heptaminol 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |

Stem definitionDrug idCAS RN
1361 372-66-7

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • heptaminol
  • 2-Amino-6-hydroxy-6-methylheptane
  • heptaminol hydrochloride
  • heptaminol HCl
An amino alcohol that has been used as a myocardial stimulant and vasodilator and to relieve bronchospasm. Its most common therapeutic use is in orthostatic hypotension. The mechanism of heptaminol's therapeutic actions is not well understood although it has been suggested to affect catecholamine release or calcium metabolism.
  • Molecular weight: 145.25
  • Formula: C8H19NO
  • CLOGP: 0.48
  • LIPINSKI: 0
  • HAC: 2
  • HDO: 2
  • TPSA: 46.25
  • ALOGS: -0.95
  • ROTB: 4

Drug dosage:

DoseUnitRoute
0.45 g O
0.45 g P

ADMET properties:

PropertyValueReference
Vd (Volume of distribution) 2.14 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 10.72 mL/min/kg Lombardo F, Berellini G, Obach RS
t_half (Half-life) 2.50 hours Lombardo F, Berellini G, Obach RS

Predicted pharmacokinetic/toxicological properties (PK-AZ):

PropertyDescriptionValueUnitConfidenceSimilarity
kinase-safety-class ACVR2A,ACVR2B,AXL,BRAF,BTK,CAMK2D,CDK4,CDK5,EIF2AK3,ERBB2,GRK2,ITK,JAK3,MAP2K6,MAPK7,NTRK2,PDK2,PDK4,PRKDC,TEK,TGFBR1,ZAP70 22
kinase-selectivity-class CAMK2D,EIF2AK3,GAK,IRAK1,IRAK3,IRAK4,LRRK2,MAP3K7,PDK1 9
pfas-class PFAS structural alert (1 = True, 0 = False) 0

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC C01DX08 CARDIOVASCULAR SYSTEM
CARDIAC THERAPY
VASODILATORS USED IN CARDIAC DISEASES
Other vasodilators used in cardiac diseases
CHEBI has role CHEBI:35554 cardiovascular drug

Related Drugs by ATC class:

C01DX Other vasodilators used in cardiac diseases 18 drugs
benziodaronecarbocromencinepazetcloridaroldilazepefloxateetafenonehexobendineimolamineitramin tosilatelinsidominemolsidomine show all 18 →

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 10.61 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
N0000166812 NUI
D07158 KEGG_DRUG
C0019223 UMLSCUI
CHEBI:754695 CHEBI
CHEMBL2111076 ChEMBL_ID
DB13574 DRUGBANK_ID
D006535 MESH_DESCRIPTOR_UI
3590 PUBCHEM_CID
2030 INN_ID
3DQS188SY5 UNII
236294 RXNORM
005587 NDDF
005589 NDDF
006399 NDDF
735155009 SNOMEDCT_US
96259006 SNOMEDCT_US
CHEMBL2107282 ChEMBL_ID
543-15-7 SECONDARY_CAS_RN

Pharmaceutical products:

None