moxifloxacin ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antibacterials, nalidixic acid derivatives 1854 151096-09-2

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • avelox
  • moxifloxacin
  • moxifloxacin hydrochloride
  • avolex
  • moxeza
  • moxifloxacine
  • moxifloxacin HCl
A fluoroquinolone that acts as an inhibitor of DNA TOPOISOMERASE II and is used as a broad-spectrum antibacterial agent.
  • Molecular weight: 401.44
  • Formula: C21H24FN3O4
  • CLOGP: -0.12
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 2
  • TPSA: 82.11
  • ALOGS: -3.38
  • ROTB: 4

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
0.40 g O
0.40 g P

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 3 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 27.50 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 22 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 14.23 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 86 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 1.40 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 2.40 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.60 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 8.20 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Dec. 10, 1999 FDA BAYER HLTHCARE

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug hypersensitivity 433.28 12.67 718 37883 309969 63140452
Iris transillumination defect 310.60 12.67 54 38547 50 63450371
Contrast media allergy 299.08 12.67 94 38507 2307 63448114
Toxic anterior segment syndrome 265.80 12.67 80 38521 1691 63448730
Endophthalmitis 192.48 12.67 75 38526 3517 63446904
Corneal oedema 175.79 12.67 56 38545 1437 63448984
Drug resistance 161.08 12.67 124 38477 22809 63427612
Asthma 158.84 12.67 281 38320 127280 63323141
Asthma-chronic obstructive pulmonary disease overlap syndrome 158.08 12.67 56 38545 2005 63448416
Hypopyon 154.01 12.67 43 38558 689 63449732
Total lung capacity increased 140.86 12.67 53 38548 2257 63448164
Wheezing 132.64 12.67 221 38380 95374 63355047
Obliterative bronchiolitis 131.15 12.67 49 38552 2046 63448375
Electrocardiogram QT prolonged 130.95 12.67 171 38430 59359 63391062
Loss of employment 117.22 12.67 46 38555 2198 63448223
Torsade de pointes 115.83 12.67 82 38519 13269 63437152
Nasal polyps 105.78 12.67 58 38543 5981 63444440
Corneal opacity 104.80 12.67 32 38569 711 63449710
Upper respiratory tract infection 101.09 12.67 180 38421 81867 63368554
Corneal infiltrates 99.99 12.67 22 38579 120 63450301
Visual acuity reduced 99.49 12.67 92 38509 21734 63428687
Food allergy 96.54 12.67 69 38532 11332 63439089
Eye pain 91.71 12.67 108 38493 33746 63416675
Oesophageal spasm 86.89 12.67 41 38560 3082 63447339
Sarcoidosis 86.63 12.67 54 38547 7068 63443353
Corneal epithelium defect 84.80 12.67 23 38578 329 63450092
Paradoxical drug reaction 81.46 12.67 43 38558 4109 63446312
Musculoskeletal injury 80.49 12.67 18 38583 107 63450314
Psoriasis 79.27 12.67 168 38433 86789 63363632
Drug intolerance 76.96 12.67 381 38220 308280 63142141
Pigment dispersion syndrome 76.87 12.67 12 38589 0 63450421
Temperature regulation disorder 75.86 12.67 47 38554 6085 63444336
Hepatic steatosis 74.99 12.67 90 38511 28679 63421742
Oesophageal pain 74.52 12.67 39 38562 3662 63446759
Nasal oedema 71.84 12.67 29 38572 1493 63448928
Lymphoedema 70.89 12.67 58 38543 11634 63438787
Nicotine dependence 68.66 12.67 23 38578 694 63449727
Rhinitis allergic 66.58 12.67 56 38545 11671 63438750
Sputum purulent 66.50 12.67 25 38576 1062 63449359
Ulcerative keratitis 64.58 12.67 32 38569 2678 63447743
Vitritis 61.36 12.67 23 38578 969 63449452
Acinetobacter infection 60.68 12.67 26 38575 1557 63448864
Immunodeficiency 60.55 12.67 68 38533 20186 63430235
Cough 59.04 12.67 341 38260 292402 63158019
Anaphylactic reaction 58.26 12.67 126 38475 65974 63384447
Mental disorder 57.81 12.67 75 38526 25844 63424577
Drug reaction with eosinophilia and systemic symptoms 56.22 12.67 85 38516 33751 63416670
Rash erythematous 55.88 12.67 96 38505 42414 63408007
Drug-induced liver injury 55.74 12.67 93 38508 40129 63410292
Cardiac murmur 54.37 12.67 55 38546 14497 63435924
Anterior chamber cell 54.28 12.67 18 38583 526 63449895
Secondary immunodeficiency 53.95 12.67 23 38578 1360 63449061
Bronchiectasis 53.12 12.67 57 38544 16085 63434336
Tinnitus 51.56 12.67 84 38517 35544 63414877
Iris hypopigmentation 50.48 12.67 9 38592 11 63450410
Ocular hyperaemia 50.31 12.67 69 38532 25075 63425346
Tuberculoma of central nervous system 49.18 12.67 15 38586 332 63450089
Alopecia 48.19 12.67 82 38519 337454 63112967
Jaundice cholestatic 47.94 12.67 38 38563 7286 63443135
Iris atrophy 47.77 12.67 11 38590 76 63450345
Pneumonia 47.76 12.67 455 38146 456312 62994109
Systemic lupus erythematosus 47.02 12.67 35 38566 208883 63241538
Herpes zoster 46.98 12.67 133 38468 82329 63368092
Product dose omission issue 46.89 12.67 44 38557 234269 63216152
Thrombocytopenia 46.79 12.67 199 38402 150958 63299463
Hepatotoxicity 46.53 12.67 82 38519 36959 63413462
Skin reaction 46.36 12.67 51 38550 14798 63435623
Corneal perforation 46.28 12.67 16 38585 532 63449889
Conjunctival hyperaemia 44.87 12.67 24 38577 2355 63448066
Vision blurred 44.54 12.67 140 38461 91784 63358637
Punctate keratitis 44.33 12.67 16 38585 605 63449816
Dysphoria 44.23 12.67 31 38570 4935 63445486
Coeliac disease 43.54 12.67 46 38555 12751 63437670
Anterior chamber disorder 43.46 12.67 11 38590 118 63450303
Off label use 43.25 12.67 611 37990 673851 62776570
Hypomania 41.77 12.67 33 38568 6297 63444124
Cataract 41.69 12.67 101 38500 56952 63393469
Treatment failure 41.48 12.67 234 38367 198809 63251612
Neuropathy peripheral 41.04 12.67 157 38444 113510 63336911
Photophobia 40.85 12.67 52 38549 17583 63432838
Pemphigus 39.78 12.67 32 38569 183694 63266727
Lung neoplasm malignant 39.47 12.67 54 38547 19579 63430842
Toxicity to various agents 39.15 12.67 56 38545 247194 63203227
Corneal disorder 39.06 12.67 20 38581 1794 63448627
Bronchitis chronic 38.36 12.67 27 38574 4326 63446095
Fluid retention 37.71 12.67 100 38501 59586 63390835
Forced expiratory volume decreased 37.38 12.67 28 38573 4940 63445481
Hyperhidrosis 37.34 12.67 147 38454 107689 63342732
Eye inflammation 36.54 12.67 29 38572 5570 63444851
Gastric disorder 36.13 12.67 74 38527 37295 63413126
Blood immunoglobulin A decreased 35.75 12.67 17 38584 1300 63449121
Hypertension 35.74 12.67 291 38310 279012 63171409
Glossodynia 35.30 12.67 34 38567 178842 63271579
Ototoxicity 35.20 12.67 17 38584 1345 63449076
Blood immunoglobulin M increased 34.88 12.67 16 38585 1127 63449294
Multiple fractures 34.83 12.67 34 38567 8584 63441837
Foetal death 34.77 12.67 38 38563 10942 63439479
Allergy to metals 34.67 12.67 14 38587 721 63449700
Maternal exposure during pregnancy 34.67 12.67 50 38551 220012 63230409
Intraocular pressure increased 34.45 12.67 29 38572 6049 63444372
Bursitis 34.23 12.67 72 38529 36969 63413452
Stenotrophomonas infection 34.21 12.67 19 38582 2008 63448413
Death 33.59 12.67 116 38485 374265 63076156
Rash 33.47 12.67 502 38099 560369 62890052
Toxic epidermal necrolysis 33.01 12.67 57 38544 25277 63425144
Factor V deficiency 32.68 12.67 8 38593 74 63450347
Dysbiosis 31.85 12.67 14 38587 892 63449529
Skin injury 31.20 12.67 17 38584 1731 63448690
Retinal haemorrhage 30.86 12.67 25 38576 4944 63445477
Tendonitis 30.78 12.67 48 38553 19567 63430854
Schizophrenia 30.75 12.67 34 38567 9918 63440503
Corneal deposits 30.29 12.67 10 38591 288 63450133
Tendon pain 30.17 12.67 21 38580 3305 63447116
Choroiditis 29.95 12.67 9 38592 189 63450232
Sputum discoloured 29.94 12.67 43 38558 16304 63434117
Hand deformity 29.53 12.67 32 38569 159425 63290996
Vitreous opacities 29.38 12.67 10 38591 317 63450104
Vomiting 29.26 12.67 490 38111 559127 62891294
Pathogen resistance 29.21 12.67 27 38574 6371 63444050
Chronic obstructive pulmonary disease 29.01 12.67 94 38507 62592 63387829
Vanishing bile duct syndrome 27.98 12.67 12 38589 720 63449701
Gastroenteritis staphylococcal 27.83 12.67 7 38594 73 63450348
Psychotic disorder 27.36 12.67 53 38548 25659 63424762
Keratitis 27.35 12.67 20 38581 3402 63447019
Hypotension 26.84 12.67 81 38520 272523 63177898
Infective keratitis 26.64 12.67 6 38595 37 63450384
Gait disturbance 26.57 12.67 44 38557 183134 63267287
Persistent corneal epithelial defect 26.54 12.67 5 38596 10 63450411
Product monitoring error 26.53 12.67 22 38579 4494 63445927
Non-infectious endophthalmitis 26.31 12.67 8 38593 175 63450246
Sleep apnoea syndrome 26.19 12.67 56 38545 29077 63421344
Injection site erythema 26.06 12.67 9 38592 83165 63367256
Blood immunoglobulin G increased 26.03 12.67 17 38584 2410 63448011
Respiratory tract infection 25.69 12.67 69 38532 41414 63409007
Corneal flap complication 25.62 12.67 4 38597 0 63450421
Respiratory moniliasis 25.54 12.67 8 38593 194 63450227
Anterior chamber inflammation 25.51 12.67 9 38592 318 63450103
Iridocyclitis 25.43 12.67 17 38584 2505 63447916
Myelosuppression 25.39 12.67 49 38552 23654 63426767
Urinary tract infection 25.10 12.67 80 38521 264604 63185817
Eye infection staphylococcal 24.85 12.67 7 38594 116 63450305
Foreign body sensation in eyes 24.82 12.67 16 38585 2218 63448203
Dehydration 24.81 12.67 42 38559 173312 63277109
Eye pruritus 24.31 12.67 42 38559 18629 63431792
Eye irritation 24.25 12.67 46 38555 21925 63428496
Swelling 24.22 12.67 86 38515 275292 63175129
Dyspnoea 24.04 12.67 548 38053 660765 62789656
Haemostasis 23.86 12.67 8 38593 242 63450179
Fibrin 23.39 12.67 4 38597 3 63450418
Nosocomial infection 23.36 12.67 14 38587 1707 63448714
Eosinophilic pneumonia acute 23.19 12.67 9 38592 417 63450004
Optic neuritis 22.98 12.67 27 38574 8408 63442013
Wound 22.95 12.67 40 38561 163223 63287198
Glaucoma 22.65 12.67 41 38560 18864 63431557
Morganella infection 22.40 12.67 10 38591 661 63449760
Corneal erosion 22.35 12.67 8 38593 295 63450126
Arthropathy 22.23 12.67 71 38530 234721 63215700
Embolism venous 22.02 12.67 17 38584 3137 63447284
Fall 21.98 12.67 144 38457 392190 63058231
Full blood count abnormal 21.94 12.67 55 38546 31662 63418759
Injection site pain 21.94 12.67 28 38573 129772 63320649
Anti-cyclic citrullinated peptide antibody positive 21.87 12.67 23 38578 116189 63334232
Deafness 21.58 12.67 39 38562 17918 63432503
Increased viscosity of bronchial secretion 21.39 12.67 8 38593 335 63450086
Corneal abscess 21.18 12.67 5 38596 39 63450382
Bradycardia 21.15 12.67 9 38592 73218 63377203
Retinal ischaemia 21.10 12.67 8 38593 348 63450073
Ventricular tachycardia 21.03 12.67 41 38560 19938 63430483
Keratitis bacterial 20.85 12.67 5 38596 42 63450379
Malignant neoplasm progression 20.84 12.67 12 38589 82109 63368312
Hallucination 20.83 12.67 77 38524 54740 63395681
Iodine allergy 20.67 12.67 10 38591 794 63449627
Atypical mycobacterial infection 20.47 12.67 11 38590 1089 63449332
Rheumatic disorder 20.24 12.67 16 38585 3056 63447365
Coma 20.10 12.67 7 38594 64357 63386064
Paraneoplastic syndrome 19.89 12.67 9 38592 614 63449807
Mediastinal effusion 19.48 12.67 5 38596 57 63450364
Prescribed overdose 19.35 12.67 55 38546 34098 63416323
Discomfort 19.28 12.67 46 38555 167328 63283093
Peripheral nerve injury 19.26 12.67 8 38593 443 63449978
Bronchitis 19.22 12.67 136 38465 124799 63325622
Bronchial ulceration 19.22 12.67 3 38598 0 63450421
Gonioscopy abnormal 19.22 12.67 3 38598 0 63450421
Nervous system disorder 19.14 12.67 38 38563 18728 63431693
Stevens-Johnson syndrome 19.11 12.67 45 38556 24905 63425516
Cataract operation 19.05 12.67 20 38581 5502 63444919
Cystitis 19.05 12.67 75 38526 54916 63395505
Vaccination site haemorrhage 19.00 12.67 4 38597 17 63450404
Blister 18.99 12.67 31 38570 129783 63320638
Corneal transplant 18.88 12.67 7 38594 286 63450135
Retinal vasculitis 18.86 12.67 10 38591 964 63449457
Trichophytosis 18.80 12.67 5 38596 66 63450355
Sinus pain 18.77 12.67 16 38585 3394 63447027
Skin odour abnormal 18.68 12.67 12 38589 1654 63448767
Hyperkalaemia 18.54 12.67 5 38596 54198 63396223
Suicide attempt 18.39 12.67 7 38594 60911 63389510
Caffeine allergy 18.31 12.67 4 38597 21 63450400
Forced vital capacity abnormal 18 12.67 4 38597 23 63450398
Red blood cell count increased 17.95 12.67 15 38586 3097 63447324
Helicobacter infection 17.87 12.67 18 38583 92767 63357654
Vitreous floaters 17.78 12.67 20 38581 5946 63444475
Obstructive airways disorder 17.71 12.67 39 38562 20660 63429761
Cerebrovascular accident 17.54 12.67 24 38577 108000 63342421
Malaise 17.41 12.67 352 38249 415602 63034819
Cryptococcosis 17.25 12.67 10 38591 1147 63449274
Rales 17.11 12.67 29 38572 12668 63437753
Productive cough 17.11 12.67 80 38521 63128 63387293
Therapeutic response decreased 17.08 12.67 8 38593 61517 63388904
Blindness unilateral 17.04 12.67 20 38581 6221 63444200
Injection site swelling 17.02 12.67 4 38597 47568 63402853
Upper respiratory tract irritation 16.98 12.67 6 38595 213 63450208
Implant site hypersensitivity 16.97 12.67 4 38597 31 63450390
Pericarditis 16.93 12.67 34 38567 131545 63318876
Macular cyst 16.86 12.67 4 38597 32 63450389
Detachment of retinal pigment epithelium 16.83 12.67 7 38594 389 63450032
Pupillary disorder 16.80 12.67 6 38595 220 63450201
Type IV hypersensitivity reaction 16.78 12.67 14 38587 2884 63447537
Hyperalbuminaemia 16.75 12.67 4 38597 33 63450388
Duodenal ulcer perforation 16.70 12.67 17 38584 87192 63363229
Type I hypersensitivity 16.60 12.67 14 38587 2928 63447493
Optic neuropathy 16.52 12.67 12 38589 2020 63448401
Biopsy colon abnormal 16.46 12.67 5 38596 109 63450312
Gastrooesophageal reflux disease 16.43 12.67 107 38494 95532 63354889
Enterococcal infection 16.40 12.67 22 38579 7826 63442595
Corneal neovascularisation 16.33 12.67 5 38596 112 63450309
Electrolyte imbalance 16.25 12.67 37 38564 20039 63430382
Fatigue 16.19 12.67 414 38187 887614 62562807
Hypertransaminasaemia 16.12 12.67 20 38581 6589 63443832
Delirium 15.97 12.67 67 38534 50474 63399947
Medication error 15.79 12.67 6 38595 52278 63398143
Injection site reaction 15.65 12.67 8 38593 58516 63391905
Multiple sclerosis relapse 15.61 12.67 5 38596 48473 63401948
Allergic cough 15.54 12.67 8 38593 726 63449695
Breast conserving surgery 15.46 12.67 9 38592 1040 63449381
Urticaria 15.23 12.67 161 38440 165641 63284780
Rhabdomyolysis 15.13 12.67 4 38597 43947 63406474
Nerve block 15.06 12.67 8 38593 774 63449647
Anterior chamber fibrin 14.96 12.67 4 38597 54 63450367
Multiple use of single-use product 14.91 12.67 10 38591 1482 63448939
Product used for unknown indication 14.85 12.67 7 38594 525 63449896
Bronchopulmonary aspergillosis 14.78 12.67 22 38579 8613 63441808
Sepsis 14.70 12.67 46 38555 153077 63297344
Keratitis fungal 14.59 12.67 5 38596 162 63450259
Aspergillus infection 14.40 12.67 21 38580 8072 63442349
Pruritus allergic 14.38 12.67 10 38591 1572 63448849
Hypoventilation 14.27 12.67 16 38585 4738 63445683
Eye discharge 14.23 12.67 18 38583 6045 63444376
Muscle spasms 14.23 12.67 48 38553 156102 63294319
Polyneuropathy 14.23 12.67 29 38572 14560 63435861
Retinal artery occlusion 13.98 12.67 10 38591 1643 63448778
Obstruction 13.90 12.67 13 38588 3114 63447307
Keratopathy 13.87 12.67 7 38594 609 63449812
Chest discomfort 13.72 12.67 114 38487 109855 63340566
Oedema 13.71 12.67 104 38497 97518 63352903
Acute kidney injury 13.58 12.67 99 38502 263316 63187105
Gastrointestinal mucosa hyperaemia 13.56 12.67 5 38596 201 63450220
Corneal defect 13.54 12.67 3 38598 17 63450404
Limb mass 13.53 12.67 13 38588 3219 63447202
Musculoskeletal stiffness 13.48 12.67 62 38539 184556 63265865
Atrial fibrillation 13.47 12.67 32 38569 116604 63333817
Circumstance or information capable of leading to medication error 13.32 12.67 14 38587 3856 63446565
Back pain 13.27 12.67 100 38501 264045 63186376
Pneumonia haemophilus 13.27 12.67 7 38594 668 63449753
Rash morbilliform 13.22 12.67 13 38588 3312 63447109
Thrombosis 13.12 12.67 12 38589 64743 63385678
Contusion 13.08 12.67 47 38554 149997 63300424
Pulmonary function test abnormal 13.07 12.67 10 38591 1820 63448601
Somnolence 13.05 12.67 60 38541 178625 63271796
Rubber sensitivity 12.96 12.67 11 38590 2320 63448101
Vitreous degeneration 12.87 12.67 3 38598 22 63450399
Pyelonephritis chronic 12.70 12.67 5 38596 241 63450180
Corneal infection 12.69 12.67 4 38597 99 63450322

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Visual acuity reduced 248.00 13.32 143 21475 16006 34919307
Choroiditis 225.76 13.32 65 21553 1150 34934163
Eye pain 206.13 13.32 119 21499 13343 34921970
Toxic anterior segment syndrome 201.52 13.32 59 21559 1110 34934203
Intraocular pressure increased 193.88 13.32 85 21533 5298 34930015
Electrocardiogram QT prolonged 177.58 13.32 169 21449 40783 34894530
Iris transillumination defect 176.06 13.32 28 21590 3 34935310
Corneal oedema 167.85 13.32 53 21565 1298 34934015
Endophthalmitis 165.09 13.32 67 21551 3441 34931872
Delirium 152.88 13.32 161 21457 43830 34891483
Uveitis 146.57 13.32 78 21540 7457 34927856
Drug resistance 145.96 13.32 124 21494 25803 34909510
Mycotic allergy 119.56 13.32 34 21584 574 34934739
Spirometry abnormal 118.04 13.32 35 21583 689 34934624
Mite allergy 114.73 13.32 34 21584 668 34934645
Sleep disorder due to a general medical condition 107.08 13.32 56 21562 5165 34930148
Dust allergy 106.18 13.32 34 21584 872 34934441
Conjunctivitis allergic 105.41 13.32 36 21582 1134 34934179
Off label use 103.30 13.32 521 21097 419003 34516310
Mental disorder 102.93 13.32 81 21537 15128 34920185
Anterior chamber cell 101.69 13.32 27 21591 348 34934965
Hypopyon 100.24 13.32 27 21591 369 34934944
Ulcerative keratitis 98.79 13.32 38 21580 1691 34933622
Dysphoria 94.89 13.32 40 21578 2262 34933051
Hepatotoxicity 75.22 13.32 79 21539 21406 34913907
Paradoxical drug reaction 71.74 13.32 37 21581 3314 34931999
Neuropathy peripheral 70.90 13.32 158 21460 83105 34852208
Corneal infiltrates 70.49 13.32 17 21601 144 34935169
Retinal haemorrhage 70.01 13.32 42 21576 5047 34930266
Corneal decompensation 68.36 13.32 12 21606 12 34935301
Musculoskeletal injury 67.49 13.32 16 21602 125 34935188
Iridocyclitis 65.74 13.32 28 21590 1624 34933689
Ototoxicity 64.92 13.32 29 21589 1888 34933425
Vitritis 63.39 13.32 23 21595 868 34934445
Asthma 61.11 13.32 101 21517 42555 34892758
Iris hypopigmentation 59.81 13.32 12 21606 37 34935276
Vitreous opacities 56.61 13.32 17 21601 350 34934963
Painful respiration 52.69 13.32 22 21596 1214 34934099
Pathogen resistance 52.60 13.32 45 21573 9437 34925876
Corneal perforation 52.06 13.32 14 21604 190 34935123
Product use in unapproved indication 51.72 13.32 175 21443 117324 34817989
Necrotising scleritis 48.23 13.32 11 21607 71 34935242
Conjunctival hyperaemia 47.08 13.32 25 21593 2377 34932936
Visual impairment 46.28 13.32 81 21537 35721 34899592
Normochromic normocytic anaemia 45.45 13.32 30 21588 4257 34931056
Death 44.81 13.32 114 21504 397935 34537378
Multiple-drug resistance 44.55 13.32 32 21586 5207 34930106
Chest injury 44.27 13.32 21 21597 1570 34933743
Immune reconstitution inflammatory syndrome 43.43 13.32 39 21579 8720 34926593
Walking aid user 43.38 13.32 22 21596 1902 34933411
Drug reaction with eosinophilia and systemic symptoms 41.78 13.32 74 21544 32938 34902375
Keratitis fungal 41.63 13.32 11 21607 139 34935174
Iris atrophy 41.43 13.32 10 21608 85 34935228
Nodule 41.20 13.32 34 21584 6785 34928528
Condition aggravated 40.32 13.32 229 21389 191967 34743346
Wheezing 40.30 13.32 83 21535 41319 34893994
Corneal epithelium defect 39.44 13.32 13 21605 366 34934947
Disorganised speech 38.21 13.32 16 21602 889 34934424
Corneal opacity 37.52 13.32 14 21604 572 34934741
Tendon discomfort 35.40 13.32 11 21607 255 34935058
Eye inflammation 34.97 13.32 20 21598 2198 34933115
Cystoid macular oedema 34.82 13.32 14 21604 701 34934612
Tendonitis 34.49 13.32 35 21583 9105 34926208
Hypoacusis 33.94 13.32 46 21572 16255 34919058
NPM1 gene mutation 33.82 13.32 9 21609 117 34935196
Drug ineffective for unapproved indication 33.74 13.32 56 21562 23659 34911654
Thalamic infarction 33.62 13.32 14 21604 767 34934546
Vision blurred 33.37 13.32 82 21536 45881 34889432
Ocular hyperaemia 32.95 13.32 38 21580 11414 34923899
Tachyarrhythmia 32.90 13.32 23 21595 3585 34931728
Retinal detachment 32.82 13.32 27 21591 5364 34929949
Tuberculosis 32.65 13.32 33 21585 8544 34926769
Persistent corneal epithelial defect 32.54 13.32 7 21611 33 34935280
Productive cough 32.41 13.32 72 21546 37741 34897572
Cataract 32.23 13.32 58 21560 26128 34909185
Product dose omission issue 32.10 13.32 17 21601 119694 34815619
Keratic precipitates 31.69 13.32 9 21609 151 34935162
Corneal scar 31.64 13.32 9 21609 152 34935161
Diastasis recti abdominis 31.57 13.32 7 21611 39 34935274
Skin injury 31.34 13.32 19 21599 2326 34932987
Tuberculoma of central nervous system 31.32 13.32 10 21608 254 34935059
Oral candidiasis 31.23 13.32 38 21580 12072 34923241
Vitreous haemorrhage 31.13 13.32 19 21599 2354 34932959
Anterior chamber inflammation 30.33 13.32 10 21608 282 34935031
Urethritis mycoplasmal 30.03 13.32 6 21612 18 34935295
Corynebacterium infection 29.62 13.32 12 21606 613 34934700
Bronchiolitis obliterans syndrome 29.45 13.32 9 21609 197 34935116
Tendon pain 29.45 13.32 20 21598 2975 34932338
Tuberculosis of central nervous system 29.41 13.32 9 21609 198 34935115
Flat anterior chamber of eye 29.38 13.32 7 21611 56 34935257
Drug-induced liver injury 28.28 13.32 58 21560 28774 34906539
Infective keratitis 28.01 13.32 5 21613 6 34935307
Chimerism 27.99 13.32 9 21609 234 34935079
Keratitis bacterial 27.55 13.32 7 21611 75 34935238
Overdose 27.40 13.32 11 21607 91048 34844265
Loss of personal independence in daily activities 27.12 13.32 62 21556 33117 34902196
Acoustic neuroma 26.86 13.32 8 21610 160 34935153
Eye abscess 26.86 13.32 8 21610 160 34935153
Pigment dispersion syndrome 26.46 13.32 5 21613 10 34935303
Full blood count abnormal 26.44 13.32 44 21574 18624 34916689
Dehydration 26.25 13.32 25 21593 129944 34805369
Acute myeloid leukaemia recurrent 25.00 13.32 16 21602 2154 34933159
Detachment of retinal pigment epithelium 24.70 13.32 10 21608 510 34934803
Scleromalacia 24.11 13.32 5 21613 19 34935294
Aortic aneurysm 23.84 13.32 25 21593 6754 34928559
Mycobacterium chelonae infection 23.42 13.32 11 21607 804 34934509
Fibrin 23.32 13.32 4 21614 3 34935310
Deafness neurosensory 23.19 13.32 17 21601 2854 34932459
Choroidal detachment 23.13 13.32 9 21609 413 34934900
Tinnitus 22.79 13.32 43 21575 20075 34915238
Toxicity to various agents 22.75 13.32 57 21561 200305 34735008
Conjunctival oedema 21.93 13.32 9 21609 475 34934838
Deafness unilateral 21.30 13.32 14 21604 1973 34933340
Sitting disability 21.24 13.32 7 21611 197 34935116
Corneal striae 21.17 13.32 4 21614 8 34935305
Vitreous haze 20.56 13.32 5 21613 44 34935269
Eye infection fungal 20.46 13.32 8 21610 372 34934941
Foreign body sensation in eyes 19.60 13.32 9 21609 625 34934688
Pulmonary venous thrombosis 19.48 13.32 6 21612 135 34935178
Blepharitis allergic 19.17 13.32 3 21615 0 34935313
Fall 19.16 13.32 63 21555 202822 34732491
Immune reconstitution inflammatory syndrome associated tuberculosis 19.01 13.32 8 21610 450 34934863
Nervous system disorder 18.91 13.32 33 21585 14510 34920803
Corneal transplant 18.79 13.32 5 21613 65 34935248
Intentional product use issue 18.74 13.32 80 21538 59736 34875577
Cerebrovascular accident 18.70 13.32 15 21603 84796 34850517
Arteriosclerosis coronary artery 18.45 13.32 30 21588 12455 34922858
Product delivery mechanism issue 18.44 13.32 6 21612 162 34935151
Chondritis 18.37 13.32 6 21612 164 34935149
Photophobia 18.19 13.32 22 21596 6942 34928371
Herpes zoster meningoencephalitis 18.10 13.32 7 21611 316 34934997
Trichoglossia 17.99 13.32 7 21611 321 34934992
Metamorphopsia 17.90 13.32 8 21610 521 34934792
Optic neuritis 17.89 13.32 16 21602 3558 34931755
Vitreous floaters 17.84 13.32 16 21602 3569 34931744
Axonal neuropathy 17.76 13.32 10 21608 1067 34934246
Feeling cold 17.71 13.32 27 21591 10612 34924701
Haematospermia 17.69 13.32 7 21611 336 34934977
Torsade de pointes 17.58 13.32 22 21596 7187 34928126
Cardiovascular disorder 17.42 13.32 26 21592 10030 34925283
Blood immunoglobulin G decreased 17.32 13.32 11 21607 1462 34933851
Masticatory pain 17.02 13.32 4 21614 30 34935283
Punctate keratitis 16.94 13.32 7 21611 376 34934937
Hypertension 16.93 13.32 37 21581 136406 34798907
FEV1/FVC ratio abnormal 16.79 13.32 4 21614 32 34935281
Corneal deposits 16.75 13.32 6 21612 218 34935095
Ocular icterus 16.75 13.32 14 21604 2843 34932470
Deafness 16.55 13.32 27 21591 11238 34924075
Cataract subcapsular 16.55 13.32 7 21611 399 34934914
Mechanical urticaria 16.42 13.32 5 21613 108 34935205
Retinal oedema 16.35 13.32 8 21610 640 34934673
Corneal disorder 16.29 13.32 9 21609 925 34934388
Retinal vasculitis 16.22 13.32 7 21611 419 34934894
Hydrocephalus 16.13 13.32 18 21600 5214 34930099
Idiopathic orbital inflammation 16.08 13.32 4 21614 39 34935274
Benign soft tissue neoplasm 16.05 13.32 5 21613 117 34935196
Choroidal haematoma 15.88 13.32 3 21615 6 34935307
Antibiotic associated colitis 15.88 13.32 3 21615 6 34935307
Incorrect product administration duration 15.61 13.32 17 21601 4794 34930519
Drug hypersensitivity 15.56 13.32 94 21524 80435 34854878
Transaminases increased 15.53 13.32 44 21574 26779 34908534
Prostate cancer 15.23 13.32 3 21615 39646 34895667
Incision site pain 15.11 13.32 11 21607 1827 34933486
Neurilemmoma benign 15.01 13.32 3 21615 9 34935304
Phosphorus metabolism disorder 15.01 13.32 3 21615 9 34935304
Suicide attempt 14.94 13.32 3 21615 39113 34896200
Myocardial infarction 14.88 13.32 33 21585 121052 34814261
Scleral thinning 14.77 13.32 3 21615 10 34935303
Hallucination 14.71 13.32 67 21551 51431 34883882
Mycobacterial infection 14.68 13.32 12 21606 2362 34932951
Tendon disorder 14.64 13.32 13 21605 2862 34932451
Mycobacterium abscessus infection 14.59 13.32 7 21611 537 34934776
Pupillary disorder 14.58 13.32 6 21612 319 34934994
Eye oedema 14.47 13.32 8 21610 824 34934489
Emotional distress 14.46 13.32 30 21588 14996 34920317
Intracardiac mass 14.42 13.32 5 21613 165 34935148
Ocular hypertension 14.36 13.32 8 21610 836 34934477
Toxic optic neuropathy 14.31 13.32 8 21610 842 34934471
Eye discharge 14.25 13.32 11 21607 1995 34933318
Hypotension 14.07 13.32 80 21538 221569 34713744
Obesity 13.94 13.32 27 21591 12851 34922462
Hypoxia 13.79 13.32 69 21549 55026 34880287
Anterior chamber disorder 13.77 13.32 4 21614 73 34935240
Anterior chamber flare 13.57 13.32 4 21614 77 34935236
Acute kidney injury 13.56 13.32 122 21496 304866 34630447
Hypersomnia 13.41 13.32 26 21592 12381 34922932

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Iris transillumination defect 421.66 12.10 76 54654 83 79689575
Toxic anterior segment syndrome 413.15 12.10 128 54602 2636 79687022
Corneal oedema 323.95 12.10 105 54625 2515 79687143
Endophthalmitis 314.38 12.10 130 54600 6298 79683360
Drug hypersensitivity 311.23 12.10 654 54076 298262 79391396
Visual acuity reduced 288.02 12.10 204 54526 29265 79660393
Electrocardiogram QT prolonged 248.14 12.10 308 54422 90078 79599580
Drug resistance 237.23 12.10 211 54519 42002 79647656
Choroiditis 236.45 12.10 71 54659 1310 79688348
Contrast media allergy 228.46 12.10 80 54650 2442 79687216
Hypopyon 227.42 12.10 66 54664 1076 79688582
Eye pain 213.47 12.10 189 54541 37389 79652269
Intraocular pressure increased 199.34 12.10 106 54624 9099 79680559
Asthma 179.64 12.10 328 54402 134767 79554891
Ulcerative keratitis 161.63 12.10 69 54661 3620 79686038
Wheezing 157.29 12.10 285 54445 116379 79573279
Corneal infiltrates 154.09 12.10 37 54693 273 79689385
Dysphoria 148.20 12.10 70 54660 4664 79684994
Anterior chamber cell 142.04 12.10 44 54686 905 79688753
Corneal opacity 138.91 12.10 44 54686 976 79688682
Delirium 135.34 12.10 223 54507 84404 79605254
Mental disorder 132.90 12.10 134 54596 31168 79658490
Paradoxical drug reaction 131.40 12.10 74 54656 7111 79682547
Off label use 128.39 12.10 1060 53670 906155 78783503
Total lung capacity increased 127.89 12.10 51 54679 2247 79687411
Asthma-chronic obstructive pulmonary disease overlap syndrome 117.62 12.10 53 54677 3168 79686490
Hepatotoxicity 117.45 12.10 160 54570 51192 79638466
Spirometry abnormal 116.79 12.10 38 54692 921 79688737
Corneal epithelium defect 114.66 12.10 35 54695 684 79688974
Uveitis 110.51 12.10 92 54638 16738 79672920
Vitritis 107.49 12.10 42 54688 1752 79687906
Iris hypopigmentation 107.04 12.10 21 54709 48 79689610
Loss of employment 105.50 12.10 46 54684 2541 79687117
Obliterative bronchiolitis 101.67 12.10 47 54683 2981 79686677
Corneal perforation 100.14 12.10 32 54698 731 79688927
Dust allergy 95.72 12.10 37 54693 1499 79688159
Oesophageal spasm 92.78 12.10 46 54684 3410 79686248
Mite allergy 92.51 12.10 34 54696 1196 79688462
Neuropathy peripheral 90.68 12.10 257 54473 141048 79548610
Pigment dispersion syndrome 89.48 12.10 16 54714 16 79689642
Iris atrophy 89.18 12.10 21 54709 141 79689517
Conjunctivitis allergic 88.23 12.10 36 54694 1684 79687974
Drug reaction with eosinophilia and systemic symptoms 87.87 12.10 158 54572 64086 79625572
Conjunctival hyperaemia 87.67 12.10 48 54682 4365 79685293
Nasal polyps 86.44 12.10 57 54673 7270 79682388
Mycotic allergy 85.53 12.10 34 54696 1485 79688173
Ototoxicity 83.24 12.10 42 54688 3232 79686426
Death 81.98 12.10 166 54564 566348 79123310
Iridocyclitis 81.17 12.10 43 54687 3661 79685997
Pathogen resistance 75.24 12.10 69 54661 14273 79675385
Tinnitus 75.16 12.10 120 54610 44213 79645445
Drug-induced liver injury 73.63 12.10 149 54581 65968 79623690
Sleep disorder due to a general medical condition 73.56 12.10 68 54662 14209 79675449
Toxicity to various agents 73.23 12.10 110 54620 421430 79268228
Oesophageal pain 72.69 12.10 42 54688 4237 79685421
Drug intolerance 71.35 12.10 364 54366 263755 79425903
Vitreous opacities 71.21 12.10 24 54706 651 79689007
Sarcoidosis 70.73 12.10 53 54677 8282 79681376
Vision blurred 69.28 12.10 194 54536 105704 79583954
Ocular hyperaemia 67.71 12.10 90 54640 28116 79661542
Tuberculoma of central nervous system 66.41 12.10 22 54708 565 79689093
Product dose omission issue 65.25 12.10 45 54685 247492 79442166
Torsade de pointes 64.84 12.10 73 54657 19239 79670419
Rhinitis allergic 64.31 12.10 59 54671 12210 79677448
Upper respiratory tract infection 62.59 12.10 170 54560 90998 79598660
Nasal oedema 61.78 12.10 28 54702 1696 79687962
Anaphylactic reaction 61.38 12.10 160 54570 83583 79606075
Corneal decompensation 60.62 12.10 13 54717 53 79689605
Temperature regulation disorder 60.61 12.10 42 54688 5811 79683847
Food allergy 60.57 12.10 54 54676 10770 79678888
Musculoskeletal injury 60.35 12.10 16 54714 183 79689475
Tendon pain 59.53 12.10 41 54689 5617 79684041
Anterior chamber disorder 58.68 12.10 15 54715 147 79689511
Sputum purulent 58.33 12.10 25 54705 1324 79688334
Persistent corneal epithelial defect 55.75 12.10 12 54718 50 79689608
Punctate keratitis 55.28 12.10 22 54708 964 79688694
Tendonitis 54.09 12.10 74 54656 23756 79665902
Eye inflammation 52.69 12.10 40 54690 6373 79683285
Nicotine dependence 52.47 12.10 21 54709 934 79688724
Retinal haemorrhage 52.05 12.10 44 54686 8173 79681485
Multiple-drug resistance 51.39 12.10 45 54685 8763 79680895
Infective keratitis 50.33 12.10 11 54719 50 79689608
Treatment failure 50.29 12.10 241 54489 170245 79519413
Cataract 50.02 12.10 123 54607 61997 79627661
Immune reconstitution inflammatory syndrome 49.36 12.10 54 54676 13787 79675871
Acinetobacter infection 49.16 12.10 28 54702 2749 79686909
Dehydration 48.90 12.10 59 54671 248128 79441530
Lymphoedema 48.80 12.10 51 54679 12362 79677296
Immunodeficiency 48.51 12.10 67 54663 21701 79667957
Bronchitis chronic 48.39 12.10 33 54697 4449 79685209
Full blood count abnormal 47.19 12.10 93 54637 40381 79649277
Psoriasis 46.23 12.10 151 54579 89436 79600222
Corneal disorder 45.74 12.10 25 54705 2266 79687392
Hypotension 45.26 12.10 153 54577 440164 79249494
Optic neuritis 44.57 12.10 43 54687 9477 79680181
Keratitis fungal 44.22 12.10 14 54716 310 79689348
Keratitis bacterial 44 12.10 12 54718 154 79689504
Cough 42.94 12.10 412 54318 366377 79323281
Photophobia 42.50 12.10 61 54669 20467 79669191
Hallucination 41.99 12.10 142 54588 85603 79604055
Cardiac murmur 41.89 12.10 53 54677 15771 79673887
Dysbiosis 41.17 12.10 19 54711 1200 79688458
Fibrin 40.56 12.10 8 54722 19 79689639
Corneal flap complication 39.67 12.10 7 54723 6 79689652
Productive cough 39.55 12.10 142 54588 88189 79601469
Necrotising scleritis 39.34 12.10 12 54718 234 79689424
Visual impairment 38.63 12.10 145 54585 91986 79597672
Fall 38.45 12.10 188 54542 487441 79202217
Corneal deposits 38.32 12.10 14 54716 484 79689174
Skin reaction 38.14 12.10 51 54679 16017 79673641
Rash erythematous 36.95 12.10 105 54625 57664 79631994
Alopecia 36.71 12.10 64 54666 231291 79458367
Coeliac disease 36.56 12.10 42 54688 11309 79678349
NPM1 gene mutation 36.55 12.10 10 54720 130 79689528
Corynebacterium infection 36.48 12.10 18 54712 1320 79688338
Foreign body sensation in eyes 36.18 12.10 21 54709 2136 79687522
Chest injury 35.86 12.10 23 54707 2798 79686860
Bronchiectasis 35.77 12.10 59 54671 22327 79667331
Corneal transplant 35.28 12.10 12 54718 335 79689323
Multiple fractures 35.23 12.10 35 54695 7991 79681667
Tendon discomfort 35.14 12.10 13 54717 466 79689192
Cerebrovascular accident 34.94 12.10 33 54697 155259 79534399
Acute kidney injury 34.50 12.10 212 54518 519192 79170466
Hyponatraemia 34.26 12.10 43 54687 177805 79511853
Forced expiratory volume decreased 34.16 12.10 34 54696 7780 79681878
Diastasis recti abdominis 34.06 12.10 7 54723 22 79689636
Disorganised speech 33.90 12.10 20 54710 2097 79687561
Keratitis 33.41 12.10 26 54704 4296 79685362
Hypomania 33.31 12.10 33 54697 7511 79682147
Systemic lupus erythematosus 33.28 12.10 21 54709 121128 79568530
Suicide attempt 33.24 12.10 8 54722 82924 79606734
Bradycardia 32.67 12.10 27 54703 135530 79554128
Blood immunoglobulin A decreased 32.21 12.10 17 54713 1436 79688222
Hepatic steatosis 31.74 12.10 76 54654 37662 79651996
Drug ineffective for unapproved indication 31.67 12.10 92 54638 51146 79638512
Painful respiration 31.65 12.10 23 54707 3430 79686228
Foetal death 31.53 12.10 33 54697 8011 79681647
Hyperkalaemia 31.19 12.10 20 54710 114378 79575280
Retinal detachment 31.12 12.10 35 54695 9212 79680446
Secondary immunodeficiency 30.69 12.10 22 54708 3212 79686446
Flat anterior chamber of eye 30.66 12.10 9 54721 153 79689505
Retinal vasculitis 30.48 12.10 16 54714 1337 79688321
Factor V deficiency 30.46 12.10 8 54722 88 79689570
Bronchitis 30.43 12.10 173 54557 130471 79559187
Deafness 30.37 12.10 53 54677 20984 79668674
Blood immunoglobulin M increased 30.33 12.10 16 54714 1350 79688308
Lung neoplasm malignant 30.18 12.10 62 54668 27730 79661928
Product use in unapproved indication 30.15 12.10 283 54447 250076 79439582
Hand deformity 29.97 12.10 17 54713 103902 79585756
Urethritis mycoplasmal 29.40 12.10 6 54724 18 79689640
Pneumonia 29.38 12.10 625 54105 659621 79030037
Pupillary disorder 29.35 12.10 12 54718 564 79689094
Atypical mycobacterial infection 29.32 12.10 17 54713 1726 79687932
Chimerism 29.17 12.10 10 54720 286 79689372
Aortic aneurysm 28.47 12.10 32 54698 8414 79681244
Glossodynia 28.27 12.10 18 54712 103319 79586339
Non-infectious endophthalmitis 28.07 12.10 10 54720 321 79689337
Bronchiolitis obliterans syndrome 27.84 12.10 10 54720 329 79689329
Cystoid macular oedema 27.31 12.10 17 54713 1963 79687695
Keratic precipitates 27.17 12.10 10 54720 353 79689305
Sputum discoloured 26.61 12.10 51 54679 21692 79667966
Urinary tract infection 26.42 12.10 98 54632 274414 79415244
Polyneuropathy 26.37 12.10 54 54676 24097 79665561
Pemphigus 26.35 12.10 18 54712 99564 79590094
Maternal exposure during pregnancy 26.30 12.10 33 54697 136505 79553153
Herpes zoster 26.28 12.10 130 54600 92953 79596705
Retinal ischaemia 25.74 12.10 12 54718 776 79688882
Normochromic normocytic anaemia 25.58 12.10 29 54701 7698 79681960
Stenotrophomonas infection 25.55 12.10 21 54709 3752 79685906
Injection site pain 25.41 12.10 31 54699 129807 79559851
Thalamic infarction 25.37 12.10 14 54716 1293 79688365
Chronic obstructive pulmonary disease 25.34 12.10 121 54609 85298 79604360
Detachment of retinal pigment epithelium 25.34 12.10 12 54718 804 79688854
Fatigue 25.27 12.10 468 54262 929259 78760399
Injection site erythema 25.25 12.10 11 54719 78186 79611472
Rash 25.23 12.10 546 54184 577812 79111846
Bronchial ulceration 25.14 12.10 4 54726 0 79689658
Aqueous humour leakage 25.14 12.10 4 54726 0 79689658
Neoplasm progression 25.07 12.10 3 54727 51679 79637979
Corneal scar 24.97 12.10 9 54721 299 79689359
Optic neuropathy 24.87 12.10 20 54710 3464 79686194
Tachyarrhythmia 24.54 12.10 27 54703 6935 79682723
Eye abscess 24.06 12.10 9 54721 333 79689325
Glaucoma 23.75 12.10 46 54684 19715 79669943
Bursitis 23.75 12.10 66 54664 35778 79653880
Peripheral nerve injury 23.71 12.10 11 54719 703 79688955
Anti-cyclic citrullinated peptide antibody positive 23.41 12.10 14 54716 83129 79606529
Acute myeloid leukaemia recurrent 23.26 12.10 19 54711 3364 79686294
Iris adhesions 23.22 12.10 10 54720 536 79689122
Skin injury 23.15 12.10 19 54711 3387 79686271
Blepharitis allergic 22.90 12.10 4 54726 3 79689655
Metamorphopsia 22.79 12.10 13 54717 1280 79688378
Anterior chamber inflammation 22.74 12.10 10 54720 564 79689094
Jaundice cholestatic 22.59 12.10 33 54697 11251 79678407
Hypoacusis 22.48 12.10 58 54672 30092 79659566
Wound 22.46 12.10 28 54702 116151 79573507
Psychotic disorder 22.45 12.10 71 54659 41331 79648327
Hyperhidrosis 22.27 12.10 179 54551 151313 79538345
Obstructive airways disorder 21.91 12.10 59 54671 31400 79658258
Chest discomfort 21.89 12.10 166 54564 137878 79551780
Respiratory moniliasis 21.83 12.10 8 54722 279 79689379
Eye oedema 21.82 12.10 15 54715 2048 79687610
Nosocomial infection 21.81 12.10 17 54713 2815 79686843
Choroidal detachment 21.75 12.10 10 54720 626 79689032
Vitreous haemorrhage 21.72 12.10 19 54711 3694 79685964
Cataract operation 21.64 12.10 22 54708 5163 79684495
Conjunctival oedema 21.37 12.10 12 54718 1146 79688512
Eye infection staphylococcal 21.31 12.10 7 54723 175 79689483
Dyspepsia 21.21 12.10 26 54704 108661 79580997
Acoustic neuroma 21.21 12.10 8 54722 303 79689355
Cardio-respiratory arrest 21.13 12.10 26 54704 108484 79581174
Sepsis 21.12 12.10 104 54626 269324 79420334
Stevens-Johnson syndrome 21.09 12.10 67 54663 39099 79650559
Blood immunoglobulin G increased 21.00 12.10 17 54713 2972 79686686
Corneal thinning 20.91 12.10 7 54723 186 79689472
Tuberculosis of central nervous system 20.87 12.10 9 54721 484 79689174
Tendon rupture 20.79 12.10 33 54697 12093 79677565
Fluid retention 20.79 12.10 99 54631 69710 79619948
Arthropathy 20.68 12.10 58 54672 177053 79512605
Discomfort 20.60 12.10 34 54696 125583 79564075
Cystitis 20.47 12.10 81 54649 52651 79637007
Respiratory arrest 20.40 12.10 7 54723 57543 79632115
Vitreous haze 20.38 12.10 6 54724 103 79689555
Malignant neoplasm progression 20.33 12.10 39 54691 135951 79553707
Pericarditis 20.28 12.10 25 54705 104211 79585447
Eye infection fungal 20.26 12.10 9 54721 520 79689138
Herpes zoster meningoencephalitis 20.04 12.10 10 54720 751 79688907
Coronary artery disease 19.92 12.10 10 54720 65464 79624194
Anterior chamber pigmentation 19.86 12.10 4 54726 11 79689647
Multiple sclerosis relapse 19.63 12.10 4 54726 46529 79643129
Blindness unilateral 19.56 12.10 26 54704 8120 79681538
Pruritus allergic 19.27 12.10 12 54718 1387 79688271
Haemostasis 19.21 12.10 8 54722 394 79689264
Immune reconstitution inflammatory syndrome associated tuberculosis 19.16 12.10 10 54720 826 79688832
Haematemesis 19.15 12.10 6 54724 52258 79637400
Scleromalacia 18.96 12.10 5 54725 56 79689602
General physical health deterioration 18.94 12.10 111 54619 275127 79414531
Eye discharge 18.89 12.10 22 54708 6012 79683646
Gonioscopy abnormal 18.86 12.10 3 54727 0 79689658
Mediastinal effusion 18.72 12.10 5 54725 59 79689599
Haematospermia 18.61 12.10 7 54723 263 79689395
Vaccination site haemorrhage 18.52 12.10 4 54726 17 79689641
Sleep apnoea syndrome 18.37 12.10 61 54669 36417 79653241
Cellulitis 18.37 12.10 29 54701 109031 79580627
Trichoglossia 18.37 12.10 9 54721 650 79689008
Multiple use of single-use product 18.22 12.10 10 54720 914 79688744
Myelosuppression 18.21 12.10 65 54665 40231 79649427
Retinal perivascular sheathing 18.20 12.10 5 54725 66 79689592
Pulmonary venous thrombosis 18.19 12.10 6 54724 152 79689506
Rheumatic disorder 18.15 12.10 16 54714 3142 79686516
Hypoglycaemia 18.10 12.10 26 54704 101568 79588090
Corneal neovascularisation 17.97 12.10 6 54724 158 79689500
Anterior chamber flare 17.93 12.10 6 54724 159 79689499
Caffeine allergy 17.82 12.10 4 54726 21 79689637
Tuberculosis 17.81 12.10 35 54695 15163 79674495
Thrombocytopenia 17.75 12.10 268 54462 264991 79424667
Vitreal cells 17.74 12.10 5 54725 73 79689585
Gastroenteritis staphylococcal 17.71 12.10 7 54723 301 79689357
Memory impairment 17.63 12.10 31 54699 111703 79577955
Gastric disorder 17.45 12.10 61 54669 37372 79652286
Headache 17.43 12.10 330 54400 653442 79036216
Mycobacterium chelonae infection 17.32 12.10 14 54716 2442 79687216
Injection site reaction 17.23 12.10 8 54722 54777 79634881
Lactic acidosis 16.97 12.10 14 54716 70345 79619313
Vomiting 16.86 12.10 586 54144 665242 79024416
Rhabdomyolysis 16.83 12.10 28 54702 103103 79586555
Phosphorus metabolism disorder 16.78 12.10 3 54727 3 79689655
Implant site hypersensitivity 16.72 12.10 4 54726 29 79689629
Vanishing bile duct syndrome 16.65 12.10 12 54718 1766 79687892
Eyelid oedema 16.62 12.10 32 54698 13655 79676003
Nocardiosis 16.61 12.10 20 54710 5659 79683999
Vitreous degeneration 16.60 12.10 4 54726 30 79689628
Forced vital capacity abnormal 16.60 12.10 4 54726 30 79689628
Lacrimation increased 16.51 12.10 43 54687 22434 79667224
Increased viscosity of bronchial secretion 16.48 12.10 8 54722 566 79689092
Biopsy colon abnormal 16.46 12.10 5 54725 96 79689562
Morganella infection 16.37 12.10 10 54720 1117 79688541
Disseminated mycobacterium avium complex infection 16.33 12.10 6 54724 211 79689447
Corneal erosion 16.29 12.10 7 54723 373 79689285
Overdose 16.29 12.10 68 54662 184138 79505520
Injection site swelling 16.25 12.10 6 54724 47126 79642532
Schizophrenia 16.24 12.10 34 54696 15406 79674252
Masticatory pain 16.16 12.10 4 54726 34 79689624
FEV1/FVC ratio abnormal 16.06 12.10 4 54726 35 79689623
Product use issue 16.04 12.10 217 54513 209605 79480053
Contraindicated product administered 16.01 12.10 172 54558 157366 79532292
Sitting disability 16.00 12.10 7 54723 390 79689268
Muscle spasms 15.76 12.10 64 54666 174666 79514992
Vitreous floaters 15.67 12.10 22 54708 7234 79682424
Retinal artery occlusion 15.65 12.10 15 54715 3279 79686379
Eye irritation 15.64 12.10 40 54690 20641 79669017
Acute myocardial infarction 15.49 12.10 18 54712 77018 79612640
Nervous system disorder 15.44 12.10 47 54683 26809 79662849
Anaemia 15.38 12.10 214 54516 444801 79244857
Rash morbilliform 15.34 12.10 20 54710 6130 79683528
Hypotony of eye 15.32 12.10 6 54724 252 79689406
Idiopathic orbital inflammation 15.25 12.10 6 54724 255 79689403
Scleral thinning 15.23 12.10 4 54726 44 79689614
Upper respiratory tract irritation 15.20 12.10 6 54724 257 79689401
Hyperalbuminaemia 15.15 12.10 4 54726 45 79689613
Benign soft tissue neoplasm 15.15 12.10 5 54725 127 79689531
Axonal neuropathy 15.11 12.10 12 54718 2042 79687616
Cardiogenic shock 15.02 12.10 5 54725 41909 79647749
Deafness neurosensory 15.02 12.10 21 54709 6877 79682781
Dyspnoea 14.98 12.10 725 54005 856300 78833358
Allergic cough 14.95 12.10 8 54722 695 79688963
Aqueous fibrin 14.93 12.10 5 54725 133 79689525
Visual acuity reduced transiently 14.92 12.10 6 54724 270 79689388
Nerve block 14.84 12.10 8 54722 705 79688953
Choroidal neovascularisation 14.81 12.10 7 54723 467 79689191
Mycobacterium avium complex infection 14.78 12.10 17 54713 4583 79685075
Enterococcal infection 14.77 12.10 33 54697 15627 79674031
Eye pruritus 14.75 12.10 39 54691 20531 79669127
Macular fibrosis 14.74 12.10 8 54722 715 79688943
Erythema of eyelid 14.73 12.10 13 54717 2557 79687101
Transient ischaemic attack 14.65 12.10 9 54721 52686 79636972
Toxic epidermal necrolysis 14.59 12.10 65 54665 44516 79645142
Swelling 14.58 12.10 88 54642 216623 79473035
Weight increased 14.58 12.10 121 54609 277265 79412393
Anaphylactic shock 14.54 12.10 56 54674 35940 79653718
Incorrect product administration duration 14.47 12.10 28 54702 11994 79677664
Cutis laxa 14.45 12.10 5 54725 147 79689511
Paraneoplastic syndrome 14.45 12.10 9 54721 1041 79688617
Complications of transplant surgery 14.39 12.10 8 54722 749 79688909
Dysmetria 14.28 12.10 9 54721 1062 79688596
AIDS related complication 14.22 12.10 4 54726 58 79689600
Therapeutic response decreased 14.12 12.10 15 54715 66838 79622820
Rectal haemorrhage 14.11 12.10 19 54711 76281 79613377
Drug ineffective 14.10 12.10 890 53840 1080023 78609635
Language disorder 14.08 12.10 14 54716 3200 79686458
Eosinophilic pneumonia acute 14.08 12.10 9 54721 1089 79688569
Breast conserving surgery 14.08 12.10 8 54722 782 79688876
Chondritis 14.05 12.10 5 54725 160 79689498
Sinus pain 14.04 12.10 15 54715 3727 79685931
Neurilemmoma benign 14.04 12.10 3 54727 12 79689646
Musculoskeletal stiffness 14.03 12.10 67 54663 174941 79514717
Hypersensitivity 13.88 12.10 255 54475 261984 79427674
Orthostatic hypotension 13.76 12.10 11 54719 56153 79633505
Prostate cancer 13.75 12.10 3 54727 33265 79656393
Anterior chamber fibrin 13.74 12.10 5 54725 171 79689487
Back pain 13.69 12.10 138 54592 304042 79385616
Toxic optic neuropathy 13.67 12.10 9 54721 1144 79688514
Incision site pain 13.66 12.10 13 54717 2817 79686841
Ocular hypertension 13.65 12.10 10 54720 1510 79688148
Dysdiadochokinesis 13.60 12.10 6 54724 341 79689317
Product monitoring error 13.59 12.10 23 54707 8883 79680775
Injection site pruritus 13.57 12.10 6 54724 42277 79647381
COVID-19 13.45 12.10 59 54671 157615 79532043
Suspected counterfeit product 13.40 12.10 7 54723 579 79689079
Keratopathy 13.39 12.10 9 54721 1185 79688473
Allergic sinusitis 13.38 12.10 8 54722 859 79688799
Circumstance or information capable of leading to medication error 13.38 12.10 15 54715 3933 79685725
Lethargy 13.33 12.10 22 54708 81270 79608388
Helicobacter infection 13.26 12.10 17 54713 69687 79619971
Vestibular disorder 13.24 12.10 12 54718 2443 79687215
Mycobacterium abscessus infection 13.20 12.10 9 54721 1213 79688445
Hepatic enzyme increased 13.20 12.10 187 54543 182423 79507235
Urticaria 13.12 12.10 189 54541 185012 79504646
Rheumatoid factor positive 13.12 12.10 13 54717 59826 79629832
Contusion 13.10 12.10 55 54675 148721 79540937
Respiratory tract infection 13.04 12.10 67 54663 48622 79641036
Nodule 12.99 12.10 40 54690 22954 79666704
Type IV hypersensitivity reaction 12.97 12.10 15 54715 4066 79685592
Tendon disorder 12.93 12.10 20 54710 7166 79682492
Scleral disorder 12.81 12.10 5 54725 208 79689450
Limb mass 12.76 12.10 14 54716 3585 79686073
Corneal striae 12.76 12.10 3 54727 20 79689638
Duodenal ulcer perforation 12.75 12.10 16 54714 66195 79623463
Somnolence 12.67 12.10 104 54626 238877 79450781
Atypical mycobacterium test positive 12.63 12.10 3 54727 21 79689637
Skin odour abnormal 12.61 12.10 11 54719 2130 79687528
Red blood cell count increased 12.60 12.10 15 54715 4193 79685465
Retinal oedema 12.60 12.10 8 54722 957 79688701
Osteonecrosis of jaw 12.56 12.10 7 54723 43219 79646439
Legionella test positive 12.51 12.10 3 54727 22 79689636
Intracardiac mass 12.42 12.10 5 54725 226 79689432
Ocular icterus 12.36 12.10 17 54713 5483 79684175
Hip fracture 12.26 12.10 3 54727 30758 79658900

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC J01MA14 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
QUINOLONE ANTIBACTERIALS
Fluoroquinolones
ATC S01AE07 SENSORY ORGANS
OPHTHALMOLOGICALS
ANTIINFECTIVES
Fluoroquinolones
FDA CS M0023650 Quinolones
FDA CS M0372253 Fluoroquinolones
MeSH PA D000900 Anti-Bacterial Agents
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000970 Antineoplastic Agents
MeSH PA D004791 Enzyme Inhibitors
MeSH PA D059005 Topoisomerase II Inhibitors
MeSH PA D059003 Topoisomerase Inhibitors
CHEBI has role CHEBI:36047 antibacterial drugs
FDA EPC N0000175937 Quinolone Antimicrobial
FDA EPC N0000193223 Fluoroquinolone Antibacterial

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Septicemic plague indication 9012003 DOID:3481
Infection of skin AND/OR subcutaneous tissue indication 19824006
Staphylococcal pneumonia indication 22754005
Pneumonia due to Streptococcus indication 34020007
Pneumonic plague indication 38976008 DOID:10398
Pneumonia due to Mycoplasma pneumoniae indication 46970008
Peritonitis indication 48661000
Bacterial pneumonia indication 53084003 DOID:874
Pneumonia due to Klebsiella pneumoniae indication 64479007
Haemophilus influenzae pneumonia indication 70036007
Rhinoscleroma indication 72409005 DOID:11336
Abdominal abscess indication 75100008
Acute bacterial sinusitis indication 75498004
Infectious disease of abdomen indication 128070006
Bacterial conjunctivitis indication 128350005 DOID:9700
Infection due to Enterobacteriaceae indication 128945009
Bacterial infection due to Klebsiella pneumoniae indication 186435004
Pneumococcal pneumonia indication 233607000
Chlamydial pneumonia indication 233609002
Streptococcus pyogenes infection indication 302809008
Infection due to Staphylococcus aureus indication 406602003
Acute exacerbation of chronic bronchitis indication 425748003
Complicated Skin and Skin Structure E. Coli Infection indication
Complicated Skin and Skin Structure Infection indication
Haemophilus Influenzae Chronic Bronchitis indication
Complicated Skin and Skin Structure Staphylococcus Aureus Infection indication
Haemophilus Parainfluenzae Chronic Bronchitis indication
Streptococcus Pneumoniae Chronic Bronchitis indication
Moraxella Catarrhalis Pneumonia indication
Staphylococcus Chronic Bronchitis indication
Klebsiella Pneumoniae Chronic Bronchitis indication
Moraxella Catarrhalis Chronic Bronchitis indication
Acute tuberculosis off-label use 25629007
Pulmonary tuberculosis off-label use 154283005 DOID:2957
Cirrhosis of liver contraindication 19943007 DOID:5082
Torsades de pointes contraindication 31722008
Transplantation of heart contraindication 32413006
Tendinitis contraindication 34840004 DOID:971
Hypokalemia contraindication 43339004
Conduction disorder of the heart contraindication 44808001
Bradycardia contraindication 48867003
Transplant of kidney contraindication 70536003
Epilepsy contraindication 84757009 DOID:1826
Transplant of lung contraindication 88039007
Myasthenia gravis contraindication 91637004 DOID:437
Prolonged QT interval contraindication 111975006
Liver function tests abnormal contraindication 166603001
Drug-induced hepatitis contraindication 235876009
Peripheral nerve disease contraindication 302226006
Pseudomembranous enterocolitis contraindication 397683000
Myocardial ischemia contraindication 414795007 DOID:3393
Traumatic rupture of tendon contraindication 415749005
Congenital long QT syndrome contraindication 442917000
Severe Cerebral Arteriosclerosis contraindication




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 6.23 acidic
pKa2 8.54 Basic
pKa3 2.92 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Topoisomerase IV Enzyme INHIBITOR CHEMBL CHEMBL
DNA gyrase Enzyme INHIBITOR IC50 6.52 CHEMBL CHEMBL
DNA topoisomerase 4 subunit A Enzyme IC50 6.10 CHEMBL
DNA gyrase subunit A Enzyme IC50 5.04 CHEMBL

External reference:

IDSource
D00874 KEGG_DRUG
186826-86-8 SECONDARY_CAS_RN
4021185 VANDF
4021186 VANDF
C0536495 UMLSCUI
CHEBI:63611 CHEBI
MFX PDB_CHEM_ID
CHEMBL32 ChEMBL_ID
CHEMBL1200735 ChEMBL_ID
D000077266 MESH_DESCRIPTOR_UI
DB00218 DRUGBANK_ID
152946 PUBCHEM_CID
10915 IUPHAR_LIGAND_ID
7659 INN_ID
U188XYD42P UNII
1047505 RXNORM
178916 MMSL
213098 MMSL
31558 MMSL
35332 MMSL
359581 MMSL
359583 MMSL
40847 MMSL
8580 MMSL
d04500 MMSL
007927 NDDF
007928 NDDF
116347002 SNOMEDCT_US
371296007 SNOMEDCT_US
412439003 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
MOXEZA HUMAN PRESCRIPTION DRUG LABEL 1 0065-0006 SOLUTION 5 mg OPHTHALMIC NDA 23 sections
VIGAMOX HUMAN PRESCRIPTION DRUG LABEL 1 0065-4013 SOLUTION/ DROPS 5 mg OPHTHALMIC NDA 25 sections
VIGAMOX HUMAN PRESCRIPTION DRUG LABEL 1 0065-4013 SOLUTION/ DROPS 5 mg OPHTHALMIC NDA 25 sections
VIGAMOX HUMAN PRESCRIPTION DRUG LABEL 1 0078-0939 SOLUTION/ DROPS 5 mg OPHTHALMIC NDA 25 sections
VIGAMOX HUMAN PRESCRIPTION DRUG LABEL 1 0078-0939 SOLUTION/ DROPS 5 mg OPHTHALMIC NDA 25 sections
VIGAMOX HUMAN PRESCRIPTION DRUG LABEL 1 0078-0939 SOLUTION/ DROPS 5 mg OPHTHALMIC NDA 25 sections
Moxifloxacin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0093-7387 TABLET, FILM COATED 400 mg ORAL ANDA 28 sections
Moxifloxacin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0093-7387 TABLET, FILM COATED 400 mg ORAL ANDA 28 sections
Moxifloxacin HUMAN PRESCRIPTION DRUG LABEL 1 0378-5430 SOLUTION/ DROPS 5 mg OPHTHALMIC ANDA 24 sections
Moxifloxacin HUMAN PRESCRIPTION DRUG LABEL 1 0378-5430 SOLUTION/ DROPS 5 mg OPHTHALMIC ANDA 24 sections
Moxifloxacin Ophthalmic Solution HUMAN PRESCRIPTION DRUG LABEL 1 0781-7135 SOLUTION/ DROPS 5 mg OPHTHALMIC NDA authorized generic 25 sections
Moxifloxacin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0832-1410 SOLUTION 5 mg OPHTHALMIC ANDA 26 sections
Moxifloxacin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0832-1410 SOLUTION 5 mg OPHTHALMIC ANDA 26 sections
Moxifloxacin HUMAN PRESCRIPTION DRUG LABEL 1 0904-6406 TABLET, FILM COATED 400 mg ORAL ANDA 30 sections
Moxifloxacin HUMAN PRESCRIPTION DRUG LABEL 1 0904-6406 TABLET, FILM COATED 400 mg ORAL ANDA 30 sections
moxifloxacin hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 13668-201 TABLET 400 mg ORAL ANDA 29 sections
moxifloxacin hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 13668-201 TABLET 400 mg ORAL ANDA 29 sections
moxifloxacin hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 13668-201 TABLET 400 mg ORAL ANDA 29 sections
Avelox ABC Pack HUMAN PRESCRIPTION DRUG LABEL 1 16590-881 TABLET, FILM COATED 400 mg ORAL NDA 17 sections
MOXIFLOXACIN Human Prescription Drug Label 1 16714-643 SOLUTION/ DROPS 5 mg OPHTHALMIC ANDA 23 sections
MOXIFLOXACIN Human Prescription Drug Label 1 16714-643 SOLUTION/ DROPS 5 mg OPHTHALMIC ANDA 23 sections
Moxifloxacin HUMAN PRESCRIPTION DRUG LABEL 1 17478-519 SOLUTION/ DROPS 5 mg OPHTHALMIC ANDA 25 sections
VIGAMOX HUMAN PRESCRIPTION DRUG LABEL 1 21695-968 SOLUTION 5 mg OPHTHALMIC NDA 20 sections
Moxifloxacin HUMAN PRESCRIPTION DRUG LABEL 1 31722-845 TABLET, FILM COATED 400 mg ORAL ANDA 28 sections
Moxifloxacin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 40032-034 TABLET 400 mg ORAL ANDA 28 sections
Moxifloxacin HUMAN PRESCRIPTION DRUG LABEL 1 50090-3147 TABLET, FILM COATED 400 mg ORAL ANDA 30 sections
Moxifloxacin HUMAN PRESCRIPTION DRUG LABEL 1 50090-3147 TABLET, FILM COATED 400 mg ORAL ANDA 30 sections
Moxifloxacin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 50090-4058 TABLET 400 mg ORAL ANDA 32 sections
Moxifloxacin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 50090-4058 TABLET 400 mg ORAL ANDA 32 sections
Moxifloxacin Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 50090-4100 TABLET 400 mg ORAL ANDA 32 sections