dilazep 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| 893 | 35898-87-4 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Coronary vasodilator with some antiarrhythmic activity.
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 0.10 | g | O |
ADMET properties:
None
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | C01DX10 | CARDIOVASCULAR SYSTEM CARDIAC THERAPY VASODILATORS USED IN CARDIAC DISEASES Other vasodilators used in cardiac diseases |
| MeSH PA | D002317 | Cardiovascular Agents |
| MeSH PA | D014665 | Vasodilator Agents |
| CHEBI has role | CHEBI:35620 | vasodilator agents |
| CHEBI has role | CHEBI:50427 | platelet aggregation inhibitors |
| CHEBI has role | CHEBI:77307 | cardioprotective agents |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 7.86 | Basic |
| pKa2 | 3.86 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Equilibrative nucleoside transporter 1 | Transporter | Ki | 9 | CHEMBL | |||||
| Sodium channel alpha subunits; brain (Types I, II, III) | Ion channel | IC50 | 6.22 | CHEMBL | |||||
| Equilibrative nucleoside transporter 2 | Transporter | IC50 | 5.06 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| D07843 | KEGG_DRUG |
| C0012367 | UMLSCUI |
| CHEBI:92842 | CHEBI |
| CHEMBL126075 | ChEMBL_ID |
| D004109 | MESH_DESCRIPTOR_UI |
| DB13715 | DRUGBANK_ID |
| 4717 | IUPHAR_LIGAND_ID |
| 2779 | INN_ID |
| 20153-98-4 | SECONDARY_CAS_RN |
| F8KLC2BD5Z | UNII |
| 3074 | PUBCHEM_CID |
| 8DZ | PDB_CHEM_ID |
| CHEMBL1256327 | ChEMBL_ID |
Pharmaceutical products:
None