All FDA-approved EMA-approved PMDA-approved
Target Card Uniprot Example: P23975

moxifloxacin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
antibacterials, nalidixic acid derivatives	1854	151096-09-2

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: avelox moxifloxacin moxifloxacin hydrochloride avolex moxeza moxifloxacine moxifloxacin HCl	A fluoroquinolone that acts as an inhibitor of DNA TOPOISOMERASE II and is used as a broad-spectrum antibacterial agent. Molecular weight: 401.44 Formula: C21H24FN3O4 CLOGP: -0.12 LIPINSKI: 0 HAC: 7 HDO: 2 TPSA: 82.11 ALOGS: -3.38 ROTB: 4 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Drug dosage:

Dose	Unit	Route
0.40	g	O
0.40	g	P

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	3	Benet LZ, Broccatelli F, Oprea TI
S (Water solubility)	27.50 mg/mL	Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine)	22 %	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	14.23 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability)	86 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution)	1.40 L/kg	Lombardo F, Berellini G, Obach RS
CL (Clearance)	2.40 mL/min/kg	Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)	0.60 %	Lombardo F, Berellini G, Obach RS
t_half (Half-life)	8.20 hours	Lombardo F, Berellini G, Obach RS

Approvals:

Date	Agency	Company	Orphan
Dec. 10, 1999	FDA	BAYER HLTHCARE

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Drug hypersensitivity	315.38	13.37	508	25821	250502	50328293
Contrast media allergy	306.96	13.37	89	26240	1938	50576857
Toxic anterior segment syndrome	269.68	13.37	76	26253	1489	50577306
Iris transillumination defect	264.65	13.37	45	26284	44	50578751
Corneal oedema	171.20	13.37	52	26277	1335	50577460
Endophthalmitis	169.63	13.37	62	26267	2854	50575941
Hypopyon	150.15	13.37	40	26289	629	50578166
Electrocardiogram QT prolonged	148.50	13.37	158	26171	51728	50527067
Torsade de pointes	133.98	13.37	81	26248	11754	50567041
Obliterative bronchiolitis	128.95	13.37	45	26284	1808	50576987
Drug resistance	127.78	13.37	94	26235	18895	50559900
Corneal infiltrates	106.38	13.37	22	26307	102	50578693
Visual acuity reduced	105.62	13.37	86	26243	20053	50558742
Corneal epithelium defect	89.48	13.37	23	26306	312	50578483
Upper respiratory tract infection	88.66	13.37	138	26191	65760	50513035
Eye pain	87.37	13.37	90	26239	28359	50550436
Corneal opacity	87.09	13.37	26	26303	628	50578167
Musculoskeletal injury	83.43	13.37	18	26311	106	50578689
Asthma-chronic obstructive pulmonary disease overlap syndrome	81.52	13.37	23	26306	452	50578343
Pigment dispersion syndrome	78.74	13.37	12	26317	0	50578795
Loss of employment	71.52	13.37	28	26301	1558	50577237
Drug intolerance	70.45	13.37	262	26067	218842	50359953
Drug reaction with eosinophilia and systemic symptoms	66.57	13.37	78	26251	28346	50550449
Nicotine dependence	65.89	13.37	21	26308	634	50578161
Psoriasis	65.75	13.37	124	26205	68876	50509919
Sputum purulent	65.52	13.37	23	26306	940	50577855
Ulcerative keratitis	64.26	13.37	29	26300	2304	50576491
Total lung capacity increased	63.74	13.37	21	26308	706	50578089
Vitritis	63.61	13.37	22	26307	860	50577935
Neuropathy peripheral	62.13	13.37	148	26181	96609	50482186
Ocular hyperaemia	61.94	13.37	64	26265	20228	50558567
Mental disorder	61.16	13.37	66	26263	21925	50556870
Asthma	59.91	13.37	139	26190	89198	50489597
Anaphylactic reaction	58.94	13.37	103	26226	53952	50524843
Paradoxical drug reaction	57.51	13.37	31	26298	3616	50575179
Acinetobacter infection	56.72	13.37	23	26306	1404	50577391
Oesophageal spasm	55.29	13.37	26	26303	2270	50576525
Secondary immunodeficiency	53.66	13.37	21	26308	1167	50577628
Nasal polyps	52.66	13.37	26	26303	2528	50576267
Hepatic steatosis	52.31	13.37	64	26265	24320	50554475
Systemic lupus erythematosus	52.24	13.37	6	26323	140616	50438179
Tuberculoma of central nervous system	52.09	13.37	15	26314	318	50578477
Pemphigus	50.48	13.37	3	26326	120163	50458632
Anterior chamber cell	50.36	13.37	16	26313	478	50578317
Arthropathy	49.13	13.37	11	26318	157895	50420900
Vision blurred	49.07	13.37	119	26210	78528	50500267
Punctate keratitis	48.47	13.37	16	26313	541	50578254
Conjunctival hyperaemia	48.37	13.37	23	26306	2059	50576736
Glossodynia	48.20	13.37	3	26326	115566	50463229
Lymphoedema	47.91	13.37	39	26290	9083	50569712
Herpes zoster	47.29	13.37	110	26219	70676	50508119
Corneal perforation	46.62	13.37	15	26314	467	50578328
Oesophageal pain	44.69	13.37	24	26305	2778	50576017
Synovitis	44.27	13.37	6	26323	123859	50454936
Corneal disorder	44.11	13.37	20	26309	1606	50577189
Wheezing	42.08	13.37	97	26232	61950	50516845
Photophobia	41.95	13.37	45	26284	14842	50563953
Thrombocytopenia	41.22	13.37	153	26176	127520	50451275
Eye pruritus	40.92	13.37	41	26288	12493	50566302
Alopecia	39.00	13.37	42	26287	245005	50333790
Anterior chamber disorder	38.58	13.37	9	26320	79	50578716
Dysbiosis	38.26	13.37	14	26315	646	50578149
Tinnitus	37.92	13.37	59	26270	28073	50550722
Hand deformity	37.91	13.37	4	26325	100195	50478600
Bronchitis chronic	37.46	13.37	24	26305	3853	50574942
Stenotrophomonas infection	37.44	13.37	18	26311	1651	50577144
Toxic epidermal necrolysis	37.01	13.37	50	26279	20942	50557853
Off label use	36.56	13.37	392	25937	474034	50104761
Intraocular pressure increased	36.40	13.37	27	26302	5489	50573306
Iris atrophy	36.40	13.37	8	26321	52	50578743
Retinal haemorrhage	36.15	13.37	25	26304	4556	50574239
Tendonitis	36.08	13.37	44	26285	16661	50562134
Skin injury	35.38	13.37	17	26312	1557	50577238
Dysphoria	35.22	13.37	25	26304	4749	50574046
Factor V deficiency	33.92	13.37	8	26321	74	50578721
Forced expiratory volume decreased	32.39	13.37	23	26306	4371	50574424
Product dose omission issue	32.12	13.37	29	26300	183809	50394986
Cough	32.02	13.37	225	26104	241039	50337756
Ventricular tachycardia	31.49	13.37	40	26289	15781	50563014
Vanishing bile duct syndrome	31.41	13.37	12	26317	625	50578170
Food allergy	31.05	13.37	29	26300	8108	50570687
Skin reaction	30.91	13.37	34	26295	11534	50567261
Foreign body sensation in eyes	30.26	13.37	16	26313	1795	50577000
Tendon pain	30.18	13.37	19	26310	2959	50575836
Cataract	29.95	13.37	72	26257	47228	50531567
Non-infectious endophthalmitis	29.39	13.37	8	26321	137	50578658
Maternal exposure during pregnancy	29.38	13.37	24	26305	159754	50419041
Gastroenteritis staphylococcal	29.18	13.37	7	26322	70	50578725
Eye irritation	28.97	13.37	40	26289	17100	50561695
Full blood count abnormal	28.70	13.37	47	26282	23341	50555454
Drug-induced liver injury	28.63	13.37	52	26277	28043	50550752
Ototoxicity	27.87	13.37	13	26316	1114	50577681
Anterior chamber inflammation	27.86	13.37	9	26320	284	50578511
Embolism venous	27.84	13.37	17	26312	2508	50576287
Eosinophilic pneumonia acute	27.36	13.37	9	26320	301	50578494
Delirium	27.32	13.37	61	26268	38131	50540664
Pathogen resistance	27.13	13.37	23	26306	5666	50573129
Deafness	27.09	13.37	37	26292	15654	50563141
Eye infection staphylococcal	26.79	13.37	6	26323	43	50578752
Allergy to metals	26.43	13.37	10	26319	507	50578288
Iris hypopigmentation	26.25	13.37	4	26325	0	50578795
Corneal flap complication	26.25	13.37	4	26325	0	50578795
Stevens-Johnson syndrome	25.74	13.37	43	26286	21709	50557086
Sarcoidosis	25.40	13.37	21	26308	4996	50573799
Sputum discoloured	25.30	13.37	33	26296	13362	50565433
Corneal erosion	25.24	13.37	8	26321	237	50578558
Morganella infection	25.23	13.37	10	26319	575	50578220
Haemostasis	25.18	13.37	8	26321	239	50578556
Vitreous opacities	24.96	13.37	8	26321	246	50578549
Wound	24.80	13.37	12	26317	105782	50473013
Increased viscosity of bronchial secretion	24.75	13.37	8	26321	253	50578542
Eye inflammation	24.25	13.37	19	26310	4189	50574606
Obstructive airways disorder	24.19	13.37	35	26294	15617	50563178
Rash erythematous	24.19	13.37	55	26274	34797	50543998
Nosocomial infection	24.17	13.37	13	26316	1509	50577286
Fibrin	24.01	13.37	4	26325	3	50578792
Fall	23.62	13.37	92	26237	334840	50243955
Hepatotoxicity	23.56	13.37	47	26282	27179	50551616
Iodine allergy	23.48	13.37	10	26319	691	50578104
Nervous system disorder	23.23	13.37	35	26294	16188	50562607
Retinal ischaemia	23.02	13.37	8	26321	317	50578478
Infective keratitis	22.69	13.37	5	26324	33	50578762
Paraneoplastic syndrome	22.60	13.37	9	26320	524	50578271
Persistent corneal epithelial defect	22.59	13.37	4	26325	6	50578789
Rhinitis allergic	22.49	13.37	23	26306	7177	50571618
Dehydration	22.21	13.37	28	26301	152421	50426374
Condition aggravated	21.98	13.37	80	26249	296978	50281817
Corneal abscess	21.96	13.37	5	26324	39	50578756
Injection site erythema	21.78	13.37	6	26323	74930	50503865
Treatment failure	21.65	13.37	134	26195	137503	50441292
Pericarditis	21.60	13.37	7	26322	78682	50500113
Rash	21.53	13.37	333	25996	437138	50141657
Peripheral nerve injury	21.36	13.37	8	26321	394	50578401
Cryptococcosis	21.21	13.37	10	26319	878	50577917
Toxicity to various agents	20.95	13.37	50	26279	212449	50366346
Trichophytosis	20.58	13.37	5	26324	53	50578742
Mediastinal effusion	20.58	13.37	5	26324	53	50578742
Vitreous floaters	20.39	13.37	19	26310	5295	50573500
Optic neuropathy	20.22	13.37	12	26317	1682	50577113
Gastric disorder	19.81	13.37	46	26283	29502	50549293
Gonioscopy abnormal	19.69	13.37	3	26326	0	50578795
Bronchial ulceration	19.69	13.37	3	26326	0	50578795
Sinus pain	19.41	13.37	13	26316	2248	50576547
Gait disturbance	19.41	13.37	30	26299	149975	50428820
Forced vital capacity abnormal	19.09	13.37	4	26325	20	50578775
Skin odour abnormal	19.08	13.37	11	26318	1461	50577334
Caffeine allergy	18.93	13.37	4	26325	21	50578774
Bronchiectasis	18.90	13.37	25	26304	10258	50568537
Type I hypersensitivity	18.78	13.37	13	26316	2372	50576423
Retinal vasculitis	18.68	13.37	9	26320	829	50577966
Respiratory moniliasis	18.61	13.37	6	26323	188	50578607
Polyneuropathy	18.56	13.37	27	26302	12104	50566691
Back pain	18.50	13.37	56	26273	219974	50358821
Implant site hypersensitivity	18.48	13.37	4	26325	24	50578771
Swelling	18.45	13.37	49	26280	200823	50377972
Pupillary disorder	18.40	13.37	6	26323	195	50578600
Peripheral swelling	18.35	13.37	51	26278	205885	50372910
Hypertransaminasaemia	18.04	13.37	15	26314	3596	50575199
Bronchopulmonary aspergillosis	18.04	13.37	21	26308	7571	50571224
Enterococcal infection	17.95	13.37	20	26309	6878	50571917
Keratitis fungal	17.93	13.37	5	26324	94	50578701
Discomfort	17.86	13.37	18	26311	108362	50470433
Macular cyst	17.82	13.37	4	26325	29	50578766
Death	17.82	13.37	98	26231	325281	50253514
Chest discomfort	17.66	13.37	95	26234	92627	50486168
Fatigue	17.60	13.37	261	26068	707340	49871455
Hyperalbuminaemia	17.37	13.37	4	26325	33	50578762
Visual impairment	17.36	13.37	76	26253	68199	50510596
Vomiting	17.34	13.37	336	25993	460422	50118373
Biopsy colon abnormal	17.23	13.37	5	26324	109	50578686
Corneal neovascularisation	17.23	13.37	5	26324	109	50578686
Eye discharge	17.17	13.37	17	26312	5106	50573689
Rubber sensitivity	16.99	13.37	11	26318	1798	50576997
Rash morbilliform	16.73	13.37	13	26316	2833	50575962
Myelosuppression	16.36	13.37	27	26302	13490	50565305
Musculoskeletal stiffness	16.33	13.37	26	26303	128455	50450340
Pneumonia haemophilus	15.97	13.37	7	26322	519	50578276
Sleep apnoea syndrome	15.83	13.37	37	26292	23831	50554964
Iridocyclitis	15.74	13.37	11	26318	2038	50576757
Tendon rupture	15.72	13.37	19	26310	7125	50571670
Pain in extremity	15.59	13.37	81	26248	272784	50306011
Anterior chamber fibrin	15.58	13.37	4	26325	54	50578741
Wound haemorrhage	15.55	13.37	11	26318	2079	50576716
Lacrimation increased	15.50	13.37	30	26299	16962	50561833
Blister	15.48	13.37	13	26316	85405	50493390
Red blood cell count increased	15.42	13.37	12	26317	2619	50576176
Limb mass	15.25	13.37	12	26317	2663	50576132
Cardiac murmur	15.07	13.37	23	26306	10761	50568034
Detachment of retinal pigment epithelium	15.04	13.37	6	26323	351	50578444
Ventricular hypokinesia	14.83	13.37	14	26315	3966	50574829
Gastrointestinal mucosa hyperaemia	14.77	13.37	5	26324	183	50578612
Metamorphopsia	14.60	13.37	8	26321	963	50577832
Hypertension	14.58	13.37	171	26158	211032	50367763
Productive cough	14.43	13.37	60	26269	52634	50526161
Corneal deposits	14.30	13.37	5	26324	202	50578593
Anaphylactic shock	14.20	13.37	32	26297	20123	50558672
Malignant neoplasm progression	14.12	13.37	9	26320	68115	50510680
Retinal artery occlusion	13.86	13.37	9	26320	1478	50577317
Type IV hypersensitivity reaction	13.86	13.37	11	26318	2471	50576324
Hydrothorax	13.77	13.37	7	26322	724	50578071
Enterocolitis	13.70	13.37	17	26312	6550	50572245
Muscle spasms	13.63	13.37	28	26301	125525	50453270
Eosinophilia	13.57	13.37	30	26299	18622	50560173
Suicide attempt	13.51	13.37	5	26324	51727	50527068
Allergic cough	13.43	13.37	6	26323	465	50578330
Hyperhidrosis	13.39	13.37	86	26243	89340	50489455

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Visual acuity reduced	221.95	14.01	129	18052	14747	29541599
Eye pain	179.46	14.01	103	18078	11492	29544854
Choroiditis	166.80	14.01	49	18132	939	29555407
Intraocular pressure increased	161.25	14.01	72	18109	4717	29551629
Iris transillumination defect	157.06	14.01	25	18156	3	29556343
Endophthalmitis	150.37	14.01	59	18122	2789	29553557
Toxic anterior segment syndrome	147.29	14.01	45	18136	991	29555355
Delirium	144.53	14.01	148	18033	39249	29517097
Electrocardiogram QT prolonged	144.03	14.01	142	18039	35995	29520351
Uveitis	131.63	14.01	67	18114	5880	29550466
Corneal oedema	130.59	14.01	42	18139	1100	29555246
Drug resistance	119.70	14.01	102	18079	21438	29534908
Mental disorder	101.54	14.01	75	18106	12830	29543516
Ulcerative keratitis	95.03	14.01	35	18146	1388	29554958
Hypopyon	94.69	14.01	25	18156	317	29556029
Off label use	92.49	14.01	397	17784	300403	29255943
Dysphoria	85.27	14.01	36	18145	2056	29554290
Anterior chamber cell	74.59	14.01	20	18161	270	29556076
Hepatotoxicity	74.46	14.01	72	18109	17795	29538551
Neuropathy peripheral	74.19	14.01	146	18035	70881	29485465
Paradoxical drug reaction	72.89	14.01	35	18146	2706	29553640
Retinal haemorrhage	72.31	14.01	41	18140	4463	29551883
Corneal infiltrates	72.13	14.01	17	18164	130	29556216
Iridocyclitis	69.62	14.01	28	18153	1412	29554934
Musculoskeletal injury	69.25	14.01	16	18165	111	29556235
Mycotic allergy	66.93	14.01	18	18163	246	29556100
Vitritis	65.21	14.01	22	18159	671	29555675
Spirometry abnormal	64.97	14.01	19	18162	358	29555988
Mite allergy	63.67	14.01	18	18163	299	29556047
Iris hypopigmentation	59.88	14.01	12	18169	37	29556309
Conjunctivitis allergic	58.67	14.01	20	18161	630	29555716
Ototoxicity	57.42	14.01	25	18156	1540	29554806
Dust allergy	55.97	14.01	18	18163	471	29555875
Product use in unapproved indication	54.47	14.01	146	18035	86729	29469617
Painful respiration	53.91	14.01	22	18159	1152	29555194
Conjunctival hyperaemia	49.89	14.01	25	18156	2120	29554226
Walking aid user	49.05	14.01	22	18159	1455	29554891
Pathogen resistance	48.29	14.01	40	18141	8076	29548270
Multiple-drug resistance	48.22	14.01	30	18151	3870	29552476
Drug reaction with eosinophilia and systemic symptoms	46.92	14.01	71	18110	27921	29528425
Visual impairment	46.49	14.01	73	18108	29635	29526711
Chest injury	46.49	14.01	21	18160	1412	29554934
Keratitis fungal	45.58	14.01	10	18171	53	29556293
Corneal perforation	44.82	14.01	12	18169	161	29556185
Skin injury	44.67	14.01	19	18162	1105	29555241
Corneal epithelium defect	40.04	14.01	13	18168	351	29555995
Corneal opacity	39.42	14.01	14	18167	499	29555847
Death	39.38	14.01	96	18085	341988	29214358
Tendonitis	38.78	14.01	35	18146	7926	29548420
Condition aggravated	38.62	14.01	185	17996	146110	29410236
Iris atrophy	37.72	14.01	9	18172	73	29556273
Vision blurred	36.48	14.01	78	18103	40098	29516248
Tendon discomfort	36.27	14.01	11	18170	236	29556110
Diastasis recti abdominis	35.87	14.01	7	18174	18	29556328
Hypoacusis	35.38	14.01	44	18137	14379	29541967
NPM1 gene mutation	33.88	14.01	9	18172	117	29556229
Oral candidiasis	33.45	14.01	37	18144	10685	29545661
Cystoid macular oedema	32.95	14.01	13	18168	623	29555723
Cataract	32.28	14.01	53	18128	22325	29534021
Asthma	32.21	14.01	67	18114	33782	29522564
Vitreous opacities	32.11	14.01	10	18171	235	29556111
Tuberculoma of central nervous system	31.99	14.01	10	18171	238	29556108
Bronchiolitis obliterans syndrome	31.21	14.01	9	18172	161	29556185
Sleep disorder due to a general medical condition	31.03	14.01	21	18160	3125	29553221
Intentional product use issue	30.28	14.01	75	18106	42423	29513923
Urethritis mycoplasmal	30.06	14.01	6	18175	18	29556328
Ocular hyperaemia	29.34	14.01	32	18149	9095	29547251
Overdose	28.49	14.01	7	18174	79812	29476534
Chimerism	28.49	14.01	9	18172	222	29556124
Keratic precipitates	28.46	14.01	8	18173	130	29556216
Keratitis bacterial	28.11	14.01	7	18174	69	29556277
Infective keratitis	28.04	14.01	5	18176	6	29556340
Acute myeloid leukaemia recurrent	28.02	14.01	16	18165	1764	29554582
Tendon pain	27.84	14.01	18	18163	2482	29553864
Retinal detachment	27.67	14.01	23	18158	4663	29551683
Acoustic neuroma	27.64	14.01	8	18173	145	29556201
Eye abscess	27.59	14.01	8	18173	146	29556200
Persistent corneal epithelial defect	27.32	14.01	6	18175	32	29556314
Drug-induced liver injury	26.91	14.01	48	18133	21607	29534739
Toxicity to various agents	26.64	14.01	41	18140	173620	29382726
Corynebacterium infection	26.55	14.01	10	18171	422	29555924
Pigment dispersion syndrome	26.49	14.01	5	18176	10	29556336
Tuberculosis	26.28	14.01	27	18154	7169	29549177
Necrotising scleritis	26.05	14.01	6	18175	41	29556305
Aortic aneurysm	25.78	14.01	25	18156	6195	29550151
Product dose omission issue	25.11	14.01	14	18167	96369	29459977
Flat anterior chamber of eye	24.69	14.01	6	18175	53	29556293
Sitting disability	24.61	14.01	7	18174	119	29556227
Corneal scar	24.08	14.01	7	18174	129	29556217
Tinnitus	23.91	14.01	38	18143	15576	29540770
Anterior chamber inflammation	23.84	14.01	8	18173	240	29556106
Fibrin	23.34	14.01	4	18177	3	29556343
Mycobacterium chelonae infection	23.24	14.01	10	18171	598	29555748
Detachment of retinal pigment epithelium	23.20	14.01	9	18172	412	29555934
Conjunctival oedema	22.88	14.01	9	18172	428	29555918
Deafness unilateral	22.34	14.01	14	18167	1829	29554517
Dehydration	21.83	14.01	23	18158	114725	29441621
Vitreous haemorrhage	21.21	14.01	14	18167	1999	29554347
Photophobia	21.00	14.01	22	18159	5973	29550373
Foreign body sensation in eyes	20.83	14.01	9	18172	544	29555802
Axonal neuropathy	20.45	14.01	10	18171	804	29555542
Deafness neurosensory	20.30	14.01	15	18166	2563	29553783
Immune reconstitution inflammatory syndrome associated tuberculosis	19.90	14.01	8	18173	403	29555943
Blood immunoglobulin G decreased	19.82	14.01	11	18170	1148	29555198
Corneal transplant	19.58	14.01	5	18176	55	29556291
Herpes zoster meningoencephalitis	19.33	14.01	7	18174	264	29556082
Blepharitis allergic	19.19	14.01	3	18178	0	29556346
Chondritis	19.15	14.01	6	18175	144	29556202
Cardiovascular disorder	18.39	14.01	25	18156	8910	29547436
Drug hypersensitivity	18.36	14.01	87	18094	68319	29488027
Metamorphopsia	18.35	14.01	8	18173	494	29555852
Drug ineffective for unapproved indication	18.29	14.01	32	18149	14182	29542164
Incorrect product administration duration	18.19	14.01	17	18164	4024	29552322
Immune reconstitution inflammatory syndrome	17.86	14.01	23	18158	7779	29548567
Haematospermia	17.85	14.01	7	18174	330	29556016
Optic neuritis	17.82	14.01	15	18166	3094	29553252
Mechanical urticaria	17.63	14.01	5	18176	84	29556262
Deafness	17.54	14.01	26	18155	10029	29546317
Torsade de pointes	17.43	14.01	21	18160	6640	29549706
Masticatory pain	17.04	14.01	4	18177	30	29556316
Pulmonary venous thrombosis	16.96	14.01	5	18176	97	29556249
Nervous system disorder	16.92	14.01	29	18152	12645	29543701
Hospitalisation	16.47	14.01	4	18177	45984	29510362
Cerebrovascular accident	16.27	14.01	14	18167	76897	29479449
Emotional distress	16.24	14.01	30	18151	13865	29542481
Hypersomnia	16.23	14.01	26	18155	10728	29545618
Transaminases increased	16.14	14.01	40	18141	22622	29533724
Eye discharge	16.08	14.01	11	18170	1665	29554681
Eye oedema	16.03	14.01	8	18173	672	29555674
Disorganised speech	16.00	14.01	8	18173	675	29555671
Choroidal haematoma	15.89	14.01	3	18178	6	29556340
Ocular icterus	15.78	14.01	13	18168	2602	29553744
Vitreous floaters	15.75	14.01	14	18167	3107	29553239
Pupillary disorder	15.69	14.01	6	18175	264	29556082
Papilloma	15.69	14.01	5	18176	127	29556219
Incision site pain	15.47	14.01	11	18170	1772	29554574
Toxic optic neuropathy	15.38	14.01	8	18173	733	29555613
Product delivery mechanism issue	15.36	14.01	5	18176	136	29556210
Hallucination	15.15	14.01	61	18120	44651	29511695
Mycobacterial infection	15.07	14.01	11	18170	1845	29554501
Neurilemmoma benign	15.03	14.01	3	18178	9	29556337
Phosphorus metabolism disorder	15.03	14.01	3	18178	9	29556337
Feeling cold	14.95	14.01	23	18158	9168	29547178
Scleral thinning	14.79	14.01	3	18178	10	29556336
Pruritus genital	14.67	14.01	7	18174	533	29555813
Corneal disorder	14.65	14.01	8	18173	809	29555537
Pneumothorax	14.65	14.01	31	18150	15811	29540535
Eye infection fungal	14.61	14.01	6	18175	319	29556027
Eyelid oedema	14.46	14.01	16	18165	4620	29551726
Fall	14.44	14.01	58	18123	177120	29379226
Retinal oedema	14.40	14.01	7	18174	556	29555790
Punctate keratitis	14.35	14.01	6	18175	334	29556012
Malabsorption from administration site	14.23	14.01	4	18177	65	29556281

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Toxic anterior segment syndrome	361.44	12.22	110	40540	2329	64455753
Iris transillumination defect	358.60	12.22	64	40586	74	64458008
Endophthalmitis	297.64	12.22	116	40534	5249	64452833
Corneal oedema	285.59	12.22	91	40559	2252	64455830
Visual acuity reduced	275.32	12.22	186	40464	26955	64431127
Electrocardiogram QT prolonged	235.61	12.22	270	40380	79178	64378904
Hypopyon	230.58	12.22	64	40586	965	64457117
Contrast media allergy	227.76	12.22	75	40575	2066	64456016
Drug resistance	203.15	12.22	172	40478	34930	64423152
Eye pain	201.83	12.22	164	40486	31461	64426621
Drug hypersensitivity	193.52	12.22	448	40202	237367	64220715
Intraocular pressure increased	174.22	12.22	91	40559	8211	64449871
Ulcerative keratitis	164.87	12.22	65	40585	3032	64455050
Corneal infiltrates	160.33	12.22	37	40613	248	64457834
Delirium	154.67	12.22	204	40446	68990	64389092
Choroiditis	148.23	12.22	46	40604	1041	64457041
Mental disorder	133.69	12.22	120	40530	26325	64431757
Dysphoria	127.43	12.22	60	40590	4328	64453754
Corneal opacity	122.15	12.22	38	40612	867	64457215
Corneal epithelium defect	119.28	12.22	35	40615	650	64457432
Off label use	117.69	12.22	740	39910	632066	63826016
Anterior chamber cell	117.13	12.22	36	40614	788	64457294
Neuropathy peripheral	113.04	12.22	237	40413	117288	64340794
Vitritis	109.92	12.22	40	40610	1493	64456589
Paradoxical drug reaction	108.56	12.22	60	40590	6060	64452022
Uveitis	105.34	12.22	77	40573	12631	64445451
Drug reaction with eosinophilia and systemic symptoms	103.28	12.22	148	40502	54069	64404013
Obliterative bronchiolitis	98.13	12.22	43	40607	2622	64455460
Corneal perforation	97.72	12.22	30	40620	654	64457428
Conjunctival hyperaemia	94.18	12.22	47	40603	3852	64454230
Hepatotoxicity	91.08	12.22	119	40531	39843	64418239
Pigment dispersion syndrome	90.84	12.22	16	40634	16	64458066
Iris hypopigmentation	81.07	12.22	16	40634	43	64458039
Ocular hyperaemia	79.47	12.22	84	40566	22480	64435602
Asthma	79.00	12.22	181	40469	95044	64363038
Iris atrophy	75.71	12.22	17	40633	99	64457983
Ototoxicity	75.29	12.22	36	40614	2687	64455395
Iridocyclitis	74.42	12.22	37	40613	3008	64455074
Pathogen resistance	73.64	12.22	62	40588	12481	64445601
Vision blurred	73.08	12.22	170	40480	90146	64367936
Torsade de pointes	72.76	12.22	71	40579	17292	64440790
Tuberculoma of central nervous system	69.51	12.22	22	40628	532	64457550
Tendonitis	68.77	12.22	74	40576	20208	64437874
Spirometry abnormal	68.66	12.22	22	40628	554	64457528
Tinnitus	66.20	12.22	94	40556	34039	64424043
Musculoskeletal injury	64.02	12.22	16	40634	156	64457926
Anaphylactic reaction	63.11	12.22	136	40514	68528	64389554
Drug intolerance	62.28	12.22	259	40391	187733	64270349
Loss of employment	61.36	12.22	28	40622	1879	64456203
Oesophageal spasm	59.70	12.22	30	40620	2495	64455587
Retinal haemorrhage	59.45	12.22	44	40606	7354	64450728
Tendon pain	58.35	12.22	37	40613	4811	64453271
Death	58.27	12.22	137	40513	482568	63975514
Multiple-drug resistance	57.54	12.22	41	40609	6461	64451621
Punctate keratitis	56.23	12.22	21	40629	844	64457238
Toxicity to various agents	55.25	12.22	90	40560	363423	64094659
Total lung capacity increased	52.73	12.22	19	40631	689	64457393
Sputum purulent	52.46	12.22	22	40628	1204	64456878
Dust allergy	52.21	12.22	21	40629	1032	64457050
Visual impairment	50.93	12.22	131	40519	73946	64384136
Asthma-chronic obstructive pulmonary disease overlap syndrome	50.87	12.22	21	40629	1104	64456978
Corneal disorder	50.63	12.22	25	40625	2002	64456080
Upper respiratory tract infection	50.34	12.22	129	40521	72656	64385426
Arthropathy	50.26	12.22	8	40642	120959	64337123
Nicotine dependence	50.14	12.22	19	40631	795	64457287
Conjunctivitis allergic	49.21	12.22	20	40630	1010	64457072
Drug-induced liver injury	49.20	12.22	99	40551	47544	64410538
Product use in unapproved indication	48.41	12.22	230	40420	176388	64281694
Keratitis fungal	48.40	12.22	13	40637	172	64457910
Synovitis	47.50	12.22	4	40646	99086	64358996
Bronchitis chronic	47.30	12.22	30	40620	3902	64454180
Infective keratitis	47.05	12.22	10	40640	43	64458039
Persistent corneal epithelial defect	47.05	12.22	10	40640	43	64458039
Vitreous opacities	46.88	12.22	16	40634	493	64457589
Anterior chamber disorder	46.62	12.22	12	40638	133	64457949
Product dose omission issue	46.49	12.22	33	40617	194714	64263368
Acinetobacter infection	46.36	12.22	25	40625	2404	64455678
Mite allergy	44.99	12.22	17	40633	706	64457376
Photophobia	43.34	12.22	54	40596	17239	64440843
Wheezing	42.12	12.22	129	40521	80450	64377632
Oesophageal pain	42.03	12.22	26	40624	3237	64454845
Foreign body sensation in eyes	42.00	12.22	21	40629	1728	64456354
Fibrin	41.24	12.22	8	40642	19	64458063
Chest injury	40.82	12.22	23	40627	2410	64455672
Corneal flap complication	40.26	12.22	7	40643	6	64458076
Mycotic allergy	39.68	12.22	17	40633	981	64457101
Dehydration	38.51	12.22	48	40602	216715	64241367
Tendon discomfort	37.44	12.22	13	40637	422	64457660
NPM1 gene mutation	37.39	12.22	10	40640	130	64457952
Fall	37.36	12.22	136	40514	416690	64041392
Full blood count abnormal	37.09	12.22	67	40583	29690	64428392
Nasal polyps	37.08	12.22	25	40625	3604	64454478
Cataract	36.63	12.22	92	40558	51170	64406912
Keratitis bacterial	36.58	12.22	10	40640	142	64457940
Psoriasis	35.81	12.22	113	40537	71590	64386492
Painful respiration	35.80	12.22	23	40627	3058	64455024
Systemic lupus erythematosus	34.92	12.22	4	40646	77608	64380474
Dysbiosis	34.78	12.22	15	40635	880	64457202
Deafness	34.77	12.22	50	40600	18309	64439773
Diastasis recti abdominis	34.66	12.22	7	40643	22	64458060
Overdose	34.34	12.22	30	40620	159536	64298546
Pupillary disorder	33.12	12.22	12	40638	442	64457640
Hallucination	33.01	12.22	111	40539	72677	64385405
Skin injury	32.96	12.22	19	40631	2080	64456002
Optic neuritis	31.80	12.22	32	40618	8084	64449998
Hyponatraemia	31.79	12.22	28	40622	148311	64309771
Lymphoedema	31.59	12.22	35	40615	9870	64448212
Factor V deficiency	31.14	12.22	8	40642	88	64457994
Bronchiolitis obliterans syndrome	31.13	12.22	10	40640	254	64457828
Secondary immunodeficiency	30.83	12.22	20	40630	2704	64455378
Chimerism	30.69	12.22	10	40640	266	64457816
Retinal detachment	30.43	12.22	31	40619	7945	64450137
Cystoid macular oedema	30.39	12.22	17	40633	1757	64456325
Urethritis mycoplasmal	29.91	12.22	6	40644	18	64458064
Alopecia	29.09	12.22	37	40613	165653	64292429
Suicide attempt	28.81	12.22	5	40645	71002	64387080
Stenotrophomonas infection	28.59	12.22	20	40630	3060	64455022
Hypoacusis	28.20	12.22	55	40595	25812	64432270
Immune reconstitution inflammatory syndrome	28.19	12.22	37	40613	12433	64445649
Retinal ischaemia	27.76	12.22	12	40638	708	64457374
Eye pruritus	27.75	12.22	37	40613	12622	64445460
Polyneuropathy	27.66	12.22	47	40603	19847	64438235
Treatment failure	27.65	12.22	146	40504	116670	64341412
Obstructive airways disorder	27.38	12.22	51	40599	23134	64434948
Corneal transplant	27.25	12.22	9	40641	250	64457832
Flat anterior chamber of eye	27.14	12.22	8	40642	151	64457931
Forced expiratory volume decreased	26.77	12.22	27	40623	6840	64451242
Optic neuropathy	26.67	12.22	19	40631	2992	64455090
Tendon rupture	25.99	12.22	33	40617	10734	64447348
Maternal exposure during pregnancy	25.98	12.22	14	40636	95870	64362212
Peripheral nerve injury	25.84	12.22	11	40639	625	64457457
Non-infectious endophthalmitis	25.81	12.22	9	40641	296	64457786
Eye abscess	25.78	12.22	9	40641	297	64457785
Acute myeloid leukaemia recurrent	25.66	12.22	18	40632	2766	64455316
Hyperkalaemia	25.65	12.22	16	40634	101113	64356969
Bronchial ulceration	25.48	12.22	4	40646	0	64458082
Metamorphopsia	25.45	12.22	13	40637	1119	64456963
Retinal vasculitis	25.29	12.22	13	40637	1134	64456948
Hypotension	25.25	12.22	139	40511	380835	64077247
Eye oedema	25.08	12.22	15	40635	1758	64456324
Herpes zoster	24.55	12.22	107	40543	79080	64379002
Sleep disorder due to a general medical condition	24.39	12.22	28	40622	8206	64449876
Corynebacterium infection	24.30	12.22	12	40638	961	64457121
Iris adhesions	24.24	12.22	10	40640	525	64457557
Acoustic neuroma	24.00	12.22	8	40642	229	64457853
Cerebrovascular accident	23.86	12.22	31	40619	137552	64320530
Bradycardia	23.35	12.22	24	40626	118195	64339887
Conjunctival oedema	23.29	12.22	12	40638	1052	64457030
Blepharitis allergic	23.24	12.22	4	40646	3	64458079
Sitting disability	22.96	12.22	7	40643	149	64457933
Corneal scar	22.89	12.22	8	40642	265	64457817
Injection site erythema	22.89	12.22	8	40642	70792	64387290
Aortic aneurysm	22.85	12.22	26	40624	7548	64450534
Haemostasis	22.75	12.22	8	40642	270	64457812
Fatigue	22.69	12.22	334	40316	748396	63709686
Acute kidney injury	22.65	12.22	178	40472	449062	64009020
Corneal thinning	22.61	12.22	7	40643	157	64457925
Eye inflammation	22.51	12.22	21	40629	4836	64453246
Lacrimation increased	22.47	12.22	41	40609	18305	64439777
Skin reaction	22.46	12.22	33	40617	12319	64445763
Nosocomial infection	22.45	12.22	16	40634	2521	64455561
Keratic precipitates	22.05	12.22	8	40642	296	64457786
Detachment of retinal pigment epithelium	21.96	12.22	10	40640	668	64457414
Herpes zoster meningoencephalitis	21.79	12.22	10	40640	680	64457402
Eye discharge	21.69	12.22	21	40629	5063	64453019
Rhinitis allergic	21.49	12.22	26	40624	8052	64450030
Necrotising scleritis	21.28	12.22	7	40643	192	64457890
Vanishing bile duct syndrome	21.23	12.22	12	40638	1265	64456817
Intentional product use issue	21.08	12.22	117	40533	95247	64362835
Wound	20.96	12.22	11	40639	76466	64381616
Immune reconstitution inflammatory syndrome associated tuberculosis	20.71	12.22	10	40640	763	64457319
Headache	20.56	12.22	224	40426	529243	63928839
Eye infection staphylococcal	20.52	12.22	6	40644	110	64457972
Productive cough	20.51	12.22	96	40554	73107	64384975
Anterior chamber pigmentation	20.20	12.22	4	40646	11	64458071
Bronchitis	19.92	12.22	127	40523	108616	64349466
Walking aid user	19.70	12.22	22	40628	6259	64451823
Sputum discoloured	19.50	12.22	38	40612	17818	64440264
Vitreal cells	19.46	12.22	5	40645	55	64458027
Mediastinal effusion	19.46	12.22	5	40645	55	64458027
Hepatic steatosis	19.44	12.22	53	40597	30954	64427128
Haematospermia	19.34	12.22	7	40643	257	64457825
Aqueous humour leakage	19.11	12.22	3	40647	0	64458082
Gonioscopy abnormal	19.11	12.22	3	40647	0	64458082
Incorrect product administration duration	19.10	12.22	27	40623	9731	64448351
Nocardiosis	19.05	12.22	19	40631	4748	64453334
Corneal neovascularisation	18.96	12.22	6	40644	145	64457937
Gastroenteritis staphylococcal	18.94	12.22	7	40643	273	64457809
Eye irritation	18.87	12.22	35	40615	15821	64442261
Thrombocytopenia	18.48	12.22	219	40431	223582	64234500
Increased viscosity of bronchial secretion	18.42	12.22	8	40642	477	64457605
Injection site pain	18.41	12.22	26	40624	111382	64346700
Corneal erosion	18.40	12.22	7	40643	296	64457786
Drug ineffective for unapproved indication	18.32	12.22	52	40598	31081	64427001
Morganella infection	18.22	12.22	10	40640	996	64457086
Anterior chamber inflammation	18.17	12.22	8	40642	493	64457589
Caffeine allergy	18.16	12.22	4	40646	21	64458061
Forced vital capacity abnormal	18.16	12.22	4	40646	21	64458061
Axonal neuropathy	18.12	12.22	12	40638	1680	64456402
Oral candidiasis	18.00	12.22	43	40607	23169	64434913
Rash morbilliform	17.85	12.22	19	40631	5122	64452960
Mycobacterium chelonae infection	17.82	12.22	13	40637	2124	64455958
Implant site hypersensitivity	17.71	12.22	4	40646	24	64458058
Language disorder	17.13	12.22	14	40636	2703	64455379
Pericarditis	17.12	12.22	9	40641	62507	64395575
Stevens-Johnson syndrome	17.12	12.22	54	40596	34195	64423887
Phosphorus metabolism disorder	17.03	12.22	3	40647	3	64458079
Vitreous degeneration	16.94	12.22	4	40646	30	64458052
Corneal deposits	16.92	12.22	7	40643	370	64457712
Biopsy colon abnormal	16.88	12.22	5	40645	96	64457986
Pneumothorax	16.72	12.22	43	40607	24255	64433827
Sarcoidosis	16.71	12.22	20	40630	6126	64451956
Cough	16.58	12.22	275	40375	301873	64156209
Eosinophilic pneumonia acute	16.57	12.22	9	40641	878	64457204
Masticatory pain	16.50	12.22	4	40646	34	64458048
Blister	16.49	12.22	16	40634	80951	64377131
Dysmetria	16.48	12.22	9	40641	887	64457195
Multiple sclerosis relapse	16.46	12.22	3	40647	41132	64416950
Lethargy	16.41	12.22	13	40637	72581	64385501
Scleral thinning	16.39	12.22	4	40646	35	64458047
Neoplasm progression	16.37	12.22	3	40647	40961	64417121
Pulmonary venous thrombosis	16.33	12.22	5	40645	108	64457974
Paraneoplastic syndrome	16.33	12.22	9	40641	904	64457178
Anaphylactic shock	16.25	12.22	49	40601	30279	64427803
Back pain	16.16	12.22	92	40558	250079	64208003
Malignant neoplasm progression	16.14	12.22	29	40621	112842	64345240
Vitreous floaters	16.13	12.22	20	40630	6353	64451729
Choroidal neovascularisation	16.06	12.22	7	40643	421	64457661
Toxic optic neuropathy	16.02	12.22	9	40641	938	64457144
Hyperalbuminaemia	15.83	12.22	4	40646	41	64458041
Tuberculosis	15.79	12.22	29	40621	13009	64445073
Eyelid oedema	15.75	12.22	28	40622	12251	64445831
Weight increased	15.72	12.22	75	40575	213273	64244809
Eye infection fungal	15.71	12.22	7	40643	444	64457638
Respiratory moniliasis	15.61	12.22	6	40644	261	64457821
Vitreous haemorrhage	15.58	12.22	14	40636	3071	64455011
Aqueous fibrin	15.53	12.22	5	40645	128	64457954
Macular fibrosis	15.47	12.22	8	40642	706	64457376
Respiratory arrest	15.47	12.22	7	40643	52978	64405104
Incision site pain	15.33	12.22	13	40637	2641	64455441
Cellulitis	15.33	12.22	22	40628	93635	64364447
Ventricular tachycardia	15.30	12.22	52	40598	34213	64423869
Rash erythematous	15.29	12.22	66	40584	48567	64409515
Complications of transplant surgery	15.22	12.22	8	40642	731	64457351
Blood immunoglobulin G decreased	15.21	12.22	13	40637	2670	64455412
Urinary tract infection	15.05	12.22	85	40565	231511	64226571
Nervous system disorder	15.02	12.22	40	40610	23038	64435044
Cutis laxa	14.97	12.22	5	40645	144	64457938
Chondritis	14.87	12.22	5	40645	147	64457935
Suspected counterfeit product	14.84	12.22	7	40643	507	64457575
Anterior chamber flare	14.74	12.22	5	40645	151	64457931
Coronary artery disease	14.72	12.22	10	40640	60423	64397659
Dysdiadochokinesis	14.61	12.22	6	40644	311	64457771
Chest discomfort	14.61	12.22	124	40526	115982	64342100
Injection site swelling	14.57	12.22	4	40646	41349	64416733
AIDS related complication	14.55	12.22	4	40646	58	64458024
Choroidal detachment	14.48	12.22	7	40643	535	64457547
Retinal artery occlusion	14.32	12.22	13	40637	2890	64455192
Anterior chamber fibrin	14.29	12.22	5	40645	166	64457916
Neurilemmoma benign	14.29	12.22	3	40647	12	64458070
Discomfort	14.25	12.22	18	40632	80860	64377222
Erythema of eyelid	14.25	12.22	11	40639	1957	64456125
Embolism venous	14.06	12.22	14	40636	3493	64454589
Haematemesis	14.05	12.22	6	40644	46993	64411089
Muscle spasms	13.97	12.22	44	40606	140979	64317103
Limb mass	13.88	12.22	13	40637	3008	64455074
Disorganised speech	13.68	12.22	10	40640	1640	64456442
Hyperglycaemia	13.68	12.22	11	40639	60957	64397125
Scleral disorder	13.65	12.22	5	40645	190	64457892
Ocular hypertension	13.64	12.22	9	40641	1252	64456830
Sinus pain	13.58	12.22	12	40638	2577	64455505
Cardio-respiratory arrest	13.43	12.22	26	40624	98367	64359715
Bronchopulmonary aspergillosis	13.36	12.22	34	40616	19051	64439031
Foreign body in eye	13.32	12.22	5	40645	204	64457878
Musculoskeletal stiffness	13.24	12.22	37	40613	123169	64334913
Tendon disorder	13.11	12.22	18	40632	6314	64451768
Pain in extremity	13.07	12.22	125	40525	302960	64155122
Gastrointestinal mucosa hyperaemia	12.94	12.22	6	40644	418	64457664
Cryptococcosis	12.94	12.22	12	40638	2743	64455339
Ocular icterus	12.90	12.22	16	40634	5082	64453000
Intentional product misuse	12.83	12.22	16	40634	72279	64385803
Vestibular disorder	12.77	12.22	11	40639	2282	64455800
Hypotony of eye	12.77	12.22	5	40645	229	64457853
Injection site pruritus	12.70	12.22	4	40646	37822	64420260
Skin odour abnormal	12.58	12.22	10	40640	1857	64456225
Disseminated mycobacterium avium complex infection	12.40	12.22	4	40646	103	64457979
Injection site reaction	12.37	12.22	7	40643	46657	64411425
Allergic cough	12.35	12.22	6	40644	464	64457618
Rash	12.31	12.22	377	40273	458172	63999910
FEV1/FVC ratio abnormal	12.22	12.22	3	40647	27	64458055

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	J01MA14	ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE QUINOLONE ANTIBACTERIALS Fluoroquinolones
ATC	S01AE07	SENSORY ORGANS OPHTHALMOLOGICALS ANTIINFECTIVES Fluoroquinolones
FDA CS	M0023650	Quinolones
MeSH PA	D000900	Anti-Bacterial Agents
MeSH PA	D000890	Anti-Infective Agents
MeSH PA	D000970	Antineoplastic Agents
MeSH PA	D004791	Enzyme Inhibitors
MeSH PA	D059005	Topoisomerase II Inhibitors
CHEBI has role	CHEBI:36047	antibacterial drugs
FDA EPC	N0000175937	Quinolone Antimicrobial

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Septicemic plague	indication	9012003	DOID:3481
Infection of skin AND/OR subcutaneous tissue	indication	19824006
Staphylococcal pneumonia	indication	22754005
Pneumonia due to Streptococcus	indication	34020007
Pneumonic plague	indication	38976008	DOID:10398
Pneumonia due to Mycoplasma pneumoniae	indication	46970008
Peritonitis	indication	48661000
Bacterial pneumonia	indication	53084003	DOID:874
Pneumonia due to Klebsiella pneumoniae	indication	64479007
Haemophilus influenzae pneumonia	indication	70036007
Rhinoscleroma	indication	72409005	DOID:11336
Abdominal abscess	indication	75100008
Acute bacterial sinusitis	indication	75498004
Infectious disease of abdomen	indication	128070006
Bacterial conjunctivitis	indication	128350005	DOID:9700
Infection due to Enterobacteriaceae	indication	128945009
Bacterial infection due to Klebsiella pneumoniae	indication	186435004
Pneumococcal pneumonia	indication	233607000
Chlamydial pneumonia	indication	233609002
Streptococcus pyogenes infection	indication	302809008
Infection due to Staphylococcus aureus	indication	406602003
Acute exacerbation of chronic bronchitis	indication	425748003
Complicated Skin and Skin Structure E. Coli Infection	indication
Complicated Skin and Skin Structure Infection	indication
Haemophilus Influenzae Chronic Bronchitis	indication
Complicated Skin and Skin Structure Staphylococcus Aureus Infection	indication
Haemophilus Parainfluenzae Chronic Bronchitis	indication
Streptococcus Pneumoniae Chronic Bronchitis	indication
Moraxella Catarrhalis Pneumonia	indication
Staphylococcus Chronic Bronchitis	indication
Klebsiella Pneumoniae Chronic Bronchitis	indication
Moraxella Catarrhalis Chronic Bronchitis	indication
Acute tuberculosis	off-label use	25629007
Pulmonary tuberculosis	off-label use	154283005	DOID:2957
Cirrhosis of liver	contraindication	19943007	DOID:5082
Torsades de pointes	contraindication	31722008
Transplantation of heart	contraindication	32413006
Tendinitis	contraindication	34840004	DOID:971
Hypokalemia	contraindication	43339004
Conduction disorder of the heart	contraindication	44808001
Bradycardia	contraindication	48867003
Transplant of kidney	contraindication	70536003
Epilepsy	contraindication	84757009	DOID:1826
Transplant of lung	contraindication	88039007
Myasthenia gravis	contraindication	91637004	DOID:437
Prolonged QT interval	contraindication	111975006
Liver function tests abnormal	contraindication	166603001
Drug-induced hepatitis	contraindication	235876009
Peripheral nerve disease	contraindication	302226006
Pseudomembranous enterocolitis	contraindication	397683000
Myocardial ischemia	contraindication	414795007	DOID:3393
Traumatic rupture of tendon	contraindication	415749005
Congenital long QT syndrome	contraindication	442917000
Severe Cerebral Arteriosclerosis	contraindication

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	6.23	acidic
pKa2	8.54	Basic
pKa3	2.92	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Topoisomerase IV	Enzyme		PARC_ECOLI PARE_ECOLI	INHIBITOR				CHEMBL	CHEMBL
DNA gyrase	Enzyme		GYRA_ECOLI GYRB_ECOLI	INHIBITOR	IC50	6.52		CHEMBL	CHEMBL
DNA topoisomerase 4 subunit A	Enzyme		PARC_STAAU		IC50	6.10		CHEMBL
DNA gyrase subunit A	Enzyme		GYRA_MYCTU		IC50	5.04		CHEMBL

External reference:

ID	Source
D00874	KEGG_DRUG
186826-86-8	SECONDARY_CAS_RN
4021185	VANDF
4021186	VANDF
C0536495	UMLSCUI
CHEBI:63611	CHEBI
MFX	PDB_CHEM_ID
CHEMBL32	ChEMBL_ID
CHEMBL1200735	ChEMBL_ID
D000077266	MESH_DESCRIPTOR_UI
DB00218	DRUGBANK_ID
152946	PUBCHEM_CID
10915	IUPHAR_LIGAND_ID
7659	INN_ID
U188XYD42P	UNII
1047505	RXNORM
178916	MMSL
213098	MMSL
31558	MMSL
35332	MMSL
8580	MMSL
d04500	MMSL
007927	NDDF
007928	NDDF
116347002	SNOMEDCT_US
371296007	SNOMEDCT_US
412439003	SNOMEDCT_US

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
MOXEZA	HUMAN PRESCRIPTION DRUG LABEL	1	0065-0006	SOLUTION	5 mg	OPHTHALMIC	NDA	23 sections
VIGAMOX	HUMAN PRESCRIPTION DRUG LABEL	1	0065-4013	SOLUTION/ DROPS	5 mg	OPHTHALMIC	NDA	25 sections
VIGAMOX	HUMAN PRESCRIPTION DRUG LABEL	1	0065-4013	SOLUTION/ DROPS	5 mg	OPHTHALMIC	NDA	25 sections
VIGAMOX	HUMAN PRESCRIPTION DRUG LABEL	1	0078-0939	SOLUTION/ DROPS	5 mg	OPHTHALMIC	NDA	25 sections
Moxifloxacin Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0093-7387	TABLET, FILM COATED	400 mg	ORAL	ANDA	28 sections
Moxifloxacin Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0093-7387	TABLET, FILM COATED	400 mg	ORAL	ANDA	28 sections
Moxifloxacin	HUMAN PRESCRIPTION DRUG LABEL	1	0378-5430	SOLUTION/ DROPS	5 mg	OPHTHALMIC	ANDA	24 sections
Moxifloxacin Ophthalmic Solution	HUMAN PRESCRIPTION DRUG LABEL	1	0781-7135	SOLUTION/ DROPS	5 mg	OPHTHALMIC	NDA authorized generic	25 sections
Moxifloxacin Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	0832-1410	SOLUTION	5 mg	OPHTHALMIC	ANDA	26 sections
Moxifloxacin	HUMAN PRESCRIPTION DRUG LABEL	1	0904-6406	TABLET, FILM COATED	400 mg	ORAL	ANDA	30 sections
Moxifloxacin	HUMAN PRESCRIPTION DRUG LABEL	1	0904-6406	TABLET, FILM COATED	400 mg	ORAL	ANDA	30 sections
moxifloxacin hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	13668-201	TABLET	400 mg	ORAL	ANDA	29 sections
moxifloxacin hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	13668-201	TABLET	400 mg	ORAL	ANDA	29 sections
Avelox ABC Pack	HUMAN PRESCRIPTION DRUG LABEL	1	16590-881	TABLET, FILM COATED	400 mg	ORAL	NDA	17 sections
Moxifloxacin	HUMAN PRESCRIPTION DRUG LABEL	1	17478-519	SOLUTION/ DROPS	5 mg	OPHTHALMIC	ANDA	25 sections
VIGAMOX	HUMAN PRESCRIPTION DRUG LABEL	1	21695-968	SOLUTION	5 mg	OPHTHALMIC	NDA	20 sections
Moxifloxacin Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	40032-034	TABLET	400 mg	ORAL	ANDA	28 sections
Moxifloxacin	HUMAN PRESCRIPTION DRUG LABEL	1	50090-3147	TABLET, FILM COATED	400 mg	ORAL	ANDA	30 sections
Moxifloxacin Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	50090-4058	TABLET	400 mg	ORAL	ANDA	32 sections
Moxifloxacin Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	50090-4100	TABLET	400 mg	ORAL	ANDA	32 sections
Moxifloxacin ophthalmic solution	Human Prescription Drug Label	1	50090-4781	SOLUTION/ DROPS	5 mg	OPHTHALMIC	ANDA	24 sections
Moxifloxacin	HUMAN PRESCRIPTION DRUG LABEL	1	50090-5279	SOLUTION/ DROPS	5 mg	OPHTHALMIC	ANDA	24 sections
Moxifloxacin Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	50268-576	TABLET, FILM COATED	400 mg	ORAL	ANDA	30 sections
Moxifloxacin Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	50268-576	TABLET, FILM COATED	400 mg	ORAL	ANDA	30 sections
Moxifloxacin Hydrochloride	HUMAN PRESCRIPTION DRUG LABEL	1	51991-943	TABLET	400 mg	ORAL	ANDA	33 sections
Moxifloxacin ophthalmic solution	Human Prescription Drug Label	1	53002-2626	SOLUTION/ DROPS	5 mg	OPHTHALMIC	ANDA	24 sections
Avelox	HUMAN PRESCRIPTION DRUG LABEL	1	54868-4367	TABLET, FILM COATED	400 mg	ORAL	NDA	30 sections
VIGAMOX	HUMAN PRESCRIPTION DRUG LABEL	1	54868-4798	SOLUTION	5 mg	OPHTHALMIC	NDA	24 sections
Moxifloxacin	HUMAN PRESCRIPTION DRUG LABEL	1	55111-112	TABLET, FILM COATED	400 mg	ORAL	ANDA	30 sections
Moxifloxacin Hydrochloride	Human Prescription Drug Label	1	57237-156	TABLET, FILM COATED	400 mg	ORAL	ANDA	29 sections