thiamine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
2832 59-43-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • thiamine
  • vitamin B1
  • thiamine hydrochloride
  • thiamine mononitrate
  • thiamine (vit B1)
  • thiamine HCl
3-((4-Amino-2-methyl-5-pyrimidinyl)methyl)-5-(2- hydroxyethyl)-4-methylthiazolium chloride.
  • Molecular weight: 265.35
  • Formula: C12H17N4OS
  • CLOGP: -5.67
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 2
  • TPSA: 75.91
  • ALOGS: -4.29
  • ROTB: 4
  • Status: OFP
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
50 mg O
50 mg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 500 mg/mL Bocci G, Oprea TI, Benet LZ
EoM (Fraction excreted unchanged in urine) 90 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 5.55 µM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 4.50 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2B,BRAF,EIF2AK3,GRK2,MAPK7,PDK1,PDK2,PRKDC 8
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

DateAgencyCompanyOrphan
Dec. 29, 1993 FDA HOSPIRA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Pemphigus 1661.04 10.15 6508 797489 320356 89504094
Systemic lupus erythematosus 1641.49 10.15 6956 797041 354940 89469510
Glossodynia 1410.85 10.15 6123 797874 315656 89508794
Hand deformity 1171.63 10.15 5470 798527 290892 89533558
Arthropathy 1142.00 10.15 6323 797674 359919 89464531
Alopecia 1021.94 10.15 7700 796297 487371 89337079
Abdominal discomfort 1021.53 10.15 7488 796509 469840 89354610
Completed suicide 966.38 10.15 87 803910 144971 89679479
Wound 958.78 10.15 5253 798744 297727 89526723
Toxicity to various agents 878.17 10.15 757 803240 287089 89537361
Synovitis 846.09 10.15 5411 798586 324341 89500109
Maternal exposure during pregnancy 813.15 10.15 5724 798273 354339 89470111
Anti-cyclic citrullinated peptide antibody positive 794.32 10.15 4168 799829 232265 89592185
Swelling 781.83 10.15 6369 797628 412689 89411761
Pericarditis 779.31 10.15 4570 799427 265581 89558869
Discomfort 713.48 10.15 4518 799479 269817 89554633
Contraindicated product administered 691.62 10.15 5036 798961 315103 89509347
Joint swelling 647.20 10.15 7067 796930 496233 89328217
Duodenal ulcer perforation 635.71 10.15 3740 800257 217548 89606902
Infusion related reaction 606.95 10.15 6003 797994 410777 89413673
Helicobacter infection 582.18 10.15 3724 800273 223126 89601324
Death 579.86 10.15 2090 801907 454461 89369989
Intentional overdose 535.94 10.15 93 803904 93741 89730709
Drug interaction 512.15 10.15 1051 802946 275402 89549048
Rheumatoid arthritis 508.92 10.15 5184 798813 357430 89467020
Rheumatoid factor positive 477.31 10.15 2877 801120 168773 89655677
Pain 446.30 10.15 11774 792223 984567 88839883
Psoriatic arthropathy 424.19 10.15 3469 800528 224866 89599584
Febrile neutropenia 422.91 10.15 468 803529 157881 89666569
Hepatic enzyme increased 398.97 10.15 4922 799075 355814 89468636
Drug abuse 395.82 10.15 119 803878 82228 89742222
Therapeutic product effect decreased 365.87 10.15 3919 800078 273652 89550798
Malignant neoplasm progression 345.57 10.15 265 803732 106605 89717845
Musculoskeletal stiffness 343.42 10.15 4082 799915 292450 89532000
Arthralgia 342.61 10.15 9182 794815 769340 89055110
Suicide attempt 341.19 10.15 121 803876 75278 89749172
Disease progression 337.62 10.15 542 803455 156073 89668377
Product use issue 333.14 10.15 4427 799570 325492 89498958
Impaired healing 330.46 10.15 3353 800644 230846 89593604
Constipation 328.13 10.15 1326 802671 279069 89545381
Depressed level of consciousness 318.91 10.15 123 803874 72661 89751789
Neutropenia 301.63 10.15 1005 802992 223899 89600551
Folliculitis 300.00 10.15 2950 801047 201403 89623047
Rheumatic fever 298.72 10.15 2353 801644 150768 89673682
Blister 280.23 10.15 3476 800521 251522 89572928
Overdose 270.82 10.15 625 803372 157084 89667366
Acute kidney injury 264.71 10.15 1709 802288 318678 89505772
Drug intolerance 258.86 10.15 5484 798513 442107 89382343
Muscle injury 247.58 10.15 2526 801471 174128 89650322
Cardiac arrest 245.67 10.15 343 803654 104592 89719858
Sleep disorder due to general medical condition, insomnia type 237.58 10.15 1953 802044 126741 89697709
Exposure during pregnancy 237.52 10.15 3192 800805 235218 89589232
Swollen joint count increased 234.80 10.15 1741 802256 109465 89714985
Irritable bowel syndrome 230.50 10.15 2834 801163 204614 89619836
Type 2 diabetes mellitus 227.74 10.15 2781 801216 200463 89623987
Nausea 226.44 10.15 7826 796171 1102490 88721960
Hyperhidrosis 223.05 10.15 554 803443 135751 89688699
Fibromyalgia 222.78 10.15 2803 801194 203466 89620984
Hypersensitivity 219.65 10.15 5432 798565 449245 89375205
Treatment failure 216.71 10.15 3845 800152 300083 89524367
Hypotension 214.70 10.15 1849 802148 323548 89500902
Hip arthroplasty 209.53 10.15 1274 802723 74934 89749516
Somnolence 208.94 10.15 1048 802949 208036 89616414
Lactic acidosis 208.61 10.15 93 803904 50370 89774080
Lower respiratory tract infection 208.45 10.15 3252 800745 247407 89577043
Nasopharyngitis 206.65 10.15 4897 799100 402207 89422243
Knee arthroplasty 204.78 10.15 1352 802645 81830 89742620
C-reactive protein abnormal 204.01 10.15 1874 802123 125555 89698895
Sedation 201.94 10.15 87 803910 48084 89776366
Blood cholesterol increased 198.16 10.15 2763 801234 205249 89619201
Electrocardiogram QT prolonged 195.74 10.15 212 803785 72244 89752206
Cardiac failure 191.14 10.15 430 803567 109066 89715384
Ill-defined disorder 185.13 10.15 2478 801519 182413 89642037
Drug ineffective for unapproved indication 184.51 10.15 191 803806 66453 89757997
Bradycardia 174.29 10.15 297 803700 83550 89740900
Hyponatraemia 173.32 10.15 605 803392 132933 89691517
Neoplasm progression 171.67 10.15 90 803907 44396 89780054
Myelosuppression 169.29 10.15 136 803861 53455 89770995
Liver injury 166.63 10.15 2276 801721 168291 89656159
Red blood cell sedimentation rate abnormal 165.47 10.15 532 803465 23672 89800778
Renal failure 163.08 10.15 604 803393 130403 89694047
Stomatitis 162.87 10.15 3379 800618 271319 89553131
Drug reaction with eosinophilia and systemic symptoms 162.80 10.15 88 803909 42670 89781780
Contusion 156.82 10.15 3114 800883 248102 89576348
Serotonin syndrome 154.77 10.15 71 803926 37816 89786634
Agitation 153.39 10.15 223 803774 66875 89757575
Cognitive disorder 151.59 10.15 238 803759 69169 89755281
Tremor 150.57 10.15 772 803225 152401 89672049
Osteoarthritis 150.16 10.15 2506 801491 193224 89631226
Rhabdomyolysis 148.67 10.15 141 803856 51115 89773335
Anaemia 148.53 10.15 2218 801779 350584 89473866
Diarrhoea 147.55 10.15 6821 797176 932369 88892081
Sopor 146.13 10.15 22 803975 24622 89799828
Syncope 142.38 10.15 648 803349 132015 89692435
Chest discomfort 140.78 10.15 689 803308 137676 89686774
Thrombocytopenia 140.73 10.15 1179 802818 207546 89616904
Renal impairment 139.24 10.15 474 803523 104947 89719503
Off label use 138.76 10.15 8187 795810 1094065 88730385
Sickle cell anaemia with crisis 137.93 10.15 239 803758 7058 89817392
Injury 132.56 10.15 2474 801523 194875 89629575
Intentional product use issue 129.84 10.15 2672 801325 214220 89610230
Hypoglycaemia 129.63 10.15 265 803732 69583 89754867
No adverse event 129.53 10.15 254 803743 67728 89756722
Angioedema 128.33 10.15 237 803760 64639 89759811
Respiratory arrest 126.18 10.15 69 803928 33242 89791208
Intentional self-injury 126.14 10.15 51 803946 29283 89795167
Macular degeneration 125.48 10.15 92 803905 37878 89786572
Neuropathy peripheral 125.39 10.15 707 803290 136263 89688187
Pregnancy 125.07 10.15 961 803036 61086 89763364
Drug resistance 124.47 10.15 57 803940 30392 89794058
Coma 123.70 10.15 289 803708 72343 89752107
Myalgia 123.63 10.15 977 803020 174148 89650302
Neutrophil count decreased 121.52 10.15 285 803712 71247 89753203
Respiratory failure 120.27 10.15 590 803407 117828 89706622
Hepatic function abnormal 118.96 10.15 141 803856 46147 89778303
Intentional product misuse 118.25 10.15 403 803594 89201 89735249
General physical health deterioration 117.22 10.15 4046 799951 351069 89473381
Joint range of motion decreased 116.16 10.15 1769 802228 133874 89690576
Cardio-respiratory arrest 115.10 10.15 242 803755 62898 89761552
Cytokine release syndrome 114.92 10.15 52 803945 27921 89796529
Facet joint syndrome 112.60 10.15 1352 802645 97037 89727413
Grip strength decreased 111.20 10.15 1284 802713 91292 89733158
Sedation complication 110.57 10.15 11 803986 16933 89807517
Live birth 109.22 10.15 1128 802869 77979 89746471
Device expulsion 108.91 10.15 121 803876 40765 89783685
Hyperglycaemia 108.27 10.15 178 803819 50792 89773658
Orthostatic hypotension 107.93 10.15 127 803870 41700 89782750
COVID-19 107.88 10.15 967 803030 167876 89656574
Sinusitis 107.78 10.15 3887 800110 339201 89485249
Weight increased 107.69 10.15 4634 799363 413293 89411157
Multiple organ dysfunction syndrome 106.94 10.15 284 803713 68052 89756398
Palpitations 106.43 10.15 742 803255 135986 89688464
Fatigue 106.06 10.15 11736 792261 1142287 88682163
Accidental exposure to product 105.76 10.15 132 803865 42234 89782216
Tachycardia 105.64 10.15 892 803105 156781 89667669
Inflammation 104.84 10.15 2194 801803 176398 89648052
White blood cell count decreased 103.33 10.15 965 803032 166144 89658306
Vision blurred 103.29 10.15 565 803432 109728 89714722
Peripheral swelling 102.98 10.15 4565 799432 408541 89415909
Metabolic acidosis 101.82 10.15 213 803784 55463 89768987
Metastases to bone 100.80 10.15 50 803947 25455 89798995
Dry skin 100.70 10.15 420 803577 87653 89736797
Pulmonary fibrosis 100.29 10.15 1423 802574 106080 89718370
Hypoxia 100.10 10.15 319 803678 72080 89752370
Blood glucose increased 99.95 10.15 469 803528 94777 89729673
Dyspnoea 99.88 10.15 6605 797392 874350 88950100
Dysphagia 99.30 10.15 586 803411 111692 89712758
Balance disorder 98.98 10.15 483 803514 96597 89727853
Mobility decreased 98.69 10.15 2918 801079 247816 89576634
Multiple sclerosis relapse 98.29 10.15 197 803800 52108 89772342
Anaphylactic reaction 97.23 10.15 422 803575 87102 89737348
Altered state of consciousness 95.91 10.15 83 803914 31449 89793001
Seizure 95.39 10.15 879 803118 151750 89672700
Condition aggravated 94.70 10.15 6311 797686 589234 89235216
Lip dry 94.44 10.15 1337 802660 99618 89724832
Rash 93.68 10.15 8238 795759 787862 89036588
Erythema 92.04 10.15 1454 802543 227792 89596658
Food allergy 91.91 10.15 56 803941 25422 89799028
Anaphylactic shock 91.67 10.15 87 803910 31530 89792920
Creatinine renal clearance decreased 91.37 10.15 27 803970 18872 89805578
Temperature regulation disorder 91.24 10.15 11 803986 14568 89809882
Deep vein thrombosis postoperative 90.89 10.15 995 803002 69814 89754636
Dehydration 90.78 10.15 1197 802800 193250 89631200
Product dose omission issue 90.52 10.15 1935 802062 289752 89534698
Palmar-plantar erythrodysaesthesia syndrome 89.91 10.15 70 803927 27953 89796497
Hepatocellular injury 89.58 10.15 75 803922 28883 89795567
Platelet count decreased 89.45 10.15 780 803217 136189 89688261
Infection 89.27 10.15 3997 800000 358097 89466353
Blood pressure systolic abnormal 89.15 10.15 376 803621 19102 89805348
Blood pressure diastolic abnormal 88.85 10.15 381 803616 19500 89804950
Drug withdrawal syndrome 86.89 10.15 76 803921 28647 89795803
Hepatic failure 86.02 10.15 137 803860 39591 89784859
Feeling abnormal 84.61 10.15 1012 802985 166223 89658227
Wrong technique in product usage process 84.52 10.15 337 803660 71234 89753216
Restlessness 84.34 10.15 116 803881 35604 89788846
Vomiting 83.50 10.15 5945 798052 782348 89042102
Dysarthria 83.31 10.15 229 803768 54253 89770197
Hyperkalaemia 83.14 10.15 296 803701 64668 89759782
Suicidal ideation 82.70 10.15 355 803642 73500 89750950
Cardiac failure congestive 82.63 10.15 524 803473 98170 89726280
Skin exfoliation 82.61 10.15 316 803681 67597 89756853
Asthenia 81.59 10.15 3886 800111 529865 89294585
Shock 81.33 10.15 81 803916 28697 89795753
Ejection fraction decreased 81.20 10.15 68 803929 26185 89798265
Drug dependence 80.10 10.15 85 803912 29242 89795208
Cytomegalovirus infection 79.73 10.15 71 803926 26531 89797919
Anxiety 79.00 10.15 2117 801880 307655 89516795
Leukopenia 78.63 10.15 546 803451 100164 89724286
Disability assessment scale score increased 78.58 10.15 132 803865 3799 89820651
Colitis 77.82 10.15 337 803660 69605 89754845
Blood calcium decreased 76.43 10.15 93 803904 30089 89794361
Rash erythematous 75.96 10.15 308 803689 64796 89759654
Metastases to liver 75.91 10.15 86 803911 28721 89795729
Back pain 75.90 10.15 2187 801810 314988 89509462
Encephalopathy 75.76 10.15 189 803808 46255 89778195
Ventricular tachycardia 75.20 10.15 65 803932 24643 89799807
Obesity 75.12 10.15 1335 802662 104172 89720278
Hallucination 75.12 10.15 315 803682 65644 89758806
Abortion spontaneous 74.23 10.15 770 803227 53286 89771164
Cholestasis 74.12 10.15 130 803867 36169 89788281
Personality disorder 74.03 10.15 11 803986 12433 89812017
Joint effusion 73.41 10.15 358 803639 19352 89805098
Mydriasis 73.39 10.15 21 803976 14991 89809459
Sepsis 73.00 10.15 1138 802859 178676 89645774
Foot deformity 72.36 10.15 829 803168 58822 89765628
Product use in unapproved indication 71.76 10.15 2354 801643 333882 89490568
Autoimmune disorder 71.22 10.15 1015 802982 75729 89748721
Blood pressure decreased 71.04 10.15 382 803615 74513 89749937
Wound infection 70.74 10.15 1332 802665 105070 89719380
Cough 70.72 10.15 2618 801379 366344 89458106
Disturbance in attention 70.56 10.15 200 803797 46909 89777541
Arthritis 68.76 10.15 1958 802039 165357 89659093
Adjustment disorder with depressed mood 68.07 10.15 787 803210 55966 89768484
Flushing 67.98 10.15 482 803515 88009 89736441
Osteonecrosis of jaw 67.86 10.15 154 803843 38949 89785501
C-reactive protein increased 67.58 10.15 2097 801900 179292 89645158
Dislocation of vertebra 67.53 10.15 777 803220 55191 89769259
Diabetic ketoacidosis 67.49 10.15 70 803927 24337 89800113
Extrapyramidal disorder 67.45 10.15 30 803967 16273 89808177
Schizophrenia 67.35 10.15 24 803973 14890 89809560
Device difficult to use 66.81 10.15 36 803961 17489 89806961
Drug level increased 66.71 10.15 89 803908 27673 89796777
Red blood cell sedimentation rate increased 66.43 10.15 1066 802931 81529 89742921
Blood pressure systolic increased 66.41 10.15 801 803196 57544 89766906
Gamma-glutamyltransferase increased 65.43 10.15 150 803847 37802 89786648
Blood creatine phosphokinase increased 64.91 10.15 127 803870 33896 89790554
Disease recurrence 64.77 10.15 149 803848 37504 89786946
Hypercholesterolaemia 64.34 10.15 1255 802742 99637 89724813
Sciatica 64.28 10.15 1260 802737 100122 89724328
Pulmonary embolism 64.12 10.15 797 803200 130023 89694427
Respiratory depression 63.90 10.15 29 803968 15546 89808904
Neurotoxicity 63.50 10.15 58 803939 21409 89803041
Myocardial infarction 62.92 10.15 618 803379 105354 89719096
Foetal exposure during pregnancy 62.77 10.15 620 803377 42355 89782095
Torsade de pointes 62.71 10.15 28 803969 15154 89809296
Metastases to central nervous system 62.66 10.15 39 803958 17503 89806947
Blood pressure fluctuation 62.50 10.15 726 803271 51687 89772763
Gait inability 62.44 10.15 1722 802275 144734 89679716
Blood creatinine increased 62.00 10.15 587 803410 100799 89723651
Aphasia 61.76 10.15 185 803812 42627 89781823
Cerebral haemorrhage 61.51 10.15 134 803863 34388 89790062
Poisoning 61.40 10.15 29 803968 15188 89809262
Parkinsonism 61.22 10.15 24 803973 14041 89810409
Joint destruction 61.21 10.15 257 803740 13030 89811420
Breast cancer stage III 61.00 10.15 1071 802926 83376 89741074
Musculoskeletal pain 60.96 10.15 1969 802028 169282 89655168
Dermatitis atopic 60.85 10.15 71 803926 23401 89801049
Loss of consciousness 60.53 10.15 877 803120 139361 89685089
Ascites 60.11 10.15 219 803778 47521 89776929
Therapy partial responder 60.08 10.15 64 803933 21979 89802471
Acute hepatic failure 59.84 10.15 67 803930 22494 89801956
Hypokalaemia 59.05 10.15 813 803184 130303 89694147
Juvenile idiopathic arthritis 58.55 10.15 117 803880 3860 89820590
Peripheral venous disease 58.37 10.15 1058 802939 82863 89741587
Exposure to toxic agent 58.20 10.15 3 803994 7964 89816486
Gastrointestinal disorder 58.16 10.15 2810 801187 253877 89570573
Hemiparesis 57.95 10.15 122 803875 31697 89792753
Hypothermia 57.92 10.15 33 803964 15542 89808908
Bone erosion 57.79 10.15 722 803275 52299 89772151
Blood bilirubin increased 57.69 10.15 195 803802 43275 89781175
Hemiplegia 57.62 10.15 36 803961 16124 89808326
Fluid retention 57.35 10.15 502 803495 87589 89736861
Disorientation 57.12 10.15 200 803797 43914 89780536
Road traffic accident 57.01 10.15 1303 802694 106323 89718127
Blood alkaline phosphatase increased 57.01 10.15 226 803771 47853 89776597
Adverse event 56.85 10.15 1404 802593 116014 89708436
Vertigo 56.72 10.15 374 803623 69437 89755013
Carotid artery thrombosis 56.55 10.15 7 803990 9085 89815365
Chronic sinusitis 56.49 10.15 77 803920 23725 89800725
Aspartate aminotransferase increased 56.32 10.15 612 803385 102325 89722125
Unresponsive to stimuli 56.24 10.15 163 803834 37958 89786492
Emotional distress 56.13 10.15 154 803843 36508 89787942
Exposure via skin contact 56.12 10.15 13 803984 10692 89813758
Nasal polyps 55.50 10.15 14 803983 10866 89813584
Posterior reversible encephalopathy syndrome 55.34 10.15 70 803927 22269 89802181
Cerebrovascular accident 55.27 10.15 767 803230 122766 89701684
Skin haemorrhage 55.07 10.15 65 803932 21315 89803135
Bursitis 55.01 10.15 1544 802453 130110 89694340
Hypomania 54.97 10.15 7 803990 8890 89815560
Thrombotic microangiopathy 54.86 10.15 36 803961 15707 89808743
Pain in jaw 54.74 10.15 229 803768 47756 89776694
Bone pain 54.53 10.15 324 803673 61659 89762791
Dysgeusia 54.44 10.15 260 803737 52300 89772150
Polyarthritis 54.43 10.15 313 803684 18037 89806413
Dizziness 54.42 10.15 4494 799503 584790 89239660
Procedural pain 54.22 10.15 136 803861 33224 89791226
Atrial fibrillation 54.08 10.15 846 803151 132765 89691685
Disseminated intravascular coagulation 53.87 10.15 67 803930 21471 89802979
Eating disorder 53.37 10.15 105 803892 27968 89796482
Pulmonary oedema 53.30 10.15 327 803670 61753 89762697
Angina pectoris 53.11 10.15 174 803823 38986 89785464
Polyneuropathy 52.89 10.15 56 803941 19285 89805165
Headache 52.00 10.15 6783 797214 855963 88968487
Proteinuria 51.68 10.15 79 803918 23212 89801238
Chronic kidney disease 51.57 10.15 249 803748 49942 89774508
Prescribed underdose 51.55 10.15 944 803053 74075 89750375
Psychotic disorder 51.00 10.15 127 803870 31103 89793347
Joint laxity 50.88 10.15 87 803910 2541 89821909
Basal cell carcinoma 50.87 10.15 486 803511 32903 89791547
Withdrawal syndrome 50.36 10.15 76 803921 22448 89802002
Respiratory distress 50.13 10.15 177 803820 38769 89785681
Mental status changes 49.87 10.15 215 803782 44464 89779986
Second primary malignancy 49.85 10.15 15 803982 10363 89814087
Premature labour 49.85 10.15 243 803754 13133 89811317
Depressed mood 49.39 10.15 253 803744 49969 89774481
Bronchospasm 49.14 10.15 67 803930 20642 89803808
Hepatotoxicity 49.11 10.15 224 803773 45618 89778832
Brain oedema 49.05 10.15 49 803948 17336 89807114
Alanine aminotransferase increased 49.01 10.15 746 803251 117592 89706858
Miosis 48.77 10.15 12 803985 9472 89814978
Toxic skin eruption 48.61 10.15 41 803956 15733 89808717
Gestational diabetes 48.22 10.15 204 803793 10378 89814072
Lower limb fracture 47.79 10.15 1038 802959 83975 89740475
Joint stiffness 47.48 10.15 964 803033 77078 89747372
Haematotoxicity 47.42 10.15 26 803971 12509 89811941
Muscle spasticity 47.18 10.15 158 803839 35164 89789286
Paraesthesia oral 46.97 10.15 135 803862 31524 89792926
Pancreatitis acute 46.88 10.15 138 803859 31977 89792473
Diabetes mellitus inadequate control 46.86 10.15 58 803939 18626 89805824
Swollen tongue 46.05 10.15 230 803767 45726 89778724
Coordination abnormal 45.90 10.15 74 803923 21282 89803168
Dyskinesia 45.73 10.15 168 803829 36366 89788084
Sleep disorder 45.71 10.15 2172 801825 195858 89628592
Akathisia 45.44 10.15 21 803976 11138 89813312
Abnormal behaviour 45.34 10.15 82 803915 22546 89801904
Metastases to lung 45.20 10.15 45 803952 15946 89808504
Status epilepticus 44.85 10.15 61 803936 18813 89805637
Pleural effusion 44.68 10.15 711 803286 111280 89713170
Arrhythmia 44.67 10.15 208 803789 42124 89782326
Eczema 44.61 10.15 280 803717 52590 89771860
Multiple drug therapy 44.58 10.15 5 803992 7004 89817446
Caesarean section 44.52 10.15 300 803697 18277 89806173
Adjustment disorder 44.43 10.15 15 803982 9627 89814823
Affect lability 44.33 10.15 57 803940 18006 89806444
Arterial occlusive disease 44 10.15 28 803969 12418 89812032
Cytopenia 43.93 10.15 54 803943 17395 89807055
Ventricular fibrillation 43.90 10.15 36 803961 14008 89810442
Psoriasis 43.89 10.15 1664 802333 146090 89678360
Face oedema 43.66 10.15 88 803909 23230 89801220
Speech disorder 43.50 10.15 232 803765 45353 89779097
Acute respiratory failure 43.46 10.15 214 803783 42704 89781746
Illness 43.38 10.15 491 803506 81478 89742972
Injection site reaction 43.37 10.15 1097 802900 90983 89733467
Rhinitis allergic 43.27 10.15 51 803946 16734 89807716
Bronchopulmonary aspergillosis 42.60 10.15 24 803973 11374 89813076
Loss of personal independence in daily activities 42.16 10.15 1540 802457 134565 89689885
Transplant rejection 42.04 10.15 31 803966 12727 89811723
Aggression 41.59 10.15 111 803886 26557 89797893
Drug tolerance decreased 41.46 10.15 452 803545 31678 89792772
C-reactive protein 41.27 10.15 443 803554 30924 89793526
Tachypnoea 41.12 10.15 79 803918 21230 89803220
Mania 40.79 10.15 39 803958 14085 89810365
Eye pruritus 40.75 10.15 127 803870 28900 89795550
Inappropriate antidiuretic hormone secretion 40.60 10.15 69 803928 19436 89805014
Dystonia 40.33 10.15 54 803943 16765 89807685
Osteoporosis 40.29 10.15 1132 802865 95399 89729051
Obstructive airways disorder 40.10 10.15 108 803889 25761 89798689
Forced expiratory volume decreased 40.00 10.15 3 803994 5805 89818645
Haemophagocytic lymphohistiocytosis 39.82 10.15 47 803950 15412 89809038
Dry mouth 39.80 10.15 2006 801991 182053 89642397
Stress cardiomyopathy 39.60 10.15 36 803961 13319 89811131
Acute generalised exanthematous pustulosis 39.38 10.15 38 803959 13665 89810785
Haemorrhage 39.33 10.15 409 803588 68960 89755490
Chills 39.32 10.15 881 803116 131100 89693350
Hyperlipidaemia 39.16 10.15 91 803906 22825 89801625
Motor dysfunction 39.14 10.15 69 803928 19161 89805289
Atrioventricular block complete 39.12 10.15 19 803978 9792 89814658
Muscle twitching 39.07 10.15 99 803898 24103 89800347
Hypothyroidism 39.05 10.15 293 803704 52834 89771616
Anti-cyclic citrullinated peptide antibody 38.92 10.15 391 803606 26830 89797620
Vaginal flatulence 38.76 10.15 33 803964 12605 89811845
Lupus-like syndrome 38.74 10.15 629 803368 48217 89776233
Asphyxia 38.50 10.15 8 803989 7095 89817355
Lethargy 38.41 10.15 366 803631 62773 89761677
Irritability 38.36 10.15 174 803823 35488 89788962
Small for dates baby 37.87 10.15 114 803883 4893 89819557
Eosinophilia 37.86 10.15 128 803869 28405 89796045
Coagulopathy 37.80 10.15 95 803902 23194 89801256
Sinus tachycardia 37.77 10.15 128 803869 28385 89796065
Acute myeloid leukaemia 37.70 10.15 79 803918 20561 89803889
Proctitis 37.61 10.15 48 803949 15211 89809239
Drug dose omission by device 37.59 10.15 22 803975 10209 89814241
X-ray abnormal 37.55 10.15 589 803408 44835 89779615
Lymphocyte count decreased 37.11 10.15 172 803825 34878 89789572
Gastrointestinal haemorrhage 37.00 10.15 570 803427 89678 89734772
Paradoxical drug reaction 36.96 10.15 4 803993 5762 89818688
Graft versus host disease 36.95 10.15 13 803984 8131 89816319
Tumour lysis syndrome 36.87 10.15 27 803970 11125 89813325
Deep vein thrombosis 36.77 10.15 581 803416 91039 89733411
Sensory loss 36.66 10.15 65 803932 18010 89806440
Neck deformity 36.64 10.15 68 803929 2121 89822329
Pain in extremity 36.56 10.15 4548 799449 445981 89378469
Cardiogenic shock 36.55 10.15 104 803893 24364 89800086
Dyspnoea exertional 36.32 10.15 438 803559 71850 89752600
Blood pressure diastolic decreased 36.29 10.15 381 803616 26445 89798005
Cerebral infarction 36.19 10.15 118 803879 26478 89797972
Aspergillus infection 36.05 10.15 26 803971 10797 89813653
Oedema 35.83 10.15 2145 801852 198150 89626300
Pulmonary arterial hypertension 35.76 10.15 116 803881 26071 89798379
Abdominal pain 35.70 10.15 3023 800974 392698 89431752
Laryngitis 35.69 10.15 641 803356 50112 89774338
Melaena 35.53 10.15 173 803824 34624 89789826
Myoclonus 35.32 10.15 73 803924 19095 89805355
Nodule 35.16 10.15 377 803620 26309 89798141
Disability 35.09 10.15 532 803465 40213 89784237
Diabetes mellitus 34.57 10.15 388 803609 64487 89759963
Acute graft versus host disease 34.53 10.15 4 803993 5464 89818986
Tinnitus 34.47 10.15 232 803765 42870 89781580
Hypoaesthesia 34.27 10.15 3235 800762 310975 89513475
Joint dislocation 34.21 10.15 571 803426 44011 89780439
Paralysis 33.96 10.15 31 803966 11447 89813003
Female genital tract fistula 33.82 10.15 67 803930 17801 89806649
Device use error 33.68 10.15 11 803986 7210 89817240
Stevens-Johnson syndrome 33.62 10.15 140 803857 29236 89795214
Nightmare 33.45 10.15 91 803906 21634 89802816
Onychomycosis 33.35 10.15 491 803506 36885 89787565
Gangrene 33.32 10.15 39 803958 12837 89811613
Epistaxis 33.10 10.15 543 803454 84582 89739868
Fall 32.95 10.15 3756 800241 478054 89346396
Hypomagnesaemia 32.93 10.15 183 803814 35405 89789045
Hospitalisation 32.73 10.15 875 803122 127225 89697225
Tuberculosis 32.72 10.15 207 803790 12342 89812108
Mucosal inflammation 32.57 10.15 340 803657 57285 89767165
Asthma-chronic obstructive pulmonary disease overlap syndrome 32.44 10.15 3 803994 4896 89819554
International normalised ratio increased 32.43 10.15 266 803731 47050 89777400
Pseudomonas infection 32.43 10.15 51 803946 14814 89809636
Myocarditis 32.43 10.15 45 803952 13761 89810689
Exostosis 32.21 10.15 656 803341 52478 89771972
Device related infection 31.99 10.15 119 803878 25667 89798783
Rebound effect 31.97 10.15 22 803975 9362 89815088
Erythema multiforme 31.79 10.15 37 803960 12209 89812241
Tardive dyskinesia 31.77 10.15 30 803967 10900 89813550
Epstein-Barr virus infection 31.74 10.15 27 803970 10317 89814133
Onychomadesis 31.66 10.15 579 803418 45419 89779031
Substance abuse 31.66 10.15 5 803992 5401 89819049
Wheelchair user 31.62 10.15 145 803852 7640 89816810
Dysuria 31.55 10.15 212 803785 39189 89785261
Lymphopenia 31.49 10.15 101 803896 22780 89801670
Maternal drugs affecting foetus 31.41 10.15 109 803888 5046 89819404
Lupus vulgaris 31.30 10.15 568 803429 44491 89779959
Haemorrhage intracranial 31.23 10.15 54 803943 15108 89809342
Product preparation error 31.22 10.15 27 803970 10234 89814216
Panic attack 31.21 10.15 124 803873 26241 89798209
Drug hypersensitivity 31.19 10.15 3618 800379 459991 89364459
Complication of device insertion 31.10 10.15 28 803969 10408 89814042
Haemoptysis 31.01 10.15 171 803826 33149 89791301
Multiple fractures 30.95 10.15 167 803830 9395 89815055
Hepatic cirrhosis 30.51 10.15 756 803241 62497 89761953
Interstitial lung disease 30.50 10.15 485 803512 75920 89748530
Rheumatoid nodule 30.46 10.15 293 803704 19873 89804577
Radiculopathy 30.42 10.15 75 803922 18430 89806020
Ischaemic stroke 30.40 10.15 98 803899 22068 89802382
Febrile bone marrow aplasia 30.39 10.15 25 803972 9713 89814737
Hallucination, visual 30.36 10.15 104 803893 22988 89801462
Pyrexia 30.27 10.15 5276 798721 655209 89169241
Acute respiratory distress syndrome 30.23 10.15 141 803856 28545 89795905
Genital haemorrhage 30.19 10.15 20 803977 8682 89815768
Infective pulmonary exacerbation of cystic fibrosis 30.13 10.15 28 803969 10251 89814199
Complication of device removal 30.12 10.15 9 803988 6246 89818204
Haematochezia 30.05 10.15 445 803552 70468 89753982
Maternal exposure before pregnancy 29.89 10.15 186 803811 11027 89813423
Lip swelling 29.80 10.15 210 803787 38400 89786050
Glycosylated haemoglobin increased 29.76 10.15 58 803939 15504 89808946
Hot flush 29.68 10.15 361 803636 59127 89765323
Vaginal discharge 29.61 10.15 82 803915 19382 89805068
Multiple-drug resistance 29.61 10.15 16 803981 7760 89816690
Skin burning sensation 29.56 10.15 83 803914 19528 89804922
Clostridium difficile colitis 29.51 10.15 129 803868 26577 89797873
Mental disorder 29.46 10.15 167 803830 32151 89792299
Muscle rigidity 29.44 10.15 51 803946 14258 89810192
Heart rate decreased 29.34 10.15 651 803346 52854 89771596
Tenderness 29.33 10.15 366 803631 26502 89797948
Inappropriate schedule of product administration 29.32 10.15 1061 802936 148872 89675578
Ventricular septal defect 29.27 10.15 110 803887 5297 89819153
Hepatic cytolysis 29.14 10.15 158 803839 30758 89793692
Product administration error 28.97 10.15 128 803869 26295 89798155
Sleep apnoea syndrome 28.96 10.15 164 803833 31583 89792867
Acute graft versus host disease in skin 28.77 10.15 4 803993 4752 89819698
Jaundice cholestatic 28.69 10.15 28 803969 10015 89814435
Retinitis 28.57 10.15 490 803507 37968 89786482
Device dislocation 28.52 10.15 163 803834 31319 89793131
Urinary retention 28.30 10.15 207 803790 37537 89786913
Lung disorder 28.30 10.15 1613 802384 148270 89676180
Neuroleptic malignant syndrome 28.24 10.15 57 803940 15039 89809411
Accidental overdose 28.04 10.15 142 803855 28131 89796319
Infusion site pain 27.96 10.15 86 803911 19652 89804798
Cardiomyopathy 27.94 10.15 89 803908 20117 89804333
Influenza like illness 27.89 10.15 525 803472 80086 89744364
Pulmonary hypertension 27.82 10.15 242 803755 42281 89782169
Nervousness 27.39 10.15 183 803814 33873 89790577
Swelling face 27.18 10.15 533 803464 80819 89743631
Eye irritation 27.11 10.15 183 803814 33795 89790655
Crying 27.06 10.15 126 803871 25519 89798931
Psychomotor hyperactivity 26.97 10.15 45 803952 12768 89811682
Cytomegalovirus infection reactivation 26.96 10.15 18 803979 7782 89816668
Premature rupture of membranes 26.78 10.15 109 803888 5449 89819001
Pericardial effusion 26.66 10.15 204 803793 36629 89787821
Respiratory acidosis 26.40 10.15 20 803977 8099 89816351
Body temperature decreased 26.25 10.15 325 803672 23491 89800959
Blood urea increased 26.21 10.15 160 803837 30253 89794197
Myopathy 26.19 10.15 50 803947 13468 89810982
Smear cervix abnormal 26.13 10.15 74 803923 3068 89821382
Blood pressure diastolic increased 26.06 10.15 200 803797 12706 89811744
Anuria 26.00 10.15 58 803939 14760 89809690
Blood glucose decreased 25.99 10.15 113 803884 23316 89801134
Pemphigoid 25.97 10.15 25 803972 9001 89815449
Circulatory collapse 25.90 10.15 123 803874 24781 89799669
Cardiotoxicity 25.88 10.15 38 803959 11351 89813099
Urinary incontinence 25.83 10.15 211 803786 37355 89787095
Purpura 25.80 10.15 58 803939 14720 89809730
Sinus disorder 25.79 10.15 189 803808 34258 89790192
Bradyphrenia 25.73 10.15 18 803979 7594 89816856
Product administered to patient of inappropriate age 25.73 10.15 5 803992 4648 89819802
Product prescribing issue 25.51 10.15 20 803977 7959 89816491
Rash maculo-papular 25.44 10.15 236 803761 40697 89783753
Oral candidiasis 25.37 10.15 197 803800 35258 89789192
Incorrect dose administered 25.21 10.15 521 803476 78409 89746041
Vascular device infection 25.14 10.15 42 803955 11910 89812540
Ileus 24.96 10.15 70 803927 16476 89807974
Acute chest syndrome 24.91 10.15 40 803957 1108 89823342
Dysmorphism 24.89 10.15 64 803933 2504 89821946
Sexual dysfunction 24.86 10.15 6 803991 4798 89819652
Labelled drug-drug interaction medication error 24.84 10.15 58 803939 14524 89809926
Leukocytosis 24.68 10.15 167 803830 30823 89793627
Latent tuberculosis 24.66 10.15 70 803927 2906 89821544
Sinus bradycardia 24.63 10.15 73 803924 16879 89807571
Colitis microscopic 24.61 10.15 38 803959 11121 89813329
Limb deformity 24.61 10.15 87 803910 4065 89820385
Pulmonary congestion 24.56 10.15 89 803908 19344 89805106
Heart rate increased 24.14 10.15 790 803207 112112 89712338
Blood potassium decreased 24.05 10.15 289 803708 47438 89777012
Electrocardiogram QRS complex prolonged 24.02 10.15 18 803979 7330 89817120
Lymphoedema 24.00 10.15 54 803943 13699 89810751
Aspiration 23.96 10.15 66 803931 15627 89808823
Eosinophil count increased 23.95 10.15 50 803947 13031 89811419
Drug effective for unapproved indication 23.89 10.15 21 803976 7897 89816553
Dissociation 23.89 10.15 15 803982 6700 89817750
Enthesopathy 23.83 10.15 154 803843 9250 89815200
Device breakage 23.81 10.15 56 803941 13988 89810462
Transaminases increased 23.74 10.15 213 803784 36979 89787471
Product prescribing error 23.73 10.15 163 803834 29982 89794468
Schizoaffective disorder 23.73 10.15 8 803989 5139 89819311
Graft versus host disease in gastrointestinal tract 23.67 10.15 5 803992 4383 89820067
Multiple allergies 23.65 10.15 63 803934 15083 89809367
Prescribed overdose 23.63 10.15 1076 802921 96549 89727901
Mucormycosis 23.62 10.15 3 803994 3818 89820632
Ketoacidosis 23.62 10.15 10 803987 5585 89818865
Oliguria 23.60 10.15 36 803961 10588 89813862
Haematoma 23.47 10.15 227 803770 38821 89785629
Dysphonia 23.35 10.15 406 803591 62678 89761772
Pulmonary alveolar haemorrhage 23.34 10.15 12 803985 5986 89818464
Complication associated with device 23.33 10.15 91 803906 19358 89805092
Subarachnoid haemorrhage 23.29 10.15 81 803916 17823 89806627
Seronegative arthritis 23.29 10.15 256 803741 17978 89806472
Atrial tachycardia 23.28 10.15 12 803985 5978 89818472
Breast cancer female 23.18 10.15 62 803935 14824 89809626
Cytomegalovirus viraemia 23.03 10.15 20 803977 7566 89816884
Middle insomnia 23.01 10.15 74 803923 16677 89807773
Ankylosing spondylitis 22.99 10.15 197 803800 12936 89811514
Agranulocytosis 22.98 10.15 199 803798 34803 89789647
Skin toxicity 22.96 10.15 16 803981 6763 89817687
Right ventricular failure 22.94 10.15 90 803907 19115 89805335
Metastases to lymph nodes 22.85 10.15 43 803954 11646 89812804
Atrial septal defect 22.84 10.15 138 803859 8096 89816354
Ear infection 22.71 10.15 794 803203 68981 89755469
Bacteraemia 22.69 10.15 111 803886 22189 89802261
Mood altered 22.68 10.15 77 803920 17067 89807383
Malignant mediastinal neoplasm 22.65 10.15 43 803954 1365 89823085
Therapeutic response shortened 22.64 10.15 115 803882 22764 89801686
Acute myocardial infarction 22.63 10.15 199 803798 34691 89789759
Systemic inflammatory response syndrome 22.57 10.15 15 803982 6501 89817949
Hyperuricaemia 22.57 10.15 16 803981 6703 89817747
Tubulointerstitial nephritis 22.54 10.15 132 803865 25211 89799239
Fear 22.44 10.15 74 803923 16548 89807902
Rales 22.39 10.15 69 803928 15758 89808692
Maternal exposure timing unspecified 22.33 10.15 301 803696 22182 89802268
Pulseless electrical activity 22.11 10.15 28 803969 8904 89815546
Breast cancer metastatic 22.10 10.15 65 803932 15067 89809383
Hypophagia 21.99 10.15 208 803789 35729 89788721
Respiration abnormal 21.84 10.15 23 803974 7940 89816510
Chronic graft versus host disease 21.75 10.15 5 803992 4134 89820316
Presyncope 21.70 10.15 179 803818 31626 89792824
Adenovirus infection 21.63 10.15 7 803990 4615 89819835
Wheezing 21.62 10.15 2421 801576 235659 89588791
Rotator cuff repair 21.59 10.15 59 803938 2395 89822055
Cyanosis 21.48 10.15 94 803903 19361 89805089
Paranoia 21.46 10.15 52 803945 12856 89811594
Transplant dysfunction 21.41 10.15 10 803987 5272 89819178
Antinuclear antibody positive 21.41 10.15 148 803849 9093 89815357
Developmental hip dysplasia 21.41 10.15 45 803952 1540 89822910
Delusion 21.29 10.15 58 803939 13782 89810668
Respiratory tract congestion 21.19 10.15 149 803848 27261 89797189
Blepharospasm 21.16 10.15 643 803354 54802 89769648
Total lung capacity increased 21.15 10.15 9 803988 5012 89819438
Head injury 21.07 10.15 176 803821 31012 89793438
Asthma 21.05 10.15 1855 802142 240305 89584145
Rheumatoid lung 21.00 10.15 82 803915 4021 89820429
Jaundice 20.85 10.15 186 803811 32331 89792119
Synovial disorder 20.83 10.15 68 803929 3050 89821400
Bone marrow failure 20.80 10.15 184 803813 32037 89792413
Hypervolaemia 20.73 10.15 188 803809 32569 89791881
Immune reconstitution inflammatory syndrome 20.72 10.15 19 803978 7000 89817450
Finger deformity 20.55 10.15 408 803589 32489 89791961
Pathogen resistance 20.55 10.15 25 803972 8090 89816360
Sleep terror 20.47 10.15 7 803990 4457 89819993
Generalised oedema 20.47 10.15 93 803904 18960 89805490
Glomerular filtration rate decreased 20.45 10.15 79 803918 16853 89807597
Atrioventricular block 20.44 10.15 29 803968 8786 89815664
Sneezing 20.43 10.15 168 803829 29701 89794749
Drug tolerance 20.40 10.15 246 803751 17670 89806780
Blood lactic acid increased 20.23 10.15 29 803968 8749 89815701
Renal tubular necrosis 20.21 10.15 64 803933 14491 89809959
Bradypnoea 20.19 10.15 8 803989 4650 89819800
Gastroenteritis viral 20.16 10.15 380 803617 29975 89794475
Body height below normal 19.96 10.15 53 803944 2115 89822335
Pallor 19.95 10.15 200 803797 33965 89790485
Device issue 19.81 10.15 167 803830 29370 89795080
Hallucinations, mixed 19.81 10.15 14 803983 5875 89818575
Toxic encephalopathy 19.79 10.15 29 803968 8670 89815780
Blood test abnormal 19.79 10.15 107 803890 20845 89803605
Multiple sclerosis 19.77 10.15 155 803842 27685 89796765
Placental disorder 19.77 10.15 44 803953 1567 89822883
Infusion site erythema 19.77 10.15 59 803938 13611 89810839
Affective disorder 19.74 10.15 24 803973 7769 89816681
Renal injury 19.74 10.15 38 803959 10205 89814245
Chronic obstructive pulmonary disease 19.46 10.15 502 803495 73327 89751123
Tenosynovitis stenosans 19.42 10.15 78 803919 3875 89820575
Synovial fluid analysis 19.31 10.15 62 803935 2756 89821694
Blindness 19.30 10.15 147 803850 26421 89798029
Acute coronary syndrome 19.24 10.15 42 803955 10771 89813679
Systemic candida 19.18 10.15 10 803987 4949 89819501
Nail operation 18.99 10.15 48 803949 1858 89822592
Product adhesion issue 18.97 10.15 11 803986 5131 89819319
Localised infection 18.92 10.15 410 803587 33152 89791298
Hepatitis acute 18.79 10.15 43 803954 10844 89813606
Anti-neutrophil cytoplasmic antibody positive vasculitis 18.77 10.15 6 803991 3987 89820463
Injection site erythema 18.77 10.15 1061 802936 97441 89727009
Hepatitis B reactivation 18.63 10.15 6 803991 3968 89820482
Neck mass 18.60 10.15 76 803921 3806 89820644
Anosmia 18.58 10.15 37 803960 9811 89814639
Treatment noncompliance 18.48 10.15 335 803662 51392 89773058
Device leakage 18.45 10.15 38 803959 9953 89814497
Urinary tract infection 18.42 10.15 2402 801595 303230 89521220
Red blood cell sedimentation rate 18.36 10.15 86 803911 4572 89819878
Coronary artery disease 18.34 10.15 200 803797 33423 89791027
Shock haemorrhagic 18.32 10.15 52 803945 12193 89812257
Stillbirth 18.32 10.15 121 803876 7322 89817128
Klebsiella infection 18.32 10.15 40 803957 10257 89814193
Bundle branch block right 18.29 10.15 13 803984 5440 89819010
Product storage error 18.23 10.15 105 803892 20136 89804314
Bundle branch block left 18.22 10.15 26 803971 7859 89816591
Bradykinesia 18.18 10.15 20 803977 6768 89817682
Salivary hypersecretion 18.17 10.15 33 803964 9059 89815391
Hyperprolactinaemia 18.16 10.15 13 803984 5420 89819030
Abdominal distension 18.11 10.15 960 803037 129641 89694809
Foetal anticonvulsant syndrome 18.11 10.15 26 803971 651 89823799
Loose body in joint 18.01 10.15 39 803958 1363 89823087
Product administration interrupted 18.00 10.15 54 803943 12438 89812012
Pulmonary haemorrhage 17.95 10.15 27 803970 7986 89816464
Pruritus genital 17.91 10.15 9 803988 4549 89819901
Electrolyte imbalance 17.91 10.15 130 803867 23615 89800835
Injection site pruritus 17.87 10.15 614 803383 53220 89771230
Polyuria 17.86 10.15 39 803958 10001 89814449
Dementia 17.82 10.15 131 803866 23730 89800720
Body temperature increased 17.78 10.15 284 803713 44426 89780024
Rhinovirus infection 17.77 10.15 16 803981 5947 89818503
Therapy interrupted 17.75 10.15 325 803672 49783 89774667
Hallucination, auditory 17.75 10.15 77 803920 15898 89808552
Lacrimation increased 17.70 10.15 154 803843 26908 89797542
Acidosis 17.68 10.15 56 803941 12680 89811770
Pseudomonal sepsis 17.67 10.15 8 803989 4294 89820156
Enterocolitis 17.65 10.15 42 803955 10448 89814002
Spinal stenosis 17.61 10.15 234 803763 17190 89807260
Product dose omission in error 17.60 10.15 108 803889 20395 89804055
Subdural haematoma 17.43 10.15 82 803915 16563 89807887
Postoperative wound infection 17.38 10.15 189 803808 13237 89811213
Plasma cell myeloma 17.37 10.15 256 803741 40572 89783878
Post-traumatic stress disorder 17.33 10.15 21 803976 6807 89817643
Cleft lip and palate 17.31 10.15 27 803970 729 89823721
Walking aid user 17.31 10.15 425 803572 35081 89789369
Visual acuity reduced 17.26 10.15 129 803868 23281 89801169
End stage renal disease 17.22 10.15 31 803966 8540 89815910
Blood lactate dehydrogenase increased 17.22 10.15 147 803850 25785 89798665
Femur fracture 17.21 10.15 533 803464 45549 89778901
Bone lesion 17.20 10.15 19 803978 6418 89818032
Liver disorder 17.08 10.15 1273 802724 119996 89704454
Personality change 17.06 10.15 24 803973 7297 89817153
Night sweats 17.03 10.15 1345 802652 127421 89697029
Hypoglycaemic coma 16.99 10.15 3 803994 2987 89821463
Hereditary angioedema 16.98 10.15 36 803961 9329 89815121
Hypogammaglobulinaemia 16.97 10.15 44 803953 10630 89813820
Pre-eclampsia 16.92 10.15 161 803836 10887 89813563
Hyperthermia 16.90 10.15 42 803955 10293 89814157
Tumour marker increased 16.81 10.15 16 803981 5791 89818659
Diplopia 16.81 10.15 168 803829 28546 89795904
Arthritis infective 16.78 10.15 125 803872 7867 89816583
Confusional state 16.78 10.15 3770 800227 382435 89442015
Throat tightness 16.64 10.15 174 803823 29310 89795140
Diabetes insipidus 16.64 10.15 4 803993 3208 89821242
Cholelithiasis 16.64 10.15 347 803650 52159 89772291
Temperature intolerance 16.63 10.15 53 803944 11977 89812473
Catheter site pain 16.59 10.15 15 803982 5564 89818886
Immune effector cell-associated neurotoxicity syndrome 16.57 10.15 16 803981 5752 89818698
Ankle arthroplasty 16.51 10.15 59 803938 2772 89821678
Progressive multifocal leukoencephalopathy 16.47 10.15 77 803920 15578 89808872
Pneumatosis intestinalis 16.45 10.15 5 803992 3432 89821018
Amyloid arthropathy 16.42 10.15 42 803955 1638 89822812
Synovial cyst 16.41 10.15 168 803829 11584 89812866
Nail disorder 16.30 10.15 660 803337 58407 89766043
Cardiac disorder 16.27 10.15 382 803615 56490 89767960
Generalised tonic-clonic seizure 16.22 10.15 215 803782 34688 89789762
Maternal exposure during delivery 16.03 10.15 7 803990 3839 89820611
Skin plaque 15.95 10.15 41 803956 9934 89814516
Blood pressure inadequately controlled 15.95 10.15 19 803978 6205 89818245
Infusion site pruritus 15.94 10.15 22 803975 6743 89817707
Sleep disorder due to a general medical condition 15.90 10.15 290 803707 44448 89780002
Renal disorder 15.89 10.15 238 803759 37621 89786829
Ventricular extrasystoles 15.89 10.15 62 803935 13188 89811262
Congenital arterial malformation 15.79 10.15 17 803980 314 89824136
Human antichimeric antibody positive 15.78 10.15 43 803954 1743 89822707
Therapy non-responder 15.72 10.15 1413 802584 135291 89689159
Feeding disorder 15.69 10.15 91 803906 17421 89807029
Staphylococcal infection 15.68 10.15 319 803678 48120 89776330
Laryngospasm 15.68 10.15 5 803992 3328 89821122
Septic shock 15.68 10.15 599 803398 83561 89740889
Dermatitis acneiform 15.65 10.15 20 803977 6334 89818116
Acute pulmonary oedema 15.61 10.15 39 803958 9541 89814909
Vasoplegia syndrome 15.61 10.15 3 803994 2811 89821639
Hyperbilirubinaemia 15.59 10.15 67 803930 13869 89810581
Scleritis 15.55 10.15 89 803908 5119 89819331
Thrombosis 15.55 10.15 513 803484 72738 89751712
Unevaluable event 15.52 10.15 369 803628 54479 89769971
Antibody test positive 15.51 10.15 60 803937 2929 89821521
Cardiac failure acute 15.50 10.15 54 803943 11875 89812575
Spondylitis 15.42 10.15 193 803804 13985 89810465
Facial paralysis 15.42 10.15 78 803919 15456 89808994
Product substitution issue 15.38 10.15 95 803902 17913 89806537
Anhedonia 15.36 10.15 51 803946 11380 89813070
Malignant melanoma 15.35 10.15 175 803822 12401 89812049
Insurance issue 15.34 10.15 48 803949 10910 89813540
Device physical property issue 15.31 10.15 3 803994 2773 89821677
Tenosynovitis 15.29 10.15 197 803800 14370 89810080
Polyhydramnios 15.25 10.15 53 803944 2455 89821995
Lung opacity 15.24 10.15 19 803978 6083 89818367
Sputum discoloured 15.20 10.15 112 803885 20279 89804171
Limb reduction defect 15.18 10.15 23 803974 605 89823845
Dermatitis exfoliative 15.17 10.15 16 803981 5520 89818930
Hypoalbuminaemia 15.12 10.15 81 803916 15816 89808634
Hypophosphataemia 15.08 10.15 74 803923 14780 89809670
Pharyngeal swelling 15.05 10.15 42 803955 9902 89814548
Trigeminal neuralgia 15.01 10.15 9 803988 4122 89820328
Reversible cerebral vasoconstriction syndrome 15.00 10.15 9 803988 4121 89820329
Bezoar 14.99 10.15 3 803994 2731 89821719
Inflammatory marker increased 14.98 10.15 136 803861 9078 89815372
Extra dose administered 14.95 10.15 37 803960 9081 89815369
Clear cell renal cell carcinoma 14.93 10.15 39 803958 1541 89822909
Hyperthyroidism 14.92 10.15 98 803899 18212 89806238
Nasal obstruction 14.86 10.15 54 803943 2558 89821892
Malaise 14.83 10.15 4812 799185 581174 89243276
Potentiating drug interaction 14.81 10.15 17 803980 5645 89818805
Euglycaemic diabetic ketoacidosis 14.78 10.15 20 803977 6181 89818269
Lymphatic fistula 14.77 10.15 37 803960 1424 89823026
Troponin increased 14.76 10.15 64 803933 13217 89811233
Amylase increased 14.74 10.15 25 803972 7047 89817403
Varicella zoster virus infection 14.73 10.15 8 803989 3869 89820581
Dyspepsia 14.72 10.15 1990 802007 196170 89628280
Hypertelorism 14.71 10.15 21 803976 523 89823927
Impaired gastric emptying 14.69 10.15 61 803936 12748 89811702
Haemodynamic instability 14.68 10.15 54 803943 11685 89812765
Infusion site swelling 14.60 10.15 54 803943 11666 89812784
Exercise tolerance decreased 14.56 10.15 28 803969 7523 89816927
Haematuria 14.54 10.15 220 803777 34717 89789733
Kidney transplant rejection 14.51 10.15 13 803984 4844 89819606
Epstein-Barr virus associated lymphoproliferative disorder 14.47 10.15 3 803994 2664 89821786
Neutrophilia 14.42 10.15 18 803979 5760 89818690
Nasal oedema 14.41 10.15 104 803893 6480 89817970
Device malfunction 14.34 10.15 118 803879 20859 89803591
Pneumonia viral 14.31 10.15 36 803961 8787 89815663
Neuralgia 14.29 10.15 195 803802 31305 89793145
Abortion incomplete 14.27 10.15 5 803992 3135 89821315
Intracranial pressure increased 14.26 10.15 24 803973 6787 89817663
Activated partial thromboplastin time prolonged 14.25 10.15 30 803967 7795 89816655
Breast feeding 14.25 10.15 27 803970 856 89823594
Type 1 diabetes mellitus 14.23 10.15 13 803984 4799 89819651
Speech disorder developmental 14.19 10.15 28 803969 915 89823535
Pain of skin 14.18 10.15 84 803913 15998 89808452
Skin papilloma 14.15 10.15 92 803905 5538 89818912
Retrognathia 14.13 10.15 21 803976 543 89823907
Femoral hernia incarcerated 14.02 10.15 37 803960 1471 89822979
Pneumonia bacterial 14.00 10.15 62 803935 12728 89811722
Pneumonitis 13.97 10.15 292 803705 43878 89780572
Hypernatraemia 13.95 10.15 40 803957 9347 89815103
Hyperpyrexia 13.92 10.15 13 803984 4748 89819702
Mouth ulceration 13.79 10.15 458 803539 39516 89784934
Hepatitis fulminant 13.78 10.15 9 803988 3936 89820514
Immune thrombocytopenia 13.75 10.15 66 803931 13260 89811190
Hypoventilation 13.75 10.15 16 803981 5280 89819170
Impaired quality of life 13.72 10.15 135 803862 23009 89801441
Nocardiosis 13.72 10.15 3 803994 2567 89821883
Hyperlactacidaemia 13.69 10.15 10 803987 4126 89820324
Bone density increased 13.69 10.15 27 803970 882 89823568
Device use issue 13.62 10.15 8 803989 3705 89820745
Ileus paralytic 13.60 10.15 15 803982 5070 89819380
Nephropathy toxic 13.59 10.15 62 803935 12626 89811824
Fracture delayed union 13.58 10.15 51 803946 2455 89821995
Pregnancy with contraceptive device 13.48 10.15 15 803982 5051 89819399
Neoplasm recurrence 13.48 10.15 6 803991 3253 89821197
Endophthalmitis 13.45 10.15 13 803984 4672 89819778
Product residue present 13.41 10.15 11 803986 4280 89820170
Eosinophilic granulomatosis with polyangiitis 13.41 10.15 3 803994 2527 89821923
Wound infection pseudomonas 13.41 10.15 44 803953 1979 89822471
Peripheral sensory neuropathy 13.32 10.15 40 803957 9210 89815240
Candida infection 13.32 10.15 217 803780 33840 89790610
Blood phosphorus decreased 13.29 10.15 15 803982 5019 89819431
Crohn's disease 13.26 10.15 81 803916 4770 89819680
Loss of employment 13.16 10.15 5 803992 2982 89821468
Toxic epidermal necrolysis 13.14 10.15 206 803791 32322 89792128
Haemorrhage in pregnancy 13.14 10.15 46 803951 2139 89822311
Atrial flutter 13.12 10.15 50 803947 10708 89813742
Cholecystitis chronic 13.09 10.15 44 803953 9782 89814668
Full blood count abnormal 13.08 10.15 237 803760 36360 89788090
Iritis 13.05 10.15 66 803931 3620 89820830
Polydipsia 13.03 10.15 11 803986 4220 89820230
Central nervous system lesion 13.02 10.15 56 803941 11590 89812860
Pneumothorax 13.02 10.15 108 803889 19059 89805391
Brain injury 13.00 10.15 31 803966 7707 89816743
Cystitis haemorrhagic 12.92 10.15 18 803979 5495 89818955
Uterine perforation 12.90 10.15 30 803967 7524 89816926
Short stature 12.88 10.15 29 803968 1041 89823409
Rectal haemorrhage 12.87 10.15 601 803396 82143 89742307
Myocardial ischaemia 12.80 10.15 71 803926 13743 89810707
Disturbance in social behaviour 12.77 10.15 11 803986 4177 89820273
Breast cancer stage II 12.75 10.15 407 803590 34927 89789523
Amenorrhoea 12.72 10.15 57 803940 11665 89812785
Hypercapnia 12.67 10.15 25 803972 6652 89817798
Gastroschisis 12.59 10.15 17 803980 401 89824049
Exomphalos 12.58 10.15 20 803977 549 89823901
Eyelid oedema 12.57 10.15 56 803941 11478 89812972
Osteolysis 12.53 10.15 8 803989 3542 89820908
Ulcer haemorrhage 12.51 10.15 314 803683 26007 89798443
Metastasis 12.51 10.15 22 803975 6115 89818335
Haematemesis 12.50 10.15 217 803780 33509 89790941
Catheter site erythema 12.48 10.15 15 803982 4879 89819571
Intervertebral disc degeneration 12.44 10.15 219 803778 17055 89807395
Nail injury 12.38 10.15 24 803973 774 89823676
International normalised ratio fluctuation 12.32 10.15 6 803991 3087 89821363
Immunosuppressant drug level increased 12.30 10.15 14 803983 4666 89819784
Cyst 12.30 10.15 211 803786 16350 89808100
Eye swelling 12.24 10.15 185 803812 29201 89795249
Cross sensitivity reaction 12.23 10.15 5 803992 2852 89821598
HIV-associated neurocognitive disorder 12.23 10.15 10 803987 128 89824322
Back injury 12.20 10.15 518 803479 46104 89778346
Erythema of eyelid 12.15 10.15 7 803990 3276 89821174
Restless legs syndrome 12.12 10.15 134 803863 22336 89802114
Lipase increased 12.08 10.15 54 803943 11057 89813393
Congenital anomaly 12.07 10.15 97 803900 6250 89818200
Osteonecrosis 12.06 10.15 162 803835 26079 89798371
Pancreatic steatosis 12.06 10.15 37 803960 1605 89822845
Atrioventricular block second degree 12.05 10.15 13 803984 4439 89820011
Pulmonary toxicity 11.96 10.15 57 803940 11474 89812976
Terminal state 11.95 10.15 5 803992 2813 89821637
Epidermal necrosis 11.93 10.15 47 803950 2314 89822136
Long QT syndrome 11.83 10.15 11 803986 4026 89820424
Carotid artery occlusion 11.82 10.15 24 803973 6318 89818132
Hypokinesia 11.81 10.15 86 803911 15611 89808839
Blood loss anaemia 11.81 10.15 48 803949 10092 89814358
Heparin-induced thrombocytopenia 11.80 10.15 18 803979 5294 89819156
Blood sodium decreased 11.80 10.15 173 803824 27440 89797010
Hypertransaminasaemia 11.76 10.15 87 803910 15738 89808712
Cardiac failure chronic 11.73 10.15 20 803977 5626 89818824
Increased appetite 11.72 10.15 59 803938 11706 89812744
Skin ulcer 11.70 10.15 550 803447 49525 89774925
Immune-mediated enterocolitis 11.69 10.15 15 803982 4742 89819708
Needle issue 11.65 10.15 74 803923 13860 89810590
Persecutory delusion 11.64 10.15 7 803990 3201 89821249
Hepatitis cholestatic 11.64 10.15 38 803959 8523 89815927
Choking 11.61 10.15 61 803936 11972 89812478
Fracture 11.60 10.15 267 803730 21809 89802641
Benign ovarian tumour 11.57 10.15 18 803979 485 89823965
Pulmonary tuberculosis 11.55 10.15 78 803919 4756 89819694
Device deployment issue 11.53 10.15 16 803981 4893 89819557
Total lung capacity decreased 11.53 10.15 10 803987 3785 89820665
Cushingoid 11.52 10.15 142 803855 10253 89814197
Sensitisation 11.51 10.15 12 803985 4163 89820287
Respiratory disorder 11.49 10.15 464 803533 64352 89760098
Abnormal dreams 11.47 10.15 56 803941 11201 89813249
Feeling hot 11.46 10.15 570 803427 77438 89747012
Ingrown hair 11.44 10.15 20 803977 595 89823855
Subacute cutaneous lupus erythematosus 11.42 10.15 9 803988 3573 89820877
Bacterial infection 11.42 10.15 143 803854 23301 89801149
Product availability issue 11.41 10.15 31 803966 7373 89817077
Device occlusion 11.41 10.15 43 803954 9239 89815211
Type I hypersensitivity 11.39 10.15 12 803985 4143 89820307
Metastases to peritoneum 11.39 10.15 12 803985 4143 89820307
Pulmonary function test abnormal 11.39 10.15 5 803992 2734 89821716
Micturition urgency 11.38 10.15 56 803941 11177 89813273
Congenital cerebral cyst 11.35 10.15 13 803984 258 89824192
Adverse drug reaction 11.32 10.15 1192 802805 115509 89708941
Drug screen positive 11.29 10.15 10 803987 3747 89820703
Oral pain 11.26 10.15 213 803784 32470 89791980
Oligoarthritis 11.26 10.15 19 803978 549 89823901
Foetal distress syndrome 11.22 10.15 37 803960 1668 89822782
Metastases to spine 11.21 10.15 10 803987 3733 89820717
Productive cough 11.15 10.15 564 803433 76499 89747951
Paranasal sinus discomfort 11.15 10.15 24 803973 6186 89818264
Cerebral haematoma 11.09 10.15 13 803984 4276 89820174
Pathological fracture 11.08 10.15 46 803951 9614 89814836
Dermatitis 11.02 10.15 135 803862 22085 89802365
Ventricular hypokinesia 11.02 10.15 19 803978 5322 89819128
Lip oedema 11.02 10.15 15 803982 4624 89819826
Immunisation 11.00 10.15 3 803994 2210 89822240
Metabolic disorder 10.97 10.15 32 803965 7438 89817012
Colorectal cancer 10.95 10.15 11 803986 3882 89820568
Cleft palate 10.95 10.15 31 803966 1285 89823165
Incoherent 10.93 10.15 17 803980 4960 89819490
Product physical issue 10.91 10.15 21 803976 5639 89818811
Pancreatitis 10.90 10.15 507 803490 69319 89755131
Alcoholic liver disease 10.89 10.15 9 803988 117 89824333
Lung transplant 10.89 10.15 10 803987 3682 89820768
Skin fissures 10.87 10.15 125 803872 20684 89803766
Body mass index decreased 10.87 10.15 18 803979 512 89823938
Injection site warmth 10.87 10.15 217 803780 17298 89807152
Sickle cell anaemia 10.82 10.15 20 803977 622 89823828
Human anti-human antibody test 10.81 10.15 16 803981 412 89824038
Learning disorder 10.80 10.15 24 803973 854 89823596
Catheter site haemorrhage 10.74 10.15 10 803987 3658 89820792
Ageusia 10.73 10.15 91 803906 15985 89808465
Depressive symptom 10.72 10.15 19 803978 5266 89819184
Flatulence 10.71 10.15 282 803715 41085 89783365
Intraocular pressure increased 10.70 10.15 30 803967 7063 89817387
Cervical incompetence 10.68 10.15 20 803977 628 89823822
Cell death 10.63 10.15 7 803990 3048 89821402
Blood calcium increased 10.62 10.15 63 803934 11995 89812455
Nystagmus 10.59 10.15 31 803966 7196 89817254
Retinal haemorrhage 10.58 10.15 22 803975 5742 89818708
Staphylococcal sepsis 10.56 10.15 45 803952 9338 89815112
Cyst rupture 10.54 10.15 23 803974 808 89823642
Joint lock 10.52 10.15 48 803949 2524 89821926
Joint warmth 10.51 10.15 37 803960 1725 89822725
Implant site pain 10.51 10.15 5 803992 2607 89821843
Tendonitis 10.47 10.15 256 803741 21116 89803334
Dermatitis contact 10.46 10.15 74 803923 13521 89810929
Laryngeal oedema 10.46 10.15 29 803968 6852 89817598
Clostridium test positive 10.44 10.15 20 803977 5381 89819069
Hypotonia 10.44 10.15 59 803938 11367 89813083
Bronchial secretion retention 10.42 10.15 10 803987 3605 89820845
Pneumonia fungal 10.42 10.15 30 803967 7001 89817449
Inadequate analgesia 10.41 10.15 8 803989 3216 89821234
Upper-airway cough syndrome 10.41 10.15 85 803912 15050 89809400
Incontinence 10.40 10.15 73 803924 13362 89811088
Skin weeping 10.32 10.15 6 803991 2794 89821656
Neutrophil count increased 10.31 10.15 116 803881 19274 89805176
Ventricular arrhythmia 10.23 10.15 14 803983 4307 89820143
Decreased appetite 10.23 10.15 3083 800914 373457 89450993
Lymph gland infection 10.21 10.15 18 803979 539 89823911

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Rheumatoid arthritis 593.49 10.19 937 235577 41503 42343318
Drug abuse 355.40 10.19 74 236440 104697 42280124
Foetal exposure during pregnancy 304.52 10.19 754 235760 46557 42338264
Completed suicide 274.74 10.19 96 236418 96369 42288452
Toxicity to various agents 271.06 10.19 539 235975 228597 42156224
Psoriatic arthropathy 242.90 10.19 470 236044 24497 42360324
Arthralgia 226.10 10.19 1926 234588 203312 42181509
Psoriasis 154.52 10.19 606 235908 47998 42336823
Drug interaction 154.09 10.19 861 235653 266138 42118683
Sickle cell anaemia with crisis 142.27 10.19 155 236359 4735 42380086
Joint swelling 131.87 10.19 734 235780 67288 42317533
Dysmorphism 131.00 10.19 124 236390 3192 42381629
Product use in unapproved indication 105.10 10.19 597 235917 183859 42200962
Intentional overdose 103.84 10.19 80 236434 51376 42333445
Pain 101.22 10.19 1914 234600 242934 42141887
Musculoskeletal stiffness 97.48 10.19 601 235913 57164 42327657
Arthritis 96.73 10.19 476 236038 41589 42343232
Off label use 96.63 10.19 2753 233761 635582 41749239
Hepatic function abnormal 90.98 10.19 91 236423 51476 42333345
Blood pressure fluctuation 90.82 10.19 342 236172 26566 42358255
Synovitis 89.64 10.19 238 236276 15329 42369492
Disease progression 88.40 10.19 453 236061 143203 42241618
Blood pressure systolic increased 87.48 10.19 347 236167 27621 42357200
Enthesopathy 86.74 10.19 120 236394 4708 42380113
Death 84.46 10.19 1982 234532 469203 41915618
Premature baby 83.80 10.19 301 236213 22852 42361969
Small for dates baby 83.08 10.19 123 236391 5140 42379681
Drug resistance 77.43 10.19 47 236467 34201 42350620
Exposure during pregnancy 77.18 10.19 156 236358 8392 42376429
Tenosynovitis 73.07 10.19 109 236405 4586 42380235
Arthropathy 70.97 10.19 339 236175 29258 42355563
Intentional product misuse 70.97 10.19 148 236366 61752 42323069
Blood pressure systolic abnormal 70.32 10.19 117 236397 5411 42379410
C-reactive protein abnormal 68.64 10.19 156 236358 9105 42375716
Drug dependence 67.08 10.19 39 236475 29055 42355766
Speech disorder developmental 65.73 10.19 72 236442 2213 42382608
Drug ineffective 64.64 10.19 2851 233663 627346 41757475
Coma 63.99 10.19 125 236389 53429 42331392
Multiple organ dysfunction syndrome 63.69 10.19 299 236215 96736 42288085
Acute kidney injury 62.71 10.19 1556 234958 365781 42019040
Neonatal respiratory distress syndrome 62.13 10.19 99 236415 4414 42380407
Maternal exposure during pregnancy 60.23 10.19 125 236389 6853 42377968
Febrile neutropenia 60.03 10.19 700 235814 185003 42199818
Foetal anticonvulsant syndrome 59.42 10.19 51 236463 1151 42383670
Blood pressure diastolic abnormal 57.92 10.19 114 236400 6014 42378807
Rhabdomyolysis 57.55 10.19 230 236284 77789 42307032
Appendicolith 56.16 10.19 5 236509 13451 42371370
Weight decreased 53.86 10.19 1523 234991 206425 42178396
Osteoarthritis 53.85 10.19 273 236241 24132 42360689
Low birth weight baby 53.11 10.19 148 236366 9807 42375014
Alanine aminotransferase abnormal 52.95 10.19 97 236417 4847 42379974
Hypoglycaemia neonatal 52.11 10.19 62 236452 2088 42382733
Heart rate decreased 51.83 10.19 364 236150 36168 42348653
Suicide attempt 51.35 10.19 112 236402 45988 42338833
Poisoning 50.59 10.19 10 236504 14689 42370132
Maternal drugs affecting foetus 49.84 10.19 82 236432 3757 42381064
Myelosuppression 49.59 10.19 93 236421 40368 42344453
Hypospadias 48.77 10.19 78 236436 3489 42381332
Learning disorder 48.57 10.19 44 236470 1069 42383752
Overdose 48.55 10.19 363 236151 104901 42279920
No adverse event 47.55 10.19 90 236424 38931 42345890
Cryptorchism 46.76 10.19 57 236457 1970 42382851
Atrial septal defect 46.53 10.19 122 236392 7797 42377024
Haemoglobin decreased 46.45 10.19 1011 235503 131460 42253361
Peripheral swelling 45.95 10.19 730 235784 89540 42295281
Blood pressure diastolic decreased 44.69 10.19 143 236371 10232 42374589
Autism spectrum disorder 44.55 10.19 68 236446 2920 42381901
Pancytopenia 43.67 10.19 906 235608 116837 42267984
Malignant neoplasm progression 43.50 10.19 388 236126 108012 42276809
Joint effusion 43.33 10.19 99 236415 5798 42379023
Rheumatoid nodule 43.03 10.19 67 236447 2928 42381893
Colitis ulcerative 42.67 10.19 270 236244 25905 42358916
Pain in extremity 42.64 10.19 1116 235398 149488 42235333
Drug ineffective for unapproved indication 42.24 10.19 124 236390 46039 42338782
Jaundice neonatal 41.93 10.19 56 236458 2123 42382698
Lower respiratory tract infection 41.72 10.19 380 236134 40826 42343995
Pathogen resistance 41.11 10.19 7 236507 11443 42373378
Cytomegalovirus infection 40.71 10.19 73 236441 32233 42352588
Body temperature decreased 40.47 10.19 173 236341 14240 42370581
Blood pressure diastolic increased 40.04 10.19 101 236413 6304 42378517
Haematochezia 39.56 10.19 497 236017 57939 42326882
Cardiac failure 39.23 10.19 391 236123 106465 42278356
Grip strength decreased 39.19 10.19 71 236443 3517 42381304
Sedation 39.18 10.19 68 236446 30407 42354414
Renal impairment 38.96 10.19 407 236107 109821 42275000
Syndactyly 38.79 10.19 36 236478 903 42383918
C-reactive protein increased 38.61 10.19 530 235984 63030 42321791
Ventricular septal defect 38.20 10.19 79 236435 4320 42380501
Ventricular fibrillation 38.02 10.19 68 236446 30055 42354766
Maternal exposure during breast feeding 37.95 10.19 45 236469 1510 42383311
Altered state of consciousness 37.88 10.19 65 236449 29194 42355627
Palmar-plantar erythrodysaesthesia syndrome 37.83 10.19 35 236479 20547 42364274
Nasopharyngitis 37.16 10.19 664 235850 83332 42301489
Tongue disorder 36.96 10.19 88 236426 5295 42379526
Poisoning deliberate 36.81 10.19 6 236508 10128 42374693
Inflammation 35.74 10.19 315 236199 33532 42351289
Hand deformity 35.50 10.19 70 236444 3698 42381123
Neck pain 34.68 10.19 285 236229 29729 42355092
Sopor 34.48 10.19 15 236499 13187 42371634
Sleep disorder due to a general medical condition 34.11 10.19 28 236486 17425 42367396
Joint laxity 33.99 10.19 24 236490 402 42384419
Foot deformity 33.88 10.19 82 236432 4986 42379835
Acute hepatic failure 33.86 10.19 27 236487 17046 42367775
Exposure via breast milk 33.64 10.19 54 236460 2423 42382398
Drug use disorder 33.59 10.19 8 236506 10325 42374496
Respiratory arrest 33.38 10.19 67 236447 28357 42356464
Knee arthroplasty 33.35 10.19 116 236398 8665 42376156
Aspergillus infection 32.74 10.19 24 236490 15813 42369008
Therapy partial responder 32.34 10.19 38 236476 19983 42364838
Cardiogenic shock 31.69 10.19 97 236417 35543 42349278
Appendicitis 31.33 10.19 41 236473 20572 42364249
Bradycardia neonatal 31.24 10.19 38 236476 1310 42383511
Abdominal discomfort 31.22 10.19 589 235925 74666 42310155
Immune reconstitution inflammatory syndrome 30.79 10.19 9 236505 10134 42374687
Substance abuse 30.77 10.19 6 236508 8899 42375922
Foetal growth restriction 30.64 10.19 81 236433 5202 42379619
Shock 30.61 10.19 73 236441 29048 42355773
Cytomegalovirus infection reactivation 30.32 10.19 12 236502 11166 42373655
Infusion related reaction 29.90 10.19 489 236025 60317 42324504
Developmental delay 29.84 10.19 59 236455 3123 42381698
Post transplant lymphoproliferative disorder 29.77 10.19 7 236507 9113 42375708
Acute chest syndrome 29.67 10.19 33 236481 1032 42383789
Cardiac murmur 29.66 10.19 145 236369 12630 42372191
Respiratory disorder neonatal 29.61 10.19 45 236469 1925 42382896
Wrong technique in product usage process 29.37 10.19 129 236385 42506 42342315
Polyarthritis 29.35 10.19 78 236436 5026 42379795
Red blood cell sedimentation rate increased 29.33 10.19 121 236393 9803 42375018
Anal fissure 29.05 10.19 79 236435 5160 42379661
Blood pressure increased 29.03 10.19 756 235758 101172 42283649
Angioedema 28.98 10.19 129 236385 42348 42342473
Suicidal ideation 28.94 10.19 153 236361 48008 42336813
Dysgraphia 28.86 10.19 51 236463 2477 42382344
Tendonitis 28.74 10.19 120 236394 9774 42375047
Caesarean section 28.72 10.19 46 236468 2060 42382761
Plagiocephaly 28.66 10.19 25 236489 577 42384244
Depressed level of consciousness 28.49 10.19 153 236361 47817 42337004
Fall 28.45 10.19 1582 234932 232938 42151883
Finger deformity 28.42 10.19 40 236474 1595 42383226
Wound 28.17 10.19 177 236337 16940 42367881
BK virus infection 28.16 10.19 7 236507 8777 42376044
Hypermobility syndrome 27.92 10.19 20 236494 343 42384478
Serotonin syndrome 27.79 10.19 64 236450 25781 42359040
Drug withdrawal syndrome neonatal 27.52 10.19 70 236444 4391 42380430
Mucocutaneous ulceration 27.51 10.19 23 236491 500 42384321
Catarrh 27.15 10.19 84 236430 5902 42378919
Bradycardia 26.89 10.19 324 236190 85160 42299661
Congenital hand malformation 26.88 10.19 25 236489 629 42384192
Neurotoxicity 26.72 10.19 57 236457 23594 42361227
Talipes 26.68 10.19 46 236468 2190 42382631
Hypoglycaemia 26.36 10.19 209 236305 59645 42325176
Basal cell carcinoma 26.33 10.19 216 236298 22517 42362304
Anaphylactic shock 26.30 10.19 57 236457 23460 42361361
Haematocrit decreased 26.29 10.19 303 236211 34605 42350216
Large for dates baby 26.22 10.19 29 236485 901 42383920
Mobility decreased 25.94 10.19 305 236209 35001 42349820
Renal failure 25.46 10.19 605 235909 143121 42241700
Venoocclusive liver disease 24.92 10.19 13 236501 10289 42374532
Agitation neonatal 24.92 10.19 35 236479 1393 42383428
Tuberculosis 24.44 10.19 116 236398 9983 42374838
Cytokine release syndrome 24.29 10.19 146 236368 44381 42340440
Mucormycosis 24.29 10.19 5 236509 7138 42377683
Diaphragmatic disorder 24.09 10.19 32 236482 1207 42383614
Suspected suicide 24.08 10.19 3 236511 6196 42378625
Joint range of motion decreased 24.08 10.19 96 236418 7657 42377164
Ultrasound antenatal screen 24.03 10.19 22 236492 542 42384279
Acute graft versus host disease 23.67 10.19 8 236506 8207 42376614
Burns second degree 23.56 10.19 81 236433 6015 42378806
Hydrops foetalis 23.44 10.19 27 236487 878 42383943
Blood phosphorus increased 23.38 10.19 21 236493 12504 42372317
Language disorder 23.34 10.19 46 236468 2429 42382392
Ankylosing spondylitis 23.24 10.19 89 236425 6967 42377854
Neuroleptic malignant syndrome 23.23 10.19 53 236461 21419 42363402
Somnolence 23.09 10.19 601 235913 140504 42244317
Psychotic disorder 22.88 10.19 84 236430 29124 42355697
Foetal disorder 22.74 10.19 29 236485 1050 42383771
Trisomy 18 22.73 10.19 26 236488 839 42383982
Akathisia 22.71 10.19 15 236499 10436 42374385
Adenovirus infection 22.67 10.19 5 236509 6804 42378017
Drug withdrawal syndrome 22.66 10.19 54 236460 21495 42363326
Vitamin B6 deficiency 22.39 10.19 17 236497 320 42384501
Musculoskeletal pain 22.32 10.19 283 236231 33057 42351764
Astigmatism 22.30 10.19 32 236482 1299 42383522
Serum ferritin increased 22.11 10.19 89 236425 7130 42377691
Selective eating disorder 21.99 10.19 37 236477 1727 42383094
Frequent bowel movements 21.96 10.19 198 236316 21209 42363612
Syringe issue 21.91 10.19 10 236504 8546 42376275
Arthritis infective 21.86 10.19 61 236453 4045 42380776
Lactic acidosis 21.85 10.19 154 236360 45107 42339714
Systemic lupus erythematosus 21.77 10.19 106 236408 9218 42375603
Skin cancer 21.73 10.19 123 236391 11339 42373482
Incorrect route of product administration 21.71 10.19 66 236448 24239 42360582
Hyperglycaemia 21.67 10.19 157 236357 45702 42339119
Knee deformity 21.46 10.19 24 236490 755 42384066
Strabismus 21.37 10.19 43 236471 2305 42382516
Cystitis haemorrhagic 21.36 10.19 7 236507 7322 42377499
Dyspraxia 21.24 10.19 19 236495 454 42384367
Maternal exposure before pregnancy 21.22 10.19 28 236486 1049 42383772
Polyomavirus-associated nephropathy 21.14 10.19 3 236511 5612 42379209
Hyperbilirubinaemia neonatal 21.08 10.19 25 236489 839 42383982
Nasal disorder 20.99 10.19 39 236475 1970 42382851
Anal fistula 20.98 10.19 79 236435 6134 42378687
Encephalitis toxic 20.71 10.19 15 236499 262 42384559
Localised infection 20.68 10.19 188 236326 20185 42364636
Parosmia 20.59 10.19 91 236423 7600 42377221
Vitamin D deficiency 20.47 10.19 94 236420 7979 42376842
Pruritus 20.42 10.19 848 235666 187923 42196898
Intervertebral disc degeneration 20.35 10.19 88 236426 7279 42377542
Radiation inflammation 20.27 10.19 27 236487 1021 42383800
Drug dose omission by device 20.27 10.19 4 236510 5882 42378939
Joint stiffness 20.02 10.19 127 236387 12195 42372626
Cytomegalovirus viraemia 19.85 10.19 17 236497 10360 42374461
Fatigue 19.84 10.19 2732 233782 432909 41951912
Osteonecrosis of jaw 19.82 10.19 48 236466 19001 42365820
Motor developmental delay 19.75 10.19 22 236492 689 42384132
Arthrodesis 19.73 10.19 20 236494 561 42384260
Therapeutic product effect decreased 19.67 10.19 316 236198 38834 42345987
Hypotonia neonatal 19.67 10.19 32 236482 1452 42383369
Crohn's disease 19.65 10.19 48 236466 2936 42381885
Intellectual disability 19.62 10.19 37 236477 1890 42382931
Temperature regulation disorder 19.62 10.19 28 236486 1131 42383690
Cleft lip and palate 19.56 10.19 25 236489 907 42383914
Aptyalism 19.47 10.19 17 236497 393 42384428
Neck mass 19.44 10.19 36 236478 1814 42383007
Drug reaction with eosinophilia and systemic symptoms 19.43 10.19 145 236369 41930 42342891
Thymus disorder 19.11 10.19 14 236500 249 42384572
Pulmonary alveolar haemorrhage 19.10 10.19 33 236481 14783 42370038
Back pain 19.10 10.19 966 235548 140810 42244011
Lung neoplasm malignant 19.09 10.19 176 236338 18971 42365850
Alcohol poisoning 19.06 10.19 88 236426 7486 42377335
Umbilical hernia 19.01 10.19 70 236444 5377 42379444
Dyslexia 18.98 10.19 16 236498 352 42384469
Hepatic steatosis 18.85 10.19 192 236322 21256 42363565
Proteinuria 18.73 10.19 65 236449 22918 42361903
Gingival pain 18.72 10.19 95 236419 8399 42376422
Vitamin B12 deficiency 18.67 10.19 65 236449 4857 42379964
Ankyloglossia congenital 18.61 10.19 16 236498 362 42384459
Cardiotoxicity 18.60 10.19 9 236505 7436 42377385
Acute graft versus host disease in skin 18.51 10.19 9 236505 7415 42377406
Electrocardiogram T wave alternans 18.49 10.19 10 236504 101 42384720
Congenital foot malformation 18.46 10.19 17 236497 422 42384399
Cleft lip 18.46 10.19 15 236499 313 42384508
Transient aphasia 18.41 10.19 20 236494 609 42384212
Colorectal cancer 18.26 10.19 3 236511 5035 42379786
Central nervous system mass 18.14 10.19 23 236491 828 42383993
Neoplasm progression 18.06 10.19 91 236423 28909 42355912
Wall motion score index abnormal 18.05 10.19 23 236491 832 42383989
Asphyxia 18.03 10.19 12 236502 8314 42376507
Posterior reversible encephalopathy syndrome 17.99 10.19 27 236487 12794 42372027
Urticaria 17.83 10.19 296 236218 73740 42311081
Intentional self-injury 17.71 10.19 36 236478 15166 42369655
Hypertriglyceridaemia 17.70 10.19 18 236496 10108 42374713
Haemolysis 17.59 10.19 102 236412 9487 42375334
Dysstasia 17.49 10.19 136 236378 13950 42370871
Congenital anomaly 17.48 10.19 31 236483 1510 42383311
Post procedural infection 17.46 10.19 71 236443 5714 42379107
Cardiac septal defect 17.45 10.19 24 236490 936 42383885
Sexual dysfunction 17.22 10.19 8 236506 6767 42378054
Tachycardia 17.21 10.19 428 236086 100659 42284162
Chronic graft versus host disease 17.13 10.19 6 236508 6019 42378802
Airway remodelling 17.12 10.19 23 236491 877 42383944
Ear disorder 17.12 10.19 36 236478 1992 42382829
Disseminated intravascular coagulation 17.09 10.19 75 236439 24719 42360102
Nephropathy toxic 17.07 10.19 43 236471 16795 42368026
Drug intolerance 17.03 10.19 575 235939 79849 42304972
Spina bifida 17.03 10.19 16 236498 408 42384413
Cellulitis 17.01 10.19 455 236059 61130 42323691
Medical device implantation 16.88 10.19 19 236495 602 42384219
Spinal disorder 16.88 10.19 60 236454 4531 42380290
Steroid dependence 16.84 10.19 78 236436 6644 42378177
Pulmonary fibrosis 16.82 10.19 224 236290 26457 42358364
Head discomfort 16.80 10.19 65 236449 5112 42379709
Transfusion-related circulatory overload 16.73 10.19 21 236493 748 42384073
Multiple congenital abnormalities 16.73 10.19 18 236496 542 42384279
Red blood cell sedimentation rate 16.70 10.19 25 236489 1055 42383766
Malignant melanoma 16.60 10.19 99 236415 9301 42375520
Hypertransaminasaemia 16.59 10.19 16 236498 9211 42375610
Myasthenia gravis 16.52 10.19 41 236473 16096 42368725
Oxygen saturation decreased 16.48 10.19 473 236041 64214 42320607
Vomiting 16.45 10.19 1384 235130 288339 42096482
Renal aplasia 16.43 10.19 21 236493 762 42384059
Respiratory depression 16.31 10.19 52 236462 18816 42366005
Limb reduction defect 16.24 10.19 14 236500 318 42384503
Fistula discharge 16.22 10.19 25 236489 1083 42383738
Pyrexia 16.21 10.19 1927 234587 392115 41992706
Lacrimal disorder 16.16 10.19 14 236500 320 42384501
Cytomegalovirus chorioretinitis 16.16 10.19 3 236511 4608 42380213
Arthritis bacterial 16.14 10.19 70 236444 5798 42379023
Headache 16.13 10.19 1540 234974 237829 42146992
Device leakage 16.10 10.19 20 236494 10265 42374556
Congenital bladder anomaly 16.09 10.19 13 236501 269 42384552
Blood albumin decreased 16.08 10.19 143 236371 15259 42369562
Blood parathyroid hormone decreased 16.06 10.19 31 236483 1612 42383209
Exposure to toxic agent 16.02 10.19 4 236510 5000 42379821
Synovial cyst 15.96 10.19 41 236473 2588 42382233
Influenza 15.94 10.19 455 236059 61720 42323101
Weight decrease neonatal 15.91 10.19 14 236500 327 42384494
Hypopnoea 15.89 10.19 86 236428 7796 42377025
Migraine 15.87 10.19 213 236301 25201 42359620
Decreased gait velocity 15.80 10.19 11 236503 180 42384641
Atopy 15.70 10.19 23 236491 952 42383869
Pectus excavatum 15.62 10.19 12 236502 230 42384591
Squamous cell carcinoma of lung 15.62 10.19 37 236477 2219 42382602
Joint ankylosis 15.61 10.19 31 236483 1646 42383175
Obsessive-compulsive disorder 15.60 10.19 9 236505 6734 42378087
Thrombotic microangiopathy 15.58 10.19 37 236477 14745 42370076
Haematotoxicity 15.54 10.19 23 236491 10962 42373859
Haemangioma congenital 15.53 10.19 17 236497 522 42384299
Rebound effect 15.49 10.19 11 236503 7368 42377453
Hepatic failure 15.43 10.19 136 236378 37964 42346857
Constipation 15.31 10.19 740 235774 161551 42223270
Endophthalmitis 15.29 10.19 3 236511 4430 42380391
Hypertelorism 15.25 10.19 18 236496 601 42384220
Cardiac arrest 15.24 10.19 476 236038 108844 42275977
Loss of personal independence in daily activities 15.21 10.19 373 236141 49443 42335378
Otitis media 15.17 10.19 50 236464 3633 42381188
Back disorder 15.16 10.19 82 236432 7432 42377389
Cholelithiasis 15.13 10.19 197 236317 23149 42361672
Granuloma skin 15.12 10.19 25 236489 1150 42383671
Anti-cyclic citrullinated peptide antibody positive 15.06 10.19 33 236481 1879 42382942
Vitamin D decreased 14.91 10.19 57 236457 4458 42380363
Erythrosis 14.90 10.19 9 236505 114 42384707
Skin injury 14.82 10.19 40 236474 2601 42382220
Disease recurrence 14.81 10.19 100 236414 29578 42355243
Upper respiratory tract infection 14.80 10.19 322 236192 41851 42342970
Glycosylated haemoglobin increased 14.72 10.19 31 236483 12893 42371928
Nephrotic syndrome 14.68 10.19 16 236498 8702 42376119
Hypokalaemia 14.68 10.19 295 236219 71426 42313395
Lung opacity 14.67 10.19 7 236507 5830 42378991
Ear infection 14.48 10.19 121 236393 12683 42372138
Potentiating drug interaction 14.44 10.19 9 236505 6459 42378362
Aggression 14.42 10.19 166 236348 43997 42340824
Respiratory rate increased 14.41 10.19 108 236406 10954 42373867
Hydrocele 14.37 10.19 39 236475 2544 42382277
Agranulocytosis 14.37 10.19 105 236409 30507 42354314
Failure to anastomose 14.36 10.19 11 236503 210 42384611
Red blood cell sedimentation rate decreased 14.27 10.19 12 236502 263 42384558
Heart rate irregular 14.26 10.19 144 236370 15906 42368915
Red blood cell count decreased 14.23 10.19 258 236256 32457 42352364
Lower respiratory tract congestion 14.21 10.19 29 236485 1571 42383250
PCO2 decreased 14.17 10.19 31 236483 1763 42383058
Patent ductus arteriosus 14.15 10.19 47 236467 3429 42381392
Cerebral haemorrhage 14.11 10.19 143 236371 38823 42345998
Septic arthritis staphylococcal 14.07 10.19 16 236498 513 42384308
Respiratory failure 13.97 10.19 575 235939 127557 42257264
Spondyloarthropathy 13.91 10.19 21 236493 893 42383928
Abortion spontaneous 13.89 10.19 14 236500 390 42384431
Bursitis 13.88 10.19 70 236444 6174 42378647
Neutropenia neonatal 13.81 10.19 21 236493 899 42383922
Oesophageal fibrosis 13.74 10.19 10 236504 176 42384645
Carcinoid tumour of the small bowel 13.74 10.19 14 236500 395 42384426
Immunosuppression 13.65 10.19 87 236427 8366 42376455
Bone cyst 13.58 10.19 29 236485 1622 42383199
Hepatic cirrhosis 13.51 10.19 168 236346 19534 42365287
Tooth malformation 13.50 10.19 10 236504 181 42384640
Disability assessment scale score increased 13.49 10.19 14 236500 404 42384417
Hernia pain 13.47 10.19 12 236502 285 42384536
Hypophosphataemia 13.46 10.19 65 236449 20880 42363941
Rhinitis 13.44 10.19 113 236401 11864 42372957
End stage renal disease 13.38 10.19 47 236467 16511 42368310
Pulmonary pain 13.30 10.19 28 236486 1550 42383271
Anaemia vitamin B12 deficiency 13.26 10.19 16 236498 547 42384274
Bronchopulmonary aspergillosis 13.25 10.19 59 236455 19370 42365451
Microangiopathy 13.21 10.19 29 236485 1653 42383168
Gastrointestinal infection 13.21 10.19 73 236441 6670 42378151
Communication disorder 13.15 10.19 40 236474 2785 42382036
Red blood cell sedimentation rate abnormal 13.14 10.19 49 236465 3787 42381034
Diverticulum 13.05 10.19 79 236435 7462 42377359
Agitation 13.02 10.19 265 236249 64049 42320772
Skin ulcer 13.00 10.19 207 236307 25394 42359427
Weight increased 12.98 10.19 728 235786 107255 42277566
Infection 12.98 10.19 753 235761 111315 42273506
Polydactyly 12.95 10.19 24 236490 1210 42383611
Alcoholic liver disease 12.94 10.19 16 236498 561 42384260
Juvenile idiopathic arthritis 12.88 10.19 38 236476 2601 42382220
Low set ears 12.87 10.19 15 236499 494 42384327
Acute respiratory distress syndrome 12.85 10.19 106 236408 30002 42354819
Cerebral haemorrhage neonatal 12.83 10.19 12 236502 304 42384517
Brain oedema 12.76 10.19 47 236467 16280 42368541
Exposure via skin contact 12.72 10.19 6 236508 5032 42379789
Accidental exposure to product 12.69 10.19 64 236450 20329 42364492
Disinhibition 12.69 10.19 3 236511 3892 42380929
C-reactive protein decreased 12.68 10.19 34 236480 2202 42382619
Cirrhosis alcoholic 12.67 10.19 19 236495 803 42384018
Sinusitis 12.66 10.19 348 236166 46944 42337877
Autoscopy 12.64 10.19 11 236503 253 42384568
Attention deficit hyperactivity disorder 12.63 10.19 42 236472 3066 42381755
Withdrawal syndrome 12.58 10.19 41 236473 14734 42370087
Complications of transplanted kidney 12.58 10.19 7 236507 5343 42379478
Hepatitis E antibody positive 12.53 10.19 11 236503 256 42384565
Alcohol withdrawal syndrome 12.53 10.19 26 236488 1425 42383396
Arnold-Chiari malformation 12.53 10.19 13 236501 375 42384446
Abdominal adhesions 12.53 10.19 29 236485 1713 42383108
Blister infected 12.52 10.19 15 236499 509 42384312
Ventricular tachycardia 12.51 10.19 107 236407 30053 42354768
Dry throat 12.50 10.19 40 236474 2862 42381959
Depressive symptom 12.49 10.19 3 236511 3850 42380971
Maternal exposure timing unspecified 12.47 10.19 13 236501 377 42384444
Gangrene neonatal 12.45 10.19 10 236504 205 42384616
Loss of consciousness 12.42 10.19 404 236110 91950 42292871
Cystitis bacterial 12.41 10.19 10 236504 206 42384615
Hepatitis fulminant 12.38 10.19 6 236508 4953 42379868
Blood potassium decreased 12.38 10.19 170 236344 20214 42364607
Foetal distress syndrome 12.36 10.19 23 236491 1163 42383658
Psychiatric decompensation 12.36 10.19 4 236510 4218 42380603
Neutropenia 12.33 10.19 946 235568 198485 42186336
Injection site haemorrhage 12.27 10.19 109 236405 11627 42373194
Liver function test abnormal 12.24 10.19 250 236264 32141 42352680
Microcephaly 12.19 10.19 20 236494 914 42383907
Tinnitus 12.17 10.19 227 236287 28711 42356110
Hip arthroplasty 12.16 10.19 60 236454 5245 42379576
Contusion 12.11 10.19 312 236202 41673 42343148
Respiratory tract infection viral 12.08 10.19 44 236470 3362 42381459
Transplant rejection 12.06 10.19 37 236477 13551 42371270
Haemodynamic instability 12.02 10.19 33 236481 12524 42372297
Oropharyngeal pain 12.00 10.19 315 236199 42195 42342626
Asthma 11.96 10.19 259 236255 62055 42322766
Skin abrasion 11.91 10.19 82 236432 8093 42376728
Nocardiosis 11.90 10.19 7 236507 5183 42379638
Bronchiolitis 11.84 10.19 48 236466 3858 42380963
Electrocardiogram QRS complex prolonged 11.81 10.19 9 236505 5814 42379007
Kidney infection 11.76 10.19 71 236443 6699 42378122
Second primary malignancy 11.74 10.19 22 236492 9553 42375268
Psychomotor retardation 11.74 10.19 52 236462 4347 42380474
Sarcopenia 11.73 10.19 19 236495 859 42383962
Multiple-drug resistance 11.72 10.19 14 236500 7308 42377513
Developmental coordination disorder 11.71 10.19 10 236504 224 42384597
Nail bed inflammation 11.70 10.19 9 236505 173 42384648
Anal atresia 11.69 10.19 11 236503 281 42384540
Anti-erythropoietin antibody positive 11.67 10.19 19 236495 863 42383958
Peritoneal dialysis complication 11.64 10.19 30 236484 1897 42382924
Graft versus host disease 11.62 10.19 35 236479 12890 42371931
Asymptomatic bacteriuria 11.57 10.19 10 236504 228 42384593
Myoclonus 11.53 10.19 52 236462 17013 42367808
Diverticular perforation 11.53 10.19 46 236468 3670 42381151
Fibula fracture 11.53 10.19 22 236492 1134 42383687
Hypoxia 11.46 10.19 297 236217 69489 42315332
Infective pulmonary exacerbation of cystic fibrosis 11.43 10.19 16 236498 7802 42377019
Reactive gastropathy 11.41 10.19 15 236499 560 42384261
Emphysema 11.40 10.19 108 236406 11727 42373094
Vascular insufficiency 11.38 10.19 12 236502 353 42384468
Educational problem 11.35 10.19 15 236499 563 42384258
Foetal heart rate deceleration abnormality 11.33 10.19 15 236499 564 42384257
Progressive multifocal leukoencephalopathy 11.28 10.19 30 236484 11506 42373315
Blood insulin increased 11.27 10.19 12 236502 357 42384464
Hepatitis 11.25 10.19 97 236417 27203 42357618
Gross motor delay 11.21 10.19 12 236502 359 42384462
Product quality issue 11.20 10.19 56 236458 17826 42366995
Hepatitis E virus test positive 11.19 10.19 11 236503 297 42384524
Euglycaemic diabetic ketoacidosis 11.16 10.19 9 236505 5651 42379170
Eosinophilic myocarditis 11.16 10.19 24 236490 1349 42383472
Abnormal loss of weight 11.15 10.19 56 236458 4931 42379890
Pleural fibrosis 11.15 10.19 24 236490 1350 42383471
Immunodeficiency 11.15 10.19 74 236440 7216 42377605
Rectal haemorrhage 11.10 10.19 357 236157 49249 42335572
Interstitial lung disease 11.09 10.19 341 236173 78121 42306700
Ligament rupture 11.07 10.19 24 236490 1356 42383465
Haemangioma 11.07 10.19 30 236484 1955 42382866
Cerebral infarction 11.03 10.19 115 236399 31054 42353767
Hypermetropia 11.00 10.19 14 236500 506 42384315
Vein disorder 10.97 10.19 31 236483 2071 42382750
Cardiac failure chronic 10.96 10.19 23 236491 9578 42375243
Lung cancer metastatic 10.95 10.19 39 236475 2947 42381874
Palindromic rheumatism 10.95 10.19 9 236505 191 42384630
Glomerular filtration rate decreased 10.94 10.19 50 236464 16301 42368520
Abnormal behaviour 10.90 10.19 94 236420 26357 42358464
Oliguria 10.89 10.19 22 236492 9291 42375530
Eosinophil count decreased 10.88 10.19 44 236470 3532 42381289
Drug level increased 10.84 10.19 93 236421 26107 42358714
Blood folate increased 10.84 10.19 11 236503 309 42384512
Hypocalcaemia 10.81 10.19 111 236403 30062 42354759
Scoliosis 10.77 10.19 40 236474 3086 42381735
Nail bed bleeding 10.76 10.19 13 236501 445 42384376
Graft versus host disease in skin 10.64 10.19 8 236506 5204 42379617
Hyperthermia 10.63 10.19 35 236479 12539 42372282
Peripheral artery thrombosis 10.57 10.19 36 236478 2661 42382160
Fever neonatal 10.56 10.19 8 236506 150 42384671
Inguinal hernia 10.49 10.19 85 236429 8827 42375994
Tinea pedis 10.49 10.19 30 236484 2018 42382803
Tender joint count decreased 10.48 10.19 10 236504 260 42384561
Swollen joint count decreased 10.48 10.19 10 236504 260 42384561
Scarlet fever 10.46 10.19 7 236507 107 42384714
Dissociation 10.43 10.19 4 236510 3794 42381027
Protein deficiency 10.42 10.19 10 236504 262 42384559
Stress ulcer 10.36 10.19 10 236504 264 42384557
Skin graft failure 10.34 10.19 8 236506 155 42384666
Anal spasm 10.34 10.19 8 236506 155 42384666
Congenital hydronephrosis 10.31 10.19 17 236497 780 42384041
Melaena 10.30 10.19 152 236362 38594 42346227
Myalgia 10.29 10.19 432 236082 95648 42289173
Nerve compression 10.29 10.19 47 236467 3981 42380840
Rheumatoid vasculitis 10.26 10.19 10 236504 267 42384554
Congenital genital malformation 10.26 10.19 8 236506 157 42384664
Mucosal ulceration 10.25 10.19 23 236491 1331 42383490
Bone erosion 10.24 10.19 50 236464 4353 42380468

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Completed suicide 1215.54 10.03 178 823006 242203 109523912
Systemic lupus erythematosus 1105.35 10.03 4277 818907 250061 109516054
Toxicity to various agents 1097.48 10.03 1175 822009 479380 109286735
Arthropathy 1053.64 10.03 4587 818597 282935 109483180
Pemphigus 1031.92 10.03 3728 819456 210842 109555273
Synovitis 1015.19 10.03 4387 818797 269705 109496410
Hand deformity 996.71 10.03 3732 819452 214774 109551341
Joint swelling 944.41 10.03 6082 817102 436763 109329352
Glossodynia 922.09 10.03 3681 819503 218323 109547792
Anti-cyclic citrullinated peptide antibody positive 799.80 10.03 3072 820112 178912 109587203
Wound 794.45 10.03 3655 819529 230782 109535333
Drug abuse 790.68 10.03 176 823008 177235 109588880
Rheumatoid arthritis 785.08 10.03 4344 818840 295269 109470846
Pericarditis 752.72 10.03 3430 819754 215684 109550431
Maternal exposure during pregnancy 698.26 10.03 3741 819443 251142 109514973
Duodenal ulcer perforation 678.88 10.03 2872 820312 174828 109591287
Abdominal discomfort 663.22 10.03 5109 818075 388749 109377366
Arthralgia 655.35 10.03 8759 814425 770873 108995242
Drug interaction 642.32 10.03 1766 821418 498417 109267698
Helicobacter infection 637.92 10.03 2865 820319 179012 109587103
Infusion related reaction 637.68 10.03 4937 818247 376225 109389890
Swelling 625.51 10.03 4615 818569 346426 109419689
Alopecia 605.41 10.03 4716 818468 360037 109406078
Psoriatic arthropathy 566.92 10.03 2929 820255 193832 109572283
Therapeutic product effect decreased 562.69 10.03 3424 819760 240892 109525223
Discomfort 530.35 10.03 3065 820119 211642 109554473
Intentional overdose 526.68 10.03 165 823019 132336 109633779
Death 511.58 10.03 3078 820106 695791 109070324
Rheumatoid factor positive 509.98 10.03 2137 821047 129503 109636612
Contraindicated product administered 474.38 10.03 3320 819864 244947 109521168
Pain 472.77 10.03 9840 813344 945115 108821000
Musculoskeletal stiffness 464.06 10.03 3618 819566 276204 109489911
Febrile neutropenia 461.13 10.03 1048 822136 315719 109450396
Impaired healing 451.60 10.03 2755 820429 193962 109572153
Hepatic enzyme increased 432.54 10.03 3961 819223 316931 109449184
Folliculitis 409.80 10.03 2387 820797 165266 109600849
Nasopharyngitis 382.02 10.03 4552 818632 389809 109376306
C-reactive protein abnormal 375.72 10.03 1934 821250 127761 109638354
Blister 370.86 10.03 2929 820255 224447 109541668
Muscle injury 365.27 10.03 2037 821147 138770 109627345
Irritable bowel syndrome 364.38 10.03 2280 820904 161935 109604180
Acute kidney injury 359.48 10.03 3014 820170 632416 109133699
Lower respiratory tract infection 352.23 10.03 3049 820135 240057 109526058
Drug intolerance 344.90 10.03 4578 818606 401934 109364181
Rheumatic fever 342.72 10.03 1810 821374 120769 109645346
Disease progression 337.00 10.03 830 822354 243204 109522911
Fibromyalgia 336.02 10.03 2302 820882 168607 109597508
Exposure during pregnancy 327.93 10.03 2253 820931 165171 109600944
Sleep disorder due to general medical condition, insomnia type 324.02 10.03 1601 821583 104042 109662073
Malignant neoplasm progression 304.46 10.03 519 822665 174048 109592067
Depressed level of consciousness 301.55 10.03 236 822948 112042 109654073
Suicide attempt 297.62 10.03 202 822982 103192 109662923
Osteoarthritis 288.70 10.03 2336 820848 180287 109585828
Sinusitis 283.78 10.03 3417 819767 293271 109472844
Ill-defined disorder 278.84 10.03 2062 821122 154791 109611324
Peripheral swelling 276.03 10.03 4382 818802 399652 109366463
Neutropenia 268.27 10.03 1660 821524 372960 109393155
Hypersensitivity 266.77 10.03 4357 818827 399641 109366474
Type 2 diabetes mellitus 260.90 10.03 2231 820953 175001 109591114
Swollen joint count increased 258.05 10.03 1270 821914 82391 109683724
Constipation 250.19 10.03 1597 821587 356189 109409926
Weight increased 249.22 10.03 4449 818735 415195 109350920
Stomatitis 242.25 10.03 3075 820109 267167 109498948
Cardiac arrest 240.83 10.03 710 822474 196043 109570072
Hepatic function abnormal 239.40 10.03 188 822996 89107 109677008
Inflammation 231.29 10.03 2327 820857 190911 109575204
Rhabdomyolysis 229.79 10.03 337 822847 120064 109646051
Contusion 226.28 10.03 2695 820489 230666 109535449
Cardiac failure 226.08 10.03 682 822502 186944 109579171
Myelosuppression 224.72 10.03 222 822962 94118 109671997
Multiple organ dysfunction syndrome 222.15 10.03 500 822684 151210 109614905
Treatment failure 222.13 10.03 3091 820093 274143 109491972
Overdose 216.80 10.03 948 822236 232846 109533269
Drug resistance 210.45 10.03 78 823106 56296 109709819
Sedation 210.28 10.03 129 823055 69554 109696561
Sickle cell anaemia with crisis 207.54 10.03 303 822881 9242 109756873
Facet joint syndrome 205.79 10.03 1330 821854 95498 109670617
Red blood cell sedimentation rate abnormal 205.08 10.03 518 822666 23991 109742124
Joint range of motion decreased 202.67 10.03 1577 821607 120255 109645860
Lactic acidosis 200.42 10.03 237 822947 92574 109673541
Renal failure 194.48 10.03 945 822239 225629 109540486
Renal impairment 192.96 10.03 735 822449 187710 109578405
Knee arthroplasty 191.15 10.03 973 822211 63975 109702140
Bradycardia 189.72 10.03 562 822622 154955 109611160
Grip strength decreased 189.01 10.03 1131 822053 79043 109687072
Drug ineffective for unapproved indication 188.38 10.03 296 822888 102542 109663573
Somnolence 185.44 10.03 1373 821811 296076 109470039
Blood cholesterol increased 184.84 10.03 2147 821037 182638 109583477
Coma 181.23 10.03 378 822806 117491 109648624
Pregnancy 180.77 10.03 807 822377 50260 109715855
Lip dry 179.12 10.03 1318 821866 98765 109667350
Mobility decreased 175.77 10.03 2611 820573 234811 109531304
Arthritis 175.19 10.03 1964 821220 165622 109600493
Hip arthroplasty 174.06 10.03 850 822334 54963 109711152
Blood pressure systolic abnormal 170.44 10.03 488 822696 24362 109741753
Respiratory arrest 170.32 10.03 112 823072 58187 109707928
Infection 169.78 10.03 3706 819478 358494 109407621
Product use issue 169.40 10.03 3260 819924 308435 109457680
Poisoning deliberate 169.10 10.03 6 823178 26325 109739790
Hypotension 168.78 10.03 2812 820372 521037 109245078
Neoplasm progression 168.15 10.03 140 823044 64455 109701660
Blood pressure fluctuation 167.19 10.03 1041 822143 73783 109692332
Respiratory failure 166.33 10.03 931 822253 214401 109551714
Sopor 165.30 10.03 35 823149 36511 109729604
Off label use 163.64 10.03 9322 813862 1490863 108275252
Drug reaction with eosinophilia and systemic symptoms 163.38 10.03 223 822961 81872 109684243
Blood pressure systolic increased 162.52 10.03 1117 822067 81874 109684241
Intentional product misuse 162.31 10.03 480 822704 132424 109633691
Hypoglycaemia 160.10 10.03 395 822789 115709 109650406
Injury 160.01 10.03 2020 821164 175245 109590870
Blood pressure diastolic abnormal 159.03 10.03 488 822696 25327 109740788
Hyperhidrosis 154.52 10.03 792 822392 186506 109579609
Serotonin syndrome 154.23 10.03 128 823056 59025 109707090
Musculoskeletal pain 152.79 10.03 2056 821128 180967 109585148
Intentional product use issue 151.52 10.03 2641 820543 245265 109520850
C-reactive protein increased 148.79 10.03 2364 820820 215555 109550560
Live birth 148.61 10.03 956 822228 68528 109697587
Cytokine release syndrome 143.96 10.03 187 822997 70119 109695996
Bursitis 143.79 10.03 1540 821644 128378 109637737
Altered state of consciousness 142.62 10.03 131 823053 57495 109708620
Hyponatraemia 139.80 10.03 996 822188 216657 109549458
Cytomegalovirus infection 139.27 10.03 120 823064 54324 109711791
Angioedema 138.26 10.03 332 822852 98168 109667947
Abortion spontaneous 134.59 10.03 559 822625 33723 109732392
Red blood cell sedimentation rate increased 132.67 10.03 1018 822166 77284 109688831
Cardio-respiratory arrest 132.49 10.03 431 822753 115405 109650710
Deep vein thrombosis postoperative 130.03 10.03 821 822363 58470 109707645
Anaemia 129.66 10.03 3091 820093 543995 109222120
Thrombocytopenia 128.54 10.03 1825 821359 347060 109419055
Drug dependence 128.25 10.03 110 823074 49910 109716205
Agitation 127.67 10.03 423 822761 112628 109653487
Liver injury 125.66 10.03 1690 821494 148723 109617392
Gastrointestinal disorder 125.48 10.03 2513 820671 239439 109526676
Hyperglycaemia 124.90 10.03 280 822904 84810 109681305
Wound infection 123.83 10.03 1179 822005 95286 109670829
Poisoning 123.47 10.03 32 823152 29073 109737042
Breast cancer stage III 123.30 10.03 1009 822175 78108 109688007
Obesity 122.82 10.03 1338 821846 112013 109654102
Tachycardia 120.28 10.03 1092 822092 225553 109540562
Sepsis 119.99 10.03 1714 821470 325632 109440483
Joint effusion 119.41 10.03 385 822799 20520 109745595
Peripheral venous disease 118.56 10.03 1049 822135 83068 109683047
Anaphylactic shock 118.54 10.03 125 823059 51421 109714694
Shock 117.67 10.03 135 823049 53453 109712662
Sciatica 116.47 10.03 1125 822059 91274 109674841
Pain in extremity 114.92 10.03 4574 818610 482544 109283571
Electrocardiogram QT prolonged 114.10 10.03 421 822763 108539 109657576
Ventricular fibrillation 113.25 10.03 85 823099 41228 109724887
Product use in unapproved indication 113.17 10.03 2502 820682 444875 109321240
Syncope 112.25 10.03 965 822219 201571 109564544
Intentional self-injury 110.57 10.03 71 823113 37358 109728757
Hypoxia 109.46 10.03 543 822641 128972 109637143
Hepatic failure 109.44 10.03 216 822968 68523 109697592
Neuropathy peripheral 108.60 10.03 834 822350 178443 109587672
Condition aggravated 108.35 10.03 6590 816594 728246 109037869
Drug use disorder 106.85 10.03 7 823177 18067 109748048
Road traffic accident 105.63 10.03 1244 821940 106154 109659961
Autoimmune disorder 104.14 10.03 839 822345 64644 109701471
Sedation complication 103.20 10.03 13 823171 19842 109746273
Disability assessment scale score increased 102.35 10.03 142 823042 4128 109761987
Bone erosion 100.38 10.03 640 822544 45731 109720384
Nausea 100.05 10.03 7882 815302 1227808 108538307
Palmar-plantar erythrodysaesthesia syndrome 99.47 10.03 95 823089 40930 109725185
Gait inability 99.00 10.03 1495 821689 134881 109631234
Foot deformity 98.78 10.03 659 822525 47821 109718294
Disseminated intravascular coagulation 98.49 10.03 97 823087 41189 109724926
General physical health deterioration 97.61 10.03 3982 819202 421313 109344802
Hyperkalaemia 97.45 10.03 601 822583 135195 109630920
Psoriasis 97.16 10.03 1523 821661 138470 109627645
Metabolic acidosis 97.00 10.03 397 822787 99347 109666768
No adverse event 96.56 10.03 258 822926 73581 109692534
Neutrophil count decreased 96.04 10.03 518 822666 120423 109645692
Suspected suicide 95.77 10.03 4 823180 15195 109750920
Joint stiffness 95.50 10.03 840 822344 66403 109699712
Neurotoxicity 95.22 10.03 104 823080 42103 109724012
Respiratory depression 92.77 10.03 62 823122 31939 109734176
Injection site reaction 92.65 10.03 1043 822141 88027 109678088
Pulmonary fibrosis 92.55 10.03 1164 822020 100878 109665237
Ventricular tachycardia 92.47 10.03 143 823041 49866 109716249
Cognitive disorder 92.36 10.03 337 822847 87174 109678941
Blood pressure diastolic decreased 91.56 10.03 517 822667 35368 109730747
Fatigue 91.43 10.03 10360 812824 1205598 108560517
Leukopenia 91.14 10.03 690 822494 148101 109618014
Adjustment disorder with depressed mood 90.91 10.03 599 822585 43284 109722831
Aspergillus infection 89.80 10.03 39 823145 25577 109740538
Cardiogenic shock 89.72 10.03 182 823002 57156 109708959
Chest discomfort 89.47 10.03 844 822340 173004 109593111
Lower limb fracture 89.42 10.03 906 822278 74442 109691673
Rash 88.70 10.03 7177 816007 813787 108952328
Dislocation of vertebra 88.29 10.03 593 822591 43128 109722987
Myalgia 87.71 10.03 1147 822037 221234 109544881
Cerebral haemorrhage 87.25 10.03 224 822960 64744 109701371
Hypoaesthesia 87.20 10.03 3005 820179 311218 109454897
Dry skin 86.08 10.03 460 822724 107193 109658922
Appendicolith 85.84 10.03 5 823179 14250 109751865
Cardiac failure congestive 85.20 10.03 716 822468 150284 109615831
Enthesopathy 84.56 10.03 244 822940 12234 109753881
Acute hepatic failure 84.35 10.03 88 823096 36380 109729735
Post transplant lymphoproliferative disorder 84.20 10.03 9 823175 15604 109750511
Heart rate decreased 83.79 10.03 964 822220 81792 109684323
Restlessness 83.49 10.03 184 823000 56075 109710040
Wrong technique in product usage process 83.48 10.03 350 822834 86998 109679117
Adverse event 83.36 10.03 1204 821980 107605 109658510
Ascites 81.38 10.03 384 822800 92424 109673691
Tremor 81.25 10.03 1039 822145 201193 109564922
Osteoporosis 80.25 10.03 997 822187 86155 109679960
Seizure 80 10.03 1161 822023 220024 109546091
Hepatocellular injury 79.87 10.03 160 823024 50482 109715633
Therapy partial responder 79.61 10.03 95 823089 36966 109729149
Blood creatinine increased 79.01 10.03 925 822259 181964 109584151
Polyarthritis 78.23 10.03 314 822870 18649 109747466
Hypercholesterolaemia 77.66 10.03 1025 822159 89812 109676303
Dry mouth 77.41 10.03 1993 821191 197955 109568160
Suicidal ideation 77.00 10.03 398 822786 93539 109672576
Vision blurred 76.35 10.03 604 822580 128418 109637697
Dehydration 76.22 10.03 1544 821640 277967 109488148
Temperature regulation disorder 75.73 10.03 5 823179 12821 109753294
Orthostatic hypotension 75.40 10.03 247 822937 66002 109700113
Joint destruction 75.14 10.03 215 822969 10728 109755387
Juvenile idiopathic arthritis 75.07 10.03 149 823035 5858 109760257
Thrombotic microangiopathy 74.85 10.03 64 823120 29085 109737030
Cytomegalovirus infection reactivation 74.32 10.03 22 823162 18311 109747804
Mydriasis 74.15 10.03 36 823148 22121 109743994
Myocardial infarction 73.82 10.03 996 822188 191087 109575028
Rheumatoid nodule 73.53 10.03 323 822861 19973 109746142
Cholestasis 72.42 10.03 242 822942 64276 109701839
Platelet count decreased 72.12 10.03 1243 821941 229200 109536915
Drug withdrawal syndrome 72.11 10.03 107 823077 37947 109728168
Venoocclusive liver disease 72.07 10.03 13 823171 15194 109750921
Cerebral infarction 71.73 10.03 176 823008 51662 109714453
Proteinuria 71.56 10.03 117 823067 39901 109726214
Anaphylactic reaction 71.45 10.03 527 822657 113773 109652342
Bronchopulmonary aspergillosis 71.42 10.03 70 823114 29793 109736322
Hypokalaemia 70.49 10.03 945 822239 181503 109584612
Blood glucose increased 70.43 10.03 638 822546 131858 109634257
Exposure to toxic agent 70.41 10.03 7 823177 12851 109753264
Disease recurrence 70.30 10.03 225 822959 60559 109705556
Pathogen resistance 70.21 10.03 22 823162 17650 109748465
BK virus infection 69.55 10.03 8 823176 13098 109753017
Accidental exposure to product 69.03 10.03 170 823014 49838 109716277
Blood creatine phosphokinase increased 68.49 10.03 295 822889 72782 109693333
White blood cell count decreased 68.39 10.03 1248 821936 228142 109537973
C-reactive protein 68.38 10.03 423 822761 29908 109736207
Sleep disorder 68.36 10.03 1950 821234 196694 109569421
Atrial fibrillation 68.27 10.03 1250 821934 228392 109537723
Torsade de pointes 67.96 10.03 42 823142 22558 109743557
Creatinine renal clearance decreased 67.76 10.03 39 823145 21776 109744339
Asphyxia 67.70 10.03 12 823172 14203 109751912
Posterior reversible encephalopathy syndrome 67.34 10.03 92 823092 33769 109732346
Body temperature decreased 66.97 10.03 488 822696 36447 109729668
Disturbance in attention 65.91 10.03 238 822946 61757 109704358
Onychomadesis 65.65 10.03 572 822612 45091 109721024
Acute graft versus host disease 65.59 10.03 9 823175 12872 109753243
Encephalopathy 65.55 10.03 345 822839 80710 109685405
Ejection fraction decreased 65.47 10.03 128 823056 40752 109725363
Neuroleptic malignant syndrome 65.29 10.03 95 823089 33964 109732151
Night sweats 65.26 10.03 1379 821805 132604 109633511
Substance abuse 65.17 10.03 8 823176 12455 109753660
Blood pressure diastolic increased 64.90 10.03 295 822889 18512 109747603
Interstitial lung disease 64.80 10.03 693 822491 138641 109627474
Skin exfoliation 64.41 10.03 385 822799 87266 109678849
Haematotoxicity 63.64 10.03 39 823145 21043 109745072
Onychomycosis 63.62 10.03 498 822686 38033 109728082
Brain oedema 63.37 10.03 83 823101 31015 109735100
Psychotic disorder 62.87 10.03 183 823001 50754 109715361
Caesarean section 62.05 10.03 235 822949 13582 109752533
Tenosynovitis 61.96 10.03 263 822921 16020 109750095
Hallucination 61.34 10.03 472 822712 100960 109665155
Aggression 61.18 10.03 230 822954 58980 109707135
Loss of consciousness 61.06 10.03 1060 822124 195246 109570869
Miosis 60.55 10.03 45 823139 21938 109744177
Disorientation 60.45 10.03 295 822889 70376 109695739
Immune reconstitution inflammatory syndrome 59.64 10.03 23 823161 16203 109749912
Joint laxity 59.53 10.03 83 823101 2424 109763691
Lupus-like syndrome 59.18 10.03 512 822672 40280 109725835
Laryngitis 58.77 10.03 527 822657 41884 109724231
Personality disorder 58.66 10.03 12 823172 12825 109753290
Drug level increased 58.49 10.03 172 823012 47547 109718568
Dysphagia 58.45 10.03 798 822386 152802 109613313
Respiratory distress 58.05 10.03 289 822895 68585 109697530
Acute respiratory distress syndrome 58.04 10.03 202 822982 52996 109713119
Second primary malignancy 58.01 10.03 31 823153 18037 109748078
Dyspnoea 57.82 10.03 7287 815897 1099585 108666530
Withdrawal syndrome 57.76 10.03 90 823094 31290 109734825
Myoclonus 57.59 10.03 98 823086 32900 109733215
Dysarthria 57.42 10.03 378 822806 83743 109682372
Exostosis 57.15 10.03 558 822626 45398 109720717
Blepharospasm 56.90 10.03 642 822542 54209 109711906
Abnormal behaviour 56.85 10.03 129 823055 38910 109727205
Extrapyramidal disorder 56.84 10.03 79 823105 28788 109737327
Neurologic neglect syndrome 56.80 10.03 3 823181 9295 109756820
Aphasia 56.62 10.03 236 822948 58761 109707354
Hepatic cirrhosis 56.11 10.03 759 822425 66867 109699248
Pulmonary alveolar haemorrhage 55.82 10.03 41 823143 20109 109746006
Pulmonary oedema 55.56 10.03 480 822704 100179 109665936
Gamma-glutamyltransferase increased 55.33 10.03 251 822933 61058 109705057
Hemiplegia 54.95 10.03 53 823131 22729 109743386
Transplant rejection 54.91 10.03 61 823123 24506 109741609
Haemoptysis 54.79 10.03 309 822875 71045 109695070
Unintentional medical device removal 54.13 10.03 3 823181 8920 109757195
X-ray abnormal 54.03 10.03 476 822708 37641 109728474
Osteonecrosis of jaw 53.97 10.03 180 823004 47837 109718278
Graft versus host disease 53.76 10.03 37 823147 18769 109747346
Device difficult to use 53.75 10.03 37 823147 18768 109747347
Melaena 53.75 10.03 296 822888 68461 109697654
Balance disorder 53.69 10.03 581 822603 115979 109650136
Loss of personal independence in daily activities 53.65 10.03 1480 821704 148540 109617575
Bronchospasm 53.52 10.03 89 823095 30150 109735965
Gestational diabetes 53.51 10.03 148 823036 7241 109758874
Ear infection 53.25 10.03 707 822477 62025 109704090
Status epilepticus 53.07 10.03 96 823088 31475 109734640
Exposure via skin contact 52.89 10.03 16 823168 13131 109752984
Mucormycosis 52.78 10.03 8 823176 10620 109755495
Finger deformity 52.61 10.03 424 822760 32668 109733447
Akathisia 52.58 10.03 31 823153 17082 109749033
Lung disorder 52.22 10.03 1731 821453 178316 109587799
Localised infection 52.22 10.03 520 822664 42528 109723587
Tachypnoea 52.00 10.03 137 823047 39258 109726857
Oedema 51.84 10.03 1982 821202 207994 109558121
Anti-cyclic citrullinated peptide antibody 51.18 10.03 288 822896 19676 109746439
Drug dose omission by device 51.04 10.03 22 823162 14494 109751621
Adenovirus infection 50.82 10.03 10 823174 10984 109755131
Cytomegalovirus viraemia 50.71 10.03 35 823149 17729 109748386
Retinitis 50.21 10.03 412 822772 31915 109734200
Coagulopathy 49.75 10.03 148 823036 40763 109725352
Palpitations 49.73 10.03 859 822325 158353 109607762
Prescribed overdose 49.21 10.03 921 822263 86660 109679455
COVID-19 49.10 10.03 1418 821766 243642 109522473
Wheezing 49.05 10.03 2347 820837 252883 109513232
Polyomavirus-associated nephropathy 49.01 10.03 3 823181 8198 109757917
Basal cell carcinoma 48.85 10.03 534 822650 44736 109721379
Graft versus host disease in gastrointestinal tract 48.80 10.03 5 823179 8963 109757152
Haemophagocytic lymphohistiocytosis 48.67 10.03 101 823083 31458 109734657
Cytopenia 48.49 10.03 94 823090 30022 109736093
Carotid artery thrombosis 48.45 10.03 7 823177 9631 109756484
Diabetic ketoacidosis 48.42 10.03 156 823028 41902 109724213
Diarrhoea 48.02 10.03 7600 815584 1131905 108634210
Arrhythmia 47.81 10.03 312 822872 69263 109696852
Pleural effusion 47.43 10.03 985 822199 176724 109589391
Irritability 47.29 10.03 189 822995 47620 109718495
Blood calcium decreased 47.05 10.03 125 823059 35720 109730395
Unresponsive to stimuli 46.97 10.03 280 822904 63510 109702605
Angina pectoris 46.63 10.03 272 822912 62023 109704092
Lupus vulgaris 46.42 10.03 420 822764 33463 109732652
Forced expiratory volume decreased 46.28 10.03 20 823164 13156 109752959
Metastases to bone 46.22 10.03 103 823081 31269 109734846
Metastases to liver 45.99 10.03 124 823060 35262 109730853
Pyrexia 45.69 10.03 5923 817261 892342 108873773
Chronic kidney disease 45.66 10.03 356 822828 75935 109690180
Prescribed underdose 45.56 10.03 710 822474 64464 109701651
Joint dislocation 45.42 10.03 421 822763 33769 109732346
Metastases to central nervous system 45.37 10.03 62 823122 22755 109743360
Pancreatitis acute 45.21 10.03 263 822921 60011 109706104
Acute graft versus host disease in skin 45.19 10.03 12 823172 10728 109755387
Hypothermia 45.09 10.03 79 823105 26223 109739892
Eosinophilia 44.97 10.03 250 822934 57686 109708429
Coordination abnormal 44.88 10.03 74 823110 25154 109740961
Acute chest syndrome 44.63 10.03 66 823118 2037 109764078
Face oedema 44.47 10.03 116 823068 33353 109732762
Nail disorder 44.33 10.03 641 822543 57294 109708821
Psychomotor hyperactivity 43.53 10.03 52 823132 20225 109745890
Red blood cell sedimentation rate 43.41 10.03 110 823074 5104 109761011
Blood bilirubin increased 43.40 10.03 359 822825 75613 109690502
Blood pressure decreased 43.40 10.03 599 822585 114492 109651623
Speech disorder 43.37 10.03 274 822910 61295 109704820
Clostridium difficile colitis 43.34 10.03 173 823011 43605 109722510
Septic shock 43.27 10.03 869 822315 156659 109609456
Hyperthermia 43.11 10.03 57 823127 21215 109744900
Mania 42.89 10.03 55 823129 20741 109745374
Pulmonary embolism 42.71 10.03 1242 821942 213232 109552883
Rash erythematous 42.63 10.03 396 822788 81436 109684679
Tendonitis 42.45 10.03 336 822848 25747 109740368
Maternal exposure timing unspecified 42.42 10.03 285 822899 20728 109745387
Appendicitis 42.31 10.03 93 823091 28371 109737744
Erythema multiforme 42.28 10.03 57 823127 21040 109745075
Wheelchair user 41.73 10.03 141 823043 7701 109758414
Tumour lysis syndrome 41.51 10.03 106 823078 30695 109735420
Injection site erythema 41.33 10.03 955 822229 93221 109672894
Agranulocytosis 40.91 10.03 280 822904 61480 109704635
Chronic graft versus host disease 40.88 10.03 10 823174 9447 109756668
Coronary artery disease 40.85 10.03 339 822845 71351 109694764
Maternal exposure before pregnancy 40.77 10.03 133 823051 7132 109758983
Hemiparesis 40.67 10.03 178 823006 43725 109722390
Blood phosphorus increased 40.60 10.03 37 823147 16303 109749812
Aspartate aminotransferase increased 40.49 10.03 894 822290 159042 109607073
Flushing 40.25 10.03 543 822641 104193 109661922
Blood alkaline phosphatase increased 40.16 10.03 336 822848 70599 109695516
Nodule 39.98 10.03 395 822789 32236 109733879
Rebound effect 39.89 10.03 31 823153 14775 109751340
Tongue disorder 39.84 10.03 211 822973 14087 109752028
Inappropriate antidiuretic hormone secretion 39.36 10.03 125 823059 33726 109732389
Acute respiratory failure 39.29 10.03 364 822820 74896 109691219
Hepatotoxicity 39.29 10.03 293 822891 63107 109703008
Epstein-Barr virus infection 39.23 10.03 49 823135 18689 109747426
Dermatitis atopic 39.17 10.03 82 823102 25459 109740656
Acute generalised exanthematous pustulosis 39.05 10.03 63 823121 21601 109744514
Femur fracture 38.92 10.03 504 822680 43965 109722150
Alanine aminotransferase abnormal 38.86 10.03 155 823029 9179 109756936
Ischaemic stroke 38.40 10.03 167 823017 41096 109725019
Neck deformity 38.32 10.03 58 823126 1828 109764287
Vomiting 38.28 10.03 6074 817110 904601 108861514
Obstructive airways disorder 38.11 10.03 195 822989 45954 109720161
Fracture 38.00 10.03 315 822869 24473 109741642
Bacteraemia 37.98 10.03 174 823010 42216 109723899
Emotional distress 37.89 10.03 188 822996 44659 109721456
Multiple-drug resistance 37.88 10.03 26 823158 13209 109752906
Glycosylated haemoglobin increased 37.78 10.03 74 823110 23545 109742570
Back injury 37.70 10.03 528 822656 46871 109719244
Hypophosphataemia 37.56 10.03 124 823060 33058 109733057
Drug tolerance decreased 37.54 10.03 341 822843 27199 109738916
Acute myeloid leukaemia 37.47 10.03 151 823033 37959 109728156
Anuria 37.45 10.03 78 823106 24263 109741852
Neck pain 37.30 10.03 1190 821994 121940 109644175
Mental status changes 37.27 10.03 374 822810 75748 109690367
Hyperbilirubinaemia 37.26 10.03 111 823073 30560 109735555
Dyskinesia 37.25 10.03 227 822957 51219 109714896
Hyperuricaemia 37.19 10.03 32 823152 14499 109751616
Graft versus host disease in skin 37.13 10.03 8 823176 8246 109757869
Migraine 36.99 10.03 1597 821587 170055 109596060
Procedural pain 36.84 10.03 138 823046 35427 109730688
Stress cardiomyopathy 36.71 10.03 38 823146 15768 109750347
Device expulsion 36.67 10.03 113 823071 30778 109735337
Cerebrovascular accident 36.55 10.03 1048 822136 180236 109585879
Nocardiosis 36.35 10.03 6 823178 7480 109758635
Premature labour 36.35 10.03 150 823034 9022 109757093
Cystitis haemorrhagic 36.28 10.03 23 823161 12186 109753929
Klebsiella infection 36.25 10.03 58 823126 19951 109746164
Asthma-chronic obstructive pulmonary disease overlap syndrome 35.96 10.03 3 823181 6341 109759774
Paradoxical drug reaction 35.94 10.03 14 823170 9803 109756312
Pseudomonas infection 35.90 10.03 98 823086 27755 109738360
Oliguria 35.80 10.03 52 823132 18605 109747510
Lymphocyte count decreased 35.73 10.03 264 822920 56979 109709136
Diffuse large B-cell lymphoma recurrent 35.64 10.03 3 823181 6296 109759819
Stevens-Johnson syndrome 35.52 10.03 204 822980 46697 109719418
Electrocardiogram QRS complex prolonged 35.42 10.03 27 823157 12994 109753121
Skin haemorrhage 35.37 10.03 83 823101 24744 109741371
Ileus 35.36 10.03 114 823070 30615 109735500
Neck mass 35.34 10.03 97 823087 4724 109761391
Bone pain 35.32 10.03 312 822872 64821 109701294
Acute myocardial infarction 35.29 10.03 426 822758 83351 109682764
Hallucination, visual 35.23 10.03 163 823021 39442 109726673
Parkinsonism 35.07 10.03 70 823114 22117 109743998
Food allergy 35.04 10.03 59 823125 19889 109746226
Smear cervix abnormal 34.77 10.03 68 823116 2644 109763471
Diabetes mellitus 34.75 10.03 525 822659 98856 109667259
Disability 34.70 10.03 361 822823 29862 109736253
Premature rupture of membranes 34.69 10.03 94 823090 4543 109761572
Toxic skin eruption 34.58 10.03 98 823086 27417 109738698
Metastases to lung 34.57 10.03 75 823109 22988 109743127
Rash maculo-papular 34.56 10.03 369 822815 73853 109692262
Hypothyroidism 34.53 10.03 361 822823 72538 109693577
Muscle twitching 34.48 10.03 111 823073 29824 109736291
Tenderness 34.46 10.03 353 822831 29084 109737031
Cardiotoxicity 34.45 10.03 45 823139 16836 109749279
Haemorrhage intracranial 34.37 10.03 106 823078 28863 109737252
Latent tuberculosis 34.26 10.03 85 823099 3892 109762223
Hepatitis B reactivation 34.19 10.03 7 823177 7477 109758638
Chills 34.19 10.03 1119 822065 189461 109576654
Injection site pruritus 34.17 10.03 554 822630 50704 109715411
Synovial cyst 34.16 10.03 172 823012 11258 109754857
End stage renal disease 33.73 10.03 68 823116 21405 109744710
Bradyphrenia 33.62 10.03 23 823161 11705 109754410
Gastrointestinal haemorrhage 33.58 10.03 956 822228 164562 109601553
Colorectal cancer 33.36 10.03 13 823171 9101 109757014
Colitis 33.27 10.03 548 822636 101775 109664340
Febrile bone marrow aplasia 33.20 10.03 49 823135 17416 109748699
Multiple sclerosis relapse 33.16 10.03 228 822956 50012 109716103
Potentiating drug interaction 33.16 10.03 23 823161 11620 109754495
Cardiac failure acute 33.11 10.03 82 823102 23996 109742119
Nephropathy toxic 32.99 10.03 100 823084 27378 109738737
Spinal stenosis 32.97 10.03 249 822935 18807 109747308
Arthritis infective 32.63 10.03 159 823025 10270 109755845
Device leakage 32.52 10.03 43 823141 16005 109750110
Cardiac failure chronic 32.31 10.03 33 823151 13778 109752337
Ankylosing spondylitis 32.27 10.03 213 822971 15399 109750716
Myasthenia gravis 32.21 10.03 70 823114 21441 109744674
Motor dysfunction 32.11 10.03 85 823099 24321 109741794
Scleritis 32.03 10.03 101 823083 5319 109760796
Sinus tachycardia 31.86 10.03 197 822987 44296 109721819
Confusional state 31.79 10.03 3969 819215 464711 109301404
Tuberculosis 31.74 10.03 234 822950 17540 109748575
Infective pulmonary exacerbation of cystic fibrosis 31.58 10.03 38 823146 14733 109751382
Enterocolitis 31.51 10.03 58 823126 18891 109747224
Sexual dysfunction 31.50 10.03 12 823172 8518 109757597
Rhinitis allergic 31.48 10.03 53 823131 17869 109748246
Haemodynamic instability 31.44 10.03 78 823106 22810 109743305
Dissociation 31.43 10.03 17 823167 9825 109756290
Urinary retention 31.42 10.03 349 822835 69334 109696781
Bacterial infection 31.35 10.03 207 822977 45829 109720286
Respiratory acidosis 31.26 10.03 34 823150 13792 109752323
Feeling abnormal 31.25 10.03 1066 822118 179645 109586470
Adjustment disorder 31.18 10.03 21 823163 10774 109755341
Seronegative arthritis 31.11 10.03 186 822998 12991 109753124
Mouth ulceration 30.88 10.03 517 822667 47621 109718494
Jaundice cholestatic 30.79 10.03 38 823146 14570 109751545
Shock haemorrhagic 30.72 10.03 102 823082 27145 109738970
Multiple fractures 30.67 10.03 140 823044 8800 109757315
Leukocytosis 30.46 10.03 255 822929 53573 109712542
Blood parathyroid hormone decreased 30.42 10.03 184 823000 12905 109753210
Fear 30.35 10.03 81 823103 23112 109743003
Labelled drug-drug interaction medication error 30.16 10.03 114 823070 29188 109736927
Sinus bradycardia 30.15 10.03 115 823069 29368 109736747
Limb deformity 30.12 10.03 78 823106 3668 109762447
Device use error 30.06 10.03 15 823169 9074 109757041
Multiple drug therapy 30.06 10.03 11 823173 8003 109758112
Pruritus genital 30.00 10.03 6 823178 6516 109759599
Cytomegalovirus chorioretinitis 29.92 10.03 8 823176 7120 109758995
Liver disorder 29.90 10.03 1320 821864 140923 109625192
Pulmonary arterial hypertension 29.59 10.03 133 823051 32435 109733680
Glomerular filtration rate decreased 29.57 10.03 113 823071 28843 109737272
Dystonia 29.51 10.03 96 823088 25709 109740406
Blood urea increased 29.47 10.03 264 822920 54693 109711422
Endophthalmitis 29.44 10.03 12 823172 8175 109757940
Lung opacity 29.41 10.03 26 823158 11626 109754489
Device related infection 29.34 10.03 173 823011 39346 109726769
Hypomania 29.30 10.03 20 823164 10190 109755925
Rotator cuff repair 29.28 10.03 57 823127 2209 109763906
Candida infection 29.21 10.03 223 822961 47786 109718329
Atrial tachycardia 29.09 10.03 16 823168 9162 109756953
Skin ulcer 29.04 10.03 649 822535 62996 109703119
Erythema 28.99 10.03 1825 821359 289622 109476493
Proctitis 28.88 10.03 51 823133 16876 109749239
Pemphigoid 28.79 10.03 65 823119 19642 109746473
Lip swelling 28.68 10.03 240 822944 50427 109715688
Product prescribing error 28.67 10.03 244 822940 51087 109715028
Pre-eclampsia 28.60 10.03 134 823050 8516 109757599
Immune effector cell-associated neurotoxicity syndrome 28.56 10.03 41 823143 14741 109751374
Sleep terror 28.55 10.03 7 823177 6603 109759512
Granuloma skin 28.42 10.03 162 823022 11121 109754994
Generalised tonic-clonic seizure 28.31 10.03 265 822919 54415 109711700
Antinuclear antibody positive 28.13 10.03 139 823045 9029 109757086
Generalised oedema 28.13 10.03 125 823059 30579 109735536
Fluid retention 28.11 10.03 513 822671 93794 109672321
Paraesthesia oral 27.96 10.03 142 823042 33529 109732586
Cyanosis 27.90 10.03 120 823064 29621 109736494
Dermatitis acneiform 27.85 10.03 32 823152 12663 109753452
Skin toxicity 27.74 10.03 28 823156 11755 109754360
Haemorrhage 27.69 10.03 594 822590 106098 109660017
Blood lactic acid increased 27.60 10.03 47 823137 15774 109750341
Pneumothorax 27.52 10.03 152 823032 35133 109730982
Malignant mediastinal neoplasm 27.46 10.03 42 823142 1336 109764779
Gastroenteritis viral 27.37 10.03 354 822830 30872 109735243
Sensory loss 27.28 10.03 76 823108 21381 109744734
Vasoplegia syndrome 27.23 10.03 4 823180 5435 109760680
Pulmonary congestion 27.21 10.03 128 823056 30838 109735277
Bladder cancer 27.21 10.03 70 823114 20222 109745893
Pneumonia bacterial 27.13 10.03 102 823082 26159 109739956
Mental disorder 27.13 10.03 173 823011 38618 109727497
Hypoalbuminaemia 27.12 10.03 117 823067 28857 109737258
Hepatitis fulminant 27.02 10.03 15 823169 8545 109757570
Eating disorder 26.86 10.03 128 823056 30730 109735385
Transaminases increased 26.83 10.03 322 822862 63068 109703047
Affect lability 26.80 10.03 62 823122 18575 109747540
Synovial disorder 26.68 10.03 65 823119 2942 109763173
Anxiety 26.67 10.03 2208 820976 342870 109423245
Paralysis 26.61 10.03 47 823137 15553 109750562
Acute coronary syndrome 26.41 10.03 86 823098 23026 109743089
Hypogammaglobulinaemia 26.36 10.03 70 823114 20006 109746109
Liver function test increased 26.35 10.03 854 822330 87694 109678421
Virologic failure 26.34 10.03 3 823181 4949 109761166
Pulmonary haemorrhage 25.94 10.03 52 823132 16404 109749711
Immune-mediated myositis 25.86 10.03 7 823177 6179 109759936
Euglycaemic diabetic ketoacidosis 25.82 10.03 29 823155 11594 109754521
Subdural haematoma 25.80 10.03 162 823022 36292 109729823
Myopathy 25.76 10.03 97 823087 24863 109741252
Drug tolerance 25.55 10.03 211 822973 16374 109749741
Blood lactate dehydrogenase increased 25.55 10.03 209 822975 44125 109721990
Polyneuropathy 25.46 10.03 137 823047 31875 109734240
Kidney transplant rejection 25.46 10.03 31 823153 11956 109754159
Pancytopenia 25.42 10.03 1850 821334 207763 109558352
Myocarditis 25.39 10.03 126 823058 29929 109736186
Rheumatoid lung 25.25 10.03 80 823104 4224 109761891
Affective disorder 25.02 10.03 28 823156 11213 109754902
Hyperlipidaemia 25.01 10.03 160 823024 35688 109730427
Synovial fluid analysis 24.91 10.03 59 823125 2622 109763493
Diplopia 24.83 10.03 196 822988 41698 109724417
Lymphopenia 24.72 10.03 186 822998 39984 109726131
Pulseless electrical activity 24.70 10.03 55 823129 16702 109749413
Palmoplantar keratoderma 24.69 10.03 5 823179 5382 109760733
Premature delivery 24.67 10.03 342 822842 30290 109735825
Ankle arthroplasty 24.64 10.03 57 823127 2494 109763621
Respiration abnormal 24.62 10.03 22 823162 9787 109756328
Depressed mood 24.56 10.03 312 822872 60497 109705618
Product dose omission issue 24.55 10.03 2061 821123 319721 109446394
Panniculitis 24.42 10.03 199 822985 15383 109750732
Muscle rigidity 24.40 10.03 94 823090 23937 109742178
Paranoia 24.38 10.03 85 823099 22289 109743826
Joint injury 24.37 10.03 426 822758 39568 109726547
Nasal polyps 24.16 10.03 38 823146 13162 109752953
Vaginal flatulence 24.14 10.03 33 823151 12111 109754004
Product administered to patient of inappropriate age 24.07 10.03 15 823169 8021 109758094
Hepatitis cholestatic 24.02 10.03 60 823124 17506 109748609
Diabetes mellitus inadequate control 23.92 10.03 127 823057 29648 109736467
Progressive multifocal leukoencephalopathy 23.84 10.03 100 823084 24856 109741259
Gangrene 23.79 10.03 54 823130 16287 109749828
Intervertebral disc degeneration 23.68 10.03 222 822962 17863 109748252
Exposure via ingestion 23.63 10.03 4 823180 4896 109761219
Haematoma 23.63 10.03 300 822884 58176 109707939
Acidosis 23.61 10.03 87 823097 22444 109743671
Hypercapnia 23.55 10.03 29 823155 11130 109754985
Eye pruritus 23.53 10.03 145 823039 32630 109733485
Blindness 23.51 10.03 166 823018 36193 109729922
Bone disorder 23.33 10.03 251 822933 20941 109745174
Cleft lip and palate 23.28 10.03 28 823156 704 109765411
Immunosuppressant drug level increased 23.17 10.03 32 823152 11692 109754423
Myocardial ischaemia 23.04 10.03 111 823073 26573 109739542
Diabetes insipidus 23.03 10.03 10 823174 6560 109759555
Tenosynovitis stenosans 23.02 10.03 69 823115 3534 109762581
Transplant dysfunction 23.00 10.03 17 823167 8311 109757804
Drug effective for unapproved indication 23.00 10.03 44 823140 14123 109751992
Foot fracture 22.98 10.03 291 822893 25255 109740860
Hyperpyrexia 22.90 10.03 16 823168 8053 109758062
Pneumatosis intestinalis 22.80 10.03 18 823166 8511 109757604
Radiculopathy 22.76 10.03 71 823113 19265 109746850
Viral mutation identified 22.71 10.03 3 823181 4416 109761699
Cardiomyopathy 22.70 10.03 151 823033 33374 109732741
Hypertransaminasaemia 22.67 10.03 98 823086 24157 109741958
Normal newborn 22.58 10.03 256 822928 21640 109744475
Loose body in joint 22.49 10.03 39 823145 1381 109764734
Chronic sinusitis 22.45 10.03 103 823081 24981 109741134
Acute graft versus host disease in intestine 22.44 10.03 7 823177 5632 109760483
Alanine aminotransferase increased 22.43 10.03 1128 822056 182645 109583470
Right ventricular failure 22.39 10.03 108 823076 25846 109740269
Pneumonia aspiration 22.33 10.03 448 822736 80785 109685330
Accidental death 22.24 10.03 5 823179 5004 109761111
Product preparation error 22.20 10.03 29 823155 10850 109755265
Epilepsy 22.19 10.03 935 822249 99274 109666841
Product administration error 22.11 10.03 174 823010 37043 109729072
Strongyloidiasis 22.09 10.03 5 823179 4981 109761134
Gastric haemorrhage 22.04 10.03 54 823130 15861 109750254
Hepatitis acute 22.02 10.03 69 823115 18697 109747418
Peripheral sensory neuropathy 22.02 10.03 58 823126 16622 109749493
Poor venous access 21.91 10.03 279 822905 24243 109741872
Rales 21.89 10.03 102 823082 24637 109741478
Hydrops foetalis 21.83 10.03 28 823156 753 109765362
Renal injury 21.83 10.03 69 823115 18644 109747471
Anosmia 21.80 10.03 37 823147 12435 109753680
Pain in jaw 21.64 10.03 260 822924 50917 109715198
Acute lymphocytic leukaemia recurrent 21.61 10.03 8 823176 5779 109760336
Haematuria 21.57 10.03 462 822722 82543 109683572
Toxic encephalopathy 21.56 10.03 51 823133 15163 109750952
Human herpesvirus 6 infection 21.56 10.03 11 823173 6570 109759545
Subarachnoid haemorrhage 21.53 10.03 131 823053 29571 109736544
Hyperprolactinaemia 21.52 10.03 11 823173 6564 109759551
Hypertriglyceridaemia 21.45 10.03 56 823128 16098 109750017
Postoperative wound infection 21.44 10.03 195 822989 15558 109750557
Atrioventricular block complete 21.41 10.03 77 823107 20005 109746110
Amyloid arthropathy 21.39 10.03 42 823142 1638 109764477
Visual acuity reduced 21.24 10.03 146 823038 32027 109734088
Nasal oedema 21.21 10.03 104 823080 6735 109759380
Thrombosis 21.18 10.03 631 822553 108031 109658084
Adverse drug reaction 21.18 10.03 975 822209 104584 109661531
Epistaxis 21.18 10.03 775 822409 129597 109636518
Arterial occlusive disease 21.16 10.03 52 823132 15256 109750859
Nail operation 21.15 10.03 42 823142 1652 109764463
Acute myeloid leukaemia recurrent 21.14 10.03 6 823178 5133 109760982
Schizophrenia 21.13 10.03 87 823097 21739 109744376
Fracture delayed union 21.07 10.03 49 823135 2152 109763963
Anti-neutrophil cytoplasmic antibody positive vasculitis 21.07 10.03 7 823177 5410 109760705
Bacterial sepsis 21.06 10.03 28 823156 10398 109755717
Pulmonary hypertension 20.96 10.03 287 822897 54933 109711182
Ultrasound antenatal screen 20.83 10.03 26 823158 680 109765435
Sleep disorder due to a general medical condition 20.81 10.03 268 822916 51844 109714271
Presyncope 20.81 10.03 248 822936 48639 109717476
Skin papilloma 20.77 10.03 104 823080 6792 109759323
Renal tubular necrosis 20.76 10.03 137 823047 30338 109735777
Type 1 diabetes mellitus 20.73 10.03 22 823162 9025 109757090
Troponin increased 20.69 10.03 133 823051 29633 109736482
Spondylitis 20.67 10.03 150 823034 11188 109754927
Female genital tract fistula 20.64 10.03 59 823125 16460 109749655
COVID-19 pneumonia 20.55 10.03 177 823007 36966 109729149
Breast cancer stage I 20.50 10.03 15 823169 7372 109758743
Ventricular arrhythmia 20.47 10.03 27 823157 10060 109756055
Mucocutaneous ulceration 20.44 10.03 27 823157 748 109765367
Cyst 20.36 10.03 200 822984 16296 109749819
Dyspnoea exertional 20.36 10.03 604 822580 103456 109662659
Human antichimeric antibody positive 20.33 10.03 42 823142 1700 109764415
Hyperlactacidaemia 20.31 10.03 19 823165 8267 109757848
Product label confusion 20.26 10.03 258 822926 22419 109743696
Venoocclusive disease 20.23 10.03 11 823173 6339 109759776
Amylase increased 20.22 10.03 39 823145 12480 109753635
Walking aid user 20.21 10.03 280 822904 24795 109741320
Dysgeusia 20.14 10.03 383 822801 69602 109696513
Hyperphosphataemia 20.11 10.03 59 823125 16322 109749793
Therapy non-responder 20.04 10.03 1394 821790 155913 109610202
Bradypnoea 19.86 10.03 21 823163 8628 109757487
Ulcer haemorrhage 19.83 10.03 256 822928 22315 109743800
Vertigo 19.64 10.03 494 822690 86376 109679739
Lipase increased 19.63 10.03 72 823112 18600 109747515
Full blood count abnormal 19.63 10.03 296 822888 55756 109710359
Bronchitis 19.56 10.03 1389 821795 155643 109610472
Osteopenia 19.56 10.03 252 822932 21957 109744158
Complications of transplanted kidney 19.53 10.03 16 823168 7426 109758689
Hyperammonaemia 19.49 10.03 46 823138 13686 109752429
Oesophageal carcinoma 19.41 10.03 35 823149 11489 109754626
Prostatic specific antigen increased 19.33 10.03 40 823144 12471 109753644
Metastases to lymph nodes 19.29 10.03 53 823131 14979 109751136
Vitamin B6 deficiency 19.29 10.03 23 823161 573 109765542
Vascular device infection 19.18 10.03 61 823123 16451 109749664
Foot operation 19.08 10.03 106 823078 7207 109758908
Ventricular extrasystoles 19.08 10.03 95 823089 22546 109743569
Systemic inflammatory response syndrome 19.07 10.03 43 823141 13000 109753115
Metastasis 19.06 10.03 20 823164 8247 109757868
Total lung capacity decreased 19.03 10.03 15 823169 7099 109759016
Immune-mediated enterocolitis 18.95 10.03 29 823155 10156 109755959
Varicella zoster virus infection 18.92 10.03 12 823172 6356 109759759
Disturbance in social behaviour 18.87 10.03 7 823177 5051 109761064
Weight decreased 18.86 10.03 3852 819332 464205 109301910
Hypomagnesaemia 18.75 10.03 326 822858 60044 109706071
Joint noise 18.75 10.03 82 823102 5061 109761054
Short stature 18.73 10.03 31 823153 1056 109765059
Skin burning sensation 18.72 10.03 91 823093 21734 109744381
Blood pressure increased 18.67 10.03 2197 820987 256176 109509939
Hypoxic-ischaemic encephalopathy 18.66 10.03 23 823161 8824 109757291
Hypernatraemia 18.60 10.03 69 823115 17764 109748351
Lymphatic fistula 18.58 10.03 37 823147 1458 109764657
Ingrown hair 18.58 10.03 26 823158 762 109765353
Osteonecrosis 18.57 10.03 161 823023 33580 109732535
Dyspepsia 18.55 10.03 1657 821527 189308 109576807
Trisomy 18 18.53 10.03 23 823161 598 109765517
Pulmonary function test abnormal 18.52 10.03 7 823177 4993 109761122
Ketoacidosis 18.50 10.03 29 823155 10058 109756057
Salivary hypersecretion 18.44 10.03 67 823117 17354 109748761
International normalised ratio increased 18.41 10.03 498 822686 86274 109679841
Psychiatric decompensation 18.35 10.03 10 823174 5755 109760360
Femoral hernia incarcerated 18.34 10.03 37 823147 1472 109764643
Colitis ulcerative 18.31 10.03 727 822457 76636 109689479
Breast cancer stage II 18.29 10.03 296 822888 27079 109739036
Macular degeneration 18.18 10.03 91 823093 21568 109744547
Wound infection pseudomonas 18.16 10.03 49 823135 2362 109763753
Maternal exposure during breast feeding 18.14 10.03 71 823113 4167 109761948
Fear of injection 18.07 10.03 121 823063 8790 109757325
Cryptococcosis 17.98 10.03 6 823178 4625 109761490
Bradykinesia 17.96 10.03 33 823151 10755 109755360
Product prescribing issue 17.96 10.03 43 823141 12729 109753386
Eosinophil count increased 17.95 10.03 88 823096 20970 109745145
Concomitant disease aggravated 17.94 10.03 62 823122 16302 109749813
Anhedonia 17.91 10.03 57 823127 15371 109750744
Syringe issue 17.84 10.03 27 823157 9498 109756617
Foetal exposure during pregnancy 17.76 10.03 106 823078 7399 109758716
Intracranial pressure increased 17.74 10.03 32 823152 10503 109755612
Type I hypersensitivity 17.72 10.03 13 823171 6380 109759735
Depressive symptom 17.62 10.03 22 823162 8392 109757723
Anticholinergic syndrome 17.60 10.03 5 823179 4275 109761840
Purpura 17.45 10.03 108 823076 24280 109741835
Creatinine renal clearance increased 17.39 10.03 3 823181 3622 109762493
Body height below normal 17.39 10.03 44 823140 2040 109764075
Sputum discoloured 17.38 10.03 129 823055 27816 109738299
Polyhydramnios 17.38 10.03 42 823142 1891 109764224
Hallucination, auditory 17.32 10.03 120 823064 26277 109739838
Temperature intolerance 17.30 10.03 50 823134 13900 109752215
Breast feeding 17.29 10.03 24 823160 698 109765417
Cross sensitivity reaction 17.22 10.03 10 823174 5557 109760558
Circulatory collapse 17.21 10.03 221 822963 42772 109723343
Malignant melanoma 17.20 10.03 197 822987 16694 109749421
Atrioventricular block 17.15 10.03 66 823118 16811 109749304
Personality change 17.14 10.03 35 823149 10967 109755148
Hyperthermia malignant 17.10 10.03 4 823180 3896 109762219
Hypotonia 17.03 10.03 60 823124 15685 109750430
Device occlusion 17.01 10.03 57 823127 15128 109750987
Acute pulmonary oedema 16.93 10.03 67 823117 16929 109749186
Hypertensive crisis 16.89 10.03 109 823075 24263 109741852
Vascular stent thrombosis 16.86 10.03 5 823179 4156 109761959
Dysphonia 16.84 10.03 433 822751 75496 109690619
Blood prolactin abnormal 16.69 10.03 4 823180 3831 109762284
Hypocalcaemia 16.65 10.03 365 822819 65001 109701114
Lethargy 16.64 10.03 550 822634 93026 109673089
Colitis microscopic 16.62 10.03 48 823136 13346 109752769
Skin cancer 16.60 10.03 204 822980 17580 109748535
Blood glucose decreased 16.54 10.03 140 823044 29348 109736767
Laryngospasm 16.53 10.03 7 823177 4661 109761454
Cholangitis 16.52 10.03 64 823120 16271 109749844
Incorrect dose administered 16.41 10.03 618 822566 103023 109663092
Capillary leak syndrome 16.38 10.03 8 823176 4900 109761215
Post procedural infection 16.36 10.03 166 823018 13643 109752472
Infection reactivation 16.36 10.03 5 823179 4076 109762039
Brain natriuretic peptide increased 16.35 10.03 37 823147 11172 109754943
Post-traumatic stress disorder 16.31 10.03 15 823169 6581 109759534
Genital haemorrhage 16.21 10.03 18 823166 7234 109758881
Hydrocephalus 16.17 10.03 33 823151 10342 109755773
Erectile dysfunction 16.13 10.03 77 823107 18479 109747636
Ileus paralytic 16.12 10.03 40 823144 11697 109754418
Placental disorder 16.11 10.03 28 823156 993 109765122
Total lung capacity increased 16.08 10.03 9 823175 5103 109761012
Deep vein thrombosis 16.05 10.03 864 822320 139023 109627092
Activated partial thromboplastin time prolonged 16.04 10.03 99 823085 22269 109743846
Gait disturbance 15.97 10.03 2333 820851 275875 109490240
Injection site warmth 15.97 10.03 199 822985 17206 109748909
Small for dates baby 15.84 10.03 22 823162 640 109765475
Intraocular pressure increased 15.78 10.03 36 823148 10840 109755275
Epstein-Barr virus associated lymphoproliferative disorder 15.77 10.03 8 823176 4794 109761321
Immune-mediated hepatitis 15.74 10.03 16 823168 6695 109759420
Oropharyngeal pain 15.73 10.03 1190 821994 134086 109632029
Abdominal pain upper 15.70 10.03 2889 820295 346222 109419893
Injection site bruising 15.67 10.03 496 822688 50767 109715348
Pseudomonal sepsis 15.66 10.03 27 823157 9019 109757096
Antibody test positive 15.64 10.03 55 823129 3065 109763050
Lower respiratory tract congestion 15.64 10.03 74 823110 4722 109761393
Mood altered 15.64 10.03 94 823090 21281 109744834
Pulmonary pain 15.62 10.03 90 823094 6203 109759912
Cardiac septal defect 15.61 10.03 27 823157 954 109765161
Jaundice 15.60 10.03 329 822855 58907 109707208
Cough 15.57 10.03 3115 820069 458526 109307589
Gastric cancer 15.52 10.03 37 823147 10971 109755144
Extra dose administered 15.51 10.03 43 823141 12116 109753999
Congestive cardiomyopathy 15.50 10.03 54 823130 14165 109751950
Hyperthyroidism 15.50 10.03 141 823043 29120 109736995
Hepatitis B 15.47 10.03 30 823154 9582 109756533
Steroid diabetes 15.47 10.03 10 823174 5244 109760871
Accidental overdose 15.43 10.03 282 822902 51552 109714563
Drug screen positive 15.36 10.03 15 823169 6395 109759720
Incoherent 15.35 10.03 24 823160 8334 109757781
Neoplasm recurrence 15.35 10.03 10 823174 5222 109760893
Eczema 15.31 10.03 415 822769 71878 109694237
Eyelid oedema 15.30 10.03 60 823124 15202 109750913
Methaemoglobinaemia 15.30 10.03 28 823156 9140 109756975
Tetany 15.22 10.03 4 823180 3600 109762515
Plasma cell myeloma recurrent 15.18 10.03 18 823166 7024 109759091
Multiple allergies 15.17 10.03 44 823140 12219 109753896
Alcoholic liver disease 15.17 10.03 20 823164 553 109765562
Vaginal discharge 15.17 10.03 75 823109 17833 109748282
Benign ovarian tumour 15.11 10.03 18 823166 448 109765667
Delusion 15.09 10.03 109 823075 23646 109742469
Metabolic disorder 15.08 10.03 35 823149 10475 109755640
Bradyarrhythmia 15.07 10.03 9 823175 4925 109761190
Epstein-Barr viraemia 15.06 10.03 4 823180 3575 109762540
Staphylococcal infection 14.95 10.03 401 822783 69543 109696572
Diaphragmatic disorder 14.89 10.03 39 823145 1847 109764268
Heparin-induced thrombocytopenia 14.87 10.03 40 823144 11384 109754731
Porphyria acute 14.85 10.03 209 822975 18571 109747544
Therapeutic response decreased 14.82 10.03 869 822315 95630 109670485
Stillbirth 14.80 10.03 67 823117 4197 109761918
Foetal distress syndrome 14.74 10.03 21 823163 626 109765489
Bronchopulmonary aspergillosis allergic 14.73 10.03 25 823159 8401 109757714
Complication of device removal 14.72 10.03 8 823176 4612 109761503
Pericardial effusion 14.71 10.03 319 822865 56898 109709217
Endodontic procedure 14.63 10.03 54 823130 3082 109763033
Iritis 14.61 10.03 71 823113 4581 109761534
Accidental exposure to product by child 14.59 10.03 3 823181 3195 109762920
Renal cancer 14.55 10.03 49 823135 12985 109753130
Hand fracture 14.54 10.03 107 823077 8015 109758100
Spinal osteoarthritis 14.54 10.03 221 822963 19962 109746153
Asthenia 14.50 10.03 4749 818435 684250 109081865
Device loosening 14.49 10.03 24 823160 818 109765297
Systemic candida 14.49 10.03 33 823151 9941 109756174
Injection site rash 14.47 10.03 250 822934 23169 109742946
Hypervolaemia 14.44 10.03 270 822914 49190 109716925
Haematocrit decreased 14.43 10.03 616 822568 65501 109700614
Mucosal inflammation 14.40 10.03 577 822607 95564 109670551
Immune thrombocytopenia 14.39 10.03 103 823081 22391 109743724
Radiation inflammation 14.32 10.03 27 823157 1021 109765094
Pharyngeal swelling 14.29 10.03 44 823140 11988 109754127
Nervous system disorder 14.25 10.03 159 823025 31562 109734553
Haemoglobin decreased 14.18 10.03 2085 821099 246642 109519473
Pain of skin 14.18 10.03 89 823095 19940 109746175
Bone marrow failure 14.17 10.03 325 822859 57523 109708592
Delayed graft function 14.12 10.03 7 823177 4250 109761865
Nephrotic syndrome 14.11 10.03 54 823130 13777 109752338
Reversible cerebral vasoconstriction syndrome 14.10 10.03 9 823175 4752 109761363
Extravascular haemolysis 14.09 10.03 17 823167 429 109765686
Bone density increased 14.06 10.03 26 823158 969 109765146
Bone density abnormal 14.05 10.03 62 823122 3841 109762274
Kounis syndrome 14.04 10.03 14 823170 5911 109760204
Encephalitis toxic 14.01 10.03 14 823170 284 109765831
Granulocyte count decreased 14.01 10.03 6 823178 3968 109762147
Therapy interrupted 13.93 10.03 274 822910 49548 109716567
Sickle cell anaemia 13.89 10.03 23 823161 784 109765331
Complication of device insertion 13.87 10.03 28 823156 8810 109757305
Tardive dyskinesia 13.86 10.03 53 823131 13526 109752589
Anal fissure 13.80 10.03 123 823061 9758 109756357
Wrong product administered 13.80 10.03 39 823145 10921 109755194
Lip oedema 13.79 10.03 22 823162 7578 109758537
Abortion incomplete 13.77 10.03 3 823181 3069 109763046
Nail injury 13.76 10.03 23 823161 790 109765325
Herpes zoster 13.73 10.03 960 822224 107419 109658696
Placental insufficiency 13.72 10.03 30 823154 1264 109764851
Pancreatic steatosis 13.70 10.03 37 823147 1785 109764330
Haemorrhage in pregnancy 13.69 10.03 35 823149 1633 109764482
Decreased gait velocity 13.68 10.03 12 823172 205 109765910
Sudden death 13.61 10.03 116 823068 24279 109741836
Bone cyst 13.56 10.03 58 823126 3545 109762570
Polyuria 13.51 10.03 77 823107 17661 109748454
Long QT syndrome 13.50 10.03 20 823164 7098 109759017
Liver abscess 13.49 10.03 23 823161 7716 109758399
Hyperventilation 13.49 10.03 29 823155 8918 109757197
Product dose omission in error 13.47 10.03 111 823073 23401 109742714
Cirrhosis alcoholic 13.42 10.03 27 823157 1072 109765043
Linear IgA disease 13.41 10.03 8 823176 4381 109761734
Wrong patient received product 13.41 10.03 18 823166 6656 109759459
Heart rate irregular 13.36 10.03 342 822842 33932 109732183
Catarrh 13.35 10.03 97 823087 7238 109758877
Central nervous system mass 13.33 10.03 23 823161 811 109765304
Sneezing 13.33 10.03 163 823021 31821 109734294
Hepatocellular carcinoma 13.31 10.03 34 823150 9846 109756269
Arteriospasm coronary 13.31 10.03 30 823154 9070 109757045
Dust allergy 13.30 10.03 15 823169 5986 109760129
Atrial flutter 13.25 10.03 116 823068 24146 109741969
Cytomegalovirus colitis 13.24 10.03 20 823164 7041 109759074
Sleep disorder therapy 13.21 10.03 22 823162 7449 109758666
Hypoventilation 13.20 10.03 25 823159 8056 109758059
Hypoglycaemic coma 13.20 10.03 13 823171 5520 109760595
Wall motion score index abnormal 13.19 10.03 23 823161 818 109765297
Swollen joint count 13.17 10.03 110 823074 8564 109757551
Breast cancer female 13.16 10.03 48 823136 12420 109753695
Enterococcal infection 13.16 10.03 93 823091 20273 109745842
Behaviour disorder 13.15 10.03 33 823151 9614 109756501
Vitamin D decreased 13.14 10.03 144 823040 12071 109754044
Epstein-Barr virus infection reactivation 13.12 10.03 7 823177 4077 109762038
Lacrimal disorder 13.11 10.03 18 823166 518 109765597
Hepatic cancer 13.11 10.03 41 823143 11115 109755000
Pseudomembranous colitis 13.08 10.03 17 823167 6374 109759741
Mycotic allergy 13.07 10.03 15 823169 5939 109760176
Lymph gland infection 13.06 10.03 20 823164 637 109765478
Blood folate increased 13.03 10.03 19 823165 579 109765536
Cushingoid 13.03 10.03 139 823045 11573 109754542
Left ventricular dysfunction 12.97 10.03 112 823072 23381 109742734
Ligament rupture 12.97 10.03 62 823122 3973 109762142
Crying 12.93 10.03 125 823059 25503 109740612
Fanconi syndrome 12.91 10.03 5 823179 3514 109762601
Leukoencephalopathy 12.89 10.03 31 823153 9164 109756951
Tumour haemorrhage 12.89 10.03 12 823172 5233 109760882
Infusion site reaction 12.88 10.03 194 822990 17488 109748627
Hypertonia 12.88 10.03 27 823157 8379 109757736
Brain abscess 12.88 10.03 19 823165 6755 109759360
Peritoneal dialysis complication 12.87 10.03 45 823139 2501 109763614
Pulmonary vasculitis 12.87 10.03 18 823166 6542 109759573
Electrocardiogram T wave alternans 12.86 10.03 10 823174 143 109765972
Areflexia 12.86 10.03 19 823165 6750 109759365
Cervical incompetence 12.83 10.03 18 823166 529 109765586
Induced labour 12.82 10.03 24 823160 903 109765212
Vascular purpura 12.81 10.03 6 823178 3765 109762350
Nervousness 12.77 10.03 195 822989 36656 109729459
Pancreatic carcinoma 12.76 10.03 62 823122 14810 109751305
Mitral valve incompetence 12.73 10.03 173 823011 33156 109732959
Spinal cord compression 12.66 10.03 23 823161 7529 109758586
Drooling 12.64 10.03 21 823163 7118 109758997
Conjunctivitis allergic 12.64 10.03 20 823164 6911 109759204
Vein disorder 12.63 10.03 85 823099 6185 109759930
Skin weeping 12.60 10.03 6 823178 3729 109762386
Product monitoring error 12.59 10.03 30 823154 8897 109757218
Immunisation 12.58 10.03 4 823180 3179 109762936
Retinal haemorrhage 12.57 10.03 33 823151 9468 109756647
Ear pain 12.55 10.03 500 822684 52726 109713389
Parvovirus B19 infection 12.55 10.03 3 823181 2878 109763237
Autoimmune hepatitis 12.54 10.03 62 823122 14742 109751373
Myoglobin blood increased 12.54 10.03 8 823176 4224 109761891
Infusion site pain 12.54 10.03 77 823107 17342 109748773
Cyst rupture 12.53 10.03 23 823161 852 109765263
Corneal oedema 12.52 10.03 4 823180 3169 109762946
Head injury 12.51 10.03 235 822949 42782 109723333
Electrolyte imbalance 12.47 10.03 197 822987 36831 109729284
Deformity 12.45 10.03 123 823061 10037 109756078
Hallucinations, mixed 12.43 10.03 29 823155 8664 109757451
Acute lung injury 12.38 10.03 4 823180 3147 109762968
Productive cough 12.37 10.03 710 822474 113595 109652520
Enterobacter infection 12.37 10.03 15 823169 5796 109760319
Hypothalamo-pituitary disorder 12.32 10.03 3 823181 2843 109763272
Taste disorder 12.27 10.03 600 822584 64787 109701328
Laryngeal oedema 12.27 10.03 35 823149 9772 109756343
Panic attack 12.25 10.03 147 823037 28793 109737322
Injection site swelling 12.24 10.03 570 822614 61220 109704895
Autonomic nervous system imbalance 12.22 10.03 15 823169 5765 109760350
Aspiration 12.20 10.03 157 823027 30376 109735739
Joint lock 12.17 10.03 56 823128 3532 109762583
Muscle spasticity 12.12 10.03 191 822993 35724 109730391
Neutrophilia 12.11 10.03 38 823146 10291 109755824
Device breakage 12.05 10.03 57 823127 13712 109752403
Extradural haematoma 12.02 10.03 5 823179 3364 109762751
Injection site extravasation 11.93 10.03 122 823062 10047 109756068
Transient aphasia 11.92 10.03 20 823164 689 109765426
Human anti-human antibody test 11.91 10.03 15 823169 396 109765719
Spirometry abnormal 11.90 10.03 14 823170 5483 109760632
Staphylococcal bacteraemia 11.89 10.03 74 823110 16614 109749501
Anaesthetic complication 11.85 10.03 6 823178 3600 109762515
Dermatitis bullous 11.84 10.03 79 823105 17450 109748665
Inflammatory marker increased 11.84 10.03 162 823022 14307 109751808
Defaecation disorder 11.84 10.03 22 823162 823 109765292
Mycobacterium chelonae infection 11.82 10.03 4 823180 3056 109763059
Pneumomediastinum 11.82 10.03 12 823172 5024 109761091
Lymphoedema 11.81 10.03 64 823120 14865 109751250
Aortic arteriosclerosis 11.79 10.03 129 823055 10809 109755306
Oligoarthritis 11.79 10.03 21 823163 760 109765355
Swelling face 11.78 10.03 564 822620 91757 109674358
Clonus 11.74 10.03 30 823154 8686 109757429
Fibroadenoma of breast 11.72 10.03 20 823164 699 109765416
Tender joint count increased 11.71 10.03 15 823169 403 109765712
Haemorrhagic transformation stroke 11.68 10.03 4 823180 3033 109763082
Dysuria 11.68 10.03 350 822834 59881 109706234
Tooth disorder 11.66 10.03 295 822889 29214 109736901
Fungaemia 11.64 10.03 17 823167 6069 109760046
Hepatitis C 11.63 10.03 51 823133 12522 109753593
Troponin T increased 11.62 10.03 9 823175 4297 109761818
Joint warmth 11.58 10.03 38 823146 2044 109764071
Polydipsia 11.52 10.03 25 823159 7663 109758452
Analgesic therapy 11.50 10.03 23 823161 7261 109758854
Hepatitis E antibody positive 11.49 10.03 12 823172 257 109765858
Paronychia 11.47 10.03 43 823141 11038 109755077
Threatened labour 11.44 10.03 19 823165 649 109765466
Increased appetite 11.42 10.03 65 823119 14912 109751203
Rhinovirus infection 11.41 10.03 47 823137 11742 109754373
Airway remodelling 11.33 10.03 23 823161 919 109765196
Mite allergy 11.31 10.03 16 823168 5787 109760328
Labyrinthitis 11.30 10.03 49 823135 3013 109763102
Mitochondrial toxicity 11.28 10.03 5 823179 3240 109762875
Musculoskeletal disorder 11.27 10.03 234 822950 22430 109743685
Pneumonia fungal 11.27 10.03 64 823120 14690 109751425
Bone fissure 11.24 10.03 18 823166 596 109765519
Hypovolaemia 11.24 10.03 105 823079 21569 109744546
Immune-mediated myocarditis 11.23 10.03 6 823178 3492 109762623
Candida sepsis 11.21 10.03 4 823180 2957 109763158
Embolism 11.21 10.03 73 823111 16216 109749899
Device issue 11.21 10.03 185 822999 34350 109731765
Oesophageal fibrosis 11.16 10.03 10 823174 176 109765939
Angina unstable 11.13 10.03 74 823110 16358 109749757
Insurance issue 11.11 10.03 41 823143 10571 109755544
Carcinoid tumour of the small bowel 11.10 10.03 15 823169 425 109765690
Oral candidiasis 11.09 10.03 251 822933 44509 109721606
C-reactive protein decreased 11.08 10.03 47 823137 2862 109763253
Back pain 11.01 10.03 2519 820665 368477 109397638
Rash morbilliform 11.00 10.03 27 823157 7924 109758191
Red blood cell sedimentation rate decreased 10.96 10.03 28 823156 1306 109764809
Pulmonary nocardiosis 10.94 10.03 3 823181 2626 109763489
Post procedural haemorrhage 10.94 10.03 69 823115 15443 109750672
Plasma cell myeloma 10.93 10.03 371 822813 62565 109703550
Myofascial pain syndrome 10.93 10.03 43 823141 2530 109763585
Inadequate analgesia 10.92 10.03 13 823171 5064 109761051
Tension headache 10.84 10.03 36 823148 9582 109756533
Dactylitis 10.84 10.03 60 823124 4073 109762042
Blood loss anaemia 10.84 10.03 84 823100 17941 109748174
Tumour marker increased 10.84 10.03 13 823171 5047 109761068
Liver transplant rejection 10.82 10.03 8 823176 3910 109762205
Escherichia bacteraemia 10.81 10.03 39 823145 10125 109755990
Erythema of eyelid 10.80 10.03 8 823176 3907 109762208
Unevaluable event 10.79 10.03 347 822837 58880 109707235
Urinary incontinence 10.79 10.03 277 822907 48310 109717805
Nightmare 10.78 10.03 214 822970 38649 109727466
Anger 10.77 10.03 90 823094 18917 109747198
Hydronephrosis 10.76 10.03 100 823084 20565 109745550
Chronic obstructive pulmonary disease 10.76 10.03 684 822500 108474 109657641
Coeliac disease 10.73 10.03 408 822776 42779 109723336
Neurological symptom 10.72 10.03 70 823114 15538 109750577
Tooth abscess 10.69 10.03 198 822986 18591 109747524
Propofol infusion syndrome 10.69 10.03 3 823181 2586 109763529
Persecutory delusion 10.69 10.03 19 823165 6272 109759843
Drug therapy 10.69 10.03 24 823160 7267 109758848
Cerebral toxoplasmosis 10.67 10.03 5 823179 3137 109762978
Burns second degree 10.67 10.03 96 823088 7637 109758478
Total lung capacity abnormal 10.66 10.03 11 823173 4572 109761543
Bronchial secretion retention 10.66 10.03 13 823171 5011 109761104
Staphylococcal sepsis 10.65 10.03 81 823103 17373 109748742
Hemianopia 10.65 10.03 4 823180 2864 109763251
Schizoaffective disorder 10.64 10.03 5 823179 3131 109762984
Loss of libido 10.62 10.03 5 823179 3128 109762987
Poor quality device used 10.62 10.03 4 823180 2859 109763256
Pharyngitis streptococcal 10.60 10.03 148 823036 13129 109752986
Osteoporotic fracture 10.54 10.03 72 823112 5265 109760850
Viraemia 10.54 10.03 9 823175 4093 109762022
Functional gastrointestinal disorder 10.52 10.03 18 823166 6031 109760084
Transfusion-related circulatory overload 10.51 10.03 22 823162 899 109765216
Hypochloraemia 10.50 10.03 7 823177 3611 109762504
Coronary artery bypass 10.49 10.03 18 823166 6024 109760091
Drug abuser 10.45 10.03 15 823169 5394 109760721
Swollen tongue 10.45 10.03 356 822828 60006 109706109
Blood uric acid increased 10.44 10.03 106 823078 21423 109744692
Urine ketone body present 10.43 10.03 8 823176 3838 109762277
Vasculitis 10.42 10.03 196 822988 35677 109730438
Abortion threatened 10.41 10.03 15 823169 452 109765663
Skin graft failure 10.41 10.03 11 823173 239 109765876
Hypophagia 10.40 10.03 305 822879 52321 109713794
Accident 10.39 10.03 44 823140 10908 109755207
Necrotising fasciitis 10.32 10.03 26 823158 7565 109758550
Bronchial obstruction 10.31 10.03 5 823179 3074 109763041
Pneumonitis 10.27 10.03 465 822719 76066 109690049
Respiratory tract infection 10.26 10.03 641 822543 70976 109695139
Pallor 10.25 10.03 331 822853 56136 109709979
Cystoid macular oedema 10.24 10.03 4 823180 2796 109763319
Hypovolaemic shock 10.22 10.03 65 823119 14518 109751597
Maternal exposure during delivery 10.21 10.03 7 823177 3558 109762557
Tuberculin test positive 10.13 10.03 54 823130 3614 109762501
Disorganised speech 10.12 10.03 6 823178 3297 109762818
Eosinophilic granulomatosis with polyangiitis 10.09 10.03 43 823141 10643 109755472
Clear cell renal cell carcinoma 10.09 10.03 44 823140 2712 109763403
Pupillary reflex impaired 10.09 10.03 9 823175 4006 109762109
Eyelid ptosis 10.07 10.03 58 823126 13269 109752846
Apraxia 10.07 10.03 7 823177 3533 109762582
Prerenal failure 10.04 10.03 11 823173 4448 109761667

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC A11DA01 ALIMENTARY TRACT AND METABOLISM
VITAMINS
VITAMIN B1, PLAIN AND IN COMBINATION WITH VITAMIN B6 AND B12
Vitamin B1, plain
MeSH PA D014803 Vitamin B Complex
MeSH PA D014815 Vitamins
MeSH PA D018977 Micronutrients
CHEBI has role CHEBI:35554 cardiovascular drug
CHEBI has role CHEBI:71692 insect repellent
CHEBI has role CHEBI:75835 anti-anaemic agent

Related Drugs by ATC class:

A11DA Vitamin B1, plain 2 drugs
benfotiaminesulbutiamine

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Korsakoff's psychosis indication 69482004 DOID:10915
Pernicious anemia indication 84027009 DOID:13381
Vitamin deficiency indication 85670002
Mineral deficiency indication 111379007
Cobalamin deficiency indication 190634004
Thiamin deficiency indication 399357009 DOID:0070313
Vitamin Deficiency Prevention indication
Mineral Deficiency Prevention indication
Prevention of Vitamin B12 Deficiency indication
Methylmalonic acidemia off-label use 42393006
Necrotizing enterocolitis in fetus OR newborn contraindication 2707005
Alcoholism contraindication 7200002
Peptic ulcer contraindication 13200003 DOID:750
Myocardial infarction contraindication 22298006 DOID:5844
Hypertensive disorder contraindication 38341003 DOID:10763
Gastrointestinal ulcer contraindication 40845000
Hypokalemia contraindication 43339004
Conduction disorder of the heart contraindication 44808001
Chronic heart failure contraindication 48447003
Gastrointestinal perforation contraindication 51875005
Gastrectomy contraindication 53442002
Leber's optic atrophy contraindication 58610003 DOID:705
Hepatic failure contraindication 59927004
Blood coagulation disorder contraindication 64779008 DOID:1247
Agoraphobia contraindication 70691001 DOID:593
Gastrointestinal hemorrhage contraindication 74474003
Atrophic gastritis contraindication 84568007 DOID:8929
Kidney disease contraindication 90708001 DOID:557
Hemophilia contraindication 90935002
Seizure disorder contraindication 128613002
Obsessive-compulsive disorder contraindication 191736004 DOID:10933
Insomnia contraindication 193462001
Impaired renal function disorder contraindication 197663003
Coronary artery bypass graft contraindication 232717009
Disease of liver contraindication 235856003 DOID:409
Pregnancy, function contraindication 289908002
Panic disorder contraindication 371631005 DOID:594
Cardiovascular event risk contraindication 395112001
Myocardial ischemia contraindication 414795007 DOID:3393
Myocardial infarction in recovery phase contraindication 418044006
Smokes tobacco daily contraindication 449868002
Acute Thromboembolic Stroke contraindication




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.94 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRouteExclusivity dateDescription
2 IU/ML;40MG/ML;12MCG/ML;40 IU/ML;1MCG/ML;3MG/ML;120MCG/ML;8MG/ML;1.2MG/ML;0.72MG/ML;1.2MG/ML;660 IU/ML;30MCG/ML MULTIPLE VITAMINS INJECTION ADULT APOTEX A210672 April 9, 2026 RX SOLUTION INTRAVENOUS Dec. 1, 2026 COMPETITIVE GENERIC THERAPY
80MG/VIAL;0.02MG/VIAL;400 IU/VIAL;0.001MG/VIAL;5MG/VIAL;0.14MG/VIAL;17MG/VIAL;1MG/VIAL;1.4MG/VIAL;1.2MG/VIAL;7 IU/VIAL;2,300 IU/VIAL;0.2MG/VIAL MULTIPLE VITAMINS INJECTION PEDIATRIC APOTEX A210671 April 21, 2026 RX INJECTABLE INTRAVENOUS Dec. 21, 2026 COMPETITIVE GENERIC THERAPY

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Thiamine transporter 1 Transporter WOMBAT-PK
Transketolase Enzyme WOMBAT-PK
Thiamin pyrophosphokinase 1 Kinase WOMBAT-PK
Thiamine-triphosphatase Enzyme WOMBAT-PK
Transketolase-like protein 1 Enzyme WOMBAT-PK
Heat shock protein HSP 90-alpha Cytosolic other IC50 4.90 CHEMBL
Thiamine transporter ThiT Transporter Kd 9.91 CHEMBL

External reference:

IDSource
4017777 VUID
N0000146138 NUI
D08580 KEGG_DRUG
67-03-8 SECONDARY_CAS_RN
532-43-4 SECONDARY_CAS_RN
4017446 VANDF
4017474 VANDF
4017634 VANDF
4017777 VANDF
4021900 VANDF
C0039840 UMLSCUI
CHEBI:18385 CHEBI
VIB PDB_CHEM_ID
CHEMBL1588 ChEMBL_ID
CHEMBL1200941 ChEMBL_ID
CHEMBL2104496 ChEMBL_ID
DB00152 DRUGBANK_ID
D013831 MESH_DESCRIPTOR_UI
1130 PUBCHEM_CID
4629 IUPHAR_LIGAND_ID
C000712172 MESH_SUPPLEMENTAL_RECORD_UI
432 INN_ID
X66NSO3N35 UNII
10454 RXNORM
1096 MMSL
15466 MMSL
41397 MMSL
5566 MMSL
5681 MMSL
7276 MMSL
d03130 MMSL
001061 NDDF
001062 NDDF
003860 NDDF
126228004 SNOMEDCT_US
126229007 SNOMEDCT_US
259659006 SNOMEDCT_US
30306003 SNOMEDCT_US
X66NSO3N35 INXIGHT DRUGS

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
NataFort HUMAN PRESCRIPTION DRUG LABEL 10 0178-0716 TABLET 2 mg ORAL Unapproved drug other 12 sections
CitraNatal 90 DHA HUMAN PRESCRIPTION DRUG LABEL 16 0178-0821 TABLET 3 mg ORAL unapproved drug other 11 sections
CitraNatal 90 DHA HUMAN PRESCRIPTION DRUG LABEL 16 0178-0821 TABLET 4.54 mg ORAL unapproved drug other 11 sections
CitraNatal 90 DHA HUMAN OTC DRUG LABEL 14 0178-0829 TABLET 3 mg ORAL Unapproved drug other 11 sections
CitraNatal Rx HUMAN PRESCRIPTION DRUG LABEL 13 0178-0858 TABLET 3 mg ORAL Unapproved drug other 12 sections
CitraNatal Rx HUMAN PRESCRIPTION DRUG LABEL 14 0178-0859 TABLET 3 mg ORAL Unapproved drug other 9 sections
CitraNatal DHA HUMAN OTC DRUG LABEL 14 0178-0898 TABLET 3 mg ORAL Unapproved drug other 11 sections
THIAMINE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0404-9799 INJECTION, SOLUTION 100 mg INTRAMUSCULAR ANDA 12 sections
THIAMINE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0404-9799 INJECTION, SOLUTION 100 mg INTRAMUSCULAR ANDA 12 sections
THIAMINE HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 0404-9963 INJECTION, SOLUTION 100 mg INTRAMUSCULAR ANDA 11 sections
Thiamine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0641-6228 INJECTION, SOLUTION 100 mg INTRAMUSCULAR ANDA 15 sections
VitafolOne HUMAN PRESCRIPTION DRUG LABEL 16 0642-0070 CAPSULE, GELATIN COATED 1.60 mg ORAL unapproved drug other 14 sections
Select OB HUMAN PRESCRIPTION DRUG LABEL 15 0642-0077 TABLET, CHEWABLE 1.60 mg ORAL UNAPPROVED DRUG OTHER 14 sections
Vitafol OBCaplet HUMAN PRESCRIPTION DRUG LABEL 15 0642-0079 TABLET 1.60 mg ORAL unapproved drug other 14 sections
Vitafol Plus HUMAN PRESCRIPTION DRUG LABEL 17 0642-0092 CAPSULE, LIQUID FILLED 1.60 mg ORAL UNAPPROVED DRUG OTHER 13 sections
VitafolUltra HUMAN PRESCRIPTION DRUG LABEL 17 0642-0093 CAPSULE, LIQUID FILLED 1.60 mg ORAL unapproved drug other 13 sections
Select OB HUMAN PRESCRIPTION DRUG LABEL 15 0642-0120 TABLET, CHEWABLE 1.60 mg ORAL UNAPPROVED DRUG OTHER 13 sections
Strovite OneCaplets HUMAN PRESCRIPTION DRUG LABEL 20 0642-0207 TABLET 20 mg ORAL unapproved drug other 14 sections
Reaphirm Plant Source DHA HUMAN PRESCRIPTION DRUG LABEL 16 0642-3010 CAPSULE, GELATIN COATED 1.60 mg ORAL unapproved drug other 7 sections
Vitafol Fe Plus HUMAN PRESCRIPTION DRUG LABEL 17 0642-7473 CAPSULE, LIQUID FILLED 1.60 mg ORAL unapproved drug other 14 sections
Marnatal F HUMAN PRESCRIPTION DRUG LABEL 13 0682-1570 CAPSULE 3 mg ORAL UNAPPROVED DRUG OTHER 4 sections
BACMIN HUMAN PRESCRIPTION DRUG LABEL 19 0682-3001 TABLET, COATED 20 mg ORAL UNAPPROVED DRUG OTHER 10 sections
O-Cal Prenatal Vitamin HUMAN PRESCRIPTION DRUG LABEL 16 0813-0202 TABLET 1.50 mg ORAL UNAPPROVED DRUG OTHER 6 sections
Dialyvite Supreme D HUMAN PRESCRIPTION DRUG LABEL 13 10542-009 TABLET, COATED 1.50 mg ORAL Unapproved drug other 7 sections
Dialyvite HUMAN PRESCRIPTION DRUG LABEL 9 10542-010 TABLET, COATED 1.50 mg ORAL Unapproved drug other 7 sections
Dialyvite 5000 HUMAN PRESCRIPTION DRUG LABEL 12 10542-011 TABLET, COATED 1.50 mg ORAL Unapproved drug other 7 sections
Dialyvite with Zinc HUMAN PRESCRIPTION DRUG LABEL 10 10542-012 TABLET, COATED 1.50 mg ORAL Unapproved drug other 7 sections
Dialyvite 3000 HUMAN PRESCRIPTION DRUG LABEL 12 10542-014 TABLET, COATED 1.50 mg ORAL Unapproved drug other 7 sections
PRENATAL PLUS HUMAN PRESCRIPTION DRUG LABEL 15 10544-549 TABLET, FILM COATED 1.84 mg ORAL unapproved drug other 8 sections
PRENATAL PLUS IRON HUMAN PRESCRIPTION DRUG LABEL 15 10544-609 TABLET, FILM COATED 1.84 mg ORAL UNAPPROVED DRUG OTHER 7 sections