DrugCentral 2023 ๐
2022 Update-Veterinary Drugs & Uses
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DrugCentral 2023 ๐
2022 Update-Veterinary Drugs & Uses
Search
Structure ๐
Similarity ๐
Smart API
Redial
About
Download
L1000
FAQ
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FDA-approved
EMA-approved
PMDA-approved
Target Card Uniprot Example:
P23975
temocillin ๐ถ
Veterinary Use |
Indications/Contra
| FAERs-F
| FAERs-M
| Orange Bk
| BioActivity |
Stem definition
Drug id
CAS RN
antibiotics, 6-aminopenicillanic acid derivatives
2587
66148-78-5
Description:
Molecule
Description
Molfile
Inchi
Smiles
Synonyms:
temocillin disodium
temocillin
beta-lactam antibiotic with unusual spectrum of antibacterial activity & exceptional stability to bacterial beta-lactamases; RN given refers to di-Na salt (2S-(2alpha,5alpha,6alpha))-isomer
Molecular weight: 414.45
Formula: C16H18N2O7S2
CLOGP: 1.51
LIPINSKI: 0
HAC: 9
HDO: 3
TPSA: 133.24
ALOGS: -3.61
ROTB: 6
Drug dosage:
Dose
Unit
Route
4
g
P
ADMET properties:
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Property
Value
Reference
t_half (Half-life)
4.10 hours
Lombardo F, Berellini G, Obach RS
BDDCS (Biopharmaceutical Drug Disposition Classification System)
3
Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)
147.72 ยตM/kg/day
Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
CL (Clearance)
0.34 mL/min/kg
Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)
0.21 %
Lombardo F, Berellini G, Obach RS
Vd (Volume of distribution)
0.11 L/kg
Lombardo F, Berellini G, Obach RS
Showing 1 to 6 of 6 entries
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Approvals:
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Date
Agency
Company
Orphan
Jan. 1, 1984
YEAR INTRODUCED
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FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
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Source
Code
Description
ATC
J01CA17
ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
BETA-LACTAM ANTIBACTERIALS, PENICILLINS
Penicillins with extended spectrum
MeSH PA
D000900
Anti-Bacterial Agents
MeSH PA
D000890
Anti-Infective Agents
Showing 1 to 3 of 3 entries
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Drug Use
| Suggest Off label Use Form|
|View source of the data|
None
๐ถ Veterinary Drug Use
None
๐ถ Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
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Dissociation level
Dissociation constant
Type (acidic/basic)
pKa1
3.01
acidic
pKa2
3.6
acidic
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Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
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ID
Source
TJ7
PDB_CHEM_ID
004049
NDDF
03QB156W6I
UNII
10926
IUPHAR_LIGAND_ID
171758
PUBCHEM_CID
37775
RXNORM
387543003
SNOMEDCT_US
5097
INN_ID
96065002
SNOMEDCT_US
C031367
MESH_SUPPLEMENTAL_RECORD_UI
Showing 1 to 10 of 15 entries
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Pharmaceutical products:
None
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temocillin