pivmecillinam 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| antibiotics, 6-aminopenicillanic acid derivatives | 2219 | 32886-97-8 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Pivaloyloxymethyl ester of amdinocillin that is well absorbed orally, but broken down to amdinocillin in the intestinal mucosa. It is active against gram-negative organisms and used as for amdinocillin.
|
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 0.60 | g | O |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BA (Bioavailability) | 0 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Approvals:
None
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Hydronephrosis | 78.63 | 44.45 | 18 | 493 | 10644 | 63477867 |
| Abdominal pain | 49.38 | 44.45 | 30 | 481 | 293426 | 63195085 |
| Blood creatinine increased | 47.93 | 44.45 | 20 | 491 | 87824 | 63400687 |
| Hyperammonaemic encephalopathy | 46.27 | 44.45 | 9 | 502 | 2425 | 63486086 |
| Sepsis | 46.01 | 44.45 | 23 | 488 | 153100 | 63335411 |
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Hydronephrosis | 68.49 | 43.79 | 18 | 670 | 17436 | 79726264 |
| Abdominal pain | 58.42 | 43.79 | 38 | 650 | 389531 | 79354169 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | J01CA08 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE BETA-LACTAM ANTIBACTERIALS, PENICILLINS Penicillins with extended spectrum |
| MeSH PA | D000900 | Anti-Bacterial Agents |
| MeSH PA | D000890 | Anti-Infective Agents |
| MeSH PA | D000892 | Anti-Infective Agents, Urinary |
| CHEBI has role | CHEBI:35441 | antiinfective agents |
| CHEBI has role | CHEBI:36047 | antibacterial drugs |
| CHEBI has role | CHEBI:50266 | Prodrugs |
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 9.12 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| N0000167001 | NUI |
| D01499 | KEGG_DRUG |
| C0002436 | UMLSCUI |
| CHEBI:51210 | CHEBI |
| CHEMBL1650818 | ChEMBL_ID |
| DB01605 | DRUGBANK_ID |
| 10922 | IUPHAR_LIGAND_ID |
| 32887-03-9 | SECONDARY_CAS_RN |
| 115163 | PUBCHEM_CID |
| 102745 | RXNORM |
| 003927 | NDDF |
| 003928 | NDDF |
| 323782007 | SNOMEDCT_US |
| 387542008 | SNOMEDCT_US |
| 96064003 | SNOMEDCT_US |
| D000561 | MESH_DESCRIPTOR_UI |
| 3499 | INN_ID |
| 1WAM1OQ30B | UNII |
Pharmaceutical products:
None