moxifloxacin ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antibacterials, nalidixic acid derivatives 1854 151096-09-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • avelox
  • moxifloxacin
  • moxifloxacin hydrochloride
  • avolex
  • moxeza
  • moxifloxacine
  • moxifloxacin HCl
A fluoroquinolone that acts as an inhibitor of DNA TOPOISOMERASE II and is used as a broad-spectrum antibacterial agent.
  • Molecular weight: 401.44
  • Formula: C21H24FN3O4
  • CLOGP: -0.12
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 2
  • TPSA: 82.11
  • ALOGS: -3.38
  • ROTB: 4

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.40 g O
0.40 g P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 27.50 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 22 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 14.23 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 86 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 1.40 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 2.40 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.60 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 8.20 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Dec. 10, 1999 FDA BAYER HLTHCARE

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug hypersensitivity 315.38 13.37 508 25821 250502 50328293
Contrast media allergy 306.96 13.37 89 26240 1938 50576857
Toxic anterior segment syndrome 269.68 13.37 76 26253 1489 50577306
Iris transillumination defect 264.65 13.37 45 26284 44 50578751
Corneal oedema 171.20 13.37 52 26277 1335 50577460
Endophthalmitis 169.63 13.37 62 26267 2854 50575941
Hypopyon 150.15 13.37 40 26289 629 50578166
Electrocardiogram QT prolonged 148.50 13.37 158 26171 51728 50527067
Torsade de pointes 133.98 13.37 81 26248 11754 50567041
Obliterative bronchiolitis 128.95 13.37 45 26284 1808 50576987
Drug resistance 127.78 13.37 94 26235 18895 50559900
Corneal infiltrates 106.38 13.37 22 26307 102 50578693
Visual acuity reduced 105.62 13.37 86 26243 20053 50558742
Corneal epithelium defect 89.48 13.37 23 26306 312 50578483
Upper respiratory tract infection 88.66 13.37 138 26191 65760 50513035
Eye pain 87.37 13.37 90 26239 28359 50550436
Corneal opacity 87.09 13.37 26 26303 628 50578167
Musculoskeletal injury 83.43 13.37 18 26311 106 50578689
Asthma-chronic obstructive pulmonary disease overlap syndrome 81.52 13.37 23 26306 452 50578343
Pigment dispersion syndrome 78.74 13.37 12 26317 0 50578795
Loss of employment 71.52 13.37 28 26301 1558 50577237
Drug intolerance 70.45 13.37 262 26067 218842 50359953
Drug reaction with eosinophilia and systemic symptoms 66.57 13.37 78 26251 28346 50550449
Nicotine dependence 65.89 13.37 21 26308 634 50578161
Psoriasis 65.75 13.37 124 26205 68876 50509919
Sputum purulent 65.52 13.37 23 26306 940 50577855
Ulcerative keratitis 64.26 13.37 29 26300 2304 50576491
Total lung capacity increased 63.74 13.37 21 26308 706 50578089
Vitritis 63.61 13.37 22 26307 860 50577935
Neuropathy peripheral 62.13 13.37 148 26181 96609 50482186
Ocular hyperaemia 61.94 13.37 64 26265 20228 50558567
Mental disorder 61.16 13.37 66 26263 21925 50556870
Asthma 59.91 13.37 139 26190 89198 50489597
Anaphylactic reaction 58.94 13.37 103 26226 53952 50524843
Paradoxical drug reaction 57.51 13.37 31 26298 3616 50575179
Acinetobacter infection 56.72 13.37 23 26306 1404 50577391
Oesophageal spasm 55.29 13.37 26 26303 2270 50576525
Secondary immunodeficiency 53.66 13.37 21 26308 1167 50577628
Nasal polyps 52.66 13.37 26 26303 2528 50576267
Hepatic steatosis 52.31 13.37 64 26265 24320 50554475
Systemic lupus erythematosus 52.24 13.37 6 26323 140616 50438179
Tuberculoma of central nervous system 52.09 13.37 15 26314 318 50578477
Pemphigus 50.48 13.37 3 26326 120163 50458632
Anterior chamber cell 50.36 13.37 16 26313 478 50578317
Arthropathy 49.13 13.37 11 26318 157895 50420900
Vision blurred 49.07 13.37 119 26210 78528 50500267
Punctate keratitis 48.47 13.37 16 26313 541 50578254
Conjunctival hyperaemia 48.37 13.37 23 26306 2059 50576736
Glossodynia 48.20 13.37 3 26326 115566 50463229
Lymphoedema 47.91 13.37 39 26290 9083 50569712
Herpes zoster 47.29 13.37 110 26219 70676 50508119
Corneal perforation 46.62 13.37 15 26314 467 50578328
Oesophageal pain 44.69 13.37 24 26305 2778 50576017
Synovitis 44.27 13.37 6 26323 123859 50454936
Corneal disorder 44.11 13.37 20 26309 1606 50577189
Wheezing 42.08 13.37 97 26232 61950 50516845
Photophobia 41.95 13.37 45 26284 14842 50563953
Thrombocytopenia 41.22 13.37 153 26176 127520 50451275
Eye pruritus 40.92 13.37 41 26288 12493 50566302
Alopecia 39.00 13.37 42 26287 245005 50333790
Anterior chamber disorder 38.58 13.37 9 26320 79 50578716
Dysbiosis 38.26 13.37 14 26315 646 50578149
Tinnitus 37.92 13.37 59 26270 28073 50550722
Hand deformity 37.91 13.37 4 26325 100195 50478600
Bronchitis chronic 37.46 13.37 24 26305 3853 50574942
Stenotrophomonas infection 37.44 13.37 18 26311 1651 50577144
Toxic epidermal necrolysis 37.01 13.37 50 26279 20942 50557853
Off label use 36.56 13.37 392 25937 474034 50104761
Intraocular pressure increased 36.40 13.37 27 26302 5489 50573306
Iris atrophy 36.40 13.37 8 26321 52 50578743
Retinal haemorrhage 36.15 13.37 25 26304 4556 50574239
Tendonitis 36.08 13.37 44 26285 16661 50562134
Skin injury 35.38 13.37 17 26312 1557 50577238
Dysphoria 35.22 13.37 25 26304 4749 50574046
Factor V deficiency 33.92 13.37 8 26321 74 50578721
Forced expiratory volume decreased 32.39 13.37 23 26306 4371 50574424
Product dose omission issue 32.12 13.37 29 26300 183809 50394986
Cough 32.02 13.37 225 26104 241039 50337756
Ventricular tachycardia 31.49 13.37 40 26289 15781 50563014
Vanishing bile duct syndrome 31.41 13.37 12 26317 625 50578170
Food allergy 31.05 13.37 29 26300 8108 50570687
Skin reaction 30.91 13.37 34 26295 11534 50567261
Foreign body sensation in eyes 30.26 13.37 16 26313 1795 50577000
Tendon pain 30.18 13.37 19 26310 2959 50575836
Cataract 29.95 13.37 72 26257 47228 50531567
Non-infectious endophthalmitis 29.39 13.37 8 26321 137 50578658
Maternal exposure during pregnancy 29.38 13.37 24 26305 159754 50419041
Gastroenteritis staphylococcal 29.18 13.37 7 26322 70 50578725
Eye irritation 28.97 13.37 40 26289 17100 50561695
Full blood count abnormal 28.70 13.37 47 26282 23341 50555454
Drug-induced liver injury 28.63 13.37 52 26277 28043 50550752
Ototoxicity 27.87 13.37 13 26316 1114 50577681
Anterior chamber inflammation 27.86 13.37 9 26320 284 50578511
Embolism venous 27.84 13.37 17 26312 2508 50576287
Eosinophilic pneumonia acute 27.36 13.37 9 26320 301 50578494
Delirium 27.32 13.37 61 26268 38131 50540664
Pathogen resistance 27.13 13.37 23 26306 5666 50573129
Deafness 27.09 13.37 37 26292 15654 50563141
Eye infection staphylococcal 26.79 13.37 6 26323 43 50578752
Allergy to metals 26.43 13.37 10 26319 507 50578288
Iris hypopigmentation 26.25 13.37 4 26325 0 50578795
Corneal flap complication 26.25 13.37 4 26325 0 50578795
Stevens-Johnson syndrome 25.74 13.37 43 26286 21709 50557086
Sarcoidosis 25.40 13.37 21 26308 4996 50573799
Sputum discoloured 25.30 13.37 33 26296 13362 50565433
Corneal erosion 25.24 13.37 8 26321 237 50578558
Morganella infection 25.23 13.37 10 26319 575 50578220
Haemostasis 25.18 13.37 8 26321 239 50578556
Vitreous opacities 24.96 13.37 8 26321 246 50578549
Wound 24.80 13.37 12 26317 105782 50473013
Increased viscosity of bronchial secretion 24.75 13.37 8 26321 253 50578542
Eye inflammation 24.25 13.37 19 26310 4189 50574606
Obstructive airways disorder 24.19 13.37 35 26294 15617 50563178
Rash erythematous 24.19 13.37 55 26274 34797 50543998
Nosocomial infection 24.17 13.37 13 26316 1509 50577286
Fibrin 24.01 13.37 4 26325 3 50578792
Fall 23.62 13.37 92 26237 334840 50243955
Hepatotoxicity 23.56 13.37 47 26282 27179 50551616
Iodine allergy 23.48 13.37 10 26319 691 50578104
Nervous system disorder 23.23 13.37 35 26294 16188 50562607
Retinal ischaemia 23.02 13.37 8 26321 317 50578478
Infective keratitis 22.69 13.37 5 26324 33 50578762
Paraneoplastic syndrome 22.60 13.37 9 26320 524 50578271
Persistent corneal epithelial defect 22.59 13.37 4 26325 6 50578789
Rhinitis allergic 22.49 13.37 23 26306 7177 50571618
Dehydration 22.21 13.37 28 26301 152421 50426374
Condition aggravated 21.98 13.37 80 26249 296978 50281817
Corneal abscess 21.96 13.37 5 26324 39 50578756
Injection site erythema 21.78 13.37 6 26323 74930 50503865
Treatment failure 21.65 13.37 134 26195 137503 50441292
Pericarditis 21.60 13.37 7 26322 78682 50500113
Rash 21.53 13.37 333 25996 437138 50141657
Peripheral nerve injury 21.36 13.37 8 26321 394 50578401
Cryptococcosis 21.21 13.37 10 26319 878 50577917
Toxicity to various agents 20.95 13.37 50 26279 212449 50366346
Trichophytosis 20.58 13.37 5 26324 53 50578742
Mediastinal effusion 20.58 13.37 5 26324 53 50578742
Vitreous floaters 20.39 13.37 19 26310 5295 50573500
Optic neuropathy 20.22 13.37 12 26317 1682 50577113
Gastric disorder 19.81 13.37 46 26283 29502 50549293
Gonioscopy abnormal 19.69 13.37 3 26326 0 50578795
Bronchial ulceration 19.69 13.37 3 26326 0 50578795
Sinus pain 19.41 13.37 13 26316 2248 50576547
Gait disturbance 19.41 13.37 30 26299 149975 50428820
Forced vital capacity abnormal 19.09 13.37 4 26325 20 50578775
Skin odour abnormal 19.08 13.37 11 26318 1461 50577334
Caffeine allergy 18.93 13.37 4 26325 21 50578774
Bronchiectasis 18.90 13.37 25 26304 10258 50568537
Type I hypersensitivity 18.78 13.37 13 26316 2372 50576423
Retinal vasculitis 18.68 13.37 9 26320 829 50577966
Respiratory moniliasis 18.61 13.37 6 26323 188 50578607
Polyneuropathy 18.56 13.37 27 26302 12104 50566691
Back pain 18.50 13.37 56 26273 219974 50358821
Implant site hypersensitivity 18.48 13.37 4 26325 24 50578771
Swelling 18.45 13.37 49 26280 200823 50377972
Pupillary disorder 18.40 13.37 6 26323 195 50578600
Peripheral swelling 18.35 13.37 51 26278 205885 50372910
Hypertransaminasaemia 18.04 13.37 15 26314 3596 50575199
Bronchopulmonary aspergillosis 18.04 13.37 21 26308 7571 50571224
Enterococcal infection 17.95 13.37 20 26309 6878 50571917
Keratitis fungal 17.93 13.37 5 26324 94 50578701
Discomfort 17.86 13.37 18 26311 108362 50470433
Macular cyst 17.82 13.37 4 26325 29 50578766
Death 17.82 13.37 98 26231 325281 50253514
Chest discomfort 17.66 13.37 95 26234 92627 50486168
Fatigue 17.60 13.37 261 26068 707340 49871455
Hyperalbuminaemia 17.37 13.37 4 26325 33 50578762
Visual impairment 17.36 13.37 76 26253 68199 50510596
Vomiting 17.34 13.37 336 25993 460422 50118373
Biopsy colon abnormal 17.23 13.37 5 26324 109 50578686
Corneal neovascularisation 17.23 13.37 5 26324 109 50578686
Eye discharge 17.17 13.37 17 26312 5106 50573689
Rubber sensitivity 16.99 13.37 11 26318 1798 50576997
Rash morbilliform 16.73 13.37 13 26316 2833 50575962
Myelosuppression 16.36 13.37 27 26302 13490 50565305
Musculoskeletal stiffness 16.33 13.37 26 26303 128455 50450340
Pneumonia haemophilus 15.97 13.37 7 26322 519 50578276
Sleep apnoea syndrome 15.83 13.37 37 26292 23831 50554964
Iridocyclitis 15.74 13.37 11 26318 2038 50576757
Tendon rupture 15.72 13.37 19 26310 7125 50571670
Pain in extremity 15.59 13.37 81 26248 272784 50306011
Anterior chamber fibrin 15.58 13.37 4 26325 54 50578741
Wound haemorrhage 15.55 13.37 11 26318 2079 50576716
Lacrimation increased 15.50 13.37 30 26299 16962 50561833
Blister 15.48 13.37 13 26316 85405 50493390
Red blood cell count increased 15.42 13.37 12 26317 2619 50576176
Limb mass 15.25 13.37 12 26317 2663 50576132
Cardiac murmur 15.07 13.37 23 26306 10761 50568034
Detachment of retinal pigment epithelium 15.04 13.37 6 26323 351 50578444
Ventricular hypokinesia 14.83 13.37 14 26315 3966 50574829
Gastrointestinal mucosa hyperaemia 14.77 13.37 5 26324 183 50578612
Metamorphopsia 14.60 13.37 8 26321 963 50577832
Hypertension 14.58 13.37 171 26158 211032 50367763
Productive cough 14.43 13.37 60 26269 52634 50526161
Corneal deposits 14.30 13.37 5 26324 202 50578593
Anaphylactic shock 14.20 13.37 32 26297 20123 50558672
Malignant neoplasm progression 14.12 13.37 9 26320 68115 50510680
Retinal artery occlusion 13.86 13.37 9 26320 1478 50577317
Type IV hypersensitivity reaction 13.86 13.37 11 26318 2471 50576324
Hydrothorax 13.77 13.37 7 26322 724 50578071
Enterocolitis 13.70 13.37 17 26312 6550 50572245
Muscle spasms 13.63 13.37 28 26301 125525 50453270
Eosinophilia 13.57 13.37 30 26299 18622 50560173
Suicide attempt 13.51 13.37 5 26324 51727 50527068
Allergic cough 13.43 13.37 6 26323 465 50578330
Hyperhidrosis 13.39 13.37 86 26243 89340 50489455

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Visual acuity reduced 221.95 14.01 129 18052 14747 29541599
Eye pain 179.46 14.01 103 18078 11492 29544854
Choroiditis 166.80 14.01 49 18132 939 29555407
Intraocular pressure increased 161.25 14.01 72 18109 4717 29551629
Iris transillumination defect 157.06 14.01 25 18156 3 29556343
Endophthalmitis 150.37 14.01 59 18122 2789 29553557
Toxic anterior segment syndrome 147.29 14.01 45 18136 991 29555355
Delirium 144.53 14.01 148 18033 39249 29517097
Electrocardiogram QT prolonged 144.03 14.01 142 18039 35995 29520351
Uveitis 131.63 14.01 67 18114 5880 29550466
Corneal oedema 130.59 14.01 42 18139 1100 29555246
Drug resistance 119.70 14.01 102 18079 21438 29534908
Mental disorder 101.54 14.01 75 18106 12830 29543516
Ulcerative keratitis 95.03 14.01 35 18146 1388 29554958
Hypopyon 94.69 14.01 25 18156 317 29556029
Off label use 92.49 14.01 397 17784 300403 29255943
Dysphoria 85.27 14.01 36 18145 2056 29554290
Anterior chamber cell 74.59 14.01 20 18161 270 29556076
Hepatotoxicity 74.46 14.01 72 18109 17795 29538551
Neuropathy peripheral 74.19 14.01 146 18035 70881 29485465
Paradoxical drug reaction 72.89 14.01 35 18146 2706 29553640
Retinal haemorrhage 72.31 14.01 41 18140 4463 29551883
Corneal infiltrates 72.13 14.01 17 18164 130 29556216
Iridocyclitis 69.62 14.01 28 18153 1412 29554934
Musculoskeletal injury 69.25 14.01 16 18165 111 29556235
Mycotic allergy 66.93 14.01 18 18163 246 29556100
Vitritis 65.21 14.01 22 18159 671 29555675
Spirometry abnormal 64.97 14.01 19 18162 358 29555988
Mite allergy 63.67 14.01 18 18163 299 29556047
Iris hypopigmentation 59.88 14.01 12 18169 37 29556309
Conjunctivitis allergic 58.67 14.01 20 18161 630 29555716
Ototoxicity 57.42 14.01 25 18156 1540 29554806
Dust allergy 55.97 14.01 18 18163 471 29555875
Product use in unapproved indication 54.47 14.01 146 18035 86729 29469617
Painful respiration 53.91 14.01 22 18159 1152 29555194
Conjunctival hyperaemia 49.89 14.01 25 18156 2120 29554226
Walking aid user 49.05 14.01 22 18159 1455 29554891
Pathogen resistance 48.29 14.01 40 18141 8076 29548270
Multiple-drug resistance 48.22 14.01 30 18151 3870 29552476
Drug reaction with eosinophilia and systemic symptoms 46.92 14.01 71 18110 27921 29528425
Visual impairment 46.49 14.01 73 18108 29635 29526711
Chest injury 46.49 14.01 21 18160 1412 29554934
Keratitis fungal 45.58 14.01 10 18171 53 29556293
Corneal perforation 44.82 14.01 12 18169 161 29556185
Skin injury 44.67 14.01 19 18162 1105 29555241
Corneal epithelium defect 40.04 14.01 13 18168 351 29555995
Corneal opacity 39.42 14.01 14 18167 499 29555847
Death 39.38 14.01 96 18085 341988 29214358
Tendonitis 38.78 14.01 35 18146 7926 29548420
Condition aggravated 38.62 14.01 185 17996 146110 29410236
Iris atrophy 37.72 14.01 9 18172 73 29556273
Vision blurred 36.48 14.01 78 18103 40098 29516248
Tendon discomfort 36.27 14.01 11 18170 236 29556110
Diastasis recti abdominis 35.87 14.01 7 18174 18 29556328
Hypoacusis 35.38 14.01 44 18137 14379 29541967
NPM1 gene mutation 33.88 14.01 9 18172 117 29556229
Oral candidiasis 33.45 14.01 37 18144 10685 29545661
Cystoid macular oedema 32.95 14.01 13 18168 623 29555723
Cataract 32.28 14.01 53 18128 22325 29534021
Asthma 32.21 14.01 67 18114 33782 29522564
Vitreous opacities 32.11 14.01 10 18171 235 29556111
Tuberculoma of central nervous system 31.99 14.01 10 18171 238 29556108
Bronchiolitis obliterans syndrome 31.21 14.01 9 18172 161 29556185
Sleep disorder due to a general medical condition 31.03 14.01 21 18160 3125 29553221
Intentional product use issue 30.28 14.01 75 18106 42423 29513923
Urethritis mycoplasmal 30.06 14.01 6 18175 18 29556328
Ocular hyperaemia 29.34 14.01 32 18149 9095 29547251
Overdose 28.49 14.01 7 18174 79812 29476534
Chimerism 28.49 14.01 9 18172 222 29556124
Keratic precipitates 28.46 14.01 8 18173 130 29556216
Keratitis bacterial 28.11 14.01 7 18174 69 29556277
Infective keratitis 28.04 14.01 5 18176 6 29556340
Acute myeloid leukaemia recurrent 28.02 14.01 16 18165 1764 29554582
Tendon pain 27.84 14.01 18 18163 2482 29553864
Retinal detachment 27.67 14.01 23 18158 4663 29551683
Acoustic neuroma 27.64 14.01 8 18173 145 29556201
Eye abscess 27.59 14.01 8 18173 146 29556200
Persistent corneal epithelial defect 27.32 14.01 6 18175 32 29556314
Drug-induced liver injury 26.91 14.01 48 18133 21607 29534739
Toxicity to various agents 26.64 14.01 41 18140 173620 29382726
Corynebacterium infection 26.55 14.01 10 18171 422 29555924
Pigment dispersion syndrome 26.49 14.01 5 18176 10 29556336
Tuberculosis 26.28 14.01 27 18154 7169 29549177
Necrotising scleritis 26.05 14.01 6 18175 41 29556305
Aortic aneurysm 25.78 14.01 25 18156 6195 29550151
Product dose omission issue 25.11 14.01 14 18167 96369 29459977
Flat anterior chamber of eye 24.69 14.01 6 18175 53 29556293
Sitting disability 24.61 14.01 7 18174 119 29556227
Corneal scar 24.08 14.01 7 18174 129 29556217
Tinnitus 23.91 14.01 38 18143 15576 29540770
Anterior chamber inflammation 23.84 14.01 8 18173 240 29556106
Fibrin 23.34 14.01 4 18177 3 29556343
Mycobacterium chelonae infection 23.24 14.01 10 18171 598 29555748
Detachment of retinal pigment epithelium 23.20 14.01 9 18172 412 29555934
Conjunctival oedema 22.88 14.01 9 18172 428 29555918
Deafness unilateral 22.34 14.01 14 18167 1829 29554517
Dehydration 21.83 14.01 23 18158 114725 29441621
Vitreous haemorrhage 21.21 14.01 14 18167 1999 29554347
Photophobia 21.00 14.01 22 18159 5973 29550373
Foreign body sensation in eyes 20.83 14.01 9 18172 544 29555802
Axonal neuropathy 20.45 14.01 10 18171 804 29555542
Deafness neurosensory 20.30 14.01 15 18166 2563 29553783
Immune reconstitution inflammatory syndrome associated tuberculosis 19.90 14.01 8 18173 403 29555943
Blood immunoglobulin G decreased 19.82 14.01 11 18170 1148 29555198
Corneal transplant 19.58 14.01 5 18176 55 29556291
Herpes zoster meningoencephalitis 19.33 14.01 7 18174 264 29556082
Blepharitis allergic 19.19 14.01 3 18178 0 29556346
Chondritis 19.15 14.01 6 18175 144 29556202
Cardiovascular disorder 18.39 14.01 25 18156 8910 29547436
Drug hypersensitivity 18.36 14.01 87 18094 68319 29488027
Metamorphopsia 18.35 14.01 8 18173 494 29555852
Drug ineffective for unapproved indication 18.29 14.01 32 18149 14182 29542164
Incorrect product administration duration 18.19 14.01 17 18164 4024 29552322
Immune reconstitution inflammatory syndrome 17.86 14.01 23 18158 7779 29548567
Haematospermia 17.85 14.01 7 18174 330 29556016
Optic neuritis 17.82 14.01 15 18166 3094 29553252
Mechanical urticaria 17.63 14.01 5 18176 84 29556262
Deafness 17.54 14.01 26 18155 10029 29546317
Torsade de pointes 17.43 14.01 21 18160 6640 29549706
Masticatory pain 17.04 14.01 4 18177 30 29556316
Pulmonary venous thrombosis 16.96 14.01 5 18176 97 29556249
Nervous system disorder 16.92 14.01 29 18152 12645 29543701
Hospitalisation 16.47 14.01 4 18177 45984 29510362
Cerebrovascular accident 16.27 14.01 14 18167 76897 29479449
Emotional distress 16.24 14.01 30 18151 13865 29542481
Hypersomnia 16.23 14.01 26 18155 10728 29545618
Transaminases increased 16.14 14.01 40 18141 22622 29533724
Eye discharge 16.08 14.01 11 18170 1665 29554681
Eye oedema 16.03 14.01 8 18173 672 29555674
Disorganised speech 16.00 14.01 8 18173 675 29555671
Choroidal haematoma 15.89 14.01 3 18178 6 29556340
Ocular icterus 15.78 14.01 13 18168 2602 29553744
Vitreous floaters 15.75 14.01 14 18167 3107 29553239
Pupillary disorder 15.69 14.01 6 18175 264 29556082
Papilloma 15.69 14.01 5 18176 127 29556219
Incision site pain 15.47 14.01 11 18170 1772 29554574
Toxic optic neuropathy 15.38 14.01 8 18173 733 29555613
Product delivery mechanism issue 15.36 14.01 5 18176 136 29556210
Hallucination 15.15 14.01 61 18120 44651 29511695
Mycobacterial infection 15.07 14.01 11 18170 1845 29554501
Neurilemmoma benign 15.03 14.01 3 18178 9 29556337
Phosphorus metabolism disorder 15.03 14.01 3 18178 9 29556337
Feeling cold 14.95 14.01 23 18158 9168 29547178
Scleral thinning 14.79 14.01 3 18178 10 29556336
Pruritus genital 14.67 14.01 7 18174 533 29555813
Corneal disorder 14.65 14.01 8 18173 809 29555537
Pneumothorax 14.65 14.01 31 18150 15811 29540535
Eye infection fungal 14.61 14.01 6 18175 319 29556027
Eyelid oedema 14.46 14.01 16 18165 4620 29551726
Fall 14.44 14.01 58 18123 177120 29379226
Retinal oedema 14.40 14.01 7 18174 556 29555790
Punctate keratitis 14.35 14.01 6 18175 334 29556012
Malabsorption from administration site 14.23 14.01 4 18177 65 29556281

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Toxic anterior segment syndrome 361.44 12.22 110 40540 2329 64455753
Iris transillumination defect 358.60 12.22 64 40586 74 64458008
Endophthalmitis 297.64 12.22 116 40534 5249 64452833
Corneal oedema 285.59 12.22 91 40559 2252 64455830
Visual acuity reduced 275.32 12.22 186 40464 26955 64431127
Electrocardiogram QT prolonged 235.61 12.22 270 40380 79178 64378904
Hypopyon 230.58 12.22 64 40586 965 64457117
Contrast media allergy 227.76 12.22 75 40575 2066 64456016
Drug resistance 203.15 12.22 172 40478 34930 64423152
Eye pain 201.83 12.22 164 40486 31461 64426621
Drug hypersensitivity 193.52 12.22 448 40202 237367 64220715
Intraocular pressure increased 174.22 12.22 91 40559 8211 64449871
Ulcerative keratitis 164.87 12.22 65 40585 3032 64455050
Corneal infiltrates 160.33 12.22 37 40613 248 64457834
Delirium 154.67 12.22 204 40446 68990 64389092
Choroiditis 148.23 12.22 46 40604 1041 64457041
Mental disorder 133.69 12.22 120 40530 26325 64431757
Dysphoria 127.43 12.22 60 40590 4328 64453754
Corneal opacity 122.15 12.22 38 40612 867 64457215
Corneal epithelium defect 119.28 12.22 35 40615 650 64457432
Off label use 117.69 12.22 740 39910 632066 63826016
Anterior chamber cell 117.13 12.22 36 40614 788 64457294
Neuropathy peripheral 113.04 12.22 237 40413 117288 64340794
Vitritis 109.92 12.22 40 40610 1493 64456589
Paradoxical drug reaction 108.56 12.22 60 40590 6060 64452022
Uveitis 105.34 12.22 77 40573 12631 64445451
Drug reaction with eosinophilia and systemic symptoms 103.28 12.22 148 40502 54069 64404013
Obliterative bronchiolitis 98.13 12.22 43 40607 2622 64455460
Corneal perforation 97.72 12.22 30 40620 654 64457428
Conjunctival hyperaemia 94.18 12.22 47 40603 3852 64454230
Hepatotoxicity 91.08 12.22 119 40531 39843 64418239
Pigment dispersion syndrome 90.84 12.22 16 40634 16 64458066
Iris hypopigmentation 81.07 12.22 16 40634 43 64458039
Ocular hyperaemia 79.47 12.22 84 40566 22480 64435602
Asthma 79.00 12.22 181 40469 95044 64363038
Iris atrophy 75.71 12.22 17 40633 99 64457983
Ototoxicity 75.29 12.22 36 40614 2687 64455395
Iridocyclitis 74.42 12.22 37 40613 3008 64455074
Pathogen resistance 73.64 12.22 62 40588 12481 64445601
Vision blurred 73.08 12.22 170 40480 90146 64367936
Torsade de pointes 72.76 12.22 71 40579 17292 64440790
Tuberculoma of central nervous system 69.51 12.22 22 40628 532 64457550
Tendonitis 68.77 12.22 74 40576 20208 64437874
Spirometry abnormal 68.66 12.22 22 40628 554 64457528
Tinnitus 66.20 12.22 94 40556 34039 64424043
Musculoskeletal injury 64.02 12.22 16 40634 156 64457926
Anaphylactic reaction 63.11 12.22 136 40514 68528 64389554
Drug intolerance 62.28 12.22 259 40391 187733 64270349
Loss of employment 61.36 12.22 28 40622 1879 64456203
Oesophageal spasm 59.70 12.22 30 40620 2495 64455587
Retinal haemorrhage 59.45 12.22 44 40606 7354 64450728
Tendon pain 58.35 12.22 37 40613 4811 64453271
Death 58.27 12.22 137 40513 482568 63975514
Multiple-drug resistance 57.54 12.22 41 40609 6461 64451621
Punctate keratitis 56.23 12.22 21 40629 844 64457238
Toxicity to various agents 55.25 12.22 90 40560 363423 64094659
Total lung capacity increased 52.73 12.22 19 40631 689 64457393
Sputum purulent 52.46 12.22 22 40628 1204 64456878
Dust allergy 52.21 12.22 21 40629 1032 64457050
Visual impairment 50.93 12.22 131 40519 73946 64384136
Asthma-chronic obstructive pulmonary disease overlap syndrome 50.87 12.22 21 40629 1104 64456978
Corneal disorder 50.63 12.22 25 40625 2002 64456080
Upper respiratory tract infection 50.34 12.22 129 40521 72656 64385426
Arthropathy 50.26 12.22 8 40642 120959 64337123
Nicotine dependence 50.14 12.22 19 40631 795 64457287
Conjunctivitis allergic 49.21 12.22 20 40630 1010 64457072
Drug-induced liver injury 49.20 12.22 99 40551 47544 64410538
Product use in unapproved indication 48.41 12.22 230 40420 176388 64281694
Keratitis fungal 48.40 12.22 13 40637 172 64457910
Synovitis 47.50 12.22 4 40646 99086 64358996
Bronchitis chronic 47.30 12.22 30 40620 3902 64454180
Infective keratitis 47.05 12.22 10 40640 43 64458039
Persistent corneal epithelial defect 47.05 12.22 10 40640 43 64458039
Vitreous opacities 46.88 12.22 16 40634 493 64457589
Anterior chamber disorder 46.62 12.22 12 40638 133 64457949
Product dose omission issue 46.49 12.22 33 40617 194714 64263368
Acinetobacter infection 46.36 12.22 25 40625 2404 64455678
Mite allergy 44.99 12.22 17 40633 706 64457376
Photophobia 43.34 12.22 54 40596 17239 64440843
Wheezing 42.12 12.22 129 40521 80450 64377632
Oesophageal pain 42.03 12.22 26 40624 3237 64454845
Foreign body sensation in eyes 42.00 12.22 21 40629 1728 64456354
Fibrin 41.24 12.22 8 40642 19 64458063
Chest injury 40.82 12.22 23 40627 2410 64455672
Corneal flap complication 40.26 12.22 7 40643 6 64458076
Mycotic allergy 39.68 12.22 17 40633 981 64457101
Dehydration 38.51 12.22 48 40602 216715 64241367
Tendon discomfort 37.44 12.22 13 40637 422 64457660
NPM1 gene mutation 37.39 12.22 10 40640 130 64457952
Fall 37.36 12.22 136 40514 416690 64041392
Full blood count abnormal 37.09 12.22 67 40583 29690 64428392
Nasal polyps 37.08 12.22 25 40625 3604 64454478
Cataract 36.63 12.22 92 40558 51170 64406912
Keratitis bacterial 36.58 12.22 10 40640 142 64457940
Psoriasis 35.81 12.22 113 40537 71590 64386492
Painful respiration 35.80 12.22 23 40627 3058 64455024
Systemic lupus erythematosus 34.92 12.22 4 40646 77608 64380474
Dysbiosis 34.78 12.22 15 40635 880 64457202
Deafness 34.77 12.22 50 40600 18309 64439773
Diastasis recti abdominis 34.66 12.22 7 40643 22 64458060
Overdose 34.34 12.22 30 40620 159536 64298546
Pupillary disorder 33.12 12.22 12 40638 442 64457640
Hallucination 33.01 12.22 111 40539 72677 64385405
Skin injury 32.96 12.22 19 40631 2080 64456002
Optic neuritis 31.80 12.22 32 40618 8084 64449998
Hyponatraemia 31.79 12.22 28 40622 148311 64309771
Lymphoedema 31.59 12.22 35 40615 9870 64448212
Factor V deficiency 31.14 12.22 8 40642 88 64457994
Bronchiolitis obliterans syndrome 31.13 12.22 10 40640 254 64457828
Secondary immunodeficiency 30.83 12.22 20 40630 2704 64455378
Chimerism 30.69 12.22 10 40640 266 64457816
Retinal detachment 30.43 12.22 31 40619 7945 64450137
Cystoid macular oedema 30.39 12.22 17 40633 1757 64456325
Urethritis mycoplasmal 29.91 12.22 6 40644 18 64458064
Alopecia 29.09 12.22 37 40613 165653 64292429
Suicide attempt 28.81 12.22 5 40645 71002 64387080
Stenotrophomonas infection 28.59 12.22 20 40630 3060 64455022
Hypoacusis 28.20 12.22 55 40595 25812 64432270
Immune reconstitution inflammatory syndrome 28.19 12.22 37 40613 12433 64445649
Retinal ischaemia 27.76 12.22 12 40638 708 64457374
Eye pruritus 27.75 12.22 37 40613 12622 64445460
Polyneuropathy 27.66 12.22 47 40603 19847 64438235
Treatment failure 27.65 12.22 146 40504 116670 64341412
Obstructive airways disorder 27.38 12.22 51 40599 23134 64434948
Corneal transplant 27.25 12.22 9 40641 250 64457832
Flat anterior chamber of eye 27.14 12.22 8 40642 151 64457931
Forced expiratory volume decreased 26.77 12.22 27 40623 6840 64451242
Optic neuropathy 26.67 12.22 19 40631 2992 64455090
Tendon rupture 25.99 12.22 33 40617 10734 64447348
Maternal exposure during pregnancy 25.98 12.22 14 40636 95870 64362212
Peripheral nerve injury 25.84 12.22 11 40639 625 64457457
Non-infectious endophthalmitis 25.81 12.22 9 40641 296 64457786
Eye abscess 25.78 12.22 9 40641 297 64457785
Acute myeloid leukaemia recurrent 25.66 12.22 18 40632 2766 64455316
Hyperkalaemia 25.65 12.22 16 40634 101113 64356969
Bronchial ulceration 25.48 12.22 4 40646 0 64458082
Metamorphopsia 25.45 12.22 13 40637 1119 64456963
Retinal vasculitis 25.29 12.22 13 40637 1134 64456948
Hypotension 25.25 12.22 139 40511 380835 64077247
Eye oedema 25.08 12.22 15 40635 1758 64456324
Herpes zoster 24.55 12.22 107 40543 79080 64379002
Sleep disorder due to a general medical condition 24.39 12.22 28 40622 8206 64449876
Corynebacterium infection 24.30 12.22 12 40638 961 64457121
Iris adhesions 24.24 12.22 10 40640 525 64457557
Acoustic neuroma 24.00 12.22 8 40642 229 64457853
Cerebrovascular accident 23.86 12.22 31 40619 137552 64320530
Bradycardia 23.35 12.22 24 40626 118195 64339887
Conjunctival oedema 23.29 12.22 12 40638 1052 64457030
Blepharitis allergic 23.24 12.22 4 40646 3 64458079
Sitting disability 22.96 12.22 7 40643 149 64457933
Corneal scar 22.89 12.22 8 40642 265 64457817
Injection site erythema 22.89 12.22 8 40642 70792 64387290
Aortic aneurysm 22.85 12.22 26 40624 7548 64450534
Haemostasis 22.75 12.22 8 40642 270 64457812
Fatigue 22.69 12.22 334 40316 748396 63709686
Acute kidney injury 22.65 12.22 178 40472 449062 64009020
Corneal thinning 22.61 12.22 7 40643 157 64457925
Eye inflammation 22.51 12.22 21 40629 4836 64453246
Lacrimation increased 22.47 12.22 41 40609 18305 64439777
Skin reaction 22.46 12.22 33 40617 12319 64445763
Nosocomial infection 22.45 12.22 16 40634 2521 64455561
Keratic precipitates 22.05 12.22 8 40642 296 64457786
Detachment of retinal pigment epithelium 21.96 12.22 10 40640 668 64457414
Herpes zoster meningoencephalitis 21.79 12.22 10 40640 680 64457402
Eye discharge 21.69 12.22 21 40629 5063 64453019
Rhinitis allergic 21.49 12.22 26 40624 8052 64450030
Necrotising scleritis 21.28 12.22 7 40643 192 64457890
Vanishing bile duct syndrome 21.23 12.22 12 40638 1265 64456817
Intentional product use issue 21.08 12.22 117 40533 95247 64362835
Wound 20.96 12.22 11 40639 76466 64381616
Immune reconstitution inflammatory syndrome associated tuberculosis 20.71 12.22 10 40640 763 64457319
Headache 20.56 12.22 224 40426 529243 63928839
Eye infection staphylococcal 20.52 12.22 6 40644 110 64457972
Productive cough 20.51 12.22 96 40554 73107 64384975
Anterior chamber pigmentation 20.20 12.22 4 40646 11 64458071
Bronchitis 19.92 12.22 127 40523 108616 64349466
Walking aid user 19.70 12.22 22 40628 6259 64451823
Sputum discoloured 19.50 12.22 38 40612 17818 64440264
Vitreal cells 19.46 12.22 5 40645 55 64458027
Mediastinal effusion 19.46 12.22 5 40645 55 64458027
Hepatic steatosis 19.44 12.22 53 40597 30954 64427128
Haematospermia 19.34 12.22 7 40643 257 64457825
Aqueous humour leakage 19.11 12.22 3 40647 0 64458082
Gonioscopy abnormal 19.11 12.22 3 40647 0 64458082
Incorrect product administration duration 19.10 12.22 27 40623 9731 64448351
Nocardiosis 19.05 12.22 19 40631 4748 64453334
Corneal neovascularisation 18.96 12.22 6 40644 145 64457937
Gastroenteritis staphylococcal 18.94 12.22 7 40643 273 64457809
Eye irritation 18.87 12.22 35 40615 15821 64442261
Thrombocytopenia 18.48 12.22 219 40431 223582 64234500
Increased viscosity of bronchial secretion 18.42 12.22 8 40642 477 64457605
Injection site pain 18.41 12.22 26 40624 111382 64346700
Corneal erosion 18.40 12.22 7 40643 296 64457786
Drug ineffective for unapproved indication 18.32 12.22 52 40598 31081 64427001
Morganella infection 18.22 12.22 10 40640 996 64457086
Anterior chamber inflammation 18.17 12.22 8 40642 493 64457589
Caffeine allergy 18.16 12.22 4 40646 21 64458061
Forced vital capacity abnormal 18.16 12.22 4 40646 21 64458061
Axonal neuropathy 18.12 12.22 12 40638 1680 64456402
Oral candidiasis 18.00 12.22 43 40607 23169 64434913
Rash morbilliform 17.85 12.22 19 40631 5122 64452960
Mycobacterium chelonae infection 17.82 12.22 13 40637 2124 64455958
Implant site hypersensitivity 17.71 12.22 4 40646 24 64458058
Language disorder 17.13 12.22 14 40636 2703 64455379
Pericarditis 17.12 12.22 9 40641 62507 64395575
Stevens-Johnson syndrome 17.12 12.22 54 40596 34195 64423887
Phosphorus metabolism disorder 17.03 12.22 3 40647 3 64458079
Vitreous degeneration 16.94 12.22 4 40646 30 64458052
Corneal deposits 16.92 12.22 7 40643 370 64457712
Biopsy colon abnormal 16.88 12.22 5 40645 96 64457986
Pneumothorax 16.72 12.22 43 40607 24255 64433827
Sarcoidosis 16.71 12.22 20 40630 6126 64451956
Cough 16.58 12.22 275 40375 301873 64156209
Eosinophilic pneumonia acute 16.57 12.22 9 40641 878 64457204
Masticatory pain 16.50 12.22 4 40646 34 64458048
Blister 16.49 12.22 16 40634 80951 64377131
Dysmetria 16.48 12.22 9 40641 887 64457195
Multiple sclerosis relapse 16.46 12.22 3 40647 41132 64416950
Lethargy 16.41 12.22 13 40637 72581 64385501
Scleral thinning 16.39 12.22 4 40646 35 64458047
Neoplasm progression 16.37 12.22 3 40647 40961 64417121
Pulmonary venous thrombosis 16.33 12.22 5 40645 108 64457974
Paraneoplastic syndrome 16.33 12.22 9 40641 904 64457178
Anaphylactic shock 16.25 12.22 49 40601 30279 64427803
Back pain 16.16 12.22 92 40558 250079 64208003
Malignant neoplasm progression 16.14 12.22 29 40621 112842 64345240
Vitreous floaters 16.13 12.22 20 40630 6353 64451729
Choroidal neovascularisation 16.06 12.22 7 40643 421 64457661
Toxic optic neuropathy 16.02 12.22 9 40641 938 64457144
Hyperalbuminaemia 15.83 12.22 4 40646 41 64458041
Tuberculosis 15.79 12.22 29 40621 13009 64445073
Eyelid oedema 15.75 12.22 28 40622 12251 64445831
Weight increased 15.72 12.22 75 40575 213273 64244809
Eye infection fungal 15.71 12.22 7 40643 444 64457638
Respiratory moniliasis 15.61 12.22 6 40644 261 64457821
Vitreous haemorrhage 15.58 12.22 14 40636 3071 64455011
Aqueous fibrin 15.53 12.22 5 40645 128 64457954
Macular fibrosis 15.47 12.22 8 40642 706 64457376
Respiratory arrest 15.47 12.22 7 40643 52978 64405104
Incision site pain 15.33 12.22 13 40637 2641 64455441
Cellulitis 15.33 12.22 22 40628 93635 64364447
Ventricular tachycardia 15.30 12.22 52 40598 34213 64423869
Rash erythematous 15.29 12.22 66 40584 48567 64409515
Complications of transplant surgery 15.22 12.22 8 40642 731 64457351
Blood immunoglobulin G decreased 15.21 12.22 13 40637 2670 64455412
Urinary tract infection 15.05 12.22 85 40565 231511 64226571
Nervous system disorder 15.02 12.22 40 40610 23038 64435044
Cutis laxa 14.97 12.22 5 40645 144 64457938
Chondritis 14.87 12.22 5 40645 147 64457935
Suspected counterfeit product 14.84 12.22 7 40643 507 64457575
Anterior chamber flare 14.74 12.22 5 40645 151 64457931
Coronary artery disease 14.72 12.22 10 40640 60423 64397659
Dysdiadochokinesis 14.61 12.22 6 40644 311 64457771
Chest discomfort 14.61 12.22 124 40526 115982 64342100
Injection site swelling 14.57 12.22 4 40646 41349 64416733
AIDS related complication 14.55 12.22 4 40646 58 64458024
Choroidal detachment 14.48 12.22 7 40643 535 64457547
Retinal artery occlusion 14.32 12.22 13 40637 2890 64455192
Anterior chamber fibrin 14.29 12.22 5 40645 166 64457916
Neurilemmoma benign 14.29 12.22 3 40647 12 64458070
Discomfort 14.25 12.22 18 40632 80860 64377222
Erythema of eyelid 14.25 12.22 11 40639 1957 64456125
Embolism venous 14.06 12.22 14 40636 3493 64454589
Haematemesis 14.05 12.22 6 40644 46993 64411089
Muscle spasms 13.97 12.22 44 40606 140979 64317103
Limb mass 13.88 12.22 13 40637 3008 64455074
Disorganised speech 13.68 12.22 10 40640 1640 64456442
Hyperglycaemia 13.68 12.22 11 40639 60957 64397125
Scleral disorder 13.65 12.22 5 40645 190 64457892
Ocular hypertension 13.64 12.22 9 40641 1252 64456830
Sinus pain 13.58 12.22 12 40638 2577 64455505
Cardio-respiratory arrest 13.43 12.22 26 40624 98367 64359715
Bronchopulmonary aspergillosis 13.36 12.22 34 40616 19051 64439031
Foreign body in eye 13.32 12.22 5 40645 204 64457878
Musculoskeletal stiffness 13.24 12.22 37 40613 123169 64334913
Tendon disorder 13.11 12.22 18 40632 6314 64451768
Pain in extremity 13.07 12.22 125 40525 302960 64155122
Gastrointestinal mucosa hyperaemia 12.94 12.22 6 40644 418 64457664
Cryptococcosis 12.94 12.22 12 40638 2743 64455339
Ocular icterus 12.90 12.22 16 40634 5082 64453000
Intentional product misuse 12.83 12.22 16 40634 72279 64385803
Vestibular disorder 12.77 12.22 11 40639 2282 64455800
Hypotony of eye 12.77 12.22 5 40645 229 64457853
Injection site pruritus 12.70 12.22 4 40646 37822 64420260
Skin odour abnormal 12.58 12.22 10 40640 1857 64456225
Disseminated mycobacterium avium complex infection 12.40 12.22 4 40646 103 64457979
Injection site reaction 12.37 12.22 7 40643 46657 64411425
Allergic cough 12.35 12.22 6 40644 464 64457618
Rash 12.31 12.22 377 40273 458172 63999910
FEV1/FVC ratio abnormal 12.22 12.22 3 40647 27 64458055

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC J01MA14 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
QUINOLONE ANTIBACTERIALS
Fluoroquinolones
ATC S01AE07 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFECTIVES
Fluoroquinolones
FDA CS M0023650 Quinolones
MeSH PA D000900 Anti-Bacterial Agents
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000970 Antineoplastic Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D059005 Topoisomerase II Inhibitors
CHEBI has role CHEBI:36047 antibacterial drugs
FDA EPC N0000175937 Quinolone Antimicrobial

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Septicemic plague indication 9012003 DOID:3481
Infection of skin AND/OR subcutaneous tissue indication 19824006
Staphylococcal pneumonia indication 22754005
Pneumonia due to Streptococcus indication 34020007
Pneumonic plague indication 38976008 DOID:10398
Pneumonia due to Mycoplasma pneumoniae indication 46970008
Peritonitis indication 48661000
Bacterial pneumonia indication 53084003 DOID:874
Pneumonia due to Klebsiella pneumoniae indication 64479007
Haemophilus influenzae pneumonia indication 70036007
Rhinoscleroma indication 72409005 DOID:11336
Abdominal abscess indication 75100008
Acute bacterial sinusitis indication 75498004
Infectious disease of abdomen indication 128070006
Bacterial conjunctivitis indication 128350005 DOID:9700
Infection due to Enterobacteriaceae indication 128945009
Bacterial infection due to Klebsiella pneumoniae indication 186435004
Pneumococcal pneumonia indication 233607000
Chlamydial pneumonia indication 233609002
Streptococcus pyogenes infection indication 302809008
Infection due to Staphylococcus aureus indication 406602003
Acute exacerbation of chronic bronchitis indication 425748003
Complicated Skin and Skin Structure E. Coli Infection indication
Complicated Skin and Skin Structure Infection indication
Haemophilus Influenzae Chronic Bronchitis indication
Complicated Skin and Skin Structure Staphylococcus Aureus Infection indication
Haemophilus Parainfluenzae Chronic Bronchitis indication
Streptococcus Pneumoniae Chronic Bronchitis indication
Moraxella Catarrhalis Pneumonia indication
Staphylococcus Chronic Bronchitis indication
Klebsiella Pneumoniae Chronic Bronchitis indication
Moraxella Catarrhalis Chronic Bronchitis indication
Acute tuberculosis off-label use 25629007
Pulmonary tuberculosis off-label use 154283005 DOID:2957
Cirrhosis of liver contraindication 19943007 DOID:5082
Torsades de pointes contraindication 31722008
Transplantation of heart contraindication 32413006
Tendinitis contraindication 34840004 DOID:971
Hypokalemia contraindication 43339004
Conduction disorder of the heart contraindication 44808001
Bradycardia contraindication 48867003
Transplant of kidney contraindication 70536003
Epilepsy contraindication 84757009 DOID:1826
Transplant of lung contraindication 88039007
Myasthenia gravis contraindication 91637004 DOID:437
Prolonged QT interval contraindication 111975006
Liver function tests abnormal contraindication 166603001
Drug-induced hepatitis contraindication 235876009
Peripheral nerve disease contraindication 302226006
Pseudomembranous enterocolitis contraindication 397683000
Myocardial ischemia contraindication 414795007 DOID:3393
Traumatic rupture of tendon contraindication 415749005
Congenital long QT syndrome contraindication 442917000
Severe Cerebral Arteriosclerosis contraindication




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 6.23 acidic
pKa2 8.54 Basic
pKa3 2.92 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Topoisomerase IV Enzyme INHIBITOR CHEMBL CHEMBL
DNA gyrase Enzyme INHIBITOR IC50 6.52 CHEMBL CHEMBL
DNA topoisomerase 4 subunit A Enzyme IC50 6.10 CHEMBL
DNA gyrase subunit A Enzyme IC50 5.04 CHEMBL

External reference:

IDSource
D00874 KEGG_DRUG
186826-86-8 SECONDARY_CAS_RN
4021185 VANDF
4021186 VANDF
C0536495 UMLSCUI
CHEBI:63611 CHEBI
MFX PDB_CHEM_ID
CHEMBL32 ChEMBL_ID
CHEMBL1200735 ChEMBL_ID
D000077266 MESH_DESCRIPTOR_UI
DB00218 DRUGBANK_ID
152946 PUBCHEM_CID
10915 IUPHAR_LIGAND_ID
7659 INN_ID
U188XYD42P UNII
1047505 RXNORM
178916 MMSL
213098 MMSL
31558 MMSL
35332 MMSL
8580 MMSL
d04500 MMSL
007927 NDDF
007928 NDDF
116347002 SNOMEDCT_US
371296007 SNOMEDCT_US
412439003 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
MOXEZA HUMAN PRESCRIPTION DRUG LABEL 1 0065-0006 SOLUTION 5 mg OPHTHALMIC NDA 23 sections
VIGAMOX HUMAN PRESCRIPTION DRUG LABEL 1 0065-4013 SOLUTION/ DROPS 5 mg OPHTHALMIC NDA 25 sections
VIGAMOX HUMAN PRESCRIPTION DRUG LABEL 1 0065-4013 SOLUTION/ DROPS 5 mg OPHTHALMIC NDA 25 sections
VIGAMOX HUMAN PRESCRIPTION DRUG LABEL 1 0078-0939 SOLUTION/ DROPS 5 mg OPHTHALMIC NDA 25 sections
Moxifloxacin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0093-7387 TABLET, FILM COATED 400 mg ORAL ANDA 28 sections
Moxifloxacin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0093-7387 TABLET, FILM COATED 400 mg ORAL ANDA 28 sections
Moxifloxacin HUMAN PRESCRIPTION DRUG LABEL 1 0378-5430 SOLUTION/ DROPS 5 mg OPHTHALMIC ANDA 24 sections
Moxifloxacin Ophthalmic Solution HUMAN PRESCRIPTION DRUG LABEL 1 0781-7135 SOLUTION/ DROPS 5 mg OPHTHALMIC NDA authorized generic 25 sections
Moxifloxacin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0832-1410 SOLUTION 5 mg OPHTHALMIC ANDA 26 sections
Moxifloxacin HUMAN PRESCRIPTION DRUG LABEL 1 0904-6406 TABLET, FILM COATED 400 mg ORAL ANDA 30 sections
Moxifloxacin HUMAN PRESCRIPTION DRUG LABEL 1 0904-6406 TABLET, FILM COATED 400 mg ORAL ANDA 30 sections
moxifloxacin hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 13668-201 TABLET 400 mg ORAL ANDA 29 sections
moxifloxacin hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 13668-201 TABLET 400 mg ORAL ANDA 29 sections
Avelox ABC Pack HUMAN PRESCRIPTION DRUG LABEL 1 16590-881 TABLET, FILM COATED 400 mg ORAL NDA 17 sections
Moxifloxacin HUMAN PRESCRIPTION DRUG LABEL 1 17478-519 SOLUTION/ DROPS 5 mg OPHTHALMIC ANDA 25 sections
VIGAMOX HUMAN PRESCRIPTION DRUG LABEL 1 21695-968 SOLUTION 5 mg OPHTHALMIC NDA 20 sections
Moxifloxacin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 40032-034 TABLET 400 mg ORAL ANDA 28 sections
Moxifloxacin HUMAN PRESCRIPTION DRUG LABEL 1 50090-3147 TABLET, FILM COATED 400 mg ORAL ANDA 30 sections
Moxifloxacin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 50090-4058 TABLET 400 mg ORAL ANDA 32 sections
Moxifloxacin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 50090-4100 TABLET 400 mg ORAL ANDA 32 sections
Moxifloxacin ophthalmic solution Human Prescription Drug Label 1 50090-4781 SOLUTION/ DROPS 5 mg OPHTHALMIC ANDA 24 sections
Moxifloxacin HUMAN PRESCRIPTION DRUG LABEL 1 50090-5279 SOLUTION/ DROPS 5 mg OPHTHALMIC ANDA 24 sections
Moxifloxacin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 50268-576 TABLET, FILM COATED 400 mg ORAL ANDA 30 sections
Moxifloxacin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 50268-576 TABLET, FILM COATED 400 mg ORAL ANDA 30 sections
Moxifloxacin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 51991-943 TABLET 400 mg ORAL ANDA 33 sections
Moxifloxacin ophthalmic solution Human Prescription Drug Label 1 53002-2626 SOLUTION/ DROPS 5 mg OPHTHALMIC ANDA 24 sections
Avelox HUMAN PRESCRIPTION DRUG LABEL 1 54868-4367 TABLET, FILM COATED 400 mg ORAL NDA 30 sections
VIGAMOX HUMAN PRESCRIPTION DRUG LABEL 1 54868-4798 SOLUTION 5 mg OPHTHALMIC NDA 24 sections
Moxifloxacin HUMAN PRESCRIPTION DRUG LABEL 1 55111-112 TABLET, FILM COATED 400 mg ORAL ANDA 30 sections
Moxifloxacin Hydrochloride Human Prescription Drug Label 1 57237-156 TABLET, FILM COATED 400 mg ORAL ANDA 29 sections