prenylamine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
2261 390-64-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • prenylamine lactate
  • prenylamine
  • DL-Prenylamine
A drug formerly used in the treatment of angina pectoris but superseded by less hazardous drugs. Prenylamine depletes myocardial catecholamine stores and has some calcium channel blocking activity. (From Martindale, The Extra Pharmacopoeia, 30th ed, p1406)
  • Molecular weight: 329.49
  • Formula: C24H27N
  • CLOGP: 5.80
  • LIPINSKI: 1
  • HAC: 1
  • HDO: 1
  • TPSA: 12.03
  • ALOGS: -6.97
  • ROTB: 8

Drug dosage:

DoseUnitRoute
0.12 g O

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C01DX02 CARDIOVASCULAR SYSTEM
CARDIAC THERAPY
VASODILATORS USED IN CARDIAC DISEASES
Other vasodilators used in cardiac diseases
ATC C01DX52 CARDIOVASCULAR SYSTEM
CARDIAC THERAPY
VASODILATORS USED IN CARDIAC DISEASES
Other vasodilators used in cardiac diseases
MeSH PA D018663 Adrenergic Agents
MeSH PA D002121 Calcium Channel Blockers
MeSH PA D000077264 Calcium-Regulating Hormones and Agents
MeSH PA D002317 Cardiovascular Agents
MeSH PA D049990 Membrane Transport Modulators
MeSH PA D018377 Neurotransmitter Agents
MeSH PA D014665 Vasodilator Agents

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.32 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Sodium channel alpha subunits; brain (Types I, II, III) Ion channel IC50 6.52 CHEMBL
Voltage-gated L-type calcium channel Ion channel Kd 6.68 CHEMBL
Calmodulin Cytosolic other Kd 6.30 CHEMBL

External reference:

IDSource
D02167 KEGG_DRUG
69-43-2 SECONDARY_CAS_RN
C0033059 UMLSCUI
CHEBI:8397 CHEBI
CHEMBL24072 ChEMBL_ID
DB04825 DRUGBANK_ID
D011299 MESH_DESCRIPTOR_UI
C053347 MESH_SUPPLEMENTAL_RECORD_UI
9801 PUBCHEM_CID
1196 INN_ID
K2OH82Z000 UNII
34407 RXNORM
004026 NDDF
004027 NDDF
387288001 SNOMEDCT_US
51908007 SNOMEDCT_US

Pharmaceutical products:

None