dilazep Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
893 35898-87-4

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • dilazep
  • dilazep dihydrochloride
  • dilazep hydrochloride
  • dilazep HCl
Coronary vasodilator with some antiarrhythmic activity.
  • Molecular weight: 604.70
  • Formula: C31H44N2O10
  • CLOGP: 3.54
  • LIPINSKI: 2
  • HAC: 12
  • HDO: 0
  • TPSA: 114.46
  • ALOGS: -4.08
  • ROTB: 18

Drug dosage:

DoseUnitRoute
0.10 g O

ADMET properties:

None

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

Pharmacologic Action:

SourceCodeDescription
ATC C01DX10 CARDIOVASCULAR SYSTEM
CARDIAC THERAPY
VASODILATORS USED IN CARDIAC DISEASES
Other vasodilators used in cardiac diseases
MeSH PA D002317 Cardiovascular Agents
MeSH PA D014665 Vasodilator Agents
CHEBI has role CHEBI:35620 vasodilator
CHEBI has role CHEBI:50427 platelet aggregation inhibitors
CHEBI has role CHEBI:77307 cardioprotective agents

Drug Use (View source of the data)

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 7.86 Basic
pKa2 3.86 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Equilibrative nucleoside transporter 1 Transporter Ki 9 CHEMBL
Sodium channel alpha subunits; brain (Types I, II, III) Ion channel IC50 6.22 CHEMBL
Equilibrative nucleoside transporter 2 Unclassified IC50 5.06 CHEMBL

External reference:

IDSource
D07843 KEGG_DRUG
20153-98-4 SECONDARY_CAS_RN
C0012367 UMLSCUI
CHEBI:92842 CHEBI
8DZ PDB_CHEM_ID
CHEMBL126075 ChEMBL_ID
CHEMBL1256327 ChEMBL_ID
DB13715 DRUGBANK_ID
D004109 MESH_DESCRIPTOR_UI
3074 PUBCHEM_CID
4717 IUPHAR_LIGAND_ID
2779 INN_ID
F8KLC2BD5Z UNII

Pharmaceutical products:

None