carindacillin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definition	Drug id	CAS RN
antibiotics, 6-aminopenicillanic acid derivatives	508	35531-88-5

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: carindacillin carbenicillin indanyl carbenicillin indanyl ester cardinacillin indanyl carbenicillin carbenicillin indanyl sodium carindacillin sodium CP-15464-2	acid stable indanyl ester of carbenicillin for oral use; same side-effects as carbenicillin; minor descriptor (75-86); on line & INDEX MEDICUS search CARBENICILLIN/AA (75-86); RN given refers to (mono-Na salt(2S-(2alpha,5alpha,6beta))-isomer) Molecular weight: 494.56 Formula: C26H26N2O6S CLOGP: 4.18 LIPINSKI: 0 HAC: 8 HDO: 2 TPSA: 113.01 ALOGS: -5 ROTB: 7 Status: OFM Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

carindacillin
carbenicillin indanyl
carbenicillin indanyl ester
cardinacillin
indanyl carbenicillin
carbenicillin indanyl sodium
carindacillin sodium
CP-15464-2

acid stable indanyl ester of carbenicillin for oral use; same side-effects as carbenicillin; minor descriptor (75-86); on line & INDEX MEDICUS search CARBENICILLIN/AA (75-86); RN given refers to (mono-Na salt(2S-(2alpha,5alpha,6beta))-isomer)

Molecular weight: 494.56
Formula: C26H26N2O6S
CLOGP: 4.18
LIPINSKI: 0
HAC: 8
HDO: 2
TPSA: 113.01
ALOGS: -5
ROTB: 7

Status: OFM

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
4	g	O

ADMET properties:

None

Approvals:

Date	Agency	Company	Orphan
Oct. 26, 1972	FDA	PFIZER

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

Source	Code	Description
ATC	J01CA05	ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE BETA-LACTAM ANTIBACTERIALS, PENICILLINS Penicillins with extended spectrum
FDA CS	M0016152	Penicillins
FDA EPC	N0000175497	Penicillin-class Antibacterial
CHEBI has role	CHEBI:36047	antibacterial drugs
MeSH PA	D000900	Anti-Bacterial Agents
MeSH PA	D000890	Anti-Infective Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Bacterial urinary infection	indication	312124009

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	2.79	acidic
pKa2	10.77	acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Mechanism action	Bioact source	MoA source
Bacterial penicillin-binding protein	Enzyme		PBPA_ECOLI PBPB_ECOLI DACC_ECOLI PBP2_ECOLI FTSI_ECOLI DACA_ECOLI DACB_ECOLI	INHIBITOR				CHEMBL	CHEMBL

External reference:

ID	Source
4018408	VUID
N0000146734	NUI
D01283	KEGG_DRUG
2015	RXNORM
C0054667	UMLSCUI
CHEBI:52015	CHEBI
CHEBI:3393	CHEBI
0JM	PDB_CHEM_ID
CHEMBL1596	ChEMBL_ID
DB09319	DRUGBANK_ID
12276	IUPHAR_LIGAND_ID
C100244	MESH_SUPPLEMENTAL_RECORD_UI
26605-69-6	SECONDARY_CAS_RN
93184	PUBCHEM_CID
4352	MMSL
d00092	MMSL
34731007	SNOMEDCT_US
372713001	SNOMEDCT_US
63188000	SNOMEDCT_US
C0006976	UMLSCUI
CHEMBL1200991	ChEMBL_ID
DB00578	DRUGBANK_ID
4018408	VANDF
4019654	VANDF
3405	INN_ID
2516	INN_ID
D002228	MESH_DESCRIPTOR_UI
20824	PUBCHEM_CID
5V278481KE	UNII
002700	NDDF
002702	NDDF

Pharmaceutical products:

None