suloctidil Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
vasodilators 2536 54767-75-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • suloctidil
  • dulcotil
  • fluversin
  • loctidon
  • suloctidyl
  • sulodene
A peripheral vasodilator that was formerly used in the management of peripheral and cerebral vascular disorders. It is hepatotoxic and fatalities have occurred. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1312)
  • Molecular weight: 337.57
  • Formula: C20H35NOS
  • CLOGP: 5.99
  • LIPINSKI: 1
  • HAC: 2
  • HDO: 2
  • TPSA: 32.26
  • ALOGS: -5.54
  • ROTB: 12

Drug dosage:

None

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC C04AX19 CARDIOVASCULAR SYSTEM
PERIPHERAL VASODILATORS
PERIPHERAL VASODILATORS
Other peripheral vasodilators
MeSH PA D002317 Cardiovascular Agents
MeSH PA D014665 Vasodilator Agents

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.4 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Alpha-2A adrenergic receptor GPCR Ki 6.12 DRUG MATRIX
Sigma non-opioid intracellular receptor 1 Membrane receptor Ki 7.31 DRUG MATRIX
Sodium-dependent serotonin transporter Transporter Ki 6.18 DRUG MATRIX
Sodium-dependent noradrenaline transporter Transporter Ki 5.86 DRUG MATRIX
5-hydroxytryptamine receptor 1A GPCR Ki 6.51 DRUG MATRIX
5-hydroxytryptamine receptor 2B GPCR Ki 6.22 DRUG MATRIX
D(3) dopamine receptor GPCR Ki 6.15 DRUG MATRIX
Histamine H1 receptor GPCR Ki 5.61 DRUG MATRIX
Histamine H2 receptor GPCR Ki 7.05 DRUG MATRIX
Muscarinic acetylcholine receptor M1 GPCR Ki 5.96 DRUG MATRIX
Muscarinic acetylcholine receptor M3 GPCR Ki 6.01 DRUG MATRIX
Muscarinic acetylcholine receptor M4 GPCR Ki 6.20 DRUG MATRIX
Muscarinic acetylcholine receptor M5 GPCR Ki 5.49 DRUG MATRIX
Beta-3 adrenergic receptor GPCR Ki 5.43 DRUG MATRIX
Alpha-2C adrenergic receptor GPCR Ki 6.30 DRUG MATRIX
Sodium-dependent dopamine transporter Transporter Ki 5.69 DRUG MATRIX
Adenosine receptor A3 GPCR Ki 5.68 DRUG MATRIX
Epidermal growth factor receptor Kinase IC50 6.10 DRUG MATRIX
Tyrosine-protein kinase Fyn Kinase IC50 6.14 DRUG MATRIX
Substance-K receptor GPCR Ki 5.65 DRUG MATRIX
5-hydroxytryptamine receptor 1A GPCR IC50 6.26 CHEMBL

External reference:

IDSource
D05967 KEGG_DRUG
004172 NDDF
CHEMBL404849 ChEMBL_ID
CHEMBL588119 ChEMBL_ID
XV1N1XY17K UNII
3452 INN_ID
5354 PUBCHEM_CID
D013468 MESH_DESCRIPTOR_UI
DB13340 DRUGBANK_ID

Pharmaceutical products:

None