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tosufloxacin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| antibacterials, nalidixic acid derivatives | 2710 | 100490-36-6 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
quinolone anti-infective agent; structure given in first source
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 0.45 | g | O |
ADMET properties:
None
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2B,GRK2,PDK1,PDK2,PDK4 | 5 | |||
| kinase-selectivity-class | CAMK2D,DYRK1B,EIF2AK3,GRK2,MAPK7,PRKDC,STK33 | 7 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | J01MA22 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE QUINOLONE ANTIBACTERIALS Fluoroquinolones |
| ATC | S01AE09 | SENSORY ORGANS OPHTHALMOLOGICALS ANTIINFECTIVES Fluoroquinolones |
| CHEBI has role | CHEBI:33281 | antimicrobial agent |
| CHEBI has role | CHEBI:33282 | antibacterial agent |
| CHEBI has role | CHEBI:35441 | antiinfective agent |
| CHEBI has role | CHEBI:50908 | hepatotoxic agent |
| CHEBI has role | CHEBI:53559 | topoisomerase IV inhibitor |
| CHEBI has role | CHEBI:59517 | DNA synthesis inhibitor |
| CHEBI has role | CHEBI:66981 | ophthalmology drug |
Related Drugs by ATC class:
J01MA Fluoroquinolones 22 drugs
S01AE Fluoroquinolones 8 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 5.92 | acidic |
| pKa2 | 8.7 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| D02317 | KEGG_DRUG |
| 115964-29-9 | SECONDARY_CAS_RN |
| C0076843 | UMLSCUI |
| CHEBI:77573 | CHEBI |
| CHEMBL273348 | ChEMBL_ID |
| CHEMBL104270 | ChEMBL_ID |
| DB16850 | DRUGBANK_ID |
| C055185 | MESH_SUPPLEMENTAL_RECORD_UI |
| 5517 | PUBCHEM_CID |
| 12878 | IUPHAR_LIGAND_ID |
| 6242 | INN_ID |
| GHJ553KQPS | UNII |
| 008167 | NDDF |
| 008169 | NDDF |
| 104051-69-6 | SECONDARY_CAS_RN |
Pharmaceutical products:
None