All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

moxifloxacin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
antibacterials, nalidixic acid derivatives	1854	151096-09-2

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: avelox moxifloxacin moxifloxacin hydrochloride avolex moxeza moxifloxacine moxifloxacin HCl	A fluoroquinolone that acts as an inhibitor of DNA TOPOISOMERASE II and is used as a broad-spectrum antibacterial agent. Molecular weight: 401.44 Formula: C21H24FN3O4 CLOGP: -0.12 LIPINSKI: 0 HAC: 7 HDO: 2 TPSA: 82.11 ALOGS: -3.38 ROTB: 4 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Drug dosage:

Dose	Unit	Route
0.40	g	O
0.40	g	P

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	3	Benet LZ, Broccatelli F, Oprea TI
S (Water solubility)	27.50 mg/mL	Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine)	22 %	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	14.23 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability)	86 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution)	1.40 L/kg	Lombardo F, Berellini G, Obach RS
CL (Clearance)	2.40 mL/min/kg	Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)	0.60 %	Lombardo F, Berellini G, Obach RS
t_half (Half-life)	8.20 hours	Lombardo F, Berellini G, Obach RS

Approvals:

Date	Agency	Company	Orphan
Dec. 10, 1999	FDA	BAYER HLTHCARE

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Drug hypersensitivity	433.28	12.67	718	37883	309969	63140452
Iris transillumination defect	310.60	12.67	54	38547	50	63450371
Contrast media allergy	299.08	12.67	94	38507	2307	63448114
Toxic anterior segment syndrome	265.80	12.67	80	38521	1691	63448730
Endophthalmitis	192.48	12.67	75	38526	3517	63446904
Corneal oedema	175.79	12.67	56	38545	1437	63448984
Drug resistance	161.08	12.67	124	38477	22809	63427612
Asthma	158.84	12.67	281	38320	127280	63323141
Asthma-chronic obstructive pulmonary disease overlap syndrome	158.08	12.67	56	38545	2005	63448416
Hypopyon	154.01	12.67	43	38558	689	63449732
Total lung capacity increased	140.86	12.67	53	38548	2257	63448164
Wheezing	132.64	12.67	221	38380	95374	63355047
Obliterative bronchiolitis	131.15	12.67	49	38552	2046	63448375
Electrocardiogram QT prolonged	130.95	12.67	171	38430	59359	63391062
Loss of employment	117.22	12.67	46	38555	2198	63448223
Torsade de pointes	115.83	12.67	82	38519	13269	63437152
Nasal polyps	105.78	12.67	58	38543	5981	63444440
Corneal opacity	104.80	12.67	32	38569	711	63449710
Upper respiratory tract infection	101.09	12.67	180	38421	81867	63368554
Corneal infiltrates	99.99	12.67	22	38579	120	63450301
Visual acuity reduced	99.49	12.67	92	38509	21734	63428687
Food allergy	96.54	12.67	69	38532	11332	63439089
Eye pain	91.71	12.67	108	38493	33746	63416675
Oesophageal spasm	86.89	12.67	41	38560	3082	63447339
Sarcoidosis	86.63	12.67	54	38547	7068	63443353
Corneal epithelium defect	84.80	12.67	23	38578	329	63450092
Paradoxical drug reaction	81.46	12.67	43	38558	4109	63446312
Musculoskeletal injury	80.49	12.67	18	38583	107	63450314
Psoriasis	79.27	12.67	168	38433	86789	63363632
Drug intolerance	76.96	12.67	381	38220	308280	63142141
Pigment dispersion syndrome	76.87	12.67	12	38589	0	63450421
Temperature regulation disorder	75.86	12.67	47	38554	6085	63444336
Hepatic steatosis	74.99	12.67	90	38511	28679	63421742
Oesophageal pain	74.52	12.67	39	38562	3662	63446759
Nasal oedema	71.84	12.67	29	38572	1493	63448928
Lymphoedema	70.89	12.67	58	38543	11634	63438787
Nicotine dependence	68.66	12.67	23	38578	694	63449727
Rhinitis allergic	66.58	12.67	56	38545	11671	63438750
Sputum purulent	66.50	12.67	25	38576	1062	63449359
Ulcerative keratitis	64.58	12.67	32	38569	2678	63447743
Vitritis	61.36	12.67	23	38578	969	63449452
Acinetobacter infection	60.68	12.67	26	38575	1557	63448864
Immunodeficiency	60.55	12.67	68	38533	20186	63430235
Cough	59.04	12.67	341	38260	292402	63158019
Anaphylactic reaction	58.26	12.67	126	38475	65974	63384447
Mental disorder	57.81	12.67	75	38526	25844	63424577
Drug reaction with eosinophilia and systemic symptoms	56.22	12.67	85	38516	33751	63416670
Rash erythematous	55.88	12.67	96	38505	42414	63408007
Drug-induced liver injury	55.74	12.67	93	38508	40129	63410292
Cardiac murmur	54.37	12.67	55	38546	14497	63435924
Anterior chamber cell	54.28	12.67	18	38583	526	63449895
Secondary immunodeficiency	53.95	12.67	23	38578	1360	63449061
Bronchiectasis	53.12	12.67	57	38544	16085	63434336
Tinnitus	51.56	12.67	84	38517	35544	63414877
Iris hypopigmentation	50.48	12.67	9	38592	11	63450410
Ocular hyperaemia	50.31	12.67	69	38532	25075	63425346
Tuberculoma of central nervous system	49.18	12.67	15	38586	332	63450089
Alopecia	48.19	12.67	82	38519	337454	63112967
Jaundice cholestatic	47.94	12.67	38	38563	7286	63443135
Iris atrophy	47.77	12.67	11	38590	76	63450345
Pneumonia	47.76	12.67	455	38146	456312	62994109
Systemic lupus erythematosus	47.02	12.67	35	38566	208883	63241538
Herpes zoster	46.98	12.67	133	38468	82329	63368092
Product dose omission issue	46.89	12.67	44	38557	234269	63216152
Thrombocytopenia	46.79	12.67	199	38402	150958	63299463
Hepatotoxicity	46.53	12.67	82	38519	36959	63413462
Skin reaction	46.36	12.67	51	38550	14798	63435623
Corneal perforation	46.28	12.67	16	38585	532	63449889
Conjunctival hyperaemia	44.87	12.67	24	38577	2355	63448066
Vision blurred	44.54	12.67	140	38461	91784	63358637
Punctate keratitis	44.33	12.67	16	38585	605	63449816
Dysphoria	44.23	12.67	31	38570	4935	63445486
Coeliac disease	43.54	12.67	46	38555	12751	63437670
Anterior chamber disorder	43.46	12.67	11	38590	118	63450303
Off label use	43.25	12.67	611	37990	673851	62776570
Hypomania	41.77	12.67	33	38568	6297	63444124
Cataract	41.69	12.67	101	38500	56952	63393469
Treatment failure	41.48	12.67	234	38367	198809	63251612
Neuropathy peripheral	41.04	12.67	157	38444	113510	63336911
Photophobia	40.85	12.67	52	38549	17583	63432838
Pemphigus	39.78	12.67	32	38569	183694	63266727
Lung neoplasm malignant	39.47	12.67	54	38547	19579	63430842
Toxicity to various agents	39.15	12.67	56	38545	247194	63203227
Corneal disorder	39.06	12.67	20	38581	1794	63448627
Bronchitis chronic	38.36	12.67	27	38574	4326	63446095
Fluid retention	37.71	12.67	100	38501	59586	63390835
Forced expiratory volume decreased	37.38	12.67	28	38573	4940	63445481
Hyperhidrosis	37.34	12.67	147	38454	107689	63342732
Eye inflammation	36.54	12.67	29	38572	5570	63444851
Gastric disorder	36.13	12.67	74	38527	37295	63413126
Blood immunoglobulin A decreased	35.75	12.67	17	38584	1300	63449121
Hypertension	35.74	12.67	291	38310	279012	63171409
Glossodynia	35.30	12.67	34	38567	178842	63271579
Ototoxicity	35.20	12.67	17	38584	1345	63449076
Blood immunoglobulin M increased	34.88	12.67	16	38585	1127	63449294
Multiple fractures	34.83	12.67	34	38567	8584	63441837
Foetal death	34.77	12.67	38	38563	10942	63439479
Maternal exposure during pregnancy	34.67	12.67	50	38551	220012	63230409
Allergy to metals	34.67	12.67	14	38587	721	63449700
Intraocular pressure increased	34.45	12.67	29	38572	6049	63444372
Bursitis	34.23	12.67	72	38529	36969	63413452
Stenotrophomonas infection	34.21	12.67	19	38582	2008	63448413
Death	33.59	12.67	116	38485	374265	63076156
Rash	33.47	12.67	502	38099	560369	62890052
Toxic epidermal necrolysis	33.01	12.67	57	38544	25277	63425144
Factor V deficiency	32.68	12.67	8	38593	74	63450347
Dysbiosis	31.85	12.67	14	38587	892	63449529
Skin injury	31.20	12.67	17	38584	1731	63448690
Retinal haemorrhage	30.86	12.67	25	38576	4944	63445477
Tendonitis	30.78	12.67	48	38553	19567	63430854
Schizophrenia	30.75	12.67	34	38567	9918	63440503
Corneal deposits	30.29	12.67	10	38591	288	63450133
Tendon pain	30.17	12.67	21	38580	3305	63447116
Choroiditis	29.95	12.67	9	38592	189	63450232
Sputum discoloured	29.94	12.67	43	38558	16304	63434117
Hand deformity	29.53	12.67	32	38569	159425	63290996
Vitreous opacities	29.38	12.67	10	38591	317	63450104
Vomiting	29.26	12.67	490	38111	559127	62891294
Pathogen resistance	29.21	12.67	27	38574	6371	63444050
Chronic obstructive pulmonary disease	29.01	12.67	94	38507	62592	63387829
Vanishing bile duct syndrome	27.98	12.67	12	38589	720	63449701
Gastroenteritis staphylococcal	27.83	12.67	7	38594	73	63450348
Psychotic disorder	27.36	12.67	53	38548	25659	63424762
Keratitis	27.35	12.67	20	38581	3402	63447019
Hypotension	26.84	12.67	81	38520	272523	63177898
Infective keratitis	26.64	12.67	6	38595	37	63450384
Gait disturbance	26.57	12.67	44	38557	183134	63267287
Persistent corneal epithelial defect	26.54	12.67	5	38596	10	63450411
Product monitoring error	26.53	12.67	22	38579	4494	63445927
Non-infectious endophthalmitis	26.31	12.67	8	38593	175	63450246
Sleep apnoea syndrome	26.19	12.67	56	38545	29077	63421344
Injection site erythema	26.06	12.67	9	38592	83165	63367256
Blood immunoglobulin G increased	26.03	12.67	17	38584	2410	63448011
Respiratory tract infection	25.69	12.67	69	38532	41414	63409007
Corneal flap complication	25.62	12.67	4	38597	0	63450421
Respiratory moniliasis	25.54	12.67	8	38593	194	63450227
Anterior chamber inflammation	25.51	12.67	9	38592	318	63450103
Iridocyclitis	25.43	12.67	17	38584	2505	63447916
Myelosuppression	25.39	12.67	49	38552	23654	63426767
Urinary tract infection	25.10	12.67	80	38521	264604	63185817
Eye infection staphylococcal	24.85	12.67	7	38594	116	63450305
Foreign body sensation in eyes	24.82	12.67	16	38585	2218	63448203
Dehydration	24.81	12.67	42	38559	173312	63277109
Eye pruritus	24.31	12.67	42	38559	18629	63431792
Eye irritation	24.25	12.67	46	38555	21925	63428496
Swelling	24.22	12.67	86	38515	275292	63175129
Dyspnoea	24.04	12.67	548	38053	660765	62789656
Haemostasis	23.86	12.67	8	38593	242	63450179
Fibrin	23.39	12.67	4	38597	3	63450418
Nosocomial infection	23.36	12.67	14	38587	1707	63448714
Eosinophilic pneumonia acute	23.19	12.67	9	38592	417	63450004
Optic neuritis	22.98	12.67	27	38574	8408	63442013
Wound	22.95	12.67	40	38561	163223	63287198
Glaucoma	22.65	12.67	41	38560	18864	63431557
Morganella infection	22.40	12.67	10	38591	661	63449760
Corneal erosion	22.35	12.67	8	38593	295	63450126
Arthropathy	22.23	12.67	71	38530	234721	63215700
Embolism venous	22.02	12.67	17	38584	3137	63447284
Fall	21.98	12.67	144	38457	392190	63058231
Full blood count abnormal	21.94	12.67	55	38546	31662	63418759
Injection site pain	21.94	12.67	28	38573	129772	63320649
Anti-cyclic citrullinated peptide antibody positive	21.87	12.67	23	38578	116189	63334232
Deafness	21.58	12.67	39	38562	17918	63432503
Increased viscosity of bronchial secretion	21.39	12.67	8	38593	335	63450086
Corneal abscess	21.18	12.67	5	38596	39	63450382
Bradycardia	21.15	12.67	9	38592	73218	63377203
Retinal ischaemia	21.10	12.67	8	38593	348	63450073
Ventricular tachycardia	21.03	12.67	41	38560	19938	63430483
Keratitis bacterial	20.85	12.67	5	38596	42	63450379
Malignant neoplasm progression	20.84	12.67	12	38589	82109	63368312
Hallucination	20.83	12.67	77	38524	54740	63395681
Iodine allergy	20.67	12.67	10	38591	794	63449627
Atypical mycobacterial infection	20.47	12.67	11	38590	1089	63449332
Rheumatic disorder	20.24	12.67	16	38585	3056	63447365
Coma	20.10	12.67	7	38594	64357	63386064
Paraneoplastic syndrome	19.89	12.67	9	38592	614	63449807
Mediastinal effusion	19.48	12.67	5	38596	57	63450364
Prescribed overdose	19.35	12.67	55	38546	34098	63416323
Discomfort	19.28	12.67	46	38555	167328	63283093
Peripheral nerve injury	19.26	12.67	8	38593	443	63449978
Bronchitis	19.22	12.67	136	38465	124799	63325622
Gonioscopy abnormal	19.22	12.67	3	38598	0	63450421
Bronchial ulceration	19.22	12.67	3	38598	0	63450421
Nervous system disorder	19.14	12.67	38	38563	18728	63431693
Stevens-Johnson syndrome	19.11	12.67	45	38556	24905	63425516
Cataract operation	19.05	12.67	20	38581	5502	63444919
Cystitis	19.05	12.67	75	38526	54916	63395505
Vaccination site haemorrhage	19.00	12.67	4	38597	17	63450404
Blister	18.99	12.67	31	38570	129783	63320638
Corneal transplant	18.88	12.67	7	38594	286	63450135
Retinal vasculitis	18.86	12.67	10	38591	964	63449457
Trichophytosis	18.80	12.67	5	38596	66	63450355
Sinus pain	18.77	12.67	16	38585	3394	63447027
Skin odour abnormal	18.68	12.67	12	38589	1654	63448767
Hyperkalaemia	18.54	12.67	5	38596	54198	63396223
Suicide attempt	18.39	12.67	7	38594	60911	63389510
Caffeine allergy	18.31	12.67	4	38597	21	63450400
Forced vital capacity abnormal	18	12.67	4	38597	23	63450398
Red blood cell count increased	17.95	12.67	15	38586	3097	63447324
Helicobacter infection	17.87	12.67	18	38583	92767	63357654
Vitreous floaters	17.78	12.67	20	38581	5946	63444475
Obstructive airways disorder	17.71	12.67	39	38562	20660	63429761
Cerebrovascular accident	17.54	12.67	24	38577	108000	63342421
Malaise	17.41	12.67	352	38249	415602	63034819
Cryptococcosis	17.25	12.67	10	38591	1147	63449274
Rales	17.11	12.67	29	38572	12668	63437753
Productive cough	17.11	12.67	80	38521	63128	63387293
Therapeutic response decreased	17.08	12.67	8	38593	61517	63388904
Blindness unilateral	17.04	12.67	20	38581	6221	63444200
Injection site swelling	17.02	12.67	4	38597	47568	63402853
Upper respiratory tract irritation	16.98	12.67	6	38595	213	63450208
Implant site hypersensitivity	16.97	12.67	4	38597	31	63450390
Pericarditis	16.93	12.67	34	38567	131545	63318876
Macular cyst	16.86	12.67	4	38597	32	63450389
Detachment of retinal pigment epithelium	16.83	12.67	7	38594	389	63450032
Pupillary disorder	16.80	12.67	6	38595	220	63450201
Type IV hypersensitivity reaction	16.78	12.67	14	38587	2884	63447537
Hyperalbuminaemia	16.75	12.67	4	38597	33	63450388
Duodenal ulcer perforation	16.70	12.67	17	38584	87192	63363229
Type I hypersensitivity	16.60	12.67	14	38587	2928	63447493
Optic neuropathy	16.52	12.67	12	38589	2020	63448401
Biopsy colon abnormal	16.46	12.67	5	38596	109	63450312
Gastrooesophageal reflux disease	16.43	12.67	107	38494	95532	63354889
Enterococcal infection	16.40	12.67	22	38579	7826	63442595
Corneal neovascularisation	16.33	12.67	5	38596	112	63450309
Electrolyte imbalance	16.25	12.67	37	38564	20039	63430382
Fatigue	16.19	12.67	414	38187	887614	62562807
Hypertransaminasaemia	16.12	12.67	20	38581	6589	63443832
Delirium	15.97	12.67	67	38534	50474	63399947
Medication error	15.79	12.67	6	38595	52278	63398143
Injection site reaction	15.65	12.67	8	38593	58516	63391905
Multiple sclerosis relapse	15.61	12.67	5	38596	48473	63401948
Allergic cough	15.54	12.67	8	38593	726	63449695
Breast conserving surgery	15.46	12.67	9	38592	1040	63449381
Urticaria	15.23	12.67	161	38440	165641	63284780
Rhabdomyolysis	15.13	12.67	4	38597	43947	63406474
Nerve block	15.06	12.67	8	38593	774	63449647
Anterior chamber fibrin	14.96	12.67	4	38597	54	63450367
Multiple use of single-use product	14.91	12.67	10	38591	1482	63448939
Product used for unknown indication	14.85	12.67	7	38594	525	63449896
Bronchopulmonary aspergillosis	14.78	12.67	22	38579	8613	63441808
Sepsis	14.70	12.67	46	38555	153077	63297344
Keratitis fungal	14.59	12.67	5	38596	162	63450259
Aspergillus infection	14.40	12.67	21	38580	8072	63442349
Pruritus allergic	14.38	12.67	10	38591	1572	63448849
Hypoventilation	14.27	12.67	16	38585	4738	63445683
Eye discharge	14.23	12.67	18	38583	6045	63444376
Muscle spasms	14.23	12.67	48	38553	156102	63294319
Polyneuropathy	14.23	12.67	29	38572	14560	63435861
Retinal artery occlusion	13.98	12.67	10	38591	1643	63448778
Obstruction	13.90	12.67	13	38588	3114	63447307
Keratopathy	13.87	12.67	7	38594	609	63449812
Chest discomfort	13.72	12.67	114	38487	109855	63340566
Oedema	13.71	12.67	104	38497	97518	63352903
Acute kidney injury	13.58	12.67	99	38502	263316	63187105
Gastrointestinal mucosa hyperaemia	13.56	12.67	5	38596	201	63450220
Corneal defect	13.54	12.67	3	38598	17	63450404
Limb mass	13.53	12.67	13	38588	3219	63447202
Musculoskeletal stiffness	13.48	12.67	62	38539	184556	63265865
Atrial fibrillation	13.47	12.67	32	38569	116604	63333817
Circumstance or information capable of leading to medication error	13.32	12.67	14	38587	3856	63446565
Back pain	13.27	12.67	100	38501	264045	63186376
Pneumonia haemophilus	13.27	12.67	7	38594	668	63449753
Rash morbilliform	13.22	12.67	13	38588	3312	63447109
Thrombosis	13.12	12.67	12	38589	64743	63385678
Contusion	13.08	12.67	47	38554	149997	63300424
Pulmonary function test abnormal	13.07	12.67	10	38591	1820	63448601
Somnolence	13.05	12.67	60	38541	178625	63271796
Rubber sensitivity	12.96	12.67	11	38590	2320	63448101
Vitreous degeneration	12.87	12.67	3	38598	22	63450399
Pyelonephritis chronic	12.70	12.67	5	38596	241	63450180
Corneal infection	12.69	12.67	4	38597	99	63450322

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Visual acuity reduced	248.00	13.32	143	21475	16006	34919307
Choroiditis	225.76	13.32	65	21553	1150	34934163
Eye pain	206.13	13.32	119	21499	13343	34921970
Toxic anterior segment syndrome	201.52	13.32	59	21559	1110	34934203
Intraocular pressure increased	193.88	13.32	85	21533	5298	34930015
Electrocardiogram QT prolonged	177.58	13.32	169	21449	40783	34894530
Iris transillumination defect	176.06	13.32	28	21590	3	34935310
Corneal oedema	167.85	13.32	53	21565	1298	34934015
Endophthalmitis	165.09	13.32	67	21551	3441	34931872
Delirium	152.88	13.32	161	21457	43830	34891483
Uveitis	146.57	13.32	78	21540	7457	34927856
Drug resistance	145.96	13.32	124	21494	25803	34909510
Mycotic allergy	119.56	13.32	34	21584	574	34934739
Spirometry abnormal	118.04	13.32	35	21583	689	34934624
Mite allergy	114.73	13.32	34	21584	668	34934645
Sleep disorder due to a general medical condition	107.08	13.32	56	21562	5165	34930148
Dust allergy	106.18	13.32	34	21584	872	34934441
Conjunctivitis allergic	105.41	13.32	36	21582	1134	34934179
Off label use	103.30	13.32	521	21097	419003	34516310
Mental disorder	102.93	13.32	81	21537	15128	34920185
Anterior chamber cell	101.69	13.32	27	21591	348	34934965
Hypopyon	100.24	13.32	27	21591	369	34934944
Ulcerative keratitis	98.79	13.32	38	21580	1691	34933622
Dysphoria	94.89	13.32	40	21578	2262	34933051
Hepatotoxicity	75.22	13.32	79	21539	21406	34913907
Paradoxical drug reaction	71.74	13.32	37	21581	3314	34931999
Neuropathy peripheral	70.90	13.32	158	21460	83105	34852208
Corneal infiltrates	70.49	13.32	17	21601	144	34935169
Retinal haemorrhage	70.01	13.32	42	21576	5047	34930266
Corneal decompensation	68.36	13.32	12	21606	12	34935301
Musculoskeletal injury	67.49	13.32	16	21602	125	34935188
Iridocyclitis	65.74	13.32	28	21590	1624	34933689
Ototoxicity	64.92	13.32	29	21589	1888	34933425
Vitritis	63.39	13.32	23	21595	868	34934445
Asthma	61.11	13.32	101	21517	42555	34892758
Iris hypopigmentation	59.81	13.32	12	21606	37	34935276
Vitreous opacities	56.61	13.32	17	21601	350	34934963
Painful respiration	52.69	13.32	22	21596	1214	34934099
Pathogen resistance	52.60	13.32	45	21573	9437	34925876
Corneal perforation	52.06	13.32	14	21604	190	34935123
Product use in unapproved indication	51.72	13.32	175	21443	117324	34817989
Necrotising scleritis	48.23	13.32	11	21607	71	34935242
Conjunctival hyperaemia	47.08	13.32	25	21593	2377	34932936
Visual impairment	46.28	13.32	81	21537	35721	34899592
Normochromic normocytic anaemia	45.45	13.32	30	21588	4257	34931056
Death	44.81	13.32	114	21504	397935	34537378
Multiple-drug resistance	44.55	13.32	32	21586	5207	34930106
Chest injury	44.27	13.32	21	21597	1570	34933743
Immune reconstitution inflammatory syndrome	43.43	13.32	39	21579	8720	34926593
Walking aid user	43.38	13.32	22	21596	1902	34933411
Drug reaction with eosinophilia and systemic symptoms	41.78	13.32	74	21544	32938	34902375
Keratitis fungal	41.63	13.32	11	21607	139	34935174
Iris atrophy	41.43	13.32	10	21608	85	34935228
Nodule	41.20	13.32	34	21584	6785	34928528
Condition aggravated	40.32	13.32	229	21389	191967	34743346
Wheezing	40.30	13.32	83	21535	41319	34893994
Corneal epithelium defect	39.44	13.32	13	21605	366	34934947
Disorganised speech	38.21	13.32	16	21602	889	34934424
Corneal opacity	37.52	13.32	14	21604	572	34934741
Tendon discomfort	35.40	13.32	11	21607	255	34935058
Eye inflammation	34.97	13.32	20	21598	2198	34933115
Cystoid macular oedema	34.82	13.32	14	21604	701	34934612
Tendonitis	34.49	13.32	35	21583	9105	34926208
Hypoacusis	33.94	13.32	46	21572	16255	34919058
NPM1 gene mutation	33.82	13.32	9	21609	117	34935196
Drug ineffective for unapproved indication	33.74	13.32	56	21562	23659	34911654
Thalamic infarction	33.62	13.32	14	21604	767	34934546
Vision blurred	33.37	13.32	82	21536	45881	34889432
Ocular hyperaemia	32.95	13.32	38	21580	11414	34923899
Tachyarrhythmia	32.90	13.32	23	21595	3585	34931728
Retinal detachment	32.82	13.32	27	21591	5364	34929949
Tuberculosis	32.65	13.32	33	21585	8544	34926769
Persistent corneal epithelial defect	32.54	13.32	7	21611	33	34935280
Productive cough	32.41	13.32	72	21546	37741	34897572
Cataract	32.23	13.32	58	21560	26128	34909185
Product dose omission issue	32.10	13.32	17	21601	119694	34815619
Keratic precipitates	31.69	13.32	9	21609	151	34935162
Corneal scar	31.64	13.32	9	21609	152	34935161
Diastasis recti abdominis	31.57	13.32	7	21611	39	34935274
Skin injury	31.34	13.32	19	21599	2326	34932987
Tuberculoma of central nervous system	31.32	13.32	10	21608	254	34935059
Oral candidiasis	31.23	13.32	38	21580	12072	34923241
Vitreous haemorrhage	31.13	13.32	19	21599	2354	34932959
Anterior chamber inflammation	30.33	13.32	10	21608	282	34935031
Urethritis mycoplasmal	30.03	13.32	6	21612	18	34935295
Corynebacterium infection	29.62	13.32	12	21606	613	34934700
Bronchiolitis obliterans syndrome	29.45	13.32	9	21609	197	34935116
Tendon pain	29.45	13.32	20	21598	2975	34932338
Tuberculosis of central nervous system	29.41	13.32	9	21609	198	34935115
Flat anterior chamber of eye	29.38	13.32	7	21611	56	34935257
Drug-induced liver injury	28.28	13.32	58	21560	28774	34906539
Infective keratitis	28.01	13.32	5	21613	6	34935307
Chimerism	27.99	13.32	9	21609	234	34935079
Keratitis bacterial	27.55	13.32	7	21611	75	34935238
Overdose	27.40	13.32	11	21607	91048	34844265
Loss of personal independence in daily activities	27.12	13.32	62	21556	33117	34902196
Acoustic neuroma	26.86	13.32	8	21610	160	34935153
Eye abscess	26.86	13.32	8	21610	160	34935153
Pigment dispersion syndrome	26.46	13.32	5	21613	10	34935303
Full blood count abnormal	26.44	13.32	44	21574	18624	34916689
Dehydration	26.25	13.32	25	21593	129944	34805369
Acute myeloid leukaemia recurrent	25.00	13.32	16	21602	2154	34933159
Detachment of retinal pigment epithelium	24.70	13.32	10	21608	510	34934803
Scleromalacia	24.11	13.32	5	21613	19	34935294
Aortic aneurysm	23.84	13.32	25	21593	6754	34928559
Mycobacterium chelonae infection	23.42	13.32	11	21607	804	34934509
Fibrin	23.32	13.32	4	21614	3	34935310
Deafness neurosensory	23.19	13.32	17	21601	2854	34932459
Choroidal detachment	23.13	13.32	9	21609	413	34934900
Tinnitus	22.79	13.32	43	21575	20075	34915238
Toxicity to various agents	22.75	13.32	57	21561	200305	34735008
Conjunctival oedema	21.93	13.32	9	21609	475	34934838
Deafness unilateral	21.30	13.32	14	21604	1973	34933340
Sitting disability	21.24	13.32	7	21611	197	34935116
Corneal striae	21.17	13.32	4	21614	8	34935305
Vitreous haze	20.56	13.32	5	21613	44	34935269
Eye infection fungal	20.46	13.32	8	21610	372	34934941
Foreign body sensation in eyes	19.60	13.32	9	21609	625	34934688
Pulmonary venous thrombosis	19.48	13.32	6	21612	135	34935178
Blepharitis allergic	19.17	13.32	3	21615	0	34935313
Fall	19.16	13.32	63	21555	202822	34732491
Immune reconstitution inflammatory syndrome associated tuberculosis	19.01	13.32	8	21610	450	34934863
Nervous system disorder	18.91	13.32	33	21585	14510	34920803
Corneal transplant	18.79	13.32	5	21613	65	34935248
Intentional product use issue	18.74	13.32	80	21538	59736	34875577
Cerebrovascular accident	18.70	13.32	15	21603	84796	34850517
Arteriosclerosis coronary artery	18.45	13.32	30	21588	12455	34922858
Product delivery mechanism issue	18.44	13.32	6	21612	162	34935151
Chondritis	18.37	13.32	6	21612	164	34935149
Photophobia	18.19	13.32	22	21596	6942	34928371
Herpes zoster meningoencephalitis	18.10	13.32	7	21611	316	34934997
Trichoglossia	17.99	13.32	7	21611	321	34934992
Metamorphopsia	17.90	13.32	8	21610	521	34934792
Optic neuritis	17.89	13.32	16	21602	3558	34931755
Vitreous floaters	17.84	13.32	16	21602	3569	34931744
Axonal neuropathy	17.76	13.32	10	21608	1067	34934246
Feeling cold	17.71	13.32	27	21591	10612	34924701
Haematospermia	17.69	13.32	7	21611	336	34934977
Torsade de pointes	17.58	13.32	22	21596	7187	34928126
Cardiovascular disorder	17.42	13.32	26	21592	10030	34925283
Blood immunoglobulin G decreased	17.32	13.32	11	21607	1462	34933851
Masticatory pain	17.02	13.32	4	21614	30	34935283
Punctate keratitis	16.94	13.32	7	21611	376	34934937
Hypertension	16.93	13.32	37	21581	136406	34798907
FEV1/FVC ratio abnormal	16.79	13.32	4	21614	32	34935281
Corneal deposits	16.75	13.32	6	21612	218	34935095
Ocular icterus	16.75	13.32	14	21604	2843	34932470
Deafness	16.55	13.32	27	21591	11238	34924075
Cataract subcapsular	16.55	13.32	7	21611	399	34934914
Mechanical urticaria	16.42	13.32	5	21613	108	34935205
Retinal oedema	16.35	13.32	8	21610	640	34934673
Corneal disorder	16.29	13.32	9	21609	925	34934388
Retinal vasculitis	16.22	13.32	7	21611	419	34934894
Hydrocephalus	16.13	13.32	18	21600	5214	34930099
Idiopathic orbital inflammation	16.08	13.32	4	21614	39	34935274
Benign soft tissue neoplasm	16.05	13.32	5	21613	117	34935196
Choroidal haematoma	15.88	13.32	3	21615	6	34935307
Antibiotic associated colitis	15.88	13.32	3	21615	6	34935307
Incorrect product administration duration	15.61	13.32	17	21601	4794	34930519
Drug hypersensitivity	15.56	13.32	94	21524	80435	34854878
Transaminases increased	15.53	13.32	44	21574	26779	34908534
Prostate cancer	15.23	13.32	3	21615	39646	34895667
Incision site pain	15.11	13.32	11	21607	1827	34933486
Neurilemmoma benign	15.01	13.32	3	21615	9	34935304
Phosphorus metabolism disorder	15.01	13.32	3	21615	9	34935304
Suicide attempt	14.94	13.32	3	21615	39113	34896200
Myocardial infarction	14.88	13.32	33	21585	121052	34814261
Scleral thinning	14.77	13.32	3	21615	10	34935303
Hallucination	14.71	13.32	67	21551	51431	34883882
Mycobacterial infection	14.68	13.32	12	21606	2362	34932951
Tendon disorder	14.64	13.32	13	21605	2862	34932451
Mycobacterium abscessus infection	14.59	13.32	7	21611	537	34934776
Pupillary disorder	14.58	13.32	6	21612	319	34934994
Eye oedema	14.47	13.32	8	21610	824	34934489
Emotional distress	14.46	13.32	30	21588	14996	34920317
Intracardiac mass	14.42	13.32	5	21613	165	34935148
Ocular hypertension	14.36	13.32	8	21610	836	34934477
Toxic optic neuropathy	14.31	13.32	8	21610	842	34934471
Eye discharge	14.25	13.32	11	21607	1995	34933318
Hypotension	14.07	13.32	80	21538	221569	34713744
Obesity	13.94	13.32	27	21591	12851	34922462
Hypoxia	13.79	13.32	69	21549	55026	34880287
Anterior chamber disorder	13.77	13.32	4	21614	73	34935240
Anterior chamber flare	13.57	13.32	4	21614	77	34935236
Acute kidney injury	13.56	13.32	122	21496	304866	34630447
Hypersomnia	13.41	13.32	26	21592	12381	34922932

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Iris transillumination defect	421.66	12.10	76	54654	83	79689575
Toxic anterior segment syndrome	413.15	12.10	128	54602	2636	79687022
Corneal oedema	323.95	12.10	105	54625	2515	79687143
Endophthalmitis	314.38	12.10	130	54600	6298	79683360
Drug hypersensitivity	311.23	12.10	654	54076	298262	79391396
Visual acuity reduced	288.02	12.10	204	54526	29265	79660393
Electrocardiogram QT prolonged	248.14	12.10	308	54422	90078	79599580
Drug resistance	237.23	12.10	211	54519	42002	79647656
Choroiditis	236.45	12.10	71	54659	1310	79688348
Contrast media allergy	228.46	12.10	80	54650	2442	79687216
Hypopyon	227.42	12.10	66	54664	1076	79688582
Eye pain	213.47	12.10	189	54541	37389	79652269
Intraocular pressure increased	199.34	12.10	106	54624	9099	79680559
Asthma	179.64	12.10	328	54402	134767	79554891
Ulcerative keratitis	161.63	12.10	69	54661	3620	79686038
Wheezing	157.29	12.10	285	54445	116379	79573279
Corneal infiltrates	154.09	12.10	37	54693	273	79689385
Dysphoria	148.20	12.10	70	54660	4664	79684994
Anterior chamber cell	142.04	12.10	44	54686	905	79688753
Corneal opacity	138.91	12.10	44	54686	976	79688682
Delirium	135.34	12.10	223	54507	84404	79605254
Mental disorder	132.90	12.10	134	54596	31168	79658490
Paradoxical drug reaction	131.40	12.10	74	54656	7111	79682547
Off label use	128.39	12.10	1060	53670	906155	78783503
Total lung capacity increased	127.89	12.10	51	54679	2247	79687411
Asthma-chronic obstructive pulmonary disease overlap syndrome	117.62	12.10	53	54677	3168	79686490
Hepatotoxicity	117.45	12.10	160	54570	51192	79638466
Spirometry abnormal	116.79	12.10	38	54692	921	79688737
Corneal epithelium defect	114.66	12.10	35	54695	684	79688974
Uveitis	110.51	12.10	92	54638	16738	79672920
Vitritis	107.49	12.10	42	54688	1752	79687906
Iris hypopigmentation	107.04	12.10	21	54709	48	79689610
Loss of employment	105.50	12.10	46	54684	2541	79687117
Obliterative bronchiolitis	101.67	12.10	47	54683	2981	79686677
Corneal perforation	100.14	12.10	32	54698	731	79688927
Dust allergy	95.72	12.10	37	54693	1499	79688159
Oesophageal spasm	92.78	12.10	46	54684	3410	79686248
Mite allergy	92.51	12.10	34	54696	1196	79688462
Neuropathy peripheral	90.68	12.10	257	54473	141048	79548610
Pigment dispersion syndrome	89.48	12.10	16	54714	16	79689642
Iris atrophy	89.18	12.10	21	54709	141	79689517
Conjunctivitis allergic	88.23	12.10	36	54694	1684	79687974
Drug reaction with eosinophilia and systemic symptoms	87.87	12.10	158	54572	64086	79625572
Conjunctival hyperaemia	87.67	12.10	48	54682	4365	79685293
Nasal polyps	86.44	12.10	57	54673	7270	79682388
Mycotic allergy	85.53	12.10	34	54696	1485	79688173
Ototoxicity	83.24	12.10	42	54688	3232	79686426
Death	81.98	12.10	166	54564	566348	79123310
Iridocyclitis	81.17	12.10	43	54687	3661	79685997
Pathogen resistance	75.24	12.10	69	54661	14273	79675385
Tinnitus	75.16	12.10	120	54610	44213	79645445
Drug-induced liver injury	73.63	12.10	149	54581	65968	79623690
Sleep disorder due to a general medical condition	73.56	12.10	68	54662	14209	79675449
Toxicity to various agents	73.23	12.10	110	54620	421430	79268228
Oesophageal pain	72.69	12.10	42	54688	4237	79685421
Drug intolerance	71.35	12.10	364	54366	263755	79425903
Vitreous opacities	71.21	12.10	24	54706	651	79689007
Sarcoidosis	70.73	12.10	53	54677	8282	79681376
Vision blurred	69.28	12.10	194	54536	105704	79583954
Ocular hyperaemia	67.71	12.10	90	54640	28116	79661542
Tuberculoma of central nervous system	66.41	12.10	22	54708	565	79689093
Product dose omission issue	65.25	12.10	45	54685	247492	79442166
Torsade de pointes	64.84	12.10	73	54657	19239	79670419
Rhinitis allergic	64.31	12.10	59	54671	12210	79677448
Upper respiratory tract infection	62.59	12.10	170	54560	90998	79598660
Nasal oedema	61.78	12.10	28	54702	1696	79687962
Anaphylactic reaction	61.38	12.10	160	54570	83583	79606075
Corneal decompensation	60.62	12.10	13	54717	53	79689605
Temperature regulation disorder	60.61	12.10	42	54688	5811	79683847
Food allergy	60.57	12.10	54	54676	10770	79678888
Musculoskeletal injury	60.35	12.10	16	54714	183	79689475
Tendon pain	59.53	12.10	41	54689	5617	79684041
Anterior chamber disorder	58.68	12.10	15	54715	147	79689511
Sputum purulent	58.33	12.10	25	54705	1324	79688334
Persistent corneal epithelial defect	55.75	12.10	12	54718	50	79689608
Punctate keratitis	55.28	12.10	22	54708	964	79688694
Tendonitis	54.09	12.10	74	54656	23756	79665902
Eye inflammation	52.69	12.10	40	54690	6373	79683285
Nicotine dependence	52.47	12.10	21	54709	934	79688724
Retinal haemorrhage	52.05	12.10	44	54686	8173	79681485
Multiple-drug resistance	51.39	12.10	45	54685	8763	79680895
Infective keratitis	50.33	12.10	11	54719	50	79689608
Treatment failure	50.29	12.10	241	54489	170245	79519413
Cataract	50.02	12.10	123	54607	61997	79627661
Immune reconstitution inflammatory syndrome	49.36	12.10	54	54676	13787	79675871
Acinetobacter infection	49.16	12.10	28	54702	2749	79686909
Dehydration	48.90	12.10	59	54671	248128	79441530
Lymphoedema	48.80	12.10	51	54679	12362	79677296
Immunodeficiency	48.51	12.10	67	54663	21701	79667957
Bronchitis chronic	48.39	12.10	33	54697	4449	79685209
Full blood count abnormal	47.19	12.10	93	54637	40381	79649277
Psoriasis	46.23	12.10	151	54579	89436	79600222
Corneal disorder	45.74	12.10	25	54705	2266	79687392
Hypotension	45.26	12.10	153	54577	440164	79249494
Optic neuritis	44.57	12.10	43	54687	9477	79680181
Keratitis fungal	44.22	12.10	14	54716	310	79689348
Keratitis bacterial	44	12.10	12	54718	154	79689504
Cough	42.94	12.10	412	54318	366377	79323281
Photophobia	42.50	12.10	61	54669	20467	79669191
Hallucination	41.99	12.10	142	54588	85603	79604055
Cardiac murmur	41.89	12.10	53	54677	15771	79673887
Dysbiosis	41.17	12.10	19	54711	1200	79688458
Fibrin	40.56	12.10	8	54722	19	79689639
Corneal flap complication	39.67	12.10	7	54723	6	79689652
Productive cough	39.55	12.10	142	54588	88189	79601469
Necrotising scleritis	39.34	12.10	12	54718	234	79689424
Visual impairment	38.63	12.10	145	54585	91986	79597672
Fall	38.45	12.10	188	54542	487441	79202217
Corneal deposits	38.32	12.10	14	54716	484	79689174
Skin reaction	38.14	12.10	51	54679	16017	79673641
Rash erythematous	36.95	12.10	105	54625	57664	79631994
Alopecia	36.71	12.10	64	54666	231291	79458367
Coeliac disease	36.56	12.10	42	54688	11309	79678349
NPM1 gene mutation	36.55	12.10	10	54720	130	79689528
Corynebacterium infection	36.48	12.10	18	54712	1320	79688338
Foreign body sensation in eyes	36.18	12.10	21	54709	2136	79687522
Chest injury	35.86	12.10	23	54707	2798	79686860
Bronchiectasis	35.77	12.10	59	54671	22327	79667331
Corneal transplant	35.28	12.10	12	54718	335	79689323
Multiple fractures	35.23	12.10	35	54695	7991	79681667
Tendon discomfort	35.14	12.10	13	54717	466	79689192
Cerebrovascular accident	34.94	12.10	33	54697	155259	79534399
Acute kidney injury	34.50	12.10	212	54518	519192	79170466
Hyponatraemia	34.26	12.10	43	54687	177805	79511853
Forced expiratory volume decreased	34.16	12.10	34	54696	7780	79681878
Diastasis recti abdominis	34.06	12.10	7	54723	22	79689636
Disorganised speech	33.90	12.10	20	54710	2097	79687561
Keratitis	33.41	12.10	26	54704	4296	79685362
Hypomania	33.31	12.10	33	54697	7511	79682147
Systemic lupus erythematosus	33.28	12.10	21	54709	121128	79568530
Suicide attempt	33.24	12.10	8	54722	82924	79606734
Bradycardia	32.67	12.10	27	54703	135530	79554128
Blood immunoglobulin A decreased	32.21	12.10	17	54713	1436	79688222
Hepatic steatosis	31.74	12.10	76	54654	37662	79651996
Drug ineffective for unapproved indication	31.67	12.10	92	54638	51146	79638512
Painful respiration	31.65	12.10	23	54707	3430	79686228
Foetal death	31.53	12.10	33	54697	8011	79681647
Hyperkalaemia	31.19	12.10	20	54710	114378	79575280
Retinal detachment	31.12	12.10	35	54695	9212	79680446
Secondary immunodeficiency	30.69	12.10	22	54708	3212	79686446
Flat anterior chamber of eye	30.66	12.10	9	54721	153	79689505
Retinal vasculitis	30.48	12.10	16	54714	1337	79688321
Factor V deficiency	30.46	12.10	8	54722	88	79689570
Bronchitis	30.43	12.10	173	54557	130471	79559187
Deafness	30.37	12.10	53	54677	20984	79668674
Blood immunoglobulin M increased	30.33	12.10	16	54714	1350	79688308
Lung neoplasm malignant	30.18	12.10	62	54668	27730	79661928
Product use in unapproved indication	30.15	12.10	283	54447	250076	79439582
Hand deformity	29.97	12.10	17	54713	103902	79585756
Urethritis mycoplasmal	29.40	12.10	6	54724	18	79689640
Pneumonia	29.38	12.10	625	54105	659621	79030037
Pupillary disorder	29.35	12.10	12	54718	564	79689094
Atypical mycobacterial infection	29.32	12.10	17	54713	1726	79687932
Chimerism	29.17	12.10	10	54720	286	79689372
Aortic aneurysm	28.47	12.10	32	54698	8414	79681244
Glossodynia	28.27	12.10	18	54712	103319	79586339
Non-infectious endophthalmitis	28.07	12.10	10	54720	321	79689337
Bronchiolitis obliterans syndrome	27.84	12.10	10	54720	329	79689329
Cystoid macular oedema	27.31	12.10	17	54713	1963	79687695
Keratic precipitates	27.17	12.10	10	54720	353	79689305
Sputum discoloured	26.61	12.10	51	54679	21692	79667966
Urinary tract infection	26.42	12.10	98	54632	274414	79415244
Polyneuropathy	26.37	12.10	54	54676	24097	79665561
Pemphigus	26.35	12.10	18	54712	99564	79590094
Maternal exposure during pregnancy	26.30	12.10	33	54697	136505	79553153
Herpes zoster	26.28	12.10	130	54600	92953	79596705
Retinal ischaemia	25.74	12.10	12	54718	776	79688882
Normochromic normocytic anaemia	25.58	12.10	29	54701	7698	79681960
Stenotrophomonas infection	25.55	12.10	21	54709	3752	79685906
Injection site pain	25.41	12.10	31	54699	129807	79559851
Thalamic infarction	25.37	12.10	14	54716	1293	79688365
Chronic obstructive pulmonary disease	25.34	12.10	121	54609	85298	79604360
Detachment of retinal pigment epithelium	25.34	12.10	12	54718	804	79688854
Fatigue	25.27	12.10	468	54262	929259	78760399
Injection site erythema	25.25	12.10	11	54719	78186	79611472
Rash	25.23	12.10	546	54184	577812	79111846
Bronchial ulceration	25.14	12.10	4	54726	0	79689658
Aqueous humour leakage	25.14	12.10	4	54726	0	79689658
Neoplasm progression	25.07	12.10	3	54727	51679	79637979
Corneal scar	24.97	12.10	9	54721	299	79689359
Optic neuropathy	24.87	12.10	20	54710	3464	79686194
Tachyarrhythmia	24.54	12.10	27	54703	6935	79682723
Eye abscess	24.06	12.10	9	54721	333	79689325
Glaucoma	23.75	12.10	46	54684	19715	79669943
Bursitis	23.75	12.10	66	54664	35778	79653880
Peripheral nerve injury	23.71	12.10	11	54719	703	79688955
Anti-cyclic citrullinated peptide antibody positive	23.41	12.10	14	54716	83129	79606529
Acute myeloid leukaemia recurrent	23.26	12.10	19	54711	3364	79686294
Iris adhesions	23.22	12.10	10	54720	536	79689122
Skin injury	23.15	12.10	19	54711	3387	79686271
Blepharitis allergic	22.90	12.10	4	54726	3	79689655
Metamorphopsia	22.79	12.10	13	54717	1280	79688378
Anterior chamber inflammation	22.74	12.10	10	54720	564	79689094
Jaundice cholestatic	22.59	12.10	33	54697	11251	79678407
Hypoacusis	22.48	12.10	58	54672	30092	79659566
Wound	22.46	12.10	28	54702	116151	79573507
Psychotic disorder	22.45	12.10	71	54659	41331	79648327
Hyperhidrosis	22.27	12.10	179	54551	151313	79538345
Obstructive airways disorder	21.91	12.10	59	54671	31400	79658258
Chest discomfort	21.89	12.10	166	54564	137878	79551780
Respiratory moniliasis	21.83	12.10	8	54722	279	79689379
Eye oedema	21.82	12.10	15	54715	2048	79687610
Nosocomial infection	21.81	12.10	17	54713	2815	79686843
Choroidal detachment	21.75	12.10	10	54720	626	79689032
Vitreous haemorrhage	21.72	12.10	19	54711	3694	79685964
Cataract operation	21.64	12.10	22	54708	5163	79684495
Conjunctival oedema	21.37	12.10	12	54718	1146	79688512
Eye infection staphylococcal	21.31	12.10	7	54723	175	79689483
Dyspepsia	21.21	12.10	26	54704	108661	79580997
Acoustic neuroma	21.21	12.10	8	54722	303	79689355
Cardio-respiratory arrest	21.13	12.10	26	54704	108484	79581174
Sepsis	21.12	12.10	104	54626	269324	79420334
Stevens-Johnson syndrome	21.09	12.10	67	54663	39099	79650559
Blood immunoglobulin G increased	21.00	12.10	17	54713	2972	79686686
Corneal thinning	20.91	12.10	7	54723	186	79689472
Tuberculosis of central nervous system	20.87	12.10	9	54721	484	79689174
Tendon rupture	20.79	12.10	33	54697	12093	79677565
Fluid retention	20.79	12.10	99	54631	69710	79619948
Arthropathy	20.68	12.10	58	54672	177053	79512605
Discomfort	20.60	12.10	34	54696	125583	79564075
Cystitis	20.47	12.10	81	54649	52651	79637007
Respiratory arrest	20.40	12.10	7	54723	57543	79632115
Vitreous haze	20.38	12.10	6	54724	103	79689555
Malignant neoplasm progression	20.33	12.10	39	54691	135951	79553707
Pericarditis	20.28	12.10	25	54705	104211	79585447
Eye infection fungal	20.26	12.10	9	54721	520	79689138
Herpes zoster meningoencephalitis	20.04	12.10	10	54720	751	79688907
Coronary artery disease	19.92	12.10	10	54720	65464	79624194
Anterior chamber pigmentation	19.86	12.10	4	54726	11	79689647
Multiple sclerosis relapse	19.63	12.10	4	54726	46529	79643129
Blindness unilateral	19.56	12.10	26	54704	8120	79681538
Pruritus allergic	19.27	12.10	12	54718	1387	79688271
Haemostasis	19.21	12.10	8	54722	394	79689264
Immune reconstitution inflammatory syndrome associated tuberculosis	19.16	12.10	10	54720	826	79688832
Haematemesis	19.15	12.10	6	54724	52258	79637400
Scleromalacia	18.96	12.10	5	54725	56	79689602
General physical health deterioration	18.94	12.10	111	54619	275127	79414531
Eye discharge	18.89	12.10	22	54708	6012	79683646
Gonioscopy abnormal	18.86	12.10	3	54727	0	79689658
Mediastinal effusion	18.72	12.10	5	54725	59	79689599
Haematospermia	18.61	12.10	7	54723	263	79689395
Vaccination site haemorrhage	18.52	12.10	4	54726	17	79689641
Sleep apnoea syndrome	18.37	12.10	61	54669	36417	79653241
Cellulitis	18.37	12.10	29	54701	109031	79580627
Trichoglossia	18.37	12.10	9	54721	650	79689008
Multiple use of single-use product	18.22	12.10	10	54720	914	79688744
Myelosuppression	18.21	12.10	65	54665	40231	79649427
Retinal perivascular sheathing	18.20	12.10	5	54725	66	79689592
Pulmonary venous thrombosis	18.19	12.10	6	54724	152	79689506
Rheumatic disorder	18.15	12.10	16	54714	3142	79686516
Hypoglycaemia	18.10	12.10	26	54704	101568	79588090
Corneal neovascularisation	17.97	12.10	6	54724	158	79689500
Anterior chamber flare	17.93	12.10	6	54724	159	79689499
Caffeine allergy	17.82	12.10	4	54726	21	79689637
Tuberculosis	17.81	12.10	35	54695	15163	79674495
Thrombocytopenia	17.75	12.10	268	54462	264991	79424667
Vitreal cells	17.74	12.10	5	54725	73	79689585
Gastroenteritis staphylococcal	17.71	12.10	7	54723	301	79689357
Memory impairment	17.63	12.10	31	54699	111703	79577955
Gastric disorder	17.45	12.10	61	54669	37372	79652286
Headache	17.43	12.10	330	54400	653442	79036216
Mycobacterium chelonae infection	17.32	12.10	14	54716	2442	79687216
Injection site reaction	17.23	12.10	8	54722	54777	79634881
Lactic acidosis	16.97	12.10	14	54716	70345	79619313
Vomiting	16.86	12.10	586	54144	665242	79024416
Rhabdomyolysis	16.83	12.10	28	54702	103103	79586555
Phosphorus metabolism disorder	16.78	12.10	3	54727	3	79689655
Implant site hypersensitivity	16.72	12.10	4	54726	29	79689629
Vanishing bile duct syndrome	16.65	12.10	12	54718	1766	79687892
Eyelid oedema	16.62	12.10	32	54698	13655	79676003
Nocardiosis	16.61	12.10	20	54710	5659	79683999
Vitreous degeneration	16.60	12.10	4	54726	30	79689628
Forced vital capacity abnormal	16.60	12.10	4	54726	30	79689628
Lacrimation increased	16.51	12.10	43	54687	22434	79667224
Increased viscosity of bronchial secretion	16.48	12.10	8	54722	566	79689092
Biopsy colon abnormal	16.46	12.10	5	54725	96	79689562
Morganella infection	16.37	12.10	10	54720	1117	79688541
Disseminated mycobacterium avium complex infection	16.33	12.10	6	54724	211	79689447
Corneal erosion	16.29	12.10	7	54723	373	79689285
Overdose	16.29	12.10	68	54662	184138	79505520
Injection site swelling	16.25	12.10	6	54724	47126	79642532
Schizophrenia	16.24	12.10	34	54696	15406	79674252
Masticatory pain	16.16	12.10	4	54726	34	79689624
FEV1/FVC ratio abnormal	16.06	12.10	4	54726	35	79689623
Product use issue	16.04	12.10	217	54513	209605	79480053
Contraindicated product administered	16.01	12.10	172	54558	157366	79532292
Sitting disability	16.00	12.10	7	54723	390	79689268
Muscle spasms	15.76	12.10	64	54666	174666	79514992
Vitreous floaters	15.67	12.10	22	54708	7234	79682424
Retinal artery occlusion	15.65	12.10	15	54715	3279	79686379
Eye irritation	15.64	12.10	40	54690	20641	79669017
Acute myocardial infarction	15.49	12.10	18	54712	77018	79612640
Nervous system disorder	15.44	12.10	47	54683	26809	79662849
Anaemia	15.38	12.10	214	54516	444801	79244857
Rash morbilliform	15.34	12.10	20	54710	6130	79683528
Hypotony of eye	15.32	12.10	6	54724	252	79689406
Idiopathic orbital inflammation	15.25	12.10	6	54724	255	79689403
Scleral thinning	15.23	12.10	4	54726	44	79689614
Upper respiratory tract irritation	15.20	12.10	6	54724	257	79689401
Hyperalbuminaemia	15.15	12.10	4	54726	45	79689613
Benign soft tissue neoplasm	15.15	12.10	5	54725	127	79689531
Axonal neuropathy	15.11	12.10	12	54718	2042	79687616
Cardiogenic shock	15.02	12.10	5	54725	41909	79647749
Deafness neurosensory	15.02	12.10	21	54709	6877	79682781
Dyspnoea	14.98	12.10	725	54005	856300	78833358
Allergic cough	14.95	12.10	8	54722	695	79688963
Aqueous fibrin	14.93	12.10	5	54725	133	79689525
Visual acuity reduced transiently	14.92	12.10	6	54724	270	79689388
Nerve block	14.84	12.10	8	54722	705	79688953
Choroidal neovascularisation	14.81	12.10	7	54723	467	79689191
Mycobacterium avium complex infection	14.78	12.10	17	54713	4583	79685075
Enterococcal infection	14.77	12.10	33	54697	15627	79674031
Eye pruritus	14.75	12.10	39	54691	20531	79669127
Macular fibrosis	14.74	12.10	8	54722	715	79688943
Erythema of eyelid	14.73	12.10	13	54717	2557	79687101
Transient ischaemic attack	14.65	12.10	9	54721	52686	79636972
Toxic epidermal necrolysis	14.59	12.10	65	54665	44516	79645142
Swelling	14.58	12.10	88	54642	216623	79473035
Weight increased	14.58	12.10	121	54609	277265	79412393
Anaphylactic shock	14.54	12.10	56	54674	35940	79653718
Incorrect product administration duration	14.47	12.10	28	54702	11994	79677664
Cutis laxa	14.45	12.10	5	54725	147	79689511
Paraneoplastic syndrome	14.45	12.10	9	54721	1041	79688617
Complications of transplant surgery	14.39	12.10	8	54722	749	79688909
Dysmetria	14.28	12.10	9	54721	1062	79688596
AIDS related complication	14.22	12.10	4	54726	58	79689600
Therapeutic response decreased	14.12	12.10	15	54715	66838	79622820
Rectal haemorrhage	14.11	12.10	19	54711	76281	79613377
Drug ineffective	14.10	12.10	890	53840	1080023	78609635
Language disorder	14.08	12.10	14	54716	3200	79686458
Eosinophilic pneumonia acute	14.08	12.10	9	54721	1089	79688569
Breast conserving surgery	14.08	12.10	8	54722	782	79688876
Chondritis	14.05	12.10	5	54725	160	79689498
Sinus pain	14.04	12.10	15	54715	3727	79685931
Neurilemmoma benign	14.04	12.10	3	54727	12	79689646
Musculoskeletal stiffness	14.03	12.10	67	54663	174941	79514717
Hypersensitivity	13.88	12.10	255	54475	261984	79427674
Orthostatic hypotension	13.76	12.10	11	54719	56153	79633505
Prostate cancer	13.75	12.10	3	54727	33265	79656393
Anterior chamber fibrin	13.74	12.10	5	54725	171	79689487
Back pain	13.69	12.10	138	54592	304042	79385616
Toxic optic neuropathy	13.67	12.10	9	54721	1144	79688514
Incision site pain	13.66	12.10	13	54717	2817	79686841
Ocular hypertension	13.65	12.10	10	54720	1510	79688148
Dysdiadochokinesis	13.60	12.10	6	54724	341	79689317
Product monitoring error	13.59	12.10	23	54707	8883	79680775
Injection site pruritus	13.57	12.10	6	54724	42277	79647381
COVID-19	13.45	12.10	59	54671	157615	79532043
Suspected counterfeit product	13.40	12.10	7	54723	579	79689079
Keratopathy	13.39	12.10	9	54721	1185	79688473
Allergic sinusitis	13.38	12.10	8	54722	859	79688799
Circumstance or information capable of leading to medication error	13.38	12.10	15	54715	3933	79685725
Lethargy	13.33	12.10	22	54708	81270	79608388
Helicobacter infection	13.26	12.10	17	54713	69687	79619971
Vestibular disorder	13.24	12.10	12	54718	2443	79687215
Mycobacterium abscessus infection	13.20	12.10	9	54721	1213	79688445
Hepatic enzyme increased	13.20	12.10	187	54543	182423	79507235
Urticaria	13.12	12.10	189	54541	185012	79504646
Rheumatoid factor positive	13.12	12.10	13	54717	59826	79629832
Contusion	13.10	12.10	55	54675	148721	79540937
Respiratory tract infection	13.04	12.10	67	54663	48622	79641036
Nodule	12.99	12.10	40	54690	22954	79666704
Type IV hypersensitivity reaction	12.97	12.10	15	54715	4066	79685592
Tendon disorder	12.93	12.10	20	54710	7166	79682492
Scleral disorder	12.81	12.10	5	54725	208	79689450
Limb mass	12.76	12.10	14	54716	3585	79686073
Corneal striae	12.76	12.10	3	54727	20	79689638
Duodenal ulcer perforation	12.75	12.10	16	54714	66195	79623463
Somnolence	12.67	12.10	104	54626	238877	79450781
Atypical mycobacterium test positive	12.63	12.10	3	54727	21	79689637
Skin odour abnormal	12.61	12.10	11	54719	2130	79687528
Red blood cell count increased	12.60	12.10	15	54715	4193	79685465
Retinal oedema	12.60	12.10	8	54722	957	79688701
Osteonecrosis of jaw	12.56	12.10	7	54723	43219	79646439
Legionella test positive	12.51	12.10	3	54727	22	79689636
Intracardiac mass	12.42	12.10	5	54725	226	79689432
Ocular icterus	12.36	12.10	17	54713	5483	79684175
Hip fracture	12.26	12.10	3	54727	30758	79658900

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	J01MA14	ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE QUINOLONE ANTIBACTERIALS Fluoroquinolones
ATC	S01AE07	SENSORY ORGANS OPHTHALMOLOGICALS ANTIINFECTIVES Fluoroquinolones
FDA CS	M0023650	Quinolones
FDA CS	M0372253	Fluoroquinolones
MeSH PA	D000900	Anti-Bacterial Agents
MeSH PA	D000890	Anti-Infective Agents
MeSH PA	D000970	Antineoplastic Agents
MeSH PA	D004791	Enzyme Inhibitors
MeSH PA	D059005	Topoisomerase II Inhibitors
MeSH PA	D059003	Topoisomerase Inhibitors
CHEBI has role	CHEBI:36047	antibacterial drugs
FDA EPC	N0000175937	Quinolone Antimicrobial
FDA EPC	N0000193223	Fluoroquinolone Antibacterial

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Septicemic plague	indication	9012003	DOID:3481
Infection of skin AND/OR subcutaneous tissue	indication	19824006
Staphylococcal pneumonia	indication	22754005
Pneumonia due to Streptococcus	indication	34020007
Pneumonic plague	indication	38976008	DOID:10398
Pneumonia due to Mycoplasma pneumoniae	indication	46970008
Peritonitis	indication	48661000
Bacterial pneumonia	indication	53084003	DOID:874
Pneumonia due to Klebsiella pneumoniae	indication	64479007
Haemophilus influenzae pneumonia	indication	70036007
Rhinoscleroma	indication	72409005	DOID:11336
Abdominal abscess	indication	75100008
Acute bacterial sinusitis	indication	75498004
Infectious disease of abdomen	indication	128070006
Bacterial conjunctivitis	indication	128350005	DOID:9700
Infection due to Enterobacteriaceae	indication	128945009
Bacterial infection due to Klebsiella pneumoniae	indication	186435004
Pneumococcal pneumonia	indication	233607000
Chlamydial pneumonia	indication	233609002
Streptococcus pyogenes infection	indication	302809008
Infection due to Staphylococcus aureus	indication	406602003
Acute exacerbation of chronic bronchitis	indication	425748003
Complicated Skin and Skin Structure E. Coli Infection	indication
Complicated Skin and Skin Structure Infection	indication
Haemophilus Influenzae Chronic Bronchitis	indication
Complicated Skin and Skin Structure Staphylococcus Aureus Infection	indication
Haemophilus Parainfluenzae Chronic Bronchitis	indication
Streptococcus Pneumoniae Chronic Bronchitis	indication
Moraxella Catarrhalis Pneumonia	indication
Staphylococcus Chronic Bronchitis	indication
Klebsiella Pneumoniae Chronic Bronchitis	indication
Moraxella Catarrhalis Chronic Bronchitis	indication
Acute tuberculosis	off-label use	25629007
Pulmonary tuberculosis	off-label use	154283005	DOID:2957
Cirrhosis of liver	contraindication	19943007	DOID:5082
Torsades de pointes	contraindication	31722008
Transplantation of heart	contraindication	32413006
Tendinitis	contraindication	34840004	DOID:971
Hypokalemia	contraindication	43339004
Conduction disorder of the heart	contraindication	44808001
Bradycardia	contraindication	48867003
Transplant of kidney	contraindication	70536003
Epilepsy	contraindication	84757009	DOID:1826
Transplant of lung	contraindication	88039007
Myasthenia gravis	contraindication	91637004	DOID:437
Prolonged QT interval	contraindication	111975006
Liver function tests abnormal	contraindication	166603001
Drug-induced hepatitis	contraindication	235876009
Peripheral nerve disease	contraindication	302226006
Pseudomembranous enterocolitis	contraindication	397683000
Myocardial ischemia	contraindication	414795007	DOID:3393
Traumatic rupture of tendon	contraindication	415749005
Congenital long QT syndrome	contraindication	442917000
Severe Cerebral Arteriosclerosis	contraindication

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	6.23	acidic
pKa2	8.54	Basic
pKa3	2.92	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Topoisomerase IV	Enzyme		PARC_ECOLI PARE_ECOLI	INHIBITOR				CHEMBL	CHEMBL
DNA gyrase	Enzyme		GYRA_ECOLI GYRB_ECOLI	INHIBITOR	IC50	6.52		CHEMBL	CHEMBL
DNA topoisomerase 4 subunit A	Enzyme		PARC_STAAU		IC50	6.10		CHEMBL
DNA gyrase subunit A	Enzyme		GYRA_MYCTU		IC50	5.04		CHEMBL

External reference:

ID	Source
D00874	KEGG_DRUG
186826-86-8	SECONDARY_CAS_RN
4021185	VANDF
4021186	VANDF
C0536495	UMLSCUI
CHEBI:63611	CHEBI
MFX	PDB_CHEM_ID
CHEMBL32	ChEMBL_ID
CHEMBL1200735	ChEMBL_ID
D000077266	MESH_DESCRIPTOR_UI
DB00218	DRUGBANK_ID
152946	PUBCHEM_CID
10915	IUPHAR_LIGAND_ID
7659	INN_ID
U188XYD42P	UNII
1047505	RXNORM
178916	MMSL
213098	MMSL
31558	MMSL
35332	MMSL
359581	MMSL
359583	MMSL
40847	MMSL
8580	MMSL
d04500	MMSL
007927	NDDF
007928	NDDF
116347002	SNOMEDCT_US
371296007	SNOMEDCT_US
412439003	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
MOXEZA	HUMAN PRESCRIPTION DRUG LABEL	1	0065-0006	SOLUTION	5 mg	OPHTHALMIC	NDA	23 sections
VIGAMOX	HUMAN PRESCRIPTION DRUG LABEL	1	0065-4013	SOLUTION/ DROPS	5 mg	OPHTHALMIC	NDA	25 sections
VIGAMOX	HUMAN PRESCRIPTION DRUG LABEL	1	0065-4013	SOLUTION/ DROPS	5 mg	OPHTHALMIC	NDA	25 sections
VIGAMOX	HUMAN PRESCRIPTION DRUG LABEL	1	0078-0939	SOLUTION/ DROPS	5 mg	OPHTHALMIC	NDA	25 sections
VIGAMOX	HUMAN PRESCRIPTION DRUG LABEL	1	0078-0939	SOLUTION/ DROPS	5 mg	OPHTHALMIC	NDA	25 sections
VIGAMOX	HUMAN PRESCRIPTION DRUG LABEL	1	0078-0939	SOLUTION/ DROPS	5 mg	OPHTHALMIC	NDA	25 sections
Moxifloxacin Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0093-7387	TABLET, FILM COATED	400 mg	ORAL	ANDA	28 sections
Moxifloxacin Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0093-7387	TABLET, FILM COATED	400 mg	ORAL	ANDA	28 sections
Moxifloxacin	HUMAN PRESCRIPTION DRUG LABEL	1	0378-5430	SOLUTION/ DROPS	5 mg	OPHTHALMIC	ANDA	24 sections
Moxifloxacin	HUMAN PRESCRIPTION DRUG LABEL	1	0378-5430	SOLUTION/ DROPS	5 mg	OPHTHALMIC	ANDA	24 sections
Moxifloxacin Ophthalmic Solution	HUMAN PRESCRIPTION DRUG LABEL	1	0781-7135	SOLUTION/ DROPS	5 mg	OPHTHALMIC	NDA authorized generic	25 sections
Moxifloxacin Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0832-1410	SOLUTION	5 mg	OPHTHALMIC	ANDA	26 sections
Moxifloxacin Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0832-1410	SOLUTION	5 mg	OPHTHALMIC	ANDA	26 sections
Moxifloxacin	HUMAN PRESCRIPTION DRUG LABEL	1	0904-6406	TABLET, FILM COATED	400 mg	ORAL	ANDA	30 sections
Moxifloxacin	HUMAN PRESCRIPTION DRUG LABEL	1	0904-6406	TABLET, FILM COATED	400 mg	ORAL	ANDA	30 sections
moxifloxacin hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	13668-201	TABLET	400 mg	ORAL	ANDA	29 sections
moxifloxacin hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	13668-201	TABLET	400 mg	ORAL	ANDA	29 sections
moxifloxacin hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	13668-201	TABLET	400 mg	ORAL	ANDA	29 sections
Avelox ABC Pack	HUMAN PRESCRIPTION DRUG LABEL	1	16590-881	TABLET, FILM COATED	400 mg	ORAL	NDA	17 sections
MOXIFLOXACIN	Human Prescription Drug Label	1	16714-643	SOLUTION/ DROPS	5 mg	OPHTHALMIC	ANDA	23 sections
MOXIFLOXACIN	Human Prescription Drug Label	1	16714-643	SOLUTION/ DROPS	5 mg	OPHTHALMIC	ANDA	23 sections
Moxifloxacin	HUMAN PRESCRIPTION DRUG LABEL	1	17478-519	SOLUTION/ DROPS	5 mg	OPHTHALMIC	ANDA	25 sections
VIGAMOX	HUMAN PRESCRIPTION DRUG LABEL	1	21695-968	SOLUTION	5 mg	OPHTHALMIC	NDA	20 sections
Moxifloxacin	HUMAN PRESCRIPTION DRUG LABEL	1	31722-845	TABLET, FILM COATED	400 mg	ORAL	ANDA	28 sections
Moxifloxacin Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	40032-034	TABLET	400 mg	ORAL	ANDA	28 sections
Moxifloxacin	HUMAN PRESCRIPTION DRUG LABEL	1	50090-3147	TABLET, FILM COATED	400 mg	ORAL	ANDA	30 sections
Moxifloxacin	HUMAN PRESCRIPTION DRUG LABEL	1	50090-3147	TABLET, FILM COATED	400 mg	ORAL	ANDA	30 sections
Moxifloxacin Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	50090-4058	TABLET	400 mg	ORAL	ANDA	32 sections
Moxifloxacin Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	50090-4058	TABLET	400 mg	ORAL	ANDA	32 sections
Moxifloxacin Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	50090-4100	TABLET	400 mg	ORAL	ANDA	32 sections