inflammatory response syndrome 13.15 9.96 14 456287 5264 55830502
Acute respiratory distress syndrome 13.11 9.96 114 456187 21812 55813954
Skin cancer 13.09 9.96 135 456166 10220 55825546
Chronic graft versus host disease 13.08 9.96 5 456296 3251 55832515
Fracture 13.05 9.96 212 456089 17806 55817960
Embedded device 13.05 9.96 4 456297 2989 55832777
Cervical incompetence 13.04 9.96 20 456281 584 55835182
Food allergy 13.00 9.96 33 456268 8791 55826975
Device issue 12.95 9.96 109 456192 20997 55814769
Polydipsia 12.94 9.96 5 456296 3230 55832536
Infusion site pruritus 12.83 9.96 12 456289 4795 55830971
Pulmonary haemorrhage 12.83 9.96 22 456279 6761 55829005
Drug screen positive 12.82 9.96 6 456295 3458 55832308
Muscle rigidity 12.76 9.96 44 456257 10627 55825139
Haemodialysis 12.76 9.96 32 456269 8559 55827207
Affective disorder 12.73 9.96 16 456285 5587 55830179
Inadequate analgesia 12.72 9.96 3 456298 2668 55833098
Antibody test positive 12.70 9.96 46 456255 2385 55833381
Poor venous access 12.63 9.96 154 456147 12152 55823614
Colorectal cancer 12.60 9.96 6 456295 3423 55832343
Acute coronary syndrome 12.56 9.96 39 456262 9729 55826037
Chronic obstructive pulmonary disease 12.46 9.96 362 455939 57053 55778713
Trigeminal neuralgia 12.46 9.96 6 456295 3401 55832365
Cardiac disorder 12.45 9.96 280 456021 45607 55790159
Ear infection 12.40 9.96 337 455964 30958 55804808
Oxygen consumption increased 12.38 9.96 7 456294 3624 55832142
Speech disorder developmental 12.36 9.96 20 456281 612 55835154
Taste disorder 12.35 9.96 39 456262 9676 55826090
Sexual dysfunction 12.34 9.96 6 456295 3382 55832384
Tongue disorder 12.29 9.96 130 456171 9906 55825860
Abortion incomplete 12.23 9.96 5 456296 3122 55832644
Atrial flutter 12.23 9.96 36 456265 9133 55826633
Lymphoedema 12.20 9.96 44 456257 10486 55825280
Dermatitis exfoliative 12.17 9.96 15 456286 5284 55830482
Pulmonary alveolar haemorrhage 12.16 9.96 10 456291 4254 55831512
Somnambulism 12.14 9.96 14 456287 5078 55830688
Therapy change 12.13 9.96 16 456285 5472 55830294
Joint lock 12.12 9.96 42 456259 2130 55833636
Foetal distress syndrome 12.08 9.96 30 456271 1260 55834506
Hyperuricaemia 12.04 9.96 14 456287 5059 55830707
Eosinophil count increased 12.03 9.96 39 456262 9598 55826168
Product prescribing error 11.97 9.96 125 456176 23061 55812705
Catheter management 11.93 9.96 4 456297 2822 55832944
Prescribed underdose 11.89 9.96 234 456067 20383 55815383
Hallucinations, mixed 11.86 9.96 11 456290 4413 55831353
Bone lesion 11.83 9.96 16 456285 5414 55830352
Blood urea increased 11.81 9.96 134 456167 24339 55811427
Pregnancy with contraceptive device 11.79 9.96 10 456291 4189 55831577
Multiple drug therapy 11.70 9.96 4 456297 2788 55832978
Catatonia 11.68 9.96 9 456292 3955 55831811
Autism spectrum disorder 11.68 9.96 22 456279 762 55835004
Human anti-human antibody test 11.67 9.96 16 456285 421 55835345
Squamous cell carcinoma 11.66 9.96 109 456192 8039 55827727
Vascular device infection 11.65 9.96 17 456284 5573 55830193
Lymphatic fistula 11.64 9.96 22 456279 764 55835002
Immunosuppression 11.63 9.96 107 456194 7857 55827909
Amylase increased 11.59 9.96 18 456283 5753 55830013
Product physical issue 11.58 9.96 12 456289 4570 55831196
Breast cancer female 11.54 9.96 56 456245 12282 55823484
Breast cancer stage II 11.52 9.96 18 456283 5740 55830026
Toxic encephalopathy 11.47 9.96 19 456282 5919 55829847
Cyst 11.47 9.96 156 456145 12622 55823144
Haematemesis 11.45 9.96 164 456137 28594 55807172
Application site pain 11.42 9.96 9 456292 3911 55831855
Foot fracture 11.42 9.96 244 456057 21565 55814201
Procedural pain 11.41 9.96 81 456220 16190 55819576
Bundle branch block right 11.37 9.96 13 456288 4734 55831032
Herpes zoster 11.36 9.96 737 455564 75152 55760614
Femoral hernia incarcerated 11.34 9.96 22 456279 779 55834987
Maternal exposure during breast feeding 11.33 9.96 59 456242 3588 55832178
Rheumatoid lung 11.33 9.96 53 456248 3087 55832679
Hypertelorism 11.30 9.96 16 456285 434 55835332
Embolism 11.27 9.96 27 456274 7337 55828429
Joint injury 11.25 9.96 280 456021 25374 55810392
Hepatic necrosis 11.24 9.96 16 456285 5300 55830466
Hypernatraemia 11.18 9.96 23 456278 6597 55829169
Diabetes insipidus 11.10 9.96 3 456298 2434 55833332
Forceps delivery 11.10 9.96 11 456290 202 55835564
Occult blood 11.08 9.96 28 456273 1189 55834577
Extra dose administered 11.06 9.96 17 456284 5456 55830310
Blood parathyroid hormone decreased 11.03 9.96 110 456191 8254 55827512
Bone density abnormal 11.03 9.96 54 456247 3205 55832561
Adenovirus infection 11.02 9.96 7 456294 3401 55832365
Onychomycosis 11.00 9.96 91 456210 6481 55829285
Incoherent 11.00 9.96 11 456290 4258 55831508
Device deployment issue 10.97 9.96 8 456293 3616 55832150
Deep vein thrombosis postoperative 10.96 9.96 63 456238 3978 55831788
Dialysis 10.94 9.96 41 456260 9661 55826105
Sickle cell anaemia 10.94 9.96 18 456283 559 55835207
Nystagmus 10.92 9.96 19 456282 5806 55829960
Ileus 10.79 9.96 67 456234 13815 55821951
Incorrect product administration duration 10.78 9.96 45 456256 10281 55825485
Wound infection pseudomonas 10.69 9.96 29 456272 1286 55834480
Pancreatic steatosis 10.68 9.96 24 456277 944 55834822
Eyelid haemangioma 10.65 9.96 4 456297 9 55835757
Ulcer 10.65 9.96 248 456053 22237 55813529
Affect lability 10.64 9.96 44 456257 10081 55825685
Hypoglycaemic coma 10.62 9.96 3 456298 2364 55833402
Joint warmth 10.61 9.96 31 456270 1435 55834331
Anterior chamber cleavage syndrome 10.52 9.96 10 456291 174 55835592
Blood sodium decreased 10.50 9.96 123 456178 22211 55813555
Nail injury 10.47 9.96 17 456284 522 55835244
Intervertebral disc degeneration 10.43 9.96 168 456133 14086 55821680
Granuloma skin 10.43 9.96 95 456206 6956 55828810
Oral herpes 10.39 9.96 251 456050 22639 55813127
Bone disorder 10.34 9.96 219 456082 19324 55816442
Ear pain 10.34 9.96 182 456119 30708 55805058
Anti-neutrophil cytoplasmic antibody positive vasculitis 10.32 9.96 4 456297 2579 55833187
Hyperammonaemia 10.32 9.96 15 456286 4925 55830841
Tendon disorder 10.31 9.96 78 456223 5407 55830359
Knee operation 10.28 9.96 76 456225 5229 55830537
Prescribed overdose 10.28 9.96 245 456056 22051 55813715
Wrong product administered 10.19 9.96 19 456282 5653 55830113
Endodontic procedure 10.19 9.96 49 456252 2887 55832879
Abortion threatened 10.14 9.96 17 456284 536 55835230
Upper respiratory tract irritation 10.13 9.96 8 456293 107 55835659
Hypertransaminasaemia 10.12 9.96 14 456287 4693 55831073
Abnormal dreams 10.10 9.96 42 456259 9607 55826159
Electrocardiogram QRS complex prolonged 10.10 9.96 18 456283 5449 55830317
Paraesthesia oral 10.09 9.96 72 456229 14377 55821389
Lipase increased 10.09 9.96 38 456263 8941 55826825
Erythema 10.08 9.96 1108 455193 154831 55680935
Disseminated tuberculosis 10.06 9.96 47 456254 2736 55833030
Tinnitus 10.05 9.96 177 456124 29865 55805901
Lymphadenectomy 10.05 9.96 23 456278 916 55834850
Mycobacterium tuberculosis complex test positive 10.04 9.96 37 456264 1935 55833831
Retrognathia 10.04 9.96 15 456286 428 55835338
Catheter site haemorrhage 10.03 9.96 6 456295 3012 55832754
Acute pulmonary oedema 10.01 9.96 30 456271 7567 55828199
Metastases to lymph nodes 10.01 9.96 29 456272 7394 55828372
Motor dysfunction 10.00 9.96 41 456260 9416 55826350
Plasma cell myeloma recurrent 9.97 9.96 5 456296 2769 55832997

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Rheumatoid arthritis 452.30 10.20 843 159582 46966 31489953
Drug abuse 339.31 10.20 28 160397 87730 31449189
Foetal exposure during pregnancy 321.37 10.20 667 159758 40209 31496710
Completed suicide 241.39 10.20 81 160344 91433 31445486
Toxicity to various agents 239.69 10.20 342 160083 181145 31355774
Arthralgia 223.48 10.20 1420 159005 150004 31386915
Psoriatic arthropathy 147.52 10.20 317 160108 19566 31517353
Dysmorphism 128.70 10.20 114 160311 2958 31533961
Drug interaction 117.80 10.20 599 159826 207944 31328975
Joint swelling 110.42 10.20 549 159876 52882 31484037
Sickle cell anaemia with crisis 110.24 10.20 102 160323 2805 31534114
Intentional overdose 101.69 10.20 41 160384 41348 31495571
Musculoskeletal stiffness 96.55 10.20 440 159985 40885 31496034
Premature baby 96.01 10.20 253 160172 17813 31519106
Enthesopathy 82.28 10.20 105 160320 4182 31532737
Acute kidney injury 74.71 10.20 983 159442 278731 31258188
Tenosynovitis 74.40 10.20 99 160326 4111 31532808
Exposure during pregnancy 74.28 10.20 146 160279 8452 31528467
Death 72.09 10.20 1339 159086 359230 31177689
Blood pressure fluctuation 72.04 10.20 266 160159 22470 31514449
Neonatal respiratory distress syndrome 71.19 10.20 93 160332 3792 31533127
Speech disorder developmental 70.96 10.20 69 160356 2022 31534897
Appendicolith 69.70 10.20 113 160312 5618 31531301
Product use in unapproved indication 67.84 10.20 265 160160 98906 31438013
Hypospadias 65.69 10.20 80 160345 3036 31533883
Synovitis 65.25 10.20 172 160253 12111 31524808
Atrial septal defect 63.97 10.20 121 160304 6806 31530113
Pain 61.87 10.20 1306 159119 185453 31351466
Foetal anticonvulsant syndrome 60.51 10.20 49 160376 1120 31535799
Suicide attempt 59.88 10.20 60 160365 37188 31499731
Nasopharyngitis 58.51 10.20 532 159893 62713 31474206
Febrile neutropenia 58.38 10.20 369 160056 121480 31415439
Serotonin syndrome 58.21 10.20 12 160413 18761 31518158
Overdose 56.77 10.20 228 160197 84436 31452483
Rhabdomyolysis 56.63 10.20 151 160274 63430 31473489
Drug reaction with eosinophilia and systemic symptoms 54.69 10.20 43 160382 29975 31506944
C-reactive protein abnormal 54.35 10.20 121 160304 7648 31529271
Maternal exposure during pregnancy 54.18 10.20 90 160335 4566 31532353
Cryptorchism 53.69 10.20 58 160367 1929 31534990
Blood pressure systolic increased 53.68 10.20 218 160207 19252 31517667
Maternal drugs affecting foetus 53.07 10.20 81 160344 3822 31533097
Small for dates baby 52.75 10.20 78 160347 3577 31533342
Autism spectrum disorder 52.31 10.20 60 160365 2135 31534784
Arthropathy 51.70 10.20 250 160175 23801 31513118
Hypoglycaemia neonatal 49.89 10.20 53 160372 1729 31535190
Coma 49.88 10.20 82 160343 41068 31495851
Drug dependence 49.81 10.20 26 160399 22553 31514366
Arthritis 49.37 10.20 271 160154 27114 31509805
Tuberculosis 48.65 10.20 121 160304 8220 31528699
Low birth weight baby 48.14 10.20 108 160317 6862 31530057
Learning disorder 47.89 10.20 41 160384 1015 31535904
Maternal exposure during breast feeding 46.82 10.20 48 160377 1501 31535418
Appendicitis 46.77 10.20 146 160279 11319 31525600
Alanine aminotransferase abnormal 46.59 10.20 77 160348 3890 31533029
Hepatic function abnormal 45.58 10.20 87 160338 41135 31495784
Syndactyly 44.23 10.20 36 160389 829 31536090
Ventricular septal defect 44.03 10.20 72 160353 3605 31533314
Tongue disorder 43.10 10.20 85 160340 4932 31531987
Rheumatoid nodule 42.77 10.20 60 160365 2621 31534298
Angioedema 41.68 10.20 66 160359 33552 31503367
Respiratory arrest 41.40 10.20 43 160382 26214 31510705
Developmental delay 41.11 10.20 58 160367 2547 31534372
Cardiac failure 40.27 10.20 262 160163 85691 31451228
Foot deformity 40.22 10.20 74 160351 4075 31532844
Blood pressure diastolic abnormal 39.88 10.20 72 160353 3907 31533012
Psoriasis 39.70 10.20 386 160039 46333 31490586
Haemoglobin decreased 39.22 10.20 794 159631 111881 31425038
Jaundice neonatal 38.78 10.20 40 160385 1260 31535659
Renal failure 38.72 10.20 418 160007 122912 31414007
Bradycardia 38.52 10.20 200 160225 69127 31467792
Basal cell carcinoma 38.38 10.20 188 160237 17991 31518928
Drug resistance 37.44 10.20 38 160387 23415 31513504
Infusion related reaction 36.03 10.20 387 160038 47668 31489251
Pulmonary fibrosis 35.68 10.20 173 160252 16487 31520432
Lower respiratory tract infection 35.61 10.20 255 160170 27982 31508937
Drug intolerance 35.36 10.20 411 160014 51622 31485297
Blood pressure systolic abnormal 35.03 10.20 59 160366 3028 31533891
Exposure via breast milk 34.82 10.20 45 160380 1815 31535104
Joint laxity 34.35 10.20 23 160402 388 31536531
Delirium 34.19 10.20 102 160323 41319 31495600
Drug withdrawal syndrome 33.97 10.20 27 160398 18723 31518196
Disease progression 33.70 10.20 294 160131 90170 31446749
Talipes 33.53 10.20 44 160381 1802 31535117
Osteoarthritis 33.24 10.20 187 160238 18880 31518039
Peripheral swelling 32.82 10.20 504 159921 67361 31469558
Palmar-plantar erythrodysaesthesia syndrome 32.45 10.20 19 160406 15464 31521455
Pain in extremity 31.97 10.20 792 159633 115411 31421508
Blood pressure diastolic decreased 31.73 10.20 101 160324 7912 31529007
Intellectual disability 31.69 10.20 35 160390 1194 31535725
Hand deformity 31.64 10.20 56 160369 2991 31533928
Tendonitis 31.30 10.20 105 160320 8453 31528466
Suicidal ideation 31.25 10.20 88 160337 36318 31500601
C-reactive protein increased 31.17 10.20 380 160045 48270 31488649
Congenital hand malformation 31.11 10.20 25 160400 565 31536354
Cytomegalovirus infection 31.11 10.20 48 160377 24659 31512260
Pancytopenia 30.27 10.20 615 159810 86701 31450218
Intentional product misuse 30.22 10.20 95 160330 37856 31499063
Hypermobility syndrome 29.74 10.20 20 160405 340 31536579
Cardiac arrest 29.51 10.20 298 160127 88764 31448155
Joint effusion 29.26 10.20 69 160356 4530 31532389
Plagiocephaly 29.03 10.20 23 160402 509 31536410
Heart rate decreased 28.83 10.20 243 160182 28023 31508896
Language disorder 28.78 10.20 44 160381 2079 31534840
Astigmatism 28.72 10.20 31 160394 1030 31535889
Blood pressure increased 28.64 10.20 564 159861 79069 31457850
Foetal growth restriction 28.48 10.20 61 160364 3754 31533165
Poisoning 27.71 10.20 9 160416 10382 31526537
Altered state of consciousness 27.37 10.20 40 160385 21011 31515908
Polyarthritis 27.28 10.20 64 160361 4188 31532731
Body temperature decreased 27.23 10.20 125 160300 11645 31525274
Agitation 26.97 10.20 162 160263 54007 31482912
Hypoglycaemia 26.62 10.20 150 160275 50796 31486123
Dysgraphia 26.49 10.20 43 160382 2140 31534779
Toxic epidermal necrolysis 26.48 10.20 36 160389 19488 31517431
Pathogen resistance 26.08 10.20 6 160419 8695 31528224
Large for dates baby 25.86 10.20 27 160398 863 31536056
Substance abuse 25.76 10.20 3 160422 7155 31529764
Shock 25.73 10.20 47 160378 22598 31514321
Blood creatine phosphokinase increased 25.68 10.20 117 160308 41857 31495062
Knee arthroplasty 25.36 10.20 82 160343 6476 31530443
Selective eating disorder 25.25 10.20 37 160388 1683 31535236
Neuroleptic malignant syndrome 25.07 10.20 29 160396 16840 31520079
Hypotonia neonatal 25.02 10.20 32 160393 1277 31535642
Anticonvulsant drug level above therapeutic 24.99 10.20 23 160402 628 31536291
Scoliosis 24.75 10.20 46 160379 2553 31534366
Motor developmental delay 24.72 10.20 23 160402 637 31536282
Knee deformity 24.54 10.20 22 160403 580 31536339
Rash maculo-papular 24.50 10.20 59 160366 25660 31511259
Somnolence 24.45 10.20 355 160070 99090 31437829
Hyperbilirubinaemia neonatal 24.27 10.20 24 160401 718 31536201
Urticaria 24.13 10.20 181 160244 57336 31479583
Hyperglycaemia 23.94 10.20 99 160326 36377 31500542
Sedation 23.73 10.20 37 160388 18928 31517991
Inflammation 23.66 10.20 213 160212 25028 31511891
Stress 23.14 10.20 210 160215 24731 31512188
Serum ferritin increased 22.92 10.20 73 160352 5719 31531200
General physical health deterioration 22.29 10.20 741 159684 112694 31424225
Musculoskeletal pain 22.25 10.20 240 160185 29588 31507331
Otitis media 22.09 10.20 44 160381 2572 31534347
Neck mass 22.03 10.20 33 160392 1531 31535388
Renal impairment 22.02 10.20 306 160119 86043 31450876
Caesarean section 21.96 10.20 37 160388 1899 31535020
Red blood cell sedimentation rate increased 21.86 10.20 92 160333 8254 31528665
Depressed level of consciousness 21.64 10.20 111 160314 38490 31498429
Lactic acidosis 21.39 10.20 86 160339 31851 31505068
Low set ears 21.32 10.20 18 160407 437 31536482
Malignant neoplasm progression 21.21 10.20 277 160148 78721 31458198
Pulmonary tuberculosis 21.10 10.20 62 160363 4649 31532270
Nasal disorder 20.81 10.20 34 160391 1701 31535218
Drug withdrawal syndrome neonatal 20.73 10.20 51 160374 3441 31533478
Grip strength decreased 20.56 10.20 43 160382 2603 31534316
Anal fistula 20.52 10.20 62 160363 4721 31532198
Dyspraxia 20.51 10.20 17 160408 402 31536517
Vitamin B12 deficiency 20.47 10.20 51 160374 3468 31533451
Diaphragmatic disorder 20.42 10.20 27 160398 1114 31535805
Hepatic enzyme increased 20.26 10.20 274 160151 35634 31501285
Strabismus 19.98 10.20 32 160393 1574 31535345
Hypertelorism 19.93 10.20 19 160406 543 31536376
Cleft lip 19.76 10.20 15 160410 311 31536608
Weight decreased 19.48 10.20 993 159432 158959 31377960
Dyslexia 19.44 10.20 15 160410 319 31536600
Excessive eye blinking 19.39 10.20 18 160407 497 31536422
Toxic optic neuropathy 19.33 10.20 22 160403 776 31536143
Joint stiffness 19.30 10.20 101 160324 9920 31526999
Acute hepatic failure 19.23 10.20 22 160403 12837 31524082
Foetal disorder 19.06 10.20 22 160403 788 31536131
Skin cancer 19.06 10.20 96 160329 9289 31527630
Finger deformity 18.93 10.20 27 160398 1198 31535721
Anal atresia 18.83 10.20 14 160411 281 31536638
Blood parathyroid hormone decreased 18.77 10.20 28 160397 1294 31535625
Venoocclusive liver disease 18.77 10.20 7 160418 7405 31529514
Hydrocele 18.76 10.20 35 160390 1948 31534971
Hepatic cyst 18.67 10.20 39 160386 2359 31534560
Intentional self-injury 18.62 10.20 24 160401 13291 31523628
Loss of personal independence in daily activities 18.57 10.20 222 160203 28066 31508853
Vitamin D deficiency 18.45 10.20 69 160356 5863 31531056
Agitation neonatal 18.42 10.20 25 160400 1058 31535861
Medical device implantation 18.36 10.20 19 160406 601 31536318
Hepatic failure 18.35 10.20 94 160331 32608 31504311
Neck pain 18.34 10.20 187 160238 22723 31514196
Behaviour disorder 18.32 10.20 56 160369 4291 31532628
Arthritis bacterial 18.30 10.20 58 160367 4532 31532387
Ear infection 18.14 10.20 91 160334 8790 31528129
Blood pressure diastolic increased 17.97 10.20 55 160370 4218 31532701
Radiation inflammation 17.90 10.20 18 160407 550 31536369
Bradycardia neonatal 17.81 10.20 23 160402 927 31535992
Red blood cell sedimentation rate 17.75 10.20 24 160401 1012 31535907
Lacrimal disorder 17.70 10.20 14 160411 309 31536610
Poor venous access 17.61 10.20 53 160372 4027 31532892
Abdominal distension 17.55 10.20 357 160068 50327 31486592
Congenital bladder anomaly 17.52 10.20 13 160412 260 31536659
Attention deficit hyperactivity disorder 17.51 10.20 38 160387 2360 31534559
Umbilical hernia 17.50 10.20 54 160371 4160 31532759
Limb reduction defect 17.48 10.20 13 160412 261 31536658
Weight decrease neonatal 17.25 10.20 14 160411 321 31536598
Patent ductus arteriosus 17.25 10.20 45 160380 3148 31533771
Stevens-Johnson syndrome 17.23 10.20 39 160386 17333 31519586
Congenital anomaly 17.16 10.20 27 160398 1308 31535611
Spinal disorder 16.99 10.20 51 160374 3869 31533050
Post procedural infection 16.99 10.20 56 160369 4467 31532452
Bronchiolitis 16.80 10.20 42 160383 2862 31534057
Aggression 16.78 10.20 115 160310 37176 31499743
Congenital foot malformation 16.78 10.20 15 160410 394 31536525
Multiple congenital abnormalities 16.65 10.20 17 160408 529 31536390
Respiratory depression 16.59 10.20 30 160395 14480 31522439
Ankyloglossia congenital 16.55 10.20 13 160412 284 31536635
Therapeutic product effect decreased 16.51 10.20 238 160187 31384 31505535
Renal aplasia 16.41 10.20 19 160406 683 31536236
Accessory spleen 16.36 10.20 10 160415 143 31536776
Pyrexia 16.35 10.20 1320 159105 302520 31234399
Respiratory rate increased 16.33 10.20 91 160334 9154 31527765
Haemangioma 16.30 10.20 31 160394 1751 31535168
Ear disorder 16.25 10.20 27 160398 1370 31535549
Respiratory disorder neonatal 16.21 10.20 28 160397 1467 31535452
Granuloma skin 16.13 10.20 24 160401 1107 31535812
Latent tuberculosis 16.08 10.20 25 160400 1199 31535720
Haemangioma congenital 16.06 10.20 16 160409 483 31536436
Microcephaly 16.00 10.20 20 160405 780 31536139
Abdominal pain 15.95 10.20 897 159528 145055 31391864
Cerebral haemorrhage 15.87 10.20 99 160326 32713 31504206
Back disorder 15.83 10.20 67 160358 6026 31530893
Foetal heart rate deceleration abnormality 15.82 10.20 16 160409 492 31536427
Juvenile idiopathic arthritis 15.67 10.20 30 160395 1703 31535216
Asthma 15.63 10.20 139 160286 42472 31494447
Joint range of motion decreased 15.60 10.20 71 160354 6590 31530329
Arthrodesis 15.27 10.20 15 160410 445 31536474
Haematocrit decreased 15.20 10.20 225 160200 29836 31507083
Cholelithiasis 15.12 10.20 158 160267 19321 31517598
Arnold-Chiari malformation 15.08 10.20 13 160412 325 31536594
Infective pulmonary exacerbation of cystic fibrosis 15.00 10.20 7 160418 6477 31530442
Pectus excavatum 15.00 10.20 11 160414 216 31536703
Maternal exposure before pregnancy 14.78 10.20 18 160407 683 31536236
Psychomotor retardation 14.76 10.20 43 160382 3209 31533710
Wound 14.73 10.20 114 160311 12814 31524105
C-reactive protein decreased 14.69 10.20 30 160395 1785 31535134
Hallucination 14.66 10.20 157 160268 46253 31490666
Respiratory failure 14.64 10.20 396 160029 101053 31435866
Foetal distress syndrome 14.60 10.20 22 160403 1026 31535893
Oesophageal fibrosis 14.57 10.20 10 160415 176 31536743
Drug ineffective for unapproved indication 14.54 10.20 44 160381 17746 31519173
Product quality issue 14.53 10.20 38 160387 16073 31520846
Hypotension 14.45 10.20 868 159557 203750 31333169
Wrong technique in product usage process 14.43 10.20 104 160321 33239 31503680
Upper respiratory tract infection 14.40 10.20 219 160206 29203 31507716
Malignant melanoma 14.38 10.20 77 160348 7630 31529289
Tooth malformation 14.33 10.20 10 160415 181 31536738
Mouth ulceration 14.27 10.20 99 160326 10749 31526170
Gastrointestinal infection 14.24 10.20 55 160370 4745 31532174
Second primary malignancy 14.22 10.20 9 160416 7023 31529896
Gaze palsy 14.10 10.20 26 160399 1434 31535485
Septic arthritis staphylococcal 14.00 10.20 15 160410 494 31536425
Microphthalmos 13.96 10.20 10 160415 189 31536730
Aspergillus infection 13.94 10.20 23 160402 11505 31525414
Maternal exposure timing unspecified 13.91 10.20 13 160412 362 31536557
Polydactyly 13.79 10.20 23 160402 1171 31535748
Lung neoplasm malignant 13.73 10.20 134 160291 16096 31520823
Akathisia 13.71 10.20 10 160415 7243 31529676
No adverse event 13.68 10.20 52 160373 19573 31517346
Obsessive-compulsive disorder 13.66 10.20 4 160421 4933 31531986
Pharyngeal disorder 13.66 10.20 17 160408 660 31536259
Progressive multifocal leukoencephalopathy 13.52 10.20 16 160409 9197 31527722
Plasma cell myeloma 13.47 10.20 203 160222 56328 31480591
Unresponsive to stimuli 13.45 10.20 76 160349 25724 31511195
Hepatitis E antibody positive 13.42 10.20 11 160414 256 31536663
Osteonecrosis of jaw 13.40 10.20 43 160382 17028 31519891
Subdural haematoma 13.40 10.20 50 160375 18921 31517998
Localised infection 13.39 10.20 127 160298 15138 31521781
Immune reconstitution inflammatory syndrome 13.34 10.20 13 160412 8165 31528754
Blood albumin decreased 13.28 10.20 108 160317 12323 31524596
Oxygen saturation decreased 13.26 10.20 334 160091 48781 31488138
Back pain 13.25 10.20 679 159746 108734 31428185
Chronic graft versus host disease 13.22 10.20 3 160422 4389 31532530
Hernia pain 13.20 10.20 11 160414 262 31536657
Immunodeficiency 13.19 10.20 53 160372 4656 31532263
Hypertriglyceridaemia 13.18 10.20 12 160413 7786 31529133
Synovial cyst 13.16 10.20 31 160394 2034 31534885
Blood folate decreased 13.09 10.20 17 160408 689 31536230
Oropharyngeal pain 13.05 10.20 228 160197 31255 31505664
Tachycardia 13.03 10.20 290 160135 75917 31461002
Cleft lip and palate 13.00 10.20 14 160411 464 31536455
Sexual dysfunction 12.97 10.20 7 160418 5961 31530958
Crohn's disease 12.87 10.20 48 160377 4073 31532846
Infection 12.86 10.20 522 159903 81409 31455510
Ventricular tachycardia 12.81 10.20 69 160356 23632 31513287
Off label use 12.78 10.20 1551 158874 345723 31191196
Depression 12.71 10.20 356 160069 90459 31446460
Disseminated intravascular coagulation 12.70 10.20 57 160368 20480 31516439
Vascular insufficiency 12.70 10.20 12 160413 339 31536580
Spina bifida 12.61 10.20 12 160413 342 31536577
Diverticular perforation 12.60 10.20 40 160385 3129 31533790
Panniculitis 12.59 10.20 28 160397 1768 31535151
Inguinal hernia 12.55 10.20 69 160356 6906 31530013
Blood insulin increased 12.47 10.20 12 160413 347 31536572
Hepatitis E virus test positive 12.46 10.20 11 160414 284 31536635
Injection site pain 12.34 10.20 245 160180 34389 31502530
Arthritis infective 12.31 10.20 38 160387 2927 31533992
Diabetic ketoacidosis 12.30 10.20 44 160381 16861 31520058
Acute graft versus host disease 12.27 10.20 8 160417 6145 31530774
Developmental coordination disorder 12.26 10.20 9 160416 177 31536742
Erectile dysfunction 12.13 10.20 53 160372 19182 31517737
Nodule 12.12 10.20 59 160366 5631 31531288
Emphysema 12.10 10.20 82 160343 8836 31528083
Ear malformation 12.02 10.20 11 160414 298 31536621
Psychotic disorder 11.99 10.20 65 160360 22228 31514691
Suspected suicide 11.98 10.20 3 160422 4104 31532815
Neurotoxicity 11.97 10.20 42 160383 16184 31520735
Pancreatic calcification 11.88 10.20 9 160416 186 31536733
Palindromic rheumatism 11.84 10.20 9 160416 187 31536732
Cystitis haemorrhagic 11.80 10.20 6 160419 5283 31531636
Neutropenia 11.64 10.20 586 159839 139778 31397141
Gangrene neonatal 11.64 10.20 9 160416 192 31536727
Pleural fibrosis 11.60 10.20 23 160402 1340 31535579
Anaphylactic shock 11.55 10.20 35 160390 14110 31522809
Educational problem 11.50 10.20 14 160411 531 31536388
Fine motor skill dysfunction 11.46 10.20 26 160399 1664 31535255
Cleft palate 11.45 10.20 15 160410 613 31536306
Congenital hydronephrosis 11.33 10.20 16 160409 703 31536216
Injection site rash 11.24 10.20 43 160382 3693 31533226
Mean cell volume increased 11.19 10.20 36 160389 2836 31534083
Neonatal seizure 11.15 10.20 13 160412 471 31536448
Pulmonary artery stenosis congenital 11.10 10.20 13 160412 473 31536446
Folate deficiency 11.10 10.20 21 160404 1181 31535738
Sleep disorder due to a general medical condition 11.10 10.20 3 160422 3899 31533020
Hyperammonaemia 11.08 10.20 8 160417 5825 31531094
Withdrawal syndrome 11.06 10.20 27 160398 11690 31525229
Red blood cell count decreased 11.06 10.20 194 160231 26613 31510306
Pyelocaliectasis 11.00 10.20 20 160405 1091 31535828
Neonatal infection 10.97 10.20 12 160413 405 31536514
Meningeal disorder 10.97 10.20 11 160414 335 31536584
Incorrect route of product administration 10.94 10.20 27 160398 11646 31525273
Blood lactic acid increased 10.89 10.20 9 160416 6121 31530798
Injection site haemorrhage 10.85 10.20 81 160344 9004 31527915
Peritoneal dialysis complication 10.83 10.20 25 160400 1619 31535300
Hypermethioninaemia 10.81 10.20 3 160422 3 31536916
Haemolysis 10.79 10.20 68 160357 7148 31529771
Drug level increased 10.78 10.20 59 160366 20127 31516792
Excessive cerumen production 10.78 10.20 10 160415 276 31536643
Peripheral artery thrombosis 10.77 10.20 30 160395 2182 31534737
Pulmonary alveolar haemorrhage 10.75 10.20 11 160414 6755 31530164
Acute chest syndrome 10.73 10.20 11 160414 344 31536575
Tooth injury 10.71 10.20 20 160405 1114 31535805
Gross motor delay 10.63 10.20 10 160415 281 31536638
Nephrolithiasis 10.63 10.20 196 160229 27143 31509776
Injection site bruising 10.62 10.20 73 160352 7902 31529017
Acute generalised exanthematous pustulosis 10.57 10.20 9 160416 6031 31530888
Blood test abnormal 10.55 10.20 60 160365 6081 31530838
Cellulitis 10.55 10.20 318 160107 47700 31489219
Akinesia 10.54 10.20 28 160397 1980 31534939
Myalgia 10.52 10.20 304 160121 76954 31459965
Neutropenia neonatal 10.51 10.20 15 160410 666 31536253
Melaena 10.50 10.20 110 160315 32544 31504375
Prominent epicanthal folds 10.49 10.20 8 160417 167 31536752
Nail bed inflammation 10.49 10.20 8 160417 167 31536752
Respiratory tract infection viral 10.49 10.20 28 160397 1986 31534933
Ankylosing spondylitis 10.46 10.20 58 160367 5823 31531096
Anti-erythropoietin antibody positive 10.46 10.20 17 160408 847 31536072
Hepatitis fulminant 10.43 10.20 3 160422 3743 31533176
Lung neoplasm 10.34 10.20 47 160378 4359 31532560
Necrotising enterocolitis neonatal 10.27 10.20 9 160416 230 31536689
Iris hypopigmentation 10.27 10.20 5 160420 44 31536875
Psychomotor skills impaired 10.25 10.20 37 160388 3090 31533829
Aphasia 10.24 10.20 59 160366 19872 31517047
Hypoxia 10.23 10.20 186 160239 50127 31486792
Myopia 10.23 10.20 19 160406 1054 31535865
Heart rate irregular 10.21 10.20 114 160311 14175 31522744

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Rheumatoid arthritis 1648.25 9.97 4924 460979 286881 70175660
Completed suicide 1013.24 9.97 144 465759 226991 70235550
Arthropathy 914.23 9.97 2604 463299 147453 70315088
Pemphigus 908.25 9.97 1810 464093 81226 70381315
Joint swelling 886.24 9.97 3650 462253 249561 70212980
Systemic lupus erythematosus 884.70 9.97 2022 463881 99880 70362661
Hand deformity 874.71 9.97 1825 464078 84657 70377884
Synovitis 845.71 9.97 2302 463601 126926 70335615
Toxicity to various agents 830.09 9.97 773 465130 381399 70081142
Glossodynia 796.39 9.97 1757 464146 84730 70377811
Arthralgia 723.89 9.97 5713 460190 497677 69964864
Drug abuse 711.70 9.97 71 465832 147185 70315356
Maternal exposure during pregnancy 680.33 9.97 1979 463924 113366 70349175
Anti-cyclic citrullinated peptide antibody positive 672.45 9.97 1449 464454 68736 70393805
Wound 650.97 9.97 1764 464139 96968 70365573
Infusion related reaction 644.36 9.97 2788 463115 194746 70267795
Pericarditis 641.27 9.97 1594 464309 83111 70379430
Abdominal discomfort 548.90 9.97 2823 463080 211835 70250706
Pain 505.47 9.97 6324 459579 622492 69840049
Alopecia 502.28 9.97 2603 463300 195887 70266654
Swelling 494.84 9.97 2498 463405 186041 70276500
Therapeutic product effect decreased 491.20 9.97 2051 463852 140967 70321574
Discomfort 488.20 9.97 1664 464239 103772 70358769
Contraindicated product administered 450.99 9.97 1916 463987 132696 70329845
Drug interaction 415.88 9.97 1211 464692 380230 70082311
Duodenal ulcer perforation 413.52 9.97 987 464916 50125 70412416
Helicobacter infection 410.24 9.97 1037 464866 54619 70407922
Nasopharyngitis 409.73 9.97 2680 463223 219526 70243015
Drug intolerance 396.84 9.97 2690 463213 222997 70239544
Hepatic enzyme increased 396.43 9.97 2058 463845 154932 70307609
Death 396.41 9.97 1863 464040 508198 69954343
Musculoskeletal stiffness 389.84 9.97 1961 463942 145799 70316742
Rheumatoid factor positive 388.72 9.97 932 464971 47468 70415073
Intentional overdose 375.52 9.97 92 465811 98343 70364198
Exposure during pregnancy 341.10 9.97 1308 464595 86409 70376132
Acute kidney injury 309.15 9.97 1840 464063 472784 69989757
Febrile neutropenia 279.50 9.97 576 465327 203742 70258799
Impaired healing 269.66 9.97 1085 464818 73289 70389252
Psoriatic arthropathy 262.65 9.97 979 464924 63792 70398749
Treatment failure 246.52 9.97 1707 464196 142435 70320106
C-reactive protein abnormal 241.86 9.97 677 465226 37902 70424639
Hypersensitivity 241.66 9.97 2439 463464 227373 70235168
Cardiac arrest 239.15 9.97 427 465476 159407 70303134
Peripheral swelling 238.92 9.97 2490 463413 234073 70228468
Sinusitis 238.51 9.97 1914 463989 167281 70295260
Muscle injury 237.89 9.97 672 465231 37822 70424719
Lower respiratory tract infection 236.83 9.97 1399 464504 110514 70352027
Overdose 230.03 9.97 481 465422 169264 70293277
Product use issue 224.19 9.97 1980 463923 177957 70284584
Folliculitis 220.32 9.97 698 465205 41872 70420669
Irritable bowel syndrome 219.16 9.97 784 465119 50066 70412475
Red blood cell sedimentation rate abnormal 205.14 9.97 416 465487 18887 70443654
Depressed level of consciousness 204.94 9.97 164 465739 87267 70375274
Sleep disorder due to general medical condition, insomnia type 203.67 9.97 606 465297 35126 70427415
Blister 197.66 9.97 1233 464670 99293 70363248
Suicide attempt 196.80 9.97 141 465762 79369 70383172
Arthritis 188.43 9.97 1195 464708 96785 70365756
Bradycardia 185.41 9.97 334 465569 124281 70338260
Blood pressure fluctuation 176.26 9.97 812 465091 58200 70404341
Knee arthroplasty 175.29 9.97 560 465343 33741 70428800
Sickle cell anaemia with crisis 173.08 9.97 205 465698 5773 70456768
Hip arthroplasty 172.76 9.97 489 465414 27551 70434990
Rhabdomyolysis 170.83 9.97 227 465676 95533 70367008
Weight increased 170.20 9.97 2381 463522 239950 70222591
Respiratory arrest 169.23 9.97 71 465832 53862 70408679
Osteoarthritis 168.64 9.97 945 464958 73202 70389339
Cardiac failure 164.76 9.97 444 465459 143097 70319444
Pregnancy 162.72 9.97 431 465472 23350 70439191
Sedation 155.75 9.97 56 465847 46675 70415866
Renal failure 149.69 9.97 685 465218 188385 70274156
Drug reaction with eosinophilia and systemic symptoms 144.71 9.97 102 465801 57911 70404630
Sopor 143.60 9.97 18 465885 31249 70431292
Infection 139.18 9.97 2049 463854 208736 70253805
Malignant neoplasm progression 138.62 9.97 378 465525 121361 70341180
Disease progression 137.93 9.97 545 465358 156127 70306414
Lactic acidosis 137.88 9.97 134 465769 64890 70397651
Abortion spontaneous 132.30 9.97 429 465474 26050 70436491
Neutropenia 131.04 9.97 1070 464833 256086 70206455
Rheumatic fever 130.02 9.97 329 465574 17331 70445210
Drug ineffective 128.69 9.97 7466 458437 932286 69530255
Hypotension 128.48 9.97 1876 464027 402505 70060036
Ill-defined disorder 126.68 9.97 701 465202 54040 70408501
Serotonin syndrome 124.98 9.97 60 465843 42054 70420487
Drug dependence 122.22 9.97 46 465857 37275 70425266
Blood pressure systolic increased 119.91 9.97 714 465189 56545 70405996
Red blood cell sedimentation rate increased 119.31 9.97 537 465366 38105 70424436
Hepatic function abnormal 118.42 9.97 164 465739 67832 70394709
Hypoglycaemia 114.30 9.97 284 465619 94080 70368461
Contusion 112.25 9.97 1311 464592 126725 70335816
Blood pressure diastolic abnormal 111.20 9.97 286 465617 15218 70447323
Agitation 110.80 9.97 284 465619 93091 70369450
Condition aggravated 109.71 9.97 3627 462276 424008 70038533
Coma 109.24 9.97 279 465624 91565 70370976
Swollen joint count increased 106.94 9.97 261 465642 13439 70449102
Fatigue 104.93 9.97 6508 459395 817811 69644730
Cytomegalovirus infection 104.42 9.97 66 465837 39692 70422849
Cardio-respiratory arrest 103.43 9.97 328 465575 100349 70362192
Fibromyalgia 102.83 9.97 601 465302 47273 70415268
Respiratory failure 101.32 9.97 670 465233 168065 70294476
Drug resistance 100.84 9.97 63 465840 38127 70424414
Enthesopathy 99.01 9.97 220 465683 10649 70451892
Renal impairment 98.76 9.97 548 465355 143389 70319152
Joint effusion 98.37 9.97 273 465630 15204 70447337
Injection site erythema 98.34 9.97 817 465086 72107 70390434
Somnolence 98.34 9.97 923 464980 214683 70247858
Blood pressure systolic abnormal 96.61 9.97 242 465661 12667 70449874
Foot deformity 96.38 9.97 327 465576 20328 70442213
Rash 96.19 9.97 4185 461718 506377 69956164
Osteoporosis 94.29 9.97 597 465306 48310 70414231
C-reactive protein increased 92.19 9.97 1121 464782 109396 70353145
Grip strength decreased 91.26 9.97 268 465635 15417 70447124
Product use in unapproved indication 90.89 9.97 897 465006 206581 70255960
Intentional self-injury 89.56 9.97 48 465855 31602 70430939
Hyperglycaemia 88.60 9.97 182 465721 64490 70398051
Blood pressure diastolic decreased 88.57 9.97 370 465533 25410 70437131
Hepatic failure 86.98 9.97 153 465750 57472 70405069
Gastrointestinal disorder 86.91 9.97 1067 464836 104360 70358181
Rheumatoid nodule 86.29 9.97 256 465647 14811 70447730
Syncope 85.03 9.97 688 465215 165021 70297520
Pain in extremity 84.65 9.97 2785 463118 325297 70137244
Inflammation 83.53 9.97 837 465066 77828 70384713
Live birth 82.64 9.97 238 465665 13541 70449000
Constipation 81.84 9.97 1166 464737 251272 70211269
Injection site pruritus 81.48 9.97 488 465415 38722 70423819
Cardiac failure congestive 81.23 9.97 538 465365 134919 70327622
Stomatitis 81.15 9.97 1240 464663 127271 70335270
Tachycardia 81.01 9.97 659 465244 157887 70304654
Poisoning 80.86 9.97 24 465879 22598 70439943
Intentional product misuse 80.58 9.97 261 465642 79334 70383207
Shock 80.38 9.97 88 465815 40337 70422204
Angioedema 80.25 9.97 201 465702 66409 70396132
Disseminated intravascular coagulation 80.00 9.97 62 465841 33536 70429005
Disability assessment scale score increased 79.67 9.97 98 465805 2873 70459668
Musculoskeletal pain 79.64 9.97 926 464977 89401 70373140
Tenosynovitis 79.60 9.97 237 465666 13739 70448802
Device expulsion 78.79 9.97 24 465879 22222 70440319
Intentional product use issue 78.47 9.97 1166 464737 118976 70343565
Altered state of consciousness 76.45 9.97 90 465813 39932 70422609
Bone erosion 75.95 9.97 246 465657 14927 70447614
Drug withdrawal syndrome 75.85 9.97 62 465841 32653 70429888
Heart rate decreased 75.36 9.97 679 465224 61336 70401205
Hypoxia 75.13 9.97 336 465567 93008 70369533
Joint stiffness 73.23 9.97 438 465465 34738 70427803
Neoplasm progression 72.98 9.97 115 465788 45113 70417428
Respiratory depression 71.23 9.97 37 465866 24794 70437747
Pulmonary arterial hypertension 70.47 9.97 67 465836 32788 70429753
Tuberculosis 69.21 9.97 235 465668 14613 70447928
Blood creatine phosphokinase increased 69.13 9.97 191 465712 61072 70401469
Injection site reaction 69.08 9.97 562 465341 49290 70413251
Blood cholesterol increased 68.88 9.97 688 465215 63916 70398625
Sedation complication 68.75 9.97 5 465898 13405 70449136
Hyperhidrosis 68.57 9.97 544 465359 131042 70331499
Delirium 68.56 9.97 255 465648 74359 70388182
Asthma 68.34 9.97 488 465415 120305 70342236
Caesarean section 68.18 9.97 199 465704 11408 70451133
Cerebral haemorrhage 66.88 9.97 160 465743 53704 70408837
Metabolic acidosis 66.43 9.97 257 465646 74089 70388452
Myocardial infarction 65.52 9.97 766 465137 170879 70291662
Cholestasis 65.34 9.97 135 465768 47737 70414804
Plasma cell myeloma 64.79 9.97 254 465649 72947 70389594
Tremor 64.34 9.97 682 465221 154942 70307599
Joint laxity 64.09 9.97 78 465825 2261 70460280
Cognitive disorder 63.01 9.97 198 465705 60758 70401783
Injection site pain 62.78 9.97 1104 464799 116515 70346026
Loss of personal independence in daily activities 62.22 9.97 841 465062 84069 70378472
Hyperkalaemia 62.08 9.97 427 465476 106164 70356377
Thrombocytopenia 61.41 9.97 1153 464750 237957 70224584
Injection site swelling 61.14 9.97 489 465414 42668 70419873
Myalgia 61.12 9.97 757 465146 167135 70295406
Polyarthritis 60.88 9.97 182 465721 10574 70451967
Hepatocellular injury 60.38 9.97 133 465770 45958 70416583
Psoriasis 60.30 9.97 945 464958 97488 70365053
Hypothermia 60.10 9.97 30 465873 20564 70441977
Localised infection 59.78 9.97 398 465505 32760 70429781
Multiple organ dysfunction syndrome 59.17 9.97 443 465460 108072 70354469
Basal cell carcinoma 58.67 9.97 401 465502 33297 70429244
Joint range of motion decreased 58.02 9.97 330 465573 25696 70436845
Blood pressure increased 57.84 9.97 1635 464268 186882 70275659
Gestational diabetes 57.54 9.97 124 465779 5877 70456664
Ventricular tachycardia 57.46 9.97 94 465809 36329 70426212
Neuroleptic malignant syndrome 57.00 9.97 52 465851 25955 70436586
Dehydration 56.98 9.97 1094 464809 225048 70237493
Juvenile idiopathic arthritis 56.94 9.97 121 465782 5679 70456862
Anxiety 56.71 9.97 1062 464841 219268 70243273
Mydriasis 56.18 9.97 18 465885 16135 70446406
Joint destruction 55.99 9.97 106 465797 4572 70457969
Body temperature decreased 55.26 9.97 350 465553 28322 70434219
Pulmonary fibrosis 54.89 9.97 400 465503 33910 70428631
Tongue disorder 54.48 9.97 201 465702 13026 70449515
Nodule 53.96 9.97 267 465636 19702 70442839
Post transplant lymphoproliferative disorder 53.86 9.97 4 465899 10541 70452000
Hallucination 53.57 9.97 288 465615 75972 70386569
Tendonitis 52.99 9.97 286 465617 21836 70440705
Femur fracture 52.61 9.97 412 465491 35720 70426821
Atrial fibrillation 52.07 9.97 874 465029 183474 70279067
Acute hepatic failure 52.03 9.97 63 465840 27609 70434932
Orthostatic hypotension 51.45 9.97 171 465732 51572 70410969
Mental status changes 50.85 9.97 227 465676 62874 70399667
Blood pressure diastolic increased 50.79 9.97 188 465715 12203 70450338
Hyponatraemia 50.59 9.97 743 465160 159344 70303197
Laryngitis 50.28 9.97 200 465703 13431 70449110
Maternal exposure before pregnancy 50.12 9.97 90 465813 3726 70458815
Red blood cell sedimentation rate 50.02 9.97 104 465799 4806 70457735
Disability 49.88 9.97 213 465690 14770 70447771
Encephalopathy 49.58 9.97 222 465681 61439 70401102
Venoocclusive liver disease 49.39 9.97 6 465897 10672 70451869
Dyspnoea 49.32 9.97 4372 461531 765688 69696853
Melaena 48.95 9.97 197 465706 56158 70406383
Oropharyngeal pain 48.91 9.97 897 465006 95413 70367128
Disorientation 48.73 9.97 205 465698 57718 70404823
Appendicolith 48.43 9.97 112 465791 5568 70456973
Speech disorder 48.36 9.97 170 465733 50410 70412131
Latent tuberculosis 48.07 9.97 79 465824 3042 70459499
Injection site bruising 48.05 9.97 420 465483 37612 70424929
Unresponsive to stimuli 48.02 9.97 177 465726 51754 70410787
Leukopenia 47.76 9.97 458 465445 106102 70356439
Suicidal ideation 47.69 9.97 265 465638 69331 70393210
Anaphylactic shock 47.47 9.97 88 465815 32402 70430139
Alanine aminotransferase abnormal 47.17 9.97 138 465765 7921 70454620
Restlessness 47.04 9.97 132 465771 41996 70420545
Disturbance in attention 46.72 9.97 136 465767 42758 70419783
Posterior reversible encephalopathy syndrome 46.47 9.97 55 465848 24347 70438194
Abnormal behaviour 46.42 9.97 99 465804 34610 70427931
Palmar-plantar erythrodysaesthesia syndrome 45.92 9.97 80 465823 30167 70432374
Pulmonary embolism 45.65 9.97 734 465169 155133 70307408
Electrocardiogram QT prolonged 45.50 9.97 341 465562 83176 70379365
Gastrointestinal haemorrhage 45.44 9.97 632 465271 136776 70325765
Neutrophil count decreased 45.13 9.97 342 465561 83214 70379327
Aspergillus infection 45.11 9.97 31 465872 17837 70444704
Premature delivery 44.81 9.97 266 465637 21038 70441503
Diabetic ketoacidosis 44.60 9.97 87 465816 31425 70431116
Substance abuse 44.36 9.97 6 465897 9831 70452710
Ejection fraction decreased 44.35 9.97 84 465819 30678 70431863
Drug ineffective for unapproved indication 44.34 9.97 119 465784 38419 70424122
Pathogen resistance 44.10 9.97 16 465887 13263 70449278
Tenderness 44.08 9.97 264 465639 20946 70441595
Diarrhoea 43.84 9.97 4492 461411 778849 69683692
Mobility decreased 43.48 9.97 933 464970 102066 70360475
Injection site rash 43.34 9.97 218 465685 16192 70446349
Infective pulmonary exacerbation of cystic fibrosis 43.27 9.97 13 465890 12145 70450396
Synovial cyst 43.09 9.97 141 465762 8601 70453940
Second primary malignancy 42.88 9.97 16 465887 13035 70449506
Asphyxia 42.82 9.97 8 465895 10334 70452207
Seizure 42.68 9.97 868 465035 177094 70285447
Asthenia 42.42 9.97 2517 463386 455149 70007392
Torsade de pointes 42.41 9.97 34 465869 18082 70444459
Neck deformity 42.32 9.97 55 465848 1706 70460835
Balance disorder 42.27 9.97 383 465520 89745 70372796
Depression 42.10 9.97 990 464913 197984 70264557
Neck mass 41.87 9.97 88 465815 4098 70458443
Product quality issue 41.86 9.97 86 465817 30475 70432066
Drug level increased 41.66 9.97 113 465790 36356 70426185
Premature labour 41.22 9.97 131 465772 7869 70454672
Skin ulcer 40.84 9.97 490 465413 47655 70414886
Pre-eclampsia 40.83 9.97 114 465789 6371 70456170
Accidental overdose 40.74 9.97 108 465795 35013 70427528
Multiple fractures 40.71 9.97 117 465786 6648 70455893
Myoclonus 40.66 9.97 69 465834 26286 70436255
Rash maculo-papular 40.62 9.97 182 465721 50363 70412178
Adverse event 40.48 9.97 500 465403 48961 70413580
Extrapyramidal disorder 40.34 9.97 46 465857 20704 70441837
Respiratory distress 40.28 9.97 203 465700 54447 70408094
Pulmonary oedema 40.19 9.97 346 465557 81932 70380609
Multiple sclerosis relapse 40.18 9.97 146 465757 42871 70419670
Cerebral infarction 40.16 9.97 146 465757 42863 70419678
Ear infection 40.09 9.97 321 465582 28015 70434526
Arrhythmia 40.00 9.97 211 465692 55932 70406609
Fluid retention 39.89 9.97 248 465655 63137 70399404
Aggression 39.81 9.97 173 465730 48273 70414268
Dizziness 39.29 9.97 2574 463329 461567 70000974
Cytokine release syndrome 39.28 9.97 71 465832 26396 70436145
Drug use disorder 39.17 9.97 4 465899 8147 70454394
Premature rupture of membranes 39.05 9.97 82 465821 3816 70458725
Blood glucose increased 38.73 9.97 461 465442 102521 70360020
Withdrawal syndrome 38.60 9.97 65 465838 24839 70437702
Irritability 38.22 9.97 126 465777 38099 70424442
Poor venous access 38.22 9.97 197 465706 14774 70447767
Coronary artery disease 38.18 9.97 248 465655 62488 70400053
Fracture 38.15 9.97 243 465660 19701 70442840
No adverse event 37.97 9.97 98 465805 32055 70430486
Immune reconstitution inflammatory syndrome 37.79 9.97 19 465884 12971 70449570
Urticaria 37.69 9.97 800 465103 162249 70300292
Thrombotic microangiopathy 37.57 9.97 37 465866 17811 70444730
Agranulocytosis 37.49 9.97 137 465766 40161 70422380
Akathisia 37.26 9.97 17 465886 12276 70450265
Limb deformity 37.20 9.97 75 465828 3390 70459151
Creatinine renal clearance decreased 36.97 9.97 35 465868 17165 70445376
Joint dislocation 36.95 9.97 191 465712 14340 70448201
Exostosis 36.79 9.97 189 465714 14156 70448385
Mouth ulceration 36.70 9.97 366 465537 33983 70428558
Graft versus host disease 36.69 9.97 27 465876 14996 70447545
Loss of consciousness 36.59 9.97 762 465141 154954 70307587
Coagulopathy 36.52 9.97 105 465798 33144 70429397
Therapeutic response decreased 36.48 9.97 563 465340 57890 70404651
Acute graft versus host disease 36.33 9.97 9 465894 9553 70452988
Colorectal cancer 36.28 9.97 6 465897 8464 70454077
Lupus-like syndrome 36.27 9.97 161 465742 11354 70451187
Eosinophilia 36.25 9.97 139 465764 40180 70422361
Bronchopulmonary aspergillosis 36.21 9.97 51 465852 20951 70441590
Vomiting 36.21 9.97 3379 462524 589732 69872809
Cerebrovascular accident 36.13 9.97 694 465209 142776 70319765
Joint injury 35.90 9.97 301 465602 26631 70435910
Mucormycosis 35.87 9.97 5 465898 8009 70454532
Vision blurred 35.79 9.97 425 465478 94559 70367982
Transplant rejection 35.64 9.97 40 465863 18131 70444410
Subdural haematoma 35.60 9.97 88 465815 29210 70433331
Hypokalaemia 35.41 9.97 627 465276 130561 70331980
Type 2 diabetes mellitus 35.39 9.97 444 465459 43636 70418905
Herpes zoster 35.30 9.97 770 465133 84465 70378076
Arthritis infective 35.16 9.97 118 465785 7294 70455247
Miosis 34.89 9.97 25 465878 14076 70448465
Product administration error 34.85 9.97 90 465813 29433 70433108
Smear cervix abnormal 34.71 9.97 59 465844 2337 70460204
Pulmonary tuberculosis 34.68 9.97 122 465781 7723 70454818
Maternal exposure timing unspecified 34.64 9.97 84 465819 4307 70458234
Blood parathyroid hormone decreased 34.58 9.97 134 465769 8890 70453651
Osteonecrosis of jaw 34.56 9.97 145 465758 40857 70421684
Blood creatinine increased 34.42 9.97 697 465206 142304 70320237
Emotional distress 34.22 9.97 127 465776 37061 70425480
Fear of injection 34.14 9.97 109 465794 6563 70455978
Stevens-Johnson syndrome 34.11 9.97 121 465782 35786 70426755
Ischaemic stroke 34.09 9.97 97 465806 30723 70431818
Tachypnoea 34.04 9.97 87 465816 28551 70433990
Psychomotor hyperactivity 33.65 9.97 31 465872 15402 70447139
Neurotoxicity 33.63 9.97 93 465810 29733 70432808
Wrong technique in product usage process 33.50 9.97 289 465614 68409 70394132
Anaphylactic reaction 33.27 9.97 323 465580 74651 70387890
Acute respiratory failure 33.24 9.97 211 465692 53454 70409087
Nausea 33.20 9.97 5002 460901 847086 69615455
Chronic kidney disease 32.92 9.97 250 465653 60807 70401734
Haematotoxicity 32.85 9.97 25 465878 13649 70448892
Proteinuria 32.82 9.97 92 465811 29282 70433259
Anaemia 32.66 9.97 2246 463657 401177 70061364
Acute myeloid leukaemia 32.33 9.97 100 465803 30840 70431701
Gastroenteritis viral 31.98 9.97 246 465657 21209 70441332
Tumour lysis syndrome 31.97 9.97 57 465846 21303 70441238
Blood alkaline phosphatase increased 31.85 9.97 239 465664 58282 70404259
Forced expiratory volume decreased 31.73 9.97 5 465898 7309 70455232
Acute respiratory distress syndrome 31.70 9.97 151 465752 41103 70421438
Fear 31.63 9.97 55 465848 20756 70441785
Bursitis 31.36 9.97 290 465613 26383 70436158
Bradyphrenia 31.35 9.97 13 465890 9933 70452608
Immunodeficiency 31.21 9.97 210 465693 17345 70445196
Wheelchair user 31.21 9.97 90 465813 5124 70457417
Haemorrhage 31.20 9.97 376 465527 83439 70379102
Angina pectoris 31.13 9.97 188 465715 48195 70414346
Granuloma skin 31.02 9.97 116 465787 7566 70454975
Unintentional medical device removal 30.62 9.97 5 465898 7119 70455422
Tenosynovitis stenosans 30.61 9.97 55 465848 2278 70460263
Deep vein thrombosis 30.51 9.97 529 465374 110513 70352028
Haemorrhage intracranial 30.44 9.97 74 465829 24703 70437838
Bone disorder 30.36 9.97 208 465695 17282 70445259
Psychotic disorder 30.15 9.97 136 465767 37565 70424976
Rotator cuff repair 29.88 9.97 45 465858 1606 70460935
Pleural effusion 29.52 9.97 656 465247 132208 70330333
BK virus infection 29.43 9.97 8 465895 7981 70454560
Foot fracture 29.37 9.97 225 465678 19375 70443166
Dysarthria 29.13 9.97 265 465638 62048 70400493
Decreased appetite 28.94 9.97 1672 464231 303108 70159433
Spinal stenosis 28.94 9.97 180 465723 14473 70448068
Erythema multiforme 28.78 9.97 40 465863 16524 70446017
Joint noise 28.54 9.97 67 465836 3364 70459177
Oral herpes 28.45 9.97 263 465640 23923 70438618
Aphasia 28.38 9.97 167 465736 43082 70419459
Panniculitis 28.32 9.97 142 465761 10534 70452007
Chest discomfort 28.24 9.97 612 465291 123769 70338772
Hyperthermia 28.23 9.97 41 465862 16630 70445911
Acute generalised exanthematous pustulosis 27.96 9.97 36 465867 15361 70447180
Gamma-glutamyltransferase increased 27.58 9.97 207 465696 50478 70412063
Peripheral venous disease 27.54 9.97 141 465762 10546 70451995
Pulmonary alveolar haemorrhage 27.52 9.97 17 465886 10352 70452189
Inappropriate antidiuretic hormone secretion 27.44 9.97 71 465832 23205 70439336
Face oedema 27.41 9.97 82 465821 25557 70436984
Skin papilloma 27.38 9.97 88 465815 5318 70457223
Respiratory disorder 27.33 9.97 148 465755 38975 70423566
Leukocytosis 27.20 9.97 151 465752 39517 70423024
Hallucination, visual 27.12 9.97 100 465803 29237 70433304
Retinitis 27.05 9.97 74 465829 4086 70458455
Synovial fluid analysis 27.04 9.97 46 465857 1823 70460718
Hypermethioninaemia 26.90 9.97 10 465893 29 70462512
Ulcer 26.83 9.97 273 465630 25481 70437060
Acute graft versus host disease in skin 26.57 9.97 7 465896 7130 70455411
Mania 26.46 9.97 45 465858 17129 70445412
Influenza 26.43 9.97 954 464949 112746 70349795
Brain oedema 26.42 9.97 73 465830 23345 70439196
Acute myocardial infarction 26.37 9.97 329 465574 72558 70389983
Bronchitis 26.35 9.97 980 464923 116263 70346278
Febrile bone marrow aplasia 26.25 9.97 24 465879 11967 70450574
Acute chest syndrome 26.23 9.97 32 465871 930 70461611
Loose body in joint 26.21 9.97 37 465866 1244 70461297
Haemoptysis 26.19 9.97 214 465689 51238 70411303
Clostridium difficile colitis 26.04 9.97 100 465803 28896 70433645
Cardiac failure acute 25.87 9.97 47 465856 17440 70445101
Lip dry 25.85 9.97 130 465773 9655 70452886
Dyspnoea exertional 25.82 9.97 361 465542 78069 70384472
Schizophrenia 25.77 9.97 44 465859 16724 70445817
General physical health deterioration 25.77 9.97 1841 464062 234190 70228351
Flushing 25.73 9.97 382 465521 81790 70380751
Cyanosis 25.69 9.97 73 465830 23133 70439408
Pancreatitis acute 25.42 9.97 183 465720 45041 70417500
International normalised ratio increased 25.37 9.97 375 465528 80351 70382190
Haemophagocytic lymphohistiocytosis 25.35 9.97 57 465846 19555 70442986
Klebsiella infection 25.35 9.97 34 465869 14258 70448283
Pulmonary hypertension 25.35 9.97 190 465713 46346 70416195
Haematoma 25.28 9.97 200 465703 48218 70414323
Pemphigoid 25.24 9.97 33 465870 13989 70448552
Potentiating drug interaction 25.20 9.97 11 465892 8153 70454388
Dysgeusia 25.15 9.97 206 465697 49296 70413245
Stress cardiomyopathy 25.04 9.97 17 465886 9845 70452696
Interstitial lung disease 24.96 9.97 511 465392 104174 70358367
Injection site warmth 24.95 9.97 166 465737 13659 70448882
Hepatitis B reactivation 24.79 9.97 3 465900 5352 70457189
Shock haemorrhagic 24.75 9.97 51 465852 18055 70444486
Chronic graft versus host disease 24.53 9.97 7 465896 6763 70455778
Facet joint syndrome 24.43 9.97 92 465811 6021 70456520
Pain in jaw 24.31 9.97 172 465731 42497 70420044
Bronchospasm 24.29 9.97 73 465830 22719 70439822
Foetal death 24.20 9.97 93 465810 6146 70456395
Blood pressure decreased 24.18 9.97 439 465464 91076 70371465
Blood bilirubin increased 24.14 9.97 264 465639 59637 70402904
Device use error 24.12 9.97 7 465896 6689 70455852
Fracture delayed union 23.84 9.97 46 465857 2013 70460528
Cytomegalovirus viraemia 23.71 9.97 25 465878 11660 70450881
Dysphagia 23.68 9.97 562 465341 112272 70350269
Nightmare 23.58 9.97 71 465832 22085 70440456
Skin cancer 23.51 9.97 161 465742 13375 70449166
Cytopenia 23.51 9.97 49 465854 17274 70445267
Nocardiosis 23.44 9.97 3 465900 5126 70457415
Device difficult to use 23.41 9.97 22 465881 10827 70451714
Dystonia 23.31 9.97 60 465843 19646 70442895
Hyperammonaemia 23.25 9.97 20 465883 10273 70452268
Adenovirus infection 23.15 9.97 11 465892 7757 70454784
Scleritis 23.13 9.97 64 465839 3558 70458983
Progressive multifocal leukoencephalopathy 23.12 9.97 58 465845 19156 70443385
Hallucination, auditory 23.10 9.97 54 465849 18274 70444267
Anhedonia 23.06 9.97 36 465867 14177 70448364
Polyhydramnios 23.03 9.97 38 465865 1468 70461073
Vertigo 22.94 9.97 282 465621 62361 70400180
Metastases to bone 22.90 9.97 73 465830 22303 70440238
Pancytopenia 22.90 9.97 1213 464690 149894 70312647
Epstein-Barr virus infection 22.80 9.97 32 465871 13166 70449375
Breast cancer stage I 22.69 9.97 6 465897 6096 70456445
Muscle spasticity 22.49 9.97 61 465842 19628 70442913
Pulmonary congestion 22.43 9.97 87 465816 25067 70437474
Rhinorrhoea 22.42 9.97 583 465320 65788 70396753
Dislocation of vertebra 22.35 9.97 77 465826 4823 70457718
Platelet count decreased 22.30 9.97 950 464953 177272 70285269
Disease recurrence 22.20 9.97 150 465753 37453 70425088
Metastases to liver 22.13 9.97 91 465812 25787 70436754
Acidosis 22.08 9.97 55 465848 18208 70444333
Pancreatitis 21.88 9.97 285 465618 62383 70400158
White blood cell count decreased 21.69 9.97 905 464998 169236 70293305
Malignant melanoma 21.63 9.97 161 465742 13739 70448802
Anuria 21.63 9.97 62 465841 19591 70442950
Respiration abnormal 21.59 9.97 9 465894 6855 70455686
Cystitis haemorrhagic 21.57 9.97 15 465888 8578 70453963
Tubulointerstitial nephritis 21.55 9.97 128 465775 32948 70429593
Surgery 21.54 9.97 296 465607 29693 70432848
Pneumatosis intestinalis 21.49 9.97 6 465897 5881 70456660
Delusion 21.43 9.97 60 465843 19105 70443436
Exposure to toxic agent 21.37 9.97 7 465896 6187 70456354
Sepsis 21.36 9.97 1352 464551 243193 70219348
Cyst 21.34 9.97 150 465753 12569 70449972
Haemoglobin decreased 21.33 9.97 1594 464309 203565 70258976
Labelled drug-drug interaction medication error 21.16 9.97 84 465819 24043 70438498
Electrocardiogram QRS complex prolonged 21.02 9.97 20 465883 9786 70452755
Post procedural infection 20.96 9.97 128 465775 10225 70452316
Hyperthyroidism 20.94 9.97 65 465838 20026 70442515
Acute coronary syndrome 20.90 9.97 65 465838 20014 70442527
Toxic epidermal necrolysis 20.84 9.97 163 465740 39394 70423147
Drug tolerance decreased 20.82 9.97 123 465780 9710 70452831
Anti-cyclic citrullinated peptide antibody 20.81 9.97 59 465844 3326 70459215
Diabetes insipidus 20.71 9.97 3 465900 4668 70457873
Dermatitis acneiform 20.68 9.97 17 465886 8928 70453613
Sciatica 20.60 9.97 250 465653 24377 70438164
Red blood cell count decreased 20.58 9.97 468 465435 51693 70410848
Cardiomyopathy 20.57 9.97 96 465807 26277 70436264
Urinary retention 20.56 9.97 233 465670 52287 70410254
Jaundice 20.53 9.97 220 465683 49888 70412653
Malignant mediastinal neoplasm 20.52 9.97 27 465876 848 70461693
Postoperative wound infection 20.38 9.97 136 465767 11202 70451339
Muscle spasms 20.36 9.97 816 465087 153230 70309311
Appendicitis 20.21 9.97 183 465720 16550 70445991
Oliguria 20.07 9.97 43 465860 15008 70447533
Synovial disorder 19.87 9.97 30 465873 1073 70461468
Adjustment disorder with depressed mood 19.82 9.97 67 465836 4156 70458385
Polyneuropathy 19.79 9.97 73 465830 21342 70441199
Glycosylated haemoglobin increased 19.78 9.97 54 465849 17337 70445204
Cardiac failure chronic 19.71 9.97 23 465880 10246 70452295
Bone pain 19.68 9.97 226 465677 50596 70411945
Antinuclear antibody positive 19.64 9.97 93 465810 6740 70455801
Chest pain 19.62 9.97 1403 464500 249857 70212684
Compartment syndrome 19.61 9.97 3 465900 4483 70458058
Hyperuricaemia 19.54 9.97 26 465877 10940 70451601
Hepatocellular carcinoma 19.45 9.97 23 465880 10185 70452356
Blood lactic acid increased 19.39 9.97 27 465876 11146 70451395
Gastric haemorrhage 19.36 9.97 40 465863 14145 70448396
Oxygen saturation decreased 19.35 9.97 943 464960 115486 70347055
Hemiparesis 19.35 9.97 124 465779 31345 70431196
Stillbirth 19.32 9.97 62 465841 3743 70458798
Tardive dyskinesia 19.31 9.97 22 465881 9907 70452634
Pharyngitis streptococcal 19.25 9.97 117 465786 9331 70453210
Weight decreased 19.20 9.97 2325 463578 308163 70154378
Palpitations 19.20 9.97 567 465336 110186 70352355
Incorrect route of product administration 19.18 9.97 99 465804 26393 70436148
Pulseless electrical activity 19.12 9.97 36 465867 13179 70449362
Hemiplegia 19.11 9.97 39 465864 13856 70448685
Sexual dysfunction 19.10 9.97 10 465893 6671 70455870
Skin necrosis 19.09 9.97 177 465726 16114 70446427
Dactylitis 19.00 9.97 44 465859 2189 70460352
Polyuria 18.98 9.97 37 465866 13369 70449172
Hypervolaemia 18.93 9.97 168 465735 39538 70423003
Septic shock 18.89 9.97 577 465326 111681 70350860
Breast feeding 18.70 9.97 23 465880 674 70461867
Foetal distress syndrome 18.68 9.97 19 465884 449 70462092
Presyncope 18.47 9.97 157 465746 37281 70425260
Ileus 18.45 9.97 89 465814 24148 70438393
Endodontic procedure 18.40 9.97 47 465856 2490 70460051
Wound infection 18.30 9.97 186 465717 17356 70445185
Hyperbilirubinaemia 18.29 9.97 81 465822 22487 70440054
Ingrown hair 18.29 9.97 22 465881 630 70461911
Dyskinesia 18.20 9.97 177 465726 40897 70421644
Rheumatoid lung 18.15 9.97 57 465846 3402 70459139
Human antichimeric antibody positive 18.13 9.97 34 465869 1456 70461085
Induced labour 18.06 9.97 25 465878 825 70461716
Muscle twitching 18.05 9.97 68 465835 19759 70442782
Pseudomonas infection 18.05 9.97 64 465839 18930 70443611
Pleuritic pain 18.02 9.97 110 465793 8787 70453754
Pyrexia 17.96 9.97 3616 462287 603336 69859205
Hypomagnesaemia 17.92 9.97 176 465727 40588 70421953
Upper respiratory tract infection 17.90 9.97 663 465240 78611 70383930
Sinus bradycardia 17.84 9.97 87 465816 23536 70439005
Aspartate aminotransferase increased 17.79 9.97 668 465235 126310 70336231
Bacteraemia 17.76 9.97 116 465787 29193 70433348
Musculoskeletal disorder 17.71 9.97 205 465698 19766 70442775
Respiratory acidosis 17.69 9.97 25 465878 10256 70452285
Persecutory delusion 17.66 9.97 4 465899 4513 70458028
Muscle rigidity 17.61 9.97 63 465840 18587 70443954
Normal newborn 17.57 9.97 85 465818 6215 70456326
Pulmonary haemorrhage 17.46 9.97 40 465863 13633 70448908
Right ventricular failure 17.42 9.97 81 465822 22193 70440348
Temperature regulation disorder 17.24 9.97 4 465899 4440 70458101
Hypertransaminasaemia 17.20 9.97 20 465883 8923 70453618
Toxic skin eruption 17.18 9.97 71 465832 20091 70442450
Hyperprolactinaemia 17.07 9.97 4 465899 4409 70458132
Erectile dysfunction 17.06 9.97 40 465863 13522 70449019
Accidental exposure to product 17.01 9.97 111 465792 27940 70434601
Haemorrhage in pregnancy 16.98 9.97 31 465872 1300 70461241
Catatonia 16.96 9.97 17 465886 8116 70454425
Enterocolitis 16.87 9.97 38 465865 13028 70449513
Dry eye 16.85 9.97 302 465601 31980 70430561
Graft versus host disease in skin 16.74 9.97 8 465895 5622 70456919
Lip swelling 16.72 9.97 143 465760 33911 70428630
Myocardial ischaemia 16.65 9.97 92 465811 24108 70438433
Abortion missed 16.64 9.97 29 465874 1172 70461369
Haematemesis 16.64 9.97 223 465680 48574 70413967
Blood calcium decreased 16.57 9.97 116 465787 28730 70433811
Coronary arterial stent insertion 16.55 9.97 9 465894 5878 70456663
Cushingoid 16.54 9.97 103 465800 8285 70454256
Paralysis 16.51 9.97 34 465869 12038 70450503
Troponin increased 16.45 9.97 55 465848 16559 70445982
Drug abuser 16.43 9.97 9 465894 5855 70456686
Sinus tachycardia 16.38 9.97 143 465760 33770 70428771
Foetal exposure during pregnancy 16.35 9.97 77 465826 5568 70456973
Affective disorder 16.33 9.97 15 465888 7464 70455077
Drug screen positive 16.31 9.97 9 465894 5831 70456710
Feeling abnormal 16.29 9.97 766 465137 141553 70320988
Stress 16.22 9.97 572 465331 67394 70395147
Spinal disorder 16.21 9.97 110 465793 9110 70453431
Lacrimal disorder 16.17 9.97 18 465885 473 70462068
Cardiotoxicity 16.16 9.97 30 465873 11040 70451501
Myocarditis 16.12 9.97 66 465837 18727 70443814
Frequent bowel movements 16.10 9.97 211 465692 20942 70441599
Coordination abnormal 16.03 9.97 53 465850 16013 70446528
Metastases to lung 16.03 9.97 55 465848 16429 70446112
Obstructive airways disorder 16.00 9.97 103 465800 26010 70436531
Dyslipidaemia 15.97 9.97 25 465878 9835 70452706
Neuropathy peripheral 15.95 9.97 676 465227 126220 70336321
Paranoia 15.93 9.97 59 465844 17229 70445312
Nephropathy toxic 15.90 9.97 65 465838 18449 70444092
Virologic failure 15.89 9.97 3 465900 3847 70458694
Bradypnoea 15.86 9.97 8 465895 5451 70457090
Finger deformity 15.84 9.97 81 465822 6055 70456486
Deformity 15.81 9.97 101 465802 8196 70454345
Generalised oedema 15.79 9.97 81 465822 21627 70440914
Body height below normal 15.76 9.97 37 465866 1858 70460683
Placental disorder 15.74 9.97 24 465879 866 70461675
Onychomycosis 15.71 9.97 88 465815 6813 70455728
Visual acuity reduced 15.71 9.97 113 465790 27817 70434724
Device leakage 15.66 9.97 23 465880 9285 70453256
Endophthalmitis 15.59 9.97 11 465892 6244 70456297
Gastroenteritis 15.59 9.97 290 465613 30923 70431618
Keratopathy 15.55 9.97 25 465878 945 70461596
Ankle arthroplasty 15.54 9.97 28 465875 1162 70461379
Heparin-induced thrombocytopenia 15.53 9.97 22 465881 9015 70453526
Cervical incompetence 15.50 9.97 18 465885 496 70462045
Renal tubular necrosis 15.45 9.97 89 465814 23082 70439459
Lipase increased 15.42 9.97 50 465853 15196 70447345
Hyperlactacidaemia 15.40 9.97 7 465896 5065 70457476
Cholangitis 15.39 9.97 33 465870 11516 70451025
Prostatic specific antigen increased 15.33 9.97 24 465879 9442 70453099
Vitamin B6 increased 15.31 9.97 6 465897 21 70462520
Breast cancer stage II 15.28 9.97 8 465895 5338 70457203
Drug hypersensitivity 15.28 9.97 1500 464403 260959 70201582
Hepatic encephalopathy 15.27 9.97 84 465819 22034 70440507
Haematocrit decreased 15.22 9.97 488 465415 56770 70405771
Bladder cancer 15.14 9.97 60 465843 17182 70445359
Cytomegalovirus chorioretinitis 15.04 9.97 8 465895 5290 70457251
Sickle cell anaemia 15.03 9.97 20 465883 635 70461906
Deep vein thrombosis postoperative 15.01 9.97 55 465848 3552 70458989
Delivery 15.01 9.97 19 465884 574 70461967
Haematuria 14.95 9.97 311 465592 63262 70399279
Transplant dysfunction 14.92 9.97 14 465889 6895 70455646
Hypophosphataemia 14.86 9.97 56 465847 16270 70446271
COVID-19 pneumonia 14.86 9.97 84 465819 21885 70440656
Tuberculin test positive 14.80 9.97 51 465852 3195 70459346
Genital haemorrhage 14.80 9.97 10 465893 5805 70456736
Product prescribing error 14.78 9.97 174 465729 38778 70423763
Lymphatic fistula 14.76 9.97 22 465881 778 70461763
Joint lock 14.76 9.97 48 465855 2919 70459622
Heart rate irregular 14.74 9.97 276 465627 29467 70433074
Atrioventricular block 14.73 9.97 39 465864 12649 70449892
Tooth disorder 14.72 9.97 230 465673 23708 70438833
End stage renal disease 14.68 9.97 32 465871 11101 70451440
Eosinophil count increased 14.66 9.97 51 465852 15171 70447370
Femoral hernia incarcerated 14.61 9.97 22 465881 785 70461756
Hypercapnia 14.59 9.97 20 465883 8309 70454232
Mental disorder 14.58 9.97 117 465786 28123 70434418
Bone density abnormal 14.47 9.97 47 465856 2856 70459685
Atrioventricular block complete 14.47 9.97 51 465852 15112 70447429
Mass 14.43 9.97 165 465738 15861 70446680
Injection site urticaria 14.43 9.97 128 465775 11510 70451031
Hypoxic-ischaemic encephalopathy 14.43 9.97 16 465887 7292 70455249
Toxic optic neuropathy 14.42 9.97 26 465877 1080 70461461
Breast abscess 14.37 9.97 28 465875 1234 70461307
Myopathy 14.37 9.97 68 465835 18544 70443997
Wound infection pseudomonas 14.36 9.97 32 465871 1552 70460989
Hepatic cytolysis 14.31 9.97 71 465832 19121 70443420
Accidental death 14.24 9.97 4 465899 3904 70458637
Glomerular filtration rate decreased 14.23 9.97 79 465824 20677 70441864
Hypothyroidism 14.22 9.97 213 465690 45542 70416999
Tooth infection 14.15 9.97 168 465735 16295 70446246
Renal injury 14.14 9.97 56 465847 16038 70446503
Peritoneal dialysis complication 14.10 9.97 40 465863 2256 70460285
Alcohol abuse 14.08 9.97 8 465895 5099 70457442
Intestinal ischaemia 14.07 9.97 37 465866 12027 70450514
Radiation inflammation 14.06 9.97 18 465885 550 70461991
Oesophageal carcinoma 14.01 9.97 25 465878 9341 70453200
Knee operation 14.01 9.97 68 465835 4979 70457562
Tooth abscess 13.95 9.97 152 465751 14437 70448104
Obesity 13.81 9.97 250 465653 26521 70436020
Spinal osteoarthritis 13.81 9.97 158 465745 15190 70447351
Tonsillitis 13.78 9.97 78 465825 6062 70456479
Gestational hypertension 13.74 9.97 34 465869 1766 70460775
Placental insufficiency 13.74 9.97 25 465878 1046 70461495
Purpura 13.69 9.97 66 465837 17909 70444632
Hydrocephalus 13.58 9.97 20 465883 8065 70454476
Skin exfoliation 13.56 9.97 231 465672 48395 70414146
Hypernatraemia 13.50 9.97 41 465862 12720 70449821
Ankylosing spondylitis 13.38 9.97 126 465777 11520 70451021
Maternal exposure during breast feeding 13.37 9.97 39 465864 2235 70460306
Incoherent 13.35 9.97 17 465886 7289 70455252
Arthropod bite 13.30 9.97 88 465815 7227 70455314
Hospitalisation 13.26 9.97 427 465476 82141 70380400
Alcohol interaction 13.25 9.97 7 465896 4646 70457895
Abortion threatened 13.22 9.97 15 465888 403 70462138
Ketoacidosis 13.19 9.97 17 465886 7252 70455289
Hypertriglyceridaemia 13.19 9.97 37 465866 11774 70450767
Hypervitaminosis 13.18 9.97 6 465897 33 70462508
Vitamin B6 deficiency 13.17 9.97 13 465890 296 70462245
Foot operation 13.16 9.97 65 465838 4792 70457749
Human anti-human antibody test 13.16 9.97 15 465888 405 70462136
Renal cancer 13.14 9.97 37 465866 11759 70450782
Aplasia 13.12 9.97 17 465886 7234 70455307
Polydipsia 13.09 9.97 12 465891 5976 70456565
Haemodialysis 13.09 9.97 64 465839 17302 70445239
Unevaluable event 13.05 9.97 252 465651 51811 70410730
Rebound effect 13.01 9.97 12 465891 5959 70456582
Blood glucose decreased 12.98 9.97 99 465804 24060 70438481
Brain natriuretic peptide increased 12.97 9.97 21 465882 8150 70454391
COVID-19 12.95 9.97 565 465338 105192 70357349
Hepatitis C 12.95 9.97 42 465861 12765 70449776
Cholestasis of pregnancy 12.91 9.97 23 465880 946 70461595
Lung transplant 12.90 9.97 6 465897 4284 70458257
Myelosuppression 12.90 9.97 131 465772 30014 70432527
Osteopenia 12.90 9.97 167 465736 16530 70446011
Toothache 12.86 9.97 181 465722 18249 70444292
Immune effector cell-associated neurotoxicity syndrome 12.86 9.97 5 465898 3973 70458568
Hepatitis E antibody positive 12.79 9.97 12 465891 256 70462285
Coronary artery bypass 12.78 9.97 12 465891 5908 70456633
Alanine aminotransferase increased 12.76 9.97 816 465087 146664 70315877
Mycobacterium tuberculosis complex test positive 12.76 9.97 39 465864 2294 70460247
Anti-neutrophil cytoplasmic antibody positive vasculitis 12.73 9.97 3 465900 3294 70459247
Hyperlipidaemia 12.72 9.97 98 465805 23765 70438776
Joint warmth 12.70 9.97 30 465873 1512 70461029
Pancreatic steatosis 12.66 9.97 24 465879 1036 70461505
Hepatic cyst 12.65 9.97 71 465832 5500 70457041
Hepatitis acute 12.64 9.97 48 465855 13914 70448627
Antibody test positive 12.64 9.97 41 465862 2490 70460051
Colitis microscopic 12.62 9.97 25 465878 8980 70453561
Neck pain 12.61 9.97 547 465356 66110 70396431
Arthritis bacterial 12.61 9.97 95 465808 8138 70454403
Iodine allergy 12.61 9.97 17 465886 547 70461994
Blood folate increased 12.57 9.97 16 465887 486 70462055
Ventricular arrhythmia 12.54 9.97 20 465883 7810 70454731
Immunosuppression 12.54 9.97 123 465780 11369 70451172
Left ventricular dysfunction 12.50 9.97 68 465835 17889 70444652
Metastasis 12.50 9.97 13 465890 6101 70456440
Complication of device insertion 12.49 9.97 10 465893 5322 70457219
Eye infection 12.40 9.97 111 465792 10007 70452534
Immune thrombocytopenia 12.39 9.97 60 465843 16264 70446277
Memory impairment 12.39 9.97 490 465413 92151 70370390
Small for dates baby 12.35 9.97 15 465888 434 70462107
Injection site extravasation 12.33 9.97 99 465804 8647 70453894
Respiratory tract infection viral 12.30 9.97 51 465852 3490 70459051
Accessory spleen 12.29 9.97 10 465893 175 70462366
Personality disorder 12.27 9.97 11 465892 5537 70457004
Oesophageal fibrosis 12.25 9.97 10 465893 176 70462365
Epistaxis 12.22 9.97 550 465353 102077 70360464
Metastases to central nervous system 12.16 9.97 54 465849 14980 70447561
Amylase increased 12.14 9.97 31 465872 10177 70452364
Renal disorder 12.14 9.97 176 465727 37833 70424708
Multiple drug therapy 12.13 9.97 3 465900 3189 70459352
Lethargy 12.12 9.97 389 465514 74861 70387680
Clear cell renal cell carcinoma 12.06 9.97 38 465865 2272 70460269
Multiple sclerosis 12.05 9.97 107 465796 25178 70437363
Atrial flutter 12.04 9.97 81 465822 20246 70442295
Status epilepticus 12.03 9.97 103 465800 24423 70438118
Diaphragmatic disorder 12.03 9.97 30 465873 1566 70460975
Acute graft versus host disease in intestine 12.01 9.97 5 465898 3811 70458730
Injection site haemorrhage 12.01 9.97 235 465668 25292 70437249
Osteoporotic fracture 11.99 9.97 53 465850 3731 70458810
Oxygen consumption increased 11.97 9.97 8 465895 4672 70457869
Therapy non-responder 11.96 9.97 619 465284 76296 70386245
Catheter site erythema 11.95 9.97 9 465894 4939 70457602
Hypoalbuminaemia 11.93 9.97 75 465828 19047 70443494
Sinus congestion 11.88 9.97 170 465733 17203 70445338
Hepatic cancer 11.83 9.97 29 465874 9654 70452887
Metastases to meninges 11.82 9.97 3 465900 3133 70459408
Capillary leak syndrome 11.79 9.97 4 465899 3458 70459083
Motor dysfunction 11.79 9.97 45 465858 13025 70449516
Hypoglycaemic coma 11.78 9.97 7 465896 4354 70458187
Drug specific antibody 11.78 9.97 38 465865 2301 70460240
Photophobia 11.77 9.97 180 465723 18470 70444071
Hepatitis cholestatic 11.77 9.97 43 465860 12607 70449934
Lymphocyte count decreased 11.77 9.97 208 465695 43331 70419210
Anal fistula 11.75 9.97 74 465829 5976 70456565
Device related infection 11.74 9.97 145 465758 32040 70430501
Acute lymphocytic leukaemia recurrent 11.74 9.97 9 465894 4895 70457646
Immune-mediated myositis 11.71 9.97 3 465900 3113 70459428
Pleural fibrosis 11.65 9.97 56 465847 4083 70458458
Haemodynamic instability 11.63 9.97 58 465845 15600 70446941
Kidney infection 11.61 9.97 186 465717 19269 70443272
Blood loss anaemia 11.60 9.97 52 465851 14389 70448152
Pneumonia bacterial 11.60 9.97 63 465840 16578 70445963
Hypocalcaemia 11.59 9.97 216 465687 44643 70417898
Drug tolerance 11.54 9.97 86 465817 7342 70455199
Pneumonia aspiration 11.53 9.97 316 465587 61973 70400568
Uterine perforation 11.52 9.97 13 465890 5878 70456663
Aphthous ulcer 11.49 9.97 147 465756 14509 70448032
Lower respiratory tract congestion 11.49 9.97 48 465855 3296 70459245
Nail injury 11.47 9.97 16 465887 532 70462009
Tendon disorder 11.43 9.97 78 465825 6473 70456068
Abortion incomplete 11.41 9.97 3 465900 3059 70459482
Salivary hypersecretion 11.34 9.97 45 465858 12880 70449661
Personality change 11.29 9.97 26 465877 8844 70453697
Anger 11.28 9.97 61 465842 16071 70446470
Stress at work 11.25 9.97 23 465880 1050 70461491
Parkinsonism 11.25 9.97 57 465846 15268 70447273
Myofascial pain syndrome 11.22 9.97 32 465871 1810 70460731
Defaecation disorder 11.22 9.97 17 465886 610 70461931
Pharyngitis 11.20 9.97 192 465711 20159 70442382
Diabetes mellitus inadequate control 11.16 9.97 95 465808 22550 70439991
Post procedural haemorrhage 11.15 9.97 45 465858 12821 70449720
Bronchial secretion retention 11.12 9.97 3 465900 3007 70459534
Product preparation error 11.11 9.97 8 465895 4494 70458047
Laryngospasm 11.10 9.97 5 465898 3638 70458903
Dermatitis atopic 10.98 9.97 27 465876 8980 70453561
Hepatic cirrhosis 10.98 9.97 272 465631 30459 70432082
C-reactive protein decreased 10.98 9.97 38 465865 2386 70460155
Postpartum haemorrhage 10.97 9.97 28 465875 1483 70461058
Euglycaemic diabetic ketoacidosis 10.95 9.97 14 465889 5993 70456548
Anticholinergic syndrome 10.95 9.97 3 465900 2977 70459564
Congestive cardiomyopathy 10.93 9.97 36 465867 10890 70451651
Diabetes mellitus 10.93 9.97 374 465529 71450 70391091
Dermatitis allergic 10.92 9.97 160 465743 16271 70446270
Systemic inflammatory response syndrome 10.92 9.97 35 465868 10677 70451864
Skin ulcer haemorrhage 10.91 9.97 15 465888 492 70462049
Embolism 10.90 9.97 46 465857 12942 70449599
Ileus paralytic 10.89 9.97 26 465877 8735 70453806
Umbilical hernia 10.89 9.97 65 465838 5151 70457390
Sleep disorder due to a general medical condition 10.84 9.97 34 465869 10442 70452099
Cellulitis 10.84 9.97 772 465131 98156 70364385
Jaundice cholestatic 10.84 9.97 28 465875 9156 70453385
Dermatitis bullous 10.82 9.97 45 465858 12712 70449829
Type 1 diabetes mellitus 10.80 9.97 15 465888 6199 70456342
Hypophagia 10.79 9.97 200 465703 41370 70421171
Threatened labour 10.77 9.97 16 465887 564 70461977
Tooth fracture 10.76 9.97 112 465791 10515 70452026
Skin neoplasm excision 10.72 9.97 21 465882 929 70461612
Depressed mood 10.71 9.97 213 465690 43607 70418934
Vacuum extractor delivery 10.70 9.97 8 465895 123 70462418
Nephrotic syndrome 10.69 9.97 35 465868 10605 70451936
Complication associated with device 10.67 9.97 60 465843 15653 70446888
Angina unstable 10.62 9.97 61 465842 15832 70446709
Inadequate analgesia 10.61 9.97 7 465896 4115 70458426
Pulmonary pain 10.60 9.97 48 465855 3414 70459127
Labyrinthitis 10.55 9.97 41 465862 2723 70459818
Intestinal stenosis 10.55 9.97 47 465856 3320 70459221
Device occlusion 10.54 9.97 35 465868 10560 70451981
Sensitivity to weather change 10.54 9.97 84 465819 7321 70455220
Anticonvulsant drug level above therapeutic 10.42 9.97 23 465880 1108 70461433
Osteonecrosis 10.40 9.97 132 465771 29028 70433513
Hernia 10.40 9.97 146 465757 14714 70447827
Skin graft failure 10.37 9.97 10 465893 221 70462320
Pneumothorax 10.37 9.97 114 465789 25732 70436809
Swollen joint count 10.37 9.97 21 465882 952 70461589
Plasma cell myeloma recurrent 10.37 9.97 8 465895 4338 70458203
Panic attack 10.36 9.97 94 465809 22025 70440516
Disturbance in social behaviour 10.34 9.97 7 465896 4060 70458481
Mean cell volume increased 10.32 9.97 68 465835 5576 70456965
Investigation abnormal 10.32 9.97 31 465872 1806 70460735
Dry skin 10.28 9.97 284 465619 55647 70406894
Cytomegalovirus infection reactivation 10.23 9.97 18 465885 6763 70455778
Faecal calprotectin increased 10.21 9.97 57 465846 4408 70458133
Liver injury 10.20 9.97 347 465556 40688 70421853
Transaminases increased 10.19 9.97 233 465670 46785 70415756
Hepatitis E virus test positive 10.16 9.97 11 465892 280 70462261
Anal fissure 10.16 9.97 73 465830 6160 70456381
Ligament rupture 10.12 9.97 42 465861 2875 70459666
Musculoskeletal discomfort 10.09 9.97 169 465734 17663 70444878
Mesothelioma 10.02 9.97 12 465891 342 70462199
Cholecystitis chronic 10.01 9.97 30 465873 9346 70453195
Rash pruritic 10.01 9.97 508 465395 62483 70400058
Liver transplant 9.99 9.97 8 465895 4258 70458283

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A11HA02 ALIMENTARY TRACT AND METABOLISM
VITAMINS
OTHER PLAIN VITAMIN PREPARATIONS
Other plain vitamin preparations
ATC J04AM08 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIMYCOBACTERIALS
DRUGS FOR TREATMENT OF TUBERCULOSIS
Combinations of drugs for treatment of tuberculosis
FDA Chemical/Ingredient N0000005657 Vitamin B 6
FDA Chemical/Ingredient N0000175452 Analogs/Derivatives
MeSH PA D018977 Micronutrients
MeSH PA D014803 Vitamin B Complex
MeSH PA D014815 Vitamins
FDA EPC N0000192800 Vitamin B6 Analog
CHEBI has role CHEBI:23357 cofactor
CHEBI has role CHEBI:75771 Mus musculus metabolites
CHEBI has role CHEBI:75772 S. cerevisiae metabolites
CHEBI has role CHEBI:76971 Escherichia coli metabolites
CHEBI has role CHEBI:77746 Homo sapiens metabolite

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Pregnancy, function indication 289908002
Vitamin B6 deficiency indication 386080007 DOID:8455
Breastfeeding (mother) indication 413712001
Drug-Induced Pyridoxine Deficiency indication
Pyridoxine-Dependent Seizure indication
Nutritional disorder contraindication 2492009 DOID:374
Alcoholism contraindication 7200002
Peptic ulcer contraindication 13200003 DOID:750
Hyperkalemia contraindication 14140009
Gastroenteritis contraindication 25374005 DOID:2326
Dehydration contraindication 34095006
Depressive disorder contraindication 35489007
Acute hepatitis contraindication 37871000
Hemosiderosis contraindication 39011001 DOID:12119
Hypokalemia contraindication 43339004
Chronic heart failure contraindication 48447003
Gastrectomy contraindication 53442002
Systemic lupus erythematosus contraindication 55464009 DOID:9074
Schizophrenia contraindication 58214004 DOID:5419
Acute nephropathy contraindication 58574008
Leber's optic atrophy contraindication 58610003 DOID:705
Metabolic acidosis contraindication 59455009
Hepatic failure contraindication 59927004
Hemolytic anemia contraindication 61261009 DOID:583
Diarrhea contraindication 62315008
Ulcerative colitis contraindication 64766004 DOID:8577
Poisoning by acetaminophen contraindication 70273001
Diabetes mellitus contraindication 73211009 DOID:9351
Gastrointestinal hemorrhage contraindication 74474003
Atrophic gastritis contraindication 84568007 DOID:8929
Autoimmune disease contraindication 85828009
Gout contraindication 90560007 DOID:13189
Kidney disease contraindication 90708001 DOID:557
Anemia due to enzyme deficiency contraindication 111577008
Gastrointestinal obstruction contraindication 126765001
Acute hepatic failure contraindication 197270009
Impaired renal function disorder contraindication 197663003
Gastroparesis contraindication 235675006
Disease of liver contraindication 235856003 DOID:409
Rhabdomyolysis contraindication 240131006
Esophageal dysmotility contraindication 266434009 DOID:9192
Diabetic - poor control contraindication 268519009
Peripheral nerve disease contraindication 302226006
Primary adrenocortical insufficiency contraindication 373662000
Diverticular disease contraindication 397881000
Hemochromatosis contraindication 399187006 DOID:2352
Ketoacidosis in diabetes mellitus contraindication 420422005 DOID:1837
Diabetic peripheral neuropathy contraindication 424736006
Slow acetylator due to N-acetyltransferase enzyme variant contraindication 425079005
Chronic Hepatic Disease contraindication
Genitourinary Tract Infections contraindication
Repeated Blood Transfusions contraindication
Prolonged-Severe Nausea and Vomiting contraindication
Esophageal Compression contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 8.98 acidic
pKa2 13.8 acidic
pKa3 4.94 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
20MG;20MG BONJESTA DUCHESNAY N209661 Nov. 7, 2016 RX TABLET, EXTENDED RELEASE ORAL 9089489 Feb. 18, 2033 TREATMENT OF NAUSEA AND VOMITING OF PREGNANCY IN WOMEN WHO DO NOT RESPOND TO CONSERVATIVE MANAGEMENT
20MG;20MG BONJESTA DUCHESNAY N209661 Nov. 7, 2016 RX TABLET, EXTENDED RELEASE ORAL 9375404 Feb. 18, 2033 TREATMENT OF NAUSEA AND VOMITING OF PREGNANCY IN WOMEN WHO DO NOT RESPOND TO CONSERVATIVE MANAGEMENT
20MG;20MG BONJESTA DUCHESNAY N209661 Nov. 7, 2016 RX TABLET, EXTENDED RELEASE ORAL 9526703 Feb. 18, 2033 TREATMENT OF NAUSEA AND VOMITING OF PREGNANCY IN WOMEN WHO DO NOT RESPOND TO CONSERVATIVE MANAGEMENT
20MG;20MG BONJESTA DUCHESNAY N209661 Nov. 7, 2016 RX TABLET, EXTENDED RELEASE ORAL 9937132 Feb. 18, 2033 TREATMENT OF NAUSEA AND VOMITING OF PREGNANCY IN WOMEN WHO DO NOT RESPOND TO CONSERVATIVE MANAGEMENT

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Serine hydroxymethyltransferase, cytosolic Enzyme WOMBAT-PK
Pyridoxine-5'-phosphate oxidase Enzyme WOMBAT-PK
Pyridoxal phosphate phosphatase Enzyme WOMBAT-PK
Pyridoxal kinase Kinase WOMBAT-PK
Cystathionine beta-synthase Enzyme WOMBAT-PK
Phosphoserine aminotransferase Enzyme WOMBAT-PK

External reference:

IDSource
4019922 VUID
N0000148007 NUI
D02179 KEGG_DRUG
58-56-0 SECONDARY_CAS_RN
4017489 VANDF
4017779 VANDF
4018569 VANDF
4019922 VANDF
4021899 VANDF
C0034272 UMLSCUI
CHEBI:16709 CHEBI
UEG PDB_CHEM_ID
CHEMBL1364 ChEMBL_ID
DB00165 DRUGBANK_ID
CHEMBL1200756 ChEMBL_ID
D011736 MESH_DESCRIPTOR_UI
1054 PUBCHEM_CID
2216 INN_ID
KV2JZ1BI6Z UNII
203164 RXNORM
35074 MMSL
4979 MMSL
4994 MMSL
5393 MMSL
5686 MMSL
6601 MMSL
d00412 MMSL
001058 NDDF
004538 NDDF
126227009 SNOMEDCT_US
430469009 SNOMEDCT_US
767286000 SNOMEDCT_US
D025101 MESH_DESCRIPTOR_UI

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
NataFort HUMAN PRESCRIPTION DRUG LABEL 10 0178-0716 TABLET 10 mg ORAL Unapproved drug other 12 sections
CitraNatal Harmony 3.0 HUMAN PRESCRIPTION DRUG LABEL 8 0178-0796 CAPSULE, GELATIN COATED 25 mg ORAL unapproved drug other 10 sections
CitraNatal Harmony 3.0 HUMAN PRESCRIPTION DRUG LABEL 8 0178-0796 CAPSULE, GELATIN COATED 25 mg ORAL unapproved drug other 10 sections
CitraNatal Harmony HUMAN PRESCRIPTION DRUG LABEL 8 0178-0798 CAPSULE, GELATIN COATED 25 mg ORAL UNAPPROVED DRUG OTHER 11 sections
CitraNatal Harmony HUMAN PRESCRIPTION DRUG LABEL 8 0178-0799 CAPSULE, GELATIN COATED 25 mg ORAL Unapproved drug other 11 sections
CitraNatal Harmony HUMAN PRESCRIPTION DRUG LABEL 8 0178-0812 CAPSULE, GELATIN COATED 25 mg ORAL Unapproved drug other 11 sections
CitraNatal 90 DHA HUMAN PRESCRIPTION DRUG LABEL 16 0178-0821 TABLET 20 mg ORAL unapproved drug other 11 sections
CitraNatal 90 DHA HUMAN PRESCRIPTION DRUG LABEL 16 0178-0821 TABLET 20 mg ORAL unapproved drug other 11 sections
CitraNatal 90 DHA HUMAN OTC DRUG LABEL 14 0178-0829 TABLET 20 mg ORAL Unapproved drug other 11 sections
CitraNatal Rx HUMAN PRESCRIPTION DRUG LABEL 13 0178-0858 TABLET 20 mg ORAL Unapproved drug other 12 sections
CitraNatal Rx HUMAN PRESCRIPTION DRUG LABEL 14 0178-0859 TABLET 20 mg ORAL Unapproved drug other 9 sections
CitraNatal Medley HUMAN PRESCRIPTION DRUG LABEL 8 0178-0896 CAPSULE, GELATIN COATED 12.50 mg ORAL unapproved drug other 10 sections
CitraNatal DHA HUMAN OTC DRUG LABEL 14 0178-0898 TABLET 20 mg ORAL Unapproved drug other 11 sections
Doxylamine Succinate and Pyridoxine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 2 0378-4615 TABLET, DELAYED RELEASE 10 mg ORAL ANDA 26 sections
Doxylamine succinate and pyridoxine hydrochloride HUMAN PRESCRIPTION DRUG LABEL 2 0591-2132 TABLET, DELAYED RELEASE 10 mg ORAL ANDA 25 sections
Doxylamine succinate and pyridoxine hydrochloride HUMAN PRESCRIPTION DRUG LABEL 2 0591-2132 TABLET, DELAYED RELEASE 10 mg ORAL ANDA 25 sections
VitafolOne HUMAN PRESCRIPTION DRUG LABEL 16 0642-0070 CAPSULE, GELATIN COATED 2.50 mg ORAL unapproved drug other 14 sections
Vitafol Caplet HUMAN PRESCRIPTION DRUG LABEL 12 0642-0072 CAPSULE 15 mg ORAL UNAPPROVED DRUG OTHER 13 sections
Select OB HUMAN PRESCRIPTION DRUG LABEL 15 0642-0077 TABLET, CHEWABLE 2.50 mg ORAL UNAPPROVED DRUG OTHER 14 sections
Vitafol OB Caplet HUMAN PRESCRIPTION DRUG LABEL 15 0642-0079 TABLET 2.50 mg ORAL Unapproved drug other 14 sections
Vitafol Plus HUMAN PRESCRIPTION DRUG LABEL 17 0642-0092 CAPSULE, LIQUID FILLED 2.50 mg ORAL UNAPPROVED DRUG OTHER 13 sections
Vitafol Ultra HUMAN PRESCRIPTION DRUG LABEL 17 0642-0093 CAPSULE, LIQUID FILLED 2.50 mg ORAL UNAPPROVED DRUG OTHER 13 sections
Vitafol Nano HUMAN PRESCRIPTION DRUG LABEL 7 0642-0094 TABLET, COATED 2.50 mg ORAL UNAPPROVED DRUG OTHER 14 sections
Select OB HUMAN PRESCRIPTION DRUG LABEL 15 0642-0120 TABLET, CHEWABLE 2.50 mg ORAL UNAPPROVED DRUG OTHER 13 sections
Strovite Forte Caplet HUMAN PRESCRIPTION DRUG LABEL 19 0642-0204 TABLET, COATED 25 mg ORAL UNAPPROVED DRUG OTHER 15 sections
Strovite One Caplets HUMAN PRESCRIPTION DRUG LABEL 20 0642-0207 TABLET 25 mg ORAL UNAPPROVED DRUG OTHER 14 sections
Reaphirm Plant Source DHA HUMAN PRESCRIPTION DRUG LABEL 16 0642-3010 CAPSULE, GELATIN COATED 2.50 mg ORAL unapproved drug other 7 sections
Vitafol HUMAN PRESCRIPTION DRUG LABEL 4 0642-7468 STRIP 2.50 mg ORAL Unapproved drug other 13 sections
Vitafol Fe Plus HUMAN PRESCRIPTION DRUG LABEL 17 0642-7473 CAPSULE, LIQUID FILLED 2.50 mg ORAL UNAPPROVED DRUG OTHER 14 sections
Marnatal F HUMAN PRESCRIPTION DRUG LABEL 13 0682-1570 CAPSULE 5 mg ORAL UNAPPROVED DRUG OTHER 4 sections