thiamine Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
2832 59-43-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • thiamine
  • vitamin B1
  • thiamine hydrochloride
  • thiamine mononitrate
  • thiamine (vit B1)
  • thiamine HCl
3-((4-Amino-2-methyl-5-pyrimidinyl)methyl)-5-(2- hydroxyethyl)-4-methylthiazolium chloride.
  • Molecular weight: 265.35
  • Formula: C12H17N4OS
  • CLOGP: -4.56
  • LIPINSKI: 0
  • HAC: 5
  • HDO: 2
  • TPSA: 75.91
  • ALOGS: -4.29
  • ROTB: 4

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
50 mg O
50 mg P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 27 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 90 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 5.55 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 4.50 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

DateAgencyCompanyOrphan
Dec. 29, 1993 FDA HOSPIRA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Rheumatoid arthritis 988.54 9.92 3712 311772 236503 46134075
Pemphigus 855.11 9.92 1277 314207 43997 46326581
Systemic lupus erythematosus 726.94 9.92 1456 314028 63724 46306854
Completed suicide 703.92 9.92 81 315403 145839 46224739
Glossodynia 567.92 9.92 1051 314433 43322 46327256
Toxicity to various agents 432.53 9.92 476 315008 211290 46159288
Hand deformity 418.82 9.92 800 314684 33774 46336804
Maternal exposure during pregnancy 397.58 9.92 1557 313927 100992 46269586
Alopecia 367.01 9.92 2108 313376 160306 46210272
Arthropathy 347.09 9.92 1309 314175 83391 46287187
Abdominal discomfort 331.06 9.92 1946 313538 149219 46221359
Joint swelling 315.45 9.92 2061 313423 164012 46206566
Death 311.48 9.92 1191 314293 334357 46036221
Drug abuse 308.58 9.92 34 315450 63374 46307204
Pain 301.48 9.92 4705 310779 472243 45898335
Infusion related reaction 293.45 9.92 1408 314076 99800 46270778
Arthralgia 273.63 9.92 3707 311777 360896 46009682
Wound 259.94 9.92 756 314728 42046 46328532
Exposure during pregnancy 248.43 9.92 1411 314073 106801 46263777
Intentional overdose 248.05 9.92 66 315418 64878 46305700
Drug interaction 238.97 9.92 648 314836 202446 46168132
Synovitis 216.33 9.92 902 314582 60173 46310405
Anti-cyclic citrullinated peptide antibody positive 199.38 9.92 416 315068 18729 46351849
Contraindicated product administered 192.42 9.92 1056 314428 78891 46291687
Nasopharyngitis 187.16 9.92 1723 313761 152275 46218303
Drug hypersensitivity 185.44 9.92 932 314552 242893 46127685
Overdose 183.92 9.92 252 315232 101727 46268851
Pericarditis 176.55 9.92 454 315030 23473 46347105
Swelling 172.51 9.92 1434 314050 123077 46247501
Rheumatoid factor positive 169.71 9.92 406 315078 20055 46350523
Febrile neutropenia 156.79 9.92 248 315236 94379 46276199
Hip arthroplasty 156.31 9.92 365 315119 17747 46352831
Suicide attempt 150.13 9.92 93 315391 54943 46315635
Red blood cell sedimentation rate abnormal 140.28 9.92 295 315189 13354 46357224
Musculoskeletal stiffness 139.66 9.92 1136 314348 96857 46273721
Knee arthroplasty 138.87 9.92 413 315071 23252 46347326
Product use issue 136.41 9.92 1100 314384 93544 46277034
Acute kidney injury 135.86 9.92 984 314500 234871 46135707
Injection site erythema 134.00 9.92 912 314572 73515 46297063
C-reactive protein abnormal 132.29 9.92 379 315105 20891 46349687
Cardiac arrest 129.83 9.92 259 315225 90140 46280438
Sickle cell anaemia with crisis 120.84 9.92 142 315342 3850 46366728
Discomfort 117.34 9.92 624 314860 46046 46324532
Device expulsion 115.07 9.92 23 315461 27519 46343059
Pregnancy 112.35 9.92 421 315063 26716 46343862
Injection site pain 112.00 9.92 1162 314322 105990 46264588
Depressed level of consciousness 103.60 9.92 101 315383 47468 46323110
Malignant neoplasm progression 103.01 9.92 175 315309 64751 46305827
Injection site pruritus 100.32 9.92 532 314952 39211 46331367
Lactic acidosis 97.14 9.92 54 315430 33855 46336723
Blood pressure fluctuation 94.27 9.92 432 315052 30016 46340562
Injection site reaction 91.32 9.92 595 314889 47254 46323324
Cardiac failure 90.96 9.92 259 315225 79689 46290889
Arthritis 90.25 9.92 858 314626 76458 46294120
Bradycardia 90.08 9.92 196 315288 66102 46304476
Injection site swelling 88.61 9.92 520 314964 39807 46330771
Respiratory arrest 88.32 9.92 60 315424 33756 46336822
Psoriatic arthropathy 87.10 9.92 480 315004 35899 46334679
Therapeutic product effect decreased 86.88 9.92 897 314587 81704 46288874
Abortion spontaneous 83.45 9.92 543 314941 43103 46327475
Sopor 81.91 9.92 17 315467 19811 46350767
Osteoarthritis 79.83 9.92 703 314781 61322 46309256
Drug reaction with eosinophilia and systemic symptoms 79.10 9.92 51 315433 29497 46341081
Disease progression 78.74 9.92 333 315151 90967 46279611
Cardio-respiratory arrest 76.47 9.92 183 315301 59686 46310892
Intentional self-injury 74.42 9.92 35 315449 24131 46346447
Basal cell carcinoma 74.39 9.92 305 315179 20182 46350396
Product quality issue 73.86 9.92 79 315405 35569 46335009
Duodenal ulcer perforation 71.90 9.92 170 315314 8332 46362246
Rhabdomyolysis 70.18 9.92 109 315375 41800 46328778
Dyspnoea 69.91 9.92 2813 312671 512735 45857843
Renal failure 69.68 9.92 465 315019 113129 46257449
Helicobacter infection 68.07 9.92 204 315280 11532 46359046
Neutropenia 67.92 9.92 629 314855 142575 46228003
Caesarean section 66.59 9.92 255 315229 16348 46354230
Hyponatraemia 65.62 9.92 408 315076 100924 46269654
Hypotension 64.96 9.92 1143 314341 231446 46139132
Anxiety 64.89 9.92 853 314631 181104 46189474
Sinusitis 64.66 9.92 1234 314250 128534 46242044
Disability assessment scale score increased 63.62 9.92 77 315407 2155 46368423
Joint effusion 62.62 9.92 201 315283 11794 46358784
Tremor 61.94 9.92 492 314992 115147 46255431
Agitation 61.94 9.92 181 315303 55234 46315344
Psoriasis 61.81 9.92 807 314677 77797 46292781
Fatigue 57.82 9.92 4817 310667 603880 45766698
Drug ineffective 57.59 9.92 5320 310164 672518 45698060
Asthma 57.51 9.92 372 315112 91170 46279408
Impaired healing 55.60 9.92 432 315052 36311 46334267
Joint laxity 54.42 9.92 69 315415 2027 46368551
Injection site bruising 53.93 9.92 419 315065 35217 46335361
Sedation 53.01 9.92 46 315438 22864 46347714
Premature labour 52.46 9.92 182 315302 11117 46359461
Treatment failure 52.26 9.92 902 314582 92185 46278393
Drug withdrawal syndrome 52.07 9.92 65 315419 27319 46343259
Electrocardiogram QT prolonged 51.49 9.92 176 315308 51149 46319429
Osteoporosis 51.07 9.92 458 315026 40150 46330428
Cholestasis 50.96 9.92 64 315420 26829 46343749
Tachycardia 50.54 9.92 430 315054 99192 46271386
Confusional state 50.46 9.92 768 314716 159124 46211454
Lower respiratory tract infection 50.41 9.92 582 314902 54507 46316071
Live birth 50.25 9.92 169 315315 10161 46360417
Pulmonary arterial hypertension 49.87 9.92 61 315423 25867 46344711
Localised infection 49.77 9.92 303 315181 23498 46347080
Drug dependence 49.75 9.92 37 315447 19864 46350714
Constipation 48.74 9.92 855 314629 173242 46197336
Oropharyngeal pain 48.08 9.92 736 314748 73432 46297146
Blood pressure diastolic abnormal 48.05 9.92 121 315363 6173 46364405
Hypoglycaemia 46.98 9.92 198 315286 54151 46316427
Poisoning 46.71 9.92 18 315466 13976 46356602
Red blood cell sedimentation rate increased 46.36 9.92 289 315195 22600 46347978
Serotonin syndrome 45.52 9.92 58 315426 24162 46346416
Nausea 45.36 9.92 4016 311468 683438 45687140
Maternal drugs affecting foetus 45.22 9.92 109 315375 5409 46365169
Cytomegalovirus infection 45.01 9.92 34 315450 18110 46352468
Neck deformity 44.95 9.92 59 315425 1795 46368783
Vomiting 44.73 9.92 2554 312930 450240 45920338
Hepatic function abnormal 44.11 9.92 105 315379 34316 46336262
Pre-eclampsia 43.60 9.92 136 315348 7858 46362720
Injection site rash 43.60 9.92 217 315267 15596 46354982
Rheumatoid nodule 43.37 9.92 147 315337 8873 46361705
Hepatic enzyme increased 43.23 9.92 785 314699 81002 46289576
Diabetic ketoacidosis 42.82 9.92 36 315448 18174 46352404
Product use in unapproved indication 42.56 9.92 397 315087 89876 46280702
Loss of personal independence in daily activities 42.43 9.92 581 314903 56602 46313976
Juvenile idiopathic arthritis 42.10 9.92 89 315395 4043 46366535
Gestational diabetes 41.41 9.92 125 315359 7094 46363484
Pain in extremity 41.03 9.92 2139 313345 256541 46114037
Hepatocellular injury 40.32 9.92 87 315397 29435 46341143
Drug resistance 40.03 9.92 35 315449 17333 46353245
Herpes zoster 40.02 9.92 663 314821 67209 46303369
Blood pressure systolic abnormal 39.98 9.92 104 315380 5413 46365165
Intentional product misuse 39.93 9.92 173 315311 46955 46323623
Emotional distress 39.89 9.92 93 315391 30614 46339964
Influenza 39.80 9.92 835 314649 88435 46282143
Hyperglycaemia 39.59 9.92 114 315370 34957 46335621
Foetal exposure during pregnancy 39.29 9.92 348 315136 30399 46340179
Ejection fraction decreased 39.14 9.92 38 315446 17899 46352679
Osteonecrosis of jaw 38.71 9.92 112 315372 34290 46336288
Foot deformity 38.58 9.92 206 315278 15219 46355359
Peripheral swelling 38.51 9.92 1367 314117 156704 46213874
Cardiac failure congestive 38.47 9.92 415 315069 91335 46279243
Palmar-plantar erythrodysaesthesia syndrome 38.41 9.92 49 315435 20402 46350176
Somnolence 38.16 9.92 787 314697 155734 46214844
Anaphylactic reaction 38.02 9.92 207 315277 52905 46317673
Mydriasis 37.93 9.92 12 315472 10541 46360037
Delirium 37.79 9.92 127 315357 37101 46333477
Urticaria 37.61 9.92 565 314919 117327 46253251
Pulmonary embolism 37.59 9.92 512 314972 108073 46262505
Femur fracture 37.56 9.92 399 315085 36598 46333980
Encephalopathy 37.32 9.92 110 315374 33479 46337099
Dizziness 37.32 9.92 1900 313584 338514 46032064
Insomnia 37.10 9.92 840 314644 164084 46206494
Neoplasm progression 36.97 9.92 78 315406 26605 46343973
Blood creatine phosphokinase increased 36.79 9.92 83 315401 27641 46342937
Nodule 36.74 9.92 205 315279 15400 46355178
Respiratory failure 36.57 9.92 437 315047 94379 46276199
Asthenia 36.48 9.92 1724 313760 309351 46061227
Infective pulmonary exacerbation of cystic fibrosis 35.91 9.92 14 315470 10793 46359785
Tuberculosis 35.84 9.92 151 315333 10114 46360464
Therapeutic response decreased 35.61 9.92 447 315037 42698 46327880
Hyperkalaemia 35.55 9.92 199 315285 50510 46320068
Shock 35.45 9.92 58 315426 21787 46348791
Limb deformity 35.25 9.92 76 315408 3500 46367078
Altered state of consciousness 35.15 9.92 65 315419 23283 46347295
Hypoxia 34.96 9.92 206 315278 51632 46318946
Metabolic acidosis 34.94 9.92 139 315345 38641 46331937
Syncope 34.92 9.92 498 314986 104305 46266273
Renal impairment 34.66 9.92 328 315156 74044 46296534
Malignant melanoma 34.54 9.92 149 315335 10085 46360493
Hypothermia 34.03 9.92 20 315464 12163 46358415
Hyperhidrosis 33.91 9.92 413 315071 88895 46281683
Bone erosion 33.82 9.92 140 315344 9303 46361275
Musculoskeletal pain 33.58 9.92 663 314821 69465 46301113
Restlessness 33.40 9.92 77 315407 25447 46345131
Ventricular septal defect 33.39 9.92 80 315404 3954 46366624
General physical health deterioration 33.20 9.92 566 314918 115203 46255375
Disturbance in attention 33.18 9.92 106 315378 31454 46339124
Multiple sclerosis relapse 33.09 9.92 159 315325 41966 46328612
Premature delivery 32.57 9.92 258 315226 21811 46348767
Hepatic failure 32.56 9.92 116 315368 33300 46337278
Multiple organ dysfunction syndrome 32.53 9.92 210 315274 51500 46319078
Cerebral haemorrhage 32.18 9.92 92 315392 28279 46342299
Injection site warmth 31.82 9.92 180 315304 13592 46356986
Arthritis infective 31.68 9.92 91 315393 5022 46365556
Bronchitis 31.35 9.92 938 314546 105041 46265537
Condition aggravated 31.26 9.92 1987 313497 243065 46127513
Respiratory depression 31.07 9.92 20 315464 11580 46358998
Small for dates baby 31.05 9.92 73 315411 3564 46367014
No adverse event 30.65 9.92 123 315361 34108 46336470
Grip strength decreased 30.36 9.92 127 315357 8479 46362099
Myocardial infarction 30.22 9.92 470 315014 97058 46273520
Smear cervix abnormal 30.18 9.92 58 315426 2458 46368120
Oral herpes 29.90 9.92 229 315255 19161 46351417
Developmental hip dysplasia 29.83 9.92 40 315444 1243 46369335
Disorientation 29.79 9.92 138 315346 36780 46333798
Hypokalaemia 29.77 9.92 417 315067 87607 46282971
Extrapyramidal disorder 29.41 9.92 20 315464 11248 46359330
Weight increased 29.36 9.92 1376 314108 163097 46207481
Blood pressure diastolic decreased 29.13 9.92 180 315304 14031 46356547
Neck mass 29.11 9.92 67 315417 3226 46367352
Myalgia 29.08 9.92 622 314862 122466 46248112
Blood pressure systolic increased 29.01 9.92 310 315174 28477 46342101
Heart rate decreased 28.95 9.92 335 315149 31388 46339190
Thrombocytopenia 28.94 9.92 643 314841 125938 46244640
Brain oedema 28.93 9.92 25 315459 12453 46358125
Hallucination 28.87 9.92 208 315276 49743 46320835
Loss of consciousness 28.25 9.92 538 314946 107700 46262878
Seizure 28.15 9.92 625 314859 122429 46248149
Multiple fractures 27.90 9.92 92 315392 5475 46365103
Coma 27.75 9.92 256 315228 58093 46312485
Premature rupture of membranes 27.68 9.92 79 315405 4344 46366234
Disseminated intravascular coagulation 27.65 9.92 54 315430 18951 46351627
Anaphylactic shock 27.47 9.92 60 315424 20214 46350364
Torsade de pointes 27.40 9.92 25 315459 12129 46358449
Fibromyalgia 27.25 9.92 371 315113 36092 46334486
Inflammation 27.11 9.92 472 315012 48309 46322269
Metastases to bone 26.89 9.92 48 315436 17428 46353150
Joint destruction 26.71 9.92 62 315422 3002 46367576
Enthesopathy 26.70 9.92 81 315403 4609 46365969
Accidental overdose 26.69 9.92 60 315424 20006 46350572
Metastases to liver 26.51 9.92 58 315426 19527 46351051
Abnormal behaviour 26.38 9.92 65 315419 20993 46349585
Contusion 26.33 9.92 776 314708 86711 46283867
Skin ulcer 26.24 9.92 335 315149 32123 46338455
Postoperative wound infection 26.21 9.92 123 315361 8630 46361948
Neutrophil count decreased 25.99 9.92 179 315305 43247 46327331
Dyspnoea exertional 25.97 9.92 216 315268 50073 46320505
Cyst 25.91 9.92 155 315329 11945 46358633
Aspartate aminotransferase increased 25.84 9.92 375 315109 78325 46292253
Surgery 25.83 9.92 303 315181 28482 46342096
Blood pressure diastolic increased 25.83 9.92 94 315390 5880 46364698
Posterior reversible encephalopathy syndrome 25.71 9.92 39 315445 15102 46355476
Synovial cyst 25.60 9.92 108 315376 7238 46363340
Drug intolerance 25.55 9.92 1227 314257 145822 46224756
Joint stiffness 25.51 9.92 288 315196 26820 46343758
Product administration error 25.25 9.92 60 315424 19621 46350957
Inappropriate antidiuretic hormone secretion 25.24 9.92 35 315449 14067 46356511
Haemoglobin decreased 25.23 9.92 1089 314395 127860 46242718
Gastroenteritis viral 25.21 9.92 209 315275 17910 46352668
Ventricular tachycardia 24.87 9.92 48 315436 16919 46353659
Swollen joint count increased 24.81 9.92 52 315432 2348 46368230
Tenosynovitis stenosans 24.70 9.92 46 315438 1903 46368675
Skin papilloma 24.61 9.92 73 315411 4103 46366475
Decreased appetite 24.56 9.92 1065 314419 192771 46177807
Fracture 24.55 9.92 193 315291 16278 46354300
Latent tuberculosis 24.52 9.92 46 315438 1914 46368664
Off label use 24.32 9.92 2223 313261 377618 45992960
Skin cancer 24.27 9.92 121 315363 8702 46361876
Rheumatic fever 24.20 9.92 57 315427 2786 46367792
Cellulitis 23.82 9.92 633 314851 69655 46300923
Blood pressure increased 23.74 9.92 1065 314419 125601 46244977
Tenderness 23.63 9.92 195 315289 16686 46353892
Respiratory distress 23.61 9.92 123 315361 31793 46338785
Complication of device insertion 23.18 9.92 3 315481 4941 46365637
Psychotic disorder 23.07 9.92 77 315407 22544 46348034
Acute hepatic failure 23.04 9.92 40 315444 14681 46355897
Leukopenia 23.02 9.92 324 315160 68019 46302559
Blood bilirubin increased 22.97 9.92 136 315348 34048 46336530
Pyrexia 22.95 9.92 2037 313447 346765 46023813
Placental disorder 22.75 9.92 37 315447 1372 46369206
Polyhydramnios 22.66 9.92 45 315439 1954 46368624
Angioedema 22.65 9.92 164 315320 39178 46331400
Deep vein thrombosis 22.54 9.92 391 315093 79382 46291196
Transplant rejection 22.53 9.92 19 315465 9577 46361001
Mental status changes 22.30 9.92 158 315326 37930 46332648
Wheezing 22.16 9.92 242 315242 53144 46317434
Atrioventricular block complete 22.05 9.92 12 315472 7615 46362963
Pulmonary tuberculosis 21.78 9.92 76 315408 4655 46365923
Foot fracture 21.69 9.92 215 315269 19367 46351211
Chest discomfort 21.65 9.92 455 315029 89814 46280764
Blood glucose increased 21.64 9.92 349 315135 71664 46298914
Dry eye 21.64 9.92 306 315178 30016 46340562
Unresponsive to stimuli 21.62 9.92 128 315356 32046 46338532
Drug level increased 21.51 9.92 59 315425 18382 46352196
Immunosuppression 21.44 9.92 104 315380 7396 46363182
Squamous cell carcinoma 21.23 9.92 107 315377 7729 46362849
Orthostatic hypotension 21.20 9.92 90 315394 24568 46346010
Akathisia 21.08 9.92 13 315471 7701 46362877
Serum ferritin increased 21.07 9.92 81 315403 5202 46365376
Blood pressure decreased 21.06 9.92 266 315218 56893 46313685
Agranulocytosis 20.96 9.92 78 315406 22107 46348471
Suicidal ideation 20.92 9.92 262 315222 56120 46314458
International normalised ratio increased 20.89 9.92 209 315275 46674 46323904
Neurotoxicity 20.81 9.92 38 315446 13679 46356899
Arrhythmia 20.66 9.92 144 315340 34697 46335881
Synovial fluid analysis 20.64 9.92 35 315449 1344 46369234
Alanine aminotransferase increased 20.58 9.92 448 315036 88003 46282575
Acute generalised exanthematous pustulosis 20.43 9.92 20 315464 9385 46361193
Cystitis 20.43 9.92 400 315084 41841 46328737
Device dislocation 20.37 9.92 77 315407 21725 46348853
Laryngitis 20.37 9.92 120 315364 9196 46361382
Plasma cell myeloma 20.36 9.92 197 315287 44281 46326297
Immunodeficiency 20.32 9.92 155 315329 12951 46357627
Respiratory disorder 20.32 9.92 105 315379 27195 46343383
Rash 20.26 9.92 2727 312757 353785 46016793
Acute chest syndrome 20.19 9.92 22 315462 548 46370030
Fluid retention 20.16 9.92 234 315250 50812 46319766
Stress cardiomyopathy 20.07 9.92 14 315470 7770 46362808
Pancytopenia 20.05 9.92 733 314751 84325 46286253
Oedema 19.84 9.92 326 315158 66745 46303833
Speech disorder 19.75 9.92 153 315331 36014 46334564
Polyarthritis 19.64 9.92 92 315392 6450 46364128
Blood alkaline phosphatase increased 19.61 9.92 172 315312 39437 46331141
Clear cell renal cell carcinoma 19.58 9.92 29 315455 990 46369588
Erythema multiforme 19.55 9.92 22 315462 9682 46360896
Tooth infection 19.44 9.92 146 315338 12140 46358438
Injection site urticaria 19.39 9.92 143 315341 11824 46358754
Foetal death 19.36 9.92 113 315371 8630 46361948
Bronchospasm 19.27 9.92 49 315435 15658 46354920
Joint range of motion decreased 19.23 9.92 171 315313 14953 46355625
Bradyphrenia 19.22 9.92 9 315475 6221 46364357
Body height below normal 19.19 9.92 40 315444 1799 46368779
Ventricular fibrillation 19.15 9.92 30 315454 11466 46359112
Disability 19.13 9.92 126 315358 10041 46360537
Toxic skin eruption 19.08 9.92 34 315450 12353 46358225
Depression 19.05 9.92 947 314537 169157 46201421
Injection site haemorrhage 19.03 9.92 219 315265 20490 46350088
Thrombotic microangiopathy 18.83 9.92 17 315467 8289 46362289
Loose body in joint 18.80 9.92 29 315455 1027 46369551
Anaemia 18.57 9.92 1482 314002 254297 46116281
Vertigo 18.52 9.92 244 315240 51804 46318774
Dehydration 18.49 9.92 885 314599 158655 46211923
Gamma-glutamyltransferase increased 18.42 9.92 132 315352 31608 46338970
Injection site haematoma 18.38 9.92 86 315398 6026 46364552
Atrial septal defect 18.25 9.92 88 315396 6244 46364334
Congenital arterial malformation 18.20 9.92 17 315467 350 46370228
Coagulopathy 18.17 9.92 64 315420 18435 46352143
Graft versus host disease 18.14 9.92 11 315473 6577 46364001
Gestational hypertension 18.12 9.92 43 315441 2112 46368466
Wheelchair user 18.12 9.92 64 315420 3944 46366634
Injury 18.10 9.92 200 315284 43827 46326751
Mouth ulceration 18.05 9.92 268 315216 26564 46344014
Breast feeding 18.01 9.92 26 315458 867 46369711
Pharyngitis streptococcal 17.83 9.92 108 315376 8360 46362218
Pulmonary fibrosis 17.81 9.92 211 315273 19881 46350697
Schizophrenia 17.73 9.92 19 315465 8549 46362029
Exomphalos 17.71 9.92 20 315464 519 46370059
Synovial disorder 17.70 9.92 25 315459 817 46369761
Diarrhoea 17.67 9.92 3424 312060 556178 45814400
Acute graft versus host disease 17.62 9.92 3 315481 4027 46366551
Blood iron increased 17.61 9.92 32 315452 1299 46369279
Joint injury 17.59 9.92 203 315281 19006 46351572
Asphyxia 17.53 9.92 7 315477 5319 46365259
Melaena 17.36 9.92 113 315371 27659 46342919
Knee operation 17.34 9.92 71 315413 4695 46365883
Acute myeloid leukaemia 17.29 9.92 52 315432 15726 46354852
Antinuclear antibody positive 17.18 9.92 86 315398 6194 46364384
Diabetes mellitus inadequate control 17.18 9.92 40 315444 13174 46357404
Bone disorder 17.15 9.92 209 315275 19824 46350754
Miosis 17.13 9.92 12 315472 6645 46363933
Lupus-like syndrome 17.13 9.92 101 315383 7743 46362835
Eye infection 17.12 9.92 113 315371 9010 46361568
Face oedema 17.03 9.92 69 315415 19084 46351494
Cholecystitis chronic 16.92 9.92 28 315456 10471 46360107
Poor venous access 16.88 9.92 105 315379 8203 46362375
Hypersensitivity 16.85 9.92 1206 314278 149115 46221463
Pain in jaw 16.71 9.92 172 315312 38200 46332378
Neuroleptic malignant syndrome 16.71 9.92 31 315453 11091 46359487
Aggression 16.63 9.92 88 315396 22656 46347922
Nightmare 16.58 9.92 57 315427 16541 46354037
Carpal tunnel syndrome 16.55 9.92 172 315312 15687 46354891
Mania 16.50 9.92 30 315454 10816 46359762
Bone marrow failure 16.44 9.92 125 315359 29544 46341034
Foetal distress syndrome 16.42 9.92 30 315454 1223 46369355
Diverticulitis 16.36 9.92 314 315170 32725 46337853
Substance abuse 16.35 9.92 4 315480 4163 46366415
Scleritis 16.31 9.92 50 315434 2862 46367716
Rotator cuff repair 16.29 9.92 33 315451 1454 46369124
Catheter site pain 16.27 9.92 3 315481 3803 46366775
Joint noise 16.27 9.92 53 315431 3134 46367444
Anhedonia 16.25 9.92 28 315456 10307 46360271
Viral infection 16.24 9.92 291 315193 29944 46340634
Device use error 16.21 9.92 7 315477 5074 46365504
Polyneuropathy 16.16 9.92 34 315450 11610 46358968
Cholestasis of pregnancy 16.13 9.92 28 315456 1096 46369482
Spinal stenosis 16.04 9.92 142 315342 12401 46358177
Dysarthria 15.95 9.92 169 315315 37329 46333249
Crying 15.91 9.92 81 315403 21060 46349518
Hyperuricaemia 15.86 9.92 6 315478 4711 46365867
Pulmonary hypertension 15.81 9.92 161 315323 35832 46334746
Pleural effusion 15.78 9.92 433 315051 82519 46288059
Hypomania 15.75 9.92 5 315479 4383 46366195
Maternal exposure during breast feeding 15.72 9.92 48 315436 2741 46367837
Vision blurred 15.71 9.92 414 315070 79294 46291284
Injection site irritation 15.70 9.92 64 315420 4223 46366355
Ischaemic stroke 15.66 9.92 59 315425 16663 46353915
Ear infection 15.53 9.92 230 315254 22783 46347795
Second primary malignancy 15.50 9.92 13 315471 6571 46364007
Rhinorrhoea 15.50 9.92 427 315057 47238 46323340
Palpitations 15.46 9.92 508 314976 94751 46275827
Eosinophilia 15.40 9.92 72 315412 19145 46351433
Cognitive disorder 15.38 9.92 167 315317 36716 46333862
Cervical incompetence 15.38 9.92 20 315464 603 46369975
Sedation complication 15.32 9.92 3 315481 3642 46366936
Human antichimeric antibody positive 15.32 9.92 31 315453 1365 46369213
Arthritis bacterial 15.31 9.92 78 315406 5658 46364920
Post procedural infection 15.30 9.92 95 315389 7418 46363160
Tachypnoea 15.22 9.92 48 315436 14303 46356275
Device difficult to use 15.21 9.92 19 315465 7985 46362593
Cushingoid 15.21 9.92 83 315401 6183 46364395
Fear 15.19 9.92 57 315427 16115 46354463
Talipes 15.15 9.92 31 315453 1376 46369202
Pancreatitis acute 15.14 9.92 102 315382 24770 46345808
Chronic kidney disease 15.13 9.92 190 315294 40681 46329897
Tumour lysis syndrome 15.03 9.92 16 315468 7220 46363358
Blood creatinine increased 15.01 9.92 397 315087 76006 46294572
Myopathy 14.96 9.92 23 315461 8858 46361720
Maternal exposure before pregnancy 14.94 9.92 65 315419 4416 46366162
Renal injury 14.86 9.92 26 315458 9515 46361063
Antibody test positive 14.86 9.92 40 315444 2125 46368453
Shock haemorrhagic 14.85 9.92 22 315462 8602 46361976
Hiatus hernia 14.83 9.92 189 315295 18113 46352465
Hospitalisation 14.75 9.92 321 315163 63064 46307514
Ascites 14.72 9.92 167 315317 36417 46334161
Starvation ketoacidosis 14.68 9.92 8 315476 66 46370512
Cartilage injury 14.68 9.92 33 315451 1564 46369014
Bone density abnormal 14.60 9.92 50 315434 3034 46367544
Stillbirth 14.44 9.92 84 315400 6407 46364171
Hallucination, auditory 14.43 9.92 32 315452 10724 46359854
Carcinoma in situ of skin 14.27 9.92 12 315472 214 46370364
Haemorrhage 14.22 9.92 273 315211 54596 46315982
Transplant dysfunction 14.08 9.92 7 315477 4675 46365903
Joint dislocation 13.98 9.92 126 315358 11060 46359518
Joint lock 13.95 9.92 38 315446 2033 46368545
Weight decreased 13.91 9.92 1628 313856 209221 46161357
Rash maculo-papular 13.82 9.92 121 315363 27753 46342825
Cytokine release syndrome 13.79 9.92 13 315471 6210 46364368
Crystal nephropathy 13.78 9.92 22 315462 803 46369775
Metastases to central nervous system 13.77 9.92 35 315449 11186 46359392
Dyskinesia 13.71 9.92 127 315357 28798 46341780
Dactylitis 13.70 9.92 27 315457 1166 46369412
Fracture delayed union 13.68 9.92 39 315445 2143 46368435
Alcoholic liver disease 13.68 9.92 9 315475 108 46370470
Chest pain 13.66 9.92 1016 314468 175308 46195270
Feeling abnormal 13.65 9.92 698 314786 124362 46246216
Cerebrovascular accident 13.65 9.92 551 314933 100488 46270090
Pancreatitis 13.59 9.92 210 315274 43417 46327161
Complication associated with device 13.50 9.92 56 315428 15385 46355193
Haemorrhage in pregnancy 13.17 9.92 32 315452 1596 46368982
Atrial fibrillation 13.13 9.92 569 314915 103021 46267557
Tooth disorder 13.13 9.92 226 315258 23077 46347501
Sinus congestion 13.13 9.92 141 315343 12968 46357610
Ingrown hair 13.10 9.92 16 315468 452 46370126
Sickle cell anaemia 13.07 9.92 18 315466 574 46370004
Induced labour 13.05 9.92 23 315461 911 46369667
Muscle spasticity 13.05 9.92 37 315447 11403 46359175
Dysgeusia 12.92 9.92 194 315290 40297 46330281
Tenosynovitis 12.87 9.92 91 315393 7424 46363154
Naevus flammeus 12.82 9.92 9 315475 121 46370457
Injection site induration 12.78 9.92 96 315388 7983 46362595
Haemophagocytic lymphohistiocytosis 12.76 9.92 23 315461 8319 46362259
Injection site extravasation 12.71 9.92 84 315400 6701 46363877
Lip swelling 12.69 9.92 110 315374 25285 46345293
Cerebral infarction 12.69 9.92 99 315385 23267 46347311
Product adhesion issue 12.66 9.92 9 315475 4946 46365632
Status epilepticus 12.66 9.92 50 315434 13929 46356649
Oliguria 12.65 9.92 25 315459 8734 46361844
Haematotoxicity 12.62 9.92 17 315467 6916 46363662
Hallucination, visual 12.60 9.92 70 315414 17803 46352775
Joint warmth 12.57 9.92 27 315457 1240 46369338
Skin laceration 12.52 9.92 185 315299 18317 46352261
Stevens-Johnson syndrome 12.51 9.92 99 315385 23198 46347380
Bursitis 12.50 9.92 196 315288 19646 46350932
Lymphoma 12.50 9.92 111 315373 9702 46360876
Paralysis 12.50 9.92 25 315459 8696 46361882
Pemphigoid 12.48 9.92 12 315472 5679 46364899
Hypertransaminasaemia 12.48 9.92 4 315480 3484 46367094
Lymphadenectomy 12.44 9.92 22 315462 874 46369704
Aspergillus infection 12.43 9.92 17 315467 6873 46363705
Body temperature decreased 12.41 9.92 142 315342 13267 46357311
Panic attack 12.33 9.92 83 315401 20159 46350419
Inflammatory marker increased 12.28 9.92 71 315413 5404 46365174
Wrong technique in product usage process 12.27 9.92 277 315207 54145 46316433
Withdrawal syndrome 12.26 9.92 72 315412 18062 46352516
Upper respiratory tract infection 12.25 9.92 536 314948 63020 46307558
Infection 12.21 9.92 1055 314429 132537 46238041
Pulmonary oedema 12.13 9.92 258 315226 50847 46319731
Proteinuria 12.13 9.92 64 315420 16489 46354089
Anterior chamber cleavage syndrome 12.09 9.92 10 315474 174 46370404
Parkinsonism 12.08 9.92 22 315462 7926 46362652
Genital haemorrhage 12.05 9.92 16 315468 6550 46364028
Bundle branch block right 11.99 9.92 9 315475 4810 46365768
Bone contusion 11.97 9.92 21 315463 829 46369749
Platelet count decreased 11.95 9.92 553 314931 99471 46271107
Oedema peripheral 11.94 9.92 923 314561 158783 46211795
Limb injury 11.93 9.92 189 315295 18985 46351593
Metastases to lung 11.90 9.92 35 315449 10661 46359917
Pancreatic steatosis 11.85 9.92 23 315461 982 46369596
Premature baby 11.83 9.92 180 315304 17932 46352646
Foetal anticonvulsant syndrome 11.82 9.92 15 315469 441 46370137
Autism spectrum disorder 11.82 9.92 17 315467 565 46370013
Abortion missed 11.77 9.92 30 315454 1542 46369036
Bradypnoea 11.77 9.92 3 315481 3036 46367542
Ketoacidosis 11.76 9.92 6 315478 3949 46366629
Coronary artery disease 11.72 9.92 159 315325 33593 46336985
Hypoglycaemia neonatal 11.72 9.92 22 315462 916 46369662
Breast cancer metastatic 11.71 9.92 50 315434 13628 46356950
Forceps delivery 11.67 9.92 10 315474 183 46370395
Placental insufficiency 11.67 9.92 27 315457 1304 46369274
Failed induction of labour 11.67 9.92 13 315471 332 46370246
Intervertebral disc degeneration 11.67 9.92 139 315345 13113 46357465
Incorrect product administration duration 11.65 9.92 30 315454 9547 46361031
Cytomegalovirus viraemia 11.62 9.92 8 315476 4470 46366108
Anuria 11.59 9.92 39 315445 11392 46359186
Creatinine renal clearance decreased 11.58 9.92 18 315466 6902 46363676
Foetal alcohol syndrome 11.56 9.92 5 315479 23 46370555
Mood altered 11.48 9.92 47 315437 12960 46357618
Human anti-human antibody test 11.46 9.92 13 315471 339 46370239
Red blood cell sedimentation rate 11.42 9.92 32 315452 1741 46368837
Haematocrit decreased 11.38 9.92 314 315170 34743 46335835
Bowen's disease 11.37 9.92 11 315473 237 46370341
Cytopenia 11.36 9.92 22 315462 7746 46362832
Tendon disorder 11.35 9.92 65 315419 4930 46365648
Uterine contractions during pregnancy 11.35 9.92 16 315468 522 46370056
Febrile bone marrow aplasia 11.34 9.92 18 315466 6844 46363734
Vacuum extractor delivery 11.30 9.92 9 315475 148 46370430
Haemorrhage intracranial 11.21 9.92 46 315438 12678 46357900
Chondropathy 11.19 9.92 34 315450 1936 46368642
Sinus tachycardia 11.17 9.92 93 315391 21556 46349022
Lymphatic fistula 11.14 9.92 21 315463 877 46369701
Renal mass 11.14 9.92 32 315452 1766 46368812
Wound infection pseudomonas 11.14 9.92 28 315456 1427 46369151
Atrioventricular block 11.13 9.92 18 315466 6793 46363785
Morning sickness 11.06 9.92 18 315466 668 46369910
Ulcer 11.03 9.92 172 315312 17220 46353358
Colitis microscopic 11.02 9.92 17 315467 6539 46364039
Femoral hernia incarcerated 10.96 9.92 21 315463 888 46369690
Nail injury 10.95 9.92 14 315470 415 46370163
Tubulointerstitial nephritis 10.93 9.92 57 315427 14731 46355847
Obstructive airways disorder 10.90 9.92 50 315434 13362 46357216
Pathogen resistance 10.89 9.92 15 315469 6045 46364533
Cardiac failure acute 10.87 9.92 24 315460 8054 46362524
Ileus paralytic 10.85 9.92 8 315476 4315 46366263
Myofascial pain syndrome 10.77 9.92 33 315451 1888 46368690
Jaundice 10.71 9.92 134 315350 28711 46341867
Accidental exposure to product 10.68 9.92 91 315393 20990 46349588
Endodontic procedure 10.66 9.92 39 315445 2446 46368132
Kidney infection 10.64 9.92 166 315318 16623 46353955
Stress at work 10.62 9.92 22 315462 985 46369593
Hepatocellular carcinoma 10.62 9.92 3 315481 2836 46367742
Tinea pedis 10.61 9.92 27 315457 1386 46369192
C-reactive protein increased 10.61 9.92 491 314993 58099 46312479
Cardiogenic shock 10.58 9.92 66 315418 16318 46354260
Bite 10.54 9.92 13 315471 371 46370207
Lung neoplasm malignant 10.53 9.92 155 315329 15334 46355244
Hernia 10.52 9.92 106 315378 9589 46360989
Catheter site erythema 10.49 9.92 7 315477 3976 46366602
Tardive dyskinesia 10.49 9.92 22 315462 7521 46363057
Animal bite 10.48 9.92 37 315447 2280 46368298
Pregnancy with contraceptive device 10.47 9.92 9 315475 4494 46366084
Skin infection 10.46 9.92 120 315364 11219 46359359
Multiple sclerosis 10.44 9.92 112 315372 24679 46345899
Myocarditis 10.41 9.92 23 315461 7716 46362862
Nodal osteoarthritis 10.39 9.92 19 315465 775 46369803
Inflammatory pain 10.38 9.92 17 315467 634 46369944
Dysphagia 10.36 9.92 422 315062 76890 46293688
Bronchopulmonary aspergillosis 10.31 9.92 22 315462 7474 46363104
Complication of pregnancy 10.31 9.92 15 315469 504 46370074
Uterine perforation 10.27 9.92 21 315463 7246 46363332
Vascular rupture 10.26 9.92 25 315459 1249 46369329
Tonsillitis 10.25 9.92 63 315421 4901 46365677
Mass 10.16 9.92 122 315362 11531 46359047
Drug ineffective for unapproved indication 10.14 9.92 67 315417 16346 46354232
Drug-induced liver injury 10.13 9.92 116 315368 25252 46345326
Lung neoplasm 10.12 9.92 70 315414 5670 46364908
Osteopenia 10.11 9.92 166 315318 16795 46353783
Large for dates baby 10.11 9.92 14 315470 449 46370129
Decreased insulin requirement 10.08 9.92 8 315476 131 46370447
Mean cell volume increased 10.06 9.92 42 315442 2802 46367776
Congenital hydronephrosis 10.04 9.92 13 315471 390 46370188
Aspiration 10.03 9.92 32 315452 9499 46361079
Body mass index decreased 10.02 9.92 12 315472 332 46370246
Abortion threatened 10.02 9.92 16 315468 584 46369994
Dysmorphism 9.99 9.92 32 315452 1875 46368703

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Rheumatoid arthritis 385.54 10.07 708 145375 40489 29765906
Drug abuse 300.96 10.07 27 146056 82045 29724350
Completed suicide 250.98 10.07 86 145997 99406 29706989
Toxicity to various agents 204.22 10.07 344 145739 176839 29629556
Arthralgia 183.78 10.07 1212 144871 134579 29671816
Foetal exposure during pregnancy 174.36 10.07 483 145600 36388 29770007
Psoriatic arthropathy 103.45 10.07 234 145849 15527 29790868
Sickle cell anaemia with crisis 91.24 10.07 83 146000 2319 29804076
Joint swelling 87.98 10.07 457 145626 46489 29759906
Drug interaction 86.98 10.07 593 145490 198975 29607420
Premature baby 72.38 10.07 212 145871 16479 29789916
Exposure during pregnancy 70.49 10.07 146 145937 9115 29797280
Enthesopathy 64.15 10.07 75 146008 2831 29803564
Neonatal respiratory distress syndrome 62.39 10.07 87 145996 3925 29802470
Death 61.75 10.07 1302 144781 355981 29450414
Intentional overdose 61.33 10.07 67 146016 41414 29764981
Tenosynovitis 60.39 10.07 80 146003 3435 29802960
Atrial septal defect 58.65 10.07 112 145971 6589 29799806
Nasopharyngitis 58.17 10.07 488 145595 58361 29748034
Overdose 56.98 10.07 215 145868 84122 29722273
Blood pressure fluctuation 56.54 10.07 201 145882 17302 29789093
Acute kidney injury 52.02 10.07 982 145101 272860 29533535
Lower respiratory tract infection 50.68 10.07 261 145822 26453 29779942
Musculoskeletal stiffness 50.65 10.07 324 145759 35557 29770838
Maternal drugs affecting foetus 48.46 10.07 80 146003 4193 29802202
Hepatic function abnormal 46.75 10.07 83 146000 41862 29764533
Hypospadias 46.07 10.07 61 146022 2618 29803777
Drug resistance 44.82 10.07 21 146062 20112 29786283
Maternal exposure during pregnancy 43.27 10.07 72 146011 3799 29802596
Haemoglobin decreased 42.44 10.07 787 145296 113311 29693084
Synovitis 41.21 10.07 123 145960 9660 29796735
Maternal exposure during breast feeding 40.92 10.07 45 146038 1587 29804808
Small for dates baby 40.41 10.07 63 146020 3145 29803250
Tongue disorder 40.02 10.07 74 146009 4248 29802147
Product use in unapproved indication 39.96 10.07 204 145879 73489 29732906
Drug reaction with eosinophilia and systemic symptoms 39.95 10.07 48 146035 28440 29777955
Dysmorphism 39.52 10.07 49 146034 1968 29804427
Ventricular septal defect 38.59 10.07 65 146018 3464 29802931
Hypoglycaemia neonatal 38.57 10.07 43 146040 1540 29804855
Intentional product misuse 38.27 10.07 69 146014 34598 29771797
Low birth weight baby 37.43 10.07 88 145995 5988 29800407
Pain 37.33 10.07 1104 144979 171537 29634858
Psoriasis 37.08 10.07 343 145740 42163 29764232
Suicide attempt 37.07 10.07 77 146006 36620 29769775
Rhabdomyolysis 35.04 10.07 175 145908 63405 29742990
Febrile neutropenia 34.93 10.07 342 145741 106351 29700044
C-reactive protein abnormal 34.45 10.07 81 146002 5512 29800883
Respiratory arrest 33.41 10.07 57 146026 29201 29777194
Drug dependence 33.04 10.07 33 146050 21262 29785133
Drug intolerance 32.50 10.07 351 145732 44940 29761455
Arthritis 31.80 10.07 216 145867 24185 29782210
Drug withdrawal syndrome 31.54 10.07 30 146053 19779 29786616
Cardiac failure 31.41 10.07 258 145825 83160 29723235
Syndactyly 31.01 10.07 27 146056 711 29805684
Infusion related reaction 30.81 10.07 318 145765 40246 29766149
Poisoning 30.15 10.07 9 146074 11373 29795022
Cryptorchism 30.10 10.07 39 146044 1638 29804757
Pulmonary fibrosis 29.96 10.07 155 145928 15735 29790660
Peripheral swelling 29.59 10.07 440 145643 60634 29745761
Basal cell carcinoma 29.10 10.07 155 145928 15913 29790482
Large for dates baby 29.08 10.07 28 146055 842 29805553
Blood pressure systolic increased 28.91 10.07 148 145935 14962 29791433
Exposure via breast milk 28.91 10.07 37 146046 1535 29804860
Foetal anticonvulsant syndrome 27.95 10.07 26 146057 748 29805647
Arthropathy 27.92 10.07 185 145898 20542 29785853
Pancytopenia 27.66 10.07 575 145508 84477 29721918
Alanine aminotransferase abnormal 25.72 10.07 46 146037 2573 29803822
Blood pressure systolic abnormal 25.43 10.07 34 146049 1473 29804922
Cytomegalovirus infection 25.35 10.07 48 146035 23626 29782769
Skin cancer 25.35 10.07 91 145992 7870 29798525
Osteoarthritis 24.85 10.07 164 145919 18185 29788210
Renal failure 24.54 10.07 462 145621 128504 29677891
Loss of personal independence in daily activities 24.22 10.07 184 145899 21351 29785044
Renal impairment 23.85 10.07 279 145804 83905 29722490
Congenital hand malformation 23.62 10.07 19 146064 447 29805948
Cardiac arrest 23.57 10.07 315 145768 92535 29713860
Pathogen resistance 23.49 10.07 6 146077 8404 29797991
Medical device implantation 23.34 10.07 20 146063 515 29805880
Juvenile idiopathic arthritis 23.16 10.07 27 146056 1016 29805379
Off label use 23.00 10.07 988 145095 248302 29558093
Hypoglycaemia 22.87 10.07 150 145933 50831 29755564
Pain in extremity 22.74 10.07 701 145382 109520 29696875
Suicidal ideation 22.51 10.07 95 145988 36019 29770376
Rheumatoid nodule 22.43 10.07 34 146049 1656 29804739
Body temperature decreased 22.41 10.07 100 145983 9555 29796840
Musculoskeletal pain 22.29 10.07 240 145843 30700 29775695
Knee arthroplasty 22.04 10.07 69 146014 5561 29800834
Serum ferritin increased 21.63 10.07 67 146016 5370 29801025
Arthritis bacterial 21.60 10.07 59 146024 4405 29801990
Multiple organ dysfunction syndrome 21.40 10.07 202 145881 63285 29743110
Coma 21.34 10.07 113 145970 40336 29766059
Selective eating disorder 21.11 10.07 33 146050 1651 29804744
Hyperglycaemia 21.08 10.07 94 145989 35106 29771289
Palmar-plantar erythrodysaesthesia syndrome 20.91 10.07 25 146058 14845 29791550
Asthma 20.83 10.07 98 145985 36076 29770319
Tendonitis 20.78 10.07 86 145997 7950 29798445
Injection site pain 20.41 10.07 232 145851 30078 29776317
Caesarean section 20.30 10.07 37 146046 2100 29804295
Agitation neonatal 20.24 10.07 25 146058 1000 29805395
Shock 19.84 10.07 52 146031 22807 29783588
Substance abuse 19.70 10.07 5 146078 7035 29799360
Pyrexia 19.02 10.07 1210 144873 293279 29513116
Vitamin D deficiency 19.00 10.07 62 146021 5108 29801287
Infective pulmonary exacerbation of cystic fibrosis 18.99 10.07 9 146074 8563 29797832
Back disorder 18.64 10.07 68 146015 5926 29800469
Blood pressure increased 18.62 10.07 471 145612 71457 29734938
Weight decreased 18.57 10.07 907 145176 150014 29656381
Hand deformity 18.52 10.07 33 146050 1840 29804555
Talipes 18.51 10.07 31 146052 1644 29804751
Disease progression 18.49 10.07 276 145807 79598 29726797
Product quality issue 18.45 10.07 40 146043 18734 29787661
Neck mass 18.42 10.07 28 146055 1367 29805028
Osteonecrosis of jaw 18.02 10.07 40 146043 18578 29787817
Infection 17.85 10.07 503 145580 77571 29728824
Lacrimal disorder 17.82 10.07 14 146069 318 29806077
Cleft lip 17.78 10.07 14 146069 319 29806076
Haemangioma congenital 17.72 10.07 17 146066 509 29805886
Speech disorder developmental 17.49 10.07 25 146058 1154 29805241
Cellulitis 17.46 10.07 323 145760 46461 29759934
Hyperbilirubinaemia neonatal 17.25 10.07 19 146064 671 29805724
Blood pressure diastolic increased 17.05 10.07 40 146043 2718 29803677
Foetal growth restriction 16.96 10.07 47 146036 3538 29802857
Post procedural infection 16.96 10.07 55 146028 4517 29801878
Kidney infection 16.91 10.07 55 146028 4523 29801872
Poisoning deliberate 16.90 10.07 4 146079 5900 29800495
Pneumonia 16.71 10.07 1868 144215 332438 29473957
Congenital bladder anomaly 16.63 10.07 13 146070 293 29806102
Poor venous access 16.47 10.07 37 146046 2443 29803952
Bradycardia 16.37 10.07 223 145860 65303 29741092
Umbilical hernia 16.35 10.07 47 146036 3614 29802781
Joint effusion 16.33 10.07 47 146036 3616 29802779
Influenza 16.33 10.07 300 145783 43098 29763297
Mucormycosis 16.25 10.07 3 146080 5265 29801130
Venoocclusive liver disease 16.16 10.07 6 146077 6607 29799788
Bradycardia neonatal 15.97 10.07 21 146062 895 29805500
Jaundice neonatal 15.89 10.07 23 146060 1074 29805321
Intentional self-injury 15.78 10.07 26 146057 13506 29792889
Sarcopenia 15.68 10.07 12 146071 262 29806133
Weight decrease neonatal 15.53 10.07 13 146070 324 29806071
Patent ductus arteriosus 15.45 10.07 42 146041 3127 29803268
Somnolence 15.34 10.07 357 145726 96406 29709989
Immunodeficiency 15.34 10.07 51 146032 4243 29802152
Prostate cancer 15.08 10.07 181 145902 23776 29782619
Ankyloglossia congenital 15.07 10.07 12 146071 278 29806117
Arthrodesis 14.87 10.07 14 146069 409 29805986
Injection site bruising 14.83 10.07 73 146010 7265 29799130
Agranulocytosis 14.76 10.07 56 146027 21886 29784509
Joint range of motion decreased 14.68 10.07 62 146021 5783 29800612
Urticaria 14.68 10.07 183 145900 54423 29751972
Back pain 14.65 10.07 626 145457 101970 29704425
Decreased gait velocity 14.57 10.07 8 146075 96 29806299
Hypermobility syndrome 14.57 10.07 11 146072 235 29806160
Neutropenia 14.56 10.07 497 145586 128043 29678352
Foetal disorder 14.55 10.07 17 146066 641 29805754
Alcoholic liver disease 14.53 10.07 17 146066 642 29805753
Wound 14.53 10.07 107 145976 12295 29794100
Peripheral artery thrombosis 14.49 10.07 33 146050 2199 29804196
Acute hepatic failure 14.48 10.07 22 146061 11805 29794590
Depressed level of consciousness 14.47 10.07 118 145965 38104 29768291
Malignant melanoma 14.46 10.07 73 146010 7338 29799057
Hypertriglyceridaemia 14.44 10.07 11 146072 8087 29798308
Lactic acidosis 14.42 10.07 91 145992 31122 29775273
Multiple congenital abnormalities 14.42 10.07 15 146068 496 29805899
Heart rate decreased 14.27 10.07 161 145922 20833 29785562
Urinary tract infection 14.27 10.07 465 145618 73194 29733201
Failure to anastomose 14.26 10.07 11 146072 243 29806152
Renal aplasia 14.14 10.07 17 146066 661 29805734
Red blood cell count decreased 14.08 10.07 193 145890 26128 29780267
Grip strength decreased 14.01 10.07 32 146051 2136 29804259
Tonsil cancer 14.00 10.07 18 146065 750 29805645
Rash maculo-papular 13.97 10.07 70 146013 25348 29781047
Septic arthritis staphylococcal 13.96 10.07 14 146069 443 29805952
Emphysema 13.94 10.07 86 145997 9316 29797079
Anal fistula 13.93 10.07 47 146036 3939 29802456
Incorrect route of product administration 13.90 10.07 21 146062 11294 29795101
Fall 13.72 10.07 1047 145036 180825 29625570
Haematocrit decreased 13.64 10.07 218 145865 30481 29775914
Angioedema 13.55 10.07 105 145978 34279 29772116
Aggression 13.49 10.07 115 145968 36792 29769603
Otitis media 13.47 10.07 35 146048 2536 29803859
Arthritis infective 13.36 10.07 36 146047 2666 29803729
Foot deformity 13.34 10.07 42 146041 3395 29803000
Cerebral haemorrhage neonatal 13.32 10.07 11 146072 269 29806126
Cirrhosis alcoholic 13.20 10.07 18 146065 795 29805600
Contraindicated product administered 13.04 10.07 135 145948 17096 29789299
Hydrocele 13.02 10.07 30 146053 2014 29804381
Joint stiffness 12.88 10.07 84 145999 9277 29797118
Knee deformity 12.85 10.07 12 146071 347 29806048
Injection site swelling 12.83 10.07 80 146003 8700 29797695
Vascular insufficiency 12.79 10.07 12 146071 349 29806046
Aptyalism 12.73 10.07 10 146073 227 29806168
Maternal exposure timing unspecified 12.71 10.07 12 146071 352 29806043
Congenital anomaly 12.70 10.07 23 146060 1299 29805096
Hernia pain 12.70 10.07 10 146073 228 29806167
Blood pressure diastolic decreased 12.60 10.07 62 146021 6169 29800226
Psychotic disorder 12.55 10.07 58 146025 21457 29784938
Aspergillus infection 12.51 10.07 19 146064 10195 29796200
Pleural fibrosis 12.47 10.07 24 146059 1420 29804975
Mobility decreased 12.46 10.07 187 145896 25812 29780583
Mean cell volume increased 12.39 10.07 30 146053 2080 29804315
Proteinuria 12.35 10.07 39 146044 16106 29790289
Cystitis haemorrhagic 12.29 10.07 4 146079 4783 29801612
Blood insulin increased 12.27 10.07 12 146071 368 29806027
Decreased vibratory sense 12.27 10.07 12 146071 368 29806027
Disseminated intravascular coagulation 12.22 10.07 61 146022 22110 29784285
Neurotoxicity 12.21 10.07 29 146054 13153 29793242
Anal atresia 12.16 10.07 11 146072 305 29806090
Blood creatinine increased 12.11 10.07 346 145737 91029 29715366
Transaminases increased 12.11 10.07 66 146017 23391 29783004
Akathisia 11.90 10.07 7 146076 5897 29800498
Pulmonary tuberculosis 11.80 10.07 51 146032 4806 29801589
Progressive multifocal leukoencephalopathy 11.79 10.07 16 146067 8997 29797398
Palindromic rheumatism 11.78 10.07 9 146074 196 29806199
Skin lesion 11.76 10.07 140 145943 18354 29788041
Injection site erythema 11.74 10.07 111 145972 13723 29792672
Plagiocephaly 11.64 10.07 11 146072 323 29806072
Neonatal seizure 11.63 10.07 13 146070 467 29805928
Drug withdrawal syndrome neonatal 11.60 10.07 38 146045 3137 29803258
Crohn's disease 11.59 10.07 47 146036 4305 29802090
Diverticular perforation 11.59 10.07 38 146045 3139 29803256
Excessive cerumen production 11.53 10.07 10 146073 262 29806133
Renal injury 11.51 10.07 25 146058 11704 29794691
Gangrene neonatal 11.43 10.07 9 146074 205 29806190
Autism spectrum disorder 11.42 10.07 22 146061 1303 29805092
Malignant neoplasm progression 11.37 10.07 267 145816 72020 29734375
Pouchitis 11.36 10.07 15 146068 642 29805753
Sinusitis 11.34 10.07 227 145856 33118 29773277
Intellectual disability 11.32 10.07 17 146066 821 29805574
Moaning 11.19 10.07 16 146067 739 29805656
Lung neoplasm malignant 11.19 10.07 118 145965 15014 29791381
Mastication disorder 11.14 10.07 20 146063 1122 29805273
Hypocalcaemia 11.11 10.07 60 146023 21316 29785079
Coma scale abnormal 11.10 10.07 39 146044 3337 29803058
Blood iron increased 11.08 10.07 17 146066 837 29805558
Foetal heart rate deceleration abnormality 11.08 10.07 12 146071 416 29805979
Congenital diaphragmatic hernia 11.00 10.07 9 146074 217 29806178
C-reactive protein decreased 10.99 10.07 24 146059 1554 29804841
Hepatitis 10.94 10.07 64 146019 22292 29784103
Pulmonary artery stenosis congenital 10.93 10.07 13 146070 500 29805895
Brain oedema 10.91 10.07 28 146055 12370 29794025
Hyperbilirubinaemia 10.91 10.07 44 146039 16898 29789497
Injection site rash 10.88 10.07 40 146043 3499 29802896
Altered state of consciousness 10.87 10.07 55 146028 19864 29786531
Oedema 10.85 10.07 146 145937 42847 29763548
Tuberculosis 10.82 10.07 72 146011 8005 29798390
Dermatitis psoriasiform 10.78 10.07 20 146063 1151 29805244
Lipase increased 10.76 10.07 16 146067 8660 29797735
Pulmonary arterial hypertension 10.73 10.07 18 146065 9283 29797112
Nerve compression 10.66 10.07 34 146049 2768 29803627
Blood pressure diastolic abnormal 10.64 10.07 21 146062 1266 29805129
Steatorrhoea 10.52 10.07 15 146068 691 29805704
Foetal hypokinesia 10.52 10.07 11 146072 366 29806029
Anti-erythropoietin antibody positive 10.51 10.07 17 146066 876 29805519
Foetal distress syndrome 10.50 10.07 18 146065 973 29805422
Respiratory rate increased 10.49 10.07 77 146006 8838 29797557
Finger deformity 10.49 10.07 18 146065 974 29805421
Mouth ulceration 10.48 10.07 88 145995 10521 29795874
Erectile dysfunction 10.44 10.07 49 146034 18053 29788342
Acute graft versus host disease 10.41 10.07 8 146075 5856 29800539
Anaemia vitamin B12 deficiency 10.40 10.07 10 146073 300 29806095
Cholestasis 10.40 10.07 75 146008 24875 29781520
Oropharyngeal pain 10.37 10.07 196 145887 28300 29778095
Folate deficiency 10.27 10.07 18 146065 991 29805404
Spinal disorder 10.19 10.07 38 146045 3347 29803048
Hepatic siderosis 10.17 10.07 8 146075 182 29806213
Pyelocaliectasis 10.16 10.07 18 146065 999 29805396
Joint instability 10.09 10.07 11 146072 384 29806011
Erythrosis 10.07 10.07 5 146078 48 29806347

Pharmacologic Action:

SourceCodeDescription
ATC A11DA01 ALIMENTARY TRACT AND METABOLISM
VITAMINS
VITAMIN B1, PLAIN AND IN COMBINATION WITH VITAMIN B6 AND B12
Vitamin B1, plain
MeSH PA D018977 Micronutrients
MeSH PA D014803 Vitamin B Complex
MeSH PA D014815 Vitamins
CHEBI has role CHEBI:27314 water-soluble vitamins
CHEBI has role CHEBI:75771 mus musculus metabolite
CHEBI has role CHEBI:75772 baker's yeast metabolite
CHEBI has role CHEBI:76971 e.coli metabolites
CHEBI has role CHEBI:77746 h. sapiens metabolites

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Korsakoff's psychosis indication 69482004 DOID:10915
Pernicious anemia indication 84027009 DOID:13381
Vitamin deficiency indication 85670002
Mineral deficiency indication 111379007
Cobalamin deficiency indication 190634004
Thiamin deficiency indication 399357009 DOID:0070313
Vitamin Deficiency Prevention indication
Mineral Deficiency Prevention indication
Prevention of Vitamin B12 Deficiency indication
Methylmalonic acidemia off-label use 42393006
Necrotizing enterocolitis in fetus OR newborn contraindication 2707005
Alcoholism contraindication 7200002
Peptic ulcer contraindication 13200003 DOID:750
Myocardial infarction contraindication 22298006 DOID:5844
Hypertensive disorder contraindication 38341003 DOID:10763
Gastrointestinal ulcer contraindication 40845000
Hypokalemia contraindication 43339004
Conduction disorder of the heart contraindication 44808001
Chronic heart failure contraindication 48447003
Gastrointestinal perforation contraindication 51875005
Gastrectomy contraindication 53442002
Leber's optic atrophy contraindication 58610003 DOID:705
Hepatic failure contraindication 59927004
Blood coagulation disorder contraindication 64779008 DOID:1247
Agoraphobia contraindication 70691001 DOID:593
Gastrointestinal hemorrhage contraindication 74474003
Atrophic gastritis contraindication 84568007 DOID:8929
Kidney disease contraindication 90708001 DOID:557
Hemophilia contraindication 90935002
Seizure disorder contraindication 128613002
Obsessive-compulsive disorder contraindication 191736004 DOID:10933
Insomnia contraindication 193462001
Impaired renal function disorder contraindication 197663003
Coronary artery bypass graft contraindication 232717009
Disease of liver contraindication 235856003 DOID:409
Pregnancy, function contraindication 289908002
Panic disorder contraindication 371631005 DOID:594
Cardiovascular event risk contraindication 395112001
Myocardial ischemia contraindication 414795007 DOID:3393
Myocardial infarction in recovery phase contraindication 418044006
Smokes tobacco daily contraindication 449868002
Acute Thromboembolic Stroke contraindication

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 4.94 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Heat shock protein HSP 90-alpha Cytosolic other IC50 4.90 CHEMBL
Transketolase-like protein 1 Enzyme WOMBAT-PK
Thiamine-triphosphatase Enzyme WOMBAT-PK
Thiamin pyrophosphokinase 1 Kinase WOMBAT-PK
Transketolase Enzyme WOMBAT-PK
Thiamine transporter 1 Transporter WOMBAT-PK

External reference:

IDSource
4017777 VUID
N0000146138 NUI
D08580 KEGG_DRUG
67-03-8 SECONDARY_CAS_RN
4017446 VANDF
4017474 VANDF
4017634 VANDF
4017777 VANDF
4021900 VANDF
C0039840 UMLSCUI
CHEBI:33283 CHEBI
VIB PDB_CHEM_ID
CHEMBL1547 ChEMBL_ID
CHEMBL1588 ChEMBL_ID
CHEMBL1200941 ChEMBL_ID
CHEMBL2104496 ChEMBL_ID
D013831 MESH_DESCRIPTOR_UI
C000712172 MESH_SUPPLEMENTAL_RECORD_UI
432 INN_ID
DB00152 DRUGBANK_ID
X66NSO3N35 UNII
1130 PUBCHEM_CID
4629 IUPHAR_LIGAND_ID
10454 RXNORM
1096 MMSL
15466 MMSL
41397 MMSL
5566 MMSL
5681 MMSL
7276 MMSL
d03130 MMSL
001061 NDDF
001062 NDDF
003860 NDDF
126228004 SNOMEDCT_US
126229007 SNOMEDCT_US
259659006 SNOMEDCT_US
30306003 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
NataFort HUMAN PRESCRIPTION DRUG LABEL 10 0178-0716 TABLET 2 mg ORAL Unapproved drug other 12 sections
CitraNatal 90 DHA HUMAN PRESCRIPTION DRUG LABEL 16 0178-0821 TABLET 3 mg ORAL unapproved drug other 11 sections
CitraNatal 90 DHA HUMAN PRESCRIPTION DRUG LABEL 16 0178-0821 TABLET 4.54 mg ORAL unapproved drug other 11 sections
CitraNatal 90 DHA HUMAN OTC DRUG LABEL 14 0178-0829 TABLET 3 mg ORAL Unapproved drug other 11 sections
CitraNatal Rx HUMAN PRESCRIPTION DRUG LABEL 13 0178-0858 TABLET 3 mg ORAL Unapproved drug other 12 sections
CitraNatal Rx HUMAN PRESCRIPTION DRUG LABEL 14 0178-0859 TABLET 3 mg ORAL Unapproved drug other 9 sections
CitraNatal DHA HUMAN OTC DRUG LABEL 14 0178-0898 TABLET 3 mg ORAL Unapproved drug other 11 sections
Thiamine Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0641-6228 INJECTION, SOLUTION 100 mg INTRAMUSCULAR ANDA 15 sections
VitafolOne HUMAN PRESCRIPTION DRUG LABEL 16 0642-0070 CAPSULE, GELATIN COATED 1.60 mg ORAL unapproved drug other 7 sections
Vitafol Caplet HUMAN PRESCRIPTION DRUG LABEL 12 0642-0072 CAPSULE 1.10 mg ORAL UNULLPPROVED DRUG OTHER 13 sections
Select OB HUMAN PRESCRIPTION DRUG LABEL 15 0642-0077 TABLET, CHEWABLE 1.60 mg ORAL UNULLPPROVED DRUG OTHER 14 sections
Vitafol OB Caplet HUMAN PRESCRIPTION DRUG LABEL 15 0642-0079 TABLET 1.60 mg ORAL Unapproved drug other 14 sections
Vitafol Plus HUMAN PRESCRIPTION DRUG LABEL 17 0642-0092 CAPSULE, LIQUID FILLED 1.60 mg ORAL UNULLPPROVED DRUG OTHER 13 sections
Vitafol Ultra HUMAN PRESCRIPTION DRUG LABEL 17 0642-0093 CAPSULE, LIQUID FILLED 1.60 mg ORAL UNULLPPROVED DRUG OTHER 13 sections
Select OB HUMAN PRESCRIPTION DRUG LABEL 15 0642-0120 TABLET, CHEWABLE 1.60 mg ORAL UNULLPPROVED DRUG OTHER 13 sections
Strovite Forte Caplet HUMAN PRESCRIPTION DRUG LABEL 19 0642-0204 TABLET, COATED 20 mg ORAL UNULLPPROVED DRUG OTHER 15 sections
Strovite One Caplets HUMAN PRESCRIPTION DRUG LABEL 20 0642-0207 TABLET 20 mg ORAL UNULLPPROVED DRUG OTHER 14 sections
Reaphirm Plant Source DHA HUMAN PRESCRIPTION DRUG LABEL 16 0642-3010 CAPSULE, GELATIN COATED 1.60 mg ORAL unapproved drug other 7 sections
Vitafol Fe Plus HUMAN PRESCRIPTION DRUG LABEL 17 0642-7473 CAPSULE, LIQUID FILLED 1.60 mg ORAL UNULLPPROVED DRUG OTHER 14 sections
Marnatal F HUMAN PRESCRIPTION DRUG LABEL 13 0682-1570 CAPSULE 3 mg ORAL UNULLPPROVED DRUG OTHER 4 sections
BACMIN HUMAN PRESCRIPTION DRUG LABEL 19 0682-3001 TABLET, COATED 20 mg ORAL UNULLPPROVED DRUG OTHER 10 sections
O-Cal Prenatal Vitamin HUMAN PRESCRIPTION DRUG LABEL 16 0813-0202 TABLET 1.50 mg ORAL UNULLPPROVED DRUG OTHER 6 sections
Dialyvite Supreme D HUMAN PRESCRIPTION DRUG LABEL 13 10542-009 TABLET, COATED 1.50 mg ORAL Unapproved drug other 7 sections
Dialyvite HUMAN PRESCRIPTION DRUG LABEL 9 10542-010 TABLET, COATED 1.50 mg ORAL Unapproved drug other 7 sections
Dialyvite 5000 HUMAN PRESCRIPTION DRUG LABEL 12 10542-011 TABLET, COATED 1.50 mg ORAL Unapproved drug other 7 sections
Dialyvite with Zinc HUMAN PRESCRIPTION DRUG LABEL 10 10542-012 TABLET, COATED 1.50 mg ORAL Unapproved drug other 7 sections
Dialyvite 3000 HUMAN PRESCRIPTION DRUG LABEL 12 10542-014 TABLET, COATED 1.50 mg ORAL Unapproved drug other 7 sections
PRENULLTAL PLUS HUMAN PRESCRIPTION DRUG LABEL 15 10544-549 TABLET, FILM COATED 1.84 mg ORAL unapproved drug other 8 sections
PRENULLTAL PLUS IRON HUMAN PRESCRIPTION DRUG LABEL 15 10544-609 TABLET, FILM COATED 1.84 mg ORAL UNULLPPROVED DRUG OTHER 7 sections
Se-Natal 19 HUMAN PRESCRIPTION DRUG LABEL 15 13925-116 TABLET 3 mg ORAL unapproved drug other 15 sections