tosufloxacin Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antibacterials, nalidixic acid derivatives 2710 100490-36-6

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • tosufloxacin tosylate
  • tosufloxacin tosilate hydrate
  • tosufloxacin
  • tosulfloxacin
  • tosufloxacin tosilate
  • tosufloxacin hydrochloride
  • tosufloxacin HCl
quinolone anti-infective agent; structure given in first source
  • Molecular weight: 404.35
  • Formula: C19H15F3N4O3
  • CLOGP: -1.09
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 2
  • TPSA: 99.76
  • ALOGS: -3.72
  • ROTB: 3

Drug dosage:

DoseUnitRoute
0.45 g O

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug reaction with eosinophilia and systemic symptoms 48.12 0 7 5 5511 2352562

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event

Pharmacologic Action:

SourceCodeDescription
ATC J01MA22 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
QUINOLONE ANTIBACTERIALS
Fluoroquinolones
CHEBI has role CHEBI:35441 antiinfective agent

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 5.92 acidic
pKa2 8.7 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D02317 KEGG_DRUG
008167 NDDF
CHEMBL273348 ChEMBL_ID
CHEMBL104270 ChEMBL_ID
GHJ553KQPS UNII
6242 INN_ID
104051-69-6 SECONDARY_CAS_RN
CHEBI:77573 CHEBI
5517 PUBCHEM_CID
C055185 MESH_SUPPLEMENTAL_RECORD_UI

Pharmaceutical products:

None