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pivmecillinam 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| antibiotics, 6-aminopenicillanic acid derivatives | 2219 | 32886-97-8 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Pivaloyloxymethyl ester of amdinocillin that is well absorbed orally, but broken down to amdinocillin in the intestinal mucosa. It is active against gram-negative organisms and used as for amdinocillin.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 0.60 | g | O |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BA (Bioavailability) | 75 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2A,ACVR2B,AKT2,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,CHEK1,DDR1,DYRK1B,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,GSK3B,ITK,JAK2,MAP3K21,MAP3K7,MAPK10,MAPK7,MAPK9,MAPKAPK2,MARK4,MET,MTOR,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CB,PIM2,PLK1,PRKCD,PRKDC,SIK2,SIK3,STK33,SYK,TEK,TTK,ZAP70 | 48 | |||
| kinase-selectivity-class | AXL,BRAF,GRK2 | 3 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
None
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Hydronephrosis | 92.64 | 40.26 | 22 | 871 | 12380 | 90615174 |
| Blood creatinine increased | 56.82 | 40.26 | 25 | 868 | 101361 | 90526193 |
| Tubulointerstitial nephritis | 50.95 | 40.26 | 16 | 877 | 25327 | 90602227 |
| Abdominal pain | 50.78 | 40.26 | 37 | 856 | 395684 | 90231870 |
| Cytomegalovirus infection | 50.19 | 40.26 | 16 | 877 | 26586 | 90600968 |
| Sepsis | 48.68 | 40.26 | 27 | 866 | 179787 | 90447767 |
| Hyperammonaemic encephalopathy | 43.49 | 40.26 | 9 | 884 | 2690 | 90624864 |
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Hydronephrosis | 78.60 | 36.53 | 22 | 1218 | 20643 | 110567416 |
| Abdominal pain | 51.88 | 36.53 | 44 | 1196 | 512945 | 110075114 |
| Tubulointerstitial nephritis | 50.61 | 36.53 | 20 | 1220 | 54264 | 110533795 |
| Genital ulceration | 45.12 | 36.53 | 9 | 1231 | 1966 | 110586093 |
| Cytomegalovirus infection | 43.64 | 36.53 | 18 | 1222 | 54426 | 110533633 |
| Blood creatinine increased | 42.32 | 36.53 | 26 | 1214 | 182863 | 110405196 |
| Neutropenic infection | 40.67 | 36.53 | 9 | 1231 | 3236 | 110584823 |
| Constipation | 36.70 | 36.53 | 31 | 1209 | 357755 | 110230304 |
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | J01CA08 | ANTIINFECTIVES FOR SYSTEMIC USE ANTIBACTERIALS FOR SYSTEMIC USE BETA-LACTAM ANTIBACTERIALS, PENICILLINS Penicillins with extended spectrum |
| MeSH PA | D000890 | Anti-Infective Agents |
| MeSH PA | D000892 | Anti-Infective Agents, Urinary |
| MeSH PA | D000900 | Anti-Bacterial Agents |
| CHEBI has role | CHEBI:35441 | antiinfective agent |
| CHEBI has role | CHEBI:36047 | antibacterial drug |
| CHEBI has role | CHEBI:50266 | prodrug |
| CHEBI has role | CHEBI:33282 | antibacterial agent |
Related Drugs by ATC class:
J01CA Penicillins with extended spectrum 18 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 9.12 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| N0000167001 | NUI |
| D01499 | KEGG_DRUG |
| 4043568 | VANDF |
| C0002436 | UMLSCUI |
| CHEBI:51210 | CHEBI |
| CHEMBL1650818 | ChEMBL_ID |
| DB01605 | DRUGBANK_ID |
| 10922 | IUPHAR_LIGAND_ID |
| 32887-03-9 | SECONDARY_CAS_RN |
| 115163 | PUBCHEM_CID |
| 102745 | RXNORM |
| 15321 | MMSL |
| d04643 | MMSL |
| 003927 | NDDF |
| 003928 | NDDF |
| 323782007 | SNOMEDCT_US |
| 387542008 | SNOMEDCT_US |
| 96064003 | SNOMEDCT_US |
| D000561 | MESH_DESCRIPTOR_UI |
| 3499 | INN_ID |
| 1WAM1OQ30B | UNII |
| 1WAM1OQ30B | INXIGHT DRUGS |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| PIVYA | HUMAN PRESCRIPTION DRUG LABEL | 1 | 62332-966 | TABLET, COATED | 185 mg | ORAL | NDA | 29 sections |