metampicillin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
antibiotics, 6-aminopenicillanic acid derivatives 1718 6489-97-0

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • metampicillin
  • methylenampicillin
  • fedacilina
  • pravacilin
  • Molecular weight: 361.42
  • Formula: C17H19N3O4S
  • CLOGP: 1.22
  • LIPINSKI: 0
  • HAC: 7
  • HDO: 2
  • TPSA: 99.07
  • ALOGS: -3.52
  • ROTB: 5

Drug dosage:

DoseUnitRoute
1.50 g O
1.50 g P

ADMET properties:

None

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
azlogd74 LogD at pH 7.4 -1.465 Moderate 0.76
caco2-efflux Caco-2 efflux ratio (BA/AB) 0.711 Moderate 0.76
caco2-intrinsic-papp Caco-2 intrinsic apparent permeability 0.438 10^-6 cm/s Moderate 0.76
dh-clint Dog hepatocyte intrinsic clearance 2.415 uL/min/10^6 cells Moderate 0.76
dppb Dog plasma protein binding (% unbound) 57.430 % Moderate 0.76
fcs-ppb Fetal calf serum protein binding (% unbound) 47.930 % Moderate 0.76
herg hERG pIC50 4.408 pIC50 Moderate 0.76
hh-clint Human hepatocyte intrinsic clearance 1.191 uL/min/10^6 cells Moderate 0.76
hlm-clint Human liver microsomal intrinsic clearance 3.076 uL/min/mg protein Moderate 0.76
hppb Human plasma protein binding (% unbound) 60.050 % Moderate 0.76
kinase-safety-class ACVR2A,ACVR2B,AURKA,AXL,BRAF,BTK,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,GRK2,GRK3,GSK3B,ITK,JAK2,JAK3,MAP2K6,MAP3K21,MAP3K7,MAPK10,MAPK7,MAPK9,MAPKAPK2,NTRK2,PDK1,PDK2,PIK3CB,PIM2,PRKDC,SIK2,STK33,SYK,TEK,TGFBR1,TTK,ZAP70 41
kinase-selectivity-class AXL,GRK2,MAP2K6,TGFBR1 4
mdck-mdr1-bcrp-efflux MDCK-MDR1-BCRP efflux ratio 0.410 Moderate 0.76
mdck-mdr1-efflux MDCK-MDR1 efflux ratio 0.557 Moderate 0.76
mh-clint Mouse hepatocyte intrinsic clearance 5.070 Moderate 0.76
mppb Mouse plasma protein binding (% unbound) 62.510 Moderate 0.76
nih-mdck-mdr1-efflux NIH MDCK-MDR1 efflux ratio 1.089 Moderate 0.76
pfas-class PFAS structural alert (1 = True, 0 = False) 0
pppb Pig plasma protein binding (% unbound) 47.870 % Moderate 0.76
rat-kpuu-brain Rat brain Kpuu 0.006 % Moderate 0.76
rh-clint Rat hepatocyte intrinsic clearance 2.104 uL/min/10^6 cells Moderate 0.76
rh-fuinc Rat hepatocyte fraction unbound in incubation 86.210 % Moderate 0.76
rppb Rat plasma protein binding (% unbound) 40.890 % Moderate 0.76
solubility-dd Solubility at pH 7.4 in DMSO 907.821 uM Moderate 0.76

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC J01CA14 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
BETA-LACTAM ANTIBACTERIALS, PENICILLINS
Penicillins with extended spectrum
CHEBI has role CHEBI:33282 antibacterial agent

Related Drugs by ATC class:

J01CA Penicillins with extended spectrum 18 drugs
amoxicillinampicillinaspoxicillinazlocillinbacampicillincarbenicillincarindacillinepicillinhetacillinmecillinammezlocillinpiperacillin show all 18 →

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 2.79 acidic
pKa2 13.98 acidic
pKa3 1.29 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
D07234 KEGG_DRUG
C0066082 UMLSCUI
CHEBI:52060 CHEBI
CHEMBL1908324 ChEMBL_ID
DB13836 DRUGBANK_ID
6713928 PUBCHEM_CID
12274 IUPHAR_LIGAND_ID
2570 INN_ID
G0H6U7VSTK UNII
29629 RXNORM
005845 NDDF

Pharmaceutical products:

None