hetacillin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definition	Drug id	CAS RN
antibiotics, 6-aminopenicillanic acid derivatives	1363	3511-16-8

Description:

Molecule

Description

Molfile Inchi Smiles

Synonyms:

hetacillin potassium
hetacillin
etacillin
penplenum
phenazacillin

Molecular weight: 389.47
Formula: C19H23N3O4S
CLOGP: 0.81
LIPINSKI: 0
HAC: 7
HDO: 2
TPSA: 89.95
ALOGS: -2.88
ROTB: 3

Status: OFM

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
2	g	O

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

Property	Description	Value	Unit	Confidence	Similarity
kinase-safety-class	ACVR2A,ACVR2B,AURKA,AXL,BRAF,BTK,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,ERBB2,GRK2,GSK3B,ITK,JAK3,MAP2K6,MAP3K7,MAPK7,MAPKAPK2,NTRK2,PDK1,PDK2,PDK4,PIK3CB,PIM2,PRKDC,STK33,SYK,TEK,TGFBR1,ZAP70	34
kinase-selectivity-class	AXL,GRK2,MAP2K6	3
pfas-class	PFAS structural alert (1 = True, 0 = False)	0

Approvals:

Date	Agency	Company	Orphan
None	FDA	BRISTOL

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	J01CA18	ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE BETA-LACTAM ANTIBACTERIALS, PENICILLINS Penicillins with extended spectrum
CHEBI has role	CHEBI:33282	antibacterial agent
CHEBI has role	CHEBI:36047	antibacterial drug

Related Drugs by ATC class:

J01CA Penicillins with extended spectrum 18 drugs

amoxicillin ampicillin aspoxicillin azlocillin bacampicillin carbenicillin carindacillin epicillin mecillinam metampicillin mezlocillin piperacillin show all 18 →

Drug Use | Suggest Off label Use Form| |View source of the data|

None

🐶 Veterinary Drug Use

Species	Use	Relation
Cats	Respiratory tract infections	Indication
Cats	Urinary tract infections	Indication
Cats	Gastrointestinal infections	Indication
Cats	Skin infections	Indication
Cats	Soft tissue infections	Indication
Cats	Postsurgical infections	Indication
Cattle	Acute bovine mastitis	Indication
Cattle	Chronic bovine mastitis	Indication
Cattle	Subclinical bovine mastitis	Indication
Dogs	Respiratory tract infections	Indication
Dogs	Urinary tract infections	Indication
Dogs	Gastrointestinal infections	Indication
Dogs	Skin infections	Indication
Dogs	Soft tissue infections	Indication
Dogs	Postsurgical infections	Indication

🐶 Veterinary products

Product	Applicant	Ingredients
Hetacin K Capsules Vet	Boehringer lngelheim Animal Health USA Inc.	1
Hetacin K Tablets	Boehringer lngelheim Animal Health USA Inc.	1
Hetacin K Oral Liquid	Boehringer lngelheim Animal Health USA Inc.	1
PolyMast Intramammary Infusion	Boehringer lngelheim Animal Health USA Inc.	1

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	3.03	acidic
pKa2	5.46	Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Penicillin-binding protein	Enzyme		Q54618_STREE Q75Y37_STREE Q75Y54_STREE Q75YD8_STREE Q75YK0_STREE Q9RET4_STREE	INHIBITOR				CHEMBL	CHEMBL

External reference:

ID	Source
D01074	KEGG_DRUG
5321-32-4	SECONDARY_CAS_RN
C0801924	UMLSCUI
CHEBI:5683	CHEBI
CHEMBL1201116	ChEMBL_ID
CHEMBL1201121	ChEMBL_ID
DB00739	DRUGBANK_ID
C100115	MESH_SUPPLEMENTAL_RECORD_UI
443387	PUBCHEM_CID
12263	IUPHAR_LIGAND_ID
1924	INN_ID
TN4JSC48CV	UNII
1299048	RXNORM
002705	NDDF
002706	NDDF
37691005	SNOMEDCT_US

Pharmaceutical products:

None