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nicomorphine 🐶 Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | PK/Tox | Related Drugs | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| opioid receptor antagonists/agonists, morphinan derivates | 1918 | 639-48-5 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 30 | mg | O |
| 30 | mg | P |
| 30 | mg | R |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BA (Bioavailability) | 24 % |
Predicted pharmacokinetic/toxicological properties (PK-AZ):
| Property | Description | Value | Unit | Confidence | Similarity |
|---|---|---|---|---|---|
| kinase-safety-class | ACVR2B,AKT3,AURKA,AXL,BRAF,BTK,CAMK2B,CAMK2D,CDK5,CDK9,DDR1,DYRK1B,EGFR,EIF2AK3,EPHB4,ERBB2,FLT3,GRK2,ITK,JAK2,JAK3,MAP3K21,MAP3K7,MAPK10,MAPK12,MAPK7,MAPKAPK2,MET,NTRK2,PDK1,PDK2,PDK4,PDPK1,PIK3CB,PIM2,PRKDC,SIK2,STK33,TEK,TTK | 40 | |||
| kinase-selectivity-class | AXL,BRAF,CDK9,EIF2AK3,EPHB4,ERBB2,GRK2 | 7 | |||
| pfas-class | PFAS structural alert (1 = True, 0 = False) | 0 |
Approvals:
None
FDA Adverse Event Reporting System (Female)
None
FDA Adverse Event Reporting System (Male)
None
FDA Adverse Event Reporting System (Geriatric)
None
FDA Adverse Event Reporting System (Pediatric)
None
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | N02AA04 | NERVOUS SYSTEM ANALGESICS OPIOIDS Natural opium alkaloids |
| MeSH PA | D000700 | Analgesics |
| MeSH PA | D002491 | Central Nervous System Agents |
| MeSH PA | D002492 | Central Nervous System Depressants |
| MeSH PA | D009294 | Narcotics |
| MeSH PA | D018373 | Peripheral Nervous System Agents |
| MeSH PA | D018689 | Sensory System Agents |
| MeSH PA | D000701 | Analgesics, Opioid |
| FDA MoA | N0000175684 | Full Opioid Agonists |
| FDA EPC | N0000175690 | Opioid Agonist |
| CHEBI has role | CHEBI:35482 | opioid analgesic |
| CHEBI has role | CHEBI:35620 | vasodilator agent |
| CHEBI has role | CHEBI:35703 | xenobiotic |
| CHEBI has role | CHEBI:38867 | anaesthetic |
| CHEBI has role | CHEBI:55322 | μ-opioid receptor agonist |
| CHEBI has role | CHEBI:76924 | plant metabolite |
| CHEBI has role | CHEBI:78298 | environmental contaminant |
| CHEBI has role | CHEBI:88188 | drug allergen |
| CHEBI has role | CHEBI:176497 | geroprotector |
| CHEBI has role | CHEBI:35480 | analgesic |
Related Drugs by ATC class:
N02AA Natural opium alkaloids 8 drugs
Drug Use | Suggest Off label Use Form| |View source of the data|
None
🐶 Veterinary Drug Use
None
🐶 Veterinary products
None
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 8.18 | Basic |
| pKa2 | 3.27 | Basic |
| pKa3 | 2.65 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
None
External reference:
| ID | Source |
|---|---|
| D07285 | KEGG_DRUG |
| 4017530 | VANDF |
| C0068699 | UMLSCUI |
| CHEBI:135797 | CHEBI |
| MOI | PDB_CHEM_ID |
| CHEMBL2106851 | ChEMBL_ID |
| DB13454 | DRUGBANK_ID |
| C008549 | MESH_SUPPLEMENTAL_RECORD_UI |
| 789 | INN_ID |
| Y95FRL95FW | UNII |
| 5362460 | PUBCHEM_CID |
| 7052 | RXNORM |
| d00308 | MMSL |
| 001545 | NDDF |
| 373529000 | SNOMEDCT_US |
| 73572009 | SNOMEDCT_US |
| 96181009 | SNOMEDCT_US |
| C0026549 | UMLSCUI |
| DB00295 | DRUGBANK_ID |
| 5288826 | PUBCHEM_CID |
| D009020 | MESH_DESCRIPTOR_UI |
| CHEBI:17303 | CHEBI |
| Y95FRL95FW | INXIGHT DRUGS |
Pharmaceutical products:
None