moxifloxacin Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antibacterials, nalidixic acid derivatives 1854 151096-09-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • avelox
  • moxifloxacin
  • moxifloxacin hydrochloride
  • avolex
  • moxeza
  • moxifloxacine
  • moxifloxacin HCl
A fluoroquinolone that acts as an inhibitor of DNA TOPOISOMERASE II and is used as a broad-spectrum antibacterial agent.
  • Molecular weight: 401.44
  • Formula: C21H24FN3O4
  • CLOGP: -0.08
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 2
  • TPSA: 82.11
  • ALOGS: -3.38
  • ROTB: 4

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.40 g O
0.40 g P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 27.50 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 22 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 14.23 ┬ÁM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 86 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 1.40 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 2.40 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.60 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 8.20 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Dec. 10, 1999 FDA BAYER HLTHCARE

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Anaphylactic reaction 1652.05 32.75 421 5222 9284 2343158
Rash 1256.36 32.75 529 5114 59029 2293413
Hypersensitivity 1008.16 32.75 352 5291 23241 2329201
Urticaria 975.51 32.75 346 5297 23915 2328527
Pruritus 960.30 32.75 400 5243 42940 2309502
Dyspnoea 934.88 32.75 470 5173 78263 2274179
Dizziness 871.90 32.75 409 5234 58256 2294186
Nausea 726.65 32.75 450 5193 111739 2240703
Drug hypersensitivity 724.72 32.75 336 5307 46307 2306135
Vomiting 593.91 32.75 338 5305 71264 2281178
Anaphylactic shock 534.29 32.75 146 5497 4140 2348302
Erythema 506.69 32.75 218 5425 24941 2327501
Electrocardiogram QT prolonged 496.98 32.75 158 5485 7656 2344786
Paraesthesia 443.13 32.75 191 5452 21897 2330545
Tendonitis 407.78 32.75 103 5540 2124 2350318
Anxiety 382.08 32.75 188 5455 29171 2323271
Palpitations 371.92 32.75 155 5488 16301 2336141
Tremor 338.00 32.75 155 5488 20506 2331936
Diarrhoea 313.16 32.75 241 5402 83323 2269119
Arthralgia 301.02 32.75 199 5444 54086 2298356
Toxic anterior segment syndrome 300.63 32.75 56 5587 237 2352205
Neuropathy peripheral 300.16 32.75 120 5523 11312 2341130
Swelling face 289.19 32.75 111 5532 9382 2343060
Hypoaesthesia 258.15 32.75 128 5515 20087 2332355
Loss of consciousness 246.04 32.75 121 5522 18646 2333796
Pain 243.41 32.75 184 5459 61673 2290769
Torsade de pointes 240.45 32.75 68 5575 2178 2350264
Tendon pain 238.44 32.75 53 5590 610 2351832
Tachycardia 236.78 32.75 113 5530 16296 2336146
Pyrexia 220.56 32.75 164 5479 53544 2298898
Lip swelling 219.94 32.75 76 5567 4745 2347697
Asthenia 219.29 32.75 155 5488 46771 2305671
Throat tightness 218.24 32.75 74 5569 4362 2348080
Myalgia 215.63 32.75 119 5524 23214 2329228
Tendon rupture 199.50 32.75 54 5589 1464 2350978
Pain in extremity 197.46 32.75 140 5503 42400 2310042
Oedema peripheral 194.64 32.75 112 5531 23651 2328791
Hypotension 191.63 32.75 124 5519 32312 2320130
Heart rate increased 186.50 32.75 85 5558 11020 2341422
Swollen tongue 186.20 32.75 69 5574 5274 2347168
Drug intolerance 184.27 32.75 90 5553 13627 2338815
Syncope 177.93 32.75 94 5549 16781 2335661
Headache 174.56 32.75 170 5473 80009 2272433
Chest discomfort 164.40 32.75 85 5558 14510 2337932
Mental disorder 162.92 32.75 58 5585 3949 2348493
Vision blurred 155.42 32.75 82 5561 14586 2337856
Burning sensation 154.09 32.75 67 5576 7761 2344681
Insomnia 153.19 32.75 99 5544 25688 2326754
Pharyngeal oedema 151.29 32.75 53 5590 3440 2349002
Ocular hyperaemia 150.97 32.75 55 5588 4001 2348441
Hyperhidrosis 145.99 32.75 80 5563 15342 2337100
Confusional state 145.91 32.75 94 5549 24250 2328192
Rash erythematous 143.78 32.75 59 5584 5917 2346525
Contrast media allergy 142.59 32.75 29 5614 209 2352233
Malaise 142.08 32.75 129 5514 55456 2296986
Swelling 141.62 32.75 80 5563 16270 2336172
Feeling abnormal 141.19 32.75 91 5552 23490 2328952
Abdominal pain 140.80 32.75 105 5538 34269 2318173
Hallucination 138.72 32.75 63 5580 8085 2344357
Muscular weakness 132.01 32.75 74 5569 14823 2337619
Eye pain 130.42 32.75 52 5591 4839 2347603
Joint swelling 126.26 32.75 75 5568 16744 2335698
Nervous system disorder 126.25 32.75 45 5598 3071 2349371
Blood pressure decreased 125.14 32.75 61 5582 9175 2343267
Eye swelling 121.67 32.75 48 5595 4342 2348100
Hypopyon 121.38 32.75 24 5619 147 2352295
Nervousness 120.63 32.75 50 5593 5139 2347303
Disorientation 120.37 32.75 53 5590 6319 2346123
Treatment failure 120.15 32.75 55 5588 7184 2345258
Chest pain 119.75 32.75 88 5555 28049 2324393
Speech disorder 119.64 32.75 53 5590 6411 2346031
Visual impairment 119.62 32.75 64 5579 11691 2340751
Iris transillumination defect 117.42 32.75 17 5626 2 2352440
Angioedema 115.38 32.75 56 5587 8340 2344102
Cardiac arrest 113.15 32.75 67 5576 14863 2337579
Ventricular tachycardia 112.66 32.75 41 5602 2970 2349472
Stevens-Johnson syndrome 112.56 32.75 45 5598 4214 2348228
Musculoskeletal injury 111.09 32.75 18 5625 24 2352418
Drug resistance 110.49 32.75 39 5604 2585 2349857
Thrombocytopenia 109.96 32.75 72 5571 19059 2333383
Corneal oedema 109.47 32.75 25 5618 327 2352115
Drug ineffective 107.96 32.75 149 5494 101475 2250967
Corneal epithelium defect 107.43 32.75 20 5623 84 2352358
Fatigue 106.37 32.75 135 5508 84738 2267704
Visual acuity reduced 106.35 32.75 46 5597 5252 2347190
Drug reaction with eosinophilia and systemic symptoms 104.55 32.75 46 5597 5472 2346970
Pneumonia 104.04 32.75 103 5540 49193 2303249
Photophobia 103.98 32.75 36 5607 2253 2350189
Endophthalmitis 103.45 32.75 28 5615 757 2351685
Tendon disorder 102.38 32.75 28 5615 788 2351654
Wheezing 101.23 32.75 47 5596 6337 2346105
Abdominal discomfort 101.04 32.75 66 5577 17390 2335052
Flushing 99.80 32.75 57 5586 11814 2340628
Seizure 96.19 32.75 73 5570 24393 2328049
Clostridium difficile colitis 95.60 32.75 33 5610 2046 2350396
Corneal infiltrates 95.03 32.75 17 5626 54 2352388
Ulcerative keratitis 92.53 32.75 24 5619 548 2351894
Bronchitis 89.64 32.75 56 5587 13658 2338784
Hepatitis 89.25 32.75 43 5600 6294 2346148
Eye irritation 85.54 32.75 35 5608 3477 2348965
Rash macular 85.36 32.75 35 5608 3496 2348946
Cough 84.66 32.75 77 5566 33040 2319402
Delirium 84.50 32.75 39 5604 5184 2347258
Arrhythmia 82.17 32.75 40 5603 5988 2346454
Muscle spasms 81.79 32.75 63 5580 21503 2330939
Hypertension 80.68 32.75 69 5574 27292 2325150
Feeling hot 79.78 32.75 41 5602 6887 2345555
Gait disturbance 79.31 32.75 63 5580 22482 2329960
Tinnitus 78.90 32.75 37 5606 5098 2347344
Toxic epidermal necrolysis 78.85 32.75 32 5611 3112 2349330
Chills 78.44 32.75 54 5589 15498 2336944
Abdominal pain upper 78.26 32.75 62 5581 22038 2330404
Panic attack 78.24 32.75 34 5609 3922 2348520
Dysphagia 77.96 32.75 50 5593 12755 2339687
International normalised ratio increased 77.57 32.75 41 5602 7295 2345147
Cardiovascular disorder 76.81 32.75 29 5614 2326 2350116
Eye pruritus 74.78 32.75 29 5614 2502 2349940
Dysgeusia 72.09 32.75 41 5602 8418 2344024
Skin injury 71.71 32.75 17 5626 264 2352178
Hepatic enzyme increased 71.63 32.75 43 5600 9759 2342683
Injury 70.76 32.75 36 5607 5918 2346524
Dry mouth 70.33 32.75 40 5603 8213 2344229
Anterior chamber cell 69.00 32.75 13 5630 59 2352383
Hypoaesthesia oral 67.98 32.75 26 5617 2160 2350282
Off label use 67.77 32.75 101 5542 73497 2278945
Decreased appetite 67.66 32.75 64 5579 28827 2323615
Paraesthesia oral 66.77 32.75 26 5617 2268 2350174
Vertigo 65.56 32.75 40 5603 9344 2343098
Upper respiratory tract infection 65.12 32.75 39 5604 8812 2343630
Aspartate aminotransferase increased 64.07 32.75 44 5599 12568 2339874
Punctate keratitis 63.94 32.75 14 5629 149 2352293
Depression 63.37 32.75 61 5582 28071 2324371
Emotional distress 63.07 32.75 30 5613 4265 2348177
Hepatotoxicity 62.64 32.75 28 5615 3453 2348989
Vitritis 62.25 32.75 14 5629 170 2352272
Weight decreased 61.06 32.75 60 5583 28311 2324131
Hallucination, visual 60.20 32.75 26 5617 2953 2349489
Restlessness 58.36 32.75 29 5614 4534 2347908
Obliterative bronchiolitis 58.03 32.75 14 5629 235 2352207
Alanine aminotransferase increased 57.59 32.75 43 5600 13989 2338453
Obstructive airways disorder 56.24 32.75 20 5623 1353 2351089
Face oedema 56.21 32.75 27 5616 3921 2348521
Jaundice 56.00 32.75 30 5613 5478 2346964
Cyanosis 55.33 32.75 25 5618 3160 2349282
Liver function test abnormal 55.08 32.75 33 5610 7457 2344985
Hyperventilation 54.53 32.75 19 5624 1210 2351232
Conjunctival hyperaemia 54.42 32.75 16 5627 587 2351855
Vasculitis 52.71 32.75 22 5621 2296 2350146
Suicidal ideation 52.37 32.75 37 5606 11050 2341392
Disturbance in attention 52.35 32.75 29 5614 5656 2346786
Respiratory distress 52.32 32.75 28 5615 5101 2347341
Multiple organ dysfunction syndrome 51.91 32.75 32 5611 7609 2344833
Cold sweat 51.79 32.75 21 5622 2036 2350406
White blood cell count increased 51.57 32.75 31 5612 7047 2345395
Hypokalaemia 51.36 32.75 36 5607 10618 2341824
Pulse absent 51.07 32.75 17 5626 942 2351500
Serum sickness 50.97 32.75 15 5628 552 2351890
Acute kidney injury 50.56 32.75 54 5589 28068 2324374
Aphasia 50.55 32.75 27 5616 4901 2347541
Bronchospasm 50.21 32.75 23 5620 3001 2349441
Eyelid oedema 50.06 32.75 22 5621 2604 2349838
Sinusitis 49.32 32.75 42 5601 16484 2335958
Pathogen resistance 49.13 32.75 16 5627 827 2351615
Musculoskeletal pain 48.53 32.75 35 5608 10795 2341647
Blood pressure increased 48.31 32.75 42 5601 16944 2335498
Anaphylactoid reaction 47.21 32.75 16 5627 937 2351505
Oxygen saturation decreased 47.08 32.75 30 5613 7556 2344886
Ventricular fibrillation 47.07 32.75 20 5623 2181 2350261
Purpura senile 47.03 32.75 8 5635 17 2352425
Infusion related reaction 46.98 32.75 33 5610 9763 2342679
Skin lesion 46.84 32.75 24 5619 4001 2348441
Intentional product use issue 46.38 32.75 23 5620 3579 2348863
Anaemia 46.00 32.75 57 5586 34735 2317707
Blood potassium decreased 45.96 32.75 26 5617 5279 2347163
Clostridial infection 45.81 32.75 15 5628 789 2351653
Dyskinesia 45.66 32.75 25 5618 4764 2347678
Crying 44.84 32.75 24 5619 4372 2348070
Mydriasis 43.63 32.75 19 5624 2200 2350242
Acute hepatic failure 43.56 32.75 20 5623 2622 2349820
Palmar erythema 43.09 32.75 11 5632 235 2352207
Feeling jittery 42.80 32.75 18 5625 1914 2350528
Asthma 42.72 32.75 33 5610 11281 2341161
Tarsal tunnel syndrome 42.70 32.75 8 5635 35 2352407
Blister 42.57 32.75 27 5616 6744 2345698
Ventricular extrasystoles 42.49 32.75 18 5625 1948 2350494
Skin reaction 42.22 32.75 18 5625 1979 2350463
Ototoxicity 42.08 32.75 11 5632 259 2352183
Heart rate irregular 42.00 32.75 19 5624 2408 2350034
Neck pain 41.80 32.75 28 5615 7669 2344773
Eosinophilic pneumonia acute 41.52 32.75 9 5634 91 2352351
Agitation 41.22 32.75 32 5611 11019 2341423
Foreign body sensation in eyes 41.13 32.75 12 5631 428 2352014
Drug interaction 40.52 32.75 49 5594 29114 2323328
Intra-abdominal haematoma 40.40 32.75 11 5632 304 2352138
Incoherent 40.03 32.75 14 5629 901 2351541
Adverse drug reaction 39.94 32.75 28 5615 8255 2344187
Circulatory collapse 39.89 32.75 21 5622 3699 2348743
Renal failure 39.75 32.75 38 5605 17311 2335131
Throat irritation 39.16 32.75 23 5620 5007 2347435
Ear pruritus 38.70 32.75 11 5632 357 2352085
No adverse event 38.64 32.75 29 5614 9499 2342943
Diplopia 38.41 32.75 20 5623 3445 2348997
Mobility decreased 38.39 32.75 28 5615 8782 2343660
Glaucoma 38.16 32.75 17 5626 2078 2350364
Herpes zoster 38.11 32.75 29 5614 9696 2342746
Gait inability 38.07 32.75 24 5619 5931 2346511
Respiratory failure 37.55 32.75 33 5610 13495 2338947
Hypoglycaemia 37.27 32.75 27 5616 8380 2344062
Rash maculo-papular 37.26 32.75 21 5622 4231 2348211
Adverse event 37.18 32.75 26 5617 7633 2344809
Peripheral nerve injury 36.80 32.75 8 5635 82 2352360
Dysphonia 36.61 32.75 24 5619 6340 2346102
Anterior chamber disorder 36.43 32.75 7 5636 36 2352406
Musculoskeletal stiffness 36.27 32.75 31 5612 12216 2340226
Thinking abnormal 36.14 32.75 16 5627 1926 2350516
Paradoxical drug reaction 35.98 32.75 11 5632 462 2351980
Physical disability 35.91 32.75 9 5634 178 2352264
Corneal opacity 34.88 32.75 9 5634 201 2352241
Respiratory arrest 34.81 32.75 23 5620 6155 2346287
Hepatic failure 34.06 32.75 22 5621 5667 2346775
Oedema mouth 34.03 32.75 12 5631 791 2351651
Lymphadenopathy 34.03 32.75 22 5621 5676 2346766
Sleep disorder 33.79 32.75 23 5620 6466 2345976
Balance disorder 33.71 32.75 27 5616 9720 2342722
Skin exfoliation 33.71 32.75 22 5621 5768 2346674
Discomfort 33.50 32.75 21 5622 5138 2347304
Tongue discolouration 33.37 32.75 11 5632 591 2351851
Loss of employment 33.29 32.75 8 5635 132 2352310
Lacrimation increased 33.29 32.75 17 5626 2813 2349629
Dry eye 33.22 32.75 19 5624 3937 2348505
Limb discomfort 33.21 32.75 18 5625 3361 2349081
Anosmia 33.07 32.75 12 5631 860 2351582
Rheumatoid arthritis 33.05 32.75 36 5607 19104 2333338
Mycobacterium avium complex infection 32.84 32.75 10 5633 414 2352028
Psychotic disorder 32.80 32.75 20 5623 4659 2347783

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Anaphylactic reaction 844.35 34.52 228 3415 5885 1737253
Pruritus 495.39 34.52 213 3430 23009 1720129
Rash 448.87 34.52 233 3410 38460 1704678
Hypersensitivity 427.94 34.52 154 3489 10290 1732848
Urticaria 414.98 34.52 157 3486 12084 1731054
Dyspnoea 378.96 34.52 231 3412 51828 1691310
Electrocardiogram QT prolonged 373.92 34.52 119 3524 5426 1737712
Tendonitis 306.40 34.52 76 3567 1357 1741781
Tendon rupture 295.21 34.52 77 3566 1695 1741443
Anaphylactic shock 249.03 34.52 75 3568 2824 1740314
Neuropathy peripheral 240.05 34.52 98 3545 9155 1733983
Erythema 224.20 34.52 106 3537 14082 1729056
Dizziness 222.12 34.52 142 3501 34219 1708919
Arthralgia 187.15 34.52 111 3532 23333 1719805
Mental disorder 187.06 34.52 60 3583 2783 1740355
Tendon pain 171.68 34.52 39 3604 465 1742673
Swelling face 171.34 34.52 63 3580 4420 1738718
Delirium 149.94 34.52 63 3580 6299 1736839
Paraesthesia 143.43 34.52 71 3572 10380 1732758
Pyrexia 137.09 34.52 120 3523 46280 1696858
Toxic anterior segment syndrome 135.03 34.52 27 3616 164 1742974
Drug hypersensitivity 134.66 34.52 77 3566 15058 1728080
Pain in extremity 133.08 34.52 82 3561 18390 1724748
Vomiting 131.36 34.52 108 3535 38207 1704931
Confusional state 129.75 34.52 85 3558 21193 1721945
Loss of consciousness 127.84 34.52 74 3569 14801 1728337
Hypotension 126.18 34.52 95 3548 29559 1713579
Hepatotoxicity 123.93 34.52 45 3598 3039 1740099
Pain 121.44 34.52 89 3554 26568 1716570
Lip swelling 120.64 34.52 43 3600 2752 1740386
Visual acuity reduced 117.30 34.52 46 3597 3842 1739296
Hypoaesthesia 115.02 34.52 60 3583 9775 1733363
Tendon disorder 113.34 34.52 28 3615 488 1742650
Blood pressure decreased 110.97 34.52 54 3589 7592 1735546
Swelling 109.37 34.52 52 3591 6944 1736194
Nausea 108.13 34.52 110 3533 51086 1692052
Diarrhoea 107.06 34.52 112 3531 53740 1689398
Torsade de pointes 103.92 34.52 32 3611 1292 1741846
Oedema peripheral 101.77 34.52 65 3578 15485 1727653
Hallucination 101.72 34.52 52 3591 8118 1735020
Musculoskeletal injury 99.69 34.52 16 3627 17 1743121
Drug resistance 96.65 34.52 38 3605 3192 1739946
Hyperhidrosis 96.39 34.52 58 3585 12430 1730708
Tremor 93.70 34.52 58 3585 13073 1730065
Asthenia 92.87 34.52 85 3558 34585 1708553
Swollen tongue 90.97 34.52 35 3608 2773 1740365
Ulcerative keratitis 90.39 34.52 22 3621 359 1742779
Clostridium difficile colitis 89.85 34.52 30 3613 1574 1741564
Jaundice 88.48 34.52 43 3600 6019 1737119
Condition aggravated 88.11 34.52 67 3576 21083 1722055
Anxiety 87.20 34.52 59 3584 15468 1727670
Product use in unapproved indication 86.53 34.52 49 3594 9373 1733765
Skin injury 86.46 34.52 19 3624 192 1742946
Eye pain 86.17 34.52 32 3611 2299 1740839
Burning sensation 86.17 34.52 35 3608 3200 1739938
Nervous system disorder 84.57 34.52 32 3611 2422 1740716
Flushing 84.08 34.52 42 3601 6237 1736901
Corneal oedema 82.95 34.52 20 3623 313 1742825
Myalgia 82.01 34.52 57 3586 15601 1727537
Iris transillumination defect 81.59 34.52 12 3631 2 1743136
Endophthalmitis 81.13 34.52 23 3620 693 1742445
Multiple-drug resistance 79.18 34.52 19 3624 291 1742847
Aspartate aminotransferase increased 77.94 34.52 48 3595 10708 1732430
Off label use 76.04 34.52 80 3563 38491 1704647
Angioedema 74.82 34.52 45 3598 9619 1733519
Chest discomfort 72.39 34.52 40 3603 7291 1735847
Intraocular pressure increased 69.78 34.52 23 3620 1158 1741980
Palpitations 69.54 34.52 38 3605 6776 1736362
Arrhythmia 68.25 34.52 36 3607 5980 1737158
Pneumonia 67.51 34.52 82 3561 46100 1697038
Alanine aminotransferase increased 67.33 34.52 46 3597 12232 1730906
Emotional distress 66.55 34.52 25 3618 1853 1741285
Seizure 66.40 34.52 56 3587 20385 1722753
Insomnia 64.30 34.52 50 3593 16226 1726912
Intentional product use issue 64.21 34.52 27 3616 2692 1740446
Mycobacterial infection 64.20 34.52 16 3627 289 1742849
Abdominal pain 63.97 34.52 56 3587 21434 1721704
Vision blurred 59.50 34.52 37 3606 8386 1734752
Throat tightness 59.22 34.52 22 3621 1580 1741558
Cardiac arrest 58.75 34.52 47 3596 15883 1727255
Pharyngeal oedema 58.55 34.52 22 3621 1631 1741507
Hepatic failure 57.68 34.52 32 3611 5871 1737267
Syncope 56.97 34.52 44 3599 14125 1729013
Corneal infiltrates 56.63 34.52 11 3632 56 1743082
Uveitis 56.24 34.52 19 3624 1032 1742106
Stevens-Johnson syndrome 55.62 34.52 26 3617 3331 1739807
Injury 55.55 34.52 25 3618 2935 1740203
Hypopyon 55.45 34.52 12 3631 112 1743026
Chills 50.74 34.52 38 3605 11649 1731489
Cardiovascular disorder 49.27 34.52 22 3621 2535 1740603
Muscular weakness 48.26 34.52 35 3608 10214 1732924
Decreased appetite 47.79 34.52 50 3593 23821 1719317
Ocular hyperaemia 47.58 34.52 20 3623 1990 1741148
Wheezing 47.50 34.52 25 3618 4128 1739010
Bradycardia 47.40 34.52 35 3608 10499 1732639
Drug ineffective 47.11 34.52 82 3561 63719 1679419
Iridocyclitis 46.44 34.52 13 3630 373 1742765
Chest pain 45.86 34.52 45 3598 19869 1723269
Photophobia 45.80 34.52 17 3626 1217 1741921
Renal failure 45.66 34.52 45 3598 19972 1723166
Tuberculosis 45.62 34.52 19 3624 1847 1741291
Dysphoria 45.51 34.52 15 3628 754 1742384
Hypoglycaemia 44.77 34.52 31 3612 8407 1734731
Deafness 44.67 34.52 19 3624 1947 1741191
Acute kidney injury 44.51 34.52 58 3585 34886 1708252
Drug-induced liver injury 44.32 34.52 22 3621 3215 1739923
Pathogen resistance 44.11 34.52 16 3627 1073 1742065
Keratitis fungal 43.17 34.52 8 3635 30 1743108
Liver function test abnormal 42.57 34.52 26 3617 5700 1737438
Malaise 42.28 34.52 52 3591 29513 1713625
Coma 41.65 34.52 28 3615 7234 1735904
Tinnitus 41.64 34.52 21 3622 3174 1739964
Hepatic enzyme increased 41.54 34.52 27 3616 6594 1736544
Conjunctival hyperaemia 41.49 34.52 13 3630 555 1742583
Conjunctivitis 41.22 34.52 17 3626 1612 1741526
Ventricular tachycardia 41.00 34.52 22 3621 3776 1739362
Corneal opacity 40.74 34.52 10 3633 169 1742969
Drug eruption 40.39 34.52 20 3623 2906 1740232
Respiratory distress 39.83 34.52 24 3619 5133 1738005
Choroiditis 39.26 34.52 8 3635 54 1743084
Cyanosis 39.07 34.52 19 3624 2655 1740483
Clostridial infection 38.65 34.52 13 3630 696 1742442
Restlessness 38.34 34.52 22 3621 4299 1738839
Eye swelling 38.28 34.52 17 3626 1932 1741206
International normalised ratio increased 38.28 34.52 28 3615 8271 1734867
Abdominal discomfort 38.23 34.52 29 3614 9052 1734086
Thrombocytopenia 38.09 34.52 42 3601 21207 1721931
Tachycardia 37.70 34.52 33 3610 12595 1730543
Tubulointerstitial nephritis 37.25 34.52 19 3624 2939 1740199
Rhabdomyolysis 37.22 34.52 31 3612 11059 1732079
Atrial fibrillation 36.37 34.52 35 3608 15076 1728062
Diastasis recti abdominis 36.22 34.52 6 3637 9 1743129
Clostridium test positive 36.09 34.52 10 3633 276 1742862
Visual impairment 35.72 34.52 24 3619 6194 1736944
Hepatitis 35.55 34.52 22 3621 4933 1738205
Dysgeusia 35.17 34.52 22 3621 5027 1738111
Infusion site erythema 34.77 34.52 10 3633 317 1742821
Urethritis mycoplasmal 34.76 34.52 5 3638 0 1743138
Headache 34.66 34.52 51 3592 34325 1708813

Pharmacologic Action:

SourceCodeDescription
ATC J01MA14 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
QUINOLONE ANTIBACTERIALS
Fluoroquinolones
ATC S01AE07 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFECTIVES
Fluoroquinolones
FDA EPC N0000175937 Quinolone Antimicrobial
FDA Chemical/Ingredient N0000007606 Quinolones
MeSH PA D000900 Anti-Bacterial Agents
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000970 Antineoplastic Agents
MeSH PA D004791 Enzyme Inhibitors
CHEBI has role CHEBI:36047 antibacterial drug
MeSH PA D059005 Topoisomerase II Inhibitors

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Septicemic plague indication 9012003 DOID:3481
Infection of skin AND/OR subcutaneous tissue indication 19824006
Staphylococcal pneumonia indication 22754005
Pneumonia due to Streptococcus indication 34020007
Pneumonic plague indication 38976008 DOID:10398
Pneumonia due to Mycoplasma pneumoniae indication 46970008
Peritonitis indication 48661000
Bacterial pneumonia indication 53084003 DOID:874
Pneumonia due to Klebsiella pneumoniae indication 64479007
Haemophilus influenzae pneumonia indication 70036007
Rhinoscleroma indication 72409005 DOID:11336
Abdominal abscess indication 75100008
Acute bacterial sinusitis indication 75498004
Infectious disease of abdomen indication 128070006
Bacterial conjunctivitis indication 128350005 DOID:9700
Infection due to Enterobacteriaceae indication 128945009
Bacterial infection due to Klebsiella pneumoniae indication 186435004
Pneumococcal pneumonia indication 233607000
Chlamydial pneumonia indication 233609002
Streptococcus pyogenes infection indication 302809008
Infection due to Staphylococcus aureus indication 406602003
Acute exacerbation of chronic bronchitis indication 425748003
Complicated Skin and Skin Structure E. Coli Infection indication
Complicated Skin and Skin Structure Infection indication
Haemophilus Influenzae Chronic Bronchitis indication
Complicated Skin and Skin Structure Staphylococcus Aureus Infection indication
Haemophilus Parainfluenzae Chronic Bronchitis indication
Streptococcus Pneumoniae Chronic Bronchitis indication
Moraxella Catarrhalis Pneumonia indication
Staphylococcus Chronic Bronchitis indication
Klebsiella Pneumoniae Chronic Bronchitis indication
Moraxella Catarrhalis Chronic Bronchitis indication
Acute tuberculosis off-label use 25629007
Pulmonary tuberculosis off-label use 154283005 DOID:2957
Cirrhosis of liver contraindication 19943007 DOID:5082
Torsades de pointes contraindication 31722008
Transplantation of heart contraindication 32413006
Tendinitis contraindication 34840004 DOID:971
Hypokalemia contraindication 43339004
Conduction disorder of the heart contraindication 44808001
Bradycardia contraindication 48867003
Transplant of kidney contraindication 70536003
Epilepsy contraindication 84757009 DOID:1826
Transplant of lung contraindication 88039007
Myasthenia gravis contraindication 91637004 DOID:437
Prolonged QT interval contraindication 111975006
Liver function tests abnormal contraindication 166603001
Drug-induced hepatitis contraindication 235876009
Peripheral nerve disease contraindication 302226006
Pseudomembranous enterocolitis contraindication 397683000
Myocardial ischemia contraindication 414795007 DOID:3393
Traumatic rupture of tendon contraindication 415749005
Congenital long QT syndrome contraindication 442917000
Severe Cerebral Arteriosclerosis contraindication

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 6.23 acidic
pKa2 8.54 Basic
pKa3 2.92 Basic

Orange Book patent data (new drug applications)

Formulation strengthTrade nameApplicantApplication numberApproval dateTypeDose formRoutePatent numberPatent expiration datePatent use
400MG/250ML (1.6MG/ML) **Federal Register determination that product was not discontinued or withdrawn for safety or efficacy reasons** AVELOX IN SODIUM CHLORIDE 0.8% IN PLASTIC CONTAINER BAYER HLTHCARE N021277 Nov. 30, 2001 DISCN SOLUTION INTRAVENOUS 6548079 July 25, 2020 METHOD OF COMBATING BACTERIA IN A PATIENT

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
DNA gyrase Enzyme INHIBITOR IC50 6.52 CHEMBL CHEMBL
Topoisomerase IV Enzyme INHIBITOR CHEMBL CHEMBL
DNA topoisomerase 4 subunit A Enzyme IC50 6.10 CHEMBL
DNA gyrase subunit A Enzyme IC50 5.04 CHEMBL

External reference:

IDSource
D000077266 MESH_DESCRIPTOR_UI
C0875968 UMLSCUI
D00874 KEGG_DRUG
371296007 SNOMEDCT_US
007927 NDDF
d04500 MMSL
139462 RXNORM
4021185 VANDF
412439003 SNOMEDCT_US
C53598599T UNII
186826-86-8 SECONDARY_CAS_RN
CHEMBL32 ChEMBL_ID
DB00218 DRUGBANK_ID
CHEMBL1200735 ChEMBL_ID
7659 INN_ID
MFX PDB_CHEM_ID
CHEBI:63611 CHEBI
152946 PUBCHEM_CID

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
MOXEZA HUMAN PRESCRIPTION DRUG LABEL 1 0065-0006 SOLUTION 5 mg OPHTHALMIC NDA 14 sections
VIGAMOX HUMAN PRESCRIPTION DRUG LABEL 1 0065-4013 SOLUTION/ DROPS 5 mg OPHTHALMIC NDA 15 sections
Moxifloxacin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0093-7387 TABLET, FILM COATED 400 mg ORAL ANDA 19 sections
Moxifloxacin Ophthalmic Solution HUMAN PRESCRIPTION DRUG LABEL 1 0781-7135 SOLUTION/ DROPS 5 mg OPHTHALMIC NDA authorized generic 15 sections
Moxifloxacin HUMAN PRESCRIPTION DRUG LABEL 1 0904-6406 TABLET, FILM COATED 400 mg ORAL ANDA 20 sections
moxifloxacin hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 13668-201 TABLET 400 mg ORAL ANDA 20 sections
Avelox ABC Pack HUMAN PRESCRIPTION DRUG LABEL 1 16590-881 TABLET, FILM COATED 400 mg ORAL NDA 17 sections
Moxifloxacin HUMAN PRESCRIPTION DRUG LABEL 1 17478-519 SOLUTION/ DROPS 5 mg OPHTHALMIC ANDA 15 sections
VIGAMOX HUMAN PRESCRIPTION DRUG LABEL 1 21695-968 SOLUTION 5 mg OPHTHALMIC NDA 13 sections
Moxifloxacin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 40032-034 TABLET 400 mg ORAL ANDA 20 sections
Moxifloxacin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 47781-268 TABLET, FILM COATED 400 mg ORAL NDA authorized generic 20 sections
Moxifloxacin HUMAN PRESCRIPTION DRUG LABEL 1 48792-7823 TABLET, FILM COATED 400 mg ORAL ANDA 18 sections
VIGAMOX HUMAN PRESCRIPTION DRUG LABEL 1 50090-0859 SOLUTION/ DROPS 5 mg OPHTHALMIC NDA 15 sections
Moxifloxacin HUMAN PRESCRIPTION DRUG LABEL 1 50090-3147 TABLET, FILM COATED 400 mg ORAL ANDA 20 sections
Moxifloxacin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 50090-4058 TABLET 400 mg ORAL ANDA 20 sections
Moxifloxacin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 50090-4100 TABLET 400 mg ORAL ANDA 20 sections
Moxifloxacin ophthalmic solution HUMAN PRESCRIPTION DRUG LABEL 1 50090-4781 SOLUTION/ DROPS 5 mg OPHTHALMIC ANDA 15 sections
Moxifloxacin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 50268-576 TABLET, FILM COATED 400 mg ORAL ANDA 21 sections
Avelox HUMAN PRESCRIPTION DRUG LABEL 1 50419-530 TABLET, FILM COATED 400 mg ORAL NDA 20 sections
Avelox HUMAN PRESCRIPTION DRUG LABEL 1 50419-537 INJECTION, SOLUTION 400 mg INTRAVENOUS NDA 20 sections
Moxifloxacin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 51991-943 TABLET 400 mg ORAL ANDA 20 sections
Avelox HUMAN PRESCRIPTION DRUG LABEL 1 54868-4367 TABLET, FILM COATED 400 mg ORAL NDA 21 sections
VIGAMOX HUMAN PRESCRIPTION DRUG LABEL 1 54868-4798 SOLUTION 5 mg OPHTHALMIC NDA 15 sections
Moxifloxacin HUMAN PRESCRIPTION DRUG LABEL 1 55111-112 TABLET, FILM COATED 400 mg ORAL ANDA 20 sections
Moxifloxacin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 57237-156 TABLET, FILM COATED 400 mg ORAL ANDA 19 sections
Moxifloxacin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 60429-893 TABLET 400 mg ORAL ANDA 20 sections
Moxifloxacin ophthalmic solution HUMAN PRESCRIPTION DRUG LABEL 1 62332-505 SOLUTION/ DROPS 5 mg OPHTHALMIC ANDA 15 sections
Moxifloxacin HUMAN PRESCRIPTION DRUG LABEL 1 63323-850 INJECTION, SOLUTION 400 mg INTRAVENOUS NDA 19 sections
MOXIFLOXACIN HYDROCHLORIDE HUMAN PRESCRIPTION DRUG LABEL 1 65862-603 TABLET, FILM COATED 400 mg ORAL ANDA 19 sections
MOXIFLOXACIN HUMAN PRESCRIPTION DRUG LABEL 1 65862-840 SOLUTION/ DROPS 5 mg OPHTHALMIC ANDA 15 sections