AI ASSISTANT

Ask DrugCentral

Explore drug properties, targets, and indications with answers grounded in DrugCentral.

Your question

Ask in your own words. Each question is answered independently.

Explore sample questions

Select a question to fill the editor, then ask it or make it your own.

DrugCentral answer

Your answer will appear here. Open linked drug cards in a new tab to explore the source details.

AI can make mistakes. Verify answers against the original sources before relying on them.

Tox | Related Drugs | BioActivity |

Stem definition	Drug id	CAS RN
psychotropics, phenylpiperazine derivatives	242	129722-12-9

Description:

Molecule	Description
Molfile Inchi Smiles Synonyms: aripiprazole hydrate aripiprazole abilify arpizol pripiprazole OPC-14597	A piperazine and quinolone derivative that is used primarily as an antipsychotic agent. It is a partial agonist of SEROTONIN RECEPTOR, 5-HT1A and DOPAMINE D2 RECEPTORS, where it also functions as a post-synaptic antagonist, and an antagonist of SEROTONIN RECEPTOR, 5-HT2A. It is used for the treatment of SCHIZOPHRENIA and BIPOLAR DISORDER, and as an adjunct therapy for the treatment of depression. Molecular weight: 448.39 Formula: C23H27Cl2N3O2 CLOGP: 5.11 LIPINSKI: 1 HAC: 5 HDO: 1 TPSA: 44.81 ALOGS: -4.76 ROTB: 7 Status: OFP Legend: OFP - off patent OFM - off market ONP - on patent

Molecule

Description

Molfile Inchi Smiles

Synonyms:

aripiprazole hydrate
aripiprazole
abilify
arpizol
pripiprazole
OPC-14597

A piperazine and quinolone derivative that is used primarily as an antipsychotic agent. It is a partial agonist of SEROTONIN RECEPTOR, 5-HT1A and DOPAMINE D2 RECEPTORS, where it also functions as a post-synaptic antagonist, and an antagonist of SEROTONIN RECEPTOR, 5-HT2A. It is used for the treatment of SCHIZOPHRENIA and BIPOLAR DISORDER, and as an adjunct therapy for the treatment of depression.

Molecular weight: 448.39
Formula: C23H27Cl2N3O2
CLOGP: 5.11
LIPINSKI: 1
HAC: 5
HDO: 1
TPSA: 44.81
ALOGS: -4.76
ROTB: 7

Status: OFP

Legend:
OFP - off patent
OFM - off market
ONP - on patent

Drug dosage:

Dose	Unit	Route
15	mg	O
13.30	mg	P
15	mg	P

ADMET properties:

Property	Value	Reference
BDDCS (Biopharmaceutical Drug Disposition Classification System)	2	Benet LZ, Broccatelli F, Oprea TI
S (Water solubility)	0.00 mg/mL	Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine)	0.50 %	Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose)	0.56 µM/kg/day	Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability)	87 %	Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution)	4.90 L/kg	Lombardo F, Berellini G, Obach RS
CL (Clearance)	0.83 mL/min/kg	Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma)	0.01 %	Lombardo F, Berellini G, Obach RS
t_half (Half-life)	75 hours	Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

Property	Description	Value	Unit	Confidence	Similarity
azlogd74	LogD at pH 7.4	4.445		High	1
caco2-efflux	Caco-2 efflux ratio (BA/AB)	1.069		High	1
caco2-intrinsic-papp	Caco-2 intrinsic apparent permeability	11.324	10^-6 cm/s	High	1
dh-clint	Dog hepatocyte intrinsic clearance	16.749	uL/min/10^6 cells	High	1
dppb	Dog plasma protein binding (% unbound)	0.360	%	High	1
fcs-ppb	Fetal calf serum protein binding (% unbound)	1.700	%	High	1
herg	hERG pIC50	5.895	pIC50	High	1
hh-clint	Human hepatocyte intrinsic clearance	5.383	uL/min/10^6 cells	High	1
hlm-clint	Human liver microsomal intrinsic clearance	36.983	uL/min/mg protein	High	1
hppb	Human plasma protein binding (% unbound)	0.280	%	High	1
kinase-safety-class	ACVR2B,AKT2,AKT3,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,EIF2AK3,EPHB4,ERBB2,GRK2,ITK,JAK3,MAP3K7,MAPK10,MAPK7,MET,NTRK2,PDK1,PDK2,PDK4,PIK3CB,PIM2,PRKDC,SIK2,TEK,TGFBR1	30
kinase-selectivity-class	AXL,EIF2AK3,GRK2,PDK4	4
mdck-mdr1-efflux	MDCK-MDR1 efflux ratio	0.809		High	1
mh-clint	Mouse hepatocyte intrinsic clearance	38.994		High	1
mppb	Mouse plasma protein binding (% unbound)	0.400		High	1
nih-mdck-mdr1-efflux	NIH MDCK-MDR1 efflux ratio	3.027		High	1
pfas-class	PFAS structural alert (1 = True, 0 = False)	0
pld-class	Phospholipidosis risk class (1 = positive, 0 = negative)	1		High	1
pppb	Pig plasma protein binding (% unbound)	0.740	%	High	1
rh-clint	Rat hepatocyte intrinsic clearance	57.677	uL/min/10^6 cells	High	1
rh-fuinc	Rat hepatocyte fraction unbound in incubation	3.110	%	High	1
rppb	Rat plasma protein binding (% unbound)	0.320	%	High	1
solubility-dd	Solubility at pH 7.4 in DMSO	1.656	uM	High	1

Approvals:

Date	Agency	Company
Jan. 23, 2006	PMDA	Otsuka Pharmaceutical Co., Ltd
June 4, 2004	EMA
Nov. 15, 2002	FDA	OTSUKA

FDA Adverse Event Reporting System (Female)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Akathisia	2257.93	11.90	760	118254	10399	90499034
Tardive dyskinesia	2052.88	11.90	704	118310	10226	90499207
Dystonia	1701.85	11.90	688	118326	16131	90493302
Extrapyramidal disorder	1622.45	11.90	659	118355	15644	90493789
Suicide attempt	1417.25	11.90	1001	118013	74398	90435035
Sedation	1262.49	11.90	787	118227	47384	90462049
Dyskinesia	1261.06	11.90	713	118301	35821	90473612
Suicidal ideation	1193.58	11.90	895	118119	72960	90436473
Hallucination, auditory	1107.50	11.90	500	118514	15475	90493958
Sexual dysfunction	1050.37	11.90	347	118667	4457	90504976
Psychotic disorder	1030.73	11.90	592	118422	30638	90478795
Blood prolactin abnormal	1025.93	11.90	311	118703	2955	90506478
Parkinsonism	1022.15	11.90	455	118559	13610	90495823
Neuroleptic malignant syndrome	953.83	11.90	443	118571	14653	90494780
Drug interaction	951.21	11.90	1468	117546	274985	90234448
Treatment noncompliance	894.19	11.90	653	118361	51074	90458359
Delusion	824.54	11.90	390	118624	13450	90495983
Anosognosia	808.64	11.90	264	118750	3258	90506175
Product use in unapproved indication	754.97	11.90	1479	117535	334757	90174676
Mania	750.55	11.90	368	118646	13756	90495677
Hyperprolactinaemia	747.66	11.90	278	118736	5155	90504278
Disturbance in social behaviour	744.47	11.90	259	118755	3929	90505504
Tremor	734.56	11.90	954	118060	152219	90357214
Schizoaffective disorder	717.96	11.90	266	118748	4881	90504552
Weight increased	679.55	11.90	1613	117401	416314	90093119
Oculogyric crisis	676.81	11.90	212	118802	2267	90507166
Metabolic disorder	661.81	11.90	278	118736	7192	90502241
Intentional self-injury	608.22	11.90	414	118600	28920	90480513
Intentional overdose	606.03	11.90	680	118334	93154	90416279
Personality change	594.05	11.90	256	118758	7065	90502368
Electrocardiogram QT prolonged	591.90	11.90	595	118419	71861	90437572
Somnolence	527.04	11.90	967	118047	208117	90301316
Abnormal behaviour	513.92	11.90	338	118676	22290	90487143
Psychotic symptom	481.32	11.90	160	118854	2096	90507337
Restlessness	456.06	11.90	377	118637	35343	90474090
Agitation	439.53	11.90	490	118524	66608	90442825
Drug abuse	437.33	11.90	540	118474	81807	90427626
Salivary hypersecretion	424.42	11.90	217	118797	8875	90500558
Drug level increased	398.90	11.90	314	118700	27448	90481985
Joint swelling	394.87	11.90	89	118925	503211	90006222
Systemic lupus erythematosus	389.61	11.90	21	118993	361875	90147558
Aggression	381.82	11.90	301	118713	26367	90483066
Infusion related reaction	376.32	11.90	51	118963	416729	90092704
Stubbornness	370.84	11.90	90	118924	322	90509111
Glossodynia	365.01	11.90	13	119001	321766	90187667
Anxiety	356.10	11.90	1052	117962	308720	90200713
Gambling disorder	349.85	11.90	109	118905	1143	90508290
Galactorrhoea	348.55	11.90	154	118860	4518	90504915
Arthropathy	342.30	11.90	40	118974	366202	90143231
Psychiatric decompensation	333.19	11.90	117	118897	1826	90507607
Irritability	328.72	11.90	313	118701	35349	90474084
Contraindicated product administered	319.94	11.90	27	118987	320112	90189321
Swelling	313.13	11.90	82	118932	418976	90090457
Schizophrenia	310.30	11.90	211	118803	14703	90494730
Abdominal discomfort	306.23	11.90	122	118892	477206	90032227
Thinking abnormal	302.86	11.90	190	118824	11542	90497891
Blood glucose increased	292.49	11.90	481	118533	94765	90414668
Muscle rigidity	289.56	11.90	199	118815	14110	90495323
Pain	284.19	11.90	550	118464	995791	89513642
Arthralgia	283.25	11.90	365	118649	778157	89731276
Helicobacter infection	281.47	11.90	3	119011	226847	90282586
Blood prolactin increased	274.92	11.90	121	118893	3516	90505917
Completed suicide	262.52	11.90	585	118429	144473	90364960
Gestational diabetes	262.22	11.90	167	118847	10415	90499018
Pericarditis	261.27	11.90	26	118988	270125	90239308
Mental impairment	259.53	11.90	198	118816	16522	90492911
Metabolic syndrome	257.82	11.90	96	118918	1786	90507647
Alopecia	255.77	11.90	168	118846	494903	90014530
Drug intolerance	255.05	11.90	135	118879	447456	90061977
Folliculitis	247.83	11.90	4	119010	204349	90305084
Orthostatic hypertension	242.13	11.90	69	118945	516	90508917
Rash	239.53	11.90	425	118589	795675	89713758
Hypersensitivity	239.33	11.90	151	118863	454526	90054907
Rheumatoid arthritis	233.56	11.90	92	118922	362522	90146911
Overdose	230.16	11.90	585	118429	157124	90352309
Stomatitis	228.84	11.90	42	118972	274656	90234777
Underdose	224.30	11.90	314	118700	53703	90455730
Foetal exposure during pregnancy	223.52	11.90	279	118735	42696	90466737
Mental disorder	221.89	11.90	242	118772	32076	90477357
Persecutory delusion	220.96	11.90	100	118914	3108	90506325
Diarrhoea	218.33	11.90	579	118435	938611	89570822
Paranoia	216.21	11.90	160	118854	12748	90496685
Hepatic enzyme increased	215.67	11.90	102	118912	360634	90148799
Psychomotor hyperactivity	215.02	11.90	159	118855	12654	90496779
Muscle injury	211.96	11.90	4	119010	176650	90332783
Impaired healing	210.40	11.90	29	118985	234170	90275263
Dyspnoea	208.60	11.90	538	118476	880417	89629016
Irritable bowel syndrome	208.54	11.90	17	118997	207431	90302002
Sinusitis	208.20	11.90	95	118919	342993	90166440
Abortion spontaneous	206.49	11.90	302	118712	53754	90455679
Blister	203.97	11.90	43	118971	254955	90254478
Psychiatric symptom	203.38	11.90	123	118891	6995	90502438
Hallucinations, mixed	203.21	11.90	115	118899	5774	90503659
Impulse-control disorder	198.98	11.90	67	118947	915	90508518
Psoriatic arthropathy	198.81	11.90	31	118983	228304	90281129
Catatonia	197.55	11.90	114	118900	5942	90503491
Nasopharyngitis	197.16	11.90	148	118866	406956	90102477
Diabetes mellitus	192.90	11.90	323	118691	64552	90444881
Lower respiratory tract infection	191.02	11.90	47	118967	250612	90258821
Depression	190.67	11.90	841	118173	299760	90209673
Hallucination	190.29	11.90	324	118690	65635	90443798
Mobility decreased	187.25	11.90	49	118965	250685	90258748
Depressed mood	186.66	11.90	277	118737	49945	90459488
Wrong technique in product usage process	186.28	11.90	336	118678	71235	90438198
Mood altered	186.25	11.90	165	118849	16979	90492454
Serotonin syndrome	185.99	11.90	239	118775	37648	90471785
Blood creatine phosphokinase increased	185.17	11.90	226	118788	33797	90475636
Pneumonia	182.50	11.90	351	118663	637708	89871725
Discomfort	180.92	11.90	67	118947	274268	90235165
Sopor	175.24	11.90	188	118826	24456	90484977
Cogwheel rigidity	168.86	11.90	73	118941	2029	90507404
Drug hypersensitivity	168.60	11.90	217	118797	463392	90046041
Social avoidant behaviour	166.69	11.90	84	118930	3329	90506104
Compulsive shopping	165.89	11.90	55	118959	714	90508719
Wound	165.77	11.90	96	118918	302884	90206549
Apathy	165.34	11.90	128	118886	10912	90498521
Hallucination, visual	163.91	11.90	176	118838	22916	90486517
Bipolar disorder	163.26	11.90	117	118897	8868	90500565
Osteoarthritis	162.81	11.90	30	118984	195700	90313733
Therapeutic product effect decreased	160.51	11.90	82	118932	277489	90231944
Maternal exposure during pregnancy	157.45	11.90	907	118107	359156	90150277
Suppressed lactation	156.58	11.90	47	118967	430	90509003
Toxicity to various agents	156.50	11.90	770	118244	287076	90222357
Infarction	155.55	11.90	77	118937	2936	90506497
Joint range of motion decreased	155.39	11.90	5	119009	135638	90373795
Pruritus	154.66	11.90	298	118716	541227	89968206
Sleep disorder due to general medical condition, insomnia type	154.02	11.90	3	119011	128691	90380742
Wheezing	153.87	11.90	60	118954	238020	90271413
Peripheral swelling	153.68	11.90	190	118824	412916	90096517
Insurance issue	151.08	11.90	121	118893	10837	90498596
Hostility	150.70	11.90	69	118945	2204	90507229
Sinus tachycardia	149.68	11.90	186	118828	28327	90481106
General physical health deterioration	148.91	11.90	148	118866	354967	90154466
Caesarean section	148.72	11.90	151	118863	18426	90491007
Hypersexuality	148.05	11.90	48	118966	578	90508855
Increased appetite	147.67	11.90	123	118891	11642	90497791
Gastrointestinal disorder	145.20	11.90	78	118936	256609	90252824
C-reactive protein abnormal	144.90	11.90	5	119009	127424	90382009
Drug monitoring procedure incorrectly performed	144.41	11.90	41	118973	302	90509131
Ill-defined disorder	144.13	11.90	33	118981	184858	90324575
Hypomania	143.91	11.90	108	118906	8789	90500644
Disturbance in attention	140.63	11.90	235	118779	46874	90462559
Fibromyalgia	140.02	11.90	48	118966	206221	90303212
Posture abnormal	139.12	11.90	69	118945	2642	90506791
Antipsychotic drug level increased	139.11	11.90	77	118937	3702	90505731
Drooling	136.22	11.90	81	118933	4465	90504968
Infection	135.21	11.90	166	118848	361928	90147505
Musculoskeletal pain	132.62	11.90	31	118983	171220	90338213
Amenorrhoea	127.69	11.90	113	118901	11609	90497824
Vertigo	126.70	11.90	282	118732	69529	90439904
Substance abuse	123.31	11.90	81	118933	5325	90504108
Affective disorder	122.50	11.90	93	118921	7700	90501733
Muscle twitching	122.45	11.90	155	118859	24047	90485386
Seizure	122.03	11.90	459	118555	152170	90357263
Impulsive behaviour	119.38	11.90	54	118960	1676	90507757
Obsessive-compulsive disorder	118.91	11.90	74	118940	4430	90505003
Logorrhoea	118.39	11.90	62	118952	2665	90506768
Bursitis	116.56	11.90	17	118997	131637	90377796
Refusal of treatment by patient	116.55	11.90	80	118934	5658	90503775
Hyperphagia	116.47	11.90	62	118952	2756	90506677
Pulmonary fibrosis	116.30	11.90	6	119008	107497	90401936
Liver injury	115.22	11.90	40	118974	170527	90338906
Lip dry	114.64	11.90	4	119010	100951	90408482
Urticaria	112.95	11.90	147	118867	312587	90196846
Urinary retention	112.28	11.90	188	118826	37556	90471877
Inflammation	112.13	11.90	47	118967	178545	90330888
Urinary incontinence	111.60	11.90	187	118827	37379	90472054
Fatigue	111.25	11.90	976	118038	1153047	89356386
Depressive symptom	110.47	11.90	75	118939	5210	90504223
Abortion induced	103.22	11.90	101	118913	11787	90497646
Psychomotor retardation	102.58	11.90	69	118945	4720	90504713
Cognitive disorder	99.64	11.90	256	118758	69151	90440282
Rhabdomyolysis	98.62	11.90	212	118802	51044	90458389
Thermal burn	98.22	11.90	77	118937	6685	90502748
Pain in extremity	98.14	11.90	286	118728	450243	90059190
Inappropriate schedule of product administration	97.58	11.90	423	118591	149510	90359923
Grip strength decreased	97.58	11.90	6	119008	92570	90416863
Arthritis	97.32	11.90	49	118965	167266	90342167
Poisoning deliberate	97.06	11.90	114	118900	16372	90493061
Treatment failure	96.82	11.90	156	118858	303772	90205661
Peripheral venous disease	96.44	11.90	3	119011	83918	90425515
Wound infection	95.92	11.90	13	119001	106389	90403044
Depressed level of consciousness	95.88	11.90	260	118754	72524	90436909
Gambling	95.10	11.90	28	118986	238	90509195
Lung disorder	93.19	11.90	40	118974	149843	90359590
Anaemia	93.08	11.90	203	118811	352599	90156834
Acute myopia	92.90	11.90	25	118989	147	90509286
Anger	92.88	11.90	102	118912	13618	90495815
Rabbit syndrome	92.49	11.90	29	118985	311	90509122
Abdominal pain upper	92.31	11.90	186	118828	332488	90176945
Coma	92.24	11.90	256	118758	72376	90437057
Libido increased	91.31	11.90	45	118969	1699	90507734
Disease progression	90.89	11.90	46	118968	156569	90352864
Euphoric mood	90.48	11.90	67	118947	5342	90504091
Economic problem	89.39	11.90	55	118959	3226	90506207
Night sweats	89.05	11.90	29	118985	128737	90380696
Disinhibition	88.78	11.90	38	118976	1030	90508403
Eosinophil count decreased	87.91	11.90	54	118960	3158	90506275
Gaze palsy	87.88	11.90	43	118971	1598	90507835
Febrile neutropenia	86.79	11.90	50	118964	158299	90351134
Hypothermia	85.61	11.90	104	118910	15471	90493962
Sinus rhythm	85.43	11.90	40	118974	1346	90508087
Abdominal pain	84.86	11.90	253	118761	395468	90113965
Premature delivery	84.76	11.90	169	118845	38593	90470840
Abortion	84.27	11.90	50	118964	2745	90506688
Bradyphrenia	84.15	11.90	74	118940	7538	90501895
Malignant neoplasm progression	83.41	11.90	19	118995	106851	90402582
Flat affect	83.24	11.90	42	118972	1669	90507764
Antipsychotic drug level above therapeutic	82.40	11.90	39	118975	1345	90508088
Tic	81.68	11.90	43	118971	1868	90507565
Blood cholesterol increased	81.18	11.90	92	118922	207920	90301513
Pyrexia	80.29	11.90	523	118491	659962	89849471
Personality disorder	79.91	11.90	90	118924	12354	90497079
Acute psychosis	79.81	11.90	50	118964	3028	90506405
Injury	79.53	11.90	85	118929	197264	90312169
Pregnancy	79.09	11.90	219	118795	61828	90447605
Contusion	78.08	11.90	131	118883	251085	90258348
Hypertonia	77.70	11.90	60	118954	5095	90504338
Symptom recurrence	77.60	11.90	54	118960	3905	90505528
Myoclonus	77.43	11.90	110	118904	19058	90490375
Poor personal hygiene	75.91	11.90	26	118988	375	90509058
Pregnancy on contraceptive	75.60	11.90	36	118978	1259	90508174
Myocarditis	75.58	11.90	92	118922	13714	90495719
Bipolar I disorder	75.48	11.90	42	118972	2040	90507393
Altered state of consciousness	74.44	11.90	142	118872	31390	90478043
Mutism	73.34	11.90	39	118975	1730	90507703
Refusal of examination	73.22	11.90	22	118992	202	90509231
Intentional product use issue	73.20	11.90	107	118907	216785	90292648
Dysarthria	73.14	11.90	196	118818	54286	90455147
Personality change due to a general medical condition	71.70	11.90	23	118991	267	90509166
Dyspepsia	71.65	11.90	93	118921	198067	90311366
Oedema	71.40	11.90	95	118919	200200	90309233
Cough	71.34	11.90	247	118767	368715	90140718
Mood swings	70.97	11.90	110	118904	20592	90488841
Therapy cessation	70.64	11.90	151	118863	36210	90473223
Miosis	70.34	11.90	74	118940	9410	90500023
Autoimmune disorder	70.08	11.90	9	119005	76735	90432698
Eye movement disorder	70.02	11.90	61	118953	6137	90503296
Prescribed underdose	69.65	11.90	237	118777	74782	90434651
Knee arthroplasty	68.60	11.90	13	119001	83169	90426264
Off label use	68.56	11.90	1912	117102	1100340	89409093
Self-injurious ideation	68.25	11.90	46	118968	3157	90506276
Self-destructive behaviour	67.09	11.90	25	118989	466	90508967
Apraxia	66.98	11.90	40	118974	2222	90507211
Restless legs syndrome	66.93	11.90	112	118902	22358	90487075
Paraesthesia	66.84	11.90	143	118871	250183	90259250
Cardio-respiratory arrest	66.28	11.90	208	118806	62932	90446501
Loss of consciousness	66.27	11.90	361	118653	139877	90369556
Gait inability	66.08	11.90	57	118957	146399	90363034
Behaviour disorder	65.64	11.90	52	118962	4583	90504850
Decreased appetite	65.03	11.90	264	118750	376276	90133157
Torticollis	64.94	11.90	41	118973	2517	90506916
Sciatica	64.72	11.90	26	118988	101356	90408077
Insomnia	64.67	11.90	696	118318	332778	90176655
Blunted affect	64.54	11.90	21	118993	256	90509177
Trimethylaminuria	63.38	11.90	19	118995	173	90509260
Soliloquy	63.02	11.90	22	118992	337	90509096
Hypoaesthesia	63.01	11.90	207	118807	314003	90195430
Hip arthroplasty	62.66	11.90	12	119002	76196	90433237
Stupor	62.02	11.90	54	118960	5428	90504005
Binge eating	62.02	11.90	25	118989	580	90508853
Nail disorder	61.73	11.90	4	119010	59063	90450370
Disease recurrence	61.56	11.90	146	118868	37507	90471926
Neutrophil count increased	59.56	11.90	98	118916	19292	90490141
Hypercholesterolaemia	59.48	11.90	29	118985	100863	90408570
Victim of crime	59.48	11.90	27	118987	845	90508588
Post-traumatic stress disorder	59.26	11.90	58	118956	6770	90502663
Hypokinesia	58.91	11.90	87	118927	15610	90493823
Suicidal behaviour	58.59	11.90	40	118974	2804	90506629
Dysphagia	58.52	11.90	297	118717	111981	90397452
Lactation disorder	57.98	11.90	22	118992	432	90509001
Autism spectrum disorder	57.85	11.90	30	118984	1263	90508170
Nightmare	57.78	11.90	103	118911	21622	90487811
Compulsive sexual behaviour	57.70	11.90	14	119000	50	90509383
Bruxism	57.65	11.90	47	118967	4316	90505117
Enuresis	56.46	11.90	42	118972	3372	90506061
Dissociation	56.35	11.90	56	118958	6659	90502774
Lower limb fracture	55.59	11.90	21	118993	84992	90424441
Erythema	55.52	11.90	138	118876	229108	90280325
Inappropriate affect	55.31	11.90	27	118987	998	90508435
Withdrawal syndrome	55.11	11.90	103	118911	22421	90487012
Osteoporosis	55.03	11.90	29	118985	96502	90412931
Abulia	54.92	11.90	24	118990	685	90508748
Nausea	54.51	11.90	1080	117934	1109236	89400197
Crying	53.90	11.90	110	118904	25535	90483898
Hallucination, olfactory	53.61	11.90	19	118995	305	90509128
Product availability issue	53.54	11.90	57	118957	7347	90502086
Major depression	53.52	11.90	66	118948	9969	90499464
Colitis	53.46	11.90	13	119001	69929	90439504
Headache	52.97	11.90	806	118208	861940	89647493
Liver disorder	52.55	11.90	49	118965	121220	90388213
Back pain	52.50	11.90	226	118788	316949	90192484
Somnambulism	52.37	11.90	52	118962	6176	90503257
Speech disorder	52.36	11.90	155	118859	45430	90464003
Bradykinesia	52.20	11.90	54	118960	6734	90502699
Thrombocytopenia	51.84	11.90	124	118890	208601	90300832
Soft tissue injury	51.79	11.90	33	118981	2059	90507374
Alice in wonderland syndrome	51.56	11.90	12	119002	34	90509399
Upper respiratory tract infection	50.87	11.90	56	118958	128262	90381171
Chest pain	50.35	11.90	232	118782	319413	90190020
Blood triglycerides increased	49.82	11.90	75	118939	13686	90495747
Tachycardia	49.65	11.90	366	118648	157307	90352126
Threatened labour	49.50	11.90	24	118990	874	90508559
Right ventricular false tendon	49.45	11.90	10	119004	10	90509423
Rhesus incompatibility	49.21	11.90	14	119000	104	90509329
Movement disorder	49.05	11.90	114	118900	28905	90480528
Parkinsonian gait	49.00	11.90	21	118993	571	90508862
Bankruptcy	48.99	11.90	11	119003	25	90509408
Pleurothotonus	48.59	11.90	27	118987	1308	90508125
Liver function test increased	47.63	11.90	26	118988	84829	90424604
Stereotypy	47.29	11.90	19	118995	437	90508996
Psychomotor skills impaired	46.75	11.90	35	118979	2837	90506596
Hyperhidrosis	46.75	11.90	323	118691	135982	90373451
Homicidal ideation	46.37	11.90	29	118985	1751	90507682
Psychotic behaviour	46.33	11.90	21	118993	655	90508778
Mydriasis	46.28	11.90	76	118938	14936	90494497
Post-traumatic neck syndrome	46.28	11.90	33	118981	2481	90506952
Pulmonary embolism	46.05	11.90	312	118702	130508	90378925
Antipsychotic drug level below therapeutic	45.81	11.90	17	118997	313	90509120
Foot deformity	45.76	11.90	11	119003	59640	90449793
Mucosal inflammation	45.45	11.90	10	119004	57615	90451818
Drug screen false positive	45.44	11.90	23	118991	920	90508513
Substance use disorder	45.43	11.90	30	118984	1990	90507443
Meconium aspiration syndrome	45.41	11.90	10	119004	20	90509413
Asthenia	45.34	11.90	465	118549	533286	89976147
Product administered to patient of inappropriate age	45.08	11.90	42	118972	4611	90504822
Slow response to stimuli	44.98	11.90	24	118990	1072	90508361
Immunodeficiency	44.97	11.90	3	119011	43231	90466202
Hypersomnia	44.84	11.90	92	118922	21439	90487994
Syringe issue	44.43	11.90	39	118975	3963	90505470
Disorientation	44.18	11.90	143	118871	43971	90465462
Hepatic cirrhosis	44.16	11.90	14	119000	63239	90446194
Intellectual disability	44.06	11.90	25	118989	1261	90508172
Monocyte count increased	44.03	11.90	57	118957	9040	90500393
Red blood cell sedimentation rate increased	43.95	11.90	27	118987	82568	90426865
Lupus-like syndrome	43.94	11.90	6	119008	48840	90460593
Malignant catatonia	43.50	11.90	15	118999	221	90509212
Accidental exposure to product by child	43.23	11.90	25	118989	1308	90508125
Paradoxical drug reaction	42.78	11.90	45	118969	5721	90503712
Rectal haemorrhage	42.72	11.90	28	118986	82716	90426717
Drug ineffective	42.62	11.90	2222	116792	1382076	89127357
Adjustment disorder with depressed mood	42.50	11.90	11	119003	56742	90452691
Herpes zoster	42.49	11.90	37	118977	94607	90414826
Anhedonia	42.38	11.90	63	118951	11368	90498065
Drug withdrawal syndrome	42.30	11.90	107	118907	28616	90480817
Joint stiffness	42.24	11.90	25	118989	78017	90431416
Platelet count decreased	42.00	11.90	72	118942	136897	90372536
Trismus	41.93	11.90	41	118973	4780	90504653
Illusion	41.77	11.90	24	118990	1240	90508193
Asthma	41.01	11.90	171	118843	241989	90267444
Affect lability	40.99	11.90	80	118934	17983	90491450
Resting tremor	40.99	11.90	21	118993	862	90508571
Parkinsonian rest tremor	40.37	11.90	13	119001	153	90509280
Drug monitoring procedure not performed	40.29	11.90	20	118994	767	90508666
Selective eating disorder	40.23	11.90	28	118986	2025	90507408
Hospitalisation	40.12	11.90	297	118717	127803	90381630
Newborn persistent pulmonary hypertension	40.09	11.90	15	118999	283	90509150
Sternal fracture	40.05	11.90	32	118982	2855	90506578
Oropharyngeal spasm	39.89	11.90	15	118999	287	90509146
Manic symptom	39.74	11.90	11	119003	73	90509360
Sedation complication	39.62	11.90	76	118938	16868	90492565
Generalised tonic-clonic seizure	39.44	11.90	118	118896	34785	90474648
Dyslipidaemia	39.35	11.90	57	118957	10050	90499383
Neuropathy peripheral	39.31	11.90	75	118939	136895	90372538
Conversion disorder	39.11	11.90	28	118986	2118	90507315
Emotional poverty	39.04	11.90	16	118998	388	90509045
Pleural effusion	39.00	11.90	54	118960	111937	90397496
Antipsychotic drug level decreased	38.69	11.90	16	118998	397	90509036
Post cholecystectomy syndrome	38.16	11.90	20	118994	861	90508572
Bundle branch block right	37.71	11.90	41	118973	5412	90504021
Tachyphrenia	37.55	11.90	25	118989	1681	90507752
Hyperreflexia	37.48	11.90	45	118969	6612	90502821
Product administration interrupted	36.85	11.90	62	118952	12430	90497003
Pseudomyopia	36.85	11.90	10	119004	61	90509372
Eosinophilic myocarditis	36.83	11.90	18	118996	667	90508766
Pneumonia aspiration	36.82	11.90	128	118886	40812	90468621
Atrial fibrillation	36.76	11.90	75	118939	133536	90375897
Injection site reaction	36.70	11.90	40	118974	92040	90417393
Exostosis	36.67	11.90	12	119002	53122	90456311
Food craving	36.62	11.90	26	118988	1941	90507492
Fluid retention	36.53	11.90	37	118977	88054	90421379
Premature baby	36.50	11.90	93	118921	24984	90484449
Grandiosity	35.98	11.90	14	119000	295	90509138
Ideas of reference	35.86	11.90	11	119003	109	90509324
Polyuria	35.33	11.90	54	118960	9986	90499447
Breast feeding	35.29	11.90	19	118995	864	90508569
Vomiting	35.26	11.90	778	118236	787515	89721918
Neglect of personal appearance	35.08	11.90	11	119003	118	90509315
Sepsis	34.96	11.90	120	118894	179694	90329739
Negative symptoms in schizophrenia	34.91	11.90	11	119003	120	90509313
Delusion of reference	34.67	11.90	11	119003	123	90509310
Birdshot chorioretinopathy	34.50	11.90	10	119004	80	90509353
Normal newborn	34.38	11.90	87	118927	23275	90486158
Taste disorder	34.33	11.90	19	118995	61527	90447906
Vision blurred	34.13	11.90	255	118759	110038	90399395
Multiple organ dysfunction syndrome	34.11	11.90	24	118990	68312	90441121
Electroencephalogram abnormal	34.07	11.90	34	118980	4062	90505371
Cardiac failure congestive	33.96	11.90	48	118966	98646	90410787
Breech presentation	33.91	11.90	21	118993	1246	90508187
Megacolon	33.87	11.90	26	118988	2188	90507245
Premature labour	33.77	11.90	62	118952	13314	90496119
Vitamin B12 increased	33.68	11.90	24	118990	1802	90507631
Substance-induced psychotic disorder	33.58	11.90	29	118985	2883	90506550
Neuropsychiatric symptoms	33.49	11.90	17	118997	684	90508749
Acute kidney injury	33.34	11.90	265	118749	320122	90189311
Emotional distress	33.30	11.90	115	118899	36547	90472886
Gastrointestinal haemorrhage	32.97	11.90	42	118972	90206	90419227
Exposure during pregnancy	32.92	11.90	467	118547	237943	90271490
Oromandibular dystonia	32.89	11.90	16	118998	587	90508846
Rebound psychosis	32.85	11.90	12	119002	211	90509222
Ataxia	32.85	11.90	73	118941	17969	90491464
Bladder dilatation	32.82	11.90	19	118995	996	90508437
Coeliac disease	32.73	11.90	9	119005	44601	90464832
Reduced facial expression	32.68	11.90	27	118987	2526	90506907
Ascites	32.56	11.90	11	119003	47729	90461704
Hypoprolactinaemia	32.48	11.90	7	119007	12	90509421
Suspiciousness	32.45	11.90	14	119000	387	90509046
Substance use	32.41	11.90	20	118994	1179	90508254
Plasma cell myeloma	32.37	11.90	7	119007	40821	90468612
Morbid thoughts	32.32	11.90	17	118997	737	90508696
Hepatotoxicity	32.26	11.90	10	119004	45832	90463601
Neonatal hypotension	32.22	11.90	11	119003	157	90509276
Reversible cerebral vasoconstriction syndrome	32.02	11.90	33	118981	4097	90505336
Bone marrow oedema syndrome	31.85	11.90	9	119005	65	90509368
Product substitution issue	31.82	11.90	72	118942	17936	90491497
Skin ulcer	31.70	11.90	13	119001	50062	90459371
Type 2 diabetes mellitus	31.69	11.90	148	118866	203096	90306337
Head titubation	31.38	11.90	20	118994	1248	90508185
Back injury	31.35	11.90	11	119003	46611	90462822
Congenital eye disorder	31.32	11.90	8	119006	37	90509396
Inappropriate antidiuretic hormone secretion	31.20	11.90	75	118939	19430	90490003
Sexually inappropriate behaviour	31.18	11.90	10	119004	116	90509317
Target skin lesion	31.03	11.90	10	119004	118	90509315
Distractibility	30.99	11.90	15	118999	544	90508889
Nephrogenic diabetes insipidus	30.95	11.90	18	118996	952	90508481
Neoplasm progression	30.78	11.90	10	119004	44476	90464957
Delusion of parasitosis	30.65	11.90	10	119004	123	90509310
Onychomycosis	30.48	11.90	6	119008	37370	90472063
Walking aid user	30.47	11.90	5	119009	35501	90473932
Osteonecrosis of jaw	30.41	11.90	7	119007	39096	90470337
Congenital nystagmus	30.33	11.90	8	119006	43	90509390
Granulocyte count increased	30.24	11.90	21	118993	1513	90507920
Water intoxication	30.20	11.90	15	118999	576	90508857
Malaise	30.15	11.90	565	118449	585421	89924012
Productive cough	30.13	11.90	34	118980	77029	90432404
Personal relationship issue	30.08	11.90	10	119004	131	90509302
Emotional disorder	29.96	11.90	63	118951	14934	90494499
Eating disorder	29.93	11.90	93	118921	27980	90481453
Chorioretinopathy	29.86	11.90	17	118997	863	90508570
Physical assault	29.76	11.90	17	118997	869	90508564
Tension	29.60	11.90	30	118984	3652	90505781
Electrocardiogram QRS complex prolonged	29.43	11.90	42	118972	7306	90502127
Autonomic nervous system imbalance	29.37	11.90	29	118985	3421	90506012
Choroidal coloboma	29.30	11.90	7	119007	23	90509410
Dyspnoea exertional	29.25	11.90	31	118983	72257	90437176
Taciturnity	29.19	11.90	6	119008	7	90509426
Musculoskeletal stiffness	29.15	11.90	249	118765	296283	90213150
Nuchal rigidity	29.12	11.90	16	118998	758	90508675
Hypoventilation neonatal	29.07	11.90	7	119007	24	90509409
Hereditary ataxia	29.07	11.90	7	119007	24	90509409
Drug level above therapeutic	29.06	11.90	37	118977	5772	90503661
C-reactive protein increased	28.92	11.90	131	118883	181258	90328175
Compulsive hoarding	28.91	11.90	8	119006	53	90509380
Dysphoria	28.91	11.90	38	118976	6116	90503317
Concussion	28.75	11.90	52	118962	11039	90498394
Divorced	28.75	11.90	6	119008	8	90509425
Blood immunoglobulin A increased	28.72	11.90	19	118995	1264	90508169
Gastrooesophageal reflux disease	28.43	11.90	117	118897	166220	90343213
Frequent bowel movements	28.41	11.90	20	118994	56915	90452518
Dementia with Lewy bodies	28.31	11.90	13	119001	418	90509015
Diverticulitis	28.17	11.90	12	119002	45175	90464258
Gynaecomastia	28.09	11.90	11	119003	236	90509197
Agitation neonatal	28.08	11.90	14	119000	542	90508891
Congenital hypothyroidism	28	11.90	11	119003	238	90509195
Laryngitis	27.83	11.90	16	118998	50737	90458696
Hypertension	27.79	11.90	428	118586	457104	90052329
Dependent personality disorder	27.60	11.90	8	119006	64	90509369
Melaena	27.52	11.90	6	119008	34791	90474642
Uterine dilation and curettage	27.34	11.90	17	118997	1016	90508417
Macular degeneration	27.23	11.90	8	119006	37962	90471471
Psoriasis	27.13	11.90	101	118913	147653	90361780
Drug effective for unapproved indication	27.04	11.90	42	118972	7876	90501557
Hunger	27.00	11.90	38	118976	6525	90502908
Haematochezia	26.96	11.90	32	118982	70881	90438552
Septic shock	26.95	11.90	43	118971	84117	90425316
Aspartate aminotransferase	26.93	11.90	15	118999	730	90508703
Glomerular filtration rate increased	26.82	11.90	22	118992	2038	90507395
Persistent depressive disorder	26.66	11.90	18	118996	1239	90508194
Respiratory arrest	26.44	11.90	100	118914	33211	90476222
Disorganised speech	26.38	11.90	21	118993	1864	90507569
Chemical burn	26.11	11.90	13	119001	502	90508931
Granulocytopenia	26.07	11.90	37	118977	6404	90503029
Compulsions	26.05	11.90	10	119004	203	90509230
Electric shock	25.86	11.90	20	118994	1702	90507731
Neck pain	25.74	11.90	71	118943	113892	90395541
Accommodation disorder	25.68	11.90	12	119002	402	90509031
Homeless	25.67	11.90	8	119006	84	90509349
Fear	25.61	11.90	63	118951	16559	90492874
Breast enlargement	25.52	11.90	20	118994	1735	90507698
Hypertonic bladder	25.48	11.90	30	118984	4318	90505115
Sleep deficit	25.38	11.90	16	118998	980	90508453
Colitis ulcerative	25.35	11.90	25	118989	60241	90449192
Poor feeding infant	25.34	11.90	13	119001	535	90508898
Muscle tightness	25.17	11.90	55	118959	13384	90496049
Menstruation irregular	25.11	11.90	41	118973	8019	90501414
Glycosylated haemoglobin increased	25.07	11.90	60	118954	15502	90493931
Suspected suicide	24.98	11.90	45	118969	9523	90499910
Ear infection	24.94	11.90	33	118981	69742	90439691
Respiratory disorder	24.91	11.90	29	118985	64787	90444646
Poisoning	24.87	11.90	59	118955	15158	90494275
Laboratory test abnormal	24.71	11.90	12	119002	41842	90467591
Schizophreniform disorder	24.70	11.90	8	119006	96	90509337
Inability to afford medication	24.64	11.90	27	118987	3595	90505838
Hypothyroidism	24.57	11.90	136	118878	52991	90456442
Negativism	24.40	11.90	12	119002	451	90508982
White blood cells urine positive	24.36	11.90	36	118978	6462	90502971
Panic attack	24.20	11.90	83	118931	26282	90483151
Microphthalmos	24.19	11.90	9	119005	167	90509266
Facial nerve disorder	24.13	11.90	13	119001	592	90508841
Hypotonia	24.00	11.90	49	118965	11377	90498056
Negative thoughts	23.96	11.90	16	118998	1081	90508352
Verbal abuse	23.91	11.90	8	119006	107	90509326
Obsessive-compulsive symptom	23.91	11.90	8	119006	107	90509326
Postural tremor	23.85	11.90	12	119002	474	90508959
Staphylococcal infection	23.75	11.90	126	118888	48313	90461120
Drug-induced liver injury	23.75	11.90	52	118962	90266	90419167
Blood creatine phosphokinase	23.71	11.90	9	119005	177	90509256
Floppy iris syndrome	23.45	11.90	8	119006	114	90509319
Wound complication	23.29	11.90	30	118984	4733	90504700
Choroiditis	23.26	11.90	10	119004	274	90509159
Blood prolactin decreased	23.23	11.90	7	119007	65	90509368
Hypercalcaemia	23.16	11.90	8	119006	34232	90475201
Foetal growth restriction	23.08	11.90	43	118971	9337	90500096
Ear pain	23.06	11.90	25	118989	57677	90451756
Urinary bladder rupture	23.03	11.90	9	119005	192	90509241
Body mass index decreased	22.86	11.90	12	119002	518	90508915
White blood cell count increased	22.84	11.90	159	118855	67082	90442351
Retinal coloboma	22.79	11.90	6	119008	32	90509401
Oral candidiasis	22.77	11.90	9	119005	35446	90473987
Intentional product misuse	22.73	11.90	198	118816	89406	90420027
Pneumonitis	22.73	11.90	15	118999	44155	90465278
Suicide threat	22.63	11.90	6	119008	33	90509400
Drug tolerance decreased	22.62	11.90	7	119007	32123	90477310
Biliary tract infection	22.62	11.90	14	119000	830	90508603
Psychosexual disorder	22.55	11.90	4	119010	0	90509433
Shoplifting	22.55	11.90	4	119010	0	90509433
Confusional arousal	22.45	11.90	10	119004	299	90509134
COVID-19	22.35	11.90	130	118884	168713	90340720
Intermenstrual bleeding	22.34	11.90	42	118972	9181	90500252
Drug ineffective for unapproved indication	22.29	11.90	157	118857	66487	90442946
Inhibitory drug interaction	22.25	11.90	24	118990	3139	90506294
Myocarditis septic	22.19	11.90	6	119008	36	90509397
Breath odour	22.11	11.90	17	118997	1434	90507999
Paraesthesia oral	22.11	11.90	7	119007	31652	90477781
Social problem	21.97	11.90	16	118998	1243	90508190
Decreased interest	21.93	11.90	28	118986	4379	90505054
Rash pruritic	21.89	11.90	47	118967	82167	90427266
Delusional disorder, unspecified type	21.85	11.90	11	119003	435	90508998
Palmar-plantar erythrodysaesthesia syndrome	21.82	11.90	5	119009	28018	90481415
Merycism	21.79	11.90	10	119004	321	90509112
Intention tremor	21.78	11.90	11	119003	438	90508995
Death	21.70	11.90	446	118568	456105	90053328
International normalised ratio abnormal	21.66	11.90	26	118988	3819	90505614
Drug effect less than expected	21.58	11.90	33	118981	6105	90503328
Iris coloboma	21.52	11.90	6	119008	41	90509392
Urate nephropathy	21.47	11.90	8	119006	149	90509284
Muscular weakness	21.45	11.90	171	118843	206495	90302938
Pulmonary artery stenosis congenital	21.41	11.90	11	119003	454	90508979
Cholangitis infective	21.41	11.90	11	119003	454	90508979
Abortion threatened	21.41	11.90	12	119002	591	90508842
Obsessive thoughts	21.32	11.90	12	119002	596	90508837
Anterograde amnesia	21.30	11.90	12	119002	597	90508836
Polydipsia	21.24	11.90	27	118987	4204	90505229
Gastric ulcer	21.17	11.90	5	119009	27443	90481990
Myoglobin blood increased	21.10	11.90	17	118997	1535	90507898
Abnormal dreams	21.01	11.90	46	118968	11211	90498222
Hypocalcaemia	20.98	11.90	15	118999	42353	90467080
Cholestasis of pregnancy	20.86	11.90	17	118997	1560	90507873
Protrusion tongue	20.86	11.90	10	119004	355	90509078
Full blood count abnormal	20.85	11.90	11	119003	36586	90472847
Road traffic accident	20.79	11.90	72	118942	107554	90401879
Metastases to liver	20.79	11.90	6	119008	28801	90480632
Incontinence	20.78	11.90	51	118963	13384	90496049
Femur fracture	20.70	11.90	18	118996	46064	90463369
Hypernatraemia	20.60	11.90	41	118973	9346	90500087
Basal cell carcinoma	20.60	11.90	9	119005	33380	90476053
Transient aphasia	20.59	11.90	6	119008	49	90509384
Asocial behaviour	20.58	11.90	5	119009	18	90509415
Theft	20.56	11.90	7	119007	99	90509334
Screaming	20.54	11.90	25	118989	3725	90505708
Joint dislocation	20.53	11.90	17	118997	44565	90464868
Blood pressure systolic increased	20.44	11.90	28	118986	58317	90451116
Sleep-related eating disorder	20.40	11.90	14	119000	990	90508443
Affective ambivalence	20.37	11.90	5	119009	19	90509414
Poor quality sleep	20.32	11.90	75	118939	24618	90484815
Pancytopenia	20.30	11.90	85	118929	120178	90389255
Drowning	20.28	11.90	11	119003	508	90508925
Cataract	20.22	11.90	40	118974	72052	90437381
Cytomegalovirus infection	20.22	11.90	5	119009	26597	90482836
Tongue biting	20.18	11.90	19	118995	2114	90507319
Morning sickness	20.17	11.90	14	119000	1008	90508425
Fear of weight gain	20.16	11.90	5	119009	20	90509413
Diabetic hyperosmolar coma	20.09	11.90	10	119004	386	90509047
Auditory disorder	20.04	11.90	15	118999	1215	90508218
Rheumatoid factor increased	20.03	11.90	20	118994	2391	90507042
Full blood count decreased	19.97	11.90	7	119007	29682	90479751
Twin pregnancy	19.90	11.90	15	118999	1228	90508205
Therapy non-responder	19.88	11.90	102	118912	136602	90372831
Coloboma	19.83	11.90	7	119007	111	90509322
Injection site erythema	19.64	11.90	65	118949	98437	90410996
Lethargy	19.54	11.90	146	118868	62993	90446440
Bone pain	19.53	11.90	32	118982	61951	90447482
Sleep disorder due to a general medical condition	19.47	11.90	18	118996	44720	90464713
Akinesia	19.44	11.90	17	118997	1719	90507714
Female orgasmic disorder	19.42	11.90	6	119008	61	90509372
Pulmonary valve stenosis	19.35	11.90	10	119004	418	90509015
Middle insomnia	19.27	11.90	57	118957	16694	90492739
Back disorder	19.13	11.90	5	119009	25626	90483807
Oropharyngeal pain	19.08	11.90	82	118932	115105	90394328
Haemoptysis	19	11.90	10	119004	33310	90476123
Metastases to bone	18.99	11.90	5	119009	25500	90483933
Hemiparesis	18.97	11.90	9	119005	31810	90477623
Renal failure	18.91	11.90	98	118916	130909	90378524
Dyskinesia oesophageal	18.89	11.90	4	119010	6	90509427
Pregnancy with implant contraceptive	18.88	11.90	24	118990	3737	90505696
Pre-existing condition improved	18.88	11.90	39	118975	9130	90500303
Waxy flexibility	18.61	11.90	7	119007	134	90509299
Bradycardia	18.60	11.90	180	118834	83667	90425766
Deja vu	18.56	11.90	7	119007	135	90509298
Self-medication	18.51	11.90	22	118992	3198	90506235
Muscle contractions involuntary	18.50	11.90	21	118993	2907	90506526
Balance disorder	18.48	11.90	202	118812	96878	90412555
Nodule	18.46	11.90	6	119008	26680	90482753
Mental status changes	18.45	11.90	111	118903	44568	90464865
Meningitis streptococcal	18.42	11.90	7	119007	138	90509295
Adverse reaction	18.35	11.90	8	119006	29704	90479729
Decreased activity	18.24	11.90	36	118978	8156	90501277
Social anxiety disorder	18.24	11.90	11	119003	622	90508811
Haemoglobin decreased	18.23	11.90	131	118883	161825	90347608
Heart rate	18.12	11.90	8	119006	234	90509199
Ulcer haemorrhage	18.06	11.90	6	119008	26315	90483118
Activation syndrome	18.00	11.90	8	119006	238	90509195
Staring	17.99	11.90	16	118998	1654	90507779
Adjusted calcium increased	17.96	11.90	5	119009	34	90509399
Grimacing	17.91	11.90	10	119004	489	90508944
Dry mouth	17.87	11.90	155	118859	183904	90325529
Coronary artery disease	17.87	11.90	11	119003	33612	90475821
Haematuria	17.79	11.90	12	119002	34925	90474508
Feeling guilty	17.70	11.90	11	119003	657	90508776
Drug resistance	17.61	11.90	83	118931	30366	90479067
Polyhydramnios	17.59	11.90	19	118995	2489	90506944
Abdominal distension	17.58	11.90	100	118914	130501	90378932
Obstructive airways disorder	17.57	11.90	6	119008	25863	90483570
Hepatitis	17.57	11.90	42	118972	70697	90438736
Foetal anticonvulsant syndrome	17.56	11.90	11	119003	666	90508767
Chest discomfort	17.54	11.90	108	118906	138257	90371176
Ventricular septal defect	17.52	11.90	28	118986	5379	90504054
Rash erythematous	17.52	11.90	37	118977	65067	90444366
Neutrophilia	17.47	11.90	29	118985	5749	90503684
Cerebral haemorrhage	17.39	11.90	12	119002	34510	90474923
Neonatal respiratory distress	17.38	11.90	11	119003	678	90508755
Bronchiectasis	17.36	11.90	4	119010	22326	90487107
Fibrin D dimer increased	17.32	11.90	28	118986	5432	90504001
Cross sensitivity reaction	17.22	11.90	20	118994	2837	90506596
Food allergy	17.15	11.90	6	119008	25472	90483961
Narcolepsy	17.15	11.90	15	118999	1517	90507916
Cardiac arrest	17.15	11.90	212	118802	104723	90404710
Type 1 diabetes mellitus	17.10	11.90	26	118988	4786	90504647
Epistaxis	17.09	11.90	56	118958	85069	90424364
Joint hyperextension	16.99	11.90	9	119005	396	90509037
Congenital ureteric anomaly	16.95	11.90	6	119008	96	90509337
Right ventricular systolic pressure decreased	16.93	11.90	5	119009	43	90509390
Lisfranc fracture	16.91	11.90	3	119011	0	90509433
Noninfective encephalomyelitis	16.91	11.90	3	119011	0	90509433
Living alone	16.91	11.90	3	119011	0	90509433
Pyromania	16.91	11.90	3	119011	0	90509433
Schizoaffective disorder depressive type	16.91	11.90	3	119011	0	90509433
Muscle spasticity	16.85	11.90	13	119001	35309	90474124
Pseudodementia	16.83	11.90	6	119008	98	90509335
Injection site pruritus	16.77	11.90	28	118986	53806	90455627
Chills	16.74	11.90	103	118911	131878	90377555
Developmental hip dysplasia	16.71	11.90	15	118999	1570	90507863
Therapy change	16.67	11.90	35	118979	8287	90501146
Diabetic coma	16.64	11.90	11	119003	731	90508702
Somatic symptom disorder of pregnancy	16.35	11.90	6	119008	107	90509326
Helplessness	16.31	11.90	8	119006	299	90509134
Product quality issue	16.05	11.90	52	118962	79273	90430160
Violence-related symptom	16.03	11.90	10	119004	601	90508832
Blood glucose fluctuation	16.03	11.90	26	118988	5057	90504376
Angle closure glaucoma	16.02	11.90	19	118995	2756	90506677
Polyneuropathy	15.99	11.90	3	119011	19338	90490095
Trisomy 21	15.95	11.90	9	119005	449	90508984
Polydactyly	15.87	11.90	8	119006	317	90509116
Immature respiratory system	15.83	11.90	5	119009	55	90509378
Rhinorrhoea	15.80	11.90	61	118953	88255	90421178
Somatic symptom disorder	15.78	11.90	21	118993	3420	90506013
Electroconvulsive therapy	15.75	11.90	5	119009	56	90509377
Asphyxia	15.56	11.90	31	118983	7072	90502361
Respiratory tract infection	15.54	11.90	34	118980	59044	90450389
Tooth avulsion	15.51	11.90	5	119009	59	90509374
Creatinine renal clearance decreased	15.48	11.90	3	119011	18896	90490537
Body mass index increased	15.45	11.90	14	119000	1483	90507950
Feeling of despair	15.39	11.90	20	118994	3184	90506249
Patient dissatisfaction with treatment	15.31	11.90	8	119006	342	90509091
Acute myocardial infarction	15.22	11.90	14	119000	34876	90474557
Paroxysmal perceptual alteration	15.22	11.90	5	119009	63	90509370
Diabetic ketoacidosis	15.20	11.90	68	118946	24339	90485094
Bone marrow failure	15.20	11.90	12	119002	32209	90477224
Trichotillomania	15.18	11.90	6	119008	132	90509301
Sleep apnoea syndrome	15.17	11.90	82	118932	31665	90477768
Initial insomnia	15.11	11.90	36	118978	9274	90500159
Pustular psoriasis	15.09	11.90	3	119011	18553	90490880
Motor developmental delay	15.08	11.90	7	119007	231	90509202
Urine amphetamine positive	15.07	11.90	5	119009	65	90509368
Procedural pain	15.02	11.90	13	119001	33347	90476086
Weight decreased	14.97	11.90	382	118632	379528	90129905
Delusional perception	14.96	11.90	7	119007	235	90509198
Libido decreased	14.93	11.90	19	118995	2963	90506470
Muscle spasms	14.80	11.90	237	118777	251646	90257787
Hip fracture	14.76	11.90	13	119001	33064	90476369
Pupil fixed	14.71	11.90	16	118998	2112	90507321
Maternal exposure during breast feeding	14.67	11.90	28	118986	6192	90503241
Bone disorder	14.64	11.90	6	119008	23114	90486319
Genitourinary symptom	14.58	11.90	6	119008	147	90509286
Cell death	14.56	11.90	19	118995	3036	90506397
Irregular sleep phase	14.52	11.90	4	119010	26	90509407
Kleptomania	14.52	11.90	4	119010	26	90509407
Osteopenia	14.51	11.90	6	119008	22996	90486437
Pulmonary mass	14.49	11.90	10	119004	28762	90480671
Excessive eye blinking	14.49	11.90	13	119001	1359	90508074
Product administered by wrong person	14.48	11.90	5	119009	74	90509359
Memory impairment	14.41	11.90	350	118664	196894	90312539
CYP2C19 polymorphism	14.39	11.90	4	119010	27	90509406
Disruptive mood dysregulation disorder	14.37	11.90	3	119011	4	90509429
Bicytopenia	14.29	11.90	21	118993	3750	90505683
Crystalluria	14.25	11.90	9	119005	553	90508880
Delusion of grandeur	14.23	11.90	7	119007	263	90509170
Drug dependence	14.18	11.90	76	118938	29251	90480182
Myositis	14.12	11.90	7	119007	24121	90485312
Bacillus infection	14.10	11.90	11	119003	948	90508485
Acute hepatic failure	14.05	11.90	6	119008	22555	90486878
Female sexual dysfunction	14.01	11.90	5	119009	82	90509351
Throat clearing	13.97	11.90	21	118993	3826	90505607
Humidity intolerance	13.95	11.90	8	119006	412	90509021
Metastases to central nervous system	13.92	11.90	3	119011	17539	90491894
Dysbiosis	13.92	11.90	14	119000	1688	90507745
Temperature intolerance	13.90	11.90	41	118973	11989	90497444
Gastrointestinal lymphoma	13.90	11.90	5	119009	84	90509349
Pseudomembranous colitis	13.89	11.90	21	118993	3847	90505586
Bronchitis	13.88	11.90	131	118883	152796	90356637
Dactylitis	13.87	11.90	21	118993	3852	90505581
Paralogism	13.80	11.90	4	119010	32	90509401
Product dose omission issue	13.76	11.90	490	118524	291197	90218236
Migraine	13.71	11.90	172	118842	190220	90319213
Menstrual disorder	13.70	11.90	27	118987	6111	90503322
Cast application	13.69	11.90	4	119010	33	90509400
Gastritis	13.68	11.90	21	118993	41732	90467701
Induced labour	13.62	11.90	11	119003	997	90508436
Cardiac failure	13.60	11.90	86	118928	109410	90400023
Drug withdrawal syndrome neonatal	13.59	11.90	16	118998	2303	90507130
Hyponatriuria	13.59	11.90	4	119010	34	90509399
Poriomania	13.58	11.90	5	119009	90	90509343
Spasmodic dysphonia	13.53	11.90	5	119009	91	90509342
Embolism venous	13.49	11.90	20	118994	3600	90505833
Breast discharge	13.44	11.90	12	119002	1247	90508186
Sudden death	13.40	11.90	38	118976	10871	90498562
Arachnoid cyst	13.26	11.90	7	119007	306	90509127
Food refusal	13.24	11.90	9	119005	626	90508807
Head injury	13.21	11.90	78	118936	31110	90478323
Respiratory tract congestion	13.19	11.90	10	119004	27400	90482033
Convulsive threshold lowered	13.18	11.90	8	119006	458	90508975
High density lipoprotein increased	13.12	11.90	12	119002	1286	90508147
Glucose tolerance impaired	13.09	11.90	31	118983	7954	90501479
Radiculopathy	13.09	11.90	4	119010	18501	90490932
Hypotension	13.06	11.90	537	118477	324860	90184573
Sluggishness	13.05	11.90	26	118988	5933	90503500
Delirium	13.04	11.90	201	118813	104158	90405275
Hypersomnia-bulimia syndrome	13.02	11.90	3	119011	8	90509425
Gestational hypertension	13.00	11.90	18	118996	3044	90506389
Hypoxia	12.95	11.90	50	118964	72349	90437084
Perinatal depression	12.95	11.90	10	119004	849	90508584
Haematocrit increased	12.93	11.90	18	118996	3060	90506373
Drug screen positive	12.93	11.90	20	118994	3737	90505696
Polyarthritis	12.92	11.90	4	119010	18346	90491087
Localised infection	12.91	11.90	15	118999	33547	90475886
Nystagmus	12.89	11.90	29	118985	7198	90502235
Oral herpes	12.88	11.90	15	118999	33509	90475924
Foetal malnutrition	12.87	11.90	5	119009	105	90509328
Electrocardiogram PR prolongation	12.84	11.90	10	119004	860	90508573
Lung neoplasm malignant	12.82	11.90	8	119006	24265	90485168
Product administered at inappropriate site	12.78	11.90	21	118993	4130	90505303
Drug reaction with eosinophilia and systemic symptoms	12.74	11.90	98	118916	42660	90466773
Energy increased	12.70	11.90	18	118996	3112	90506321
Dry skin	12.64	11.90	66	118948	88007	90421426
Sinus disorder	12.61	11.90	16	118998	34431	90475002
Adrenal cyst	12.61	11.90	5	119009	111	90509322
Hypoglycaemia neonatal	12.59	11.90	11	119003	1111	90508322
Somatic hallucination	12.52	11.90	3	119011	10	90509423
Bulimia nervosa	12.46	11.90	8	119006	506	90508927
Large for dates baby	12.38	11.90	8	119006	511	90508922
Chronic sinusitis	12.36	11.90	8	119006	23794	90485639
Interstitial lung disease	12.28	11.90	55	118959	76350	90433083
Bacteraemia	12.27	11.90	7	119007	22293	90487140
Blood glucose decreased	12.21	11.90	62	118952	23367	90486066
Meningism	12.16	11.90	8	119006	527	90508906
Sexually transmitted disease	12.14	11.90	6	119008	228	90509205
Panic reaction	12.08	11.90	22	118992	4695	90504738
Plagiocephaly	12.02	11.90	5	119009	126	90509307
Bifascicular block	12.02	11.90	5	119009	126	90509307
Neurological examination normal	11.99	11.90	4	119010	53	90509380
Spinal fracture	11.99	11.90	7	119007	22009	90487424
Orthostatic hypotension	11.98	11.90	95	118919	41732	90467701
Irregular sleep wake rhythm disorder	11.95	11.90	6	119008	236	90509197
Drug metabolising enzyme decreased	11.91	11.90	3	119011	13	90509420

FDA Adverse Event Reporting System (Male)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Akathisia	1883.00	13.93	734	86796	9717	42524088
Neuroleptic malignant syndrome	1410.87	13.93	746	86784	20726	42513079
Extrapyramidal disorder	1259.24	13.93	633	86897	15779	42518026
Psychotic disorder	1255.60	13.93	769	86761	28439	42505366
Sedation	1011.74	13.93	682	86848	29793	42504012
Tardive dyskinesia	959.84	13.93	403	87127	6521	42527284
Dystonia	942.08	13.93	480	87050	12310	42521495
Hallucination, auditory	843.95	13.93	469	87061	14395	42519410
Weight increased	789.69	13.93	1038	86492	106945	42426860
Delusion	705.41	13.93	416	87114	14318	42519487
Suicide attempt	687.12	13.93	644	86886	45456	42488349
Parkinsonism	638.23	13.93	348	87182	10275	42523530
Gambling disorder	632.90	13.93	207	87323	1569	42532236
Treatment noncompliance	609.37	13.93	551	86979	37121	42496684
Suicidal ideation	600.17	13.93	610	86920	47551	42486254
Aggression	573.43	13.93	572	86958	43591	42490214
Dyskinesia	525.95	13.93	428	87102	24962	42508843
Product use in unapproved indication	519.40	13.93	1159	86371	183297	42350508
Schizophrenia	510.52	13.93	300	87230	10250	42523555
Psychotic symptom	455.50	13.93	175	87355	2215	42531590
Mania	450.98	13.93	277	87253	10270	42523535
Sexual dysfunction	407.06	13.93	222	87308	6553	42527252
Hyperprolactinaemia	406.57	13.93	156	87374	1967	42531838
Agitation	401.06	13.93	573	86957	63741	42470064
Obsessive-compulsive disorder	391.47	13.93	216	87314	6527	42527278
Salivary hypersecretion	384.73	13.93	254	87276	10689	42523116
Restlessness	359.65	13.93	368	87162	28881	42504924
Blood creatine phosphokinase increased	339.24	13.93	456	87074	47882	42485923
Febrile neutropenia	332.15	13.93	11	87519	185692	42348113
Irritability	331.60	13.93	346	87184	27782	42506023
Antipsychotic drug level below therapeutic	325.69	13.93	150	87380	3054	42530751
Catatonia	319.25	13.93	184	87346	6055	42527750
Disinhibition	309.60	13.93	154	87376	3741	42530064
Anaemia	294.93	13.93	104	87426	280174	42253631
Hypersexuality	293.82	13.93	116	87414	1586	42532219
Blood prolactin abnormal	285.42	13.93	100	87430	955	42532850
Dyspnoea	273.03	13.93	305	87225	442316	42091489
Muscle rigidity	272.47	13.93	214	87316	11845	42521960
Oculogyric crisis	269.09	13.93	110	87420	1655	42532150
Apathy	268.83	13.93	184	87346	8222	42525583
Increased appetite	268.51	13.93	188	87342	8718	42525087
Diarrhoea	263.58	13.93	337	87193	460512	42073293
Euphoric mood	244.49	13.93	157	87373	6296	42527509
Pneumonia	237.87	13.93	312	87218	421837	42111968
Emotional poverty	237.67	13.93	79	87451	633	42533172
Abnormal behaviour	237.07	13.93	282	87248	26169	42507636
Paranoia	236.17	13.93	210	87320	13816	42519989
Anxiety	232.68	13.93	650	86880	117910	42415895
Persecutory delusion	225.83	13.93	121	87409	3443	42530362
Therapeutic product effect variable	221.03	13.93	114	87416	2995	42530810
Obesity	216.77	13.93	215	87315	16244	42517561
Social avoidant behaviour	215.38	13.93	115	87415	3249	42530556
Underdose	212.67	13.93	214	87316	16452	42517353
Drug ineffective	212.49	13.93	2096	85434	628101	41905704
Serotonin syndrome	211.24	13.93	263	87267	25582	42508223
Priapism	201.94	13.93	139	87391	6268	42527537
Tremor	197.63	13.93	539	86991	96390	42437415
Anosognosia	197.35	13.93	76	87454	968	42532837
Intentional self-injury	197.28	13.93	197	87333	15005	42518800
Mental impairment	188.90	13.93	175	87355	12142	42521663
Foetal exposure during pregnancy	187.15	13.93	343	87187	46968	42486837
Malignant neoplasm progression	185.00	13.93	9	87521	108391	42425414
Somnolence	177.98	13.93	665	86865	140440	42393365
Psychomotor hyperactivity	176.45	13.93	160	87370	10798	42523007
Tic	174.09	13.93	89	87441	2294	42531511
Sedation complication	173.53	13.93	95	87435	2824	42530981
Schizoaffective disorder	168.82	13.93	82	87448	1888	42531917
Drug interaction	161.46	13.93	1018	86512	265981	42267824
Acute kidney injury	160.19	13.93	321	87209	367016	42166789
Prescribed overdose	159.47	13.93	163	87367	12764	42521041
Affective disorder	157.17	13.93	116	87414	5844	42527961
Disturbance in social behaviour	151.36	13.93	74	87456	1729	42532076
Sepsis	148.85	13.93	115	87415	199219	42334586
Metabolic disorder	148.83	13.93	103	87427	4685	42529120
Psychiatric decompensation	145.95	13.93	97	87433	4125	42529680
Compulsive shopping	145.34	13.93	49	87481	412	42533393
Depressed mood	145.07	13.93	208	87322	23176	42510629
Myocarditis	142.53	13.93	185	87345	18753	42515052
Psychiatric symptom	140.75	13.93	95	87435	4146	42529659
Cough	140.43	13.93	97	87433	178006	42355799
Homicidal ideation	139.21	13.93	81	87449	2713	42531092
Pyrexia	133.37	13.93	393	87137	393649	42140156
Electrocardiogram QT prolonged	132.93	13.93	300	87230	47645	42486160
Gambling	132.27	13.93	38	87492	174	42533631
Overdose	129.23	13.93	492	87038	104772	42429033
Delusional disorder, persecutory type	128.99	13.93	42	87488	313	42533492
Arthralgia	127.64	13.93	140	87390	205098	42328707
Insomnia	126.95	13.93	530	87000	117723	42416082
Torticollis	126.43	13.93	60	87470	1310	42532495
Pruritus	126.19	13.93	121	87409	188650	42345155
Thinking abnormal	126.10	13.93	110	87420	7051	42526754
Hypomania	125.73	13.93	73	87457	2435	42531370
Pain	125.58	13.93	193	87337	244655	42289150
Death	125.24	13.93	521	87009	470664	42063141
Blood prolactin increased	123.52	13.93	70	87460	2228	42531577
Hallucination	122.34	13.93	325	87205	57182	42476623
Bruxism	121.82	13.93	68	87462	2101	42531704
Antipsychotic drug level increased	121.21	13.93	90	87440	4576	42529229
Drooling	120.91	13.93	87	87443	4212	42529593
Asthenia	120.86	13.93	247	87283	280546	42253259
Disease progression	118.96	13.93	74	87456	143582	42390223
Compulsive sexual behaviour	117.79	13.93	37	87493	242	42533563
Delusion of grandeur	116.00	13.93	64	87466	1932	42531873
Atrial fibrillation	115.46	13.93	72	87458	139521	42394284
Loss of libido	114.58	13.93	74	87456	2996	42530809
Rhabdomyolysis	113.03	13.93	385	87145	77634	42456171
Refusal of treatment by patient	111.18	13.93	90	87440	5201	42528604
Pain in extremity	109.71	13.93	89	87441	150515	42383290
Infection	105.54	13.93	49	87481	112019	42421786
Hypotension	104.68	13.93	234	87296	257397	42276408
Anger	103.99	13.93	131	87399	12887	42520918
Intentional overdose	103.62	13.93	285	87245	51171	42482634
Oedema peripheral	102.15	13.93	78	87452	135998	42397807
General physical health deterioration	100.98	13.93	97	87433	151149	42382656
Libido increased	100.06	13.93	46	87484	932	42532873
Mental disorder	99.77	13.93	152	87378	17877	42515928
Pleural effusion	98.67	13.93	38	87492	97128	42436677
Interstitial lung disease	97.46	13.93	21	87509	78441	42455364
Renal failure	96.15	13.93	92	87438	143634	42390171
Hypoprolactinaemia	95.84	13.93	19	87511	3	42533802
Ascites	95.73	13.93	5	87525	56673	42477132
Cogwheel rigidity	94.49	13.93	54	87476	1747	42532058
Oppositional defiant disorder	88.39	13.93	36	87494	536	42533269
Rash	88.00	13.93	284	87246	276670	42257135
Septic shock	87.99	13.93	39	87491	91633	42442172
Back pain	87.76	13.93	97	87433	141679	42392126
Libido decreased	87.14	13.93	77	87453	5021	42528784
Gastrointestinal haemorrhage	85.60	13.93	47	87483	97679	42436126
Dystonic tremor	85.31	13.93	31	87499	332	42533473
Completed suicide	84.40	13.93	407	87123	96058	42437747
Abdominal pain	84.03	13.93	165	87365	190306	42343499
Antipsychotic drug level decreased	82.66	13.93	43	87487	1150	42532655
Trismus	82.56	13.93	59	87471	2825	42530980
Infusion related reaction	82.54	13.93	13	87517	60793	42473012
Tachycardia	81.70	13.93	417	87113	100670	42433135
Pancytopenia	81.54	13.93	73	87457	117670	42416135
Depression	81.53	13.93	447	87083	110916	42422889
Prescribed underdose	81.38	13.93	103	87427	10179	42523626
Plasma cell myeloma	80.98	13.93	4	87526	47574	42486231
Personality change	79.56	13.93	77	87453	5642	42528163
Joint swelling	78.98	13.93	21	87509	68001	42465804
Neutrophil count increased	77.53	13.93	143	87387	19661	42514144
Gynaecomastia	76.78	13.93	111	87419	12456	42521349
Drug abuse	76.32	13.93	420	87110	104351	42429454
Therapeutic product effect incomplete	75.31	13.93	317	87213	70622	42463183
Cardiac failure congestive	75.22	13.93	41	87489	85561	42448244
Economic problem	73.80	13.93	46	87484	1749	42532056
Hospitalisation	73.42	13.93	325	87205	74005	42459800
Rhinalgia	72.66	13.93	46	87484	1798	42532007
Drug dependence	71.81	13.93	174	87356	28920	42504885
Coronary artery disease	71.76	13.93	12	87518	53708	42480097
Product administered to patient of inappropriate age	71.75	13.93	67	87463	4694	42529111
Victim of child abuse	71.51	13.93	39	87491	1150	42532655
Drug monitoring procedure incorrectly performed	70.60	13.93	27	87503	337	42533468
Breech presentation	70.45	13.93	23	87507	173	42533632
Multiple organ dysfunction syndrome	69.81	13.93	58	87472	96977	42436828
Blood triglycerides increased	68.90	13.93	120	87410	15776	42518029
Epidural lipomatosis	68.68	13.93	44	87486	1756	42532049
Hyperkalaemia	68.58	13.93	40	87490	80418	42453387
Choreoathetosis	68.43	13.93	37	87493	1072	42532733
International normalised ratio increased	68.39	13.93	9	87521	48159	42485646
Impulsive behaviour	68.02	13.93	49	87481	2376	42531429
Leukopenia	68.00	13.93	319	87211	74427	42459378
Decreased eye contact	67.66	13.93	29	87501	494	42533311
Tongue movement disturbance	67.56	13.93	21	87509	132	42533673
Poor personal hygiene	67.17	13.93	26	87504	336	42533469
Dysarthria	66.23	13.93	206	87324	39601	42494204
Leukaemia	66.18	13.93	70	87460	5702	42528103
Disturbance in sexual arousal	65.63	13.93	21	87509	147	42533658
Delirium	65.63	13.93	247	87283	52272	42481533
Lymphocyte count abnormal	65.52	13.93	46	87484	2141	42531664
Nausea	65.01	13.93	513	87017	396286	42137519
Substance use	64.83	13.93	42	87488	1709	42532096
Self-injurious ideation	64.76	13.93	43	87487	1825	42531980
Haematochezia	64.23	13.93	20	87510	58416	42475389
Prostate cancer	64.21	13.93	8	87522	44635	42489170
Cardiac failure	64.04	13.93	75	87455	106781	42427024
Respiratory failure	63.68	13.93	103	87427	128029	42405776
Erythema	61.38	13.93	80	87450	108713	42425092
Myelosuppression	61.36	13.93	6	87524	40455	42493350
Renal impairment	61.22	13.93	82	87448	110146	42423659
Blepharospasm	61.20	13.93	37	87493	1331	42532474
Colitis	60.89	13.93	11	87519	46561	42487244
Paradoxical drug reaction	60.72	13.93	61	87469	4677	42529128
Thrombocytopenia	60.44	13.93	195	87335	190084	42343721
Dyslipidaemia	60.20	13.93	85	87445	9333	42524472
Blood prolactin decreased	60.10	13.93	22	87508	241	42533564
Rheumatoid arthritis	60.09	13.93	8	87522	42432	42491373
Psychosexual disorder	59.50	13.93	19	87511	132	42533673
Myocardial infarction	59.48	13.93	102	87428	123907	42409898
Inappropriate schedule of product administration	59.17	13.93	368	87162	95534	42438271
Hallucinations, mixed	58.94	13.93	52	87478	3383	42530422
Ventricular septal defect	58.90	13.93	58	87472	4341	42529464
Spasmodic dysphonia	58.03	13.93	26	87504	495	42533310
Hypothermia	57.56	13.93	97	87433	12418	42521387
Chills	57.47	13.93	65	87465	94001	42439804
Haemoglobin decreased	57.31	13.93	116	87414	132355	42401450
Affect lability	57.29	13.93	55	87475	3989	42529816
Drug hypersensitivity	57.19	13.93	72	87458	99317	42434488
Psychomotor retardation	57.04	13.93	57	87473	4342	42529463
Multiple drug therapy	56.96	13.93	33	87497	1096	42532709
Lactic acidosis	56.42	13.93	12	87518	45249	42488556
Urticaria	56.08	13.93	42	87488	73994	42459811
Stomatitis	55.72	13.93	17	87513	50312	42483493
Juvenile idiopathic arthritis	55.68	13.93	45	87485	2594	42531211
Antidepressant drug level above therapeutic	55.58	13.93	21	87509	253	42533552
Substance dependence	55.06	13.93	27	87503	635	42533170
Wheezing	54.65	13.93	22	87508	54759	42479046
Coma	54.26	13.93	236	87294	53318	42480487
Pneumonitis	54.23	13.93	10	87520	41708	42492097
Impulse-control disorder	53.99	13.93	36	87494	1539	42532266
Disturbance in attention	53.85	13.93	159	87371	29707	42504098
Muscle twitching	53.78	13.93	91	87439	11689	42522116
Dyspnoea exertional	53.63	13.93	18	87512	50130	42483675
Haematuria	53.27	13.93	26	87504	57773	42476032
Neurodegenerative disorder	53.12	13.93	23	87507	402	42533403
Infantile vomiting	52.98	13.93	16	87514	90	42533715
Child abuse	52.93	13.93	29	87501	863	42532942
Abdominal distension	52.68	13.93	42	87488	71693	42462112
Speech disorder	52.47	13.93	155	87375	28966	42504839
Seizure	52.40	13.93	425	87105	120136	42413669
Haemoptysis	52.19	13.93	15	87515	46152	42487653
Toxicity to various agents	52.11	13.93	708	86822	228428	42305377
Analgesic drug level above therapeutic	51.72	13.93	21	87509	310	42533495
Blood creatinine increased	51.36	13.93	92	87438	109911	42423894
Social anxiety disorder	51.25	13.93	25	87505	581	42533224
Keratoconus	50.84	13.93	17	87513	139	42533666
Autism spectrum disorder	50.80	13.93	45	87485	2943	42530862
Arthritis	50.73	13.93	12	87518	42053	42491752
Homosexuality	50.65	13.93	14	87516	54	42533751
Sinusitis	50.53	13.93	17	87513	47275	42486530
Chronic kidney disease	50.45	13.93	17	87513	47224	42486581
Musculoskeletal pain	50.41	13.93	5	87525	33335	42500470
Water intoxication	50.12	13.93	22	87508	398	42533407
Urinary tract infection	50.08	13.93	79	87451	99205	42434600
Mydriasis	50.02	13.93	75	87455	8695	42525110
Tension	49.85	13.93	41	87489	2423	42531382
Hypoxia	49.83	13.93	42	87488	69744	42464061
Sinus tachycardia	49.35	13.93	122	87408	20531	42513274
Sudden cardiac death	49.33	13.93	50	87480	3874	42529931
Hiccups	49.04	13.93	89	87441	12082	42521723
Hallucination, visual	49.00	13.93	123	87407	20897	42512908
Melaena	48.86	13.93	10	87520	38736	42495069
Fatigue	48.84	13.93	617	86913	435024	42098781
Bradyphrenia	48.61	13.93	57	87473	5205	42528600
Substance-induced psychotic disorder	48.11	13.93	43	87487	2846	42530959
Paroxysmal perceptual alteration	48.00	13.93	18	87512	212	42533593
Oromandibular dystonia	47.90	13.93	24	87506	592	42533213
Tongue biting	47.60	13.93	29	87501	1058	42532747
Crying	47.38	13.93	62	87468	6332	42527473
Headache	47.20	13.93	293	87237	239076	42294729
Homeless	46.85	13.93	11	87519	17	42533788
Anxiolytic therapy	46.46	13.93	13	87517	53	42533752
Galactorrhoea	46.24	13.93	22	87508	483	42533322
Rectal haemorrhage	46.19	13.93	22	87508	49584	42484221
Respiratory depression	45.66	13.93	112	87418	18756	42515049
Decreased appetite	45.40	13.93	223	87307	192914	42340891
Acute myocardial infarction	45.35	13.93	32	87498	58133	42475672
Paraphilia	45.32	13.93	14	87516	86	42533719
Mood altered	45.27	13.93	80	87450	10638	42523167
Neuropathy peripheral	45.06	13.93	88	87442	101765	42432040
Drug therapy enhancement	44.82	13.93	13	87517	62	42533743
Sexually inappropriate behaviour	44.73	13.93	23	87507	600	42533205
Metabolic syndrome	44.37	13.93	35	87495	1948	42531857
Hostility	44.33	13.93	25	87505	788	42533017
Wrong technique in product usage process	44.04	13.93	189	87341	42446	42491359
Acute psychosis	43.98	13.93	36	87494	2113	42531692
Upper respiratory tract infection	43.62	13.93	16	87514	42157	42491648
Intentional product misuse	43.61	13.93	246	87284	61654	42472151
Antipsychotic drug level above therapeutic	43.17	13.93	29	87501	1255	42532550
Cerebrovascular accident	42.94	13.93	84	87446	97076	42436729
Loss of employment	42.82	13.93	21	87509	494	42533311
Withdrawal syndrome	42.66	13.93	94	87436	14681	42519124
Physical assault	42.66	13.93	27	87503	1055	42532750
Bronchitis	42.34	13.93	22	87508	47179	42486626
Bradykinesia	42.30	13.93	54	87476	5382	42528423
Bipolar disorder	42.21	13.93	46	87484	3876	42529929
Hyperthermia	42.11	13.93	85	87445	12489	42521316
Heat stroke	42.07	13.93	27	87503	1081	42532724
Exhibitionism	41.94	13.93	12	87518	54	42533751
Male sexual dysfunction	41.87	13.93	19	87511	373	42533432
Social problem	41.76	13.93	28	87502	1208	42532597
Dependence	41.73	13.93	30	87500	1450	42532355
Sudden death	41.62	13.93	100	87430	16529	42517276
Exposure via breast milk	41.51	13.93	37	87493	2440	42531365
Hypokalaemia	41.20	13.93	52	87478	71669	42462136
Imprisonment	41.18	13.93	22	87508	622	42533183
Thrombosis	41.13	13.93	48	87482	68463	42465342
Peripheral swelling	40.80	13.93	77	87453	90193	42443612
Erectile dysfunction	40.58	13.93	128	87402	24785	42509020
Product availability issue	40.44	13.93	43	87487	3524	42530281
Diabetic ketoacidosis	40.24	13.93	119	87411	22248	42511557
Foetal disorder	40.24	13.93	26	87504	1053	42532752
Haemorrhage	40.19	13.93	39	87491	60524	42473281
Hyperreflexia	40.04	13.93	43	87487	3564	42530241
Fall	39.80	13.93	300	87230	234220	42299585
Therapy change	38.90	13.93	45	87485	4050	42529755
Epistaxis	38.86	13.93	48	87482	66778	42467027
Oscillopsia	38.76	13.93	16	87514	247	42533558
Bankruptcy	38.69	13.93	9	87521	13	42533792
Premature baby	38.67	13.93	120	87410	23033	42510772
Blunted affect	38.52	13.93	18	87512	379	42533426
Electrocardiogram QT shortened	38.44	13.93	14	87516	151	42533654
Anaphylactic reaction	38.22	13.93	20	87510	42723	42491082
Obsessive thoughts	37.85	13.93	23	87507	835	42532970
Pleurothotonus	37.51	13.93	26	87504	1185	42532620
Posture abnormal	37.07	13.93	35	87495	2486	42531319
Symptom recurrence	37.05	13.93	28	87502	1462	42532343
Productive cough	36.85	13.93	31	87499	51536	42482269
Type 2 diabetes mellitus	36.85	13.93	102	87428	18369	42515436
Cerebral haemorrhage	36.71	13.93	17	87513	38949	42494856
Neglect of personal appearance	36.60	13.93	17	87513	353	42533452
Cholestasis	36.58	13.93	11	87519	32868	42500937
Feeling guilty	36.42	13.93	17	87513	357	42533448
Enuresis	36.36	13.93	36	87494	2712	42531093
Hypervolaemia	36.22	13.93	3	87527	23122	42510683
Sopor	35.88	13.93	82	87448	13120	42520685
Gout	35.88	13.93	7	87523	28048	42505757
Haematoma	35.82	13.93	7	87523	28016	42505789
Head titubation	35.67	13.93	18	87512	451	42533354
Dysgeusia	35.31	13.93	13	87517	34176	42499629
Gaze palsy	35.03	13.93	30	87500	1875	42531930
Incorrect dose administered	35.01	13.93	207	87323	52767	42481038
Chronic obstructive pulmonary disease	34.98	13.93	47	87483	63067	42470738
Staphylococcal infection	34.58	13.93	17	87513	37626	42496179
Hallucination, tactile	34.57	13.93	19	87511	569	42533236
Swelling	34.53	13.93	37	87493	54848	42478957
Poisoning deliberate	34.53	13.93	69	87461	10065	42523740
Postictal psychosis	34.46	13.93	14	87516	207	42533598
Cardiogenic shock	34.44	13.93	15	87515	35625	42498180
Altered state of consciousness	34.40	13.93	135	87395	29124	42504681
Activation syndrome	34.38	13.93	13	87517	157	42533648
Hyperphagia	34.23	13.93	28	87502	1642	42532163
Troponin T increased	34.18	13.93	35	87495	2745	42531060
Mycobacterial peritonitis	34.15	13.93	13	87517	160	42533645
Upper gastrointestinal haemorrhage	33.96	13.93	10	87520	30289	42503516
Neutropenia neonatal	33.90	13.93	22	87508	898	42532907
Granulocytopenia	33.87	13.93	56	87474	7058	42526747
Insurance issue	33.79	13.93	42	87488	4074	42529731
Influenza	33.75	13.93	47	87483	62128	42471677
Neuralgia	33.65	13.93	6	87524	25641	42508164
Product prescribing error	33.60	13.93	124	87406	25988	42507817
Abdominal pain upper	33.48	13.93	75	87455	82534	42451271
Pseudomyopia	33.44	13.93	11	87519	85	42533720
Musculoskeletal stiffness	33.34	13.93	218	87312	57547	42476258
Urinary incontinence	33.17	13.93	109	87421	21559	42512246
Myelodysplastic syndrome	32.89	13.93	4	87526	22741	42511064
Rash maculo-papular	32.87	13.93	18	87512	37485	42496320
Negative symptoms in schizophrenia	32.47	13.93	11	87519	94	42533711
Polydipsia	32.45	13.93	43	87487	4445	42529360
Dry skin	32.22	13.93	31	87499	48307	42485498
Herpes zoster	32.18	13.93	20	87510	38857	42494948
Depressed level of consciousness	32.05	13.93	188	87342	47782	42486023
Pneumothorax	32.02	13.93	5	87525	23538	42510267
Feeling abnormal	31.93	13.93	249	87281	69537	42464268
Sleep disorder	31.82	13.93	188	87342	47907	42485898
Somatic hallucination	31.73	13.93	9	87521	39	42533766
Mycobacterium fortuitum infection	31.70	13.93	16	87514	401	42533404
Nicotine dependence	31.66	13.93	19	87511	674	42533131
Off label use	31.47	13.93	1606	85924	636729	41897076
Muscle contractions involuntary	31.37	13.93	29	87501	2005	42531800
Staring	31.31	13.93	26	87504	1557	42532248
Diabetes mellitus	31.24	13.93	221	87309	59866	42473939
Accidental death	31.18	13.93	35	87495	3048	42530757
Schizophreniform disorder	31.01	13.93	10	87520	72	42533733
COVID-19 pneumonia	30.77	13.93	4	87526	21609	42512196
Soliloquy	30.71	13.93	18	87512	611	42533194
Stereotypy	30.69	13.93	20	87510	822	42532983
Basilar artery occlusion	30.43	13.93	10	87520	77	42533728
Patient restraint	30.43	13.93	10	87520	77	42533728
Frequent bowel movements	30.38	13.93	4	87526	21403	42512402
Nervousness	30.30	13.93	78	87452	13454	42520351
Weight decreased	30.27	13.93	277	87253	207671	42326134
Clostridium difficile colitis	30.09	13.93	4	87526	21248	42512557
Abdominal discomfort	29.95	13.93	69	87461	75186	42458619
Dopamine dysregulation syndrome	29.58	13.93	17	87513	556	42533249
Delusional disorder, unspecified type	29.57	13.93	19	87511	762	42533043
Skin ulcer	29.53	13.93	8	87522	25593	42508212
Hypophosphataemia	29.52	13.93	4	87526	20941	42512864
Poor quality sleep	29.48	13.93	62	87468	9378	42524427
Lung disorder	29.38	13.93	33	87497	47890	42485915
Coordination abnormal	28.86	13.93	56	87474	7994	42525811
Foetal distress syndrome	28.86	13.93	22	87508	1164	42532641
Therapy cessation	28.77	13.93	100	87430	20350	42513455
Colitis ulcerative	28.68	13.93	9	87521	26166	42507639
Bacteraemia	28.55	13.93	8	87522	25032	42508773
Oedema	28.53	13.93	39	87491	51962	42481843
Intentional product use issue	28.47	13.93	66	87464	71767	42462038
Negative thoughts	28.42	13.93	18	87512	704	42533101
Emotional distress	28.36	13.93	85	87445	16008	42517797
COVID-19	28.31	13.93	132	87398	115816	42417989
Blood pressure systolic increased	28.27	13.93	11	87519	27957	42505848
Hunger	28.09	13.93	27	87503	1961	42531844
Antisocial behaviour	28.08	13.93	15	87515	424	42533381
Reversible cerebral vasoconstriction syndrome	28.02	13.93	18	87512	722	42533083
Arthropathy	27.75	13.93	13	87517	29584	42504221
Compulsive hoarding	27.74	13.93	7	87523	17	42533788
Maternal exposure during breast feeding	27.60	13.93	24	87506	1531	42532274
Mood swings	27.60	13.93	58	87472	8768	42525037
Restless legs syndrome	27.56	13.93	61	87469	9553	42524252
Sleep-related eating disorder	27.48	13.93	14	87516	358	42533447
Muscle contracture	27.21	13.93	23	87507	1412	42532393
Dysphoria	27.16	13.93	31	87499	2749	42531056
Tachyphrenia	27.15	13.93	23	87507	1416	42532389
Subdural haematoma	27.12	13.93	7	87523	23131	42510674
Pulmonary valve incompetence	27.04	13.93	21	87509	1142	42532663
Self-destructive behaviour	27.03	13.93	14	87516	371	42533434
Rash pruritic	26.84	13.93	18	87512	33585	42500220
Accommodation disorder	26.73	13.93	13	87517	300	42533505
Nasopharyngitis	26.68	13.93	86	87444	83910	42449895
Drug withdrawal syndrome neonatal	26.66	13.93	39	87491	4422	42529383
Electrocardiogram QRS complex prolonged	26.60	13.93	45	87485	5778	42528027
Full blood count decreased	26.56	13.93	5	87525	20555	42513250
Inability to afford medication	26.52	13.93	27	87503	2103	42531702
Compulsions	26.52	13.93	12	87518	234	42533571
Emotional disorder	26.50	13.93	47	87483	6267	42527538
Movement disorder	26.25	13.93	78	87452	14620	42519185
Hypoglycaemia	26.21	13.93	52	87478	59802	42474003
Psoriasis	26.12	13.93	37	87493	48567	42485238
Drug effective for unapproved indication	26.09	13.93	48	87482	6585	42527220
Suicidal behaviour	25.72	13.93	23	87507	1523	42532282
Ventricular fibrillation	25.62	13.93	15	87515	30108	42503697
Stupor	25.61	13.93	32	87498	3121	42530684
Rebound psychosis	25.42	13.93	11	87519	192	42533613
Hypokinesia	25.39	13.93	60	87470	9811	42523994
Dementia	25.32	13.93	83	87447	16397	42517408
Nephrolithiasis	25.27	13.93	23	87507	36807	42496998
Non-high-density lipoprotein cholesterol increased	25.26	13.93	11	87519	195	42533610
Fluid retention	25.17	13.93	17	87513	31602	42502203
Alcohol abuse	25.08	13.93	36	87494	4013	42529792
Hyperkinesia	25.05	13.93	26	87504	2072	42531733
Eye movement disorder	25.00	13.93	40	87490	4905	42528900
Depressive symptom	24.96	13.93	35	87495	3818	42529987
Blood cholesterol increased	24.94	13.93	115	87415	26626	42507179
Malignant catatonia	24.72	13.93	14	87516	445	42533360
Diverticulitis	24.65	13.93	8	87522	22765	42511040
Bladder cancer	24.64	13.93	3	87527	17044	42516761
Faeces discoloured	24.58	13.93	3	87527	17011	42516794
Hypomagnesaemia	24.50	13.93	14	87516	28474	42505331
Candida infection	24.46	13.93	7	87523	21603	42512202
Transient ischaemic attack	24.45	13.93	20	87510	33719	42500086
Skin exfoliation	23.99	13.93	30	87500	41523	42492282
Eosinophil count decreased	23.94	13.93	33	87497	3543	42530262
Reduced facial expression	23.92	13.93	22	87508	1511	42532294
Dehydration	23.71	13.93	182	87348	141585	42392220
Encephalopathy	23.70	13.93	30	87500	41303	42492502
Rebound effect	23.67	13.93	49	87481	7330	42526475
Cataract	23.63	13.93	17	87513	30587	42503218
Theft	23.61	13.93	11	87519	230	42533575
Cognitive disorder	23.53	13.93	135	87395	34037	42499768
Hyperaldosteronism	23.52	13.93	11	87519	232	42533573
Hypometabolism	23.40	13.93	10	87520	169	42533636
Asthma	23.32	13.93	59	87471	62255	42471550
Hypoacusis	23.22	13.93	5	87525	18697	42515108
Megacolon	23.21	13.93	26	87504	2259	42531546
Product substitution issue	23.17	13.93	63	87467	11227	42522578
Diabetic coma	23.11	13.93	18	87512	983	42532822
Pulmonary fibrosis	23.10	13.93	13	87517	26668	42507137
Fungal infection	23.05	13.93	6	87524	19716	42514089
Excessive masturbation	22.93	13.93	9	87521	121	42533684
Iatrogenic injury	22.88	13.93	17	87513	865	42532940
Oxygen saturation decreased	22.87	13.93	63	87467	64624	42469181
Blood thyroid stimulating hormone decreased	22.86	13.93	26	87504	2297	42531508
Behaviour disorder	22.81	13.93	47	87483	7007	42526798
Anaphylactic shock	22.56	13.93	10	87520	23507	42510298
Gastrooesophageal reflux disease	22.52	13.93	36	87494	44987	42488818
Activated partial thromboplastin time prolonged	22.50	13.93	3	87527	15900	42517905
Skin lesion	22.46	13.93	14	87516	27160	42506645
Flat affect	22.40	13.93	18	87512	1029	42532776
Lethargy	22.38	13.93	169	87361	46721	42487084
Ejaculation disorder	22.38	13.93	18	87512	1030	42532775
High-grade B-cell lymphoma	22.38	13.93	10	87520	189	42533616
Moaning	22.26	13.93	17	87513	902	42532903
Bacterial infection	22.17	13.93	15	87515	27864	42505941
Pneumonia bacterial	22.11	13.93	3	87527	15689	42518116
Red cell distribution width decreased	21.78	13.93	11	87519	276	42533529
Adrenal insufficiency	21.66	13.93	6	87524	18918	42514887
Gangrene neonatal	21.64	13.93	10	87520	205	42533600
Accidental exposure to product by child	21.61	13.93	21	87509	1546	42532259
Gaming disorder	21.59	13.93	5	87525	7	42533798
Nephrogenic diabetes insipidus	21.53	13.93	21	87509	1553	42532252
Tubulointerstitial nephritis	21.29	13.93	20	87510	31528	42502277
Angioedema	21.21	13.93	34	87496	42443	42491362
Urinary retention	21.20	13.93	154	87376	42060	42491745
Polyneuropathy	21.20	13.93	6	87524	18655	42515150
Blood glucose increased	21.13	13.93	238	87292	73461	42460344
Pyramidal tract syndrome	21.12	13.93	11	87519	295	42533510
Flushing	21.10	13.93	27	87503	37001	42496804
Slow speech	21.04	13.93	22	87508	1768	42532037
SARS-CoV-2 test positive	21.02	13.93	50	87480	8210	42525595
Appendicitis	21.01	13.93	8	87522	20605	42513200
Muscular weakness	21.00	13.93	94	87436	83404	42450401
Mutism	20.93	13.93	20	87510	1442	42532363
Obsessive-compulsive symptom	20.92	13.93	10	87520	222	42533583
Disorientation	20.79	13.93	137	87393	36252	42497553
Hepatotoxicity	20.75	13.93	13	87517	25154	42508651
Energy increased	20.64	13.93	20	87510	1467	42532338
Substance abuse	20.64	13.93	52	87478	8853	42524952
Anamnestic reaction	20.54	13.93	7	87523	61	42533744
Metastases to bone	20.47	13.93	3	87527	14806	42518999
Thrombotic microangiopathy	20.42	13.93	3	87527	14779	42519026
Neutropenic sepsis	20.34	13.93	4	87526	15942	42517863
Impaired healing	20.29	13.93	5	87525	17048	42516757
Myalgia	20.27	13.93	115	87415	95965	42437840
Substance use disorder	20.17	13.93	38	87492	5307	42528498
Benign prostatic hyperplasia	20.12	13.93	9	87521	21043	42512762
Inappropriate antidiuretic hormone secretion	19.99	13.93	77	87453	16464	42517341
Dysphemia	19.94	13.93	22	87508	1880	42531925
Vomiting	19.43	13.93	450	87080	289273	42244532
Hypertonia	19.43	13.93	36	87494	4965	42528840
Adverse event	19.40	13.93	98	87432	23542	42510263
Skin turgor decreased	19.37	13.93	13	87517	562	42533243
Pneumonia aspiration	19.33	13.93	172	87358	49906	42483899
Eczema	19.27	13.93	25	87505	34061	42499744
Anorgasmia	19.09	13.93	17	87513	1120	42532685
Nephrectasia	19.05	13.93	5	87525	15	42533790
Orthostatic hypertension	18.93	13.93	12	87518	470	42533335
Ornithine transcarbamoylase deficiency	18.81	13.93	5	87525	16	42533789
Obstructive airways disorder	18.80	13.93	14	87516	24745	42509060
Rash erythematous	18.70	13.93	23	87507	32068	42501737
Osteomyelitis	18.69	13.93	7	87523	18216	42515589
Bone pain	18.66	13.93	13	87517	23779	42510026
Gender dysphoria	18.63	13.93	6	87524	43	42533762
Sinus arrhythmia	18.60	13.93	15	87515	862	42532943
Lung neoplasm malignant	18.59	13.93	8	87522	19139	42514666
Pulmonary hypertension	18.32	13.93	13	87517	23556	42510249
Paraesthesia	18.29	13.93	83	87447	73376	42460429
Erection increased	18.29	13.93	12	87518	499	42533306
Clostridium difficile infection	18.28	13.93	12	87518	22647	42511158
Autonomic nervous system imbalance	18.27	13.93	27	87503	3089	42530716
Chest discomfort	18.27	13.93	68	87462	63548	42470257
Type 1 diabetes mellitus	18.26	13.93	37	87493	5450	42528355
Blood pressure fluctuation	18.23	13.93	17	87513	26891	42506914
Ejaculation delayed	18.21	13.93	10	87520	299	42533506
Pericardial effusion	18.12	13.93	20	87510	29255	42504550
Antidepressant drug level increased	17.92	13.93	9	87521	223	42533582
Grandiosity	17.88	13.93	10	87520	310	42533495
Rhesus incompatibility	17.84	13.93	6	87524	50	42533755
Screaming	17.83	13.93	21	87509	1926	42531879
Suicide threat	17.74	13.93	6	87524	51	42533754
Suspiciousness	17.65	13.93	11	87519	418	42533387
Negativism	17.61	13.93	11	87519	420	42533385
End stage renal disease	17.60	13.93	6	87524	16552	42517253
Blood urea increased	17.58	13.93	25	87505	32768	42501037
Proteinuria	17.44	13.93	13	87517	22970	42510835
Alcohol use disorder	17.44	13.93	6	87524	54	42533751
Oligospermia	17.39	13.93	7	87523	101	42533704
Panic attack	17.30	13.93	56	87474	10989	42522816
Weight decrease neonatal	17.29	13.93	10	87520	331	42533474
Acute myopia	17.21	13.93	5	87525	24	42533781
Diarrhoea infectious	17.20	13.93	13	87517	679	42533126
Cloacal exstrophy	17.15	13.93	6	87524	57	42533748
Cholecystitis	17.12	13.93	3	87527	12985	42520820
Squamous cell carcinoma	17.11	13.93	3	87527	12979	42520826
Atrial flutter	17.08	13.93	7	87523	17244	42516561
Haemorrhage intracranial	16.98	13.93	7	87523	17185	42516620
Meconium aspiration syndrome	16.97	13.93	6	87524	59	42533746
Aorta hypoplasia	16.96	13.93	7	87523	108	42533697
Flatulence	16.91	13.93	16	87514	25136	42508669
Underweight	16.85	13.93	13	87517	700	42533105
Bipolar I disorder	16.78	13.93	14	87516	844	42532961
Neuroleptic-induced deficit syndrome	16.73	13.93	5	87525	27	42533778
Cholelithiasis	16.72	13.93	14	87516	23332	42510473
Libido disorder	16.71	13.93	10	87520	353	42533452
Platelet count decreased	16.69	13.93	193	87337	138388	42395417
Delusional perception	16.68	13.93	8	87522	179	42533626
Coma scale abnormal	16.66	13.93	32	87498	4533	42529272
Skin disorder	16.58	13.93	7	87523	16937	42516868
Renal hypertension	16.58	13.93	9	87521	263	42533542
Hyperbilirubinaemia	16.55	13.93	11	87519	20624	42513181
Hepatic cirrhosis	16.49	13.93	10	87520	19692	42514113
Myopathy	16.44	13.93	4	87526	13757	42520048
Osteonecrosis	16.43	13.93	6	87524	15859	42517946
Tonic posturing	16.28	13.93	5	87525	30	42533775
Hyperammonaemia	16.25	13.93	44	87486	7822	42525983
Grimacing	16.24	13.93	10	87520	372	42533433
Blood ketone body	16.19	13.93	7	87523	122	42533683
Chest pain	16.16	13.93	196	87334	139334	42394471
Aplastic anaemia	16.02	13.93	3	87527	12381	42521424
Hypersomnia	16.02	13.93	66	87464	14552	42519253
Logorrhoea	16.00	13.93	24	87506	2783	42531022
Dermatillomania	15.98	13.93	6	87524	71	42533734
Atelectasis	15.96	13.93	10	87520	19351	42514454
Hip fracture	15.93	13.93	4	87526	13468	42520337
Hypoaesthesia	15.91	13.93	84	87446	71379	42462426
Osteoarthritis	15.86	13.93	16	87514	24389	42509416
Duodenal ulcer	15.83	13.93	3	87527	12276	42521529
Divorced	15.77	13.93	4	87526	10	42533795
Selective mutism	15.75	13.93	6	87524	74	42533731
Anterograde amnesia	15.75	13.93	9	87521	291	42533514
Heart rate increased	15.72	13.93	173	87357	53082	42480723
Foetal growth restriction	15.69	13.93	34	87496	5249	42528556
Gastric ulcer	15.66	13.93	9	87521	18253	42515552
Troponin increased	15.62	13.93	79	87451	18983	42514822
Hyperhidrosis	15.61	13.93	267	87263	90245	42443560
Hyperthyroidism	15.59	13.93	5	87525	14336	42519469
Complicated fracture	15.57	13.93	3	87527	0	42533805
Lymphoma	15.55	13.93	5	87525	14316	42519489
Food craving	15.52	13.93	11	87519	520	42533285
Glabellar reflex abnormal	15.50	13.93	5	87525	36	42533769
Product reconstitution quality issue	15.41	13.93	8	87522	213	42533592
Rabbit syndrome	15.39	13.93	5	87525	37	42533768
Rhinorrhoea	15.36	13.93	26	87504	31768	42502037
Bicuspid aortic valve	15.32	13.93	9	87521	307	42533498
Hypocalcaemia	15.21	13.93	24	87506	30149	42503656
Congestive cardiomyopathy	15.17	13.93	46	87484	8718	42525087
Acute respiratory failure	15.16	13.93	36	87494	38822	42494983
Floppy iris syndrome	15.11	13.93	9	87521	315	42533490
Hepatic failure	15.10	13.93	35	87495	38065	42495740
Sluggishness	15.08	13.93	28	87502	3868	42529937
High density lipoprotein decreased	15.07	13.93	28	87502	3869	42529936
Urosepsis	15.03	13.93	6	87524	15014	42518791
Excessive sexual fantasies	15	13.93	4	87526	13	42533792
Dysphagia	14.99	13.93	221	87309	72498	42461307
Ejaculation failure	14.97	13.93	13	87517	828	42532977
Parkinsonian rest tremor	14.93	13.93	9	87521	322	42533483
Binge eating	14.91	13.93	7	87523	149	42533656
Angina pectoris	14.91	13.93	28	87502	32868	42500937
Psychomotor skills impaired	14.90	13.93	33	87497	5171	42528634
Glycogen storage disorder	14.77	13.93	4	87526	14	42533791
Toxic epidermal necrolysis	14.73	13.93	20	87510	26730	42507075
Mucosal inflammation	14.69	13.93	52	87478	49322	42484483
Neoplasm malignant	14.68	13.93	15	87515	22728	42511077
Food interaction	14.67	13.93	14	87516	1008	42532797
Regurgitation	14.67	13.93	19	87511	1921	42531884
Cardiomyopathy	14.63	13.93	78	87452	19132	42514673
Electrocardiogram abnormal	14.61	13.93	50	87480	10095	42523710
Prader-Willi syndrome	14.56	13.93	4	87526	15	42533790
Blood insulin abnormal	14.56	13.93	4	87526	15	42533790
Flight of ideas	14.51	13.93	9	87521	339	42533466
Vasculitis	14.49	13.93	10	87520	18384	42515421
Intrusive thoughts	14.42	13.93	10	87520	456	42533349
Jaundice neonatal	14.42	13.93	20	87510	2159	42531646
Hypoalbuminaemia	14.41	13.93	7	87523	15603	42518202
Therapy partial responder	14.38	13.93	80	87450	19941	42513864
Delusion of reference	14.34	13.93	6	87524	96	42533709
Haematemesis	14.31	13.93	25	87505	30174	42503631
Nodule	14.30	13.93	4	87526	12530	42521275
Hypospadias	14.26	13.93	26	87504	3541	42530264
Wolff-Parkinson-White syndrome	14.25	13.93	8	87522	250	42533555
Malnutrition	14.24	13.93	6	87524	14536	42519269
Atrioventricular block complete	14.19	13.93	3	87527	11361	42522444
Impaired self-care	14.18	13.93	15	87515	1222	42532583
CADASIL	14.17	13.93	6	87524	99	42533706
Benign ethnic neutropenia	14.17	13.93	6	87524	99	42533706
Inappropriate affect	14.09	13.93	12	87518	744	42533061
Major depression	14.09	13.93	33	87497	5365	42528440
Disorganised speech	14.08	13.93	16	87514	1412	42532393
Ataxia	14.05	13.93	68	87462	16057	42517748
Contusion	14.03	13.93	42	87488	41943	42491862
Troponin I increased	13.96	13.93	24	87506	3122	42530683

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Akathisia	3239.01	12.53	1151	167224	15962	110404962
Extrapyramidal disorder	2619.04	12.53	1140	167235	27727	110393197
Dystonia	2291.83	12.53	1004	167371	24801	110396123
Tardive dyskinesia	2194.75	12.53	813	167562	12766	110408158
Neuroleptic malignant syndrome	2193.49	12.53	1060	167315	32999	110387925
Sedation	1903.74	12.53	1234	167141	68449	110352475
Suicide attempt	1784.28	12.53	1383	166992	102011	110318913
Psychotic disorder	1761.01	12.53	1048	167327	49889	110371035
Dyskinesia	1609.87	12.53	993	167382	50453	110370471
Hallucination, auditory	1551.32	12.53	772	167603	25625	110395299
Parkinsonism	1527.13	12.53	723	167652	21464	110399460
Suicidal ideation	1405.80	12.53	1156	167219	92781	110328143
Delusion	1399.66	12.53	696	167679	23059	110397865
Sexual dysfunction	1360.97	12.53	506	167869	8024	110412900
Blood prolactin abnormal	1187.98	12.53	374	168001	3461	110417463
Product use in unapproved indication	1169.49	12.53	2285	166090	445092	109975832
Treatment noncompliance	1167.43	12.53	934	167441	72056	110348868
Hyperprolactinaemia	1001.39	12.53	377	167998	6198	110414726
Weight increased	894.73	12.53	1972	166403	417672	110003252
Mania	890.02	12.53	492	167883	20304	110400620
Anosognosia	885.64	12.53	304	168071	3770	110417154
Aggression	867.34	12.53	720	167655	58490	110362434
Drug interaction	852.94	12.53	2154	166221	498029	109922895
Agitation	807.65	12.53	927	167448	112124	110308800
Gambling disorder	785.45	12.53	239	168136	1952	110418972
Disturbance in social behaviour	784.76	12.53	294	168081	4764	110416160
Tremor	779.80	12.53	1227	167148	201005	110219919
Oculogyric crisis	767.57	12.53	269	168106	3563	110417361
Psychotic symptom	746.10	12.53	264	168111	3603	110417321
Salivary hypersecretion	734.11	12.53	408	167967	17013	110403911
Intentional self-injury	691.78	12.53	522	167853	36907	110384017
Metabolic disorder	691.07	12.53	332	168043	10178	110410746
Restlessness	687.78	12.53	617	167758	55642	110365282
Abnormal behaviour	635.54	12.53	505	167870	38534	110382390
Irritability	611.58	12.53	538	167837	47271	110373653
Somnolence	600.80	12.53	1369	167006	296080	110124844
Intentional overdose	600.21	12.53	867	167508	131634	110289290
Schizophrenia	579.53	12.53	380	167995	21446	110399478
Personality change	576.82	12.53	298	168077	10704	110410220
Muscle rigidity	548.66	12.53	381	167994	23650	110397274
Blood creatine phosphokinase increased	497.87	12.53	585	167790	72492	110348432
Anxiety	451.44	12.53	1350	167025	343728	110077196
Drug abuse	446.07	12.53	893	167482	176518	110244406
Electrocardiogram QT prolonged	444.57	12.53	679	167696	108281	110312643
Catatonia	439.12	12.53	251	168124	11049	110409875
Joint swelling	420.52	12.53	82	168293	442763	109978161
Hypersexuality	407.07	12.53	141	168234	1799	110419125
Psychomotor hyperactivity	406.45	12.53	297	168078	19980	110400944
Serotonin syndrome	400.36	12.53	472	167903	58681	110362243
Infusion related reaction	394.21	12.53	56	168319	381106	110039818
Thinking abnormal	393.19	12.53	260	168115	14880	110406044
Arthralgia	388.87	12.53	369	168006	779263	109641661
Dyspnoea	374.91	12.53	698	167677	1106174	109314750
Mental impairment	370.87	12.53	294	168081	22345	110398579
Apathy	367.26	12.53	256	168119	15983	110404941
Diarrhoea	358.00	12.53	751	167624	1138754	109282170
Stubbornness	351.53	12.53	90	168285	351	110420573
Psychiatric decompensation	345.64	12.53	171	168204	5594	110415330
Pain	341.36	12.53	582	167793	954373	109466551
Galactorrhoea	340.81	12.53	153	168222	4002	110416922
Paranoia	335.67	12.53	276	168099	22098	110398826
Persecutory delusion	334.39	12.53	172	168203	6119	110414805
Arthropathy	330.54	12.53	29	168346	287493	110133431
Overdose	329.78	12.53	940	167435	232854	110188070
Social avoidant behaviour	312.26	12.53	156	168219	5213	110415711
Psychiatric symptom	311.47	12.53	187	168188	9026	110411898
Febrile neutropenia	306.25	12.53	56	168319	316711	110104213
Systemic lupus erythematosus	305.43	12.53	21	168354	254317	110166607
Blood prolactin increased	303.23	12.53	146	168229	4496	110416428
Completed suicide	299.57	12.53	930	167445	241451	110179473
Swelling	299.37	12.53	82	168293	350959	110069965
Synovitis	298.50	12.53	34	168341	274058	110146866
Pneumonia	291.06	12.53	559	167816	876155	109544769
Schizoaffective disorder	281.43	12.53	123	168252	3013	110417911
Glossodynia	279.74	12.53	14	168361	221990	110198934
Drug ineffective	271.86	12.53	3514	164861	1517026	108903898
Depressed mood	268.01	12.53	393	167982	60416	110360508
Anaemia	267.73	12.53	263	168112	546823	109874101
Metabolic syndrome	264.52	12.53	119	168256	3128	110417796
Hallucination	263.72	12.53	518	167857	100914	110320010
Abdominal discomfort	261.03	12.53	137	168238	393721	110027203
Obsessive-compulsive disorder	260.52	12.53	153	168222	7088	110413836
Emotional poverty	259.15	12.53	86	168289	954	110419970
Stomatitis	258.58	12.53	49	168326	270193	110150731
Blood glucose increased	250.76	12.53	595	167780	131901	110289023
Affective disorder	244.40	12.53	173	168202	11068	110409856
Increased appetite	244.24	12.53	194	168181	14783	110406141
Rash	241.73	12.53	560	167815	820404	109600520
Orthostatic hypertension	235.77	12.53	80	168295	955	110419969
Drooling	233.84	12.53	142	168233	6997	110413927
Rhabdomyolysis	231.44	12.53	544	167831	119857	110301067
Rheumatoid arthritis	230.45	12.53	84	168291	299529	110121395
Contraindicated product administered	229.21	12.53	49	168326	248218	110172706
Mental disorder	229.11	12.53	289	168086	38502	110382422
Tic	228.58	12.53	110	168265	3383	110417541
Folliculitis	226.94	12.53	6	168369	167647	110253277
Sinusitis	226.81	12.53	84	168291	296604	110124320
Underdose	224.59	12.53	371	168004	63183	110357741
Disinhibition	221.30	12.53	104	168271	3030	110417894
Antipsychotic drug level increased	220.74	12.53	136	168239	6879	110414045
Hypersensitivity	218.19	12.53	177	168198	403821	110017103
Compulsive shopping	217.18	12.53	72	168303	796	110420128
Cogwheel rigidity	216.69	12.53	108	168267	3590	110417334
Impulse-control disorder	216.41	12.53	92	168283	2102	110418822
Drug hypersensitivity	215.56	12.53	224	168151	453866	109967058
Pruritus	210.51	12.53	351	168024	581209	109839715
Myocarditis	206.93	12.53	242	168133	29813	110391111
Antipsychotic drug level below therapeutic	205.80	12.53	83	168292	1652	110419272
Sopor	202.82	12.53	264	168111	36282	110384642
General physical health deterioration	201.62	12.53	210	168165	425085	109995839
Mood altered	199.42	12.53	202	168173	21173	110399751
Impaired healing	198.41	12.53	31	168344	196686	110224238
Wheezing	197.20	12.53	71	168304	255159	110165765
Malignant neoplasm progression	196.84	12.53	19	168356	174548	110246376
Hypomania	194.38	12.53	145	168230	10065	110410859
Drug intolerance	193.51	12.53	200	168175	406312	110014612
Muscle injury	190.72	12.53	5	168370	140802	110280122
Osteoarthritis	190.63	12.53	26	168349	182597	110238327
Priapism	190.49	12.53	116	168259	5745	110415179
Nasopharyngitis	187.74	12.53	194	168181	394167	110026757
Euphoric mood	187.64	12.53	134	168241	8693	110412231
Sinus tachycardia	183.80	12.53	279	168096	44214	110376710
Homicidal ideation	183.68	12.53	96	168279	3531	110417393
Gestational diabetes	182.48	12.53	123	168252	7266	110413658
Toxicity to various agents	179.87	12.53	1300	167075	479255	109941669
Seizure	179.83	12.53	740	167635	220445	110200479
Posture abnormal	178.94	12.53	101	168274	4337	110416587
Blister	177.80	12.53	62	168313	227314	110193610
Musculoskeletal pain	177.58	12.53	32	168343	182991	110237933
Irritable bowel syndrome	177.16	12.53	21	168354	164194	110256730
Torticollis	176.80	12.53	90	168285	3131	110417793
Peripheral swelling	173.56	12.53	216	168159	403818	110017106
Infection	172.59	12.53	178	168197	362022	110058902
Diabetes mellitus	171.70	12.53	431	167944	98950	110321974
Hepatic enzyme increased	171.46	12.53	142	168233	320750	110100174
Hostility	170.68	12.53	83	168292	2613	110418311
Urticaria	170.50	12.53	141	168234	318716	110102208
Wound	169.91	12.53	72	168303	234365	110186559
Pain in extremity	167.99	12.53	303	168072	486815	109934109
Lower respiratory tract infection	167.84	12.53	80	168295	243026	110177898
Cough	166.61	12.53	279	168096	461362	109959562
Mobility decreased	165.65	12.53	77	168298	237345	110183579
Hypothermia	163.39	12.53	201	168174	26101	110394823
Hallucination, visual	163.10	12.53	248	168127	39357	110381567
Pericarditis	162.51	12.53	65	168310	219049	110201875
Hallucinations, mixed	162.25	12.53	122	168253	8571	110412353
Coma	160.30	12.53	468	167907	117401	110303523
Bruxism	160.15	12.53	98	168277	4896	110416028
Psychomotor retardation	155.85	12.53	114	168261	7678	110413246
Ill-defined disorder	153.09	12.53	27	168348	156826	110264098
Joint range of motion decreased	152.44	12.53	8	168367	121824	110299100
Depression	150.47	12.53	911	167464	316424	110104500
Drug monitoring procedure incorrectly performed	149.31	12.53	53	168322	730	110420194
Libido increased	148.32	12.53	74	168301	2465	110418459
Bursitis	146.83	12.53	14	168361	129904	110291020
Sleep disorder due to general medical condition, insomnia type	145.97	12.53	3	168372	105640	110315284
Fibromyalgia	145.45	12.53	40	168335	170869	110250055
Alopecia	145.42	12.53	206	168169	364547	110056377
Delusion of grandeur	144.35	12.53	70	168305	2190	110418734
Muscle twitching	142.91	12.53	201	168174	29734	110391190
Psoriatic arthropathy	141.66	12.53	61	168314	196700	110224224
Pyrexia	141.24	12.53	797	167578	897468	109523456
Arthritis	141.17	12.53	40	168335	167546	110253378
Refusal of treatment by patient	140.06	12.53	116	168259	9378	110411546
Gambling	139.43	12.53	42	168333	330	110420594
Insurance issue	138.82	12.53	121	168254	10491	110410433
Product administered to patient of inappropriate age	137.29	12.53	107	168268	7929	110412995
Disturbance in attention	135.68	12.53	295	168080	61700	110359224
Impulsive behaviour	135.17	12.53	76	168299	3239	110417685
Abdominal pain	134.36	12.53	371	168004	512618	109908306
Bradyphrenia	134.19	12.53	124	168251	11604	110409320
Hyperphagia	133.35	12.53	77	168298	3454	110417470
Compulsive sexual behaviour	131.35	12.53	38	168337	255	110420669
Gastrointestinal disorder	130.54	12.53	106	168269	241846	110179078
Poisoning deliberate	130.48	12.53	180	168195	26151	110394773
Tachycardia	129.41	12.53	684	167691	225961	110194963
Therapeutic product effect decreased	129.39	12.53	109	168266	244207	110176717
Disease progression	129.08	12.53	109	168266	243925	110176999
Dysarthria	129.08	12.53	349	168026	83772	110337152
Sedation complication	128.64	12.53	155	168220	19700	110401224
Prescribed underdose	127.95	12.53	297	168078	64877	110356047
Insomnia	123.74	12.53	956	167419	359634	110061290
Lung disorder	121.60	12.53	61	168314	179986	110240938
Cognitive disorder	121.41	12.53	350	168025	87161	110333763
Asthenia	120.69	12.53	589	167786	688410	109732514
Neutrophil count increased	120.68	12.53	201	168174	34451	110386473
Substance abuse	120.33	12.53	120	168255	12343	110408581
Acute kidney injury	120.29	12.53	528	167847	634902	109786022
Abdominal pain upper	119.53	12.53	218	168157	348893	110072031
Fatigue	118.73	12.53	1232	167143	1214726	109206198
Bipolar disorder	118.42	12.53	103	168272	8904	110412020
Inflammation	118.22	12.53	74	168301	193164	110227760
Urinary retention	118.04	12.53	300	168075	69383	110351541
Altered state of consciousness	117.98	12.53	267	168108	57359	110363565
Urinary incontinence	117.70	12.53	241	168134	48346	110372578
Anger	117.65	12.53	145	168230	18862	110402062
Gaze palsy	117.36	12.53	70	168305	3337	110417587
Blood triglycerides increased	116.22	12.53	162	168213	23764	110397160
Sepsis	116.04	12.53	200	168175	327146	110093778
Acute psychosis	115.99	12.53	80	168295	4907	110416017
Antipsychotic drug level decreased	115.82	12.53	52	168323	1360	110419564
Bradykinesia	115.64	12.53	110	168265	10678	110410246
Logorrhoea	114.08	12.53	79	168296	4878	110416046
Suppressed lactation	113.62	12.53	35	168340	299	110420625
Pulmonary fibrosis	112.69	12.53	12	168363	102030	110318894
Myelosuppression	112.59	12.53	8	168367	94332	110326592
Discomfort	112.21	12.53	97	168278	214610	110206314
Gynaecomastia	111.82	12.53	102	168273	9388	110411536
Back pain	111.37	12.53	250	168125	370746	110050178
Paraesthesia	109.35	12.53	157	168218	276364	110144560
Night sweats	109.16	12.53	34	168341	133949	110286975
Infarction	107.45	12.53	78	168297	5191	110415733
Acute myopia	106.57	12.53	30	168345	180	110420744
Amenorrhoea	106.39	12.53	98	168277	9133	110411791
Depressive symptom	106.18	12.53	94	168281	8320	110412604
Eosinophil count decreased	104.70	12.53	81	168294	5937	110414987
Self-injurious ideation	104.12	12.53	71	168304	4275	110416649
Erythema	103.35	12.53	178	168197	291269	110129655
Speech disorder	103.18	12.53	264	168111	61305	110359619
Caesarean section	103.11	12.53	116	168259	13701	110407223
Withdrawal syndrome	102.63	12.53	177	168198	31203	110389721
Trismus	102.36	12.53	83	168292	6513	110414411
Depressed level of consciousness	101.94	12.53	389	167986	111889	110309035
Rabbit syndrome	100.27	12.53	33	168342	356	110420568
Mydriasis	100.21	12.53	145	168230	22012	110398912
Libido decreased	99.18	12.53	78	168297	5857	110415067
Intentional product use issue	98.76	12.53	140	168235	247766	110173158
Oppositional defiant disorder	98.54	12.53	35	168340	483	110420441
Dystonic tremor	97.25	12.53	32	168343	345	110420579
Oedema	96.81	12.53	106	168269	209870	110211054
Dyslipidaemia	95.94	12.53	120	168255	15845	110405079
Pleural effusion	93.20	12.53	80	168295	177629	110243295
Liver injury	92.83	12.53	57	168318	150356	110270568
Ascites	92.71	12.53	15	168360	92793	110328131
Peripheral venous disease	92.61	12.53	10	168365	84107	110336817
Grip strength decreased	92.31	12.53	8	168367	80166	110340758
Vertigo	91.59	12.53	316	168059	86554	110334370
Wrong technique in product usage process	91.45	12.53	317	168058	87031	110333893
Nausea	91.36	12.53	1329	167046	1234361	109186563
Atrial fibrillation	91.16	12.53	130	168245	229512	110191412
Colitis	90.78	12.53	22	168353	102301	110318623
Off label use	90.15	12.53	2950	165425	1497235	108923689
Cytokine release syndrome	89.93	12.53	4	168371	70302	110350622
Gastrointestinal haemorrhage	89.90	12.53	72	168303	165446	110255478
Rectal haemorrhage	89.72	12.53	35	168340	119798	110301126
Wound infection	89.06	12.53	19	168356	96446	110324478
Autism spectrum disorder	88.61	12.53	48	168327	1900	110419024
Headache	88.41	12.53	888	167487	881489	109539435
Symptom recurrence	86.91	12.53	66	168309	4706	110416218
Hypertonia	86.86	12.53	84	168291	8322	110412602
Paradoxical drug reaction	86.54	12.53	90	168285	9727	110411197
Stupor	86.17	12.53	83	168292	8182	110412742
Choreoathetosis	86.15	12.53	45	168330	1653	110419271
Mood swings	85.77	12.53	137	168238	22675	110398249
Blunted affect	85.65	12.53	32	168343	514	110420410
Flat affect	85.07	12.53	51	168324	2454	110418470
Contusion	84.12	12.53	141	168234	233220	110187704
Antipsychotic drug level above therapeutic	83.70	12.53	50	168325	2390	110418534
Decreased appetite	83.67	12.53	406	167969	475440	109945484
Upper respiratory tract infection	83.53	12.53	48	168327	131280	110289644
Tension	83.27	12.53	66	168309	5012	110415912
Affect lability	82.88	12.53	121	168254	18516	110402408
Behaviour disorder	82.47	12.53	87	168288	9560	110411364
Injury	82.25	12.53	89	168286	177176	110243748
Victim of child abuse	81.87	12.53	39	168336	1172	110419752
Economic problem	81.63	12.53	60	168315	4071	110416853
Pleurothotonus	80.05	12.53	49	168326	2449	110418475
Intentional product misuse	79.89	12.53	407	167968	132497	110288427
Mutism	79.71	12.53	53	168322	3060	110417864
Hypokinesia	79.23	12.53	129	168246	21697	110399227
Drug dependence	79.22	12.53	210	168165	49810	110371114
Abortion induced	78.88	12.53	78	168297	7941	110412983
Oromandibular dystonia	78.59	12.53	38	168337	1181	110419743
Abortion spontaneous	78.30	12.53	166	168209	34116	110386808
Poor personal hygiene	78.24	12.53	31	168344	588	110420336
Refusal of examination	76.03	12.53	24	168351	224	110420700
Pregnancy on contraceptive	75.98	12.53	35	168340	973	110419951
Stereotypy	75.69	12.53	35	168340	982	110419942
Cardiac failure congestive	75.55	12.53	71	168304	150929	110269995
Enuresis	75.37	12.53	57	168318	4039	110416885
Hyperhidrosis	75.33	12.53	516	167859	186782	110234142
Substance-induced psychotic disorder	75.32	12.53	64	168311	5360	110415564
Epidural lipomatosis	75.21	12.53	44	168331	2023	110418901
Self-destructive behaviour	74.99	12.53	33	168342	822	110420102
Blood prolactin decreased	74.88	12.53	25	168350	283	110420641
Hyperreflexia	74.86	12.53	82	168293	9403	110411521
Water intoxication	74.49	12.53	34	168341	925	110419999
Bipolar I disorder	73.72	12.53	45	168330	2238	110418686
Septic shock	73.19	12.53	79	168296	157449	110263475
Haematochezia	72.37	12.53	43	168332	115481	110305443
Hypoaesthesia	72.33	12.53	241	168134	313982	110106942
Oedema peripheral	72.33	12.53	257	168118	328403	110092521
Soliloquy	72.27	12.53	34	168341	993	110419931
Inappropriate schedule of product administration	72.06	12.53	544	167831	203093	110217831
Restless legs syndrome	71.66	12.53	132	168243	24494	110396430
Dysphagia	71.46	12.53	439	167936	153161	110267763
Therapeutic product effect variable	71.35	12.53	47	168328	2671	110418253
Social problem	71.13	12.53	41	168334	1833	110419091
Pneumonia aspiration	70.91	12.53	278	168097	80955	110339969
Hypoprolactinaemia	70.54	12.53	15	168360	18	110420906
Plasma cell myeloma	70.53	12.53	7	168368	62929	110357995
Pseudomyopia	70.51	12.53	21	168354	158	110420766
Spasmodic dysphonia	69.90	12.53	28	168347	547	110420377
Liver disorder	69.86	12.53	68	168307	142175	110278749
Suicidal behaviour	69.57	12.53	51	168324	3446	110417478
Renal failure	69.33	12.53	151	168224	226423	110194501
Granulocytopenia	69.22	12.53	91	168284	12624	110408300
Sexually inappropriate behaviour	69.06	12.53	29	168346	642	110420282
Electrocardiogram QRS complex prolonged	69.05	12.53	92	168283	12929	110407995
Nail disorder	68.88	12.53	5	168370	57930	110362994
Sudden death	68.78	12.53	129	168246	24266	110396658
Myoclonus	68.77	12.53	154	168221	32844	110388080
Lymphocyte count abnormal	68.71	12.53	44	168331	2382	110418542
Multiple organ dysfunction syndrome	68.37	12.53	78	168297	151632	110269292
Malignant catatonia	67.63	12.53	29	168346	677	110420247
Substance use	67.41	12.53	44	168331	2462	110418462
Obsessive thoughts	67.35	12.53	35	168340	1272	110419652
Hiccups	66.82	12.53	90	168285	12779	110408145
Inappropriate affect	66.70	12.53	38	168337	1661	110419263
Thrombocytopenia	64.64	12.53	292	168083	348593	110072331
Melaena	64.59	12.53	13	168362	68744	110352180
Paroxysmal perceptual alteration	64.43	12.53	22	168353	268	110420656
Sciatica	64.36	12.53	30	168345	92369	110328555
Skin ulcer	64.21	12.53	10	168365	63635	110357289
Haemoptysis	63.97	12.53	15	168360	71339	110349585
Inappropriate antidiuretic hormone secretion	63.96	12.53	152	168223	33699	110387225
Cytomegalovirus infection	63.87	12.53	5	168370	54439	110366485
Gait inability	63.79	12.53	68	168307	136308	110284616
Interstitial lung disease	63.49	12.53	71	168304	139263	110281661
Pancytopenia	63.06	12.53	141	168234	209472	110211452
Respiratory depression	62.98	12.53	146	168229	31855	110389069
Movement disorder	62.97	12.53	158	168217	36246	110384678
Herpes zoster	62.89	12.53	44	168331	108335	110312589
Psychomotor skills impaired	62.75	12.53	65	168310	6993	110413931
Trimethylaminuria	62.58	12.53	20	168355	195	110420729
Autoimmune disorder	62.32	12.53	12	168363	65471	110355453
Megacolon	62.26	12.53	52	168323	4253	110416671
Social anxiety disorder	61.94	12.53	30	168345	936	110419988
Crying	61.92	12.53	127	168248	25501	110395423
Eye movement disorder	61.48	12.53	75	168300	9653	110411271
Child abuse	61.23	12.53	29	168346	860	110420064
Loss of libido	60.77	12.53	45	168330	3088	110417836
Decreased eye contact	60.43	12.53	29	168346	886	110420038
Asthma	60.35	12.53	188	168187	250103	110170821
Frequent bowel movements	60.18	12.53	17	168358	71373	110349551
Physical assault	60.15	12.53	35	168340	1593	110419331
Accidental exposure to product by child	59.94	12.53	45	168330	3153	110417771
Psychosexual disorder	58.93	12.53	18	168357	149	110420775
Personality change due to a general medical condition	58.85	12.53	21	168354	294	110420630
Abulia	58.74	12.53	32	168343	1281	110419643
Vomiting	58.22	12.53	1006	167369	909669	109511255
Delusional disorder, unspecified type	58.12	12.53	28	168347	863	110420061
Negative symptoms in schizophrenia	58.06	12.53	19	168356	201	110420723
Personality disorder	58.04	12.53	84	168291	12753	110408171
Apraxia	58.03	12.53	46	168329	3494	110417430
Pneumonitis	57.87	12.53	22	168353	76509	110344415
Head titubation	57.75	12.53	32	168343	1325	110419599
Malaise	57.68	12.53	700	167675	671119	109749805
Abdominal distension	57.54	12.53	112	168263	174991	110245933
Binge eating	57.47	12.53	25	168350	605	110420319
Substance dependence	57.25	12.53	26	168349	699	110420225
Erectile dysfunction	57.22	12.53	102	168273	18454	110402470
Coronary artery disease	56.96	12.53	19	168356	71671	110349253
Drug level increased	56.91	12.53	181	168194	47538	110373386
Dyspnoea exertional	56.83	12.53	45	168330	104015	110316909
Death	56.71	12.53	737	167638	698132	109722792
Hospitalisation	56.36	12.53	391	167984	142102	110278822
Maternal exposure during pregnancy	55.93	12.53	614	167761	254269	110166655
Hyperthermia	55.69	12.53	109	168266	21163	110399761
Neurodegenerative disorder	55.21	12.53	26	168349	761	110420163
Activation syndrome	55.01	12.53	21	168354	359	110420565
Reduced facial expression	54.67	12.53	45	168330	3606	110417318
Taste disorder	54.32	12.53	16	168359	65371	110355553
Tongue biting	54.30	12.53	41	168334	2898	110418026
Product substitution issue	54.21	12.53	113	168262	22948	110397976
Hypersomnia	54.10	12.53	127	168248	27934	110392990
Delusional disorder, persecutory type	54.09	12.53	24	168351	610	110420314
Sudden cardiac death	53.91	12.53	54	168321	5583	110415341
Knee arthroplasty	53.76	12.53	16	168359	64932	110355992
Loss of consciousness	53.73	12.53	495	167880	195811	110225113
Hypoxia	53.71	12.53	71	168304	129444	110291480
Delirium	53.69	12.53	371	168004	134654	110286270
Disturbance in sexual arousal	53.66	12.53	21	168354	385	110420539
Feeling guilty	53.58	12.53	27	168348	919	110420005
Ataxia	53.47	12.53	132	168243	29976	110390948
Keratoconus	53.45	12.53	17	168358	163	110420761
Therapy cessation	53.36	12.53	170	168205	44687	110376237
Miosis	53.18	12.53	109	168266	21874	110399050
Prescribed overdose	53.18	12.53	269	168106	87312	110333612
Disorientation	53.13	12.53	231	168144	70440	110350484
Antidepressant drug level above therapeutic	53.08	12.53	25	168350	732	110420192
Compulsions	52.97	12.53	21	168354	399	110420525
Diabetic ketoacidosis	52.43	12.53	162	168213	41896	110379028
Productive cough	52.34	12.53	58	168317	114247	110306677
Bone marrow failure	52.17	12.53	12	168363	57836	110363088
Cerebral haemorrhage	52.00	12.53	17	168358	64951	110355973
Reversible cerebral vasoconstriction syndrome	51.89	12.53	49	168326	4712	110416212
Abortion	51.87	12.53	32	168343	1622	110419302
Rhinalgia	51.79	12.53	45	168330	3884	110417040
Nephrogenic diabetes insipidus	51.70	12.53	37	168338	2408	110418516
Obesity	51.48	12.53	322	168053	113029	110307895
Fluid retention	51.23	12.53	41	168334	94266	110326658
Osteoporosis	51.08	12.53	35	168340	87117	110333807
Tachyphrenia	50.61	12.53	36	168339	2320	110418604
Obsessive-compulsive symptom	50.58	12.53	19	168356	310	110420614
Haematuria	50.45	12.53	32	168343	82973	110337951
Parkinsonian rest tremor	50.44	12.53	20	168355	380	110420544
Parkinsonian gait	50.39	12.53	27	168348	1045	110419879
Anxiolytic therapy	50.32	12.53	13	168362	53	110420871
Drug therapy enhancement	50.32	12.53	13	168362	53	110420871
Post-traumatic stress disorder	50.29	12.53	56	168319	6540	110414384
Gastrooesophageal reflux disease	50.19	12.53	126	168249	179850	110241074
Leukopenia	50.12	12.53	393	167982	148398	110272526
Hepatotoxicity	50.02	12.53	17	168358	63383	110357541
Hip arthroplasty	49.50	12.53	12	168363	55801	110365123
Muscle contracture	49.30	12.53	38	168337	2770	110418154
Victim of crime	49.17	12.53	29	168346	1354	110419570
Hallucination, olfactory	49.12	12.53	22	168353	572	110420352
Analgesic drug level above therapeutic	49.07	12.53	21	168354	488	110420436
Substance use disorder	49.01	12.53	58	168317	7232	110413692
Muscle contractions involuntary	48.94	12.53	46	168329	4398	110416526
Lactation disorder	48.83	12.53	18	168357	278	110420646
Cardiac failure	48.80	12.53	136	168239	187490	110233434
Major depression	48.75	12.53	70	168305	10551	110410373
Schizophreniform disorder	48.75	12.53	16	168359	171	110420753
Lower limb fracture	48.68	12.53	27	168348	75321	110345603
Chest pain	48.68	12.53	354	168021	376021	110044903
Electrocardiogram QT shortened	48.47	12.53	18	168357	284	110420640
Generalised tonic-clonic seizure	48.42	12.53	188	168187	54492	110366432
Treatment failure	48.41	12.53	237	168138	276997	110143927
Dissociation	48.34	12.53	67	168308	9775	110411149
Staring	48.31	12.53	38	168337	2854	110418070
Dysphoria	48.02	12.53	54	168321	6374	110414550
Drug effective for unapproved indication	47.76	12.53	81	168294	14086	110406838
Osteonecrosis of jaw	47.42	12.53	8	168367	48009	110372915
Autonomic nervous system imbalance	47.42	12.53	51	168324	5729	110415195
Hyperkalaemia	47.14	12.53	84	168291	135712	110285212
Accommodation disorder	47.13	12.53	22	168353	631	110420293
Hepatic cirrhosis	47.03	12.53	22	168353	67604	110353320
Drug withdrawal syndrome	46.90	12.53	146	168229	37908	110383016
Exostosis	46.87	12.53	7	168368	45949	110374975
Alice in wonderland syndrome	46.63	12.53	12	168363	48	110420876
Anhedonia	46.54	12.53	84	168291	15344	110405580
Polydipsia	46.54	12.53	58	168317	7630	110413294
Red blood cell sedimentation rate increased	46.48	12.53	31	168344	78271	110342653
Somnambulism	46.48	12.53	53	168322	6352	110414572
Food craving	46.28	12.53	32	168343	1971	110418953
Acute myeloid leukaemia	46.15	12.53	3	168372	38107	110382817
Foot deformity	45.89	12.53	9	168366	48471	110372453
Cardio-respiratory arrest	45.89	12.53	318	168057	115518	110305406
Bankruptcy	45.69	12.53	11	168364	31	110420893
Hypercalcaemia	45.58	12.53	8	168367	46649	110374275
Tongue movement disturbance	44.91	12.53	20	168355	513	110420411
Neuropathy peripheral	44.39	12.53	133	168242	179144	110241780
Akinesia	44.35	12.53	40	168335	3627	110417297
Colitis ulcerative	44.11	12.53	32	168343	77331	110343593
Somatic hallucination	43.97	12.53	12	168363	63	110420861
Hypercholesterolaemia	43.94	12.53	44	168331	90793	110330131
Onychomycosis	43.93	12.53	4	168371	38527	110382397
Delusion of reference	43.89	12.53	16	168359	239	110420685
Male sexual dysfunction	43.83	12.53	17	168358	304	110420620
Product availability issue	43.77	12.53	57	168318	7833	110413091
Basal cell carcinoma	43.71	12.53	8	168367	45262	110375662
Muscular weakness	43.61	12.53	212	168163	248256	110172668
Epistaxis	43.17	12.53	83	168292	130289	110290635
International normalised ratio increased	43.16	12.53	41	168334	86731	110334193
Vision blurred	43.02	12.53	340	168035	128682	110292242
Diverticulitis	42.84	12.53	14	168361	53508	110367416
Eosinophilic myocarditis	42.82	12.53	31	168344	2054	110418870
Homosexuality	42.74	12.53	11	168364	44	110420880
Liver function test increased	42.71	12.53	43	168332	88505	110332419
Prostate cancer	42.67	12.53	4	168371	37637	110383287
Sleep-related eating disorder	42.65	12.53	23	168352	902	110420022
Soft tissue injury	42.60	12.53	32	168343	2244	110418680
Palmar-plantar erythrodysaesthesia syndrome	42.41	12.53	6	168369	41019	110379905
Floppy iris syndrome	42.21	12.53	17	168358	337	110420587
Negative thoughts	42.09	12.53	28	168347	1618	110419306
Adjustment disorder with depressed mood	41.84	12.53	8	168367	43875	110377049
Immunodeficiency	41.79	12.53	5	168370	38833	110382091
Blood pressure systolic increased	41.53	12.53	39	168336	82952	110337972
Emotional distress	41.20	12.53	156	168219	44691	110376233
Bronchiectasis	41.05	12.53	4	168371	36489	110384435
Hyperkinesia	41.03	12.53	36	168339	3148	110417776
Post-traumatic neck syndrome	41.00	12.53	33	168342	2562	110418362
Homeless	40.93	12.53	13	168362	124	110420800
Troponin T increased	40.72	12.53	41	168334	4265	110416659
Type 1 diabetes mellitus	40.61	12.53	59	168316	8988	110411936
Threatened labour	40.60	12.53	20	168355	648	110420276
Chills	40.59	12.53	151	168224	190429	110230495
Poor quality sleep	40.58	12.53	114	168261	27963	110392961
Heat stroke	40.27	12.53	29	168346	1906	110419018
Ideas of reference	40.18	12.53	14	168361	182	110420742
Injection site reaction	39.90	12.53	46	168329	89024	110331900
Disorganised speech	39.89	12.53	36	168339	3267	110417657
Lupus-like syndrome	39.84	12.53	7	168368	40785	110380139
Negativism	39.79	12.53	22	168353	907	110420017
Oropharyngeal spasm	39.70	12.53	18	168357	482	110420442
Weight decreased	39.62	12.53	489	167886	467568	109953356
Slow response to stimuli	39.56	12.53	29	168346	1959	110418965
Product prescribing error	39.52	12.53	169	168206	51162	110369762
Metastases to liver	39.48	12.53	4	168371	35382	110385542
Rash pruritic	39.41	12.53	55	168320	98014	110322910
Oscillopsia	38.95	12.53	17	168358	415	110420509
Haemoglobin decreased	38.75	12.53	221	168154	248506	110172418
Resting tremor	38.57	12.53	27	168348	1696	110419228
Neck pain	38.53	12.53	81	168294	123049	110297875
Hallucination, tactile	37.97	12.53	22	168353	993	110419931
Anterograde amnesia	37.96	12.53	21	168354	867	110420057
Paraphilia	37.87	12.53	11	168364	75	110420849
Incorrect dose administered	37.84	12.53	279	168096	103362	110317562
Bronchitis	37.81	12.53	118	168257	156914	110264010
Grandiosity	37.18	12.53	18	168357	561	110420363
Coeliac disease	36.93	12.53	10	168365	43177	110377747
Emotional disorder	36.61	12.53	78	168297	16082	110404842
Urinary tract infection	36.57	12.53	319	168056	325963	110094961
Divorced	36.25	12.53	9	168366	30	110420894
Rebound psychosis	36.23	12.53	16	168359	402	110420522
Suicide threat	36.13	12.53	11	168364	90	110420834
Pulmonary valve incompetence	35.88	12.53	31	168344	2655	110418269
Psychotic behaviour	35.86	12.53	24	168351	1401	110419523
Exhibitionism	35.81	12.53	10	168365	58	110420866
Acute myocardial infarction	35.69	12.53	45	168330	83732	110337192
Cataract	35.66	12.53	41	168334	79444	110341480
Myelodysplastic syndrome	35.39	12.53	7	168368	37477	110383447
Influenza	35.35	12.53	135	168240	168966	110251958
Suspiciousness	35.17	12.53	19	168356	748	110420176
Coordination abnormal	35.07	12.53	101	168274	25127	110395797
Road traffic accident	35.01	12.53	69	168306	107329	110313595
Distractibility	34.97	12.53	20	168355	881	110420043
Illusion	34.89	12.53	27	168348	1980	110418944
Rash erythematous	34.81	12.53	44	168331	81788	110339136
Taciturnity	34.66	12.53	7	168368	5	110420919
Dyspepsia	34.64	12.53	161	168214	190804	110230120
Morbid thoughts	34.60	12.53	20	168355	899	110420025
COVID-19	34.38	12.53	225	168150	244835	110176089
Vitamin B12 increased	34.32	12.53	27	168348	2028	110418896
Bladder dilatation	34.32	12.53	29	168346	2410	110418514
Bronchopulmonary aspergillosis	34.32	12.53	3	168372	29860	110391064
Juvenile idiopathic arthritis	34.27	12.53	44	168331	5963	110414961
Metastases to bone	33.85	12.53	4	168371	31368	110389556
Psoriasis	33.84	12.53	105	168270	139888	110281036
Injection site erythema	33.83	12.53	57	168318	94119	110326805
Concussion	33.76	12.53	62	168313	11476	110409448
Mycobacterial peritonitis	33.64	12.53	13	168362	230	110420694
Back injury	33.61	12.53	15	168360	47384	110373540
Thrombosis	33.57	12.53	72	168303	108590	110312334
Dry skin	33.53	12.53	71	168304	107582	110313342
Chronic kidney disease	33.53	12.53	40	168335	76251	110344673
Mycobacterium fortuitum infection	33.49	12.53	16	168359	484	110420440
Neuralgia	33.36	12.53	16	168359	48462	110372462
Post cholecystectomy syndrome	33.30	12.53	19	168356	833	110420091
Neglect of personal appearance	33.17	12.53	15	168360	399	110420525
Tumour lysis syndrome	33.05	12.53	4	168371	30797	110390127
Intellectual disability	33.05	12.53	26	168349	1953	110418971
Conversion disorder	32.98	12.53	28	168347	2342	110418582
Neutropenic sepsis	32.98	12.53	4	168371	30742	110390182
Birdshot chorioretinopathy	32.93	12.53	10	168365	81	110420843
COVID-19 pneumonia	32.91	12.53	8	168367	37135	110383789
Mucosal inflammation	32.89	12.53	60	168315	96081	110324843
Thermal burn	32.85	12.53	50	168325	7938	110412986
Blood cholesterol increased	32.81	12.53	157	168218	184628	110236296
Anaphylactic reaction	32.66	12.53	79	168296	114221	110306703
Paraesthesia oral	32.40	12.53	6	168369	33665	110387259
Fear	32.38	12.53	93	168282	23100	110397824
Bacteraemia	32.36	12.53	12	168363	42378	110378546
Accidental death	32.28	12.53	39	168336	4970	110415954
Gout	32.16	12.53	8	168367	36558	110384366
Sternal fracture	32.14	12.53	32	168343	3284	110417640
Nervousness	32.06	12.53	126	168249	36725	110384199
Diabetic coma	31.95	12.53	22	168353	1346	110419578
Premature labour	31.66	12.53	53	168322	9119	110411805
Patient restraint	31.61	12.53	10	168365	94	110420830
Dementia	31.46	12.53	113	168262	31560	110389364
Gaming disorder	31.45	12.53	7	168368	12	110420912
Bone marrow oedema syndrome	31.29	12.53	9	168366	59	110420865
Manic symptom	31.16	12.53	13	168362	283	110420641
Gastric ulcer	30.87	12.53	11	168364	39816	110381108
Respiratory disorder	30.76	12.53	38	168337	71344	110349580
Thrombotic microangiopathy	30.76	12.53	4	168371	29145	110391779
Disease recurrence	30.34	12.53	177	168198	60607	110360317
Full blood count decreased	30.29	12.53	6	168369	32093	110388831
Electroencephalogram abnormal	30.28	12.53	42	168333	6131	110414793
Syringe issue	30.20	12.53	53	168322	9472	110411452
Hypervolaemia	30.15	12.53	19	168356	49441	110371483
Chest discomfort	30.11	12.53	149	168226	173699	110247225
Rhinorrhoea	30.10	12.53	70	168305	102596	110318328
Hepatitis	30.10	12.53	57	168318	89997	110330927
Dry mouth	29.89	12.53	180	168195	199768	110221156
Bone pain	29.87	12.53	33	168342	65100	110355824
Screaming	29.83	12.53	37	168338	4844	110416080
Postural tremor	29.76	12.53	19	168356	1023	110419901
Dependence	29.58	12.53	28	168347	2701	110418223
Alcohol abuse	29.54	12.53	37	168338	4892	110416032
Adjusted calcium increased	29.52	12.53	9	168366	74	110420850
Injection site pruritus	29.48	12.53	21	168354	51237	110369687
Dementia with Lewy bodies	29.37	12.53	19	168356	1047	110419877
Slow speech	29.30	12.53	31	168344	3417	110417507
Nuchal rigidity	29.21	12.53	20	168355	1212	110419712
Ear pain	29.08	12.53	23	168352	53203	110367721
Oral candidiasis	28.97	12.53	16	168359	44744	110376180
Auditory disorder	28.85	12.53	21	168354	1403	110419521
Pneumothorax	28.65	12.53	9	168366	35276	110385648
Lung neoplasm malignant	28.63	12.53	8	168367	33834	110387090
Bundle branch block right	28.63	12.53	60	168315	12231	110408693
Rebound effect	28.53	12.53	67	168308	14739	110406185
Full blood count abnormal	28.45	12.53	26	168349	56026	110364898
Subdural haematoma	28.37	12.53	10	168365	36444	110384480
Lethargy	28.18	12.53	241	168134	93335	110327589
Pyramidal tract syndrome	28.13	12.53	17	168358	830	110420094
Congestive cardiomyopathy	28.12	12.53	65	168310	14154	110406770
High density lipoprotein decreased	28.11	12.53	39	168336	5694	110415230
Protrusion tongue	27.85	12.53	14	168361	474	110420450
Drug monitoring procedure not performed	27.83	12.53	20	168355	1310	110419614
Muscle spasms	27.71	12.53	280	168095	277877	110143047
Fungal infection	27.70	12.53	22	168353	50784	110370140
Drug-induced liver injury	27.66	12.53	92	168283	119975	110300949
Migraine	27.55	12.53	151	168224	171501	110249423
Rash maculo-papular	27.52	12.53	44	168331	74178	110346746
Drug screen false positive	27.31	12.53	20	168355	1349	110419575
Blood pressure systolic abnormal	27.24	12.53	3	168372	24847	110396077
Delusional perception	27.13	12.53	13	168362	396	110420528
Nodule	27.08	12.53	8	168367	32623	110388301
Hypocalcaemia	26.93	12.53	36	168339	65330	110355594
Initial insomnia	26.91	12.53	53	168322	10336	110410588
Hip fracture	26.75	12.53	10	168365	35141	110385783
Oligospermia	26.63	12.53	7	168368	31	110420893
Polyuria	26.60	12.53	73	168302	17665	110403259
Monocyte count increased	26.54	12.53	61	168314	13232	110407692
Verbal abuse	26.44	12.53	12	168363	322	110420602
Obstructive airways disorder	26.42	12.53	19	168356	46130	110374794
Excessive sexual fantasies	26.36	12.53	6	168369	12	110420912
Nephropathy toxic	26.22	12.53	5	168370	27473	110393451
Hypomagnesaemia	26.16	12.53	32	168343	60338	110360586
Troponin increased	26.08	12.53	102	168273	29664	110391260
Hypophosphataemia	26.00	12.53	9	168366	33173	110387751
Drug ineffective for unapproved indication	25.98	12.53	255	168120	102583	110318341
Hypokalaemia	25.84	12.53	167	168208	182281	110238643
Leukocytosis	25.75	12.53	155	168220	53673	110367251
Confusional arousal	25.72	12.53	10	168365	180	110420744
Cystitis	25.58	12.53	38	168337	65998	110354926
Theft	25.53	12.53	11	168364	260	110420664
Ejaculation disorder	25.48	12.53	14	168361	570	110420354
Breast feeding	25.30	12.53	15	168360	707	110420217
Antisocial behaviour	25.22	12.53	16	168359	852	110420072
Grimacing	25.19	12.53	16	168359	854	110420070
Clostridium difficile colitis	25.10	12.53	18	168357	43760	110377164
Glomerular filtration rate increased	25.08	12.53	22	168353	1923	110419001
Osteonecrosis	25.01	12.53	10	168365	33731	110387193
Antidepressant drug level increased	24.78	12.53	14	168361	602	110420322
Granulocyte count increased	24.71	12.53	22	168353	1961	110418963
Therapy change	24.69	12.53	50	168325	9947	110410977
Diabetic hyperosmolar coma	24.66	12.53	16	168359	886	110420038
Coloboma	24.64	12.53	6	168369	18	110420906
Tongue spasm	24.59	12.53	9	168366	136	110420788
Polyneuropathy	24.54	12.53	9	168366	32003	110388921
Personal relationship issue	24.48	12.53	10	168365	206	110420718
Ear infection	24.40	12.53	36	168339	62696	110358228
Metastases to central nervous system	24.40	12.53	3	168372	22814	110398110
Dehydration	24.39	12.53	290	168085	279221	110141703
Lactic acidosis	24.33	12.53	67	168308	92744	110328180
Non-high-density lipoprotein cholesterol increased	24.15	12.53	12	168363	396	110420528
Cerebrovascular accident	24.14	12.53	169	168206	181115	110239809
Hypertension	24.03	12.53	592	167783	509492	109911432
Poriomania	23.95	12.53	10	168365	218	110420706
Hemiparesis	23.95	12.53	19	168356	43884	110377040
Hereditary ataxia	23.94	12.53	6	168369	21	110420903
Uterine dilation and curettage	23.92	12.53	14	168361	644	110420280
Hunger	23.92	12.53	39	168336	6565	110414359
Sluggishness	23.85	12.53	42	168333	7525	110413399
Dysphemia	23.71	12.53	30	168345	4007	110416917
Electroconvulsive therapy	23.61	12.53	8	168367	95	110420829
Neutrophilia	23.57	12.53	50	168325	10279	110410645
Chronic obstructive pulmonary disease	23.56	12.53	86	168289	109072	110311852
Muscle tightness	23.39	12.53	62	168313	14700	110406224
Respiratory tract infection	23.35	12.53	46	168329	71571	110349353
Adverse reaction	23.23	12.53	8	168367	29586	110391338
Pulmonary embolism	23.20	12.53	457	167918	214017	110206907
Pregnancy with implant contraceptive	23.20	12.53	23	168352	2349	110418575
Libido disorder	23.08	12.53	11	168364	331	110420593
Walking aid user	23.02	12.53	5	168370	25070	110395854
High-grade B-cell lymphoma	22.88	12.53	10	168365	245	110420679
Self-medication	22.84	12.53	37	168338	6195	110414729
Communication disorder	22.82	12.53	33	168342	5006	110415918
Alcohol use disorder	22.81	12.53	7	168368	59	110420865
Respiratory failure	22.60	12.53	214	168161	215118	110205806
Renal impairment	22.56	12.53	181	168194	188264	110232660
Intermenstrual bleeding	22.52	12.53	39	168336	6895	110414029
Joint dislocation	22.45	12.53	12	168363	34178	110386746
Delusion of parasitosis	22.43	12.53	10	168365	257	110420667
Candida infection	22.37	12.53	24	168351	47985	110372939
Intention tremor	22.36	12.53	15	168360	879	110420045
Musculoskeletal chest pain	22.30	12.53	8	168367	28839	110392085
Compulsive hoarding	22.21	12.53	7	168368	65	110420859
Sleep disorder due to a general medical condition	22.19	12.53	28	168347	52084	110368840
Hypometabolism	22.18	12.53	9	168366	182	110420742
Erection increased	22.17	12.53	11	168364	362	110420562
Joint stiffness	22.09	12.53	43	168332	67200	110353724
Imprisonment	22.08	12.53	14	168361	745	110420179
Blood pressure diastolic abnormal	22.03	12.53	6	168369	25809	110395115
Complicated fracture	21.96	12.53	4	168371	0	110420924
Therapy partial responder	21.91	12.53	113	168262	36948	110383976
Excessive masturbation	21.85	12.53	8	168367	121	110420803
Pulmonary mass	21.83	12.53	15	168360	37286	110383638
Eating disorder	21.78	12.53	99	168276	30759	110390165
Skin exfoliation	21.71	12.53	65	168310	87586	110333338
Anaphylactic shock	21.63	12.53	28	168347	51518	110369406
Decreased activity	21.52	12.53	50	168325	10924	110410000
Target skin lesion	21.51	12.53	10	168365	284	110420640
Bacterial infection	21.47	12.53	23	168352	46013	110374911
Mouth ulceration	21.41	12.53	25	168350	48113	110372811
Basilar artery occlusion	21.32	12.53	10	168365	290	110420634
Myocarditis septic	21.31	12.53	6	168369	36	110420888
Aspartate aminotransferase	21.26	12.53	15	168360	954	110419970
Procedural pain	21.22	12.53	14	168361	35551	110385373
Laryngitis	21.14	12.53	20	168355	42391	110378533
Chronic sinusitis	21.09	12.53	6	168369	25078	110395846
Hyperammonaemia	21.08	12.53	57	168318	13675	110407249
Pseudomonas infection	21.07	12.53	8	168367	27845	110393079
Osteomyelitis	21.04	12.53	15	168360	36585	110384339
Myocardial infarction	20.98	12.53	189	168186	191894	110229030
Bladder cancer	20.90	12.53	3	168372	20289	110400635
Hypoalbuminaemia	20.81	12.53	9	168366	28965	110391959
Bronchospasm	20.77	12.53	10	168365	30229	110390695
Blood immunoglobulin A increased	20.75	12.53	18	168357	1550	110419374
Rales	20.65	12.53	6	168369	24733	110396191
CADASIL	20.65	12.53	6	168369	41	110420883
Neoplasm progression	20.62	12.53	42	168333	64553	110356371
Body dysmorphic disorder	20.57	12.53	11	168364	424	110420500
Pulmonary arterial hypertension	20.56	12.53	12	168363	32556	110388368
Nephrectasia	20.54	12.53	5	168370	15	110420909
Nephrolithiasis	20.34	12.53	44	168331	66168	110354756
Shock haemorrhagic	20.32	12.53	8	168367	27239	110393685
Angina pectoris	20.32	12.53	40	168335	62255	110358669
Electric shock	20.28	12.53	19	168356	1809	110419115
Iatrogenic injury	20.22	12.53	18	168357	1605	110419319
Respiratory arrest	20.18	12.53	155	168220	58144	110362780
White blood cell count increased	20.18	12.53	231	168144	96611	110324313
Selective mutism	20.16	12.53	7	168368	90	110420834
Platelet count decreased	20.14	12.53	239	168136	230204	110190720
Blood creatine phosphokinase	20.05	12.53	10	168365	333	110420591
Hypotonia	19.95	12.53	61	168314	15684	110405240
Hypertriglyceridaemia	19.92	12.53	62	168313	16092	110404832
Asphyxia	19.84	12.53	57	168318	14158	110406766
Abortion threatened	19.84	12.53	11	168364	456	110420468
Duodenal ulcer	19.83	12.53	3	168372	19511	110401413
Cholestasis of pregnancy	19.80	12.53	16	168359	1249	110419675
Transfusion	19.80	12.53	7	168368	25465	110395459
Haematotoxicity	19.77	12.53	4	168371	21078	110399846
Drug effect less than expected	19.76	12.53	38	168337	7282	110413642
Ulcer haemorrhage	19.73	12.53	5	168370	22566	110398358
Shoplifting	19.72	12.53	4	168371	3	110420921
Persistent depressive disorder	19.64	12.53	17	168358	1460	110419464
Fear of weight gain	19.63	12.53	5	168370	19	110420905
Affective ambivalence	19.63	12.53	5	168370	19	110420905
Blood pressure fluctuation	19.62	12.53	54	168321	74770	110346154
Deja vu	19.62	12.53	7	168368	98	110420826
Activated partial thromboplastin time prolonged	19.47	12.53	5	168370	22363	110398561
Faeces discoloured	19.41	12.53	14	168361	33934	110386990
Suspected suicide	19.37	12.53	59	168316	15140	110405784
Renal hypertension	19.28	12.53	9	168366	258	110420666
Facial nerve disorder	19.27	12.53	13	168362	769	110420155
Upper gastrointestinal haemorrhage	19.24	12.53	29	168346	50067	110370857
Oral herpes	19.20	12.53	16	168359	36064	110384860
Locked-in syndrome	19.20	12.53	14	168361	938	110419986
Sexual abuse	19.12	12.53	9	168366	263	110420661
Twin pregnancy	19.12	12.53	14	168361	944	110419980
Foetal exposure during pregnancy	19.09	12.53	38	168337	7467	110413457
Nicotine dependence	19.09	12.53	16	168359	1315	110419609
Polyarthritis	19.08	12.53	3	168372	18960	110401964
Joint hyperextension	19.05	12.53	10	168365	371	110420553
Patient dissatisfaction with treatment	19.05	12.53	10	168365	371	110420553
Neuroleptic-induced deficit syndrome	19.05	12.53	5	168370	22	110420902
Helplessness	19.03	12.53	10	168365	372	110420552
Immunodeficiency common variable	18.87	12.53	12	168363	642	110420282
Hyperaldosteronism	18.85	12.53	12	168363	643	110420281
Femur fracture	18.82	12.53	24	168351	44445	110376479
Arrhythmia	18.80	12.53	175	168200	69400	110351524
Haemorrhoids	18.76	12.53	16	168359	35656	110385268
Respiratory tract congestion	18.61	12.53	12	168363	30845	110390079
Benign ethnic neutropenia	18.59	12.53	7	168368	115	110420809
Narcolepsy	18.58	12.53	17	168358	1571	110419353
Body mass index decreased	18.48	12.53	13	168362	823	110420101
Tubulointerstitial nephritis	18.46	12.53	34	168341	54250	110366674
Trichotillomania	18.41	12.53	8	168367	193	110420731
Breath sounds abnormal	18.07	12.53	8	168367	25396	110395528
Long QT syndrome	18.06	12.53	36	168339	7082	110413842
Nightmare	18.01	12.53	111	168264	38752	110382172
Drug resistance	17.94	12.53	147	168228	56227	110364697
Somatic symptom disorder	17.80	12.53	23	168352	3136	110417788
Immune thrombocytopenia	17.80	12.53	6	168369	22488	110398436
Panic attack	17.64	12.53	89	168286	28851	110392073
Ornithine transcarbamoylase deficiency	17.62	12.53	5	168370	31	110420893
Diabetes insipidus	17.60	12.53	34	168341	6536	110414388
Oesophagitis	17.54	12.53	11	168364	28704	110392220
Injection site bruising	17.52	12.53	32	168343	51231	110369693
Urate nephropathy	17.52	12.53	8	168367	218	110420706
Blood creatinine increased	17.43	12.53	186	168189	182703	110238221
Chemical burn	17.40	12.53	12	168363	736	110420188
Multiple drug therapy	17.37	12.53	38	168337	7976	110412948
Product quality issue	17.28	12.53	60	168315	77239	110343685
Dermatillomania	17.24	12.53	9	168366	330	110420594
Wrong patient received product	17.23	12.53	34	168341	6640	110414284
Tourette's disorder	17.08	12.53	6	168369	80	110420844
Incontinence	17.08	12.53	60	168315	16575	110404349
Device related infection	17.07	12.53	21	168354	39498	110381426
Violence-related symptom	16.88	12.53	13	168362	946	110419978
Glabellar reflex abnormal	16.86	12.53	5	168370	37	110420887
Merycism	16.85	12.53	9	168366	346	110420578
Sinus disorder	16.83	12.53	15	168360	32713	110388211
Squamous cell carcinoma of skin	16.69	12.53	3	168372	17200	110403724
Muscle spasticity	16.69	12.53	18	168357	35897	110385027
White blood cells urine positive	16.68	12.53	36	168339	7488	110413436
Product reconstitution quality issue	16.62	12.53	9	168366	356	110420568
Pulmonary alveolar haemorrhage	16.61	12.53	5	168370	20145	110400779
Impaired self-care	16.58	12.53	20	168355	2544	110418380
Skin necrosis	16.57	12.53	6	168369	21506	110399418
Haemorrhage intracranial	16.49	12.53	12	168363	28957	110391967
Laboratory test abnormal	16.46	12.53	26	168349	44053	110376871
Flight of ideas	16.46	12.53	12	168363	804	110420120
Localised infection	16.45	12.53	25	168350	43023	110377901
Gastroenteritis viral	16.43	12.53	14	168361	31212	110389712
Asocial behaviour	16.37	12.53	6	168369	91	110420833
Squamous cell carcinoma	16.31	12.53	4	168371	18459	110402465
Myositis	16.31	12.53	14	168361	31102	110389822
Hepatic failure	16.29	12.53	52	168323	68687	110352237
Morning sickness	16.25	12.53	12	168363	820	110420104
Excessive eye blinking	16.23	12.53	17	168358	1853	110419071
Foetal anticonvulsant syndrome	16.22	12.53	8	168367	260	110420664
Skin lesion	16.12	12.53	34	168341	51597	110369327
Emphysema	16.11	12.53	5	168370	19751	110401173
Pemphigoid	16.05	12.53	5	168370	19702	110401222
Inability to afford medication	16.04	12.53	25	168350	4051	110416873
Sneezing	16.04	12.53	15	168360	31969	110388955
Balance disorder	16.02	12.53	258	168117	116302	110304622
Female sexual dysfunction	16	12.53	5	168370	45	110420879
Staphylococcal bacteraemia	16	12.53	3	168372	16685	110404239
Glycogen storage disorder	15.96	12.53	4	168371	14	110420910
Mean cell haemoglobin concentration decreased	15.96	12.53	30	168345	5652	110415272
Therapeutic product effect incomplete	15.93	12.53	450	167925	223355	110197569
Abdominal pain lower	15.91	12.53	20	168355	37263	110383661
Chorea	15.85	12.53	22	168353	3213	110417711
Diet refusal	15.84	12.53	12	168363	852	110420072
Hyperbilirubinaemia	15.84	12.53	14	168361	30657	110390267
Sinus arrhythmia	15.82	12.53	18	168357	2152	110418772
Polyhydramnios	15.76	12.53	17	168358	1916	110419008
Prader-Willi syndrome	15.75	12.53	4	168371	15	110420909
Oropharyngeal pain	15.70	12.53	131	168244	135145	110285779
Posterior reversible encephalopathy syndrome	15.70	12.53	17	168358	33844	110387080
Hyporeflexia	15.66	12.53	25	168350	4135	110416789
Potentiating drug interaction	15.59	12.53	46	168329	11597	110409327
Haemophagocytic lymphohistiocytosis	15.59	12.53	15	168360	31544	110389380
Petechiae	15.58	12.53	8	168367	23309	110397615
Radiculopathy	15.58	12.53	5	168370	19331	110401593
Attention deficit hyperactivity disorder	15.57	12.53	26	168349	4465	110416459
Heart rate	15.54	12.53	8	168367	285	110420639
Somatic symptom disorder of pregnancy	15.53	12.53	6	168369	106	110420818
Menstruation irregular	15.53	12.53	30	168345	5767	110415157
Electrocardiogram abnormal	15.50	12.53	63	168312	18646	110402278
Product administration interrupted	15.49	12.53	45	168330	11247	110409677
Neuropsychiatric symptoms	15.48	12.53	14	168361	1274	110419650
Blood ketone body	15.45	12.53	7	168368	187	110420737
Waxy flexibility	15.36	12.53	8	168367	292	110420632
Sputum discoloured	15.36	12.53	12	168363	27933	110392991
Head banging	15.34	12.53	10	168365	558	110420366
Poisoning	15.34	12.53	86	168289	29019	110391905
Breath odour	15.34	12.53	17	168358	1975	110418949
Anuria	15.32	12.53	9	168366	24332	110396592
Amphetamines positive	15.29	12.53	8	168367	295	110420629
Foetal malformation	15.27	12.53	5	168370	53	110420871
Glucose tolerance impaired	15.27	12.53	41	168334	9796	110411128
Pleuritic pain	15.27	12.53	3	168372	16137	110404787
Photopsia	15.25	12.53	31	168344	6183	110414741
Post procedural complication	15.23	12.53	11	168364	26647	110394277
Ejaculation delayed	15.15	12.53	7	168368	196	110420728
Dyskinesia oesophageal	15.10	12.53	5	168370	55	110420869
Feeling abnormal	15.07	12.53	371	168004	180340	110240584
Angioedema	15.07	12.53	88	168287	98412	110322512
Echopraxia	15.02	12.53	5	168370	56	110420868
Alcoholism	14.96	12.53	23	168352	3684	110417240
Drug tolerance decreased	14.92	12.53	12	168363	27528	110393396
Breast discharge	14.84	12.53	12	168363	938	110419986
Epstein-Barr virus infection	14.82	12.53	5	168370	18733	110402191
Therapeutic product ineffective	14.74	12.53	19	168356	2585	110418339
Dysentery	14.73	12.53	14	168361	1357	110419567
Panic disorder	14.71	12.53	22	168353	3439	110417485
Urosepsis	14.67	12.53	15	168360	30660	110390264
Food allergy	14.64	12.53	6	168369	19942	110400982
Gender dysphoria	14.56	12.53	5	168370	62	110420862
Feeling of despair	14.54	12.53	23	168352	3775	110417149
Vasculitis	14.53	12.53	20	168355	35853	110385071
Angle closure glaucoma	14.53	12.53	22	168353	3477	110417447
Lower gastrointestinal haemorrhage	14.51	12.53	5	168370	18481	110402443
Disruptive mood dysregulation disorder	14.50	12.53	4	168371	22	110420902
Skin disorder	14.48	12.53	27	168348	42886	110378038
Diverticulum	14.45	12.53	3	168372	15523	110405401
Pulmonary hypertension	14.37	12.53	40	168335	55180	110365744
Anorgasmia	14.35	12.53	15	168360	1631	110419293
Atelectasis	14.34	12.53	21	168354	36691	110384233
Hot flush	14.26	12.53	52	168323	65984	110354940
Limb injury	14.25	12.53	22	168353	37614	110383310
Blood thyroid stimulating hormone decreased	14.21	12.53	33	168342	7206	110413718
Meningitis streptococcal	14.20	12.53	7	168368	227	110420697
Delusional disorder, erotomanic type	14.14	12.53	5	168370	68	110420856
Pulseless electrical activity	14.10	12.53	4	168371	16753	110404171
Premature baby	14.09	12.53	26	168349	4829	110416095
Condition aggravated	14.04	12.53	1300	167075	733536	109687388
Spleen congestion	14.01	12.53	9	168366	490	110420434
Myoglobin blood increased	14.00	12.53	24	168351	4208	110416716
Urine amphetamine positive	14.00	12.53	6	168369	140	110420784
Cholangitis infective	13.96	12.53	11	168364	828	110420096
Kleptomania	13.94	12.53	4	168371	26	110420898
Gastritis	13.90	12.53	39	168336	53660	110367264
Metastases to lung	13.86	12.53	9	168366	23054	110397870
Normal newborn	13.81	12.53	68	168307	21828	110399096
Metastases to lymph nodes	13.79	12.53	3	168372	15029	110405895
Vaginal discharge	13.79	12.53	5	168370	17903	110403021
Rheumatoid factor increased	13.75	12.53	18	168357	2487	110418437
Energy increased	13.72	12.53	22	168353	3652	110417272
Pulmonary haemorrhage	13.72	12.53	4	168371	16452	110404472
Sleep apnoea syndrome	13.70	12.53	107	168268	40340	110380584
Macular degeneration	13.65	12.53	8	168367	21651	110399273
Oxygen saturation decreased	13.64	12.53	163	168212	156819	110264105
Skin cancer	13.63	12.53	5	168370	17779	110403145
Panic reaction	13.60	12.53	27	168348	5295	110415629
Self esteem inflated	13.53	12.53	3	168372	5	110420919
Stiff tongue	13.53	12.53	3	168372	5	110420919
Blood glucose decreased	13.52	12.53	84	168291	29404	110391520
Scrotal haematoma	13.52	12.53	5	168370	78	110420846
Autoimmune hepatitis	13.49	12.53	3	168372	14801	110406123
Embolism venous	13.47	12.53	26	168349	4997	110415927
Haemorrhage	13.46	12.53	101	168274	106591	110314333
Ejaculation failure	13.44	12.53	8	168367	380	110420544
Pituitary tumour benign	13.41	12.53	19	168356	2828	110418096
Musculoskeletal disorder	13.41	12.53	9	168366	22655	110398269
Chorioretinopathy	13.39	12.53	17	168358	2278	110418646
Escherichia infection	13.38	12.53	10	168365	23806	110397118
Myopathy	13.37	12.53	11	168364	24949	110395975
Therapeutic product effective for unapproved indication	13.36	12.53	6	168369	157	110420767
Tendonitis	13.35	12.53	12	168363	26071	110394853
Gait disturbance	13.32	12.53	534	167841	277674	110143250
Sleep deficit	13.29	12.53	15	168360	1777	110419147
Thought blocking	13.28	12.53	7	168368	262	110420662
Device difficult to use	13.26	12.53	6	168369	18799	110402125
Lipase increased	13.25	12.53	60	168315	18612	110402312
Dropped head syndrome	13.24	12.53	9	168366	539	110420385
Paralogism	13.22	12.53	4	168371	32	110420892
Clonus	13.20	12.53	36	168339	8680	110412244
Judgement impaired	13.20	12.53	13	168362	1317	110419607
Intrusive thoughts	13.19	12.53	10	168365	711	110420213
Hypernatraemia	13.18	12.53	58	168317	17775	110403149
Middle insomnia	13.17	12.53	64	168311	20438	110400486
CYP2D6 polymorphism	13.12	12.53	5	168370	85	110420839
Sexually transmitted disease	13.12	12.53	6	168369	164	110420760
Bone disorder	13.11	12.53	8	168367	21184	110399740
Pregnancy	13.07	12.53	127	168248	50940	110369984
Cytopenia	13.01	12.53	16	168359	30100	110390824
Hyponatriuria	13.00	12.53	4	168371	34	110420890
Induced labour	13.00	12.53	11	168364	916	110420008
Victim of abuse	12.96	12.53	5	168370	88	110420836
Upper-airway cough syndrome	12.95	12.53	4	168371	15853	110405071
Hypoacusis	12.91	12.53	21	168354	35170	110385754
Maternal exposure timing unspecified	12.91	12.53	8	168367	21005	110399919
Pseudodementia	12.90	12.53	4	168371	35	110420889
Dermatitis	12.88	12.53	14	168361	27823	110393101
Confusional state	12.87	12.53	853	167522	467827	109953097
Swelling face	12.82	12.53	85	168290	92236	110328688
Pica	12.81	12.53	5	168370	91	110420833
Back disorder	12.80	12.53	8	168367	20914	110400010
Transient ischaemic attack	12.78	12.53	52	168323	63930	110356994
Dysbiosis	12.77	12.53	16	168359	2116	110418808
Organising pneumonia	12.75	12.53	3	168372	14240	110406684
Abnormal weight gain	12.73	12.53	21	168354	3570	110417354
Maternal exposure during breast feeding	12.69	12.53	23	168352	4215	110416709
Cataplexy	12.68	12.53	12	168363	1157	110419767
Premature delivery	12.66	12.53	85	168290	30547	110390377
Hyperosmolar state	12.61	12.53	10	168365	760	110420164

FDA Adverse Event Reporting System (Pediatric)

MedDRA adverse event term	Likelihood ratio	Likelihood ratio threshold	Patients taking drug having adverse event	Patients taking drug not having adverse event	Patients not taking drug having adverse event	Patients not taking drug not having adverse event
Dehydration	28.56	24.14	31	1206	472	112244
Enterococcal sepsis	28.56	24.14	10	1227	10	112706
Right ventricular false tendon	28.56	24.14	10	1227	10	112706

Pharmacologic Action:

Source	Code	Description
ATC	N05AX12	NERVOUS SYSTEM PSYCHOLEPTICS ANTIPSYCHOTICS Other antipsychotics
FDA EPC	N0000175430	Atypical Antipsychotic
MeSH PA	D000928	Antidepressive Agents
MeSH PA	D002492	Central Nervous System Depressants
MeSH PA	D011619	Psychotropic Drugs
MeSH PA	D012702	Serotonin Antagonists
MeSH PA	D014150	Antipsychotic Agents
MeSH PA	D015259	Dopamine Agents
MeSH PA	D017366	Serotonin Receptor Agonists
MeSH PA	D018377	Neurotransmitter Agents
MeSH PA	D018490	Serotonin Agents
MeSH PA	D018491	Dopamine Agonists
MeSH PA	D018492	Dopamine Antagonists
MeSH PA	D058825	Serotonin 5-HT1 Receptor Agonists
MeSH PA	D058830	Serotonin 5-HT2 Receptor Antagonists
MeSH PA	D065127	Dopamine D2 Receptor Antagonists
CHEBI has role	CHEBI:35469	antidepressant
CHEBI has role	CHEBI:35474	anxiolytic drug
CHEBI has role	CHEBI:35941	serotonergic agonist
CHEBI has role	CHEBI:37955	H<small><sub>1</sub></small>-receptor antagonist
CHEBI has role	CHEBI:49103	drug metabolite
CHEBI has role	CHEBI:50779	appetite enhancer
CHEBI has role	CHEBI:65191	second generation antipsychotic

Related Drugs by ATC class:

N05AX Other antipsychotics 11 drugs

brexpiprazole cariprazine iloperidone mosapramine paliperidone pimavanserin prothipendyl risperidone trospium xanomeline zotepine

Drug Use | Suggest Off label Use Form| |View source of the data|

Disease	Relation	SNOMED_ID	DOID
Mixed bipolar I disorder	indication	16506000	DOID:3312
Schizophrenia	indication	58214004	DOID:5419
Bipolar disorder in remission	indication	85248005
Bipolar affective disorder, current episode manic	indication	191618007
Infantile autism	indication	408857007
Agitation associated with Bipolar Mania	indication
Depression Treatment Adjunct	indication
Agitation associated with Schizophrenia	indication
Suicidal thoughts	contraindication	6471006
Neuroleptic malignant syndrome	contraindication	15244003	DOID:14464
Senile dementia	contraindication	15662003
Agranulocytosis	contraindication	17182001	DOID:12987
Myocardial infarction	contraindication	22298006	DOID:5844
Alzheimer's disease	contraindication	26929004	DOID:10652
Orthostatic hypotension	contraindication	28651003
Conduction disorder of the heart	contraindication	44808001
Low blood pressure	contraindication	45007003
Chronic heart failure	contraindication	48447003
Hyperlipidemia	contraindication	55822004	DOID:1168
Cerebrovascular disease	contraindication	62914000	DOID:6713
Diabetes mellitus	contraindication	73211009	DOID:9351
Hyperglycemia	contraindication	80394007	DOID:4195
Leukopenia	contraindication	84828003	DOID:615
Tardive dyskinesia	contraindication	102449007
Seizure disorder	contraindication	128613002
Metabolic syndrome X	contraindication	237602007	DOID:14221
Esophageal dysmotility	contraindication	266434009	DOID:9192
Neutropenic disorder	contraindication	303011007	DOID:1227
At risk for aspiration	contraindication	371736008
Impaired cognition	contraindication	386806002
Breastfeeding (mother)	contraindication	413712001
Myocardial ischemia	contraindication	414795007	DOID:3393
Obesity	contraindication	414916001	DOID:9970

🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation level	Dissociation constant	Type (acidic/basic)
pKa1	7.84	Basic
pKa2	0.67	Basic

Orange Book patent data (new drug applications)

Formulation strength	Trade name	Applicant	Application number	Approval date	Type	Dose form	Route	Patent number	Patent expiration date	Patent use
10MG	ABILIFY	OTSUKA	N021436	Nov. 15, 2002	RX	TABLET	ORAL	9125939	July 28, 2026	ACUTE TREATMENT OF MANIC AND MIXED EPISODES ASSOCIATED WITH BIPOLAR I DISORDER
15MG	ABILIFY	OTSUKA	N021436	Nov. 15, 2002	RX	TABLET	ORAL	9125939	July 28, 2026	ACUTE TREATMENT OF MANIC AND MIXED EPISODES ASSOCIATED WITH BIPOLAR I DISORDER
20MG	ABILIFY	OTSUKA	N021436	Nov. 15, 2002	RX	TABLET	ORAL	9125939	July 28, 2026	ACUTE TREATMENT OF MANIC AND MIXED EPISODES ASSOCIATED WITH BIPOLAR I DISORDER
2MG	ABILIFY	OTSUKA	N021436	Nov. 15, 2002	RX	TABLET	ORAL	9125939	July 28, 2026	ACUTE TREATMENT OF MANIC AND MIXED EPISODES ASSOCIATED WITH BIPOLAR I DISORDER
30MG	ABILIFY	OTSUKA	N021436	Nov. 15, 2002	RX	TABLET	ORAL	9125939	July 28, 2026	ACUTE TREATMENT OF MANIC AND MIXED EPISODES ASSOCIATED WITH BIPOLAR I DISORDER
5MG	ABILIFY	OTSUKA	N021436	Nov. 15, 2002	RX	TABLET	ORAL	9125939	July 28, 2026	ACUTE TREATMENT OF MANIC AND MIXED EPISODES ASSOCIATED WITH BIPOLAR I DISORDER
10MG Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons	ABILIFY	OTSUKA	N021729	June 7, 2006	DISCN	TABLET, ORALLY DISINTEGRATING	ORAL	9125939	July 28, 2026	ACUTE TREATMENT OF MANIC AND MIXED EPISODES ASSOCIATED WITH BIPOLAR I DISORDER
15MG Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons	ABILIFY	OTSUKA	N021729	June 7, 2006	DISCN	TABLET, ORALLY DISINTEGRATING	ORAL	9125939	July 28, 2026	ACUTE TREATMENT OF MANIC AND MIXED EPISODES ASSOCIATED WITH BIPOLAR I DISORDER
10MG	ABILIFY MYCITE KIT	OTSUKA	N207202	Nov. 13, 2017	DISCN	TABLET	ORAL	9125939	July 28, 2026	ACUTE TREATMENT OF MANIC AND MIXED EPISODES ASSOCIATED WITH BIPOLAR I DISORDER
15MG	ABILIFY MYCITE KIT	OTSUKA	N207202	Nov. 13, 2017	DISCN	TABLET	ORAL	9125939	July 28, 2026	ACUTE TREATMENT OF MANIC AND MIXED EPISODES ASSOCIATED WITH BIPOLAR I DISORDER
20MG	ABILIFY MYCITE KIT	OTSUKA	N207202	Nov. 13, 2017	DISCN	TABLET	ORAL	9125939	July 28, 2026	ACUTE TREATMENT OF MANIC AND MIXED EPISODES ASSOCIATED WITH BIPOLAR I DISORDER
2MG	ABILIFY MYCITE KIT	OTSUKA	N207202	Nov. 13, 2017	DISCN	TABLET	ORAL	9125939	July 28, 2026	ACUTE TREATMENT OF MANIC AND MIXED EPISODES ASSOCIATED WITH BIPOLAR I DISORDER
30MG	ABILIFY MYCITE KIT	OTSUKA	N207202	Nov. 13, 2017	DISCN	TABLET	ORAL	9125939	July 28, 2026	ACUTE TREATMENT OF MANIC AND MIXED EPISODES ASSOCIATED WITH BIPOLAR I DISORDER
5MG	ABILIFY MYCITE KIT	OTSUKA	N207202	Nov. 13, 2017	DISCN	TABLET	ORAL	9125939	July 28, 2026	ACUTE TREATMENT OF MANIC AND MIXED EPISODES ASSOCIATED WITH BIPOLAR I DISORDER
10MG	ABILIFY	OTSUKA	N021436	Nov. 15, 2002	RX	TABLET	ORAL	8759350	March 2, 2027	ADJUNCTIVE TREATMENT OF MAJOR DEPRESSIVE DISORDER (MDD)
15MG	ABILIFY	OTSUKA	N021436	Nov. 15, 2002	RX	TABLET	ORAL	8759350	March 2, 2027	ADJUNCTIVE TREATMENT OF MAJOR DEPRESSIVE DISORDER (MDD)
20MG	ABILIFY	OTSUKA	N021436	Nov. 15, 2002	RX	TABLET	ORAL	8759350	March 2, 2027	ADJUNCTIVE TREATMENT OF MAJOR DEPRESSIVE DISORDER (MDD)
2MG	ABILIFY	OTSUKA	N021436	Nov. 15, 2002	RX	TABLET	ORAL	8759350	March 2, 2027	ADJUNCTIVE TREATMENT OF MAJOR DEPRESSIVE DISORDER (MDD)
30MG	ABILIFY	OTSUKA	N021436	Nov. 15, 2002	RX	TABLET	ORAL	8759350	March 2, 2027	ADJUNCTIVE TREATMENT OF MAJOR DEPRESSIVE DISORDER (MDD)
5MG	ABILIFY	OTSUKA	N021436	Nov. 15, 2002	RX	TABLET	ORAL	8759350	March 2, 2027	ADJUNCTIVE TREATMENT OF MAJOR DEPRESSIVE DISORDER (MDD)
1MG/ML Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons	ABILIFY	OTSUKA	N021713	Dec. 10, 2004	DISCN	SOLUTION	ORAL	8759350	March 2, 2027	ADJUNCTIVE TREATMENT OF MAJOR DEPRESSIVE DISORDER (MDD)
10MG Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons	ABILIFY	OTSUKA	N021729	June 7, 2006	DISCN	TABLET, ORALLY DISINTEGRATING	ORAL	8759350	March 2, 2027	ADJUNCTIVE TREATMENT OF MAJOR DEPRESSIVE DISORDER (MDD)
15MG Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons	ABILIFY	OTSUKA	N021729	June 7, 2006	DISCN	TABLET, ORALLY DISINTEGRATING	ORAL	8759350	March 2, 2027	ADJUNCTIVE TREATMENT OF MAJOR DEPRESSIVE DISORDER (MDD)
10MG	ABILIFY MYCITE KIT	OTSUKA	N207202	Nov. 13, 2017	DISCN	TABLET	ORAL	8759350	March 2, 2027	ADJUNCTIVE TREATMENT OF MAJOR DEPRESSIVE DISORDER (MDD)
15MG	ABILIFY MYCITE KIT	OTSUKA	N207202	Nov. 13, 2017	DISCN	TABLET	ORAL	8759350	March 2, 2027	ADJUNCTIVE TREATMENT OF MAJOR DEPRESSIVE DISORDER (MDD)
20MG	ABILIFY MYCITE KIT	OTSUKA	N207202	Nov. 13, 2017	DISCN	TABLET	ORAL	8759350	March 2, 2027	ADJUNCTIVE TREATMENT OF MAJOR DEPRESSIVE DISORDER (MDD)
2MG	ABILIFY MYCITE KIT	OTSUKA	N207202	Nov. 13, 2017	DISCN	TABLET	ORAL	8759350	March 2, 2027	ADJUNCTIVE TREATMENT OF MAJOR DEPRESSIVE DISORDER (MDD)
30MG	ABILIFY MYCITE KIT	OTSUKA	N207202	Nov. 13, 2017	DISCN	TABLET	ORAL	8759350	March 2, 2027	ADJUNCTIVE TREATMENT OF MAJOR DEPRESSIVE DISORDER (MDD)
5MG	ABILIFY MYCITE KIT	OTSUKA	N207202	Nov. 13, 2017	DISCN	TABLET	ORAL	8759350	March 2, 2027	ADJUNCTIVE TREATMENT OF MAJOR DEPRESSIVE DISORDER (MDD)
10MG	ABILIFY MYCITE KIT	OTSUKA	N207202	Nov. 13, 2017	DISCN	TABLET	ORAL	9444503	Nov. 19, 2027	METHOD OF USING A RECEIVER TO IDENTIFY A SIGNAL FROM A TABLET EMBEDDED WITH A SENSOR THAT COMMUNICATES INFORMATION THROUGH THE BODY OF A PATIENT
15MG	ABILIFY MYCITE KIT	OTSUKA	N207202	Nov. 13, 2017	DISCN	TABLET	ORAL	9444503	Nov. 19, 2027	METHOD OF USING A RECEIVER TO IDENTIFY A SIGNAL FROM A TABLET EMBEDDED WITH A SENSOR THAT COMMUNICATES INFORMATION THROUGH THE BODY OF A PATIENT
20MG	ABILIFY MYCITE KIT	OTSUKA	N207202	Nov. 13, 2017	DISCN	TABLET	ORAL	9444503	Nov. 19, 2027	METHOD OF USING A RECEIVER TO IDENTIFY A SIGNAL FROM A TABLET EMBEDDED WITH A SENSOR THAT COMMUNICATES INFORMATION THROUGH THE BODY OF A PATIENT
2MG	ABILIFY MYCITE KIT	OTSUKA	N207202	Nov. 13, 2017	DISCN	TABLET	ORAL	9444503	Nov. 19, 2027	METHOD OF USING A RECEIVER TO IDENTIFY A SIGNAL FROM A TABLET EMBEDDED WITH A SENSOR THAT COMMUNICATES INFORMATION THROUGH THE BODY OF A PATIENT
30MG	ABILIFY MYCITE KIT	OTSUKA	N207202	Nov. 13, 2017	DISCN	TABLET	ORAL	9444503	Nov. 19, 2027	METHOD OF USING A RECEIVER TO IDENTIFY A SIGNAL FROM A TABLET EMBEDDED WITH A SENSOR THAT COMMUNICATES INFORMATION THROUGH THE BODY OF A PATIENT
5MG	ABILIFY MYCITE KIT	OTSUKA	N207202	Nov. 13, 2017	DISCN	TABLET	ORAL	9444503	Nov. 19, 2027	METHOD OF USING A RECEIVER TO IDENTIFY A SIGNAL FROM A TABLET EMBEDDED WITH A SENSOR THAT COMMUNICATES INFORMATION THROUGH THE BODY OF A PATIENT
10MG	ABILIFY MYCITE KIT	OTSUKA	N207202	Nov. 13, 2017	DISCN	TABLET	ORAL	8674825	April 9, 2029	METHOD OF USING A RECEIVER TO RECEIVE A SIGNAL FROM A TABLET EMBEDDED WITH A SENSOR THAT COMMUNICATES INFORMATION THROUGH THE BODY OF A PATIENT
15MG	ABILIFY MYCITE KIT	OTSUKA	N207202	Nov. 13, 2017	DISCN	TABLET	ORAL	8674825	April 9, 2029	METHOD OF USING A RECEIVER TO RECEIVE A SIGNAL FROM A TABLET EMBEDDED WITH A SENSOR THAT COMMUNICATES INFORMATION THROUGH THE BODY OF A PATIENT
20MG	ABILIFY MYCITE KIT	OTSUKA	N207202	Nov. 13, 2017	DISCN	TABLET	ORAL	8674825	April 9, 2029	METHOD OF USING A RECEIVER TO RECEIVE A SIGNAL FROM A TABLET EMBEDDED WITH A SENSOR THAT COMMUNICATES INFORMATION THROUGH THE BODY OF A PATIENT
2MG	ABILIFY MYCITE KIT	OTSUKA	N207202	Nov. 13, 2017	DISCN	TABLET	ORAL	8674825	April 9, 2029	METHOD OF USING A RECEIVER TO RECEIVE A SIGNAL FROM A TABLET EMBEDDED WITH A SENSOR THAT COMMUNICATES INFORMATION THROUGH THE BODY OF A PATIENT
30MG	ABILIFY MYCITE KIT	OTSUKA	N207202	Nov. 13, 2017	DISCN	TABLET	ORAL	8674825	April 9, 2029	METHOD OF USING A RECEIVER TO RECEIVE A SIGNAL FROM A TABLET EMBEDDED WITH A SENSOR THAT COMMUNICATES INFORMATION THROUGH THE BODY OF A PATIENT
5MG	ABILIFY MYCITE KIT	OTSUKA	N207202	Nov. 13, 2017	DISCN	TABLET	ORAL	8674825	April 9, 2029	METHOD OF USING A RECEIVER TO RECEIVE A SIGNAL FROM A TABLET EMBEDDED WITH A SENSOR THAT COMMUNICATES INFORMATION THROUGH THE BODY OF A PATIENT
10MG	ABILIFY MYCITE KIT	OTSUKA	N207202	Nov. 13, 2017	DISCN	TABLET	ORAL	8956288	July 6, 2029	METHOD OF USING A TABLET EMBEDDED WITH A SENSOR THAT COMMUNICATES INFORMATION VIA A SIGNAL THROUGH THE BODY OF A PATIENT TO A RECEIVER
15MG	ABILIFY MYCITE KIT	OTSUKA	N207202	Nov. 13, 2017	DISCN	TABLET	ORAL	8956288	July 6, 2029	METHOD OF USING A TABLET EMBEDDED WITH A SENSOR THAT COMMUNICATES INFORMATION VIA A SIGNAL THROUGH THE BODY OF A PATIENT TO A RECEIVER
20MG	ABILIFY MYCITE KIT	OTSUKA	N207202	Nov. 13, 2017	DISCN	TABLET	ORAL	8956288	July 6, 2029	METHOD OF USING A TABLET EMBEDDED WITH A SENSOR THAT COMMUNICATES INFORMATION VIA A SIGNAL THROUGH THE BODY OF A PATIENT TO A RECEIVER
2MG	ABILIFY MYCITE KIT	OTSUKA	N207202	Nov. 13, 2017	DISCN	TABLET	ORAL	8956288	July 6, 2029	METHOD OF USING A TABLET EMBEDDED WITH A SENSOR THAT COMMUNICATES INFORMATION VIA A SIGNAL THROUGH THE BODY OF A PATIENT TO A RECEIVER
30MG	ABILIFY MYCITE KIT	OTSUKA	N207202	Nov. 13, 2017	DISCN	TABLET	ORAL	8956288	July 6, 2029	METHOD OF USING A TABLET EMBEDDED WITH A SENSOR THAT COMMUNICATES INFORMATION VIA A SIGNAL THROUGH THE BODY OF A PATIENT TO A RECEIVER
5MG	ABILIFY MYCITE KIT	OTSUKA	N207202	Nov. 13, 2017	DISCN	TABLET	ORAL	8956288	July 6, 2029	METHOD OF USING A TABLET EMBEDDED WITH A SENSOR THAT COMMUNICATES INFORMATION VIA A SIGNAL THROUGH THE BODY OF A PATIENT TO A RECEIVER
10MG	ABILIFY MYCITE KIT	OTSUKA	N207202	Nov. 13, 2017	DISCN	TABLET	ORAL	8945005	Aug. 19, 2029	METHOD OF USING A TABLET EMBEDDED WITH A SENSOR THAT COMMUNICATES INFORMATION VIA A SIGNAL THROUGH THE BODY OF A PATIENT TO A RECEIVER
15MG	ABILIFY MYCITE KIT	OTSUKA	N207202	Nov. 13, 2017	DISCN	TABLET	ORAL	8945005	Aug. 19, 2029	METHOD OF USING A TABLET EMBEDDED WITH A SENSOR THAT COMMUNICATES INFORMATION VIA A SIGNAL THROUGH THE BODY OF A PATIENT TO A RECEIVER
20MG	ABILIFY MYCITE KIT	OTSUKA	N207202	Nov. 13, 2017	DISCN	TABLET	ORAL	8945005	Aug. 19, 2029	METHOD OF USING A TABLET EMBEDDED WITH A SENSOR THAT COMMUNICATES INFORMATION VIA A SIGNAL THROUGH THE BODY OF A PATIENT TO A RECEIVER
2MG	ABILIFY MYCITE KIT	OTSUKA	N207202	Nov. 13, 2017	DISCN	TABLET	ORAL	8945005	Aug. 19, 2029	METHOD OF USING A TABLET EMBEDDED WITH A SENSOR THAT COMMUNICATES INFORMATION VIA A SIGNAL THROUGH THE BODY OF A PATIENT TO A RECEIVER
30MG	ABILIFY MYCITE KIT	OTSUKA	N207202	Nov. 13, 2017	DISCN	TABLET	ORAL	8945005	Aug. 19, 2029	METHOD OF USING A TABLET EMBEDDED WITH A SENSOR THAT COMMUNICATES INFORMATION VIA A SIGNAL THROUGH THE BODY OF A PATIENT TO A RECEIVER
5MG	ABILIFY MYCITE KIT	OTSUKA	N207202	Nov. 13, 2017	DISCN	TABLET	ORAL	8945005	Aug. 19, 2029	METHOD OF USING A TABLET EMBEDDED WITH A SENSOR THAT COMMUNICATES INFORMATION VIA A SIGNAL THROUGH THE BODY OF A PATIENT TO A RECEIVER
10MG	ABILIFY MYCITE KIT	OTSUKA	N207202	Nov. 13, 2017	DISCN	TABLET	ORAL	8847766	March 29, 2030	METHOD OF USING A TABLET EMBEDDED WITH A SENSOR THAT COMMUNICATES INFORMATION VIA A SIGNAL THROUGH THE BODY OF A PATIENT TO A RECEIVER
15MG	ABILIFY MYCITE KIT	OTSUKA	N207202	Nov. 13, 2017	DISCN	TABLET	ORAL	8847766	March 29, 2030	METHOD OF USING A TABLET EMBEDDED WITH A SENSOR THAT COMMUNICATES INFORMATION VIA A SIGNAL THROUGH THE BODY OF A PATIENT TO A RECEIVER
20MG	ABILIFY MYCITE KIT	OTSUKA	N207202	Nov. 13, 2017	DISCN	TABLET	ORAL	8847766	March 29, 2030	METHOD OF USING A TABLET EMBEDDED WITH A SENSOR THAT COMMUNICATES INFORMATION VIA A SIGNAL THROUGH THE BODY OF A PATIENT TO A RECEIVER
2MG	ABILIFY MYCITE KIT	OTSUKA	N207202	Nov. 13, 2017	DISCN	TABLET	ORAL	8847766	March 29, 2030	METHOD OF USING A TABLET EMBEDDED WITH A SENSOR THAT COMMUNICATES INFORMATION VIA A SIGNAL THROUGH THE BODY OF A PATIENT TO A RECEIVER
30MG	ABILIFY MYCITE KIT	OTSUKA	N207202	Nov. 13, 2017	DISCN	TABLET	ORAL	8847766	March 29, 2030	METHOD OF USING A TABLET EMBEDDED WITH A SENSOR THAT COMMUNICATES INFORMATION VIA A SIGNAL THROUGH THE BODY OF A PATIENT TO A RECEIVER
5MG	ABILIFY MYCITE KIT	OTSUKA	N207202	Nov. 13, 2017	DISCN	TABLET	ORAL	8847766	March 29, 2030	METHOD OF USING A TABLET EMBEDDED WITH A SENSOR THAT COMMUNICATES INFORMATION VIA A SIGNAL THROUGH THE BODY OF A PATIENT TO A RECEIVER
10MG	ABILIFY MYCITE KIT	OTSUKA	N207202	Nov. 13, 2017	DISCN	TABLET	ORAL	8547248	Dec. 18, 2030	METHOD OF USING A TABLET EMBEDDED WITH A SENSOR THAT COMMUNICATES INFORMATION VIA A SIGNAL THROUGH THE BODY OF A PATIENT TO A RECEIVER
15MG	ABILIFY MYCITE KIT	OTSUKA	N207202	Nov. 13, 2017	DISCN	TABLET	ORAL	8547248	Dec. 18, 2030	METHOD OF USING A TABLET EMBEDDED WITH A SENSOR THAT COMMUNICATES INFORMATION VIA A SIGNAL THROUGH THE BODY OF A PATIENT TO A RECEIVER
20MG	ABILIFY MYCITE KIT	OTSUKA	N207202	Nov. 13, 2017	DISCN	TABLET	ORAL	8547248	Dec. 18, 2030	METHOD OF USING A TABLET EMBEDDED WITH A SENSOR THAT COMMUNICATES INFORMATION VIA A SIGNAL THROUGH THE BODY OF A PATIENT TO A RECEIVER
2MG	ABILIFY MYCITE KIT	OTSUKA	N207202	Nov. 13, 2017	DISCN	TABLET	ORAL	8547248	Dec. 18, 2030	METHOD OF USING A TABLET EMBEDDED WITH A SENSOR THAT COMMUNICATES INFORMATION VIA A SIGNAL THROUGH THE BODY OF A PATIENT TO A RECEIVER
30MG	ABILIFY MYCITE KIT	OTSUKA	N207202	Nov. 13, 2017	DISCN	TABLET	ORAL	8547248	Dec. 18, 2030	METHOD OF USING A TABLET EMBEDDED WITH A SENSOR THAT COMMUNICATES INFORMATION VIA A SIGNAL THROUGH THE BODY OF A PATIENT TO A RECEIVER
5MG	ABILIFY MYCITE KIT	OTSUKA	N207202	Nov. 13, 2017	DISCN	TABLET	ORAL	8547248	Dec. 18, 2030	METHOD OF USING A TABLET EMBEDDED WITH A SENSOR THAT COMMUNICATES INFORMATION VIA A SIGNAL THROUGH THE BODY OF A PATIENT TO A RECEIVER
720MG/2.4ML (300MG/ML)	ABILIFY ASIMTUFII	OTSUKA	N217006	April 27, 2023	RX	SUSPENSION, EXTENDED RELEASE	INTRAMUSCULAR	10517951	April 23, 2033	MAINTENANCE MONOTHERAPY TREATMENT OF BIPOLAR I DISORDER
720MG/2.4ML (300MG/ML)	ABILIFY ASIMTUFII	OTSUKA	N217006	April 27, 2023	RX	SUSPENSION, EXTENDED RELEASE	INTRAMUSCULAR	10517951	April 23, 2033	TREATMENT OF SCHIZOPHRENIA
720MG/2.4ML (300MG/ML)	ABILIFY ASIMTUFII	OTSUKA	N217006	April 27, 2023	RX	SUSPENSION, EXTENDED RELEASE	INTRAMUSCULAR	11097007	April 23, 2033	MAINTENANCE MONOTHERAPY TREATMENT OF BIPOLAR I DISORDER
720MG/2.4ML (300MG/ML)	ABILIFY ASIMTUFII	OTSUKA	N217006	April 27, 2023	RX	SUSPENSION, EXTENDED RELEASE	INTRAMUSCULAR	11097007	April 23, 2033	TREATMENT OF SCHIZOPHRENIA
720MG/2.4ML (300MG/ML)	ABILIFY ASIMTUFII	OTSUKA	N217006	April 27, 2023	RX	SUSPENSION, EXTENDED RELEASE	INTRAMUSCULAR	11638757	April 23, 2033	MAINTENANCE MONOTHERAPY TREATMENT OF BIPOLAR I DISORDER
720MG/2.4ML (300MG/ML)	ABILIFY ASIMTUFII	OTSUKA	N217006	April 27, 2023	RX	SUSPENSION, EXTENDED RELEASE	INTRAMUSCULAR	11638757	April 23, 2033	TREATMENT OF SCHIZOPHRENIA
720MG/2.4ML (300MG/ML)	ABILIFY ASIMTUFII	OTSUKA	N217006	April 27, 2023	RX	SUSPENSION, EXTENDED RELEASE	INTRAMUSCULAR	12016927	April 23, 2033	MAINTENANCE MONOTHERAPY TREATMENT OF BIPOLAR I DISORDER
720MG/2.4ML (300MG/ML)	ABILIFY ASIMTUFII	OTSUKA	N217006	April 27, 2023	RX	SUSPENSION, EXTENDED RELEASE	INTRAMUSCULAR	12016927	April 23, 2033	TREATMENT OF SCHIZOPHRENIA
960MG/3.2ML (300MG/ML)	ABILIFY ASIMTUFII	OTSUKA	N217006	April 27, 2023	RX	SUSPENSION, EXTENDED RELEASE	INTRAMUSCULAR	10517951	April 23, 2033	MAINTENANCE MONOTHERAPY TREATMENT OF BIPOLAR I DISORDER
960MG/3.2ML (300MG/ML)	ABILIFY ASIMTUFII	OTSUKA	N217006	April 27, 2023	RX	SUSPENSION, EXTENDED RELEASE	INTRAMUSCULAR	10517951	April 23, 2033	TREATMENT OF SCHIZOPHRENIA
960MG/3.2ML (300MG/ML)	ABILIFY ASIMTUFII	OTSUKA	N217006	April 27, 2023	RX	SUSPENSION, EXTENDED RELEASE	INTRAMUSCULAR	11097007	April 23, 2033	MAINTENANCE MONOTHERAPY TREATMENT OF BIPOLAR I DISORDER
960MG/3.2ML (300MG/ML)	ABILIFY ASIMTUFII	OTSUKA	N217006	April 27, 2023	RX	SUSPENSION, EXTENDED RELEASE	INTRAMUSCULAR	11097007	April 23, 2033	TREATMENT OF SCHIZOPHRENIA
960MG/3.2ML (300MG/ML)	ABILIFY ASIMTUFII	OTSUKA	N217006	April 27, 2023	RX	SUSPENSION, EXTENDED RELEASE	INTRAMUSCULAR	11638757	April 23, 2033	MAINTENANCE MONOTHERAPY TREATMENT OF BIPOLAR I DISORDER
960MG/3.2ML (300MG/ML)	ABILIFY ASIMTUFII	OTSUKA	N217006	April 27, 2023	RX	SUSPENSION, EXTENDED RELEASE	INTRAMUSCULAR	11638757	April 23, 2033	TREATMENT OF SCHIZOPHRENIA
960MG/3.2ML (300MG/ML)	ABILIFY ASIMTUFII	OTSUKA	N217006	April 27, 2023	RX	SUSPENSION, EXTENDED RELEASE	INTRAMUSCULAR	12016927	April 23, 2033	MAINTENANCE MONOTHERAPY TREATMENT OF BIPOLAR I DISORDER
960MG/3.2ML (300MG/ML)	ABILIFY ASIMTUFII	OTSUKA	N217006	April 27, 2023	RX	SUSPENSION, EXTENDED RELEASE	INTRAMUSCULAR	12016927	April 23, 2033	TREATMENT OF SCHIZOPHRENIA
300MG	ABILIFY MAINTENA KIT	OTSUKA PHARM CO LTD	N202971	Sept. 29, 2014	RX	FOR SUSPENSION, EXTENDED RELEASE	INTRAMUSCULAR	10980803	Sept. 24, 2033	TREATMENT OF SCHIZOPHRENIA
300MG	ABILIFY MAINTENA KIT	OTSUKA PHARM CO LTD	N202971	Sept. 29, 2014	RX	FOR SUSPENSION, EXTENDED RELEASE	INTRAMUSCULAR	10980803	Sept. 24, 2033	TREATMENT OF SCHIZOPHRENIA, WITH EFFICACY IN TREATING ACUTE EPISODES OF SCHIZOPHRENIA
300MG	ABILIFY MAINTENA KIT	OTSUKA PHARM CO LTD	N202971	Sept. 29, 2014	RX	FOR SUSPENSION, EXTENDED RELEASE	INTRAMUSCULAR	11154553	Sept. 24, 2033	MAINTENANCE MONOTHERAPY TREATMENT OF BIPOLAR I DISORDER
300MG	ABILIFY MAINTENA KIT	OTSUKA PHARM CO LTD	N202971	Sept. 29, 2014	RX	FOR SUSPENSION, EXTENDED RELEASE	INTRAMUSCULAR	11154553	Sept. 24, 2033	TREATMENT OF SCHIZOPHRENIA
300MG	ABILIFY MAINTENA KIT	OTSUKA PHARM CO LTD	N202971	Sept. 29, 2014	RX	FOR SUSPENSION, EXTENDED RELEASE	INTRAMUSCULAR	11154553	Sept. 24, 2033	TREATMENT OF SCHIZOPHRENIA, WITH EFFICACY IN TREATING ACUTE EPISODES OF SCHIZOPHRENIA
300MG	ABILIFY MAINTENA KIT	OTSUKA PHARM CO LTD	N202971	Sept. 29, 2014	RX	FOR SUSPENSION, EXTENDED RELEASE	INTRAMUSCULAR	11344547	Sept. 24, 2033	MAINTENANCE MONOTHERAPY TREATMENT OF BIPOLAR I DISORDER
300MG	ABILIFY MAINTENA KIT	OTSUKA PHARM CO LTD	N202971	Sept. 29, 2014	RX	FOR SUSPENSION, EXTENDED RELEASE	INTRAMUSCULAR	11344547	Sept. 24, 2033	TREATMENT OF SCHIZOPHRENIA
300MG	ABILIFY MAINTENA KIT	OTSUKA PHARM CO LTD	N202971	Sept. 29, 2014	RX	FOR SUSPENSION, EXTENDED RELEASE	INTRAMUSCULAR	11344547	Sept. 24, 2033	TREATMENT OF SCHIZOPHRENIA, WITH EFFICACY IN TREATING ACUTE EPISODES OF SCHIZOPHRENIA
300MG	ABILIFY MAINTENA KIT	OTSUKA PHARM CO LTD	N202971	Sept. 29, 2014	RX	FOR SUSPENSION, EXTENDED RELEASE	INTRAMUSCULAR	11400087	Sept. 24, 2033	MAINTENANCE MONOTHERAPY TREATMENT OF BIPOLAR I DISORDER
300MG	ABILIFY MAINTENA KIT	OTSUKA PHARM CO LTD	N202971	Sept. 29, 2014	RX	FOR SUSPENSION, EXTENDED RELEASE	INTRAMUSCULAR	11400087	Sept. 24, 2033	TREATMENT OF SCHIZOPHRENIA
300MG	ABILIFY MAINTENA KIT	OTSUKA PHARM CO LTD	N202971	Sept. 29, 2014	RX	FOR SUSPENSION, EXTENDED RELEASE	INTRAMUSCULAR	11400087	Sept. 24, 2033	TREATMENT OF SCHIZOPHRENIA, WITH EFFICACY IN TREATING ACUTE EPISODES OF SCHIZOPHRENIA
300MG/VIAL	ABILIFY MAINTENA KIT	OTSUKA PHARM CO LTD	N202971	Feb. 28, 2013	RX	FOR SUSPENSION, EXTENDED RELEASE	INTRAMUSCULAR	10980803	Sept. 24, 2033	TREATMENT OF SCHIZOPHRENIA
300MG/VIAL	ABILIFY MAINTENA KIT	OTSUKA PHARM CO LTD	N202971	Feb. 28, 2013	RX	FOR SUSPENSION, EXTENDED RELEASE	INTRAMUSCULAR	10980803	Sept. 24, 2033	TREATMENT OF SCHIZOPHRENIA, WITH EFFICACY IN TREATING ACUTE EPISODES OF SCHIZOPHRENIA
300MG/VIAL	ABILIFY MAINTENA KIT	OTSUKA PHARM CO LTD	N202971	Feb. 28, 2013	RX	FOR SUSPENSION, EXTENDED RELEASE	INTRAMUSCULAR	11154553	Sept. 24, 2033	MAINTENANCE MONOTHERAPY TREATMENT OF BIPOLAR I DISORDER
300MG/VIAL	ABILIFY MAINTENA KIT	OTSUKA PHARM CO LTD	N202971	Feb. 28, 2013	RX	FOR SUSPENSION, EXTENDED RELEASE	INTRAMUSCULAR	11154553	Sept. 24, 2033	TREATMENT OF SCHIZOPHRENIA
300MG/VIAL	ABILIFY MAINTENA KIT	OTSUKA PHARM CO LTD	N202971	Feb. 28, 2013	RX	FOR SUSPENSION, EXTENDED RELEASE	INTRAMUSCULAR	11154553	Sept. 24, 2033	TREATMENT OF SCHIZOPHRENIA, WITH EFFICACY IN TREATING ACUTE EPISODES OF SCHIZOPHRENIA
300MG/VIAL	ABILIFY MAINTENA KIT	OTSUKA PHARM CO LTD	N202971	Feb. 28, 2013	RX	FOR SUSPENSION, EXTENDED RELEASE	INTRAMUSCULAR	11344547	Sept. 24, 2033	MAINTENANCE MONOTHERAPY TREATMENT OF BIPOLAR I DISORDER
300MG/VIAL	ABILIFY MAINTENA KIT	OTSUKA PHARM CO LTD	N202971	Feb. 28, 2013	RX	FOR SUSPENSION, EXTENDED RELEASE	INTRAMUSCULAR	11344547	Sept. 24, 2033	TREATMENT OF SCHIZOPHRENIA
300MG/VIAL	ABILIFY MAINTENA KIT	OTSUKA PHARM CO LTD	N202971	Feb. 28, 2013	RX	FOR SUSPENSION, EXTENDED RELEASE	INTRAMUSCULAR	11344547	Sept. 24, 2033	TREATMENT OF SCHIZOPHRENIA, WITH EFFICACY IN TREATING ACUTE EPISODES OF SCHIZOPHRENIA
300MG/VIAL	ABILIFY MAINTENA KIT	OTSUKA PHARM CO LTD	N202971	Feb. 28, 2013	RX	FOR SUSPENSION, EXTENDED RELEASE	INTRAMUSCULAR	11400087	Sept. 24, 2033	MAINTENANCE MONOTHERAPY TREATMENT OF BIPOLAR I DISORDER
300MG/VIAL	ABILIFY MAINTENA KIT	OTSUKA PHARM CO LTD	N202971	Feb. 28, 2013	RX	FOR SUSPENSION, EXTENDED RELEASE	INTRAMUSCULAR	11400087	Sept. 24, 2033	TREATMENT OF SCHIZOPHRENIA
300MG/VIAL	ABILIFY MAINTENA KIT	OTSUKA PHARM CO LTD	N202971	Feb. 28, 2013	RX	FOR SUSPENSION, EXTENDED RELEASE	INTRAMUSCULAR	11400087	Sept. 24, 2033	TREATMENT OF SCHIZOPHRENIA, WITH EFFICACY IN TREATING ACUTE EPISODES OF SCHIZOPHRENIA
400MG	ABILIFY MAINTENA KIT	OTSUKA PHARM CO LTD	N202971	Sept. 29, 2014	RX	FOR SUSPENSION, EXTENDED RELEASE	INTRAMUSCULAR	10980803	Sept. 24, 2033	TREATMENT OF SCHIZOPHRENIA
400MG	ABILIFY MAINTENA KIT	OTSUKA PHARM CO LTD	N202971	Sept. 29, 2014	RX	FOR SUSPENSION, EXTENDED RELEASE	INTRAMUSCULAR	10980803	Sept. 24, 2033	TREATMENT OF SCHIZOPHRENIA, WITH EFFICACY IN TREATING ACUTE EPISODES OF SCHIZOPHRENIA
400MG	ABILIFY MAINTENA KIT	OTSUKA PHARM CO LTD	N202971	Sept. 29, 2014	RX	FOR SUSPENSION, EXTENDED RELEASE	INTRAMUSCULAR	11154553	Sept. 24, 2033	MAINTENANCE MONOTHERAPY TREATMENT OF BIPOLAR I DISORDER
400MG	ABILIFY MAINTENA KIT	OTSUKA PHARM CO LTD	N202971	Sept. 29, 2014	RX	FOR SUSPENSION, EXTENDED RELEASE	INTRAMUSCULAR	11154553	Sept. 24, 2033	TREATMENT OF SCHIZOPHRENIA
400MG	ABILIFY MAINTENA KIT	OTSUKA PHARM CO LTD	N202971	Sept. 29, 2014	RX	FOR SUSPENSION, EXTENDED RELEASE	INTRAMUSCULAR	11154553	Sept. 24, 2033	TREATMENT OF SCHIZOPHRENIA, WITH EFFICACY IN TREATING ACUTE EPISODES OF SCHIZOPHRENIA
400MG	ABILIFY MAINTENA KIT	OTSUKA PHARM CO LTD	N202971	Sept. 29, 2014	RX	FOR SUSPENSION, EXTENDED RELEASE	INTRAMUSCULAR	11344547	Sept. 24, 2033	MAINTENANCE MONOTHERAPY TREATMENT OF BIPOLAR I DISORDER
400MG	ABILIFY MAINTENA KIT	OTSUKA PHARM CO LTD	N202971	Sept. 29, 2014	RX	FOR SUSPENSION, EXTENDED RELEASE	INTRAMUSCULAR	11344547	Sept. 24, 2033	TREATMENT OF SCHIZOPHRENIA
400MG	ABILIFY MAINTENA KIT	OTSUKA PHARM CO LTD	N202971	Sept. 29, 2014	RX	FOR SUSPENSION, EXTENDED RELEASE	INTRAMUSCULAR	11344547	Sept. 24, 2033	TREATMENT OF SCHIZOPHRENIA, WITH EFFICACY IN TREATING ACUTE EPISODES OF SCHIZOPHRENIA
400MG	ABILIFY MAINTENA KIT	OTSUKA PHARM CO LTD	N202971	Sept. 29, 2014	RX	FOR SUSPENSION, EXTENDED RELEASE	INTRAMUSCULAR	11400087	Sept. 24, 2033	MAINTENANCE MONOTHERAPY TREATMENT OF BIPOLAR I DISORDER
400MG	ABILIFY MAINTENA KIT	OTSUKA PHARM CO LTD	N202971	Sept. 29, 2014	RX	FOR SUSPENSION, EXTENDED RELEASE	INTRAMUSCULAR	11400087	Sept. 24, 2033	TREATMENT OF SCHIZOPHRENIA
400MG	ABILIFY MAINTENA KIT	OTSUKA PHARM CO LTD	N202971	Sept. 29, 2014	RX	FOR SUSPENSION, EXTENDED RELEASE	INTRAMUSCULAR	11400087	Sept. 24, 2033	TREATMENT OF SCHIZOPHRENIA, WITH EFFICACY IN TREATING ACUTE EPISODES OF SCHIZOPHRENIA
400MG/VIAL	ABILIFY MAINTENA KIT	OTSUKA PHARM CO LTD	N202971	Feb. 28, 2013	RX	FOR SUSPENSION, EXTENDED RELEASE	INTRAMUSCULAR	10980803	Sept. 24, 2033	TREATMENT OF SCHIZOPHRENIA
400MG/VIAL	ABILIFY MAINTENA KIT	OTSUKA PHARM CO LTD	N202971	Feb. 28, 2013	RX	FOR SUSPENSION, EXTENDED RELEASE	INTRAMUSCULAR	10980803	Sept. 24, 2033	TREATMENT OF SCHIZOPHRENIA, WITH EFFICACY IN TREATING ACUTE EPISODES OF SCHIZOPHRENIA
400MG/VIAL	ABILIFY MAINTENA KIT	OTSUKA PHARM CO LTD	N202971	Feb. 28, 2013	RX	FOR SUSPENSION, EXTENDED RELEASE	INTRAMUSCULAR	11154553	Sept. 24, 2033	MAINTENANCE MONOTHERAPY TREATMENT OF BIPOLAR I DISORDER
400MG/VIAL	ABILIFY MAINTENA KIT	OTSUKA PHARM CO LTD	N202971	Feb. 28, 2013	RX	FOR SUSPENSION, EXTENDED RELEASE	INTRAMUSCULAR	11154553	Sept. 24, 2033	TREATMENT OF SCHIZOPHRENIA
400MG/VIAL	ABILIFY MAINTENA KIT	OTSUKA PHARM CO LTD	N202971	Feb. 28, 2013	RX	FOR SUSPENSION, EXTENDED RELEASE	INTRAMUSCULAR	11154553	Sept. 24, 2033	TREATMENT OF SCHIZOPHRENIA, WITH EFFICACY IN TREATING ACUTE EPISODES OF SCHIZOPHRENIA
400MG/VIAL	ABILIFY MAINTENA KIT	OTSUKA PHARM CO LTD	N202971	Feb. 28, 2013	RX	FOR SUSPENSION, EXTENDED RELEASE	INTRAMUSCULAR	11344547	Sept. 24, 2033	MAINTENANCE MONOTHERAPY TREATMENT OF BIPOLAR I DISORDER
400MG/VIAL	ABILIFY MAINTENA KIT	OTSUKA PHARM CO LTD	N202971	Feb. 28, 2013	RX	FOR SUSPENSION, EXTENDED RELEASE	INTRAMUSCULAR	11344547	Sept. 24, 2033	TREATMENT OF SCHIZOPHRENIA
400MG/VIAL	ABILIFY MAINTENA KIT	OTSUKA PHARM CO LTD	N202971	Feb. 28, 2013	RX	FOR SUSPENSION, EXTENDED RELEASE	INTRAMUSCULAR	11344547	Sept. 24, 2033	TREATMENT OF SCHIZOPHRENIA, WITH EFFICACY IN TREATING ACUTE EPISODES OF SCHIZOPHRENIA
400MG/VIAL	ABILIFY MAINTENA KIT	OTSUKA PHARM CO LTD	N202971	Feb. 28, 2013	RX	FOR SUSPENSION, EXTENDED RELEASE	INTRAMUSCULAR	11400087	Sept. 24, 2033	MAINTENANCE MONOTHERAPY TREATMENT OF BIPOLAR I DISORDER
400MG/VIAL	ABILIFY MAINTENA KIT	OTSUKA PHARM CO LTD	N202971	Feb. 28, 2013	RX	FOR SUSPENSION, EXTENDED RELEASE	INTRAMUSCULAR	11400087	Sept. 24, 2033	TREATMENT OF SCHIZOPHRENIA
400MG/VIAL	ABILIFY MAINTENA KIT	OTSUKA PHARM CO LTD	N202971	Feb. 28, 2013	RX	FOR SUSPENSION, EXTENDED RELEASE	INTRAMUSCULAR	11400087	Sept. 24, 2033	TREATMENT OF SCHIZOPHRENIA, WITH EFFICACY IN TREATING ACUTE EPISODES OF SCHIZOPHRENIA
10MG	ABILIFY MYCITE KIT	OTSUKA	N207202	Nov. 13, 2017	DISCN	TABLET	ORAL	9268909	Oct. 15, 2033	METHOD OF USING A LOGIC CIRCUIT TO STABILIZE BATTERY VOLTAGE SUPPLIED TO A SENSOR EMBEDDED WITH A TABLET AND THAT COMMUNICATES INFORMATION VIA A SIGNAL THROUGH THE BODY OF A PATIENT TO A RECEIVER
15MG	ABILIFY MYCITE KIT	OTSUKA	N207202	Nov. 13, 2017	DISCN	TABLET	ORAL	9268909	Oct. 15, 2033	METHOD OF USING A LOGIC CIRCUIT TO STABILIZE BATTERY VOLTAGE SUPPLIED TO A SENSOR EMBEDDED WITH A TABLET AND THAT COMMUNICATES INFORMATION VIA A SIGNAL THROUGH THE BODY OF A PATIENT TO A RECEIVER
20MG	ABILIFY MYCITE KIT	OTSUKA	N207202	Nov. 13, 2017	DISCN	TABLET	ORAL	9268909	Oct. 15, 2033	METHOD OF USING A LOGIC CIRCUIT TO STABILIZE BATTERY VOLTAGE SUPPLIED TO A SENSOR EMBEDDED WITH A TABLET AND THAT COMMUNICATES INFORMATION VIA A SIGNAL THROUGH THE BODY OF A PATIENT TO A RECEIVER
2MG	ABILIFY MYCITE KIT	OTSUKA	N207202	Nov. 13, 2017	DISCN	TABLET	ORAL	9268909	Oct. 15, 2033	METHOD OF USING A LOGIC CIRCUIT TO STABILIZE BATTERY VOLTAGE SUPPLIED TO A SENSOR EMBEDDED WITH A TABLET AND THAT COMMUNICATES INFORMATION VIA A SIGNAL THROUGH THE BODY OF A PATIENT TO A RECEIVER
30MG	ABILIFY MYCITE KIT	OTSUKA	N207202	Nov. 13, 2017	DISCN	TABLET	ORAL	9268909	Oct. 15, 2033	METHOD OF USING A LOGIC CIRCUIT TO STABILIZE BATTERY VOLTAGE SUPPLIED TO A SENSOR EMBEDDED WITH A TABLET AND THAT COMMUNICATES INFORMATION VIA A SIGNAL THROUGH THE BODY OF A PATIENT TO A RECEIVER
5MG	ABILIFY MYCITE KIT	OTSUKA	N207202	Nov. 13, 2017	DISCN	TABLET	ORAL	9268909	Oct. 15, 2033	METHOD OF USING A LOGIC CIRCUIT TO STABILIZE BATTERY VOLTAGE SUPPLIED TO A SENSOR EMBEDDED WITH A TABLET AND THAT COMMUNICATES INFORMATION VIA A SIGNAL THROUGH THE BODY OF A PATIENT TO A RECEIVER
300MG	ABILIFY MAINTENA KIT	OTSUKA PHARM CO LTD	N202971	Sept. 29, 2014	RX	FOR SUSPENSION, EXTENDED RELEASE	INTRAMUSCULAR	10525057	March 8, 2034	MAINTENANCE MONOTHERAPY TREATMENT OF BIPOLAR 1 DISORDER
300MG	ABILIFY MAINTENA KIT	OTSUKA PHARM CO LTD	N202971	Sept. 29, 2014	RX	FOR SUSPENSION, EXTENDED RELEASE	INTRAMUSCULAR	10525057	March 8, 2034	TREATMENT OF SCHIZOPHRENIA
300MG	ABILIFY MAINTENA KIT	OTSUKA PHARM CO LTD	N202971	Sept. 29, 2014	RX	FOR SUSPENSION, EXTENDED RELEASE	INTRAMUSCULAR	10525057	March 8, 2034	TREATMENT OF SCHIZOPHRENIA, WITH EFFICACY IN TREATING ACUTE EPISODES OF SCHIZOPHRENIA
300MG/VIAL	ABILIFY MAINTENA KIT	OTSUKA PHARM CO LTD	N202971	Feb. 28, 2013	RX	FOR SUSPENSION, EXTENDED RELEASE	INTRAMUSCULAR	10525057	March 8, 2034	MAINTENANCE MONOTHERAPY TREATMENT OF BIPOLAR 1 DISORDER
300MG/VIAL	ABILIFY MAINTENA KIT	OTSUKA PHARM CO LTD	N202971	Feb. 28, 2013	RX	FOR SUSPENSION, EXTENDED RELEASE	INTRAMUSCULAR	10525057	March 8, 2034	TREATMENT OF SCHIZOPHRENIA
300MG/VIAL	ABILIFY MAINTENA KIT	OTSUKA PHARM CO LTD	N202971	Feb. 28, 2013	RX	FOR SUSPENSION, EXTENDED RELEASE	INTRAMUSCULAR	10525057	March 8, 2034	TREATMENT OF SCHIZOPHRENIA, WITH EFFICACY IN TREATING ACUTE EPISODES OF SCHIZOPHRENIA
400MG	ABILIFY MAINTENA KIT	OTSUKA PHARM CO LTD	N202971	Sept. 29, 2014	RX	FOR SUSPENSION, EXTENDED RELEASE	INTRAMUSCULAR	10525057	March 8, 2034	MAINTENANCE MONOTHERAPY TREATMENT OF BIPOLAR 1 DISORDER
400MG	ABILIFY MAINTENA KIT	OTSUKA PHARM CO LTD	N202971	Sept. 29, 2014	RX	FOR SUSPENSION, EXTENDED RELEASE	INTRAMUSCULAR	10525057	March 8, 2034	TREATMENT OF SCHIZOPHRENIA
400MG	ABILIFY MAINTENA KIT	OTSUKA PHARM CO LTD	N202971	Sept. 29, 2014	RX	FOR SUSPENSION, EXTENDED RELEASE	INTRAMUSCULAR	10525057	March 8, 2034	TREATMENT OF SCHIZOPHRENIA, WITH EFFICACY IN TREATING ACUTE EPISODES OF SCHIZOPHRENIA
400MG/VIAL	ABILIFY MAINTENA KIT	OTSUKA PHARM CO LTD	N202971	Feb. 28, 2013	RX	FOR SUSPENSION, EXTENDED RELEASE	INTRAMUSCULAR	10525057	March 8, 2034	MAINTENANCE MONOTHERAPY TREATMENT OF BIPOLAR 1 DISORDER
400MG/VIAL	ABILIFY MAINTENA KIT	OTSUKA PHARM CO LTD	N202971	Feb. 28, 2013	RX	FOR SUSPENSION, EXTENDED RELEASE	INTRAMUSCULAR	10525057	March 8, 2034	TREATMENT OF SCHIZOPHRENIA
400MG/VIAL	ABILIFY MAINTENA KIT	OTSUKA PHARM CO LTD	N202971	Feb. 28, 2013	RX	FOR SUSPENSION, EXTENDED RELEASE	INTRAMUSCULAR	10525057	March 8, 2034	TREATMENT OF SCHIZOPHRENIA, WITH EFFICACY IN TREATING ACUTE EPISODES OF SCHIZOPHRENIA

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

Target	Class	Pharos	UniProt	Action	Type	Activity value (-log[M])	Bioact source	MoA source
5-hydroxytryptamine receptor 2A	GPCR	P28223	5HT2A_HUMAN	ANTAGONIST	Ki	7.90	WOMBAT-PK	CHEMBL
D(2) dopamine receptor	GPCR	P14416	DRD2_HUMAN	PARTIAL AGONIST	Ki	8.71	WOMBAT-PK	CHEMBL
5-hydroxytryptamine receptor 1A	GPCR	P08908	5HT1A_HUMAN	PARTIAL AGONIST	Ki	8.15	WOMBAT-PK	DRUG LABEL
D(1A) dopamine receptor	GPCR	P21728	DRD1_HUMAN		Ki	6.06	PDSP
Alpha-2A adrenergic receptor	GPCR	P08913	ADA2A_HUMAN		Ki	7.13	PDSP
Potassium voltage-gated channel subfamily H member 2	Ion channel	Q12809	KCNH2_HUMAN		Ki	6.22	CHEMBL
Multidrug resistance protein 1	Transporter	P08183	MDR1_HUMAN		IC50	6.11	CHEMBL
Sodium-dependent serotonin transporter	Transporter	P31645	SC6A4_HUMAN		Ki	6.83	WOMBAT-PK
Sodium-dependent noradrenaline transporter	Transporter	P23975	SC6A2_HUMAN		Ki	5.68	PDSP
5-hydroxytryptamine receptor 2B	GPCR	P41595	5HT2B_HUMAN		Ki	9.44	PDSP
5-hydroxytryptamine receptor 2C	GPCR	P28335	5HT2C_HUMAN		Ki	7.36	WOMBAT-PK
5-hydroxytryptamine receptor 6	GPCR	P50406	5HT6R_HUMAN		Ki	6.51	WOMBAT-PK
5-hydroxytryptamine receptor 7	GPCR	P34969	5HT7R_HUMAN		Ki	7.69	WOMBAT-PK
Alpha-1A adrenergic receptor	GPCR	P35348	ADA1A_HUMAN		Ki	7.24	WOMBAT-PK
Alpha-2B adrenergic receptor	GPCR	P18089	ADA2B_HUMAN		Ki	6.99	PDSP
D(3) dopamine receptor	GPCR	P35462	DRD3_HUMAN		Ki	8.53	WOMBAT-PK
D(1B) dopamine receptor	GPCR	P21918	DRD5_HUMAN		Ki	5.68	PDSP
Histamine H1 receptor	GPCR	P35367	HRH1_HUMAN		Ki	7.22	WOMBAT-PK
Muscarinic acetylcholine receptor M1	GPCR	P11229	ACM1_HUMAN		Ki	5.17	PDSP
Muscarinic acetylcholine receptor M2	GPCR	P08172	ACM2_HUMAN		Ki	5.46	PDSP
Muscarinic acetylcholine receptor M3	GPCR	P20309	ACM3_HUMAN		Ki	5.33	PDSP
Muscarinic acetylcholine receptor M4	GPCR	P08173	ACM4_HUMAN		Ki	5.82	PDSP
Muscarinic acetylcholine receptor M5	GPCR	P08912	ACM5_HUMAN		Ki	5.63	PDSP
5-hydroxytryptamine receptor 1B	GPCR	P28222	5HT1B_HUMAN		Ki	6.10	WOMBAT-PK
5-hydroxytryptamine receptor 1D	GPCR	P28221	5HT1D_HUMAN		Ki	7.20	WOMBAT-PK
Alpha-2C adrenergic receptor	GPCR	P18825	ADA2C_HUMAN		Ki	7.42	PDSP
Sodium-dependent dopamine transporter	Transporter	Q01959	SC6A3_HUMAN		Ki	5.49	PDSP
D(4) dopamine receptor	GPCR	P21917	DRD4_HUMAN		Ki	6.65	WOMBAT-PK
Alpha-1B adrenergic receptor	GPCR	P35368	ADA1B_HUMAN		Ki	7.46	PDSP
5-hydroxytryptamine receptor 5A	GPCR	P47898	5HT5A_HUMAN		Ki	5.91	PDSP
5-hydroxytryptamine receptor 1E	GPCR	P28566	5HT1E_HUMAN		Ki	5.10	PDSP
Histamine H3 receptor	GPCR	Q9Y5N1	HRH3_HUMAN		Ki	5.63	CHEMBL
5-hydroxytryptamine receptor 3A	Ion channel	P46098	5HT3A_HUMAN		Ki	6.20	PDSP
Histone H1.0	Nuclear other	P07305	H10_HUMAN		Ki	7.55	CHEMBL
Beta-1 adrenergic receptor	GPCR	P08588	ADRB1_HUMAN		Ki	6.85	PDSP
Beta-2 adrenergic receptor	GPCR	P07550	ADRB2_HUMAN		Ki	6.79	PDSP
Histamine H1 receptor	GPCR		HRH1_CAVPO		Ki	7	CHEMBL
D(2) dopamine receptor	GPCR		DRD2_RAT		Ki	9.10	CHEMBL
5-hydroxytryptamine receptor 1A	GPCR		5HT1A_RAT		Ki	9.40	CHEMBL
Sodium-dependent serotonin transporter	Transporter		SC6A4_RAT		Ki	5.97	CHEMBL
5-hydroxytryptamine receptor 2A	GPCR		5HT2A_RAT		Ki	8.15	CHEMBL
5-hydroxytryptamine receptor 7	GPCR		5HT7R_RAT	AGONIST	Ki	7.80	IUPHAR
D(1A) dopamine receptor	GPCR		DRD1_RAT		Ki	9.10	CHEMBL
D(3) dopamine receptor	GPCR		DRD3_RAT		IC50	7.42	CHEMBL
D(4) dopamine receptor	GPCR		DRD4_RAT	ANTAGONIST	Ki	7.30	IUPHAR
5-hydroxytryptamine receptor 6	GPCR		5HT6R_RAT	AGONIST	Ki	6.80	IUPHAR
5-hydroxytryptamine receptor 2C	GPCR		5HT2C_RAT		IC50	7.59	CHEMBL

External reference:

ID	Source
4021367	VUID
N0000148786	NUI
D01164	KEGG_DRUG
352393	RXNORM
C0299792	UMLSCUI
CHEBI:31236	CHEBI
9SC	PDB_CHEM_ID
CHEMBL1112	ChEMBL_ID
D000068180	MESH_DESCRIPTOR_UI
DB01238	DRUGBANK_ID
34	IUPHAR_LIGAND_ID
7477	INN_ID
82VFR53I78	UNII
60795	PUBCHEM_CID
17034	MMSL
231328	MMSL
45384	MMSL
d04825	MMSL
4021367	VANDF
009852	NDDF
406784005	SNOMEDCT_US
406785006	SNOMEDCT_US
82VFR53I78	INXIGHT DRUGS

Pharmaceutical products:

Product	Category	Ingredients	NDC	Form	Quantity	Route	Marketing	Label
Aripiprazole	HUMAN PRESCRIPTION DRUG LABEL	1	0615-8375	TABLET	5 mg	ORAL	ANDA	32 sections
Aripiprazole	HUMAN PRESCRIPTION DRUG LABEL	1	0615-8524	TABLET	2 mg	ORAL	ANDA	31 sections
Aripiprazole	HUMAN PRESCRIPTION DRUG LABEL	1	0615-8525	TABLET	10 mg	ORAL	ANDA	31 sections
aripiprazole	HUMAN PRESCRIPTION DRUG LABEL	1	0904-6656	TABLET	5 mg	ORAL	ANDA	30 sections
aripiprazole	HUMAN PRESCRIPTION DRUG LABEL	1	0904-6656	TABLET	5 mg	ORAL	ANDA	30 sections
Aripiprazole	HUMAN PRESCRIPTION DRUG LABEL	1	0904-7366	TABLET	2 mg	ORAL	ANDA	30 sections
Aripiprazole	HUMAN PRESCRIPTION DRUG LABEL	1	0904-7367	TABLET	5 mg	ORAL	ANDA	30 sections
Aripiprazole	HUMAN PRESCRIPTION DRUG LABEL	1	0904-7368	TABLET	10 mg	ORAL	ANDA	30 sections
Aripiprazole	HUMAN PRESCRIPTION DRUG LABEL	1	0904-7369	TABLET	15 mg	ORAL	ANDA	30 sections
Aripiprazole	HUMAN PRESCRIPTION DRUG LABEL	1	0904-7370	TABLET	20 mg	ORAL	ANDA	30 sections
Aripiprazole	HUMAN PRESCRIPTION DRUG LABEL	1	0904-7371	TABLET	30 mg	ORAL	ANDA	30 sections
aripiprazole	HUMAN PRESCRIPTION DRUG LABEL	1	13668-216	TABLET	2 mg	ORAL	ANDA	30 sections
aripiprazole	HUMAN PRESCRIPTION DRUG LABEL	1	13668-217	TABLET	5 mg	ORAL	ANDA	30 sections
aripiprazole	HUMAN PRESCRIPTION DRUG LABEL	1	13668-218	TABLET	10 mg	ORAL	ANDA	30 sections
aripiprazole	HUMAN PRESCRIPTION DRUG LABEL	1	13668-219	TABLET	15 mg	ORAL	ANDA	30 sections
aripiprazole	HUMAN PRESCRIPTION DRUG LABEL	1	13668-220	TABLET	20 mg	ORAL	ANDA	30 sections
aripiprazole	HUMAN PRESCRIPTION DRUG LABEL	1	13668-221	TABLET	30 mg	ORAL	ANDA	30 sections
OPIPZA	HUMAN PRESCRIPTION DRUG LABEL	1	15370-401	FILM, SOLUBLE	2 mg	ORAL	NDA	38 sections
OPIPZA	HUMAN PRESCRIPTION DRUG LABEL	1	15370-402	FILM, SOLUBLE	5 mg	ORAL	NDA	38 sections
OPIPZA	HUMAN PRESCRIPTION DRUG LABEL	1	15370-403	FILM, SOLUBLE	10 mg	ORAL	NDA	38 sections
ABILIFY	HUMAN PRESCRIPTION DRUG LABEL	1	16590-323	TABLET	2 mg	ORAL	NDA	32 sections
ABILIFY	HUMAN PRESCRIPTION DRUG LABEL	1	16590-745	TABLET	5 mg	ORAL	NDA	32 sections
Aripiprazole	HUMAN PRESCRIPTION DRUG LABEL	1	16714-141	TABLET	2 mg	ORAL	ANDA	30 sections
Aripiprazole	HUMAN PRESCRIPTION DRUG LABEL	1	16714-142	TABLET	5 mg	ORAL	ANDA	30 sections
Aripiprazole	HUMAN PRESCRIPTION DRUG LABEL	1	16714-143	TABLET	10 mg	ORAL	ANDA	30 sections
Aripiprazole	HUMAN PRESCRIPTION DRUG LABEL	1	16714-144	TABLET	15 mg	ORAL	ANDA	30 sections
Aripiprazole	HUMAN PRESCRIPTION DRUG LABEL	1	16714-145	TABLET	20 mg	ORAL	ANDA	30 sections
Aripiprazole	HUMAN PRESCRIPTION DRUG LABEL	1	16714-146	TABLET	30 mg	ORAL	ANDA	30 sections
ARIPIPRAZOLE	HUMAN PRESCRIPTION DRUG LABEL	1	16729-278	TABLET	2 mg	ORAL	ANDA	31 sections
ARIPIPRAZOLE	HUMAN PRESCRIPTION DRUG LABEL	1	16729-278	TABLET	2 mg	ORAL	ANDA	31 sections

Ask DrugCentral

Your question

DrugCentral answer

About Ask DrugCentral

General architecture

Using the assistant

aripiprazole 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Description:

Drug dosage:

ADMET properties:

Predicted pharmacokinetic/toxicological properties (PK-AZ):

Approvals:

FDA Adverse Event Reporting System (Female)

FDA Adverse Event Reporting System (Male)

FDA Adverse Event Reporting System (Geriatric)

FDA Adverse Event Reporting System (Pediatric)

Pharmacologic Action:

Related Drugs by ATC class:

Drug Use | Suggest Off label Use Form| |View source of the data|

🐶 Veterinary Drug Use

🐶 Veterinary products

Acid dissociation constants calculated using MoKa v3.0.0

Orange Book patent data (new drug applications)

Orange Book exclusivity data (new drug applications)

Bioactivity Summary:

External reference:

Pharmaceutical products: