riboflavin ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
2834 83-88-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • riboflavine
  • beflavine
  • lactoflavin
  • lactoflavine
  • Vitamin B2
  • riboflavin (vit B2)
  • riboflavin
Nutritional factor found in milk, eggs, malted barley, liver, kidney, heart, and leafy vegetables. The richest natural source is yeast. It occurs in the free form only in the retina of the eye, in whey, and in urine; its principal forms in tissues and cells are as FLAVIN MONONUCLEOTIDE and FLAVIN-ADENINE DINUCLEOTIDE.
  • Molecular weight: 376.37
  • Formula: C17H20N4O6
  • CLOGP: -0.73
  • LIPINSKI: 0
  • HAC: 10
  • HDO: 5
  • TPSA: 155.05
  • ALOGS: -2.76
  • ROTB: 5

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

None

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 4 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 0.11 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 75 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 1.33 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD

Approvals:

DateAgencyCompanyOrphan
Feb. 20, 1953 FDA HOSPIRA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pemphigus 1625.33 10.23 3082 374679 117084 50110279
Systemic lupus erythematosus 1512.15 10.23 3279 374482 137343 50090020
Glossodynia 1303.13 10.23 2748 375013 112821 50114542
Rheumatoid arthritis 1056.55 10.23 3618 374143 198932 50028431
Hand deformity 1037.01 10.23 2302 375459 97897 50129466
Arthropathy 931.74 10.23 2942 374819 154964 50072399
Maternal exposure during pregnancy 930.11 10.23 2963 374798 156815 50070548
Alopecia 912.85 10.23 3933 373828 241114 49986249
Abdominal discomfort 896.13 10.23 3761 374000 227880 49999483
Wound 847.33 10.23 2201 375560 103593 50123770
Completed suicide 741.29 10.23 66 377695 131823 50095540
Infusion related reaction 675.31 10.23 2779 374982 166778 50060585
Synovitis 672.51 10.23 2244 375517 121621 50105742
Pericarditis 645.13 10.23 1652 376109 77037 50150326
Anti-cyclic citrullinated peptide antibody positive 634.54 10.23 1535 376226 69052 50158311
Contraindicated product administered 621.33 10.23 2477 375284 146481 50080882
Discomfort 608.36 10.23 1986 375775 106394 50120969
Swelling 580.86 10.23 2997 374764 197875 50029488
Joint swelling 566.26 10.23 3444 374317 241842 49985521
Pain 556.92 10.23 6677 371084 572226 49655137
Toxicity to various agents 548.66 10.23 468 377293 212031 50015332
Death 455.95 10.23 1105 376656 324274 49903089
Product use issue 393.33 10.23 2174 375587 147301 50080062
Rheumatoid factor positive 388.15 10.23 1027 376734 48832 50178531
Duodenal ulcer perforation 365.77 10.23 950 376811 44661 50182702
Arthralgia 362.32 10.23 4923 372838 433779 49793584
Helicobacter infection 354.15 10.23 991 376770 48711 50178652
Drug interaction 340.84 10.23 605 377156 199016 50028347
Hepatic enzyme increased 321.44 10.23 1937 375824 135443 50091920
Drug abuse 320.30 10.23 36 377725 59810 50167553
Intentional overdose 305.14 10.23 50 377711 62454 50164909
Exposure during pregnancy 280.95 10.23 1703 376058 119312 50108051
Drug intolerance 248.04 10.23 2613 375148 216491 50010872
Musculoskeletal stiffness 246.26 10.23 1723 376038 126758 50100605
Hip arthroplasty 246.19 10.23 636 377125 29793 50197570
Therapeutic product effect decreased 234.07 10.23 1778 375983 134272 50093091
Treatment failure 230.25 10.23 1787 375974 135850 50091513
Knee arthroplasty 225.76 10.23 684 377077 35162 50192201
Febrile neutropenia 217.21 10.23 245 377516 97422 50129941
Overdose 208.11 10.23 263 377498 99464 50127899
Acute kidney injury 194.35 10.23 958 376803 227100 50000263
Suicide attempt 193.37 10.23 72 377689 51660 50175703
Psoriatic arthropathy 191.58 10.23 777 376984 46255 50181108
Nasopharyngitis 190.46 10.23 2240 375521 190687 50036676
Cardiac arrest 184.74 10.23 211 377550 83440 50143923
Depressed level of consciousness 178.53 10.23 82 377679 51871 50175492
Red blood cell sedimentation rate abnormal 167.06 10.23 374 377387 15969 50211394
Hypersensitivity 161.33 10.23 2376 375385 212785 50014578
Malignant neoplasm progression 157.97 10.23 165 377596 67959 50159404
Diarrhoea 155.14 10.23 3284 374477 585192 49642171
Disease progression 154.18 10.23 301 377460 95565 50131798
C-reactive protein abnormal 151.65 10.23 505 377256 27304 50200059
Drug hypersensitivity 149.66 10.23 1178 376583 249832 49977531
Device expulsion 147.69 10.23 20 377741 28802 50198561
Impaired healing 144.38 10.23 954 376807 68832 50158531
Drug ineffective 142.12 10.23 7469 370292 811864 49415499
Constipation 141.48 10.23 810 376951 184898 50042465
Rheumatic fever 139.99 10.23 356 377405 16511 50210852
Nausea 139.07 10.23 4110 373651 701288 49526075
Swollen joint count increased 135.16 10.23 325 377436 14548 50212815
Bradycardia 133.24 10.23 171 377590 64255 50163108
Sickle cell anaemia with crisis 131.58 10.23 166 377595 4377 50222986
Neutropenia 131.51 10.23 612 377149 147353 50080010
Lactic acidosis 128.79 10.23 44 377717 33311 50194052
Cardiac failure 126.42 10.23 234 377527 75806 50151557
Sedation 126.02 10.23 36 377725 30574 50196789
Hyponatraemia 124.61 10.23 339 377422 95800 50131563
Asthenia 123.11 10.23 1660 376101 317382 49909981
Tremor 118.98 10.23 448 377313 114455 50112908
Electrocardiogram QT prolonged 114.40 10.23 131 377630 51755 50175608
Anxiety 113.61 10.23 817 376944 176789 50050574
Hypotension 110.76 10.23 1173 376588 234296 49993067
Pregnancy 110.54 10.23 476 377285 29101 50198262
Fatigue 110.46 10.23 6390 371371 701211 49526152
Dyspnoea 109.57 10.23 3183 374578 544425 49682938
Somnolence 107.53 10.23 696 377065 154289 50073074
Dizziness 105.86 10.23 1884 375877 344485 49882878
Agitation 104.99 10.23 147 377614 53237 50174126
Vomiting 104.37 10.23 2631 375130 458127 49769236
Respiratory arrest 103.66 10.23 47 377714 29962 50197401
Renal failure 103.24 10.23 427 377334 106206 50121157
Rash 102.22 10.23 4112 373649 433359 49794004
Sleep disorder due to general medical condition, insomnia type 101.04 10.23 484 377277 30963 50196400
Muscle injury 98.88 10.23 542 377219 36569 50190794
Psoriasis 98.67 10.23 865 376896 68135 50159228
Folliculitis 98.63 10.23 564 377197 38661 50188702
Live birth 96.70 10.23 306 377455 16102 50211261
Arthritis 96.36 10.23 1031 376730 85690 50141673
Abortion spontaneous 93.11 10.23 582 377179 41190 50186173
Lower respiratory tract infection 92.74 10.23 1103 376658 94098 50133265
Drug reaction with eosinophilia and systemic symptoms 91.40 10.23 49 377712 28375 50198988
Sopor 90.36 10.23 19 377742 19860 50207503
Rhabdomyolysis 89.93 10.23 95 377666 38932 50188431
Multiple sclerosis relapse 89.90 10.23 113 377648 42851 50184512
Intentional self-injury 88.34 10.23 31 377730 23081 50204282
Blister 88.25 10.23 1001 376760 84417 50142946
Osteoarthritis 87.92 10.23 840 376921 67766 50159597
Neoplasm progression 87.03 10.23 55 377706 29102 50198261
Neuropathy peripheral 84.27 10.23 403 377358 96354 50131009
Hyperhidrosis 82.92 10.23 364 377397 89062 50138301
Condition aggravated 81.45 10.23 2843 374918 294215 49933148
Injection site erythema 80.06 10.23 884 376877 74052 50153311
Cardio-respiratory arrest 80.04 10.23 177 377584 53715 50173648
Drug withdrawal syndrome 76.68 10.23 46 377715 25035 50202328
Blood pressure fluctuation 75.44 10.23 492 377269 35331 50192032
Hypoglycaemia 74.73 10.23 182 377579 53399 50173964
Drug dependence 74.67 10.23 27 377734 19732 50207631
Tachycardia 74.36 10.23 438 377323 99325 50128038
Syncope 73.74 10.23 458 377303 102544 50124819
Myalgia 73.70 10.23 584 377177 123735 50103628
Irritable bowel syndrome 72.56 10.23 643 377118 50798 50176565
Anaemia 72.39 10.23 1388 376373 251068 49976295
Hypoxia 71.03 10.23 174 377587 50949 50176414
Serotonin syndrome 70.54 10.23 49 377712 24664 50202699
Encephalopathy 70.18 10.23 89 377672 33622 50193741
Joint effusion 69.69 10.23 235 377526 12786 50214577
Cognitive disorder 69.64 10.23 140 377621 43983 50183380
Product quality issue 69.01 10.23 77 377684 30781 50196582
Renal impairment 68.92 10.23 310 377451 75351 50152012
Injection site pruritus 68.74 10.23 527 377234 39884 50187479
Palmar-plantar erythrodysaesthesia syndrome 68.61 10.23 32 377729 20066 50207297
Hepatic failure 68.49 10.23 84 377677 32199 50195164
Coma 67.52 10.23 209 377552 56670 50170693
Insomnia 67.25 10.23 910 376851 173955 50053408
Contusion 66.08 10.23 1191 376570 110992 50116371
Hyperglycaemia 66.00 10.23 106 377655 36299 50191064
Respiratory failure 64.97 10.23 406 377355 90775 50136588
Caesarean section 64.95 10.23 260 377501 15379 50211984
Sinusitis 64.04 10.23 1697 376064 168861 50058502
Disability assessment scale score increased 63.33 10.23 83 377678 2275 50225088
Juvenile idiopathic arthritis 63.28 10.23 92 377669 2787 50224576
Metabolic acidosis 63.17 10.23 121 377640 38704 50188659
Drug resistance 62.14 10.23 32 377729 18957 50208406
Basal cell carcinoma 62.14 10.23 341 377420 23015 50204348
No adverse event 61.60 10.23 97 377664 33481 50193882
Thrombocytopenia 61.17 10.23 633 377128 127040 50100323
Intentional product misuse 61.12 10.23 164 377597 46570 50180793
Red blood cell sedimentation rate increased 60.72 10.23 402 377359 29014 50198349
Hepatic function abnormal 59.39 10.23 95 377666 32586 50194777
Asthma 59.00 10.23 407 377354 88930 50138433
Cardiac failure congestive 58.95 10.23 378 377383 84004 50143359
Urticaria 58.20 10.23 652 377109 128909 50098454
Multiple organ dysfunction syndrome 57.62 10.23 188 377573 50149 50177214
Blood glucose increased 57.01 10.23 306 377455 71018 50156345
Feeling abnormal 56.57 10.23 631 377130 124861 50102502
Foot deformity 56.26 10.23 288 377473 18922 50208441
Joint laxity 56.19 10.23 79 377682 2319 50225044
Balance disorder 55.79 10.23 304 377457 70286 50157077
Ill-defined disorder 55.76 10.23 639 377122 54015 50173348
Diabetic ketoacidosis 55.74 10.23 32 377729 17840 50209523
Altered state of consciousness 54.32 10.23 50 377711 21860 50205503
Injection site swelling 54.26 10.23 513 377248 41260 50186103
Cholestasis 53.98 10.23 66 377695 25335 50202028
Muscle spasms 53.60 10.23 639 377122 124914 50102449
Sedation complication 53.20 10.23 3 377758 8763 50218600
Blood cholesterol increased 52.98 10.23 638 377123 54577 50172786
Injection site reaction 52.87 10.23 589 377172 49443 50177920
Blood pressure diastolic abnormal 52.82 10.23 172 377589 9189 50218174
Fluid retention 52.70 10.23 197 377564 50452 50176911
Fibromyalgia 52.41 10.23 540 377221 44438 50182925
Orthostatic hypotension 52.36 10.23 87 377674 29394 50197969
Pulmonary embolism 52.15 10.23 496 377265 101208 50126155
Injection site pain 52.05 10.23 1139 376622 109885 50117478
Peripheral swelling 51.96 10.23 1953 375808 203983 50023380
Osteoporosis 51.91 10.23 538 377223 44341 50183022
Foetal exposure during pregnancy 51.78 10.23 366 377395 26993 50200370
Mental status changes 51.53 10.23 122 377639 36150 50191213
Hallucination 51.52 10.23 177 377584 46480 50180883
Seizure 51.05 10.23 598 377163 117276 50110087
Respiratory disorder 50.91 10.23 97 377664 31090 50196273
Muscle spasticity 50.49 10.23 33 377728 17151 50210212
Hypokalaemia 50.45 10.23 417 377344 87575 50139788
Grip strength decreased 49.93 10.23 201 377560 11920 50215443
Dehydration 49.73 10.23 819 376942 151630 50075733
Hepatocellular injury 49.48 10.23 73 377688 25874 50201489
Cytomegalovirus infection 49.46 10.23 37 377724 17925 50209438
Disturbance in attention 49.17 10.23 99 377662 31087 50196276
Vision blurred 49.16 10.23 364 377397 78283 50149080
Weight increased 48.64 10.23 1905 375856 199986 50027377
Type 2 diabetes mellitus 48.63 10.23 430 377331 33945 50193418
Premature labour 47.83 10.23 191 377570 11285 50216078
Emotional distress 47.80 10.23 88 377673 28575 50198788
Chest discomfort 47.62 10.23 452 377309 92270 50135093
Decreased appetite 47.56 10.23 1139 376622 199784 50027579
Bone erosion 47.50 10.23 193 377568 11494 50215869
Metastases to bone 47.11 10.23 39 377722 17956 50209407
Restlessness 46.86 10.23 72 377689 25101 50202262
Mydriasis 46.60 10.23 11 377750 10616 50216747
Loss of personal independence in daily activities 46.41 10.23 758 377003 69292 50158071
Blood pressure systolic increased 45.87 10.23 435 377326 35014 50192349
Depression 45.39 10.23 916 376845 164507 50062856
Poisoning 45.27 10.23 18 377743 12411 50214952
Pulmonary arterial hypertension 45.11 10.23 51 377710 20268 50207095
Ejection fraction decreased 45.04 10.23 43 377718 18477 50208886
Loss of consciousness 44.96 10.23 530 377231 103823 50123540
Anaphylactic reaction 44.83 10.23 229 377532 53826 50173537
Blood pressure systolic abnormal 44.76 10.23 143 377618 7563 50219800
Product use in unapproved indication 44.75 10.23 602 377159 115217 50112146
Neutrophil count decreased 44.71 10.23 184 377577 45842 50181521
Gestational diabetes 44.70 10.23 140 377621 7325 50220038
Hyperkalaemia 44.41 10.23 196 377565 47893 50179470
Delirium 44.15 10.23 142 377619 38050 50189313
Neck deformity 43.17 10.23 63 377698 1915 50225448
Product administration error 43.13 10.23 50 377711 19649 50207714
Hypothermia 42.80 10.23 18 377743 11998 50215365
Respiratory depression 42.76 10.23 18 377743 11992 50215371
Osteonecrosis of jaw 42.64 10.23 114 377647 32412 50194951
Shock 42.48 10.23 55 377706 20595 50206768
Disorientation 42.38 10.23 130 377631 35354 50192009
White blood cell count decreased 42.15 10.23 615 377146 116107 50111256
Infection 42.13 10.23 1634 376127 171320 50056043
Leukopenia 41.98 10.23 313 377448 67215 50160148
Maternal drugs affecting foetus 41.96 10.23 107 377654 4970 50222393
Speech disorder 41.91 10.23 131 377630 35417 50191946
Multiple fractures 41.46 10.23 126 377635 6485 50220878
Tuberculosis 41.37 10.23 167 377594 9916 50217447
Extrapyramidal disorder 41.33 10.23 18 377743 11752 50215611
Acute hepatic failure 41.01 10.23 34 377727 15643 50211720
Dyspnoea exertional 40.83 10.23 220 377541 51013 50176350
Hospitalisation 40.77 10.23 318 377443 67619 50159744
Creatinine renal clearance decreased 40.42 10.23 19 377742 11862 50215501
Rheumatoid nodule 40.17 10.23 195 377566 12540 50214823
Myocardial infarction 39.97 10.23 448 377313 88579 50138784
Suicidal ideation 39.76 10.23 246 377515 55139 50172224
Angioedema 39.55 10.23 146 377615 37530 50189833
Unresponsive to stimuli 38.83 10.23 109 377652 30500 50196863
Blood creatine phosphokinase increased 38.81 10.23 87 377674 26280 50201083
Abnormal behaviour 38.77 10.23 54 377707 19604 50207759
Posterior reversible encephalopathy syndrome 38.29 10.23 33 377728 14895 50212468
Memory impairment 37.77 10.23 394 377367 78966 50148397
Pre-eclampsia 37.72 10.23 139 377622 7905 50219458
Pain in jaw 37.72 10.23 153 377608 38275 50189088
Ascites 37.62 10.23 139 377622 35722 50191641
Deep vein thrombosis 37.36 10.23 358 377403 72946 50154417
Accidental overdose 37.20 10.23 55 377706 19478 50207885
Blood bilirubin increased 37.12 10.23 119 377642 31919 50195444
Drug level increased 36.94 10.23 54 377707 19214 50208149
Enthesopathy 36.90 10.23 128 377633 7065 50220298
Cerebral haemorrhage 36.85 10.23 93 377668 26959 50200404
Intentional product use issue 36.64 10.23 791 376970 76127 50151236
Blood alkaline phosphatase increased 36.46 10.23 150 377611 37376 50189987
Ventricular septal defect 36.39 10.23 88 377673 3953 50223410
Polyarthritis 36.36 10.23 136 377625 7791 50219572
Dysgeusia 36.30 10.23 158 377603 38758 50188605
Blood pressure decreased 36.27 10.23 256 377505 55653 50171710
Platelet count decreased 36.26 10.23 531 377230 100195 50127168
Metastases to liver 36.00 10.23 59 377702 20045 50207318
Bone pain 35.90 10.23 206 377555 47023 50180340
Joint stiffness 35.84 10.23 365 377396 29943 50197420
Blood pressure diastolic decreased 35.65 10.23 231 377530 16550 50210813
Nodule 35.47 10.23 233 377528 16770 50210593
Maternal exposure before pregnancy 35.41 10.23 107 377654 5490 50221873
Localised infection 35.13 10.23 317 377444 25168 50202195
Gamma-glutamyltransferase increased 35.04 10.23 109 377652 29514 50197849
Aspartate aminotransferase increased 34.81 10.23 393 377368 77605 50149758
Dysarthria 34.80 10.23 152 377609 37251 50190112
Brain oedema 34.68 10.23 25 377736 12345 50215018
Arrhythmia 34.38 10.23 129 377632 33003 50194360
Device dislocation 34.31 10.23 68 377693 21478 50205885
Blood calcium decreased 34.15 10.23 64 377697 20642 50206721
Palpitations 34.09 10.23 498 377263 94008 50133355
Oral herpes 33.98 10.23 268 377493 20457 50206906
Disseminated intravascular coagulation 33.86 10.23 47 377714 17088 50210275
Flushing 33.85 10.23 328 377433 66687 50160676
Injection site rash 33.34 10.23 221 377540 15956 50211407
Limb deformity 33.29 10.23 81 377680 3653 50223710
Dysphagia 33.27 10.23 394 377367 77124 50150239
Torsade de pointes 33.08 10.23 24 377737 11811 50215552
Premature delivery 32.95 10.23 295 377466 23368 50203995
Joint destruction 32.85 10.23 83 377678 3833 50223530
Vertigo 32.81 10.23 239 377522 51593 50175770
Injection site bruising 32.75 10.23 419 377342 36349 50191014
Inflammation 32.71 10.23 602 377159 56310 50171053
Chronic kidney disease 32.69 10.23 169 377592 39602 50187761
Tenderness 32.63 10.23 244 377517 18321 50209042
Anaphylactic shock 32.62 10.23 63 377698 20092 50207271
Pulmonary fibrosis 32.18 10.23 301 377460 24136 50203227
C-reactive protein increased 32.11 10.23 685 377076 65789 50161574
Haemorrhage 31.66 10.23 251 377510 53190 50174173
Disability 31.65 10.23 183 377578 12592 50214771
Akathisia 31.51 10.23 11 377750 8218 50219145
Diabetes mellitus inadequate control 31.41 10.23 31 377730 13114 50214249
Alanine aminotransferase increased 31.39 10.23 467 377294 87892 50139471
Premature rupture of membranes 31.30 10.23 90 377671 4490 50222873
Infective pulmonary exacerbation of cystic fibrosis 31.29 10.23 10 377751 7899 50219464
Small for dates baby 31.21 10.23 76 377685 3429 50223934
Nightmare 30.92 10.23 45 377716 16041 50211322
Musculoskeletal pain 30.86 10.23 731 377030 71446 50155917
Chest pain 30.82 10.23 1046 376715 175836 50051527
Neuroleptic malignant syndrome 30.55 10.23 23 377738 11107 50216256
Pleural effusion 30.51 10.23 426 377335 81028 50146335
Femur fracture 30.49 10.23 420 377341 37044 50190319
Inappropriate antidiuretic hormone secretion 30.27 10.23 32 377729 13111 50214252
Respiratory distress 30.17 10.23 121 377640 30368 50196995
Ventricular fibrillation 30.05 10.23 21 377740 10538 50216825
Tenosynovitis stenosans 29.92 10.23 57 377704 2167 50225196
Pulmonary oedema 29.86 10.23 228 377533 48710 50178653
Psychotic disorder 29.70 10.23 75 377686 21737 50205626
Ventricular tachycardia 29.69 10.23 45 377716 15776 50211587
Heart rate decreased 29.64 10.23 409 377352 36088 50191275
Blood pressure diastolic increased 29.53 10.23 122 377639 7321 50220042
Acute respiratory failure 29.26 10.23 113 377648 28669 50198694
Wrong technique in product usage process 29.18 10.23 269 377492 55241 50172122
Drug ineffective for unapproved indication 29.11 10.23 73 377688 21208 50206155
Hypomagnesaemia 28.98 10.23 83 377678 23073 50204290
International normalised ratio increased 28.77 10.23 196 377565 42956 50184407
Toxic skin eruption 28.70 10.23 25 377736 11226 50216137
Atrial fibrillation 28.61 10.23 561 377200 101184 50126179
Joint range of motion decreased 28.51 10.23 236 377525 18276 50209087
Withdrawal syndrome 28.45 10.23 55 377706 17535 50209828
Latent tuberculosis 28.36 10.23 56 377705 2187 50225176
Gastrointestinal haemorrhage 28.35 10.23 381 377380 72940 50154423
Smear cervix abnormal 28.31 10.23 63 377698 2678 50224685
Coagulopathy 28.26 10.23 57 377704 17887 50209476
Schizophrenia 28.13 10.23 10 377751 7387 50219976
Dyskinesia 27.93 10.23 110 377651 27751 50199612
Synovial cyst 27.92 10.23 128 377633 8038 50219325
Device difficult to use 27.69 10.23 20 377741 9866 50217497
Herpes zoster 27.59 10.23 708 377053 70078 50157285
Neurotoxicity 27.59 10.23 42 377719 14698 50212665
Cerebrovascular accident 27.55 10.23 519 377242 94161 50133202
Tenosynovitis 27.26 10.23 153 377608 10412 50216951
Eosinophilia 27.08 10.23 62 377699 18590 50208773
Melaena 26.97 10.23 106 377655 26758 50200605
Laryngitis 26.53 10.23 156 377605 10800 50216563
Polyneuropathy 26.33 10.23 31 377730 12100 50215263
Bronchospasm 26.22 10.23 44 377717 14810 50212553
Cytokine release syndrome 26.16 10.23 16 377745 8618 50218745
Irritability 26.15 10.23 116 377645 28310 50199053
Dysmorphism 26.08 10.23 53 377708 2114 50225249
Parkinsonism 25.98 10.23 17 377744 8830 50218533
Wheelchair user 25.96 10.23 89 377672 4883 50222480
Pulmonary hypertension 25.80 10.23 145 377616 33272 50194091
Mania 25.79 10.23 26 377735 10890 50216473
Bradyphrenia 25.76 10.23 7 377754 6145 50221218
Ischaemic stroke 25.68 10.23 50 377711 15898 50211465
Atrioventricular block complete 25.63 10.23 11 377750 7244 50220119
Sepsis 25.56 10.23 776 376985 132149 50095214
Jaundice 25.45 10.23 106 377655 26323 50201040
Metastases to central nervous system 25.39 10.23 28 377733 11254 50216109
Drug tolerance decreased 25.21 10.23 135 377626 9025 50218338
Arthritis infective 25.09 10.23 95 377666 5474 50221889
Asphyxia 25.05 10.23 5 377756 5422 50221941
Macular degeneration 25.05 10.23 43 377718 14345 50213018
Skin papilloma 25.04 10.23 79 377682 4150 50223213
Crying 24.95 10.23 74 377687 20342 50207021
Transplant rejection 24.94 10.23 21 377740 9588 50217775
Stress cardiomyopathy 24.77 10.23 14 377747 7873 50219490
Back pain 24.62 10.23 1367 376394 218663 50008700
Impaired quality of life 24.60 10.23 100 377661 5956 50221407
Blood creatinine increased 24.53 10.23 410 377351 75750 50151613
Malignant melanoma 24.53 10.23 144 377617 9964 50217399
Skin ulcer 24.44 10.23 385 377376 34933 50192430
Thrombotic microangiopathy 24.34 10.23 18 377743 8773 50218590
Aggression 24.06 10.23 79 377682 21037 50206326
Device use error 24.00 10.23 5 377756 5261 50222102
Fear 23.96 10.23 45 377716 14504 50212859
Pain in extremity 23.92 10.23 2356 375405 270509 49956854
Neck mass 23.90 10.23 67 377694 3294 50224069
Pancreatitis acute 23.88 10.23 94 377667 23718 50203645
Face oedema 23.78 10.23 62 377699 17777 50209586
Developmental hip dysplasia 23.77 10.23 38 377723 1253 50226110
Paralysis 23.66 10.23 18 377743 8646 50218717
Second primary malignancy 23.61 10.23 11 377750 6903 50220460
Obstructive airways disorder 23.57 10.23 51 377710 15601 50211762
Placental disorder 23.52 10.23 40 377721 1390 50225973
Pyrexia 23.52 10.23 2482 375279 377721 49849642
Oedema peripheral 23.51 10.23 952 376809 157009 50070354
Haematotoxicity 23.41 10.23 15 377746 7880 50219483
Hypomania 23.38 10.23 3 377758 4502 50222861
Oropharyngeal pain 23.37 10.23 753 377008 77048 50150315
Synovial fluid analysis 23.30 10.23 43 377718 1595 50225768
Febrile bone marrow aplasia 23.22 10.23 9 377752 6302 50221061
Acute myeloid leukaemia 22.79 10.23 49 377712 15025 50212338
Spinal stenosis 22.64 10.23 176 377585 13374 50213989
Acute generalised exanthematous pustulosis 22.63 10.23 20 377741 8918 50218445
Product adhesion issue 22.61 10.23 3 377758 4389 50222974
Polyhydramnios 22.58 10.23 48 377713 1977 50225386
Accidental exposure to product 22.50 10.23 92 377669 22965 50204398
Agranulocytosis 22.49 10.23 83 377678 21338 50206025
Abdominal distension 22.34 10.23 396 377365 72507 50154856
Graft versus host disease 22.34 10.23 9 377752 6157 50221206
Hypervolaemia 22.30 10.23 106 377655 25393 50201970
Confusional state 22.13 10.23 1148 376613 184780 50042583
Stomatitis 22.01 10.23 946 376815 100398 50126965
Rotator cuff repair 21.88 10.23 43 377718 1673 50225690
Unevaluable event 21.79 10.23 229 377532 45837 50181526
Immune reconstitution inflammatory syndrome 21.77 10.23 7 377754 5509 50221854
Pancreatitis 21.76 10.23 208 377553 42406 50184957
Body tinea 21.67 10.23 37 377724 1290 50226073
Miosis 21.61 10.23 10 377751 6300 50221063
Complication of device insertion 21.59 10.23 9 377752 6032 50221331
Loose body in joint 21.59 10.23 35 377726 1168 50226195
Depressed mood 21.47 10.23 157 377604 33866 50193497
Cardiac failure acute 21.45 10.23 18 377743 8232 50219131
Postoperative wound infection 21.39 10.23 122 377639 8353 50219010
Tardive dyskinesia 21.35 10.23 14 377747 7265 50220098
Therapeutic response decreased 21.31 10.23 482 377279 46749 50180614
Body temperature decreased 21.12 10.23 201 377560 16194 50211169
Pulmonary tuberculosis 21.02 10.23 75 377686 4198 50223165
Cardiogenic shock 20.95 10.23 54 377707 15545 50211818
Panic attack 20.93 10.23 74 377687 19268 50208095
Hemiparesis 20.84 10.23 78 377683 19970 50207393
Abdominal pain 20.83 10.23 1500 376261 234728 49992635
Substance abuse 20.80 10.23 3 377758 4121 50223242
Blood potassium decreased 20.75 10.23 176 377585 36769 50190594
Tachypnoea 20.73 10.23 49 377712 14528 50212835
Lethargy 20.54 10.23 253 377508 49179 50178184
Dystonia 20.44 10.23 36 377725 11890 50215473
Rash maculo-papular 20.35 10.23 116 377645 26525 50200838
Myoclonus 20.29 10.23 49 377712 14421 50212942
Dementia 20.27 10.23 57 377704 15940 50211423
Product dose omission issue 20.22 10.23 1144 376617 182694 50044669
Muscular weakness 20.20 10.23 547 377214 94466 50132897
Genital haemorrhage 20.18 10.23 12 377749 6562 50220801
Metastases to lung 20.05 10.23 32 377729 10988 50216375
Urinary retention 20.02 10.23 114 377647 26076 50201287
Anhedonia 19.97 10.23 25 377736 9499 50217864
Psychomotor hyperactivity 19.94 10.23 24 377737 9277 50218086
Atrial septal defect 19.93 10.23 97 377664 6244 50221119
Stevens-Johnson syndrome 19.87 10.23 89 377672 21663 50205700
Erythema multiforme 19.78 10.23 23 377738 9027 50218336
Gastroenteritis viral 19.76 10.23 221 377540 18565 50208798
Haemorrhage intracranial 19.75 10.23 39 377722 12335 50215028
Nervousness 19.75 10.23 123 377638 27528 50199835
COVID-19 19.70 10.23 238 377523 46424 50180939
Acute graft versus host disease 19.69 10.23 3 377758 3955 50223408
Tumour lysis syndrome 19.53 10.23 16 377745 7405 50219958
Cytopenia 19.50 10.23 22 377739 8753 50218610
Complication associated with device 19.48 10.23 51 377710 14604 50212759
Joint dislocation 19.41 10.23 158 377603 12175 50215188
Uterine perforation 19.28 10.23 12 377749 6403 50220960
Pemphigoid 19.26 10.23 10 377751 5897 50221466
Body height below normal 19.24 10.23 44 377717 1905 50225458
Sinus tachycardia 19.13 10.23 88 377673 21266 50206097
Glycosylated haemoglobin increased 19.11 10.23 31 377730 10575 50216788
Disease recurrence 19.05 10.23 81 377680 20000 50207363
Acute chest syndrome 19.02 10.23 24 377737 633 50226730
Foetal death 18.87 10.23 115 377646 8065 50219298
Injection site warmth 18.86 10.23 172 377589 13694 50213669
Joint injury 18.85 10.23 247 377514 21542 50205821
Plasma cell myeloma 18.60 10.23 147 377614 31175 50196188
Red blood cell sedimentation rate 18.56 10.23 64 377697 3522 50223841
Shock haemorrhagic 18.46 10.23 21 377740 8323 50219040
Foetal anticonvulsant syndrome 18.34 10.23 22 377739 550 50226813
Cushingoid 18.34 10.23 98 377663 6547 50220816
Atrioventricular block 18.28 10.23 13 377748 6465 50220898
Maternal exposure timing unspecified 18.21 10.23 64 377697 3556 50223807
Infusion site erythema 18.20 10.23 23 377738 8704 50218659
Congenital arterial malformation 18.00 10.23 17 377744 320 50227043
Headache 17.70 10.23 3423 374338 503112 49724251
Exposure to toxic agent 17.68 10.23 3 377758 3655 50223708
Joint noise 17.68 10.23 63 377698 3524 50223839
Device related infection 17.67 10.23 87 377674 20648 50206715
Cholecystitis chronic 17.67 10.23 28 377733 9641 50217722
Antinuclear antibody positive 17.65 10.23 93 377668 6179 50221184
Clear cell renal cell carcinoma 17.64 10.23 32 377729 1171 50226192
Labelled drug-drug interaction medication error 17.62 10.23 32 377729 10445 50216918
Paradoxical drug reaction 17.61 10.23 3 377758 3644 50223719
Salivary hypersecretion 17.61 10.23 14 377747 6577 50220786
Myocarditis 17.58 10.23 20 377741 7927 50219436
Status epilepticus 17.56 10.23 47 377714 13359 50214004
Crohn's disease 17.55 10.23 76 377685 4657 50222706
Fear of injection 17.52 10.23 91 377670 6012 50221351
Acidosis 17.41 10.23 31 377730 10196 50217167
Hypertransaminasaemia 17.37 10.23 3 377758 3608 50223755
Haemorrhage in pregnancy 17.34 10.23 39 377722 1670 50225693
Haematoma 17.29 10.23 145 377616 30365 50196998
Synovial disorder 17.28 10.23 27 377734 873 50226490
Dactylitis 17.27 10.23 41 377720 1820 50225543
Stillbirth 17.26 10.23 89 377672 5863 50221500
Subdural haematoma 17.25 10.23 45 377716 12902 50214461
Dry skin 17.22 10.23 223 377538 42968 50184395
Infusion site pain 17.16 10.23 42 377719 12304 50215059
Ketoacidosis 17.14 10.23 4 377757 3891 50223472
Gestational hypertension 17.14 10.23 45 377716 2128 50225235
Breast feeding 17.06 10.23 26 377735 822 50226541
Scleritis 17.05 10.23 58 377703 3169 50224194
Hepatotoxicity 17.01 10.23 126 377635 27100 50200263
Hallucination, auditory 16.96 10.23 34 377727 10694 50216669
Complication of device removal 16.95 10.23 5 377756 4159 50223204
Multiple allergies 16.94 10.23 23 377738 8440 50218923
Leukocytosis 16.88 10.23 99 377662 22480 50204883
Lupus-like syndrome 16.82 10.23 125 377636 9366 50217997
Skin cancer 16.81 10.23 124 377637 9270 50218093
Off label use 16.77 10.23 3204 374557 471222 49756141
Haemophagocytic lymphohistiocytosis 16.74 10.23 24 377737 8609 50218754
Haemoptysis 16.63 10.23 117 377644 25456 50201907
Cardiomyopathy 16.62 10.23 60 377701 15526 50211837
Tubulointerstitial nephritis 16.59 10.23 58 377703 15153 50212210
Wheezing 16.57 10.23 345 377416 61702 50165661
Clostridium difficile colitis 16.56 10.23 72 377689 17670 50209693
Mood altered 16.56 10.23 45 377716 12728 50214635
Fracture 16.36 10.23 195 377566 16638 50210725
Skin exfoliation 16.34 10.23 166 377595 33446 50193917
Aphasia 16.34 10.23 135 377626 28359 50199004
Proteinuria 16.33 10.23 66 377695 16531 50210832
Talipes 16.33 10.23 34 377727 1380 50225983
Diabetes mellitus 16.11 10.23 263 377498 48770 50178593
Oedema 15.98 10.23 400 377361 69781 50157582
Dislocation of vertebra 15.89 10.23 55 377706 3032 50224331
Fracture delayed union 15.82 10.23 45 377716 2231 50225132
Bone marrow failure 15.78 10.23 131 377630 27493 50199870
Hyperprolactinaemia 15.75 10.23 3 377758 3362 50224001
Hypophosphataemia 15.72 10.23 24 377737 8390 50218973
Catheter site erythema 15.69 10.23 5 377756 3957 50223406
Hallucination, visual 15.66 10.23 67 377694 16515 50210848
Hypophagia 15.61 10.23 132 377629 27596 50199767
Mouth ulceration 15.60 10.23 295 377466 27729 50199634
Temperature regulation disorder 15.60 10.23 6 377755 4221 50223142
Incorrect route of product administration 15.51 10.23 79 377682 18587 50208776
Angina pectoris 15.51 10.23 123 377638 26065 50201298
Cerebral infarction 15.48 10.23 96 377665 21508 50205855
Muscle twitching 15.42 10.23 61 377700 15370 50211993
Pulmonary congestion 15.41 10.23 60 377701 15187 50212176
Immunodeficiency 15.40 10.23 174 377587 14654 50212709
Cellulitis 15.40 10.23 661 377100 70137 50157226
Bone density decreased 15.38 10.23 138 377623 10937 50216426
Lymphocyte count decreased 15.38 10.23 124 377637 26183 50201180
Pathogen resistance 15.30 10.23 12 377749 5677 50221686
Malaise 15.28 10.23 2234 375527 333298 49894065
Aspergillus infection 15.27 10.23 17 377744 6804 50220559
Neonatal respiratory distress syndrome 15.19 10.23 49 377712 2605 50224758
Affective disorder 15.15 10.23 10 377751 5171 50222192
Injection site haematoma 15.14 10.23 87 377674 5973 50221390
Human antichimeric antibody positive 15.13 10.23 34 377727 1455 50225908
Impaired work ability 15.06 10.23 162 377599 13478 50213885
Infection susceptibility increased 15.05 10.23 48 377713 2536 50224827
Pharyngitis streptococcal 15.05 10.23 115 377646 8693 50218670
Poor venous access 14.96 10.23 130 377631 10210 50217153
Vascular device infection 14.93 10.23 7 377754 4377 50222986
Infusion site swelling 14.88 10.23 19 377742 7157 50220206
Colitis microscopic 14.87 10.23 16 377745 6504 50220859
Bronchopulmonary aspergillosis 14.83 10.23 21 377740 7571 50219792
Gastrointestinal disorder 14.75 10.23 854 376907 93602 50133761
Respiration abnormal 14.71 10.23 10 377751 5092 50222271
Toxic epidermal necrolysis 14.67 10.23 94 377667 20898 50206465
Delusion 14.65 10.23 36 377725 10533 50216830
Polyuria 14.61 10.23 19 377742 7102 50220261
Cyanosis 14.56 10.23 61 377700 15123 50212240
Generalised oedema 14.55 10.23 53 377708 13678 50213685
Bundle branch block left 14.53 10.23 15 377746 6215 50221148
Right ventricular failure 14.53 10.23 65 377696 15828 50211535
Catheter site pain 14.46 10.23 5 377756 3757 50223606
Antibody test positive 14.45 10.23 44 377717 2267 50225096
Myopathy 14.42 10.23 29 377732 9110 50218253
Squamous cell carcinoma 14.33 10.23 103 377658 7636 50219727
Pericardial effusion 14.33 10.23 122 377639 25467 50201896
Speech disorder developmental 14.28 10.23 20 377741 585 50226778
Lip swelling 14.27 10.23 117 377644 24619 50202744
Rash erythematous 14.24 10.23 179 377582 34673 50192690
Sleep apnoea syndrome 14.18 10.23 112 377649 23756 50203607
Dysuria 14.18 10.23 140 377621 28364 50198999
Exomphalos 14.13 10.23 19 377742 534 50226829
Aspiration 14.10 10.23 30 377731 9234 50218129
Blood glucose decreased 14.07 10.23 79 377682 18132 50209231
Cholestasis of pregnancy 14.01 10.23 28 377733 1103 50226260
Pseudomonas infection 13.97 10.23 31 377730 9399 50217964
Bone disorder 13.97 10.23 207 377554 18545 50208818
Coronary artery disease 13.97 10.23 148 377613 29578 50197785
Oliguria 13.90 10.23 25 377736 8191 50219172
Tendonitis 13.89 10.23 188 377573 16517 50210846
Renal injury 13.86 10.23 27 377734 8584 50218779
Surgery 13.86 10.23 309 377452 29896 50197467
Immunosuppression 13.85 10.23 99 377662 7327 50220036
Device breakage 13.65 10.23 32 377729 9515 50217848
Ankylosing spondylitis 13.64 10.23 96 377665 7069 50220294
Blood iron increased 13.64 10.23 31 377730 1337 50226026
Product prescribing error 13.58 10.23 96 377665 20865 50206498
Anuria 13.56 10.23 41 377720 11203 50216160
Joint lock 13.56 10.23 40 377721 2025 50225338
Influenza 13.50 10.23 807 376954 88731 50138632
Abdominal pain upper 13.48 10.23 1015 376746 158294 50069069
Hepatic cytolysis 13.40 10.23 25 377736 8078 50219285
Autism spectrum disorder 13.37 10.23 21 377740 682 50226681
Hypertelorism 13.31 10.23 16 377745 401 50226962
Hallucinations, mixed 13.30 10.23 7 377754 4096 50223267
Foetal distress syndrome 13.30 10.23 29 377732 1216 50226147
Tumour marker increased 13.28 10.23 6 377755 3834 50223529
Muscle rigidity 13.22 10.23 34 377727 9795 50217568
Colitis 13.21 10.23 205 377556 38324 50189039
Anger 13.19 10.23 42 377719 11291 50216072
Visual acuity reduced 13.16 10.23 92 377669 20047 50207316
Mental disorder 13.16 10.23 103 377658 21888 50205475
Myelosuppression 13.15 10.23 54 377707 13463 50213900
Personality disorder 13.12 10.23 8 377753 4316 50223047
Induced labour 13.01 10.23 24 377737 890 50226473
Klebsiella infection 12.99 10.23 21 377740 7173 50220190
Cervical incompetence 12.89 10.23 19 377742 583 50226780
Therapy change 12.86 10.23 12 377749 5213 50222150
Hereditary angioedema 12.81 10.23 13 377748 5429 50221934
Foot fracture 12.78 10.23 216 377545 19875 50207488
Visual impairment 12.77 10.23 400 377361 67875 50159488
Occult blood 12.76 10.23 28 377733 1179 50226184
Product substitution issue 12.55 10.23 58 377703 13999 50213364
Swollen tongue 12.48 10.23 145 377616 28485 50198878
Acute myocardial infarction 12.47 10.23 149 377612 29124 50198239
Transplant dysfunction 12.45 10.23 10 377751 4674 50222689
Dermatitis exfoliative 12.43 10.23 12 377749 5130 50222233
Ulcer 12.42 10.23 216 377545 19984 50207379
Acute pulmonary oedema 12.39 10.23 22 377739 7245 50220118
Tendon disorder 12.39 10.23 75 377686 5247 50222116
Joint warmth 12.38 10.23 30 377731 1349 50226014
Tongue disorder 12.38 10.23 114 377647 9102 50218261
Wound infection 12.37 10.23 142 377619 12006 50215357
Malignant mediastinal neoplasm 12.36 10.23 18 377743 546 50226817
Lymphatic fistula 12.36 10.23 21 377740 729 50226634
Infusion site pruritus 12.35 10.23 7 377754 3930 50223433
Pulseless electrical activity 12.32 10.23 20 377741 6821 50220542
Product complaint 12.32 10.23 44 377717 11422 50215941
Pneumonia viral 12.29 10.23 20 377741 6814 50220549
Arthritis bacterial 12.27 10.23 78 377683 5551 50221812
Polydipsia 12.27 10.23 4 377757 3120 50224243
Drug abuser 12.26 10.23 3 377758 2825 50224538
Multiple sclerosis 12.25 10.23 96 377665 20397 50206966
Urinary incontinence 12.24 10.23 143 377618 28065 50199298
Trigeminal neuralgia 12.21 10.23 4 377757 3111 50224252
Bone density abnormal 12.15 10.23 50 377711 2995 50224368
Femoral hernia incarcerated 12.14 10.23 21 377740 740 50226623
Epstein-Barr virus infection 12.10 10.23 21 377740 6976 50220387
Toxic encephalopathy 12.07 10.23 14 377747 5501 50221862
Human anti-human antibody test 12.05 10.23 15 377746 390 50226973
Drug-induced liver injury 11.97 10.23 143 377618 27952 50199411
Hot flush 11.97 10.23 245 377516 43924 50183439
Systemic inflammatory response syndrome 11.96 10.23 12 377749 5037 50222326
Lymphoedema 11.93 10.23 32 377729 9090 50218273
Serum ferritin increased 11.91 10.23 73 377688 5129 50222234
Injection site irritation 11.90 10.23 64 377697 4286 50223077
Treatment noncompliance 11.89 10.23 156 377605 29994 50197369
Maternal exposure during breast feeding 11.87 10.23 52 377709 3202 50224161
Blood loss anaemia 11.86 10.23 27 377734 8112 50219251
Eating disorder 11.82 10.23 67 377694 15342 50212021
Wound infection pseudomonas 11.76 10.23 28 377733 1245 50226118
Pregnancy with contraceptive device 11.76 10.23 8 377753 4071 50223292
Multiple-drug resistance 11.74 10.23 5 377756 3309 50224054
Patent ductus arteriosus 11.70 10.23 58 377703 3762 50223601
Endodontic procedure 11.68 10.23 46 377715 2700 50224663
Pulmonary haemorrhage 11.67 10.23 19 377742 6473 50220890
Potentiating drug interaction 11.66 10.23 7 377754 3809 50223554
Amylase increased 11.65 10.23 14 377747 5416 50221947
Abortion missed 11.63 10.23 32 377729 1556 50225807
Hyperthyroidism 11.62 10.23 49 377712 12126 50215237
Sexual dysfunction 11.61 10.23 5 377756 3287 50224076
Respiratory acidosis 11.45 10.23 17 377744 6011 50221352
Bone lesion 11.45 10.23 13 377748 5157 50222206
Abnormal dreams 11.45 10.23 34 377727 9343 50218020
Affect lability 11.44 10.23 32 377729 8966 50218397
Abortion threatened 11.43 10.23 17 377744 526 50226837
Ear infection 11.39 10.23 264 377497 25706 50201657
Circulatory collapse 11.36 10.23 95 377666 19905 50207458
Cardiotoxicity 11.34 10.23 22 377739 7005 50220358
Renal disorder 11.34 10.23 141 377620 27364 50199999
Pancytopenia 11.31 10.23 750 377011 83280 50144083
Ingrown hair 11.30 10.23 16 377745 473 50226890
Anterior chamber cleavage syndrome 11.23 10.23 10 377751 174 50227189
Catatonia 11.21 10.23 7 377754 3729 50223634
Peripheral sensory neuropathy 11.20 10.23 20 377741 6571 50220792
Presyncope 11.16 10.23 121 377640 24077 50203286
Learning disorder 11.12 10.23 18 377743 600 50226763
Crystal nephropathy 11.10 10.23 21 377740 794 50226569
Rheumatoid lung 11.06 10.23 42 377719 2423 50224940
Food allergy 11.06 10.23 28 377733 8109 50219254
Bronchitis 11.03 10.23 912 376849 103247 50124116
Coronary arterial stent insertion 11.02 10.23 3 377758 2631 50224732
Bradykinesia 11.01 10.23 8 377753 3935 50223428
Body temperature increased 11 10.23 166 377595 31175 50196188
Intervertebral disc degeneration 10.99 10.23 151 377610 13310 50214053
Troponin increased 10.98 10.23 28 377733 8090 50219273
Renal tubular necrosis 10.94 10.23 39 377722 10129 50217234
Paranoia 10.92 10.23 40 377721 10308 50217055
Knee operation 10.92 10.23 68 377693 4805 50222558
Cyst 10.90 10.23 139 377622 12048 50215315
Cardiac disorder 10.89 10.23 241 377520 42738 50184625
Carpal tunnel syndrome 10.88 10.23 182 377579 16711 50210652
Sinus bradycardia 10.84 10.23 56 377705 13127 50214236
Inhibitory drug interaction 10.82 10.23 39 377722 2194 50225169
Forceps delivery 10.82 10.23 10 377751 183 50227180
Eosinophil count increased 10.79 10.23 32 377729 8798 50218565
Lung adenocarcinoma 10.75 10.23 60 377701 4074 50223289
Drug screen positive 10.74 10.23 6 377755 3396 50223967
Acute coronary syndrome 10.73 10.23 35 377726 9339 50218024
Injection site haemorrhage 10.64 10.23 221 377540 21125 50206238
Abortion incomplete 10.63 10.23 5 377756 3121 50224242
Myofascial pain syndrome 10.63 10.23 37 377724 2046 50225317
Alanine aminotransferase abnormal 10.60 10.23 60 377701 4096 50223267
Placental insufficiency 10.59 10.23 27 377734 1254 50226109
Chills 10.55 10.23 602 377159 96085 50131278
Inadequate analgesia 10.54 10.23 3 377758 2555 50224808
Embedded device 10.51 10.23 4 377757 2833 50224530
Stress at work 10.47 10.23 24 377737 1041 50226322
Chondropathy 10.45 10.23 37 377724 2063 50225300
Nail injury 10.45 10.23 15 377746 449 50226914
Inflammatory marker increased 10.44 10.23 75 377686 5559 50221804
Lung transplant 10.44 10.23 4 377757 2821 50224542
Lymphadenectomy 10.42 10.23 22 377739 902 50226461
Device issue 10.40 10.23 97 377664 19875 50207488
Rhinitis allergic 10.40 10.23 24 377737 7176 50220187
Threatened labour 10.38 10.23 20 377741 767 50226596
Incorrect product administration duration 10.36 10.23 35 377726 9240 50218123
Hepatitis acute 10.36 10.23 28 377733 7933 50219430
Ankyloglossia congenital 10.34 10.23 10 377751 194 50227169
Paraesthesia 10.34 10.23 765 376996 119478 50107885
Breast cancer metastatic 10.33 10.23 41 377720 10323 50217040
Pancreatic steatosis 10.33 10.23 22 377739 907 50226456
Head injury 10.33 10.23 122 377639 23898 50203465
Ileus paralytic 10.33 10.23 9 377752 4041 50223322
Vacuum extractor delivery 10.32 10.23 9 377752 152 50227211
Adverse event 10.29 10.23 412 377349 43351 50184012
Pleuritic pain 10.26 10.23 83 377678 6383 50220980
Somnambulism 10.25 10.23 13 377748 4911 50222452
Congenital hydronephrosis 10.24 10.23 14 377747 400 50226963

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Rheumatoid arthritis 524.60 9.83 691 135012 31461 29407363
Foetal exposure during pregnancy 301.13 9.83 550 135153 33317 29405507
Drug abuse 300.89 9.83 16 135687 79867 29358957
Toxicity to various agents 223.94 9.83 281 135422 173380 29265444
Arthralgia 212.30 9.83 1227 134476 138390 29300434
Completed suicide 202.98 9.83 80 135623 90166 29348658
Psoriatic arthropathy 154.48 9.83 257 135446 14434 29424390
Dysmorphism 131.27 9.83 109 135594 2862 29435962
Drug interaction 120.34 9.83 482 135221 196903 29241921
Joint swelling 108.87 9.83 484 135219 49146 29389678
Sickle cell anaemia with crisis 107.64 9.83 92 135611 2516 29436308
Premature baby 102.98 9.83 238 135465 17042 29421782
Psoriasis 88.60 9.83 337 135366 31890 29406934
Enthesopathy 88.13 9.83 97 135606 3646 29435178
Exposure during pregnancy 85.09 9.83 146 135557 8408 29430416
Intentional overdose 83.57 9.83 36 135667 38492 29400332
Speech disorder developmental 78.15 9.83 67 135636 1840 29436984
Acute kidney injury 73.48 9.83 821 134882 264446 29174378
Neonatal respiratory distress syndrome 73.34 9.83 89 135614 3721 29435103
Tenosynovitis 73.17 9.83 88 135615 3645 29435179
Blood pressure fluctuation 71.14 9.83 227 135476 19667 29419157
Musculoskeletal stiffness 68.77 9.83 347 135356 37111 29401713
Atrial septal defect 66.38 9.83 115 135588 6674 29432150
Hypospadias 65.89 9.83 75 135628 2927 29435897
Foetal anticonvulsant syndrome 64.95 9.83 49 135654 1115 29437709
Nasopharyngitis 62.88 9.83 479 135224 59186 29379638
Death 60.99 9.83 1155 134548 340929 29097895
Pain 59.96 9.83 1112 134591 170320 29268504
Overdose 59.95 9.83 178 135525 79641 29359183
Drug reaction with eosinophilia and systemic symptoms 59.37 9.83 27 135676 27965 29410859
Maternal drugs affecting foetus 57.82 9.83 80 135623 3813 29435011
Synovitis 57.36 9.83 143 135560 10747 29428077
Autism spectrum disorder 57.35 9.83 58 135645 1974 29436850
Maternal exposure during pregnancy 57.19 9.83 82 135621 4041 29434783
Low birth weight baby 55.76 9.83 105 135598 6503 29432321
Small for dates baby 52.34 9.83 73 135630 3506 29435318
Suicide attempt 51.82 9.83 48 135655 34062 29404762
C-reactive protein abnormal 51.65 9.83 101 135602 6435 29432389
Learning disorder 50.44 9.83 40 135663 982 29437842
Cryptorchism 50.42 9.83 53 135650 1889 29436935
Hypoglycaemia neonatal 50.11 9.83 50 135653 1674 29437150
Serotonin syndrome 47.50 9.83 11 135692 17501 29421323
Arthritis 47.49 9.83 234 135469 24785 29414039
Coma 47.47 9.83 67 135636 39383 29399441
Tongue disorder 45.94 9.83 79 135624 4557 29434267
Ventricular septal defect 45.78 9.83 68 135635 3461 29435363
Hepatic function abnormal 44.97 9.83 69 135634 39190 29399634
Maternal exposure during breast feeding 44.86 9.83 44 135659 1442 29437382
Product use in unapproved indication 44.48 9.83 226 135477 86649 29352175
Rhabdomyolysis 43.94 9.83 138 135565 60670 29378154
Drug resistance 43.81 9.83 22 135681 21518 29417306
Palmar-plantar erythrodysaesthesia syndrome 42.65 9.83 8 135695 14751 29424073
Foot deformity 41.88 9.83 70 135633 3945 29434879
Febrile neutropenia 41.46 9.83 323 135380 111917 29326907
Basal cell carcinoma 40.96 9.83 170 135533 16740 29422084
Arthropathy 39.78 9.83 200 135503 21354 29417470
Syndactyly 39.68 9.83 31 135672 744 29438080
Drug intolerance 39.07 9.83 366 135337 48013 29390811
Pulmonary fibrosis 38.81 9.83 158 135545 15424 29423400
Rheumatoid nodule 38.32 9.83 48 135655 2074 29436750
Haemoglobin decreased 37.82 9.83 703 135000 107672 29331152
Developmental delay 37.78 9.83 52 135651 2466 29436358
Osteoarthritis 37.76 9.83 174 135529 17929 29420895
Lower respiratory tract infection 37.59 9.83 229 135474 26273 29412551
Blood pressure systolic increased 36.69 9.83 164 135539 16681 29422143
Exposure via breast milk 36.27 9.83 42 135661 1670 29437154
Drug dependence 36.25 9.83 26 135677 20955 29417869
Intentional product misuse 35.91 9.83 65 135638 34596 29404228
Joint laxity 34.68 9.83 22 135681 374 29438450
Pancytopenia 34.23 9.83 554 135149 82614 29356210
Congenital hand malformation 33.63 9.83 25 135678 556 29438268
Infusion related reaction 33.45 9.83 328 135375 43558 29395266
Bradycardia 33.43 9.83 171 135532 65458 29373366
Tendonitis 33.30 9.83 96 135607 7865 29430959
Talipes 33.10 9.83 41 135662 1751 29437073
Angioedema 32.93 9.83 60 135643 31855 29406969
Alanine aminotransferase abnormal 32.79 9.83 53 135650 2904 29435920
Jaundice neonatal 32.11 9.83 34 135669 1222 29437602
Respiratory arrest 31.95 9.83 43 135660 25790 29413034
Renal failure 31.95 9.83 369 135334 118230 29320594
Blood pressure increased 31.64 9.83 495 135208 73308 29365516
Hypermobility syndrome 31.63 9.83 20 135683 338 29438486
Blood pressure systolic abnormal 31.48 9.83 44 135659 2117 29436707
Intellectual disability 31.26 9.83 32 135671 1105 29437719
Foetal growth restriction 30.74 9.83 59 135644 3707 29435117
Language disorder 30.21 9.83 41 135662 1918 29436906
Pain in extremity 30.18 9.83 691 135012 109742 29329082
Joint effusion 29.89 9.83 62 135641 4122 29434702
Hyperglycaemia 29.07 9.83 72 135631 34215 29404609
Drug withdrawal syndrome 28.89 9.83 24 135679 17960 29420864
Delirium 28.74 9.83 89 135614 39308 29399516
Large for dates baby 28.16 9.83 27 135676 860 29437964
Cardiac failure 27.95 9.83 231 135472 79056 29359768
Plagiocephaly 27.72 9.83 21 135682 481 29438343
Polyarthritis 27.65 9.83 58 135645 3887 29434937
Peripheral swelling 27.12 9.83 427 135276 63312 29375512
Suicidal ideation 27.08 9.83 76 135627 34640 29404184
Serum ferritin increased 26.96 9.83 71 135632 5517 29433307
Loss of personal independence in daily activities 26.64 9.83 204 135499 25236 29413588
Hyperbilirubinaemia neonatal 26.28 9.83 24 135679 718 29438106
Astigmatism 25.99 9.83 27 135676 949 29437875
Sedation 25.84 9.83 25 135678 17380 29421444
Somnolence 25.81 9.83 291 135412 93664 29345160
Knee deformity 25.65 9.83 21 135682 540 29438284
Cytomegalovirus infection 25.45 9.83 42 135661 23173 29415651
Skin cancer 25.31 9.83 91 135612 8377 29430447
Off label use 25.24 9.83 1126 134577 299674 29139150
Knee arthroplasty 25.22 9.83 71 135632 5738 29433086
Constipation 24.93 9.83 371 135332 113789 29325035
Musculoskeletal pain 24.87 9.83 222 135481 28731 29410093
Caesarean section 24.87 9.83 37 135666 1886 29436938
Hand deformity 24.75 9.83 39 135664 2091 29436733
Motor developmental delay 24.66 9.83 22 135681 638 29438186
Dysgraphia 24.63 9.83 38 135665 2000 29436824
Hypoglycaemia 24.60 9.83 126 135577 48220 29390604
Lactic acidosis 24.50 9.83 65 135638 30182 29408642
Selective eating disorder 24.44 9.83 34 135669 1629 29437195
Psychotic disorder 24.06 9.83 35 135668 20319 29418505
Multiple organ dysfunction syndrome 24.05 9.83 180 135523 62936 29375888
Behaviour disorder 24.00 9.83 52 135651 3564 29435260
Disease progression 23.98 9.83 250 135453 81666 29357158
Drug withdrawal syndrome neonatal 23.89 9.83 50 135653 3345 29435479
Agitation 23.74 9.83 138 135565 51166 29387658
Altered state of consciousness 23.70 9.83 34 135669 19855 29418969
Depressed level of consciousness 23.19 9.83 89 135614 36853 29401971
Otitis media 22.92 9.83 42 135661 2547 29436277
Strabismus 22.39 9.83 30 135673 1386 29437438
Hypotonia neonatal 22.33 9.83 28 135675 1211 29437613
Blood pressure diastolic decreased 22.31 9.83 77 135626 6945 29431879
Poisoning 22.20 9.83 9 135694 9984 29428840
Pathogen resistance 22.20 9.83 5 135698 8111 29430713
Blood pressure diastolic abnormal 22.10 9.83 41 135662 2510 29436314
Cardiac arrest 22.00 9.83 269 135434 85322 29353502
Body temperature decreased 21.87 9.83 102 135601 10562 29428262
Hydrocele 21.65 9.83 35 135668 1918 29436906
Medical device implantation 21.15 9.83 19 135684 556 29438268
Substance abuse 21.13 9.83 3 135700 6784 29432040
Attention deficit hyperactivity disorder 20.95 9.83 37 135666 2180 29436644
C-reactive protein increased 20.95 9.83 302 135401 43961 29394863
Agitation neonatal 20.87 9.83 25 135678 1031 29437793
Dyslexia 20.83 9.83 15 135688 317 29438507
Crohn's disease 20.81 9.83 44 135659 2965 29435859
Urticaria 20.77 9.83 156 135547 54504 29384320
Blood creatine phosphokinase increased 20.63 9.83 106 135597 40538 29398286
Vitamin D deficiency 20.60 9.83 64 135639 5465 29433359
Shock 20.55 9.83 42 135661 21362 29417462
Dyspraxia 20.45 9.83 16 135687 385 29438439
Arthritis bacterial 20.21 9.83 55 135648 4358 29434466
Anal fistula 19.93 9.83 53 135650 4142 29434682
Heart rate decreased 19.87 9.83 188 135515 24724 29414100
Juvenile idiopathic arthritis 19.74 9.83 28 135675 1366 29437458
Foetal disorder 19.67 9.83 21 135682 762 29438062
Renal impairment 19.64 9.83 259 135444 81074 29357750
Patent ductus arteriosus 19.62 9.83 44 135659 3087 29435737
Wound 19.55 9.83 108 135595 11955 29426869
Congenital anomaly 19.29 9.83 27 135676 1301 29437523
Colitis ulcerative 19.17 9.83 112 135591 12657 29426167
Acute hepatic failure 19.14 9.83 16 135687 11936 29426888
Post procedural infection 19.07 9.83 53 135650 4252 29434572
Lacrimal disorder 18.92 9.83 14 135689 309 29438515
Neuroleptic malignant syndrome 18.86 9.83 28 135675 16120 29422704
Psychomotor retardation 18.85 9.83 42 135661 2934 29435890
Cleft lip 18.81 9.83 14 135689 312 29438512
Renal aplasia 18.78 9.83 19 135684 647 29438177
Tuberculosis 18.74 9.83 74 135629 7122 29431702
Bronchiolitis 18.72 9.83 40 135663 2715 29436109
Congenital bladder anomaly 18.67 9.83 13 135690 260 29438564
Limb reduction defect 18.63 9.83 13 135690 261 29438563
Weight decrease neonatal 18.54 9.83 14 135689 319 29438505
Intentional self-injury 18.38 9.83 18 135685 12443 29426381
Rash maculo-papular 18.33 9.83 54 135649 24235 29414589
Congenital foot malformation 18.32 9.83 15 135688 386 29438438
Malignant melanoma 18.14 9.83 73 135630 7088 29431736
Injection site pain 18.08 9.83 228 135475 32218 29406606
Blood pressure diastolic increased 17.95 9.83 47 135656 3639 29435185
Haematocrit decreased 17.94 9.83 208 135495 28814 29410010
Back disorder 17.69 9.83 64 135639 5909 29432915
Ankyloglossia congenital 17.68 9.83 13 135690 284 29438540
Scoliosis 17.52 9.83 35 135668 2265 29436559
Nasal disorder 17.49 9.83 27 135676 1422 29437402
Haemangioma congenital 17.40 9.83 16 135687 483 29438341
Diaphragmatic disorder 17.39 9.83 22 135681 960 29437864
Electrocardiogram QT prolonged 17.37 9.83 96 135607 36041 29402783
Joint range of motion decreased 17.20 9.83 64 135639 5990 29432834
Proteinuria 16.95 9.83 29 135674 15775 29423049
Microcephaly 16.91 9.83 19 135684 731 29438093
Joint stiffness 16.84 9.83 87 135616 9386 29429438
Diabetic ketoacidosis 16.77 9.83 30 135673 16043 29422781
Infective pulmonary exacerbation of cystic fibrosis 16.75 9.83 4 135699 6232 29432592
Multiple congenital abnormalities 16.73 9.83 16 135687 508 29438316
Hepatic failure 16.67 9.83 81 135622 31431 29407393
Lung neoplasm malignant 16.67 9.83 118 135585 14239 29424585
Arthrodesis 16.58 9.83 15 135688 443 29438381
Umbilical hernia 16.56 9.83 46 135657 3689 29435135
Bradycardia neonatal 16.55 9.83 21 135682 919 29437905
Respiratory disorder neonatal 16.43 9.83 26 135677 1399 29437425
Inflammation 16.41 9.83 168 135535 22560 29416264
Polydactyly 16.29 9.83 23 135680 1117 29437707
Grip strength decreased 16.26 9.83 34 135669 2273 29436551
Vitamin B12 deficiency 16.23 9.83 42 135661 3229 29435595
Weight decreased 16.18 9.83 847 134856 150058 29288766
Pectus excavatum 16.15 9.83 11 135692 212 29438612
C-reactive protein decreased 16.12 9.83 27 135676 1524 29437300
Septic arthritis staphylococcal 15.90 9.83 15 135688 468 29438356
Spinal disorder 15.88 9.83 45 135658 3650 29435174
Hallucination 15.87 9.83 130 135573 44582 29394242
Hypertelorism 15.86 9.83 16 135687 543 29438281
Red blood cell sedimentation rate increased 15.77 9.83 72 135631 7389 29431435
Pyrexia 15.76 9.83 1122 134581 286500 29152324
Ear disorder 15.74 9.83 24 135679 1250 29437574
Neck mass 15.68 9.83 26 135677 1455 29437369
Haemangioma 15.66 9.83 28 135675 1666 29437158
Respiratory rate increased 15.50 9.83 80 135623 8628 29430196
Neurotoxicity 15.50 9.83 27 135676 14586 29424238
Cellulitis 15.49 9.83 296 135407 45544 29393280
Oesophageal fibrosis 15.46 9.83 10 135693 176 29438648
Status epilepticus 15.45 9.83 16 135687 10778 29428046
Immunodeficiency 15.27 9.83 50 135653 4390 29434434
Ankylosing spondylitis 15.24 9.83 48 135655 4128 29434696
Therapeutic product effect decreased 15.17 9.83 204 135499 29247 29409577
Poor venous access 15.08 9.83 40 135663 3121 29435703
Infection 15.08 9.83 460 135243 76291 29362533
Maternal exposure timing unspecified 15.04 9.83 13 135690 361 29438463
Arnold-Chiari malformation 14.68 9.83 12 135691 308 29438516
Contraindicated product administered 14.64 9.83 138 135565 18128 29420696
Prostate cancer 14.49 9.83 180 135523 25347 29413477
Inguinal hernia 14.48 9.83 65 135638 6623 29432201
Hernia pain 14.41 9.83 11 135692 255 29438569
Oropharyngeal pain 14.33 9.83 201 135502 29084 29409740
Emphysema 14.30 9.83 78 135625 8593 29430231
Venoocclusive liver disease 14.16 9.83 7 135696 6910 29431914
Ear infection 14.13 9.83 74 135629 8026 29430798
Pneumonia 14.09 9.83 1676 134027 318496 29120328
Foetal distress syndrome 14.05 9.83 20 135683 979 29437845
Foetal heart rate deceleration abnormality 13.88 9.83 14 135689 475 29438349
Blood parathyroid hormone decreased 13.87 9.83 18 135685 806 29438018
Vascular insufficiency 13.86 9.83 12 135691 334 29438490
Arthritis infective 13.75 9.83 36 135667 2788 29436036
Injection site bruising 13.75 9.83 70 135633 7510 29431314
Anal atresia 13.63 9.83 11 135692 277 29438547
Unresponsive to stimuli 13.63 9.83 64 135639 25062 29413762
Spina bifida 13.62 9.83 12 135691 342 29438482
Pleural fibrosis 13.56 9.83 23 135680 1312 29437512
Tooth malformation 13.51 9.83 9 135694 167 29438657
Peripheral artery thrombosis 13.50 9.83 30 135673 2092 29436732
Blood insulin increased 13.48 9.83 12 135691 347 29438477
Diverticular perforation 13.48 9.83 37 135666 2947 29435877
Radiation inflammation 13.47 9.83 10 135693 222 29438602
Finger deformity 13.42 9.83 21 135682 1119 29437705
Incorrect route of product administration 13.33 9.83 18 135685 10783 29428041
Cerebral haemorrhage 13.25 9.83 87 135616 31339 29407485
Respiratory failure 13.16 9.83 342 135361 96789 29342035
Mouth ulceration 13.15 9.83 87 135616 10268 29428556
Oxygen saturation decreased 13.14 9.83 284 135419 44653 29394171
Developmental coordination disorder 13.10 9.83 9 135694 176 29438648
Ear malformation 12.95 9.83 11 135692 298 29438526
Stevens-Johnson syndrome 12.95 9.83 36 135667 16461 29422363
Congenital hydronephrosis 12.85 9.83 16 135687 687 29438137
Hyperammonaemia 12.75 9.83 5 135698 5658 29433166
Palindromic rheumatism 12.67 9.83 9 135694 186 29438638
Haemolysis 12.45 9.83 64 135639 6892 29431932
Red blood cell sedimentation rate 12.43 9.83 14 135689 540 29438284
Gangrene neonatal 12.43 9.83 9 135694 192 29438632
No adverse event 12.38 9.83 40 135663 17438 29421386
Lipase increased 12.35 9.83 12 135691 8325 29430499
Aggression 12.31 9.83 104 135599 35437 29403387
Product quality issue 12.24 9.83 35 135668 15860 29422964
Maternal exposure before pregnancy 12.19 9.83 13 135690 471 29438353
Neonatal seizure 12.19 9.83 13 135690 471 29438353
Excessive cerumen production 12.19 9.83 10 135693 258 29438566
Pulmonary artery stenosis congenital 12.15 9.83 13 135690 473 29438351
Anaphylactic shock 12.11 9.83 27 135676 13309 29425515
Kidney infection 12.07 9.83 48 135655 4635 29434189
Neck pain 12.07 9.83 151 135552 21296 29417528
Neonatal infection 12.04 9.83 12 135691 401 29438423
Second primary malignancy 11.99 9.83 8 135695 6697 29432127
Meningeal disorder 11.96 9.83 11 135692 332 29438492
Lung cancer metastatic 11.88 9.83 31 135672 2396 29436428
Cleft palate 11.83 9.83 14 135689 570 29438254
Wrong technique in product usage process 11.79 9.83 90 135613 31338 29407486
Aspergillus infection 11.73 9.83 19 135684 10562 29428262
Sexual dysfunction 11.73 9.83 6 135697 5808 29433016
Irritability 11.68 9.83 57 135646 22095 29416729
Hepatic enzyme increased 11.68 9.83 219 135484 33580 29405244
Sinusitis 11.67 9.83 222 135481 34128 29404696
Non-Hodgkin's lymphoma 11.67 9.83 23 135680 1474 29437350
Nephrolithiasis 11.65 9.83 172 135531 25162 29413662
Osteonecrosis of jaw 11.54 9.83 38 135665 16472 29422352
Low set ears 11.48 9.83 12 135691 425 29438399
Steatorrhoea 11.43 9.83 15 135688 679 29438145
Localised infection 11.38 9.83 105 135598 13711 29425113
Mean cell volume increased 11.38 9.83 31 135672 2458 29436366
Abnormal behaviour 11.35 9.83 61 135642 23066 29415758
Progressive multifocal leukoencephalopathy 11.31 9.83 14 135689 8705 29430119
Educational problem 11.28 9.83 13 135690 514 29438310
Cholelithiasis 11.17 9.83 133 135570 18539 29420285
Drug ineffective for unapproved indication 11.17 9.83 31 135672 14183 29424641
Synovial cyst 11.16 9.83 26 135677 1871 29436953
Fine motor skill dysfunction 11.10 9.83 23 135680 1528 29437296
Foetal hypokinesia 11.05 9.83 11 135692 367 29438457
Hypoxia 11.02 9.83 152 135551 47227 29391597
Hepatocellular injury 11.01 9.83 55 135648 21188 29417636
Back pain 10.93 9.83 574 135129 101710 29337114
Agranulocytosis 10.92 9.83 52 135651 20288 29418536
Tachycardia 10.89 9.83 251 135452 72159 29366665
Pharyngeal disorder 10.85 9.83 14 135689 623 29438201
Malignant neoplasm progression 10.83 9.83 257 135446 73602 29365222
Lung neoplasm 10.80 9.83 44 135659 4296 29434528
Hypertriglyceridaemia 10.79 9.83 11 135692 7464 29431360
Disseminated intravascular coagulation 10.78 9.83 51 135652 19929 29418895
Dermatitis psoriasiform 10.76 9.83 19 135684 1119 29437705
Decreased appetite 10.76 9.83 551 135152 144791 29294033
Tonsil cancer 10.75 9.83 17 135686 914 29437910
Pancreatic duct stenosis 10.72 9.83 8 135695 179 29438645
Oesophageal atresia 10.69 9.83 12 135691 461 29438363
Granuloma skin 10.67 9.83 14 135689 634 29438190
Vomiting 10.65 9.83 834 134869 211426 29227398
Peritoneal dialysis complication 10.64 9.83 23 135680 1574 29437250
Acute chest syndrome 10.63 9.83 10 135693 311 29438513
Joint instability 10.56 9.83 11 135692 388 29438436
Skin lesion 10.55 9.83 131 135572 18441 29420383
Neutropenia neonatal 10.51 9.83 14 135689 643 29438181
Moaning 10.51 9.83 15 135688 736 29438088
Dysgeusia 10.48 9.83 61 135642 22613 29416211
Heart rate irregular 10.46 9.83 99 135604 13018 29425806
Nose deformity 10.46 9.83 8 135695 186 29438638
Glycosylated haemoglobin increased 10.38 9.83 17 135686 9409 29429415
Obsessive-compulsive disorder 10.37 9.83 4 135699 4572 29434252
Anti-erythropoietin antibody positive 10.34 9.83 16 135687 844 29437980
Pharyngitis 10.32 9.83 61 135642 6922 29431902
Transfusion-related circulatory overload 10.28 9.83 8 135695 191 29438633
Respiratory depression 10.25 9.83 30 135673 13493 29425331
Mesothelioma 10.24 9.83 11 135692 402 29438422
Retinopathy hypertensive 10.23 9.83 9 135694 256 29438568
Withdrawal syndrome 10.19 9.83 22 135681 10970 29427854
Skin graft failure 10.18 9.83 7 135696 137 29438687
Chronic obstructive pulmonary disease 10.17 9.83 253 135450 40702 29398122
Pulmonary tuberculosis 10.15 9.83 43 135660 4272 29434552
Injection site swelling 10.13 9.83 76 135627 9341 29429483
Necrotising fasciitis streptococcal 10.10 9.83 7 135696 139 29438685
Psychomotor skills impaired 10.10 9.83 31 135672 2630 29436194
Brain oedema 10.09 9.83 26 135677 12194 29426630
Congenital diaphragmatic hernia 10.09 9.83 9 135694 261 29438563
Chronic graft versus host disease 10.03 9.83 3 135700 4026 29434798
Cytokine release syndrome 10.02 9.83 29 135674 13090 29425734
Suspected suicide 10.00 9.83 3 135700 4017 29434807
Placental insufficiency 10.00 9.83 6 135697 92 29438732
Gross motor delay 9.97 9.83 9 135694 265 29438559
Mucosal ulceration 9.96 9.83 16 135687 872 29437952
Hypermetropia 9.96 9.83 11 135692 415 29438409
Hypocalcaemia 9.87 9.83 55 135648 20610 29418214
Cholestasis 9.87 9.83 65 135638 23397 29415427

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Rheumatoid arthritis 1286.33 9.86 2948 381285 161346 63953153
Completed suicide 878.34 9.86 142 384091 224272 63890227
Pemphigus 824.46 9.86 1375 382858 59326 64055173
Arthropathy 815.11 9.86 2049 382184 118918 63995581
Systemic lupus erythematosus 798.63 9.86 1558 382675 76054 64038445
Joint swelling 795.23 9.86 2953 381280 212429 63902070
Hand deformity 763.41 9.86 1354 382879 61417 64053082
Synovitis 741.67 9.86 1748 382485 97342 64017157
Toxicity to various agents 726.68 9.86 658 383575 362855 63751644
Glossodynia 695.28 9.86 1323 382910 63373 64051126
Arthralgia 677.12 9.86 4728 379505 437532 63676967
Maternal exposure during pregnancy 641.39 9.86 1620 382613 94264 64020235
Drug abuse 615.44 9.86 45 384188 132329 63982170
Infusion related reaction 615.03 9.86 2265 381968 162202 63952297
Anti-cyclic citrullinated peptide antibody positive 574.34 9.86 1047 383186 48515 64065984
Wound 562.24 9.86 1340 382893 75137 64039362
Pericarditis 540.30 9.86 1168 383065 61348 64053151
Pain 497.93 9.86 5258 378975 548253 63566246
Abdominal discomfort 463.50 9.86 2232 382001 180090 63934409
Alopecia 430.23 9.86 2041 382192 163649 63950850
Swelling 401.79 9.86 1954 382279 158264 63956235
Therapeutic product effect decreased 400.59 9.86 1552 382681 113799 64000700
Contraindicated product administered 399.39 9.86 1481 382752 106348 64008151
Drug interaction 399.37 9.86 988 383245 361095 63753404
Nasopharyngitis 399.29 9.86 2257 381976 193816 63920683
Discomfort 384.86 9.86 1208 383025 79670 64034829
Death 349.82 9.86 1583 382650 481122 63633377
Rheumatoid factor positive 343.01 9.86 688 383545 34250 64080249
Drug intolerance 338.89 9.86 2096 382137 185896 63928603
Duodenal ulcer perforation 331.79 9.86 675 383558 33950 64080549
Helicobacter infection 330.52 9.86 716 383517 37646 64076853
Exposure during pregnancy 328.89 9.86 1115 383118 76560 64037939
Musculoskeletal stiffness 309.74 9.86 1504 382729 121702 63992797
Intentional overdose 300.16 9.86 82 384151 89862 64024637
Hepatic enzyme increased 296.21 9.86 1543 382690 128400 63986099
Acute kidney injury 272.11 9.86 1567 382666 447673 63666826
Psoriatic arthropathy 249.27 9.86 692 383541 42589 64071910
C-reactive protein abnormal 242.09 9.86 535 383698 28512 64085987
Febrile neutropenia 230.95 9.86 482 383751 187175 63927324
Sinusitis 228.61 9.86 1571 382662 144357 63970142
Impaired healing 220.78 9.86 827 383406 59646 64054853
Overdose 220.74 9.86 382 383851 159184 63955315
Lower respiratory tract infection 202.22 9.86 1104 383129 93510 64020989
Product use issue 198.06 9.86 1564 382669 150151 63964348
Peripheral swelling 196.52 9.86 2007 382226 207146 63907353
Red blood cell sedimentation rate abnormal 195.85 9.86 350 383883 15956 64098543
Cardiac arrest 194.38 9.86 390 383843 153674 63960825
Hypersensitivity 192.21 9.86 1901 382332 194551 63919948
Treatment failure 191.53 9.86 1272 382961 115544 63998955
Blood pressure fluctuation 180.79 9.86 699 383534 51172 64063327
Muscle injury 180.05 9.86 450 383783 25987 64088512
Drug ineffective 176.46 9.86 6382 377851 833865 63280634
Depressed level of consciousness 176.33 9.86 136 384097 81300 64033199
Arthritis 172.43 9.86 968 383265 82846 64031653
Sickle cell anaemia with crisis 171.01 9.86 184 384049 5148 64109351
Suicide attempt 167.69 9.86 108 384125 70899 64043600
Folliculitis 165.44 9.86 473 383760 29604 64084895
Weight increased 161.47 9.86 1962 382271 211386 63903113
Bradycardia 159.86 9.86 287 383946 117932 63996567
Sleep disorder due to general medical condition, insomnia type 159.20 9.86 428 383805 25842 64088657
Hip arthroplasty 158.82 9.86 376 383857 20975 64093524
Knee arthroplasty 156.75 9.86 433 383800 26566 64087933
Irritable bowel syndrome 155.97 9.86 534 383699 36835 64077664
Respiratory arrest 144.88 9.86 67 384166 52918 64061581
Drug reaction with eosinophilia and systemic symptoms 144.51 9.86 71 384162 54146 64060353
Psoriasis 144.09 9.86 823 383410 70880 64043619
Pregnancy 142.97 9.86 356 383877 20509 64093990
Rhabdomyolysis 137.68 9.86 208 384025 91518 64022981
Osteoarthritis 136.61 9.86 741 383492 62595 64051904
Cardiac failure 134.32 9.86 376 383857 131997 63982502
Blister 132.27 9.86 881 383352 80086 64034413
Renal failure 132.26 9.86 594 383639 181094 63933405
Abortion spontaneous 130.21 9.86 387 383846 24756 64089743
Lactic acidosis 129.86 9.86 105 384128 61305 64053194
Injection site erythema 123.98 9.86 784 383449 70016 64044483
Sedation 123.74 9.86 46 384187 41416 64073083
Contusion 120.83 9.86 1122 383111 112843 64001656
Hepatic function abnormal 120.46 9.86 123 384110 64190 64050309
Infection 119.95 9.86 1653 382580 183227 63931272
Sopor 119.93 9.86 17 384216 29644 64084855
Malignant neoplasm progression 113.47 9.86 322 383911 112549 64001950
Disease progression 112.47 9.86 448 383785 141232 63973267
Ill-defined disorder 108.60 9.86 535 383698 43517 64070982
Red blood cell sedimentation rate increased 107.26 9.86 419 383814 30816 64083683
Enthesopathy 107.04 9.86 200 384033 9438 64105061
Serotonin syndrome 105.35 9.86 51 384182 39231 64075268
Blood pressure systolic increased 102.90 9.86 573 383660 48880 64065619
Fatigue 102.54 9.86 5444 378789 743286 63371213
Neutropenia 102.36 9.86 923 383310 238701 63875798
Constipation 101.65 9.86 875 383358 228462 63886037
Injection site pruritus 100.19 9.86 469 383764 37357 64077142
Injection site pain 99.73 9.86 1059 383174 110349 64004150
Hypoglycaemia 99.04 9.86 245 383988 89647 64024852
Drug resistance 98.14 9.86 43 384190 35059 64079440
Respiratory failure 96.84 9.86 563 383670 160620 63953879
Agitation 96.45 9.86 242 383991 88125 64026374
Multiple organ dysfunction syndrome 94.96 9.86 299 383934 101114 64013385
Hyponatraemia 94.63 9.86 508 383725 147831 63966668
Joint effusion 94.55 9.86 232 384001 13241 64101258
Hypotension 93.70 9.86 1651 382582 379323 63735176
Drug dependence 92.82 9.86 41 384192 33271 64081228
Condition aggravated 92.18 9.86 2886 381347 369540 63744959
Juvenile idiopathic arthritis 91.07 9.86 114 384119 3765 64110734
Blood pressure diastolic abnormal 90.95 9.86 212 384021 11705 64102794
Hyperglycaemia 89.80 9.86 140 384093 60828 64053671
Hepatic failure 89.68 9.86 119 384114 55275 64059224
Live birth 89.57 9.86 203 384030 11001 64103498
Cytomegalovirus infection 88.61 9.86 56 384177 37143 64077356
Blood pressure systolic abnormal 87.25 9.86 187 384046 9755 64104744
Intentional product misuse 86.92 9.86 188 384045 72107 64042392
Coma 86.55 9.86 252 383981 87363 64027136
Renal impairment 86.33 9.86 462 383771 134555 63979944
Osteoporosis 85.84 9.86 485 383748 41595 64072904
Cardio-respiratory arrest 85.32 9.86 300 383933 98093 64016406
Rheumatic fever 85.26 9.86 178 384055 9116 64105383
Injection site reaction 84.34 9.86 521 383712 46143 64068356
Rash 84.29 9.86 3435 380798 455114 63659385
Pain in extremity 84.26 9.86 2383 381850 300702 63813797
Rheumatoid nodule 83.69 9.86 213 384020 12438 64102061
Product use in unapproved indication 83.16 9.86 663 383570 175955 63938544
Disability assessment scale score increased 82.36 9.86 88 384145 2442 64112057
Injection site swelling 81.32 9.86 472 383761 40881 64073618
Somnolence 81.12 9.86 798 383435 202847 63911652
Fibromyalgia 79.72 9.86 422 383811 35309 64079190
Tenosynovitis 79.08 9.86 200 384033 11633 64102866
Caesarean section 78.97 9.86 194 384039 11080 64103419
Electrocardiogram QT prolonged 78.85 9.86 228 384005 79220 64035279
Swollen joint count increased 78.55 9.86 154 384079 7535 64106964
Grip strength decreased 78.19 9.86 198 384035 11526 64102973
Musculoskeletal pain 77.60 9.86 783 383450 80511 64033988
Intentional self-injury 77.44 9.86 38 384195 29006 64085493
Blood pressure diastolic decreased 77.25 9.86 300 383933 22001 64092498
Palmar-plantar erythrodysaesthesia syndrome 74.90 9.86 39 384194 28780 64085719
Hypoxia 72.97 9.86 274 383959 87875 64026624
Poisoning 72.87 9.86 20 384213 21859 64092640
Foot deformity 72.53 9.86 240 383993 16264 64098235
Device expulsion 71.00 9.86 19 384214 21117 64093382
Blood pressure increased 70.22 9.86 1430 382803 171122 63943377
Heart rate decreased 69.75 9.86 564 383669 54503 64059996
Joint laxity 69.25 9.86 77 384156 2237 64112262
Altered state of consciousness 68.16 9.86 75 384158 37827 64076672
Disseminated intravascular coagulation 67.52 9.86 56 384177 32292 64082207
Tachycardia 67.44 9.86 568 383665 149011 63965488
Neoplasm progression 67.33 9.86 87 384146 40877 64073622
Joint stiffness 67.09 9.86 358 383875 30046 64084453
Delirium 66.90 9.86 201 384032 68993 64045506
Localised infection 66.46 9.86 355 383878 29806 64084693
Gastrointestinal disorder 66.45 9.86 822 383411 88887 64025612
C-reactive protein increased 66.20 9.86 860 383373 94049 64020450
Drug withdrawal syndrome 65.53 9.86 54 384179 31237 64083262
Shock 65.17 9.86 79 384154 38161 64076338
Encephalopathy 65.02 9.86 160 384073 58659 64055840
Inflammation 64.76 9.86 634 383599 64666 64049833
Respiratory depression 63.53 9.86 30 384203 23413 64091086
Loss of personal independence in daily activities 62.62 9.86 684 383549 71770 64042729
Injection site bruising 62.55 9.86 401 383832 35972 64078527
Thrombocytopenia 62.49 9.86 947 383286 222854 63891645
Bone erosion 61.49 9.86 180 384053 11415 64103084
Basal cell carcinoma 61.30 9.86 353 383880 30485 64084014
Polyarthritis 60.59 9.86 160 384073 9555 64104944
Oral herpes 60.38 9.86 277 383956 21875 64092624
Gestational diabetes 59.60 9.86 114 384119 5476 64109023
Herpes zoster 59.25 9.86 727 383506 78460 64036039
Metabolic acidosis 59.09 9.86 220 384013 70738 64043761
Cholestasis 58.79 9.86 111 384122 44761 64069738
Cardiac failure congestive 58.34 9.86 497 383736 130083 63984416
Blood creatine phosphokinase increased 58.14 9.86 168 384065 58390 64056109
Syncope 58.12 9.86 629 383604 157006 63957493
Angioedema 57.34 9.86 183 384050 61638 64052861
Blood pressure diastolic increased 57.10 9.86 167 384066 10585 64103914
Tongue disorder 57.00 9.86 180 384053 11900 64102599
Neuropathy peripheral 56.77 9.86 438 383795 117087 63997412
Femur fracture 56.67 9.86 373 383860 33762 64080737
Oropharyngeal pain 56.52 9.86 792 383441 88075 64026424
Immune reconstitution inflammatory syndrome 55.80 9.86 5 384228 12465 64102034
Stomatitis 55.58 9.86 940 383293 108665 64005834
Anaemia 55.40 9.86 1776 382457 376904 63737595
Cerebral haemorrhage 54.90 9.86 141 384092 50949 64063550
Mydriasis 54.89 9.86 12 384221 15300 64099199
Diabetic ketoacidosis 54.84 9.86 58 384175 29787 64084712
Tremor 54.43 9.86 592 383641 147638 63966861
Hepatocellular injury 54.06 9.86 118 384115 45117 64069382
Cognitive disorder 53.99 9.86 159 384074 54928 64059571
Acute hepatic failure 53.53 9.86 46 384187 26066 64088433
Premature delivery 52.58 9.86 235 383998 18354 64096145
Hyperhidrosis 52.05 9.86 484 383749 124436 63990063
Body temperature decreased 51.67 9.86 297 383936 25631 64088868
Tendonitis 51.18 9.86 248 383985 20034 64094465
Neuroleptic malignant syndrome 50.07 9.86 45 384188 24951 64089548
Hypothermia 49.95 9.86 28 384205 19828 64094671
Nodule 49.35 9.86 225 384008 17722 64096777
Injection site rash 49.12 9.86 205 384028 15537 64098962
Vomiting 48.57 9.86 2737 381496 548380 63566119
Disturbance in attention 48.38 9.86 108 384125 40966 64073533
Hallucination 48.22 9.86 246 383987 72542 64041957
Pulmonary fibrosis 48.10 9.86 324 383909 29554 64084945
Pre-eclampsia 47.72 9.86 111 384122 6120 64108379
Hyperkalaemia 47.40 9.86 380 383853 100749 64013750
Sedation complication 46.74 9.86 4 384229 10350 64104149
Fracture 46.37 9.86 228 384005 18527 64095972
Joint destruction 46.19 9.86 80 384153 3556 64110943
Synovial cyst 46.12 9.86 125 384108 7582 64106917
Maternal exposure before pregnancy 46.04 9.86 78 384155 3405 64111094
Abnormal behaviour 45.98 9.86 81 384152 33541 64080958
Tenderness 45.44 9.86 234 383999 19368 64095131
Brain oedema 45.11 9.86 39 384194 22036 64092463
Neck deformity 44.55 9.86 53 384180 1659 64112840
Mental status changes 44.43 9.86 200 384033 60962 64053537
Asthenia 44.31 9.86 2091 382142 425953 63688546
Myalgia 43.97 9.86 672 383561 157945 63956554
Hypokalaemia 43.89 9.86 489 383744 121414 63993085
Restlessness 43.36 9.86 109 384124 39676 64074823
Joint injury 43.23 9.86 259 383974 22688 64091811
Disability 43.19 9.86 165 384068 12007 64102492
Myocardial infarction 42.80 9.86 712 383521 165109 63949390
Red blood cell sedimentation rate 42.41 9.86 78 384155 3636 64110863
Joint range of motion decreased 42.16 9.86 227 384006 19116 64095383
Ventricular tachycardia 42.10 9.86 88 384145 34177 64080322
Dyspnoea 41.97 9.86 3699 380534 714975 63399524
Alanine aminotransferase abnormal 41.50 9.86 112 384121 6776 64107723
Unresponsive to stimuli 41.46 9.86 157 384076 50236 64064263
Leukopenia 41.43 9.86 394 383839 100848 64013651
Respiratory distress 41.16 9.86 166 384067 52165 64062334
Premature labour 41.09 9.86 119 384114 7501 64106998
Orthostatic hypotension 40.84 9.86 142 384091 46596 64067903
Infective pulmonary exacerbation of cystic fibrosis 40.78 9.86 10 384223 11786 64102713
Premature rupture of membranes 40.71 9.86 77 384156 3667 64110832
Anxiety 40.71 9.86 908 383325 201741 63912758
Laryngitis 40.35 9.86 151 384082 10880 64103619
Neurotoxicity 40.28 9.86 63 384170 27341 64087158
Limb deformity 40.17 9.86 72 384161 3289 64111210
Venoocclusive liver disease 39.88 9.86 6 384227 10009 64104490
Irritability 39.80 9.86 101 384132 36645 64077854
Poor venous access 39.76 9.86 163 384070 12254 64102245
Seizure 39.74 9.86 727 383506 166165 63948334
Disorientation 39.69 9.86 184 384049 55644 64058855
Dizziness 39.38 9.86 2128 382105 428035 63686464
Skin ulcer 39.32 9.86 418 383815 43556 64070943
Speech disorder 39.16 9.86 152 384081 48289 64066210
Blood glucose increased 39.14 9.86 384 383849 97689 64016810
Decreased appetite 39.02 9.86 1328 382905 279961 63834538
Neck mass 38.92 9.86 79 384154 3965 64110534
Anaphylactic shock 38.87 9.86 76 384157 30252 64084247
Posterior reversible encephalopathy syndrome 38.47 9.86 48 384185 22898 64091601
Diarrhoea 38.43 9.86 3746 380487 718958 63395541
Substance abuse 38.34 9.86 5 384228 9287 64105212
Influenza 38.20 9.86 867 383366 105664 64008835
Arthritis infective 38.11 9.86 110 384123 6920 64107579
Neutrophil count decreased 38.07 9.86 286 383947 76910 64037589
Bronchitis 38.06 9.86 882 383351 107861 64006638
Smear cervix abnormal 38.00 9.86 58 384175 2316 64112183
Tuberculosis 37.76 9.86 166 384067 12872 64101627
Dehydration 37.32 9.86 994 383239 215769 63898730
Extrapyramidal disorder 37.05 9.86 37 384196 19515 64094984
Latent tuberculosis 36.79 9.86 62 384171 2695 64111804
Aggression 36.77 9.86 146 384087 46086 64068413
Psychotic disorder 36.71 9.86 96 384137 34482 64080017
Myoclonus 36.68 9.86 58 384175 25060 64089439
Pulmonary arterial hypertension 36.64 9.86 59 384174 25308 64089191
Melaena 36.60 9.86 179 384054 53369 64061130
Cytokine release syndrome 36.59 9.86 42 384191 20787 64093712
Pulmonary embolism 36.28 9.86 633 383600 145723 63968776
Urticaria 36.25 9.86 638 383595 146679 63967820
Bone disorder 36.07 9.86 196 384037 16563 64097936
Multiple sclerosis relapse 35.93 9.86 125 384108 41010 64073489
Ejection fraction decreased 35.88 9.86 73 384160 28634 64085865
Accidental overdose 35.75 9.86 93 384140 33464 64081035
Pathogen resistance 35.64 9.86 15 384218 12528 64101971
Spinal stenosis 35.62 9.86 171 384062 13760 64100739
Psychomotor hyperactivity 35.47 9.86 21 384212 14430 64100069
Cardiogenic shock 35.22 9.86 89 384144 32338 64082161
Multiple fractures 35.18 9.86 97 384136 5943 64108556
Therapeutic response decreased 35.17 9.86 470 383763 51718 64062781
Ventricular fibrillation 34.93 9.86 55 384178 23805 64090694
Fluid retention 34.81 9.86 210 384023 59396 64055103
Drug level increased 34.75 9.86 97 384136 34099 64080400
Second primary malignancy 34.66 9.86 15 384218 12322 64102177
Aspergillus infection 34.62 9.86 28 384205 16351 64098148
Rash maculo-papular 34.62 9.86 153 384080 46873 64067626
Fear of injection 34.49 9.86 95 384138 5817 64108682
Arrhythmia 34.46 9.86 180 384053 52764 64061735
Immunodeficiency 34.31 9.86 188 384045 15936 64098563
Gastrointestinal haemorrhage 34.17 9.86 568 383665 131744 63982755
Suicidal ideation 34.03 9.86 244 383989 66298 64048201
Inappropriate antidiuretic hormone secretion 33.96 9.86 50 384183 22239 64092260
Torsade de pointes 33.90 9.86 32 384201 17331 64097168
Blood cholesterol increased 33.78 9.86 451 383782 49615 64064884
Ear infection 33.69 9.86 247 383986 23157 64091342
Cerebral infarction 33.68 9.86 128 384105 40916 64073583
Mouth ulceration 33.64 9.86 318 383915 32126 64082373
Status epilepticus 33.59 9.86 48 384185 21615 64092884
Skin cancer 33.58 9.86 151 384082 11823 64102676
Agranulocytosis 33.50 9.86 116 384117 38113 64076386
Atrial fibrillation 33.39 9.86 770 383463 170319 63944180
Wheelchair user 33.37 9.86 81 384152 4591 64109908
Asphyxia 33.28 9.86 8 384225 9558 64104941
Blood creatinine increased 33.10 9.86 589 383644 135193 63979306
Tenosynovitis stenosans 32.96 9.86 49 384184 1911 64112588
Ascites 32.86 9.86 225 384008 61776 64052723
Proteinuria 32.57 9.86 73 384160 27650 64086849
Bradyphrenia 32.47 9.86 8 384225 9398 64105101
Nausea 32.21 9.86 4146 380087 781654 63332845
Ischaemic stroke 32.07 9.86 79 384154 28956 64085543
Surgery 32.03 9.86 282 383951 27931 64086568
Pancytopenia 31.85 9.86 1097 383136 142212 63972287
Skin papilloma 31.75 9.86 85 384148 5118 64109381
Intentional product use issue 31.70 9.86 768 383465 94596 64019903
Haematotoxicity 31.28 9.86 19 384214 12877 64101622
Bronchopulmonary aspergillosis 30.88 9.86 41 384192 19044 64095455
Akathisia 30.78 9.86 15 384218 11495 64103004
Product administration error 30.70 9.86 75 384158 27568 64086931
Transplant rejection 30.67 9.86 35 384198 17366 64097133
Coagulopathy 30.65 9.86 93 384140 31827 64082672
Gastroenteritis viral 30.60 9.86 212 384021 19517 64094982
Foot fracture 30.50 9.86 199 384034 17958 64096541
Tachypnoea 30.38 9.86 71 384162 26500 64087999
Malignant melanoma 30.22 9.86 155 384078 12809 64101690
Miosis 30.20 9.86 21 384212 13245 64101254
Balance disorder 30.07 9.86 337 383896 83589 64030910
Joint noise 30.04 9.86 62 384171 3149 64111350
Injection site warmth 30.03 9.86 159 384074 13303 64101196
Withdrawal syndrome 30.00 9.86 59 384174 23433 64091066
Product quality issue 29.93 9.86 85 384148 29714 64084785
Emotional distress 29.82 9.86 112 384121 35926 64078573
Mobility decreased 29.35 9.86 694 383539 85146 64029353
Shock haemorrhagic 29.34 9.86 34 384199 16757 64097742
Unintentional medical device removal 29.34 9.86 3 384230 6731 64107768
Asthma 28.98 9.86 396 383837 94829 64019670
Acute graft versus host disease 28.97 9.86 9 384224 9075 64105424
Synovial fluid analysis 28.97 9.86 41 384192 1528 64112971
Rotator cuff repair 28.91 9.86 40 384193 1459 64113040
Coronary artery disease 28.81 9.86 226 384007 60207 64054292
Acute respiratory failure 28.60 9.86 177 384056 49757 64064742
Eosinophilia 28.57 9.86 123 384110 37953 64076546
Vision blurred 28.42 9.86 373 383860 89943 64024556
No adverse event 28.30 9.86 82 384151 28479 64086020
Drug ineffective for unapproved indication 28.28 9.86 93 384140 31040 64083459
Rhinorrhoea 28.12 9.86 508 383725 59461 64055038
Blood parathyroid hormone decreased 27.92 9.86 102 384131 7264 64107235
Ulcer 27.78 9.86 233 384000 22757 64091742
Pulmonary oedema 27.76 9.86 317 383916 78357 64036142
Foetal death 27.65 9.86 88 384145 5842 64108657
Forced expiratory volume decreased 27.61 9.86 4 384229 6863 64107636
Haemoptysis 27.50 9.86 175 384058 48873 64065626
Subdural haematoma 27.47 9.86 81 384152 27973 64086526
Maternal exposure timing unspecified 27.39 9.86 54 384179 2653 64111846
Loose body in joint 27.33 9.86 35 384198 1183 64113316
Gamma-glutamyltransferase increased 27.24 9.86 173 384060 48337 64066162
Fear 27.22 9.86 49 384184 20122 64094377
Haemorrhage intracranial 27.16 9.86 64 384169 23820 64090679
Hypertransaminasaemia 27.10 9.86 5 384228 7186 64107313
Dysarthria 27.01 9.86 225 384008 59181 64055318
Loss of consciousness 26.94 9.86 675 383558 147690 63966809
Thrombotic microangiopathy 26.73 9.86 36 384197 16619 64097880
Sepsis 26.69 9.86 1111 383122 229230 63885269
Acute chest syndrome 26.59 9.86 30 384203 886 64113613
Blood alkaline phosphatase increased 26.58 9.86 211 384022 56068 64058431
Graft versus host disease 26.34 9.86 26 384207 13787 64100712
BK virus infection 26.18 9.86 6 384227 7406 64107093
Blood bilirubin increased 26.16 9.86 218 384015 57335 64057164
Osteonecrosis of jaw 26.14 9.86 135 384098 39690 64074809
Anaphylactic reaction 26.09 9.86 272 383961 68392 64046107
Toxic skin eruption 25.88 9.86 47 384186 19237 64095262
Clostridium difficile colitis 25.65 9.86 80 384153 27143 64087356
Hyperthermia 25.58 9.86 33 384200 15517 64098982
Tumour lysis syndrome 25.54 9.86 48 384185 19392 64095107
Creatinine renal clearance decreased 25.42 9.86 29 384204 14392 64100107
Post procedural infection 25.41 9.86 119 384114 9478 64105021
Mania 25.33 9.86 36 384197 16250 64098249
Respiratory disorder 25.09 9.86 120 384113 35991 64078508
Cellulitis 25.01 9.86 733 383500 92924 64021575
Acute respiratory distress syndrome 24.99 9.86 133 384100 38802 64075697
Oxygen saturation decreased 24.97 9.86 825 383408 106351 64008148
Antinuclear antibody positive 24.93 9.86 88 384145 6162 64108337
Dysgeusia 24.80 9.86 171 384062 46876 64067623
Polyhydramnios 24.75 9.86 37 384196 1450 64113049
Leukocytosis 24.74 9.86 128 384105 37612 64076887
Muscle spasms 24.70 9.86 645 383588 140378 63974121
Impaired work ability 24.47 9.86 165 384068 15054 64099445
Dystonia 24.42 9.86 47 384186 18818 64095681
Postoperative wound infection 24.38 9.86 124 384109 10212 64104287
Fracture delayed union 24.34 9.86 43 384190 1942 64112557
Glycosylated haemoglobin increased 24.34 9.86 36 384197 15983 64098516
Chronic kidney disease 24.29 9.86 224 384009 57695 64056804
Acidosis 24.21 9.86 43 384190 17752 64096747
Deep vein thrombosis 24.15 9.86 461 383772 104721 64009778
Erythema multiforme 24.13 9.86 35 384198 15666 64098833
Granuloma skin 23.78 9.86 85 384148 5989 64108510
Stevens-Johnson syndrome 23.68 9.86 114 384119 34135 64080364
Pyrexia 23.62 9.86 2941 381292 555703 63558796
Pleural effusion 23.46 9.86 574 383659 125985 63988514
Panniculitis 23.44 9.86 110 384123 8769 64105730
Jaundice 23.32 9.86 181 384052 48331 64066168
Drug use disorder 23.27 9.86 4 384229 6050 64108449
Acute generalised exanthematous pustulosis 22.95 9.86 30 384203 14028 64100471
Scleritis 22.89 9.86 53 384180 2913 64111586
Dyskinesia 22.88 9.86 139 384094 39249 64075250
Stillbirth 22.83 9.86 60 384173 3573 64110926
Haemorrhage 22.72 9.86 334 383899 79017 64035482
Body tinea 22.72 9.86 33 384200 1260 64113239
Hypomagnesaemia 22.72 9.86 130 384103 37246 64077253
Cerebrovascular accident 22.60 9.86 635 383598 136948 63977551
Infection susceptibility increased 22.47 9.86 50 384183 2676 64111823
Face oedema 22.47 9.86 74 384159 24687 64089812
Bronchospasm 22.41 9.86 61 384172 21621 64092878
Hyperammonaemia 22.12 9.86 16 384217 9888 64104611
Joint dislocation 21.98 9.86 130 384103 11335 64103164
Aphasia 21.90 9.86 148 384085 40758 64073741
Pancreatitis 21.89 9.86 238 383995 59369 64055130
Cardiac failure acute 21.79 9.86 40 384193 16304 64098195
Febrile bone marrow aplasia 21.67 9.86 21 384212 11234 64103265
Cyanosis 21.67 9.86 64 384169 22091 64092408
Cyst 21.55 9.86 134 384099 11893 64102606
Acute graft versus host disease in skin 21.49 9.86 7 384226 6848 64107651
White blood cell count decreased 21.43 9.86 747 383486 157090 63957409
Pulmonary alveolar haemorrhage 21.41 9.86 16 384217 9722 64104777
Potentiating drug interaction 21.35 9.86 10 384223 7842 64106657
Haemoglobin decreased 21.28 9.86 1391 382842 193672 63920827
Dactylitis 21.25 9.86 40 384193 1898 64112601
Adverse event 21.23 9.86 342 383891 39147 64075352
Pharyngitis streptococcal 21.16 9.86 105 384128 8563 64105936
Pneumatosis intestinalis 21.13 9.86 3 384230 5226 64109273
Bursitis 21 9.86 208 384025 21277 64093222
Hyperbilirubinaemia 20.92 9.86 61 384172 21144 64093355
Pemphigoid 20.91 9.86 28 384205 12958 64101541
Synovial disorder 20.89 9.86 27 384206 921 64113578
Drug hypersensitivity 20.87 9.86 1181 383052 236634 63877865
Hyperuricaemia 20.83 9.86 18 384215 10173 64104326
Endodontic procedure 20.74 9.86 44 384189 2279 64112220
Platelet count decreased 20.69 9.86 803 383430 166908 63947591
Normal newborn 20.64 9.86 77 384156 5540 64108959
Sinus tachycardia 20.63 9.86 110 384123 32078 64082421
Stress cardiomyopathy 20.62 9.86 15 384218 9242 64105257
Respiration abnormal 20.61 9.86 6 384227 6309 64108190
Breast feeding 20.53 9.86 23 384210 674 64113825
Hepatic encephalopathy 20.50 9.86 61 384172 21005 64093494
Dry eye 20.24 9.86 263 383970 28756 64085743
Hallucination, visual 20.22 9.86 91 384142 27743 64086756
Exostosis 20.22 9.86 127 384106 11311 64103188
Wrong technique in product usage process 20.20 9.86 269 383964 64705 64049794
Aspartate aminotransferase increased 20.15 9.86 551 383682 119237 63995262
Pulmonary tuberculosis 20.05 9.86 91 384142 7153 64107346
Vertigo 19.95 9.86 240 383993 58771 64055728
Cushingoid 19.93 9.86 94 384139 7509 64106990
Exposure to toxic agent 19.83 9.86 6 384227 6153 64108346
Acute myeloid leukaemia 19.82 9.86 90 384143 27373 64087126
Polyneuropathy 19.80 9.86 57 384176 19837 64094662
Endophthalmitis 19.65 9.86 4 384229 5361 64109138
Pancreatitis acute 19.63 9.86 162 384071 42693 64071806
Device use error 19.61 9.86 7 384226 6464 64108035
Depression 19.58 9.86 892 383341 182399 63932100
Incorrect route of product administration 19.54 9.86 72 384161 23226 64091273
Rebound effect 19.46 9.86 3 384230 4914 64109585
Cataract 19.25 9.86 420 383813 50842 64063657
Dyspnoea exertional 19.20 9.86 316 383917 73414 64041085
Human antichimeric antibody positive 19.10 9.86 32 384201 1384 64113115
Mass 19.09 9.86 156 384077 15120 64099379
Klebsiella infection 19.08 9.86 31 384202 13250 64101249
Lupus-like syndrome 19.04 9.86 103 384130 8688 64105811
Tardive dyskinesia 19.02 9.86 16 384217 9162 64105337
Weight decreased 18.98 9.86 1962 382271 283777 63830722
Foetal distress syndrome 18.89 9.86 18 384215 434 64114065
Nightmare 18.87 9.86 63 384170 20930 64093569
Tooth infection 18.73 9.86 150 384083 14451 64100048
Haemorrhage in pregnancy 18.72 9.86 30 384203 1250 64113249
Chronic graft versus host disease 18.66 9.86 7 384226 6269 64108230
Nocardiosis 18.66 9.86 3 384230 4764 64109735
Angina pectoris 18.62 9.86 175 384058 44906 64069593
Haemophagocytic lymphohistiocytosis 18.61 9.86 49 384184 17560 64096939
Metastases to bone 18.59 9.86 61 384172 20374 64094125
Adenovirus infection 18.58 9.86 10 384223 7245 64107254
Lipase increased 18.54 9.86 36 384197 14366 64100133
Tubulointerstitial nephritis 18.52 9.86 108 384125 30801 64083698
Induced labour 18.50 9.86 24 384209 822 64113677
Dermatitis acneiform 18.39 9.86 14 384219 8429 64106070
Ingrown hair 18.24 9.86 20 384213 572 64113927
Toxic epidermal necrolysis 18.18 9.86 138 384095 37028 64077471
Pulmonary hypertension 18.02 9.86 167 384066 42972 64071527
Hallucination, auditory 18.00 9.86 47 384186 16892 64097607
Labelled drug-drug interaction medication error 17.97 9.86 69 384164 21993 64092506
Placental disorder 17.97 9.86 24 384209 846 64113653
Bone density abnormal 17.93 9.86 46 384187 2699 64111800
Colitis ulcerative 17.91 9.86 213 384020 22815 64091684
Anhedonia 17.87 9.86 34 384199 13672 64100827
Injection site urticaria 17.85 9.86 121 384112 11060 64103439
Haematocrit decreased 17.81 9.86 439 383794 54216 64060283
Pain in jaw 17.79 9.86 156 384077 40599 64073900
Polyuria 17.70 9.86 30 384203 12613 64101886
Delusion 17.64 9.86 52 384181 17962 64096537
Lacrimal disorder 17.63 9.86 18 384215 473 64114026
Cystitis haemorrhagic 17.58 9.86 13 384220 7943 64106556
Drug-induced liver injury 17.58 9.86 190 384043 47453 64067046
Urinary retention 17.45 9.86 198 384035 49003 64065496
Bone pain 17.44 9.86 190 384043 47382 64067117
Spinal disorder 17.43 9.86 100 384133 8622 64105877
Muscle rigidity 17.43 9.86 50 384183 17423 64097076
Flushing 17.35 9.86 347 383886 78301 64036198
Musculoskeletal disorder 17.33 9.86 173 384060 17733 64096766
Acute coronary syndrome 17.32 9.86 58 384175 19252 64095247
Frequent bowel movements 17.31 9.86 176 384057 18129 64096370
Heart rate irregular 17.29 9.86 244 383989 27169 64087330
Bone density decreased 17.28 9.86 110 384123 9842 64104657
Cytopenia 17.16 9.86 42 384191 15429 64099070
Arthritis bacterial 17.08 9.86 92 384141 7747 64106752
Dislocation of vertebra 17.05 9.86 49 384184 3075 64111424
Anuria 16.98 9.86 57 384176 18907 64095592
Pleuritic pain 16.96 9.86 94 384139 8002 64106497
Affective disorder 16.96 9.86 9 384224 6571 64107928
Hyperlactacidaemia 16.95 9.86 4 384229 4840 64109659
Device difficult to use 16.95 9.86 20 384213 9778 64104721
Injection site haemorrhage 16.92 9.86 220 384013 24058 64090441
Body height below normal 16.89 9.86 35 384198 1783 64112716
Progressive multifocal leukoencephalopathy 16.88 9.86 54 384179 18178 64096321
Cytomegalovirus viraemia 16.78 9.86 24 384209 10804 64103695
Septic shock 16.71 9.86 489 383744 104948 64009551
International normalised ratio increased 16.66 9.86 352 383881 78815 64035684
Tooth abscess 16.64 9.86 140 384093 13686 64100813
Upper respiratory tract infection 16.62 9.86 559 383674 72226 64042273
Oliguria 16.62 9.86 39 384194 14537 64099962
Chest discomfort 16.57 9.86 546 383687 115560 63998939
Metastases to lung 16.49 9.86 42 384191 15222 64099277
Sexual dysfunction 16.46 9.86 9 384224 6462 64108037
Placental insufficiency 16.44 9.86 25 384208 995 64113504
Muscle spasticity 16.41 9.86 48 384185 16621 64097878
Immunosuppression 16.39 9.86 115 384118 10631 64103868
Atrioventricular block 16.38 9.86 29 384204 11986 64102513
Gestational hypertension 16.37 9.86 33 384200 1648 64112851
Epstein-Barr virus infection 16.26 9.86 31 384202 12457 64102042
Pulseless electrical activity 16.26 9.86 32 384201 12707 64101792
Renal injury 16.25 9.86 43 384190 15386 64099113
Gastric haemorrhage 16.24 9.86 35 384198 13446 64101053
Blood lactic acid increased 16.17 9.86 23 384210 10378 64104121
Atrioventricular block complete 16.10 9.86 39 384194 14379 64100120
Toothache 16.09 9.86 167 384066 17292 64097207
Wound infection pseudomonas 16.02 9.86 31 384202 1502 64112997
Sinus bradycardia 15.95 9.86 76 384157 22817 64091682
Peripheral sensory neuropathy 15.93 9.86 27 384206 11351 64103148
Hypoalbuminaemia 15.91 9.86 53 384180 17621 64096878
Acute myocardial infarction 15.87 9.86 306 383927 69412 64045087
Coronary arterial stent insertion 15.87 9.86 7 384226 5685 64108814
Electrocardiogram QRS complex prolonged 15.85 9.86 19 384214 9225 64105274
Pulmonary haemorrhage 15.82 9.86 34 384199 13075 64101424
Lymphatic fistula 15.79 9.86 21 384212 737 64113762
Femoral hernia incarcerated 15.73 9.86 21 384212 740 64113759
Kidney infection 15.68 9.86 169 384064 17669 64096830
Haematoma 15.67 9.86 188 384045 46062 64068437
Tuberculin test positive 15.67 9.86 47 384186 3021 64111478
Tooth disorder 15.61 9.86 203 384030 22199 64092300
Sciatica 15.57 9.86 187 384046 20077 64094422
Hepatitis fulminant 15.56 9.86 9 384224 6265 64108234
Maternal exposure during breast feeding 15.53 9.86 36 384197 1980 64112519
Type 2 diabetes mellitus 15.53 9.86 287 383946 33733 64080766
Cardiomyopathy 15.51 9.86 88 384145 25268 64089231
Hemiplegia 15.51 9.86 33 384200 12735 64101764
Nephropathy toxic 15.44 9.86 53 384180 17461 64097038
Arthropod bite 15.42 9.86 80 384153 6641 64107858
Off label use 15.38 9.86 3436 380797 629370 63485129
Chest pain 15.28 9.86 1204 383029 234776 63879723
Red blood cell count decreased 15.27 9.86 387 383846 47999 64066500
Cervical incompetence 15.26 9.86 17 384216 495 64114004
Metastases to liver 15.24 9.86 82 384151 23859 64090640
Cystitis 15.19 9.86 347 383886 42328 64072171
Alcohol abuse 15.13 9.86 5 384228 4847 64109652
Cardiac failure chronic 15.06 9.86 19 384214 9022 64105477
Wound infection 15.06 9.86 145 384088 14719 64099780
Joint lock 15.06 9.86 44 384189 2787 64111712
Injection site extravasation 15.06 9.86 91 384142 7995 64106504
Toxic encephalopathy 14.97 9.86 22 384211 9793 64104706
Polydipsia 14.95 9.86 8 384225 5813 64108686
Catatonia 14.93 9.86 14 384219 7606 64106893
Blood pressure decreased 14.89 9.86 395 383838 85804 64028695
Iodine allergy 14.83 9.86 17 384216 511 64113988
Hypophosphataemia 14.78 9.86 42 384191 14678 64099821
Clear cell renal cell carcinoma 14.74 9.86 37 384196 2142 64112357
Malignant mediastinal neoplasm 14.67 9.86 17 384216 517 64113982
Rheumatoid lung 14.63 9.86 40 384193 2439 64112060
Sickle cell anaemia 14.63 9.86 18 384215 584 64113915
Visual acuity reduced 14.62 9.86 98 384135 27043 64087456
Dysphagia 14.61 9.86 505 383728 106307 64008192
Abortion threatened 14.58 9.86 15 384218 398 64114101
Palpitations 14.53 9.86 493 383740 103995 64010504
Injection site discolouration 14.52 9.86 80 384153 6795 64107704
Osteopenia 14.49 9.86 149 384084 15391 64099108
Disease recurrence 14.48 9.86 119 384114 31391 64083108
Muscle twitching 14.48 9.86 61 384172 18937 64095562
Transaminases increased 14.46 9.86 183 384050 44411 64070088
Obstructive airways disorder 14.44 9.86 80 384153 23105 64091394
Hypervolaemia 14.40 9.86 152 384081 38133 64076366
Antibody test positive 14.36 9.86 39 384194 2368 64112131
Ankle arthroplasty 14.31 9.86 22 384211 884 64113615
Anger 14.31 9.86 47 384186 15694 64098805
Tendon disorder 14.27 9.86 75 384158 6257 64108242
Finger deformity 14.24 9.86 65 384168 5121 64109378
Peritoneal dialysis complication 14.21 9.86 37 384196 2191 64112308
Presyncope 14.16 9.86 137 384096 34952 64079547
Impaired quality of life 14.14 9.86 76 384157 6395 64108104
Aphthous ulcer 14.13 9.86 128 384105 12778 64101721
Interstitial lung disease 14.09 9.86 459 383774 97273 64017226
Hypercapnia 14.08 9.86 15 384218 7679 64106820
Paralysis 14.06 9.86 30 384203 11565 64102934
Joint warmth 14.03 9.86 28 384205 1388 64113111
Pulmonary congestion 14.01 9.86 84 384149 23796 64090703
Pneumothorax 13.98 9.86 86 384147 24212 64090287
Right ventricular failure 13.97 9.86 73 384160 21398 64093101
Cholestasis of pregnancy 13.97 9.86 22 384211 903 64113596
Knee operation 13.95 9.86 59 384174 4498 64110001
Ileus 13.89 9.86 80 384153 22886 64091613
Pharyngitis 13.89 9.86 174 384059 18865 64095634
Adjustment disorder with depressed mood 13.86 9.86 39 384194 2418 64112081
Dyslipidaemia 13.82 9.86 21 384212 9221 64105278
Small for dates baby 13.82 9.86 15 384218 424 64114075
Temperature regulation disorder 13.74 9.86 4 384229 4207 64110292
Foetal exposure during pregnancy 13.74 9.86 58 384175 4418 64110081
Ileus paralytic 13.70 9.86 18 384215 8397 64106102
Hypocalcaemia 13.66 9.86 171 384062 41582 64072917
End stage renal disease 13.64 9.86 26 384207 10449 64104050
Bacteraemia 13.60 9.86 99 384134 26812 64087687
Hepatitis acute 13.59 9.86 38 384195 13351 64101148
Drug specific antibody 13.57 9.86 35 384198 2060 64112439
Human anti-human antibody test 13.53 9.86 14 384219 374 64114125
Palindromic rheumatism 13.52 9.86 13 384220 317 64114182
Breast abscess 13.50 9.86 24 384209 1089 64113410
Drug abuser 13.48 9.86 9 384224 5799 64108700
Hepatitis cholestatic 13.48 9.86 33 384200 12122 64102377
Hyperthyroidism 13.47 9.86 59 384174 18120 64096379
Myocarditis 13.44 9.86 54 384179 16989 64097510
Blood calcium decreased 13.41 9.86 93 384140 25461 64089038
Eye infection 13.39 9.86 98 384135 9183 64105316
Coordination abnormal 13.39 9.86 45 384188 14919 64099580
Bradypnoea 13.38 9.86 7 384226 5152 64109347
C-reactive protein decreased 13.35 9.86 35 384198 2081 64112418
Hernia 13.27 9.86 131 384102 13387 64101112
Pseudomonas infection 13.27 9.86 58 384175 17825 64096674
Respiratory acidosis 13.24 9.86 24 384209 9831 64104668
Lung transplant 13.23 9.86 4 384229 4104 64110395
Drug screen positive 13.13 9.86 9 384224 5720 64108779
Lip swelling 13.12 9.86 124 384109 31783 64082716
Oesophageal fibrosis 13.11 9.86 10 384223 176 64114323
Hemiparesis 13.10 9.86 114 384119 29713 64084786
Foot operation 13.09 9.86 55 384178 4180 64110319
Nephrolithiasis 13.09 9.86 347 383886 43336 64071163
Delivery 13.05 9.86 16 384217 517 64113982
Metastases to central nervous system 13.02 9.86 41 384192 13871 64100628
Sinus congestion 12.99 9.86 145 384088 15294 64099205
Blood loss anaemia 12.96 9.86 41 384192 13851 64100648
Hepatotoxicity 12.95 9.86 164 384069 39798 64074701
Osteoporotic fracture 12.95 9.86 49 384184 3549 64110950
Mean cell volume increased 12.95 9.86 62 384171 4984 64109515
Increased tendency to bruise 12.94 9.86 97 384136 9158 64105341
Incoherent 12.89 9.86 14 384219 7104 64107395
Stress at work 12.88 9.86 22 384211 967 64113532
Product prescribing error 12.87 9.86 141 384092 35128 64079371
Lymphocyte count decreased 12.83 9.86 168 384065 40531 64073968
Hypernatraemia 12.82 9.86 34 384199 12155 64102344
Graft versus host disease in skin 12.80 9.86 8 384225 5339 64109160
Myopathy 12.72 9.86 58 384175 17622 64096877
Retinitis 12.66 9.86 34 384199 2051 64112448
Myofascial pain syndrome 12.66 9.86 31 384202 1767 64112732
Hepatocellular carcinoma 12.65 9.86 19 384214 8384 64106115
Abortion missed 12.62 9.86 24 384209 1148 64113351
Blood folate increased 12.60 9.86 15 384218 470 64114029
Pancreatic steatosis 12.57 9.86 22 384211 986 64113513
Serum ferritin increased 12.55 9.86 90 384143 8378 64106121
Ankylosing spondylitis 12.49 9.86 88 384145 8146 64106353
Postpartum haemorrhage 12.45 9.86 27 384206 1420 64113079
Neck pain 12.42 9.86 466 383767 61067 64053432
Anal fistula 12.38 9.86 63 384170 5190 64109309
Intracranial pressure increased 12.38 9.86 14 384219 6975 64107524
Skin ulcer haemorrhage 12.37 9.86 15 384218 479 64114020
Transplant dysfunction 12.36 9.86 13 384220 6695 64107804
Threatened labour 12.31 9.86 16 384217 549 64113950
Pneumonia bacterial 12.26 9.86 47 384186 14988 64099511
Eosinophil count increased 12.24 9.86 43 384190 14069 64100430
Spinal osteoarthritis 12.21 9.86 135 384098 14206 64100293
Sudden death 12.16 9.86 70 384163 20026 64094473
Plasma cell myeloma 12.15 9.86 197 384036 45878 64068621
Cardiotoxicity 12.11 9.86 27 384206 10247 64104252
Alanine aminotransferase increased 12.08 9.86 691 383542 138340 63976159
Lower respiratory tract congestion 12.08 9.86 42 384191 2919 64111580
Chondropathy 12.01 9.86 36 384197 2313 64112186
Hypotonia 12.00 9.86 31 384202 11181 64103318
Colitis microscopic 11.99 9.86 16 384217 7416 64107083
Erectile dysfunction 11.97 9.86 37 384196 12590 64101909
Skin neoplasm excision 11.92 9.86 20 384213 866 64113633
Lip blister 11.91 9.86 35 384198 2224 64112275
Myelosuppression 11.88 9.86 88 384145 23742 64090757
Virologic failure 11.86 9.86 3 384230 3463 64111036
Schizophrenia 11.86 9.86 31 384202 11137 64103362
Skin laceration 11.86 9.86 208 384025 24209 64090290
Amylase increased 11.79 9.86 25 384208 9660 64104839
Bradykinesia 11.77 9.86 13 384220 6547 64107952
Photophobia 11.75 9.86 156 384077 17137 64097362
Generalised tonic-clonic seizure 11.68 9.86 167 384066 39690 64074809
Therapy non-responder 11.66 9.86 492 383741 65407 64049092
Oligohydramnios 11.62 9.86 43 384190 3081 64111418
Hospitalisation 11.62 9.86 350 383883 74857 64039642
Intestinal ischaemia 11.56 9.86 33 384200 11516 64102983
Enterocolitis 11.55 9.86 35 384198 11983 64102516
Myocardial ischaemia 11.53 9.86 86 384147 23165 64091334
Cholangitis 11.46 9.86 30 384203 10772 64103727
Feeling abnormal 11.43 9.86 665 383568 132937 63981562
Vacuum extractor delivery 11.40 9.86 8 384225 123 64114376
Skin graft failure 11.40 9.86 10 384223 216 64114283
Labyrinthitis 11.40 9.86 38 384195 2585 64111914
Nephrotic syndrome 11.39 9.86 25 384208 9542 64104957
Swollen joint count 11.39 9.86 16 384217 592 64113907
Hepatitis C 11.37 9.86 31 384202 10984 64103515
Unevaluable event 11.37 9.86 222 384011 50267 64064232
Accidental death 11.34 9.86 4 384229 3721 64110778
Complication of device insertion 11.32 9.86 8 384225 5004 64109495
Abdominal distension 11.32 9.86 462 383771 95532 64018967
Mesothelioma 11.32 9.86 12 384221 330 64114169
Catheter management 11.30 9.86 3 384230 3352 64111147
Carpal tunnel syndrome 11.27 9.86 144 384089 15684 64098815
Nail injury 11.26 9.86 14 384219 459 64114040
Hypertriglyceridaemia 11.23 9.86 32 384201 11173 64103326
Skin infection 11.22 9.86 138 384095 14899 64099600
Prostatic specific antigen increased 11.18 9.86 22 384211 8738 64105761
Radiation inflammation 11.17 9.86 10 384223 222 64114277
Tooth fracture 11.15 9.86 99 384134 9828 64104671
Acute pulmonary oedema 11.13 9.86 39 384194 12770 64101729
Salivary hypersecretion 11.13 9.86 36 384197 12077 64102422
Heparin-induced thrombocytopenia 11.08 9.86 21 384212 8458 64106041
Mycobacterium tuberculosis complex test positive 11.07 9.86 32 384201 2015 64112484
Medical device site joint infection 11.06 9.86 10 384223 225 64114274
Uterine perforation 11.04 9.86 11 384222 5809 64108690
Genital haemorrhage 10.99 9.86 10 384223 5512 64108987
Diabetes mellitus inadequate control 10.99 9.86 78 384155 21243 64093256
Paranoia 10.98 9.86 55 384178 16297 64098202
Taste disorder 10.95 9.86 25 384208 9408 64105091
Oedema 10.94 9.86 442 383791 91493 64023006
Hypoxic-ischaemic encephalopathy 10.94 9.86 16 384217 7136 64107363
Sensitivity to weather change 10.92 9.86 73 384160 6641 64107858
Pancreatic duct stenosis 10.92 9.86 10 384223 229 64114270
Speech disorder developmental 10.91 9.86 15 384218 544 64113955
Skin necrosis 10.90 9.86 132 384101 14197 64100302
Cytomegalovirus chorioretinitis 10.89 9.86 8 384225 4904 64109595
Benign ovarian tumour 10.84 9.86 11 384222 287 64114212
Failed induction of labour 10.81 9.86 10 384223 232 64114267
COVID-19 pneumonia 10.80 9.86 56 384177 16448 64098051
Troponin increased 10.80 9.86 51 384182 15348 64099151
Haematemesis 10.78 9.86 206 384027 46793 64067706
Mental disorder 10.77 9.86 103 384130 26342 64088157
Hepatic cytolysis 10.77 9.86 45 384188 14004 64100495
Drug tolerance decreased 10.74 9.86 75 384158 6923 64107576
Musculoskeletal discomfort 10.72 9.86 146 384087 16131 64098368
Gastroenteritis 10.70 9.86 242 383991 29469 64085030
Hyperhomocysteinaemia 10.65 9.86 13 384220 418 64114081
Vascular insufficiency 10.65 9.86 14 384219 486 64114013
Hydrocephalus 10.64 9.86 18 384215 7573 64106926
Vascular rupture 10.62 9.86 24 384209 1298 64113201
Personality change 10.61 9.86 22 384211 8571 64105928
Type 1 diabetes mellitus 10.58 9.86 11 384222 5694 64108805
Bundle branch block left 10.54 9.86 28 384205 10006 64104493
Umbilical hernia 10.50 9.86 53 384180 4352 64110147
Diaphragmatic disorder 10.46 9.86 25 384208 1403 64113096
Hernia pain 10.44 9.86 13 384220 427 64114072
Cartilage injury 10.41 9.86 24 384209 1315 64113184
Kidney transplant rejection 10.41 9.86 26 384207 9485 64105014
Inflammatory bowel disease 10.40 9.86 54 384179 4484 64110015
Memory impairment 10.40 9.86 411 383822 85271 64029228
Decreased insulin requirement 10.38 9.86 8 384225 143 64114356
Glomerular filtration rate decreased 10.38 9.86 71 384162 19501 64094998
Clavicle fracture 10.31 9.86 47 384186 3702 64110797
Insomnia 10.22 9.86 1027 383206 196809 63917690
Complication of pregnancy 10.22 9.86 11 384222 308 64114191
Dementia 10.20 9.86 77 384156 20689 64093810
Aplasia 10.20 9.86 16 384217 6937 64107562
Device related infection 10.18 9.86 125 384108 30501 64083998
Lung neoplasm malignant 10.16 9.86 182 384051 21266 64093233
Intestinal stenosis 10.14 9.86 42 384191 3172 64111327
Aspiration 10.11 9.86 59 384174 16826 64097673
Thiopurine methyltransferase decreased 10.10 9.86 11 384222 312 64114187
Haemodynamic instability 10.10 9.86 50 384183 14862 64099637
Appendicolith 10.10 9.86 4 384229 3465 64111034
Renal disorder 10.07 9.86 149 384084 35216 64079283
Hiatus hernia 10.05 9.86 171 384062 19786 64094713
Ventricular arrhythmia 10.01 9.86 18 384215 7397 64107102
Rash erythematous 10.01 9.86 217 384016 48416 64066083
Laryngospasm 9.98 9.86 4 384229 3441 64111058
Alcohol interaction 9.98 9.86 7 384226 4394 64110105
Blood iron increased 9.97 9.86 24 384209 1353 64113146
Twin pregnancy 9.94 9.86 18 384215 829 64113670
Generalised oedema 9.93 9.86 78 384155 20775 64093724
Varicose ulceration 9.93 9.86 12 384221 382 64114117
Coronary artery bypass 9.92 9.86 12 384221 5803 64108696
Skin exfoliation 9.91 9.86 198 384035 44687 64069812
Lymphadenectomy 9.90 9.86 20 384213 1000 64113499
Ketoacidosis 9.88 9.86 16 384217 6847 64107652

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A11HA04 ALIMENTARY TRACT AND METABOLISM
VITAMINS
OTHER PLAIN VITAMIN PREPARATIONS
Other plain vitamin preparations
ATC S01XA26 SENSORY ORGANS
OPHTHALMOLOGICALS
OTHER OPHTHALMOLOGICALS
Other ophthalmologicals
MeSH PA D003879 Dermatologic Agents
MeSH PA D018977 Micronutrients
MeSH PA D017319 Photosensitizing Agents
MeSH PA D011838 Radiation-Sensitizing Agents
MeSH PA D014803 Vitamin B Complex
MeSH PA D014815 Vitamins
CHEBI has role CHEBI:22586 antioxidants
CHEBI has role CHEBI:23357 cofactor
CHEBI has role CHEBI:47868 photosensitising agent
CHEBI has role CHEBI:67079 anti-inflammatory agents
CHEBI has role CHEBI:75771 Mus musculus metabolites
CHEBI has role CHEBI:76924 plant metabolites
CHEBI has role CHEBI:76971 Escherichia coli metabolites
CHEBI has role CHEBI:77182 food coloring
CHEBI has role CHEBI:78675 fundamental metabolites
CHEBI has role CHEBI:84087 human urinary metabolites
CHEBI has role CHEBI:75772 S. cerevisiae metabolites

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Vitamin deficiency indication 85670002
Mineral deficiency indication 111379007
Vitamin Deficiency Prevention indication
Mineral Deficiency Prevention indication
Glutaric aciduria, type 2 off-label use 22886006 DOID:0060358
Glutaric aciduria, type 1 off-label use 76175005
Migraine Prevention off-label use
Necrotizing enterocolitis in fetus OR newborn contraindication 2707005
Alcoholism contraindication 7200002
Peptic ulcer contraindication 13200003 DOID:750
Myocardial infarction contraindication 22298006 DOID:5844
Obstruction of bile duct contraindication 30144000
Hypertensive disorder contraindication 38341003 DOID:10763
Gastrointestinal ulcer contraindication 40845000
Hypokalemia contraindication 43339004
Conduction disorder of the heart contraindication 44808001
Low blood pressure contraindication 45007003
Chronic heart failure contraindication 48447003
Gastrointestinal perforation contraindication 51875005
Gastrectomy contraindication 53442002
Leber's optic atrophy contraindication 58610003 DOID:705
Hepatic failure contraindication 59927004
Blood coagulation disorder contraindication 64779008 DOID:1247
Agoraphobia contraindication 70691001 DOID:593
Gastrointestinal hemorrhage contraindication 74474003
Atrophic gastritis contraindication 84568007 DOID:8929
Kidney disease contraindication 90708001 DOID:557
Hemophilia contraindication 90935002
Seizure disorder contraindication 128613002
Obsessive-compulsive disorder contraindication 191736004 DOID:10933
Insomnia contraindication 193462001
Impaired renal function disorder contraindication 197663003
Coronary artery bypass graft contraindication 232717009
Disease of liver contraindication 235856003 DOID:409
Pregnancy, function contraindication 289908002
Panic disorder contraindication 371631005 DOID:594
Cardiovascular event risk contraindication 395112001
Myocardial ischemia contraindication 414795007 DOID:3393
Myocardial infarction in recovery phase contraindication 418044006
Smokes tobacco daily contraindication 449868002
Acute Thromboembolic Stroke contraindication




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 10.13 acidic
pKa2 11.89 acidic
pKa3 13.48 acidic
pKa4 2.49 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Flavin reductase (NADPH) Enzyme WOMBAT-PK
Riboflavin kinase Kinase WOMBAT-PK
Riboflavin-binding protein Unclassified Kd 8.30 CHEMBL

External reference:

IDSource
4017778 VUID
N0000146139 NUI
D00050 KEGG_DRUG
4017633 VANDF
4017778 VANDF
4021901 VANDF
CHEBI:57986 CHEBI
RBF PDB_CHEM_ID
CHEMBL1534 ChEMBL_ID
CHEMBL1397833 ChEMBL_ID
6578 IUPHAR_LIGAND_ID
419 INN_ID
DB00140 DRUGBANK_ID
TLM2976OFR UNII
493570 PUBCHEM_CID
9346 RXNORM
5060 MMSL
5062 MMSL
5422 MMSL
5683 MMSL
d00409 MMSL
001059 NDDF
13235001 SNOMEDCT_US
329260009 SNOMEDCT_US
D012256 MESH_DESCRIPTOR_UI
C0035527 UMLSCUI

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
NataFort HUMAN PRESCRIPTION DRUG LABEL 10 0178-0716 TABLET 3 mg ORAL Unapproved drug other 12 sections
CitraNatal 90 DHA HUMAN PRESCRIPTION DRUG LABEL 16 0178-0821 TABLET 3.40 mg ORAL unapproved drug other 11 sections
CitraNatal Rx HUMAN PRESCRIPTION DRUG LABEL 13 0178-0858 TABLET 3.40 mg ORAL Unapproved drug other 12 sections
CitraNatal Rx HUMAN PRESCRIPTION DRUG LABEL 14 0178-0859 TABLET 3.40 mg ORAL Unapproved drug other 9 sections
CitraNatal DHA HUMAN OTC DRUG LABEL 14 0178-0898 TABLET 3.40 mg ORAL Unapproved drug other 11 sections
VitafolOne HUMAN PRESCRIPTION DRUG LABEL 16 0642-0070 CAPSULE, GELATIN COATED 1.80 mg ORAL unapproved drug other 14 sections
Vitafol Caplet HUMAN PRESCRIPTION DRUG LABEL 12 0642-0072 CAPSULE 1.80 mg ORAL UNAPPROVED DRUG OTHER 13 sections
Select OB HUMAN PRESCRIPTION DRUG LABEL 15 0642-0077 TABLET, CHEWABLE 1.80 mg ORAL UNAPPROVED DRUG OTHER 14 sections
Vitafol OB Caplet HUMAN PRESCRIPTION DRUG LABEL 15 0642-0079 TABLET 1.80 mg ORAL Unapproved drug other 14 sections
Vitafol Plus HUMAN PRESCRIPTION DRUG LABEL 17 0642-0092 CAPSULE, LIQUID FILLED 1.80 mg ORAL UNAPPROVED DRUG OTHER 13 sections
Vitafol Ultra HUMAN PRESCRIPTION DRUG LABEL 17 0642-0093 CAPSULE, LIQUID FILLED 1.80 mg ORAL UNAPPROVED DRUG OTHER 13 sections
Select OB HUMAN PRESCRIPTION DRUG LABEL 15 0642-0120 TABLET, CHEWABLE 1.80 mg ORAL UNAPPROVED DRUG OTHER 13 sections
Strovite Forte Caplet HUMAN PRESCRIPTION DRUG LABEL 19 0642-0204 TABLET, COATED 20 mg ORAL UNAPPROVED DRUG OTHER 15 sections
Strovite One Caplets HUMAN PRESCRIPTION DRUG LABEL 20 0642-0207 TABLET 5 mg ORAL UNAPPROVED DRUG OTHER 14 sections
Reaphirm Plant Source DHA HUMAN PRESCRIPTION DRUG LABEL 16 0642-3010 CAPSULE, GELATIN COATED 1.80 mg ORAL unapproved drug other 7 sections
Vitafol Fe Plus HUMAN PRESCRIPTION DRUG LABEL 17 0642-7473 CAPSULE, LIQUID FILLED 1.80 mg ORAL UNAPPROVED DRUG OTHER 14 sections
Marnatal F HUMAN PRESCRIPTION DRUG LABEL 13 0682-1570 CAPSULE 3.40 mg ORAL UNAPPROVED DRUG OTHER 4 sections
BACMIN HUMAN PRESCRIPTION DRUG LABEL 19 0682-3001 TABLET, COATED 20 mg ORAL UNAPPROVED DRUG OTHER 10 sections
O-Cal Prenatal Vitamin HUMAN PRESCRIPTION DRUG LABEL 16 0813-0202 TABLET 1.60 mg ORAL UNAPPROVED DRUG OTHER 6 sections
Dialyvite Supreme D HUMAN PRESCRIPTION DRUG LABEL 13 10542-009 TABLET, COATED 1.70 mg ORAL Unapproved drug other 7 sections
Dialyvite HUMAN PRESCRIPTION DRUG LABEL 9 10542-010 TABLET, COATED 1.70 mg ORAL Unapproved drug other 7 sections
Dialyvite 5000 HUMAN PRESCRIPTION DRUG LABEL 12 10542-011 TABLET, COATED 1.70 mg ORAL Unapproved drug other 7 sections
Dialyvite with Zinc HUMAN PRESCRIPTION DRUG LABEL 10 10542-012 TABLET, COATED 1.70 mg ORAL Unapproved drug other 7 sections
Dialyvite 3000 HUMAN PRESCRIPTION DRUG LABEL 12 10542-014 TABLET, COATED 1.70 mg ORAL Unapproved drug other 7 sections
PRENATAL PLUS HUMAN PRESCRIPTION DRUG LABEL 15 10544-549 TABLET, FILM COATED 3 mg ORAL unapproved drug other 8 sections
PRENATAL PLUS IRON HUMAN PRESCRIPTION DRUG LABEL 15 10544-609 TABLET, FILM COATED 3 mg ORAL UNAPPROVED DRUG OTHER 7 sections
Se-Natal 19 HUMAN PRESCRIPTION DRUG LABEL 15 13925-116 TABLET 3 mg ORAL unapproved drug other 15 sections
Se-Natal 19 HUMAN PRESCRIPTION DRUG LABEL 15 13925-116 TABLET 3 mg ORAL unapproved drug other 15 sections
Se-Natal 19 Chewable HUMAN PRESCRIPTION DRUG LABEL 14 13925-117 TABLET, CHEWABLE 3 mg ORAL unapproved drug other 16 sections
Se-Tan PLUS HUMAN PRESCRIPTION DRUG LABEL 13 13925-118 CAPSULE, GELATIN COATED 6 mg ORAL unapproved drug other 19 sections