Stem definition | Drug id | CAS RN |
---|---|---|
antibacterials, nalidixic acid derivatives | 1854 | 151096-09-2 |
Dose | Unit | Route |
---|---|---|
0.40 | g | O |
0.40 | g | P |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 3 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 27.50 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 22 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 14.23 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 86 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 1.40 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 2.40 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.60 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 8.20 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Dec. 10, 1999 | FDA | BAYER HLTHCARE |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Drug hypersensitivity | 315.38 | 13.37 | 508 | 25821 | 250502 | 50328293 |
Contrast media allergy | 306.96 | 13.37 | 89 | 26240 | 1938 | 50576857 |
Toxic anterior segment syndrome | 269.68 | 13.37 | 76 | 26253 | 1489 | 50577306 |
Iris transillumination defect | 264.65 | 13.37 | 45 | 26284 | 44 | 50578751 |
Corneal oedema | 171.20 | 13.37 | 52 | 26277 | 1335 | 50577460 |
Endophthalmitis | 169.63 | 13.37 | 62 | 26267 | 2854 | 50575941 |
Hypopyon | 150.15 | 13.37 | 40 | 26289 | 629 | 50578166 |
Electrocardiogram QT prolonged | 148.50 | 13.37 | 158 | 26171 | 51728 | 50527067 |
Torsade de pointes | 133.98 | 13.37 | 81 | 26248 | 11754 | 50567041 |
Obliterative bronchiolitis | 128.95 | 13.37 | 45 | 26284 | 1808 | 50576987 |
Drug resistance | 127.78 | 13.37 | 94 | 26235 | 18895 | 50559900 |
Corneal infiltrates | 106.38 | 13.37 | 22 | 26307 | 102 | 50578693 |
Visual acuity reduced | 105.62 | 13.37 | 86 | 26243 | 20053 | 50558742 |
Corneal epithelium defect | 89.48 | 13.37 | 23 | 26306 | 312 | 50578483 |
Upper respiratory tract infection | 88.66 | 13.37 | 138 | 26191 | 65760 | 50513035 |
Eye pain | 87.37 | 13.37 | 90 | 26239 | 28359 | 50550436 |
Corneal opacity | 87.09 | 13.37 | 26 | 26303 | 628 | 50578167 |
Musculoskeletal injury | 83.43 | 13.37 | 18 | 26311 | 106 | 50578689 |
Asthma-chronic obstructive pulmonary disease overlap syndrome | 81.52 | 13.37 | 23 | 26306 | 452 | 50578343 |
Pigment dispersion syndrome | 78.74 | 13.37 | 12 | 26317 | 0 | 50578795 |
Loss of employment | 71.52 | 13.37 | 28 | 26301 | 1558 | 50577237 |
Drug intolerance | 70.45 | 13.37 | 262 | 26067 | 218842 | 50359953 |
Drug reaction with eosinophilia and systemic symptoms | 66.57 | 13.37 | 78 | 26251 | 28346 | 50550449 |
Nicotine dependence | 65.89 | 13.37 | 21 | 26308 | 634 | 50578161 |
Psoriasis | 65.75 | 13.37 | 124 | 26205 | 68876 | 50509919 |
Sputum purulent | 65.52 | 13.37 | 23 | 26306 | 940 | 50577855 |
Ulcerative keratitis | 64.26 | 13.37 | 29 | 26300 | 2304 | 50576491 |
Total lung capacity increased | 63.74 | 13.37 | 21 | 26308 | 706 | 50578089 |
Vitritis | 63.61 | 13.37 | 22 | 26307 | 860 | 50577935 |
Neuropathy peripheral | 62.13 | 13.37 | 148 | 26181 | 96609 | 50482186 |
Ocular hyperaemia | 61.94 | 13.37 | 64 | 26265 | 20228 | 50558567 |
Mental disorder | 61.16 | 13.37 | 66 | 26263 | 21925 | 50556870 |
Asthma | 59.91 | 13.37 | 139 | 26190 | 89198 | 50489597 |
Anaphylactic reaction | 58.94 | 13.37 | 103 | 26226 | 53952 | 50524843 |
Paradoxical drug reaction | 57.51 | 13.37 | 31 | 26298 | 3616 | 50575179 |
Acinetobacter infection | 56.72 | 13.37 | 23 | 26306 | 1404 | 50577391 |
Oesophageal spasm | 55.29 | 13.37 | 26 | 26303 | 2270 | 50576525 |
Secondary immunodeficiency | 53.66 | 13.37 | 21 | 26308 | 1167 | 50577628 |
Nasal polyps | 52.66 | 13.37 | 26 | 26303 | 2528 | 50576267 |
Hepatic steatosis | 52.31 | 13.37 | 64 | 26265 | 24320 | 50554475 |
Systemic lupus erythematosus | 52.24 | 13.37 | 6 | 26323 | 140616 | 50438179 |
Tuberculoma of central nervous system | 52.09 | 13.37 | 15 | 26314 | 318 | 50578477 |
Pemphigus | 50.48 | 13.37 | 3 | 26326 | 120163 | 50458632 |
Anterior chamber cell | 50.36 | 13.37 | 16 | 26313 | 478 | 50578317 |
Arthropathy | 49.13 | 13.37 | 11 | 26318 | 157895 | 50420900 |
Vision blurred | 49.07 | 13.37 | 119 | 26210 | 78528 | 50500267 |
Punctate keratitis | 48.47 | 13.37 | 16 | 26313 | 541 | 50578254 |
Conjunctival hyperaemia | 48.37 | 13.37 | 23 | 26306 | 2059 | 50576736 |
Glossodynia | 48.20 | 13.37 | 3 | 26326 | 115566 | 50463229 |
Lymphoedema | 47.91 | 13.37 | 39 | 26290 | 9083 | 50569712 |
Herpes zoster | 47.29 | 13.37 | 110 | 26219 | 70676 | 50508119 |
Corneal perforation | 46.62 | 13.37 | 15 | 26314 | 467 | 50578328 |
Oesophageal pain | 44.69 | 13.37 | 24 | 26305 | 2778 | 50576017 |
Synovitis | 44.27 | 13.37 | 6 | 26323 | 123859 | 50454936 |
Corneal disorder | 44.11 | 13.37 | 20 | 26309 | 1606 | 50577189 |
Wheezing | 42.08 | 13.37 | 97 | 26232 | 61950 | 50516845 |
Photophobia | 41.95 | 13.37 | 45 | 26284 | 14842 | 50563953 |
Thrombocytopenia | 41.22 | 13.37 | 153 | 26176 | 127520 | 50451275 |
Eye pruritus | 40.92 | 13.37 | 41 | 26288 | 12493 | 50566302 |
Alopecia | 39.00 | 13.37 | 42 | 26287 | 245005 | 50333790 |
Anterior chamber disorder | 38.58 | 13.37 | 9 | 26320 | 79 | 50578716 |
Dysbiosis | 38.26 | 13.37 | 14 | 26315 | 646 | 50578149 |
Tinnitus | 37.92 | 13.37 | 59 | 26270 | 28073 | 50550722 |
Hand deformity | 37.91 | 13.37 | 4 | 26325 | 100195 | 50478600 |
Bronchitis chronic | 37.46 | 13.37 | 24 | 26305 | 3853 | 50574942 |
Stenotrophomonas infection | 37.44 | 13.37 | 18 | 26311 | 1651 | 50577144 |
Toxic epidermal necrolysis | 37.01 | 13.37 | 50 | 26279 | 20942 | 50557853 |
Off label use | 36.56 | 13.37 | 392 | 25937 | 474034 | 50104761 |
Intraocular pressure increased | 36.40 | 13.37 | 27 | 26302 | 5489 | 50573306 |
Iris atrophy | 36.40 | 13.37 | 8 | 26321 | 52 | 50578743 |
Retinal haemorrhage | 36.15 | 13.37 | 25 | 26304 | 4556 | 50574239 |
Tendonitis | 36.08 | 13.37 | 44 | 26285 | 16661 | 50562134 |
Skin injury | 35.38 | 13.37 | 17 | 26312 | 1557 | 50577238 |
Dysphoria | 35.22 | 13.37 | 25 | 26304 | 4749 | 50574046 |
Factor V deficiency | 33.92 | 13.37 | 8 | 26321 | 74 | 50578721 |
Forced expiratory volume decreased | 32.39 | 13.37 | 23 | 26306 | 4371 | 50574424 |
Product dose omission issue | 32.12 | 13.37 | 29 | 26300 | 183809 | 50394986 |
Cough | 32.02 | 13.37 | 225 | 26104 | 241039 | 50337756 |
Ventricular tachycardia | 31.49 | 13.37 | 40 | 26289 | 15781 | 50563014 |
Vanishing bile duct syndrome | 31.41 | 13.37 | 12 | 26317 | 625 | 50578170 |
Food allergy | 31.05 | 13.37 | 29 | 26300 | 8108 | 50570687 |
Skin reaction | 30.91 | 13.37 | 34 | 26295 | 11534 | 50567261 |
Foreign body sensation in eyes | 30.26 | 13.37 | 16 | 26313 | 1795 | 50577000 |
Tendon pain | 30.18 | 13.37 | 19 | 26310 | 2959 | 50575836 |
Cataract | 29.95 | 13.37 | 72 | 26257 | 47228 | 50531567 |
Non-infectious endophthalmitis | 29.39 | 13.37 | 8 | 26321 | 137 | 50578658 |
Maternal exposure during pregnancy | 29.38 | 13.37 | 24 | 26305 | 159754 | 50419041 |
Gastroenteritis staphylococcal | 29.18 | 13.37 | 7 | 26322 | 70 | 50578725 |
Eye irritation | 28.97 | 13.37 | 40 | 26289 | 17100 | 50561695 |
Full blood count abnormal | 28.70 | 13.37 | 47 | 26282 | 23341 | 50555454 |
Drug-induced liver injury | 28.63 | 13.37 | 52 | 26277 | 28043 | 50550752 |
Ototoxicity | 27.87 | 13.37 | 13 | 26316 | 1114 | 50577681 |
Anterior chamber inflammation | 27.86 | 13.37 | 9 | 26320 | 284 | 50578511 |
Embolism venous | 27.84 | 13.37 | 17 | 26312 | 2508 | 50576287 |
Eosinophilic pneumonia acute | 27.36 | 13.37 | 9 | 26320 | 301 | 50578494 |
Delirium | 27.32 | 13.37 | 61 | 26268 | 38131 | 50540664 |
Pathogen resistance | 27.13 | 13.37 | 23 | 26306 | 5666 | 50573129 |
Deafness | 27.09 | 13.37 | 37 | 26292 | 15654 | 50563141 |
Eye infection staphylococcal | 26.79 | 13.37 | 6 | 26323 | 43 | 50578752 |
Allergy to metals | 26.43 | 13.37 | 10 | 26319 | 507 | 50578288 |
Iris hypopigmentation | 26.25 | 13.37 | 4 | 26325 | 0 | 50578795 |
Corneal flap complication | 26.25 | 13.37 | 4 | 26325 | 0 | 50578795 |
Stevens-Johnson syndrome | 25.74 | 13.37 | 43 | 26286 | 21709 | 50557086 |
Sarcoidosis | 25.40 | 13.37 | 21 | 26308 | 4996 | 50573799 |
Sputum discoloured | 25.30 | 13.37 | 33 | 26296 | 13362 | 50565433 |
Corneal erosion | 25.24 | 13.37 | 8 | 26321 | 237 | 50578558 |
Morganella infection | 25.23 | 13.37 | 10 | 26319 | 575 | 50578220 |
Haemostasis | 25.18 | 13.37 | 8 | 26321 | 239 | 50578556 |
Vitreous opacities | 24.96 | 13.37 | 8 | 26321 | 246 | 50578549 |
Wound | 24.80 | 13.37 | 12 | 26317 | 105782 | 50473013 |
Increased viscosity of bronchial secretion | 24.75 | 13.37 | 8 | 26321 | 253 | 50578542 |
Eye inflammation | 24.25 | 13.37 | 19 | 26310 | 4189 | 50574606 |
Obstructive airways disorder | 24.19 | 13.37 | 35 | 26294 | 15617 | 50563178 |
Rash erythematous | 24.19 | 13.37 | 55 | 26274 | 34797 | 50543998 |
Nosocomial infection | 24.17 | 13.37 | 13 | 26316 | 1509 | 50577286 |
Fibrin | 24.01 | 13.37 | 4 | 26325 | 3 | 50578792 |
Fall | 23.62 | 13.37 | 92 | 26237 | 334840 | 50243955 |
Hepatotoxicity | 23.56 | 13.37 | 47 | 26282 | 27179 | 50551616 |
Iodine allergy | 23.48 | 13.37 | 10 | 26319 | 691 | 50578104 |
Nervous system disorder | 23.23 | 13.37 | 35 | 26294 | 16188 | 50562607 |
Retinal ischaemia | 23.02 | 13.37 | 8 | 26321 | 317 | 50578478 |
Infective keratitis | 22.69 | 13.37 | 5 | 26324 | 33 | 50578762 |
Paraneoplastic syndrome | 22.60 | 13.37 | 9 | 26320 | 524 | 50578271 |
Persistent corneal epithelial defect | 22.59 | 13.37 | 4 | 26325 | 6 | 50578789 |
Rhinitis allergic | 22.49 | 13.37 | 23 | 26306 | 7177 | 50571618 |
Dehydration | 22.21 | 13.37 | 28 | 26301 | 152421 | 50426374 |
Condition aggravated | 21.98 | 13.37 | 80 | 26249 | 296978 | 50281817 |
Corneal abscess | 21.96 | 13.37 | 5 | 26324 | 39 | 50578756 |
Injection site erythema | 21.78 | 13.37 | 6 | 26323 | 74930 | 50503865 |
Treatment failure | 21.65 | 13.37 | 134 | 26195 | 137503 | 50441292 |
Pericarditis | 21.60 | 13.37 | 7 | 26322 | 78682 | 50500113 |
Rash | 21.53 | 13.37 | 333 | 25996 | 437138 | 50141657 |
Peripheral nerve injury | 21.36 | 13.37 | 8 | 26321 | 394 | 50578401 |
Cryptococcosis | 21.21 | 13.37 | 10 | 26319 | 878 | 50577917 |
Toxicity to various agents | 20.95 | 13.37 | 50 | 26279 | 212449 | 50366346 |
Trichophytosis | 20.58 | 13.37 | 5 | 26324 | 53 | 50578742 |
Mediastinal effusion | 20.58 | 13.37 | 5 | 26324 | 53 | 50578742 |
Vitreous floaters | 20.39 | 13.37 | 19 | 26310 | 5295 | 50573500 |
Optic neuropathy | 20.22 | 13.37 | 12 | 26317 | 1682 | 50577113 |
Gastric disorder | 19.81 | 13.37 | 46 | 26283 | 29502 | 50549293 |
Gonioscopy abnormal | 19.69 | 13.37 | 3 | 26326 | 0 | 50578795 |
Bronchial ulceration | 19.69 | 13.37 | 3 | 26326 | 0 | 50578795 |
Sinus pain | 19.41 | 13.37 | 13 | 26316 | 2248 | 50576547 |
Gait disturbance | 19.41 | 13.37 | 30 | 26299 | 149975 | 50428820 |
Forced vital capacity abnormal | 19.09 | 13.37 | 4 | 26325 | 20 | 50578775 |
Skin odour abnormal | 19.08 | 13.37 | 11 | 26318 | 1461 | 50577334 |
Caffeine allergy | 18.93 | 13.37 | 4 | 26325 | 21 | 50578774 |
Bronchiectasis | 18.90 | 13.37 | 25 | 26304 | 10258 | 50568537 |
Type I hypersensitivity | 18.78 | 13.37 | 13 | 26316 | 2372 | 50576423 |
Retinal vasculitis | 18.68 | 13.37 | 9 | 26320 | 829 | 50577966 |
Respiratory moniliasis | 18.61 | 13.37 | 6 | 26323 | 188 | 50578607 |
Polyneuropathy | 18.56 | 13.37 | 27 | 26302 | 12104 | 50566691 |
Back pain | 18.50 | 13.37 | 56 | 26273 | 219974 | 50358821 |
Implant site hypersensitivity | 18.48 | 13.37 | 4 | 26325 | 24 | 50578771 |
Swelling | 18.45 | 13.37 | 49 | 26280 | 200823 | 50377972 |
Pupillary disorder | 18.40 | 13.37 | 6 | 26323 | 195 | 50578600 |
Peripheral swelling | 18.35 | 13.37 | 51 | 26278 | 205885 | 50372910 |
Hypertransaminasaemia | 18.04 | 13.37 | 15 | 26314 | 3596 | 50575199 |
Bronchopulmonary aspergillosis | 18.04 | 13.37 | 21 | 26308 | 7571 | 50571224 |
Enterococcal infection | 17.95 | 13.37 | 20 | 26309 | 6878 | 50571917 |
Keratitis fungal | 17.93 | 13.37 | 5 | 26324 | 94 | 50578701 |
Discomfort | 17.86 | 13.37 | 18 | 26311 | 108362 | 50470433 |
Macular cyst | 17.82 | 13.37 | 4 | 26325 | 29 | 50578766 |
Death | 17.82 | 13.37 | 98 | 26231 | 325281 | 50253514 |
Chest discomfort | 17.66 | 13.37 | 95 | 26234 | 92627 | 50486168 |
Fatigue | 17.60 | 13.37 | 261 | 26068 | 707340 | 49871455 |
Hyperalbuminaemia | 17.37 | 13.37 | 4 | 26325 | 33 | 50578762 |
Visual impairment | 17.36 | 13.37 | 76 | 26253 | 68199 | 50510596 |
Vomiting | 17.34 | 13.37 | 336 | 25993 | 460422 | 50118373 |
Biopsy colon abnormal | 17.23 | 13.37 | 5 | 26324 | 109 | 50578686 |
Corneal neovascularisation | 17.23 | 13.37 | 5 | 26324 | 109 | 50578686 |
Eye discharge | 17.17 | 13.37 | 17 | 26312 | 5106 | 50573689 |
Rubber sensitivity | 16.99 | 13.37 | 11 | 26318 | 1798 | 50576997 |
Rash morbilliform | 16.73 | 13.37 | 13 | 26316 | 2833 | 50575962 |
Myelosuppression | 16.36 | 13.37 | 27 | 26302 | 13490 | 50565305 |
Musculoskeletal stiffness | 16.33 | 13.37 | 26 | 26303 | 128455 | 50450340 |
Pneumonia haemophilus | 15.97 | 13.37 | 7 | 26322 | 519 | 50578276 |
Sleep apnoea syndrome | 15.83 | 13.37 | 37 | 26292 | 23831 | 50554964 |
Iridocyclitis | 15.74 | 13.37 | 11 | 26318 | 2038 | 50576757 |
Tendon rupture | 15.72 | 13.37 | 19 | 26310 | 7125 | 50571670 |
Pain in extremity | 15.59 | 13.37 | 81 | 26248 | 272784 | 50306011 |
Anterior chamber fibrin | 15.58 | 13.37 | 4 | 26325 | 54 | 50578741 |
Wound haemorrhage | 15.55 | 13.37 | 11 | 26318 | 2079 | 50576716 |
Lacrimation increased | 15.50 | 13.37 | 30 | 26299 | 16962 | 50561833 |
Blister | 15.48 | 13.37 | 13 | 26316 | 85405 | 50493390 |
Red blood cell count increased | 15.42 | 13.37 | 12 | 26317 | 2619 | 50576176 |
Limb mass | 15.25 | 13.37 | 12 | 26317 | 2663 | 50576132 |
Cardiac murmur | 15.07 | 13.37 | 23 | 26306 | 10761 | 50568034 |
Detachment of retinal pigment epithelium | 15.04 | 13.37 | 6 | 26323 | 351 | 50578444 |
Ventricular hypokinesia | 14.83 | 13.37 | 14 | 26315 | 3966 | 50574829 |
Gastrointestinal mucosa hyperaemia | 14.77 | 13.37 | 5 | 26324 | 183 | 50578612 |
Metamorphopsia | 14.60 | 13.37 | 8 | 26321 | 963 | 50577832 |
Hypertension | 14.58 | 13.37 | 171 | 26158 | 211032 | 50367763 |
Productive cough | 14.43 | 13.37 | 60 | 26269 | 52634 | 50526161 |
Corneal deposits | 14.30 | 13.37 | 5 | 26324 | 202 | 50578593 |
Anaphylactic shock | 14.20 | 13.37 | 32 | 26297 | 20123 | 50558672 |
Malignant neoplasm progression | 14.12 | 13.37 | 9 | 26320 | 68115 | 50510680 |
Retinal artery occlusion | 13.86 | 13.37 | 9 | 26320 | 1478 | 50577317 |
Type IV hypersensitivity reaction | 13.86 | 13.37 | 11 | 26318 | 2471 | 50576324 |
Hydrothorax | 13.77 | 13.37 | 7 | 26322 | 724 | 50578071 |
Enterocolitis | 13.70 | 13.37 | 17 | 26312 | 6550 | 50572245 |
Muscle spasms | 13.63 | 13.37 | 28 | 26301 | 125525 | 50453270 |
Eosinophilia | 13.57 | 13.37 | 30 | 26299 | 18622 | 50560173 |
Suicide attempt | 13.51 | 13.37 | 5 | 26324 | 51727 | 50527068 |
Allergic cough | 13.43 | 13.37 | 6 | 26323 | 465 | 50578330 |
Hyperhidrosis | 13.39 | 13.37 | 86 | 26243 | 89340 | 50489455 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Visual acuity reduced | 221.95 | 14.01 | 129 | 18052 | 14747 | 29541599 |
Eye pain | 179.46 | 14.01 | 103 | 18078 | 11492 | 29544854 |
Choroiditis | 166.80 | 14.01 | 49 | 18132 | 939 | 29555407 |
Intraocular pressure increased | 161.25 | 14.01 | 72 | 18109 | 4717 | 29551629 |
Iris transillumination defect | 157.06 | 14.01 | 25 | 18156 | 3 | 29556343 |
Endophthalmitis | 150.37 | 14.01 | 59 | 18122 | 2789 | 29553557 |
Toxic anterior segment syndrome | 147.29 | 14.01 | 45 | 18136 | 991 | 29555355 |
Delirium | 144.53 | 14.01 | 148 | 18033 | 39249 | 29517097 |
Electrocardiogram QT prolonged | 144.03 | 14.01 | 142 | 18039 | 35995 | 29520351 |
Uveitis | 131.63 | 14.01 | 67 | 18114 | 5880 | 29550466 |
Corneal oedema | 130.59 | 14.01 | 42 | 18139 | 1100 | 29555246 |
Drug resistance | 119.70 | 14.01 | 102 | 18079 | 21438 | 29534908 |
Mental disorder | 101.54 | 14.01 | 75 | 18106 | 12830 | 29543516 |
Ulcerative keratitis | 95.03 | 14.01 | 35 | 18146 | 1388 | 29554958 |
Hypopyon | 94.69 | 14.01 | 25 | 18156 | 317 | 29556029 |
Off label use | 92.49 | 14.01 | 397 | 17784 | 300403 | 29255943 |
Dysphoria | 85.27 | 14.01 | 36 | 18145 | 2056 | 29554290 |
Anterior chamber cell | 74.59 | 14.01 | 20 | 18161 | 270 | 29556076 |
Hepatotoxicity | 74.46 | 14.01 | 72 | 18109 | 17795 | 29538551 |
Neuropathy peripheral | 74.19 | 14.01 | 146 | 18035 | 70881 | 29485465 |
Paradoxical drug reaction | 72.89 | 14.01 | 35 | 18146 | 2706 | 29553640 |
Retinal haemorrhage | 72.31 | 14.01 | 41 | 18140 | 4463 | 29551883 |
Corneal infiltrates | 72.13 | 14.01 | 17 | 18164 | 130 | 29556216 |
Iridocyclitis | 69.62 | 14.01 | 28 | 18153 | 1412 | 29554934 |
Musculoskeletal injury | 69.25 | 14.01 | 16 | 18165 | 111 | 29556235 |
Mycotic allergy | 66.93 | 14.01 | 18 | 18163 | 246 | 29556100 |
Vitritis | 65.21 | 14.01 | 22 | 18159 | 671 | 29555675 |
Spirometry abnormal | 64.97 | 14.01 | 19 | 18162 | 358 | 29555988 |
Mite allergy | 63.67 | 14.01 | 18 | 18163 | 299 | 29556047 |
Iris hypopigmentation | 59.88 | 14.01 | 12 | 18169 | 37 | 29556309 |
Conjunctivitis allergic | 58.67 | 14.01 | 20 | 18161 | 630 | 29555716 |
Ototoxicity | 57.42 | 14.01 | 25 | 18156 | 1540 | 29554806 |
Dust allergy | 55.97 | 14.01 | 18 | 18163 | 471 | 29555875 |
Product use in unapproved indication | 54.47 | 14.01 | 146 | 18035 | 86729 | 29469617 |
Painful respiration | 53.91 | 14.01 | 22 | 18159 | 1152 | 29555194 |
Conjunctival hyperaemia | 49.89 | 14.01 | 25 | 18156 | 2120 | 29554226 |
Walking aid user | 49.05 | 14.01 | 22 | 18159 | 1455 | 29554891 |
Pathogen resistance | 48.29 | 14.01 | 40 | 18141 | 8076 | 29548270 |
Multiple-drug resistance | 48.22 | 14.01 | 30 | 18151 | 3870 | 29552476 |
Drug reaction with eosinophilia and systemic symptoms | 46.92 | 14.01 | 71 | 18110 | 27921 | 29528425 |
Visual impairment | 46.49 | 14.01 | 73 | 18108 | 29635 | 29526711 |
Chest injury | 46.49 | 14.01 | 21 | 18160 | 1412 | 29554934 |
Keratitis fungal | 45.58 | 14.01 | 10 | 18171 | 53 | 29556293 |
Corneal perforation | 44.82 | 14.01 | 12 | 18169 | 161 | 29556185 |
Skin injury | 44.67 | 14.01 | 19 | 18162 | 1105 | 29555241 |
Corneal epithelium defect | 40.04 | 14.01 | 13 | 18168 | 351 | 29555995 |
Corneal opacity | 39.42 | 14.01 | 14 | 18167 | 499 | 29555847 |
Death | 39.38 | 14.01 | 96 | 18085 | 341988 | 29214358 |
Tendonitis | 38.78 | 14.01 | 35 | 18146 | 7926 | 29548420 |
Condition aggravated | 38.62 | 14.01 | 185 | 17996 | 146110 | 29410236 |
Iris atrophy | 37.72 | 14.01 | 9 | 18172 | 73 | 29556273 |
Vision blurred | 36.48 | 14.01 | 78 | 18103 | 40098 | 29516248 |
Tendon discomfort | 36.27 | 14.01 | 11 | 18170 | 236 | 29556110 |
Diastasis recti abdominis | 35.87 | 14.01 | 7 | 18174 | 18 | 29556328 |
Hypoacusis | 35.38 | 14.01 | 44 | 18137 | 14379 | 29541967 |
NPM1 gene mutation | 33.88 | 14.01 | 9 | 18172 | 117 | 29556229 |
Oral candidiasis | 33.45 | 14.01 | 37 | 18144 | 10685 | 29545661 |
Cystoid macular oedema | 32.95 | 14.01 | 13 | 18168 | 623 | 29555723 |
Cataract | 32.28 | 14.01 | 53 | 18128 | 22325 | 29534021 |
Asthma | 32.21 | 14.01 | 67 | 18114 | 33782 | 29522564 |
Vitreous opacities | 32.11 | 14.01 | 10 | 18171 | 235 | 29556111 |
Tuberculoma of central nervous system | 31.99 | 14.01 | 10 | 18171 | 238 | 29556108 |
Bronchiolitis obliterans syndrome | 31.21 | 14.01 | 9 | 18172 | 161 | 29556185 |
Sleep disorder due to a general medical condition | 31.03 | 14.01 | 21 | 18160 | 3125 | 29553221 |
Intentional product use issue | 30.28 | 14.01 | 75 | 18106 | 42423 | 29513923 |
Urethritis mycoplasmal | 30.06 | 14.01 | 6 | 18175 | 18 | 29556328 |
Ocular hyperaemia | 29.34 | 14.01 | 32 | 18149 | 9095 | 29547251 |
Overdose | 28.49 | 14.01 | 7 | 18174 | 79812 | 29476534 |
Chimerism | 28.49 | 14.01 | 9 | 18172 | 222 | 29556124 |
Keratic precipitates | 28.46 | 14.01 | 8 | 18173 | 130 | 29556216 |
Keratitis bacterial | 28.11 | 14.01 | 7 | 18174 | 69 | 29556277 |
Infective keratitis | 28.04 | 14.01 | 5 | 18176 | 6 | 29556340 |
Acute myeloid leukaemia recurrent | 28.02 | 14.01 | 16 | 18165 | 1764 | 29554582 |
Tendon pain | 27.84 | 14.01 | 18 | 18163 | 2482 | 29553864 |
Retinal detachment | 27.67 | 14.01 | 23 | 18158 | 4663 | 29551683 |
Acoustic neuroma | 27.64 | 14.01 | 8 | 18173 | 145 | 29556201 |
Eye abscess | 27.59 | 14.01 | 8 | 18173 | 146 | 29556200 |
Persistent corneal epithelial defect | 27.32 | 14.01 | 6 | 18175 | 32 | 29556314 |
Drug-induced liver injury | 26.91 | 14.01 | 48 | 18133 | 21607 | 29534739 |
Toxicity to various agents | 26.64 | 14.01 | 41 | 18140 | 173620 | 29382726 |
Corynebacterium infection | 26.55 | 14.01 | 10 | 18171 | 422 | 29555924 |
Pigment dispersion syndrome | 26.49 | 14.01 | 5 | 18176 | 10 | 29556336 |
Tuberculosis | 26.28 | 14.01 | 27 | 18154 | 7169 | 29549177 |
Necrotising scleritis | 26.05 | 14.01 | 6 | 18175 | 41 | 29556305 |
Aortic aneurysm | 25.78 | 14.01 | 25 | 18156 | 6195 | 29550151 |
Product dose omission issue | 25.11 | 14.01 | 14 | 18167 | 96369 | 29459977 |
Flat anterior chamber of eye | 24.69 | 14.01 | 6 | 18175 | 53 | 29556293 |
Sitting disability | 24.61 | 14.01 | 7 | 18174 | 119 | 29556227 |
Corneal scar | 24.08 | 14.01 | 7 | 18174 | 129 | 29556217 |
Tinnitus | 23.91 | 14.01 | 38 | 18143 | 15576 | 29540770 |
Anterior chamber inflammation | 23.84 | 14.01 | 8 | 18173 | 240 | 29556106 |
Fibrin | 23.34 | 14.01 | 4 | 18177 | 3 | 29556343 |
Mycobacterium chelonae infection | 23.24 | 14.01 | 10 | 18171 | 598 | 29555748 |
Detachment of retinal pigment epithelium | 23.20 | 14.01 | 9 | 18172 | 412 | 29555934 |
Conjunctival oedema | 22.88 | 14.01 | 9 | 18172 | 428 | 29555918 |
Deafness unilateral | 22.34 | 14.01 | 14 | 18167 | 1829 | 29554517 |
Dehydration | 21.83 | 14.01 | 23 | 18158 | 114725 | 29441621 |
Vitreous haemorrhage | 21.21 | 14.01 | 14 | 18167 | 1999 | 29554347 |
Photophobia | 21.00 | 14.01 | 22 | 18159 | 5973 | 29550373 |
Foreign body sensation in eyes | 20.83 | 14.01 | 9 | 18172 | 544 | 29555802 |
Axonal neuropathy | 20.45 | 14.01 | 10 | 18171 | 804 | 29555542 |
Deafness neurosensory | 20.30 | 14.01 | 15 | 18166 | 2563 | 29553783 |
Immune reconstitution inflammatory syndrome associated tuberculosis | 19.90 | 14.01 | 8 | 18173 | 403 | 29555943 |
Blood immunoglobulin G decreased | 19.82 | 14.01 | 11 | 18170 | 1148 | 29555198 |
Corneal transplant | 19.58 | 14.01 | 5 | 18176 | 55 | 29556291 |
Herpes zoster meningoencephalitis | 19.33 | 14.01 | 7 | 18174 | 264 | 29556082 |
Blepharitis allergic | 19.19 | 14.01 | 3 | 18178 | 0 | 29556346 |
Chondritis | 19.15 | 14.01 | 6 | 18175 | 144 | 29556202 |
Cardiovascular disorder | 18.39 | 14.01 | 25 | 18156 | 8910 | 29547436 |
Drug hypersensitivity | 18.36 | 14.01 | 87 | 18094 | 68319 | 29488027 |
Metamorphopsia | 18.35 | 14.01 | 8 | 18173 | 494 | 29555852 |
Drug ineffective for unapproved indication | 18.29 | 14.01 | 32 | 18149 | 14182 | 29542164 |
Incorrect product administration duration | 18.19 | 14.01 | 17 | 18164 | 4024 | 29552322 |
Immune reconstitution inflammatory syndrome | 17.86 | 14.01 | 23 | 18158 | 7779 | 29548567 |
Haematospermia | 17.85 | 14.01 | 7 | 18174 | 330 | 29556016 |
Optic neuritis | 17.82 | 14.01 | 15 | 18166 | 3094 | 29553252 |
Mechanical urticaria | 17.63 | 14.01 | 5 | 18176 | 84 | 29556262 |
Deafness | 17.54 | 14.01 | 26 | 18155 | 10029 | 29546317 |
Torsade de pointes | 17.43 | 14.01 | 21 | 18160 | 6640 | 29549706 |
Masticatory pain | 17.04 | 14.01 | 4 | 18177 | 30 | 29556316 |
Pulmonary venous thrombosis | 16.96 | 14.01 | 5 | 18176 | 97 | 29556249 |
Nervous system disorder | 16.92 | 14.01 | 29 | 18152 | 12645 | 29543701 |
Hospitalisation | 16.47 | 14.01 | 4 | 18177 | 45984 | 29510362 |
Cerebrovascular accident | 16.27 | 14.01 | 14 | 18167 | 76897 | 29479449 |
Emotional distress | 16.24 | 14.01 | 30 | 18151 | 13865 | 29542481 |
Hypersomnia | 16.23 | 14.01 | 26 | 18155 | 10728 | 29545618 |
Transaminases increased | 16.14 | 14.01 | 40 | 18141 | 22622 | 29533724 |
Eye discharge | 16.08 | 14.01 | 11 | 18170 | 1665 | 29554681 |
Eye oedema | 16.03 | 14.01 | 8 | 18173 | 672 | 29555674 |
Disorganised speech | 16.00 | 14.01 | 8 | 18173 | 675 | 29555671 |
Choroidal haematoma | 15.89 | 14.01 | 3 | 18178 | 6 | 29556340 |
Ocular icterus | 15.78 | 14.01 | 13 | 18168 | 2602 | 29553744 |
Vitreous floaters | 15.75 | 14.01 | 14 | 18167 | 3107 | 29553239 |
Pupillary disorder | 15.69 | 14.01 | 6 | 18175 | 264 | 29556082 |
Papilloma | 15.69 | 14.01 | 5 | 18176 | 127 | 29556219 |
Incision site pain | 15.47 | 14.01 | 11 | 18170 | 1772 | 29554574 |
Toxic optic neuropathy | 15.38 | 14.01 | 8 | 18173 | 733 | 29555613 |
Product delivery mechanism issue | 15.36 | 14.01 | 5 | 18176 | 136 | 29556210 |
Hallucination | 15.15 | 14.01 | 61 | 18120 | 44651 | 29511695 |
Mycobacterial infection | 15.07 | 14.01 | 11 | 18170 | 1845 | 29554501 |
Neurilemmoma benign | 15.03 | 14.01 | 3 | 18178 | 9 | 29556337 |
Phosphorus metabolism disorder | 15.03 | 14.01 | 3 | 18178 | 9 | 29556337 |
Feeling cold | 14.95 | 14.01 | 23 | 18158 | 9168 | 29547178 |
Scleral thinning | 14.79 | 14.01 | 3 | 18178 | 10 | 29556336 |
Pruritus genital | 14.67 | 14.01 | 7 | 18174 | 533 | 29555813 |
Corneal disorder | 14.65 | 14.01 | 8 | 18173 | 809 | 29555537 |
Pneumothorax | 14.65 | 14.01 | 31 | 18150 | 15811 | 29540535 |
Eye infection fungal | 14.61 | 14.01 | 6 | 18175 | 319 | 29556027 |
Eyelid oedema | 14.46 | 14.01 | 16 | 18165 | 4620 | 29551726 |
Fall | 14.44 | 14.01 | 58 | 18123 | 177120 | 29379226 |
Retinal oedema | 14.40 | 14.01 | 7 | 18174 | 556 | 29555790 |
Punctate keratitis | 14.35 | 14.01 | 6 | 18175 | 334 | 29556012 |
Malabsorption from administration site | 14.23 | 14.01 | 4 | 18177 | 65 | 29556281 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Toxic anterior segment syndrome | 361.44 | 12.22 | 110 | 40540 | 2329 | 64455753 |
Iris transillumination defect | 358.60 | 12.22 | 64 | 40586 | 74 | 64458008 |
Endophthalmitis | 297.64 | 12.22 | 116 | 40534 | 5249 | 64452833 |
Corneal oedema | 285.59 | 12.22 | 91 | 40559 | 2252 | 64455830 |
Visual acuity reduced | 275.32 | 12.22 | 186 | 40464 | 26955 | 64431127 |
Electrocardiogram QT prolonged | 235.61 | 12.22 | 270 | 40380 | 79178 | 64378904 |
Hypopyon | 230.58 | 12.22 | 64 | 40586 | 965 | 64457117 |
Contrast media allergy | 227.76 | 12.22 | 75 | 40575 | 2066 | 64456016 |
Drug resistance | 203.15 | 12.22 | 172 | 40478 | 34930 | 64423152 |
Eye pain | 201.83 | 12.22 | 164 | 40486 | 31461 | 64426621 |
Drug hypersensitivity | 193.52 | 12.22 | 448 | 40202 | 237367 | 64220715 |
Intraocular pressure increased | 174.22 | 12.22 | 91 | 40559 | 8211 | 64449871 |
Ulcerative keratitis | 164.87 | 12.22 | 65 | 40585 | 3032 | 64455050 |
Corneal infiltrates | 160.33 | 12.22 | 37 | 40613 | 248 | 64457834 |
Delirium | 154.67 | 12.22 | 204 | 40446 | 68990 | 64389092 |
Choroiditis | 148.23 | 12.22 | 46 | 40604 | 1041 | 64457041 |
Mental disorder | 133.69 | 12.22 | 120 | 40530 | 26325 | 64431757 |
Dysphoria | 127.43 | 12.22 | 60 | 40590 | 4328 | 64453754 |
Corneal opacity | 122.15 | 12.22 | 38 | 40612 | 867 | 64457215 |
Corneal epithelium defect | 119.28 | 12.22 | 35 | 40615 | 650 | 64457432 |
Off label use | 117.69 | 12.22 | 740 | 39910 | 632066 | 63826016 |
Anterior chamber cell | 117.13 | 12.22 | 36 | 40614 | 788 | 64457294 |
Neuropathy peripheral | 113.04 | 12.22 | 237 | 40413 | 117288 | 64340794 |
Vitritis | 109.92 | 12.22 | 40 | 40610 | 1493 | 64456589 |
Paradoxical drug reaction | 108.56 | 12.22 | 60 | 40590 | 6060 | 64452022 |
Uveitis | 105.34 | 12.22 | 77 | 40573 | 12631 | 64445451 |
Drug reaction with eosinophilia and systemic symptoms | 103.28 | 12.22 | 148 | 40502 | 54069 | 64404013 |
Obliterative bronchiolitis | 98.13 | 12.22 | 43 | 40607 | 2622 | 64455460 |
Corneal perforation | 97.72 | 12.22 | 30 | 40620 | 654 | 64457428 |
Conjunctival hyperaemia | 94.18 | 12.22 | 47 | 40603 | 3852 | 64454230 |
Hepatotoxicity | 91.08 | 12.22 | 119 | 40531 | 39843 | 64418239 |
Pigment dispersion syndrome | 90.84 | 12.22 | 16 | 40634 | 16 | 64458066 |
Iris hypopigmentation | 81.07 | 12.22 | 16 | 40634 | 43 | 64458039 |
Ocular hyperaemia | 79.47 | 12.22 | 84 | 40566 | 22480 | 64435602 |
Asthma | 79.00 | 12.22 | 181 | 40469 | 95044 | 64363038 |
Iris atrophy | 75.71 | 12.22 | 17 | 40633 | 99 | 64457983 |
Ototoxicity | 75.29 | 12.22 | 36 | 40614 | 2687 | 64455395 |
Iridocyclitis | 74.42 | 12.22 | 37 | 40613 | 3008 | 64455074 |
Pathogen resistance | 73.64 | 12.22 | 62 | 40588 | 12481 | 64445601 |
Vision blurred | 73.08 | 12.22 | 170 | 40480 | 90146 | 64367936 |
Torsade de pointes | 72.76 | 12.22 | 71 | 40579 | 17292 | 64440790 |
Tuberculoma of central nervous system | 69.51 | 12.22 | 22 | 40628 | 532 | 64457550 |
Tendonitis | 68.77 | 12.22 | 74 | 40576 | 20208 | 64437874 |
Spirometry abnormal | 68.66 | 12.22 | 22 | 40628 | 554 | 64457528 |
Tinnitus | 66.20 | 12.22 | 94 | 40556 | 34039 | 64424043 |
Musculoskeletal injury | 64.02 | 12.22 | 16 | 40634 | 156 | 64457926 |
Anaphylactic reaction | 63.11 | 12.22 | 136 | 40514 | 68528 | 64389554 |
Drug intolerance | 62.28 | 12.22 | 259 | 40391 | 187733 | 64270349 |
Loss of employment | 61.36 | 12.22 | 28 | 40622 | 1879 | 64456203 |
Oesophageal spasm | 59.70 | 12.22 | 30 | 40620 | 2495 | 64455587 |
Retinal haemorrhage | 59.45 | 12.22 | 44 | 40606 | 7354 | 64450728 |
Tendon pain | 58.35 | 12.22 | 37 | 40613 | 4811 | 64453271 |
Death | 58.27 | 12.22 | 137 | 40513 | 482568 | 63975514 |
Multiple-drug resistance | 57.54 | 12.22 | 41 | 40609 | 6461 | 64451621 |
Punctate keratitis | 56.23 | 12.22 | 21 | 40629 | 844 | 64457238 |
Toxicity to various agents | 55.25 | 12.22 | 90 | 40560 | 363423 | 64094659 |
Total lung capacity increased | 52.73 | 12.22 | 19 | 40631 | 689 | 64457393 |
Sputum purulent | 52.46 | 12.22 | 22 | 40628 | 1204 | 64456878 |
Dust allergy | 52.21 | 12.22 | 21 | 40629 | 1032 | 64457050 |
Visual impairment | 50.93 | 12.22 | 131 | 40519 | 73946 | 64384136 |
Asthma-chronic obstructive pulmonary disease overlap syndrome | 50.87 | 12.22 | 21 | 40629 | 1104 | 64456978 |
Corneal disorder | 50.63 | 12.22 | 25 | 40625 | 2002 | 64456080 |
Upper respiratory tract infection | 50.34 | 12.22 | 129 | 40521 | 72656 | 64385426 |
Arthropathy | 50.26 | 12.22 | 8 | 40642 | 120959 | 64337123 |
Nicotine dependence | 50.14 | 12.22 | 19 | 40631 | 795 | 64457287 |
Conjunctivitis allergic | 49.21 | 12.22 | 20 | 40630 | 1010 | 64457072 |
Drug-induced liver injury | 49.20 | 12.22 | 99 | 40551 | 47544 | 64410538 |
Product use in unapproved indication | 48.41 | 12.22 | 230 | 40420 | 176388 | 64281694 |
Keratitis fungal | 48.40 | 12.22 | 13 | 40637 | 172 | 64457910 |
Synovitis | 47.50 | 12.22 | 4 | 40646 | 99086 | 64358996 |
Bronchitis chronic | 47.30 | 12.22 | 30 | 40620 | 3902 | 64454180 |
Infective keratitis | 47.05 | 12.22 | 10 | 40640 | 43 | 64458039 |
Persistent corneal epithelial defect | 47.05 | 12.22 | 10 | 40640 | 43 | 64458039 |
Vitreous opacities | 46.88 | 12.22 | 16 | 40634 | 493 | 64457589 |
Anterior chamber disorder | 46.62 | 12.22 | 12 | 40638 | 133 | 64457949 |
Product dose omission issue | 46.49 | 12.22 | 33 | 40617 | 194714 | 64263368 |
Acinetobacter infection | 46.36 | 12.22 | 25 | 40625 | 2404 | 64455678 |
Mite allergy | 44.99 | 12.22 | 17 | 40633 | 706 | 64457376 |
Photophobia | 43.34 | 12.22 | 54 | 40596 | 17239 | 64440843 |
Wheezing | 42.12 | 12.22 | 129 | 40521 | 80450 | 64377632 |
Oesophageal pain | 42.03 | 12.22 | 26 | 40624 | 3237 | 64454845 |
Foreign body sensation in eyes | 42.00 | 12.22 | 21 | 40629 | 1728 | 64456354 |
Fibrin | 41.24 | 12.22 | 8 | 40642 | 19 | 64458063 |
Chest injury | 40.82 | 12.22 | 23 | 40627 | 2410 | 64455672 |
Corneal flap complication | 40.26 | 12.22 | 7 | 40643 | 6 | 64458076 |
Mycotic allergy | 39.68 | 12.22 | 17 | 40633 | 981 | 64457101 |
Dehydration | 38.51 | 12.22 | 48 | 40602 | 216715 | 64241367 |
Tendon discomfort | 37.44 | 12.22 | 13 | 40637 | 422 | 64457660 |
NPM1 gene mutation | 37.39 | 12.22 | 10 | 40640 | 130 | 64457952 |
Fall | 37.36 | 12.22 | 136 | 40514 | 416690 | 64041392 |
Full blood count abnormal | 37.09 | 12.22 | 67 | 40583 | 29690 | 64428392 |
Nasal polyps | 37.08 | 12.22 | 25 | 40625 | 3604 | 64454478 |
Cataract | 36.63 | 12.22 | 92 | 40558 | 51170 | 64406912 |
Keratitis bacterial | 36.58 | 12.22 | 10 | 40640 | 142 | 64457940 |
Psoriasis | 35.81 | 12.22 | 113 | 40537 | 71590 | 64386492 |
Painful respiration | 35.80 | 12.22 | 23 | 40627 | 3058 | 64455024 |
Systemic lupus erythematosus | 34.92 | 12.22 | 4 | 40646 | 77608 | 64380474 |
Dysbiosis | 34.78 | 12.22 | 15 | 40635 | 880 | 64457202 |
Deafness | 34.77 | 12.22 | 50 | 40600 | 18309 | 64439773 |
Diastasis recti abdominis | 34.66 | 12.22 | 7 | 40643 | 22 | 64458060 |
Overdose | 34.34 | 12.22 | 30 | 40620 | 159536 | 64298546 |
Pupillary disorder | 33.12 | 12.22 | 12 | 40638 | 442 | 64457640 |
Hallucination | 33.01 | 12.22 | 111 | 40539 | 72677 | 64385405 |
Skin injury | 32.96 | 12.22 | 19 | 40631 | 2080 | 64456002 |
Optic neuritis | 31.80 | 12.22 | 32 | 40618 | 8084 | 64449998 |
Hyponatraemia | 31.79 | 12.22 | 28 | 40622 | 148311 | 64309771 |
Lymphoedema | 31.59 | 12.22 | 35 | 40615 | 9870 | 64448212 |
Factor V deficiency | 31.14 | 12.22 | 8 | 40642 | 88 | 64457994 |
Bronchiolitis obliterans syndrome | 31.13 | 12.22 | 10 | 40640 | 254 | 64457828 |
Secondary immunodeficiency | 30.83 | 12.22 | 20 | 40630 | 2704 | 64455378 |
Chimerism | 30.69 | 12.22 | 10 | 40640 | 266 | 64457816 |
Retinal detachment | 30.43 | 12.22 | 31 | 40619 | 7945 | 64450137 |
Cystoid macular oedema | 30.39 | 12.22 | 17 | 40633 | 1757 | 64456325 |
Urethritis mycoplasmal | 29.91 | 12.22 | 6 | 40644 | 18 | 64458064 |
Alopecia | 29.09 | 12.22 | 37 | 40613 | 165653 | 64292429 |
Suicide attempt | 28.81 | 12.22 | 5 | 40645 | 71002 | 64387080 |
Stenotrophomonas infection | 28.59 | 12.22 | 20 | 40630 | 3060 | 64455022 |
Hypoacusis | 28.20 | 12.22 | 55 | 40595 | 25812 | 64432270 |
Immune reconstitution inflammatory syndrome | 28.19 | 12.22 | 37 | 40613 | 12433 | 64445649 |
Retinal ischaemia | 27.76 | 12.22 | 12 | 40638 | 708 | 64457374 |
Eye pruritus | 27.75 | 12.22 | 37 | 40613 | 12622 | 64445460 |
Polyneuropathy | 27.66 | 12.22 | 47 | 40603 | 19847 | 64438235 |
Treatment failure | 27.65 | 12.22 | 146 | 40504 | 116670 | 64341412 |
Obstructive airways disorder | 27.38 | 12.22 | 51 | 40599 | 23134 | 64434948 |
Corneal transplant | 27.25 | 12.22 | 9 | 40641 | 250 | 64457832 |
Flat anterior chamber of eye | 27.14 | 12.22 | 8 | 40642 | 151 | 64457931 |
Forced expiratory volume decreased | 26.77 | 12.22 | 27 | 40623 | 6840 | 64451242 |
Optic neuropathy | 26.67 | 12.22 | 19 | 40631 | 2992 | 64455090 |
Tendon rupture | 25.99 | 12.22 | 33 | 40617 | 10734 | 64447348 |
Maternal exposure during pregnancy | 25.98 | 12.22 | 14 | 40636 | 95870 | 64362212 |
Peripheral nerve injury | 25.84 | 12.22 | 11 | 40639 | 625 | 64457457 |
Non-infectious endophthalmitis | 25.81 | 12.22 | 9 | 40641 | 296 | 64457786 |
Eye abscess | 25.78 | 12.22 | 9 | 40641 | 297 | 64457785 |
Acute myeloid leukaemia recurrent | 25.66 | 12.22 | 18 | 40632 | 2766 | 64455316 |
Hyperkalaemia | 25.65 | 12.22 | 16 | 40634 | 101113 | 64356969 |
Bronchial ulceration | 25.48 | 12.22 | 4 | 40646 | 0 | 64458082 |
Metamorphopsia | 25.45 | 12.22 | 13 | 40637 | 1119 | 64456963 |
Retinal vasculitis | 25.29 | 12.22 | 13 | 40637 | 1134 | 64456948 |
Hypotension | 25.25 | 12.22 | 139 | 40511 | 380835 | 64077247 |
Eye oedema | 25.08 | 12.22 | 15 | 40635 | 1758 | 64456324 |
Herpes zoster | 24.55 | 12.22 | 107 | 40543 | 79080 | 64379002 |
Sleep disorder due to a general medical condition | 24.39 | 12.22 | 28 | 40622 | 8206 | 64449876 |
Corynebacterium infection | 24.30 | 12.22 | 12 | 40638 | 961 | 64457121 |
Iris adhesions | 24.24 | 12.22 | 10 | 40640 | 525 | 64457557 |
Acoustic neuroma | 24.00 | 12.22 | 8 | 40642 | 229 | 64457853 |
Cerebrovascular accident | 23.86 | 12.22 | 31 | 40619 | 137552 | 64320530 |
Bradycardia | 23.35 | 12.22 | 24 | 40626 | 118195 | 64339887 |
Conjunctival oedema | 23.29 | 12.22 | 12 | 40638 | 1052 | 64457030 |
Blepharitis allergic | 23.24 | 12.22 | 4 | 40646 | 3 | 64458079 |
Sitting disability | 22.96 | 12.22 | 7 | 40643 | 149 | 64457933 |
Corneal scar | 22.89 | 12.22 | 8 | 40642 | 265 | 64457817 |
Injection site erythema | 22.89 | 12.22 | 8 | 40642 | 70792 | 64387290 |
Aortic aneurysm | 22.85 | 12.22 | 26 | 40624 | 7548 | 64450534 |
Haemostasis | 22.75 | 12.22 | 8 | 40642 | 270 | 64457812 |
Fatigue | 22.69 | 12.22 | 334 | 40316 | 748396 | 63709686 |
Acute kidney injury | 22.65 | 12.22 | 178 | 40472 | 449062 | 64009020 |
Corneal thinning | 22.61 | 12.22 | 7 | 40643 | 157 | 64457925 |
Eye inflammation | 22.51 | 12.22 | 21 | 40629 | 4836 | 64453246 |
Lacrimation increased | 22.47 | 12.22 | 41 | 40609 | 18305 | 64439777 |
Skin reaction | 22.46 | 12.22 | 33 | 40617 | 12319 | 64445763 |
Nosocomial infection | 22.45 | 12.22 | 16 | 40634 | 2521 | 64455561 |
Keratic precipitates | 22.05 | 12.22 | 8 | 40642 | 296 | 64457786 |
Detachment of retinal pigment epithelium | 21.96 | 12.22 | 10 | 40640 | 668 | 64457414 |
Herpes zoster meningoencephalitis | 21.79 | 12.22 | 10 | 40640 | 680 | 64457402 |
Eye discharge | 21.69 | 12.22 | 21 | 40629 | 5063 | 64453019 |
Rhinitis allergic | 21.49 | 12.22 | 26 | 40624 | 8052 | 64450030 |
Necrotising scleritis | 21.28 | 12.22 | 7 | 40643 | 192 | 64457890 |
Vanishing bile duct syndrome | 21.23 | 12.22 | 12 | 40638 | 1265 | 64456817 |
Intentional product use issue | 21.08 | 12.22 | 117 | 40533 | 95247 | 64362835 |
Wound | 20.96 | 12.22 | 11 | 40639 | 76466 | 64381616 |
Immune reconstitution inflammatory syndrome associated tuberculosis | 20.71 | 12.22 | 10 | 40640 | 763 | 64457319 |
Headache | 20.56 | 12.22 | 224 | 40426 | 529243 | 63928839 |
Eye infection staphylococcal | 20.52 | 12.22 | 6 | 40644 | 110 | 64457972 |
Productive cough | 20.51 | 12.22 | 96 | 40554 | 73107 | 64384975 |
Anterior chamber pigmentation | 20.20 | 12.22 | 4 | 40646 | 11 | 64458071 |
Bronchitis | 19.92 | 12.22 | 127 | 40523 | 108616 | 64349466 |
Walking aid user | 19.70 | 12.22 | 22 | 40628 | 6259 | 64451823 |
Sputum discoloured | 19.50 | 12.22 | 38 | 40612 | 17818 | 64440264 |
Vitreal cells | 19.46 | 12.22 | 5 | 40645 | 55 | 64458027 |
Mediastinal effusion | 19.46 | 12.22 | 5 | 40645 | 55 | 64458027 |
Hepatic steatosis | 19.44 | 12.22 | 53 | 40597 | 30954 | 64427128 |
Haematospermia | 19.34 | 12.22 | 7 | 40643 | 257 | 64457825 |
Aqueous humour leakage | 19.11 | 12.22 | 3 | 40647 | 0 | 64458082 |
Gonioscopy abnormal | 19.11 | 12.22 | 3 | 40647 | 0 | 64458082 |
Incorrect product administration duration | 19.10 | 12.22 | 27 | 40623 | 9731 | 64448351 |
Nocardiosis | 19.05 | 12.22 | 19 | 40631 | 4748 | 64453334 |
Corneal neovascularisation | 18.96 | 12.22 | 6 | 40644 | 145 | 64457937 |
Gastroenteritis staphylococcal | 18.94 | 12.22 | 7 | 40643 | 273 | 64457809 |
Eye irritation | 18.87 | 12.22 | 35 | 40615 | 15821 | 64442261 |
Thrombocytopenia | 18.48 | 12.22 | 219 | 40431 | 223582 | 64234500 |
Increased viscosity of bronchial secretion | 18.42 | 12.22 | 8 | 40642 | 477 | 64457605 |
Injection site pain | 18.41 | 12.22 | 26 | 40624 | 111382 | 64346700 |
Corneal erosion | 18.40 | 12.22 | 7 | 40643 | 296 | 64457786 |
Drug ineffective for unapproved indication | 18.32 | 12.22 | 52 | 40598 | 31081 | 64427001 |
Morganella infection | 18.22 | 12.22 | 10 | 40640 | 996 | 64457086 |
Anterior chamber inflammation | 18.17 | 12.22 | 8 | 40642 | 493 | 64457589 |
Caffeine allergy | 18.16 | 12.22 | 4 | 40646 | 21 | 64458061 |
Forced vital capacity abnormal | 18.16 | 12.22 | 4 | 40646 | 21 | 64458061 |
Axonal neuropathy | 18.12 | 12.22 | 12 | 40638 | 1680 | 64456402 |
Oral candidiasis | 18.00 | 12.22 | 43 | 40607 | 23169 | 64434913 |
Rash morbilliform | 17.85 | 12.22 | 19 | 40631 | 5122 | 64452960 |
Mycobacterium chelonae infection | 17.82 | 12.22 | 13 | 40637 | 2124 | 64455958 |
Implant site hypersensitivity | 17.71 | 12.22 | 4 | 40646 | 24 | 64458058 |
Language disorder | 17.13 | 12.22 | 14 | 40636 | 2703 | 64455379 |
Pericarditis | 17.12 | 12.22 | 9 | 40641 | 62507 | 64395575 |
Stevens-Johnson syndrome | 17.12 | 12.22 | 54 | 40596 | 34195 | 64423887 |
Phosphorus metabolism disorder | 17.03 | 12.22 | 3 | 40647 | 3 | 64458079 |
Vitreous degeneration | 16.94 | 12.22 | 4 | 40646 | 30 | 64458052 |
Corneal deposits | 16.92 | 12.22 | 7 | 40643 | 370 | 64457712 |
Biopsy colon abnormal | 16.88 | 12.22 | 5 | 40645 | 96 | 64457986 |
Pneumothorax | 16.72 | 12.22 | 43 | 40607 | 24255 | 64433827 |
Sarcoidosis | 16.71 | 12.22 | 20 | 40630 | 6126 | 64451956 |
Cough | 16.58 | 12.22 | 275 | 40375 | 301873 | 64156209 |
Eosinophilic pneumonia acute | 16.57 | 12.22 | 9 | 40641 | 878 | 64457204 |
Masticatory pain | 16.50 | 12.22 | 4 | 40646 | 34 | 64458048 |
Blister | 16.49 | 12.22 | 16 | 40634 | 80951 | 64377131 |
Dysmetria | 16.48 | 12.22 | 9 | 40641 | 887 | 64457195 |
Multiple sclerosis relapse | 16.46 | 12.22 | 3 | 40647 | 41132 | 64416950 |
Lethargy | 16.41 | 12.22 | 13 | 40637 | 72581 | 64385501 |
Scleral thinning | 16.39 | 12.22 | 4 | 40646 | 35 | 64458047 |
Neoplasm progression | 16.37 | 12.22 | 3 | 40647 | 40961 | 64417121 |
Pulmonary venous thrombosis | 16.33 | 12.22 | 5 | 40645 | 108 | 64457974 |
Paraneoplastic syndrome | 16.33 | 12.22 | 9 | 40641 | 904 | 64457178 |
Anaphylactic shock | 16.25 | 12.22 | 49 | 40601 | 30279 | 64427803 |
Back pain | 16.16 | 12.22 | 92 | 40558 | 250079 | 64208003 |
Malignant neoplasm progression | 16.14 | 12.22 | 29 | 40621 | 112842 | 64345240 |
Vitreous floaters | 16.13 | 12.22 | 20 | 40630 | 6353 | 64451729 |
Choroidal neovascularisation | 16.06 | 12.22 | 7 | 40643 | 421 | 64457661 |
Toxic optic neuropathy | 16.02 | 12.22 | 9 | 40641 | 938 | 64457144 |
Hyperalbuminaemia | 15.83 | 12.22 | 4 | 40646 | 41 | 64458041 |
Tuberculosis | 15.79 | 12.22 | 29 | 40621 | 13009 | 64445073 |
Eyelid oedema | 15.75 | 12.22 | 28 | 40622 | 12251 | 64445831 |
Weight increased | 15.72 | 12.22 | 75 | 40575 | 213273 | 64244809 |
Eye infection fungal | 15.71 | 12.22 | 7 | 40643 | 444 | 64457638 |
Respiratory moniliasis | 15.61 | 12.22 | 6 | 40644 | 261 | 64457821 |
Vitreous haemorrhage | 15.58 | 12.22 | 14 | 40636 | 3071 | 64455011 |
Aqueous fibrin | 15.53 | 12.22 | 5 | 40645 | 128 | 64457954 |
Macular fibrosis | 15.47 | 12.22 | 8 | 40642 | 706 | 64457376 |
Respiratory arrest | 15.47 | 12.22 | 7 | 40643 | 52978 | 64405104 |
Incision site pain | 15.33 | 12.22 | 13 | 40637 | 2641 | 64455441 |
Cellulitis | 15.33 | 12.22 | 22 | 40628 | 93635 | 64364447 |
Ventricular tachycardia | 15.30 | 12.22 | 52 | 40598 | 34213 | 64423869 |
Rash erythematous | 15.29 | 12.22 | 66 | 40584 | 48567 | 64409515 |
Complications of transplant surgery | 15.22 | 12.22 | 8 | 40642 | 731 | 64457351 |
Blood immunoglobulin G decreased | 15.21 | 12.22 | 13 | 40637 | 2670 | 64455412 |
Urinary tract infection | 15.05 | 12.22 | 85 | 40565 | 231511 | 64226571 |
Nervous system disorder | 15.02 | 12.22 | 40 | 40610 | 23038 | 64435044 |
Cutis laxa | 14.97 | 12.22 | 5 | 40645 | 144 | 64457938 |
Chondritis | 14.87 | 12.22 | 5 | 40645 | 147 | 64457935 |
Suspected counterfeit product | 14.84 | 12.22 | 7 | 40643 | 507 | 64457575 |
Anterior chamber flare | 14.74 | 12.22 | 5 | 40645 | 151 | 64457931 |
Coronary artery disease | 14.72 | 12.22 | 10 | 40640 | 60423 | 64397659 |
Dysdiadochokinesis | 14.61 | 12.22 | 6 | 40644 | 311 | 64457771 |
Chest discomfort | 14.61 | 12.22 | 124 | 40526 | 115982 | 64342100 |
Injection site swelling | 14.57 | 12.22 | 4 | 40646 | 41349 | 64416733 |
AIDS related complication | 14.55 | 12.22 | 4 | 40646 | 58 | 64458024 |
Choroidal detachment | 14.48 | 12.22 | 7 | 40643 | 535 | 64457547 |
Retinal artery occlusion | 14.32 | 12.22 | 13 | 40637 | 2890 | 64455192 |
Anterior chamber fibrin | 14.29 | 12.22 | 5 | 40645 | 166 | 64457916 |
Neurilemmoma benign | 14.29 | 12.22 | 3 | 40647 | 12 | 64458070 |
Discomfort | 14.25 | 12.22 | 18 | 40632 | 80860 | 64377222 |
Erythema of eyelid | 14.25 | 12.22 | 11 | 40639 | 1957 | 64456125 |
Embolism venous | 14.06 | 12.22 | 14 | 40636 | 3493 | 64454589 |
Haematemesis | 14.05 | 12.22 | 6 | 40644 | 46993 | 64411089 |
Muscle spasms | 13.97 | 12.22 | 44 | 40606 | 140979 | 64317103 |
Limb mass | 13.88 | 12.22 | 13 | 40637 | 3008 | 64455074 |
Disorganised speech | 13.68 | 12.22 | 10 | 40640 | 1640 | 64456442 |
Hyperglycaemia | 13.68 | 12.22 | 11 | 40639 | 60957 | 64397125 |
Scleral disorder | 13.65 | 12.22 | 5 | 40645 | 190 | 64457892 |
Ocular hypertension | 13.64 | 12.22 | 9 | 40641 | 1252 | 64456830 |
Sinus pain | 13.58 | 12.22 | 12 | 40638 | 2577 | 64455505 |
Cardio-respiratory arrest | 13.43 | 12.22 | 26 | 40624 | 98367 | 64359715 |
Bronchopulmonary aspergillosis | 13.36 | 12.22 | 34 | 40616 | 19051 | 64439031 |
Foreign body in eye | 13.32 | 12.22 | 5 | 40645 | 204 | 64457878 |
Musculoskeletal stiffness | 13.24 | 12.22 | 37 | 40613 | 123169 | 64334913 |
Tendon disorder | 13.11 | 12.22 | 18 | 40632 | 6314 | 64451768 |
Pain in extremity | 13.07 | 12.22 | 125 | 40525 | 302960 | 64155122 |
Gastrointestinal mucosa hyperaemia | 12.94 | 12.22 | 6 | 40644 | 418 | 64457664 |
Cryptococcosis | 12.94 | 12.22 | 12 | 40638 | 2743 | 64455339 |
Ocular icterus | 12.90 | 12.22 | 16 | 40634 | 5082 | 64453000 |
Intentional product misuse | 12.83 | 12.22 | 16 | 40634 | 72279 | 64385803 |
Vestibular disorder | 12.77 | 12.22 | 11 | 40639 | 2282 | 64455800 |
Hypotony of eye | 12.77 | 12.22 | 5 | 40645 | 229 | 64457853 |
Injection site pruritus | 12.70 | 12.22 | 4 | 40646 | 37822 | 64420260 |
Skin odour abnormal | 12.58 | 12.22 | 10 | 40640 | 1857 | 64456225 |
Disseminated mycobacterium avium complex infection | 12.40 | 12.22 | 4 | 40646 | 103 | 64457979 |
Injection site reaction | 12.37 | 12.22 | 7 | 40643 | 46657 | 64411425 |
Allergic cough | 12.35 | 12.22 | 6 | 40644 | 464 | 64457618 |
Rash | 12.31 | 12.22 | 377 | 40273 | 458172 | 63999910 |
FEV1/FVC ratio abnormal | 12.22 | 12.22 | 3 | 40647 | 27 | 64458055 |
None
Source | Code | Description |
---|---|---|
ATC | J01MA14 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE QUINOLONE ANTIBACTERIALS Fluoroquinolones |
ATC | S01AE07 | SENSORY ORGANS OPHTHALMOLOGICALS ANTIINFECTIVES Fluoroquinolones |
FDA CS | M0023650 | Quinolones |
MeSH PA | D000900 | Anti-Bacterial Agents |
MeSH PA | D000890 | Anti-Infective Agents |
MeSH PA | D000970 | Antineoplastic Agents |
MeSH PA | D004791 | Enzyme Inhibitors |
MeSH PA | D059005 | Topoisomerase II Inhibitors |
CHEBI has role | CHEBI:36047 | antibacterial drugs |
FDA EPC | N0000175937 | Quinolone Antimicrobial |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Septicemic plague | indication | 9012003 | DOID:3481 |
Infection of skin AND/OR subcutaneous tissue | indication | 19824006 | |
Staphylococcal pneumonia | indication | 22754005 | |
Pneumonia due to Streptococcus | indication | 34020007 | |
Pneumonic plague | indication | 38976008 | DOID:10398 |
Pneumonia due to Mycoplasma pneumoniae | indication | 46970008 | |
Peritonitis | indication | 48661000 | |
Bacterial pneumonia | indication | 53084003 | DOID:874 |
Pneumonia due to Klebsiella pneumoniae | indication | 64479007 | |
Haemophilus influenzae pneumonia | indication | 70036007 | |
Rhinoscleroma | indication | 72409005 | DOID:11336 |
Abdominal abscess | indication | 75100008 | |
Acute bacterial sinusitis | indication | 75498004 | |
Infectious disease of abdomen | indication | 128070006 | |
Bacterial conjunctivitis | indication | 128350005 | DOID:9700 |
Infection due to Enterobacteriaceae | indication | 128945009 | |
Bacterial infection due to Klebsiella pneumoniae | indication | 186435004 | |
Pneumococcal pneumonia | indication | 233607000 | |
Chlamydial pneumonia | indication | 233609002 | |
Streptococcus pyogenes infection | indication | 302809008 | |
Infection due to Staphylococcus aureus | indication | 406602003 | |
Acute exacerbation of chronic bronchitis | indication | 425748003 | |
Complicated Skin and Skin Structure E. Coli Infection | indication | ||
Complicated Skin and Skin Structure Infection | indication | ||
Haemophilus Influenzae Chronic Bronchitis | indication | ||
Complicated Skin and Skin Structure Staphylococcus Aureus Infection | indication | ||
Haemophilus Parainfluenzae Chronic Bronchitis | indication | ||
Streptococcus Pneumoniae Chronic Bronchitis | indication | ||
Moraxella Catarrhalis Pneumonia | indication | ||
Staphylococcus Chronic Bronchitis | indication | ||
Klebsiella Pneumoniae Chronic Bronchitis | indication | ||
Moraxella Catarrhalis Chronic Bronchitis | indication | ||
Acute tuberculosis | off-label use | 25629007 | |
Pulmonary tuberculosis | off-label use | 154283005 | DOID:2957 |
Cirrhosis of liver | contraindication | 19943007 | DOID:5082 |
Torsades de pointes | contraindication | 31722008 | |
Transplantation of heart | contraindication | 32413006 | |
Tendinitis | contraindication | 34840004 | DOID:971 |
Hypokalemia | contraindication | 43339004 | |
Conduction disorder of the heart | contraindication | 44808001 | |
Bradycardia | contraindication | 48867003 | |
Transplant of kidney | contraindication | 70536003 | |
Epilepsy | contraindication | 84757009 | DOID:1826 |
Transplant of lung | contraindication | 88039007 | |
Myasthenia gravis | contraindication | 91637004 | DOID:437 |
Prolonged QT interval | contraindication | 111975006 | |
Liver function tests abnormal | contraindication | 166603001 | |
Drug-induced hepatitis | contraindication | 235876009 | |
Peripheral nerve disease | contraindication | 302226006 | |
Pseudomembranous enterocolitis | contraindication | 397683000 | |
Myocardial ischemia | contraindication | 414795007 | DOID:3393 |
Traumatic rupture of tendon | contraindication | 415749005 | |
Congenital long QT syndrome | contraindication | 442917000 | |
Severe Cerebral Arteriosclerosis | contraindication |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 6.23 | acidic |
pKa2 | 8.54 | Basic |
pKa3 | 2.92 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Topoisomerase IV | Enzyme | INHIBITOR | CHEMBL | CHEMBL | |||||
DNA gyrase | Enzyme | INHIBITOR | IC50 | 6.52 | CHEMBL | CHEMBL | |||
DNA topoisomerase 4 subunit A | Enzyme | IC50 | 6.10 | CHEMBL | |||||
DNA gyrase subunit A | Enzyme | IC50 | 5.04 | CHEMBL |
ID | Source |
---|---|
D00874 | KEGG_DRUG |
186826-86-8 | SECONDARY_CAS_RN |
4021185 | VANDF |
4021186 | VANDF |
C0536495 | UMLSCUI |
CHEBI:63611 | CHEBI |
MFX | PDB_CHEM_ID |
CHEMBL32 | ChEMBL_ID |
CHEMBL1200735 | ChEMBL_ID |
D000077266 | MESH_DESCRIPTOR_UI |
DB00218 | DRUGBANK_ID |
152946 | PUBCHEM_CID |
10915 | IUPHAR_LIGAND_ID |
7659 | INN_ID |
U188XYD42P | UNII |
1047505 | RXNORM |
178916 | MMSL |
213098 | MMSL |
31558 | MMSL |
35332 | MMSL |
8580 | MMSL |
d04500 | MMSL |
007927 | NDDF |
007928 | NDDF |
116347002 | SNOMEDCT_US |
371296007 | SNOMEDCT_US |
412439003 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
MOXEZA | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0065-0006 | SOLUTION | 5 mg | OPHTHALMIC | NDA | 23 sections |
VIGAMOX | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0065-4013 | SOLUTION/ DROPS | 5 mg | OPHTHALMIC | NDA | 25 sections |
VIGAMOX | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0065-4013 | SOLUTION/ DROPS | 5 mg | OPHTHALMIC | NDA | 25 sections |
VIGAMOX | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0078-0939 | SOLUTION/ DROPS | 5 mg | OPHTHALMIC | NDA | 25 sections |
Moxifloxacin Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-7387 | TABLET, FILM COATED | 400 mg | ORAL | ANDA | 28 sections |
Moxifloxacin Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0093-7387 | TABLET, FILM COATED | 400 mg | ORAL | ANDA | 28 sections |
Moxifloxacin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0378-5430 | SOLUTION/ DROPS | 5 mg | OPHTHALMIC | ANDA | 24 sections |
Moxifloxacin Ophthalmic Solution | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0781-7135 | SOLUTION/ DROPS | 5 mg | OPHTHALMIC | NDA authorized generic | 25 sections |
Moxifloxacin Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0832-1410 | SOLUTION | 5 mg | OPHTHALMIC | ANDA | 26 sections |
Moxifloxacin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6406 | TABLET, FILM COATED | 400 mg | ORAL | ANDA | 30 sections |
Moxifloxacin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0904-6406 | TABLET, FILM COATED | 400 mg | ORAL | ANDA | 30 sections |
moxifloxacin hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-201 | TABLET | 400 mg | ORAL | ANDA | 29 sections |
moxifloxacin hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 13668-201 | TABLET | 400 mg | ORAL | ANDA | 29 sections |
Avelox ABC Pack | HUMAN PRESCRIPTION DRUG LABEL | 1 | 16590-881 | TABLET, FILM COATED | 400 mg | ORAL | NDA | 17 sections |
Moxifloxacin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 17478-519 | SOLUTION/ DROPS | 5 mg | OPHTHALMIC | ANDA | 25 sections |
VIGAMOX | HUMAN PRESCRIPTION DRUG LABEL | 1 | 21695-968 | SOLUTION | 5 mg | OPHTHALMIC | NDA | 20 sections |
Moxifloxacin Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 40032-034 | TABLET | 400 mg | ORAL | ANDA | 28 sections |
Moxifloxacin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-3147 | TABLET, FILM COATED | 400 mg | ORAL | ANDA | 30 sections |
Moxifloxacin Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-4058 | TABLET | 400 mg | ORAL | ANDA | 32 sections |
Moxifloxacin Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-4100 | TABLET | 400 mg | ORAL | ANDA | 32 sections |
Moxifloxacin ophthalmic solution | Human Prescription Drug Label | 1 | 50090-4781 | SOLUTION/ DROPS | 5 mg | OPHTHALMIC | ANDA | 24 sections |
Moxifloxacin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50090-5279 | SOLUTION/ DROPS | 5 mg | OPHTHALMIC | ANDA | 24 sections |
Moxifloxacin Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50268-576 | TABLET, FILM COATED | 400 mg | ORAL | ANDA | 30 sections |
Moxifloxacin Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 50268-576 | TABLET, FILM COATED | 400 mg | ORAL | ANDA | 30 sections |
Moxifloxacin Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 51991-943 | TABLET | 400 mg | ORAL | ANDA | 33 sections |
Moxifloxacin ophthalmic solution | Human Prescription Drug Label | 1 | 53002-2626 | SOLUTION/ DROPS | 5 mg | OPHTHALMIC | ANDA | 24 sections |
Avelox | HUMAN PRESCRIPTION DRUG LABEL | 1 | 54868-4367 | TABLET, FILM COATED | 400 mg | ORAL | NDA | 30 sections |
VIGAMOX | HUMAN PRESCRIPTION DRUG LABEL | 1 | 54868-4798 | SOLUTION | 5 mg | OPHTHALMIC | NDA | 24 sections |
Moxifloxacin | HUMAN PRESCRIPTION DRUG LABEL | 1 | 55111-112 | TABLET, FILM COATED | 400 mg | ORAL | ANDA | 30 sections |
Moxifloxacin Hydrochloride | Human Prescription Drug Label | 1 | 57237-156 | TABLET, FILM COATED | 400 mg | ORAL | ANDA | 29 sections |