carindacillin 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
antibiotics, 6-aminopenicillanic acid derivatives 508 35531-88-5

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • carindacillin
  • carbenicillin indanyl
  • carbenicillin indanyl ester
  • cardinacillin
  • indanyl carbenicillin
  • carbenicillin indanyl sodium
  • carindacillin sodium
  • CP-15464-2
acid stable indanyl ester of carbenicillin for oral use; same side-effects as carbenicillin; minor descriptor (75-86); on line & INDEX MEDICUS search CARBENICILLIN/AA (75-86); RN given refers to (mono-Na salt(2S-(2alpha,5alpha,6beta))-isomer)
  • Molecular weight: 494.56
  • Formula: C26H26N2O6S
  • CLOGP: 4.18
  • LIPINSKI: 0
  • HAC: 8
  • HDO: 2
  • TPSA: 113.01
  • ALOGS: -5
  • ROTB: 7
  • Status: OFM
    • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
4 g O

ADMET properties:

PropertyValueReference
BA (Bioavailability) 35 %
BA (Bioavailability) 69 %

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,AURKA,AXL,BRAF,BTK,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,ERBB2,GRK2,GSK3B,ITK,JAK2,JAK3,MAP2K6,MAP3K21,MAP3K7,MAPK7,MAPKAPK2,NTRK2,PDK1,PDK2,PDK4,PIK3CB,PIK3CG,PIM2,PRKDC,STK33,SYK,TEK,TGFBR1,TTK,ZAP70 38
kinase-selectivity-class AXL,EIF2AK3,GRK2,MAP2K6 4
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

DateAgencyCompanyOrphan
Oct. 26, 1972 FDA PFIZER

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC J01CA05 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
BETA-LACTAM ANTIBACTERIALS, PENICILLINS
Penicillins with extended spectrum
FDA CS M0016152 Penicillins
FDA EPC N0000175497 Penicillin-class Antibacterial
CHEBI has role CHEBI:33282 antibacterial agent
CHEBI has role CHEBI:36047 antibacterial drug
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000900 Anti-Bacterial Agents

Related Drugs by ATC class:

J01CA Penicillins with extended spectrum 18 drugs
amoxicillinampicillinaspoxicillinazlocillinbacampicillincarbenicillinepicillinhetacillinmecillinammetampicillinmezlocillinpiperacillin show all 18 →

Drug Use | Suggest Off label Use Form| |View source of the data|

DiseaseRelationSNOMED_IDDOID
Bacterial urinary infection indication 312124009




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 2.79 acidic
pKa2 10.77 acidic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])		Mechanism
action		Bioact sourceMoA source
Bacterial penicillin-binding protein Enzyme INHIBITOR CHEMBL CHEMBL

External reference:

IDSource
4018408 VUID
N0000146734 NUI
D01283 KEGG_DRUG
2015 RXNORM
C0054667 UMLSCUI
CHEBI:52015 CHEBI
0JM PDB_CHEM_ID
CHEMBL1596 ChEMBL_ID
CHEMBL1200991 ChEMBL_ID
DB09319 DRUGBANK_ID
12276 IUPHAR_LIGAND_ID
26605-69-6 SECONDARY_CAS_RN
93184 PUBCHEM_CID
4352 MMSL
d00092 MMSL
34731007 SNOMEDCT_US
372713001 SNOMEDCT_US
63188000 SNOMEDCT_US
C0006976 UMLSCUI
DB00578 DRUGBANK_ID
20824 PUBCHEM_CID
3405 INN_ID
2516 INN_ID
4018408 VANDF
4019654 VANDF
C100244 MESH_SUPPLEMENTAL_RECORD_UI
D002228 MESH_DESCRIPTOR_UI
5V278481KE UNII
002700 NDDF
002702 NDDF
CHEBI:3393 CHEBI
5V278481KE INXIGHT DRUGS

Pharmaceutical products:

None