pivmecillinam 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
antibiotics, 6-aminopenicillanic acid derivatives 2219 32886-97-8

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • pivmecillinam
  • amdinocillin pivoxil
  • pivamdinocillin
  • pivmecillinam hydrochloride
  • pivmecillinam HCl
Pivaloyloxymethyl ester of amdinocillin that is well absorbed orally, but broken down to amdinocillin in the intestinal mucosa. It is active against gram-negative organisms and used as for amdinocillin.
  • Molecular weight: 439.57
  • Formula: C21H33N3O5S
  • CLOGP: 3.96
  • LIPINSKI: 0
  • HAC: 8
  • HDO: 0
  • TPSA: 88.51
  • ALOGS: -3.92
  • ROTB: 7

Drug dosage:

DoseUnitRoute
0.60 g O

ADMET properties:

PropertyValueReference
BA (Bioavailability) 0 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H

Approvals:

None

FDA Adverse Event Reporting System (Female)

None

FDA Adverse Event Reporting System (Male)

None

FDA Adverse Event Reporting System (Geriatric)

None

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC J01CA08 ANTIINFECTIVES FOR SYSTEMIC USE
ANTIBACTERIALS FOR SYSTEMIC USE
BETA-LACTAM ANTIBACTERIALS, PENICILLINS
Penicillins with extended spectrum
MeSH PA D000900 Anti-Bacterial Agents
MeSH PA D000890 Anti-Infective Agents
MeSH PA D000892 Anti-Infective Agents, Urinary
CHEBI has role CHEBI:35441 antiinfective agents
CHEBI has role CHEBI:36047 antibacterial drugs
CHEBI has role CHEBI:50266 Prodrugs

Drug Use | Suggest Off label Use Form| |View source of the data|

None




🐶 Veterinary Drug Use

None

🐶 Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.12 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

None

External reference:

IDSource
N0000167001 NUI
D01499 KEGG_DRUG
C0002436 UMLSCUI
CHEBI:51210 CHEBI
CHEMBL1650818 ChEMBL_ID
DB01605 DRUGBANK_ID
10922 IUPHAR_LIGAND_ID
32887-03-9 SECONDARY_CAS_RN
115163 PUBCHEM_CID
102745 RXNORM
003927 NDDF
003928 NDDF
323782007 SNOMEDCT_US
387542008 SNOMEDCT_US
96064003 SNOMEDCT_US
D000561 MESH_DESCRIPTOR_UI
3499 INN_ID
1WAM1OQ30B UNII

Pharmaceutical products:

None