hydromorphone ๐Ÿถ Veterinary Use | Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |

Stem definitionDrug idCAS RN
opioid receptor antagonists/agonists, morphinan derivates 1393 466-99-9

Description:

MoleculeDescription

Molfile Inchi Smiles

Synonyms:

  • hydromorphone
  • dihydromorphinone
  • dihydromorphone
  • dimorphone
  • hydromorphon
  • hydromorphone hydrochloride
  • hydromorphone HCl
An opioid analgesic made from MORPHINE and used mainly as an analgesic. It has a shorter duration of action than morphine.
  • Molecular weight: 285.34
  • Formula: C17H19NO3
  • CLOGP: 0.72
  • LIPINSKI: 0
  • HAC: 4
  • HDO: 1
  • TPSA: 49.77
  • ALOGS: -1.81
  • ROTB: 0

  • Status: OFP

  • Legend:
    OFP - off patent
    OFM - off market
    ONP - on patent

Drug dosage:

DoseUnitRoute
20 mg O
4 mg P
4 mg R

ADMET properties:

PropertyValueReference
BDDCS (Biopharmaceutical Drug Disposition Classification System) 1 Benet LZ, Broccatelli F, Oprea TI
S (Water solubility) 10 mg/mL Benet LZ, Broccatelli F, Oprea TI
EoM (Fraction excreted unchanged in urine) 6 % Benet LZ, Broccatelli F, Oprea TI
MRTD (Maximum Recommended Therapeutic Daily Dose) 1.20 ยตM/kg/day Contrera JF, Matthews EJ, Kruhlak NL, Benz RD
BA (Bioavailability) 42 % Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H
Vd (Volume of distribution) 4.30 L/kg Lombardo F, Berellini G, Obach RS
CL (Clearance) 28 mL/min/kg Lombardo F, Berellini G, Obach RS
fu (Fraction unbound in plasma) 0.86 % Lombardo F, Berellini G, Obach RS
t_half (Half-life) 2.30 hours Lombardo F, Berellini G, Obach RS

Approvals:

DateAgencyCompanyOrphan
Jan. 11, 1984 FDA PURDUE PHARM PRODS

FDA Adverse Event Reporting System (Female)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug hypersensitivity 493.84 9.90 1255 88575 249755 50265539
Temperature regulation disorder 259.85 9.90 134 89696 4093 50511201
Food allergy 187.99 9.90 138 89692 7999 50507295
Coeliac disease 171.25 9.90 134 89696 8551 50506743
Pneumonia viral 164.91 9.90 119 89711 6715 50508579
Drug withdrawal syndrome 145.13 9.90 200 89630 24881 50490413
Pneumonia aspiration 138.64 9.90 219 89611 30785 50484509
Bursitis 137.95 9.90 183 89647 21952 50493342
Immunodeficiency 137.44 9.90 150 89680 14678 50500616
Constipation 131.94 9.90 665 89165 185043 50330251
Soft tissue disorder 131.53 9.90 86 89744 4128 50511166
Drug dependence 130.34 9.90 168 89662 19591 50495703
Macular degeneration 122.11 9.90 139 89691 14249 50501045
Alopecia 119.45 9.90 156 89674 244891 50270403
Somnolence 114.30 9.90 561 89269 154424 50360870
Pemphigus 106.52 9.90 40 89790 120126 50395168
Rheumatoid arthritis 90.77 9.90 643 89187 201907 50313387
Arthritis 89.99 9.90 348 89482 86373 50428921
Nausea 89.03 9.90 1749 88081 703649 49811645
Systemic lupus erythematosus 88.28 9.90 72 89758 140550 50374744
Glossodynia 87.57 9.90 48 89782 115521 50399773
Delirium 85.34 9.90 201 89629 37991 50477303
Hyperaesthesia 83.37 9.90 87 89743 8086 50507208
Maternal exposure during pregnancy 80.61 9.90 99 89731 159679 50355615
Respiratory rate decreased 72.44 9.90 53 89777 3055 50512239
Extremity contracture 72.23 9.90 38 89792 1210 50514084
Hypermobility syndrome 70.80 9.90 32 89798 725 50514569
Unresponsive to stimuli 70.47 9.90 163 89667 30446 50484848
Ankylosing spondylitis 69.05 9.90 74 89756 7091 50508203
Oral pain 68.63 9.90 143 89687 24890 50490404
Respiratory depression 68.31 9.90 95 89735 11915 50503379
Vomiting 68.21 9.90 1172 88658 459586 50055708
Back pain 67.98 9.90 642 89188 219388 50295906
Duodenal ulcer perforation 64.97 9.90 4 89826 45607 50469687
Lower respiratory tract infection 64.54 9.90 45 89785 95156 50420138
Gastrooesophageal reflux disease 61.60 9.90 284 89546 76144 50439150
Coma 58.78 9.90 228 89602 56651 50458643
Helicobacter infection 58.72 9.90 9 89821 49693 50465601
Overdose 56.48 9.90 336 89494 99391 50415903
Herpes zoster 56.28 9.90 262 89568 70524 50444770
Drug interaction 56.07 9.90 175 89655 199446 50315848
Injection site erythema 55.49 9.90 32 89798 74904 50440390
Abdominal discomfort 55.06 9.90 218 89612 231423 50283871
Rash erythematous 54.91 9.90 161 89669 34691 50480603
Pain 54.60 9.90 1378 88452 577525 49937769
Hyperhidrosis 54.35 9.90 307 89523 89119 50426175
Inadequate analgesia 53.77 9.90 41 89789 2517 50512777
Muscle injury 53.63 9.90 3 89827 37108 50478186
Rash 51.68 9.90 512 89318 436959 50078335
Malignant neoplasm progression 51.14 9.90 248 89582 67876 50447418
Sickle cell anaemia with crisis 51.14 9.90 51 89779 4492 50510802
Medical device site pain 50.79 9.90 17 89813 164 50515130
Device related thrombosis 49.11 9.90 30 89800 1277 50514017
Pericarditis 48.48 9.90 41 89789 78648 50436646
Narcotic bowel syndrome 47.85 9.90 15 89815 115 50515179
Anti-cyclic citrullinated peptide antibody positive 47.00 9.90 34 89796 70553 50444741
Joint dislocation 46.89 9.90 81 89749 12252 50503042
Hepatic cirrhosis 46.54 9.90 99 89731 17478 50497816
Drug diversion 46.29 9.90 24 89806 741 50514553
Exostosis 46.23 9.90 78 89752 11575 50503719
Breast cancer metastatic 46.03 9.90 73 89757 10291 50505003
Hand deformity 45.52 9.90 67 89763 100132 50415162
Intentional overdose 44.44 9.90 28 89802 62476 50452818
Implant site extravasation 44.17 9.90 20 89810 455 50514839
Irritable bowel syndrome 44.11 9.90 18 89812 51423 50463871
Retinitis 43.57 9.90 32 89798 1855 50513439
Neoplasm progression 43.38 9.90 132 89698 29025 50486269
Arthropathy 43.22 9.90 140 89690 157766 50357528
Exposure during pregnancy 43.21 9.90 94 89736 120921 50394373
Folliculitis 42.24 9.90 9 89821 39216 50476078
Hereditary angioedema 41.87 9.90 50 89780 5392 50509902
Migraine 40.93 9.90 251 89579 75029 50440265
Swelling 40.49 9.90 201 89629 200671 50314623
Sleep disorder due to general medical condition, insomnia type 38.77 9.90 5 89825 31442 50483852
Therapeutic product effect incomplete 38.30 9.90 286 89544 91229 50424065
Blister 37.94 9.90 58 89772 85360 50429934
Anaphylactic reaction 37.88 9.90 193 89637 53862 50461432
Postmortem blood drug level increased 37.36 9.90 19 89811 563 50514731
Asthma 37.28 9.90 279 89551 89058 50426236
Bone erosion 37.11 9.90 71 89759 11616 50503678
Osteoporosis 37.06 9.90 168 89662 44711 50470583
Fluid retention 37.01 9.90 183 89647 50466 50464828
Drug reaction with eosinophilia and systemic symptoms 36.33 9.90 4 89826 28420 50486874
Injection site pain 35.82 9.90 91 89739 110933 50404361
Myocardial infarction 35.33 9.90 65 89765 88962 50426332
Injection site swelling 35.20 9.90 15 89815 41758 50473536
Cardiac failure congestive 34.94 9.90 60 89770 84322 50430972
Scar 34.14 9.90 69 89761 11749 50503545
Rheumatoid factor negative 33.96 9.90 18 89812 582 50514712
Abortion spontaneous 33.63 9.90 16 89814 41756 50473538
Faecal volume decreased 33.21 9.90 12 89818 148 50515146
Pustular psoriasis 33.00 9.90 38 89792 3943 50511351
Product dose omission issue 32.59 9.90 192 89638 183646 50331648
Fibromyalgia 32.50 9.90 162 89668 44816 50470478
Hyponatraemia 32.43 9.90 77 89753 96062 50419232
Abdominal pain 32.34 9.90 594 89236 235634 50279660
Treatment failure 31.74 9.90 131 89699 137506 50377788
Hypertensive encephalopathy 31.59 9.90 17 89813 567 50514727
Alveolitis 31.43 9.90 30 89800 2504 50512790
Small intestinal obstruction 31.04 9.90 80 89750 15988 50499306
Overwork 30.75 9.90 9 89821 53 50515241
Tenderness 30.43 9.90 87 89743 18478 50496816
Neutropenia 29.83 9.90 148 89682 147817 50367477
Acute chest syndrome 29.72 9.90 17 89813 640 50514654
Drug abuse 29.71 9.90 195 89635 59651 50455643
Injection site reaction 29.69 9.90 27 89803 50005 50465289
Compartment syndrome 29.52 9.90 26 89804 1956 50513338
Plasma cell myeloma 29.50 9.90 122 89708 31200 50484094
Mental status changes 29.36 9.90 135 89695 36137 50479157
Synovitis 29.04 9.90 342 89488 123523 50391771
Injection site pruritus 28.86 9.90 18 89812 40393 50474901
Hepatic function abnormal 28.73 9.90 11 89819 32670 50482624
Hepatitis 28.65 9.90 10 89820 31443 50483851
Renal impairment 28.49 9.90 57 89773 75604 50439690
Obstruction 28.11 9.90 26 89804 2085 50513209
Head banging 27.96 9.90 14 89816 401 50514893
Hypoaesthesia 27.93 9.90 347 89483 126910 50388384
Interstitial lung disease 27.80 9.90 32 89798 53144 50462150
Sinusitis 27.71 9.90 183 89647 170375 50344919
Immunoglobulins decreased 27.65 9.90 19 89811 991 50514303
Rhesus antigen positive 27.63 9.90 10 89820 124 50515170
Blepharospasm 27.62 9.90 30 89800 2918 50512376
Platelet aggregation inhibition 27.48 9.90 10 89820 126 50515168
Tissue infiltration 26.88 9.90 15 89815 538 50514756
Bursitis infective 26.42 9.90 20 89810 1214 50514080
Sedation 26.33 9.90 116 89714 30494 50484800
Foetal exposure during pregnancy 26.15 9.90 8 89822 27351 50487943
Pregnancy 25.93 9.90 10 89820 29567 50485727
Hepatocellular injury 25.88 9.90 7 89823 25940 50489354
Blood pressure systolic increased 25.84 9.90 128 89702 35321 50479973
Orthostatic hypotension 25.79 9.90 10 89820 29471 50485823
Basal ganglion degeneration 25.26 9.90 13 89817 395 50514899
Post procedural complication 24.97 9.90 71 89759 15033 50500261
Procedural pain 24.82 9.90 67 89763 13765 50501529
Respiratory syncytial virus infection 24.14 9.90 37 89793 5065 50510229
Monoplegia 23.80 9.90 27 89803 2756 50512538
Lactic acidosis 23.63 9.90 15 89815 33340 50481954
Intentional self-injury 23.50 9.90 6 89824 23106 50492188
Cardiac failure 23.25 9.90 64 89766 75976 50439318
Bronchomalacia 22.73 9.90 10 89820 212 50515082
Red cell distribution width increased 22.42 9.90 48 89782 8511 50506783
Screaming 22.32 9.90 27 89803 2951 50512343
Bradycardia 22.20 9.90 51 89779 64375 50450919
Acute kidney injury 21.69 9.90 280 89550 227778 50287516
Vaginal flatulence 21.52 9.90 10 89820 242 50515052
Localised infection 21.48 9.90 96 89734 25389 50489905
Amputation stump pain 21.15 9.90 6 89824 31 50515263
Malignant polyp 21.08 9.90 9 89821 177 50515117
Ligament pain 20.89 9.90 9 89821 181 50515113
Foot deformity 20.65 9.90 78 89752 19132 50496162
Spinal cord compression 20.58 9.90 29 89801 3680 50511614
Virologic failure 20.32 9.90 19 89811 1545 50513749
Extradural haematoma 20.08 9.90 19 89811 1568 50513726
Rheumatic fever 20.04 9.90 3 89827 16864 50498430
Cholestasis 20.04 9.90 10 89820 25391 50489903
Taste disorder 19.90 9.90 45 89785 8279 50507015
Knee arthroplasty 19.36 9.90 21 89809 35825 50479469
Apnoea 19.33 9.90 40 89790 6926 50508368
Drug eruption 19.07 9.90 9 89821 23597 50491697
Photophobia 19.04 9.90 64 89766 14823 50500471
Balance disorder 19.01 9.90 63 89767 70527 50444767
Rash pruritic 18.92 9.90 35 89795 47811 50467483
Pancreatitis 18.86 9.90 135 89695 42479 50472815
Foreign body embolism 18.58 9.90 4 89826 4 50515290
Hip arthroplasty 18.56 9.90 16 89814 30413 50484881
Infusion site mass 18.49 9.90 16 89814 1176 50514118
Blood immunoglobulin M decreased 18.39 9.90 13 89817 710 50514584
Accidental overdose 18.33 9.90 76 89754 19457 50495837
Dry eye 18.24 9.90 18 89812 32077 50483217
Premature baby 18.19 9.90 5 89825 18332 50496962
Anaesthesia 18.14 9.90 10 89820 350 50514944
Tumour pain 18.05 9.90 16 89814 1214 50514080
Limb mass 18.04 9.90 23 89807 2652 50512642
Drug tolerance 18.03 9.90 32 89798 4944 50510350
Uterine enlargement 17.95 9.90 15 89815 1051 50514243
Hypocalcaemia 17.74 9.90 13 89817 26803 50488491
Ocular procedural complication 17.64 9.90 10 89820 370 50514924
Impaired healing 17.63 9.90 64 89766 69722 50445572
Antidepressant drug level above therapeutic 17.57 9.90 10 89820 373 50514921
Poor venous access 17.48 9.90 49 89781 10291 50505003
Upper respiratory tract infection 17.27 9.90 186 89644 65712 50449582
Drug ineffective 17.24 9.90 1682 88148 817651 49697643
Substance dependence 17.12 9.90 8 89822 196 50515098
Red blood cell sedimentation rate abnormal 17.09 9.90 4 89826 16339 50498955
Intestinal obstruction 16.96 9.90 92 89738 26291 50489003
Swollen joint count increased 16.88 9.90 3 89827 14870 50500424
Eye disorder 16.87 9.90 72 89758 18667 50496627
Metastases to bone 16.87 9.90 70 89760 17925 50497369
Eye operation 16.86 9.90 19 89811 1925 50513369
Wrong technique in product usage process 16.76 9.90 47 89783 55463 50459831
Blood pressure fluctuation 16.74 9.90 115 89715 35708 50479586
No adverse event 16.71 9.90 21 89809 33557 50481737
Vitamin K deficiency 16.64 9.90 10 89820 413 50514881
Syncope 16.47 9.90 111 89719 102891 50412403
Biliary tract infection 16.28 9.90 10 89820 430 50514864
Cholangitis sclerosing 16.10 9.90 15 89815 1214 50514080
Caesarean section 16.02 9.90 4 89826 15635 50499659
Neuralgia 15.97 9.90 79 89751 21784 50493510
Dental caries 15.94 9.90 46 89784 9821 50505473
Cytomegalovirus infection 15.87 9.90 6 89824 17956 50497338
Radiation necrosis 15.85 9.90 9 89821 334 50514960
Emotional distress 15.84 9.90 96 89734 28567 50486727
Cystitis 15.75 9.90 134 89696 44430 50470864
Respiratory failure 15.65 9.90 238 89592 90943 50424351
Gait inability 15.64 9.90 116 89714 36911 50478383
Respiratory arrest 15.64 9.90 99 89731 29910 50485384
Dyspnoea 15.61 9.90 804 89026 546804 49968490
Substance abuse 15.56 9.90 27 89803 4097 50511197
Carbohydrate antigen 19-9 increased 15.43 9.90 7 89823 160 50515134
Toxicologic test abnormal 15.38 9.90 11 89819 612 50514682
Live birth 15.32 9.90 5 89825 16403 50498891
COVID-19 15.23 9.90 38 89792 46624 50468670
Accidental death 15.05 9.90 17 89813 1727 50513567
Groin pain 14.89 9.90 42 89788 8849 50506445
Psoriatic arthropathy 14.81 9.90 39 89791 46993 50468301
Multiple sclerosis relapse 14.81 9.90 34 89796 42930 50472364
Foreign body reaction 14.78 9.90 5 89825 50 50515244
Incorrect route of product administration 14.76 9.90 69 89761 18597 50496697
Adiposis dolorosa 14.75 9.90 8 89822 271 50515023
Erythema 14.72 9.90 352 89478 146062 50369232
Status epilepticus 14.59 9.90 3 89827 13403 50501891
Liver function test abnormal 14.46 9.90 131 89699 44208 50471086
Pulmonary embolism 14.33 9.90 257 89573 101447 50413847
Alanine aminotransferase increased 14.24 9.90 95 89735 88264 50427030
Iodine allergy 14.22 9.90 11 89819 690 50514604
Inappropriate antidiuretic hormone secretion 14.18 9.90 3 89827 13140 50502154
Atelectasis 14.05 9.90 67 89763 18203 50497091
Toe amputation 14.04 9.90 17 89813 1860 50513434
White blood cell count decreased 13.97 9.90 136 89694 116586 50398708
Silicon granuloma 13.93 9.90 3 89827 3 50515291
Cough 13.93 9.90 324 89506 240940 50274354
Laryngitis 13.93 9.90 47 89783 10909 50504385
Urticaria 13.86 9.90 155 89675 129406 50385888
Wound 13.63 9.90 121 89709 105673 50409621
Rheumatoid nodule 13.55 9.90 3 89827 12732 50502562
Cerebrospinal fluid leakage 13.43 9.90 12 89818 920 50514374
Suicide attempt 13.36 9.90 47 89783 51685 50463609
Osteoarthritis 13.33 9.90 183 89647 68423 50446871
Ill-defined disorder 13.23 9.90 51 89779 54603 50460691
Opiates positive 13.21 9.90 8 89822 335 50514959
Postoperative ileus 13.17 9.90 9 89821 465 50514829
Eye irritation 13.14 9.90 7 89823 17133 50498161
Rheumatoid factor positive 13.08 9.90 45 89785 49814 50465480
Visual acuity reduced 13.01 9.90 10 89820 20129 50495165
Death 13.01 9.90 704 89126 324675 50190619
Implant site haematoma 13.01 9.90 5 89825 74 50515220
Device infusion issue 12.96 9.90 14 89816 1353 50513941
Eastern Cooperative Oncology Group performance status worsened 12.91 9.90 10 89820 628 50514666
Mucosal inflammation 12.86 9.90 33 89797 40109 50475185
Toxic leukoencephalopathy 12.85 9.90 10 89820 633 50514661
Angioedema 12.84 9.90 30 89800 37646 50477648
Electrocardiogram QT prolonged 12.83 9.90 48 89782 51838 50463456
Ileus 12.83 9.90 52 89778 13177 50502117
Pneumocystis jirovecii pneumonia 12.78 9.90 5 89825 14658 50500636
Sopor 12.68 9.90 10 89820 19869 50495425
Discomfort 12.67 9.90 127 89703 108253 50407041
Aptyalism 12.66 9.90 9 89821 496 50514798
Drug intolerance 12.65 9.90 492 89338 218612 50296682
Weight decreased 12.58 9.90 496 89334 220749 50294545
Perineal pain 12.57 9.90 7 89823 250 50515044
Intestinal perforation 12.49 9.90 44 89786 10435 50504859
Psychiatric symptom 12.40 9.90 26 89804 4544 50510750
Tachyphylaxis 12.40 9.90 7 89823 257 50515037
Eosinophilia 12.39 9.90 9 89821 18643 50496651
Apnoeic attack 12.37 9.90 7 89823 258 50515036
Mental disorder 12.37 9.90 74 89756 21917 50493377
Infection 12.37 9.90 398 89432 172556 50342738
Skin laceration 12.31 9.90 66 89764 18776 50496518
Mucous stools 12.28 9.90 20 89810 2882 50512412
Device failure 12.24 9.90 29 89801 5499 50509795
Therapeutic product effect decreased 12.20 9.90 169 89661 135881 50379413
Pruritus 12.19 9.90 397 89433 283171 50232123
Mitral valve incompetence 12.18 9.90 8 89822 17463 50497831
Swollen tongue 12.18 9.90 20 89810 28610 50486684
Multiple organ dysfunction syndrome 12.17 9.90 47 89783 50290 50465004
Melaena 12.16 9.90 18 89812 26846 50488448
Respiratory tract inflammation 12.12 9.90 9 89821 531 50514763
Implant site pain 12.10 9.90 17 89813 2152 50513142
Klebsiella infection 12.07 9.90 34 89796 7160 50508134
Defaecation disorder 12.04 9.90 9 89821 536 50514758
Inguinal hernia 12.03 9.90 15 89815 1691 50513603
Bone marrow failure 12.03 9.90 19 89811 27605 50487689
Ocular hyperaemia 11.98 9.90 11 89819 20281 50495013
Injection site bruising 11.96 9.90 30 89800 36738 50478556
Abdominal tenderness 11.82 9.90 34 89796 7246 50508048
Anaesthetic complication neurological 11.79 9.90 6 89824 178 50515116
Palpitations 11.78 9.90 109 89721 94397 50420897
Withdrawal syndrome 11.76 9.90 62 89768 17528 50497766
Implant site infection 11.74 9.90 11 89819 897 50514397
Injection site warmth 11.65 9.90 5 89825 13861 50501433
Hypertension 11.54 9.90 286 89544 210917 50304377
Ischaemic stroke 11.53 9.90 7 89823 15941 50499353
Heart rate increased 11.52 9.90 197 89633 77053 50438241
Intestinal pseudo-obstruction 11.45 9.90 10 89820 744 50514550
Lupus-like syndrome 11.44 9.90 40 89790 9451 50505843
Pulmonary fibrosis 11.43 9.90 16 89814 24421 50490873
Inappropriate schedule of product administration 11.38 9.90 185 89645 71646 50443648
Blood triglycerides increased 11.38 9.90 3 89827 11309 50503985
Cholangitis infective 11.35 9.90 6 89824 193 50515101
Psychogenic seizure 11.28 9.90 14 89816 1571 50513723
Miliaria 11.28 9.90 11 89819 943 50514351
Seasonal allergy 11.24 9.90 6 89824 14670 50500624
Umbilical discharge 11.24 9.90 5 89825 109 50515185
Gastrointestinal haemorrhage 11.23 9.90 80 89750 73241 50442053
Irregular breathing 11.23 9.90 7 89823 309 50514985
Device computer issue 11.20 9.90 3 89827 12 50515282
Bacteraemia 11.15 9.90 53 89777 14380 50500914
Leukopenia 11.10 9.90 175 89655 67353 50447941
Monoclonal gammopathy 11.10 9.90 9 89821 604 50514690
Treatment noncompliance 11.10 9.90 23 89807 30127 50485167
Soft tissue swelling 11.07 9.90 11 89819 965 50514329
Intestinal metastasis 11.03 9.90 5 89825 114 50515180
Hypoxia 11.03 9.90 139 89691 50984 50464310
Rib fracture 11.02 9.90 65 89765 19156 50496138
Ejection fraction decreased 10.98 9.90 10 89820 18510 50496784
Intestinal resection 10.96 9.90 17 89813 2350 50512944
Drug ineffective for unapproved indication 10.96 9.90 70 89760 21211 50494083
Product storage error 10.94 9.90 4 89826 12220 50503074
Hyperkalaemia 10.93 9.90 46 89784 48043 50467251
Encephalitis brain stem 10.87 9.90 5 89825 118 50515176
Nerve block 10.80 9.90 8 89822 470 50514824
Chronic gastrointestinal bleeding 10.80 9.90 5 89825 120 50515174
Transient ischaemic attack 10.69 9.90 26 89804 32184 50483110
Coccygectomy 10.66 9.90 3 89827 15 50515279
Abdominal hernia 10.65 9.90 24 89806 4405 50510889
Joint stiffness 10.64 9.90 91 89739 30217 50485077
Hypothermia 10.64 9.90 4 89826 12012 50503282
Failure to thrive 10.62 9.90 30 89800 6328 50508966
Speech disorder 10.58 9.90 103 89727 35445 50479849
Device power source issue 10.52 9.90 8 89822 489 50514805
General physical health deterioration 10.50 9.90 329 89501 142105 50373189
Pseudostroke 10.50 9.90 3 89827 16 50515278
Diaphragmatic hernia 10.47 9.90 7 89823 349 50514945
Hypersplenism 10.46 9.90 6 89824 227 50515067
Dyspnoea exertional 10.45 9.90 51 89779 51182 50464112
Intervertebral disc protrusion 10.45 9.90 67 89763 20326 50494968
Respiratory rate increased 10.45 9.90 44 89786 11341 50503953
Toxicity to various agents 10.41 9.90 469 89361 212030 50303264
Product substitution issue 10.40 9.90 6 89824 14051 50501243
Wound infection bacterial 10.39 9.90 8 89822 498 50514796
Blood glucose increased 10.36 9.90 79 89751 71245 50444049
Diarrhoea 10.33 9.90 902 88928 587574 49927720
Extrapyramidal disorder 10.28 9.90 4 89826 11766 50503528
Cerebral infarction 10.25 9.90 14 89816 21590 50493704
Basal cell carcinoma 10.23 9.90 16 89814 23340 50491954
Product name confusion 10.18 9.90 4 89826 63 50515231
Blood albumin increased 10.18 9.90 10 89820 865 50514429
Heart rate irregular 10.17 9.90 64 89766 19296 50495998
Allodynia 10.15 9.90 9 89821 683 50514611
Spinal pain 10.11 9.90 42 89788 10761 50504533
Bone pain 10.01 9.90 128 89702 47101 50468193
Pancreatolithiasis 10.00 9.90 6 89824 247 50515047
Hypopnoea 9.97 9.90 16 89814 2277 50513017
Hypercapnia 9.95 9.90 24 89806 4603 50510691
Renal cyst 9.95 9.90 36 89794 8651 50506643
Functional residual capacity decreased 9.90 9.90 4 89826 68 50515226

FDA Adverse Event Reporting System (Male)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug dependence 237.05 10.86 226 47555 20755 29505991
Appendicolith 138.10 10.86 80 47701 3400 29523346
Drug withdrawal syndrome 137.09 10.86 157 47624 17827 29508919
Pain 131.13 10.86 586 47195 170846 29355900
Nausea 111.43 10.86 823 46958 288432 29238314
Hyperaesthesia 104.88 10.86 67 47714 3402 29523344
Sedation 103.46 10.86 134 47647 17271 29509475
Constipation 93.04 10.86 398 47383 113762 29412984
Appendicitis 86.86 10.86 88 47693 8691 29518055
Stress 81.80 10.86 134 47647 21356 29505390
Respiratory depression 72.50 10.86 99 47682 13424 29513322
Vomiting 69.91 10.86 583 47198 211677 29315069
Drug tolerance 68.62 10.86 43 47738 2110 29524636
Victim of child abuse 64.07 10.86 30 47751 815 29525931
Toxicologic test abnormal 63.47 10.86 26 47755 507 29526239
Abdominal pain 61.79 10.86 402 47379 134955 29391791
Postmortem blood drug level abnormal 58.98 10.86 21 47760 274 29526472
Inadequate analgesia 53.63 10.86 40 47741 2614 29524132
Back pain 51.77 10.86 312 47469 101972 29424774
Abdominal distension 49.50 10.86 175 47606 45736 29481010
Medical device site pain 48.08 10.86 13 47768 61 29526685
Drug interaction 46.09 10.86 164 47617 197221 29329525
Cardiogenic shock 45.84 10.86 98 47683 19092 29507654
Chest injury 44.12 10.86 28 47753 1405 29525341
Serotonin syndrome 41.33 10.86 89 47692 17423 29509323
Myoclonus 40.23 10.86 75 47706 13234 29513512
Drug abuse 39.96 10.86 243 47538 79640 29447106
Painful respiration 38.81 10.86 24 47757 1150 29525596
Respiratory rate decreased 38.60 10.86 29 47752 1916 29524830
Arachnoiditis 38.27 10.86 16 47765 329 29526417
Drug hypersensitivity 38.04 10.86 214 47567 68192 29458554
Cardiac failure 37.15 10.86 44 47737 79243 29447503
Product prescribing error 36.44 10.86 86 47695 17890 29508856
Walking aid user 36.12 10.86 25 47756 1452 29525294
Device power source issue 35.86 10.86 15 47766 309 29526437
Ascites 34.77 10.86 134 47647 36485 29490261
Plasma cell myeloma 34.58 10.86 135 47646 36980 29489766
Postoperative ileus 34.46 10.86 18 47763 622 29526124
Interstitial lung disease 34.09 10.86 26 47755 57692 29469054
Prostate cancer metastatic 33.92 10.86 41 47740 4925 29521821
Substance abuse 33.85 10.86 48 47733 6739 29520007
Unresponsive to stimuli 33.54 10.86 103 47678 25023 29501723
Mental status changes 32.51 10.86 127 47654 34800 29491946
Epidural lipomatosis 29.96 10.86 17 47764 694 29526052
Xyphoid retraction 29.68 10.86 11 47770 162 29526584
Acute kidney injury 29.62 10.86 280 47501 264987 29261759
Hyperhidrosis 28.96 10.86 191 47590 64349 29462397
Myocardial infarction 28.91 10.86 87 47694 110209 29416537
Delirium 28.71 10.86 133 47648 39264 29487482
Drug tolerance increased 27.76 10.86 14 47767 449 29526297
Product dose omission issue 27.49 10.86 73 47708 96310 29430436
Seizure like phenomena 26.47 10.86 15 47766 611 29526135
General physical health deterioration 26.37 10.86 268 47513 102589 29424157
Systemic infection 26.34 10.86 24 47757 2077 29524669
Opiates positive 26.18 10.86 14 47767 508 29526238
Anaesthetic complication neurological 26.08 10.86 12 47769 313 29526433
Confusional state 25.87 10.86 318 47463 127559 29399187
Cardiac failure congestive 25.01 10.86 54 47727 76527 29450219
Respiratory arrest 24.90 10.86 95 47686 25738 29501008
Substance dependence 24.84 10.86 12 47769 350 29526396
Immune-mediated hepatitis 24.33 10.86 20 47761 1507 29525239
Malignant neoplasm progression 24.26 10.86 203 47578 73656 29453090
Hepatic function abnormal 24.07 10.86 17 47764 39242 29487504
Withdrawal syndrome 23.83 10.86 54 47727 10938 29515808
Child abuse 23.26 10.86 10 47771 221 29526525
Overdose 22.92 10.86 213 47568 79606 29447140
Hyponatraemia 22.81 10.86 187 47594 67446 29459300
Renal failure 22.34 10.86 107 47674 118492 29408254
Oesophageal infection 21.48 10.86 10 47771 268 29526478
Cerebral haemorrhage 21.48 10.86 12 47769 31414 29495332
Rhabdomyolysis 21.45 10.86 41 47740 60767 29465979
Lymphoedema 21.38 10.86 27 47754 3390 29523356
Congenital megaureter 21.04 10.86 8 47773 127 29526619
Pelvic pain 20.85 10.86 21 47760 2058 29524688
Blood creatine phosphokinase increased 20.75 10.86 21 47760 40623 29486123
Death 20.54 10.86 709 47072 341375 29185371
Apnoeic attack 20.38 10.86 10 47771 302 29526444
Sickle cell anaemia with crisis 20.25 10.86 23 47758 2585 29524161
Drug reaction with eosinophilia and systemic symptoms 20.15 10.86 10 47771 27982 29498764
Juvenile idiopathic arthritis 19.62 10.86 17 47764 1377 29525369
Hallucination 19.25 10.86 131 47650 44581 29482165
Forced expiratory flow decreased 19.25 10.86 8 47773 162 29526584
Electrocardiogram QT prolonged 19.22 10.86 18 47763 36119 29490627
Eosinophilia 19.10 10.86 6 47775 22155 29504591
Device kink 18.85 10.86 10 47771 357 29526389
Neutropenia 18.80 10.86 130 47651 131581 29395165
Syncope 18.68 10.86 68 47713 81303 29445443
Poor venous access 18.25 10.86 24 47757 3137 29523609
Haemorrhoids thrombosed 18.19 10.86 8 47773 187 29526559
Hypersomnia 18.16 10.86 48 47733 10706 29516040
Microembolism 18.07 10.86 5 47776 26 29526720
Foreign body embolism 18.06 10.86 4 47777 6 29526740
Muscle spasticity 17.97 10.86 30 47751 4853 29521893
Lethargy 17.94 10.86 113 47668 37467 29489279
Pancreatic carcinoma metastatic 17.83 10.86 22 47759 2699 29524047
Delirium tremens 17.83 10.86 11 47770 525 29526221
Neuralgia 17.82 10.86 48 47733 10826 29515920
Needle issue 17.54 10.86 29 47752 4654 29522092
Oesophageal mucosa erythema 17.47 10.86 5 47776 30 29526716
Sputum discoloured 17.41 10.86 35 47746 6528 29520218
Renal impairment 17.36 10.86 70 47711 81263 29445483
Coronary artery disease 17.21 10.86 28 47753 44162 29482584
Blood pressure systolic increased 17.11 10.86 63 47718 16782 29509964
Axillary pain 17.10 10.86 9 47772 316 29526430
Hypoxia 17.06 10.86 133 47648 47246 29479500
Bradycardia 17.01 10.86 52 47729 65577 29461169
Mucosal atrophy 17.01 10.86 6 47775 76 29526670
Spinal shock 16.93 10.86 5 47776 34 29526712
Intentional product use issue 16.82 10.86 122 47659 42376 29484370
Urinary tract disorder 16.66 10.86 18 47763 1914 29524832
Hot flush 16.28 10.86 57 47724 14813 29511933
Antasthmatic drug level 16.23 10.86 5 47776 40 29526706
Analgesic drug level 16.23 10.86 5 47776 40 29526706
Hepatocellular injury 16.20 10.86 7 47774 21236 29505510
Lactic acidosis 16.16 10.86 15 47766 30232 29496514
Infusion site mass 16.02 10.86 8 47773 251 29526495
Suicide attempt 15.89 10.86 19 47762 34091 29492655
Burkholderia test positive 15.74 10.86 13 47768 986 29525760
Angioedema 15.71 10.86 17 47764 31898 29494848
Cytomegalovirus infection 15.67 10.86 9 47772 23206 29503540
Nightmare 15.41 10.86 47 47734 11370 29515376
Bone marrow failure 15.41 10.86 13 47768 27436 29499310
Carditis 15.29 10.86 6 47775 104 29526642
Hip surgery 15.29 10.86 12 47769 846 29525900
Neoplasm progression 15.19 10.86 65 47716 18547 29508199
Neurotoxicity 15.13 10.86 55 47726 14558 29512188
Terminal insomnia 15.11 10.86 9 47772 403 29526343
Paranasal sinus discomfort 15.04 10.86 11 47770 697 29526049
Brief psychotic disorder with marked stressors 14.95 10.86 7 47774 190 29526556
Device computer issue 14.93 10.86 4 47777 18 29526728
Melaena 14.92 10.86 17 47764 31159 29495587
Device failure 14.35 10.86 17 47764 1999 29524747
Hypoglycaemia 14.24 10.86 36 47745 48310 29478436
Epilepsy 14.17 10.86 6 47775 18426 29508320
Blood pressure diastolic abnormal 14.16 10.86 19 47762 2532 29524214
Device infusion issue 14.13 10.86 10 47771 602 29526144
Cerebrovascular accident 14.12 10.86 70 47711 76841 29449905
Peripheral swelling 13.96 10.86 161 47620 63578 29463168
Postmortem blood drug level increased 13.89 10.86 7 47774 224 29526522
Gastrointestinal tract irritation 13.87 10.86 7 47774 225 29526521
Somnolence 13.86 10.86 221 47560 93734 29433012
Dyspnoea paroxysmal nocturnal 13.83 10.86 14 47767 1380 29525366
Odynophagia 13.72 10.86 26 47755 4644 29522102
Failure to thrive 13.70 10.86 35 47746 7649 29519097
Postmortem blood drug level 13.61 10.86 6 47775 141 29526605
Bone infarction 13.48 10.86 7 47774 239 29526507
Facial wasting 13.46 10.86 6 47775 145 29526601
Oxygen saturation decreased 13.43 10.86 121 47660 44816 29481930
Injection site mass 13.18 10.86 28 47753 5427 29521319
Gastrointestinal haemorrhage 13.15 10.86 75 47706 79458 29447288
Withdrawal hypertension 13.02 10.86 6 47775 157 29526589
Administration related reaction 13.00 10.86 5 47776 82 29526664
Osteomyelitis 12.87 10.86 50 47731 13659 29513087
Anaemia of malignant disease 12.85 10.86 8 47773 388 29526358
Intentional overdose 12.71 10.86 27 47754 38501 29488245
Body temperature decreased 12.66 10.86 42 47739 10622 29516124
Post-thoracotomy pain syndrome 12.57 10.86 4 47777 36 29526710
Rib fracture 12.44 10.86 47 47734 12671 29514075
Mucous stools 12.36 10.86 12 47769 1125 29525621
Cerebral infarction 12.31 10.86 13 47768 24662 29502084
Basal cell carcinoma 12.23 10.86 6 47775 16904 29509842
Harlequin syndrome 12.15 10.86 3 47778 9 29526737
Erythema 12.12 10.86 72 47709 75534 29451212
Peripheral artery thrombosis 12.08 10.86 16 47765 2106 29524640
Nephrolithiasis 11.98 10.86 76 47705 25258 29501488
Ankylosing spondylitis 11.96 10.86 23 47758 4153 29522593
Allodynia 11.85 10.86 9 47772 604 29526142
Blood pressure systolic abnormal 11.85 10.86 16 47765 2145 29524601
Aortic aneurysm 11.79 10.86 29 47752 6191 29520555
Thymic cancer metastatic 11.69 10.86 4 47777 46 29526700
Pseudopolyp 11.50 10.86 6 47775 207 29526539
Palpitations 11.48 10.86 22 47759 32582 29494164
Hepatitis 11.47 10.86 10 47771 20773 29505973
Gastrointestinal scarring 11.37 10.86 5 47776 117 29526629
Chylothorax 11.35 10.86 9 47772 644 29526102
Drug use disorder 11.25 10.86 20 47761 3402 29523344
Umbilical hernia 11.23 10.86 21 47760 3714 29523032
Heart rate increased 11.21 10.86 104 47677 38834 29487912
Toxicity to various agents 11.14 10.86 363 47418 173298 29353448
Arrhythmia 11.14 10.86 21 47760 31292 29495454
Blood albumin abnormal 11.09 10.86 6 47775 223 29526523
Blood pressure increased 11.03 10.86 174 47607 73629 29453117
Labelled drug-drug interaction medication error 11.01 10.86 3 47778 12156 29514590
Diffuse large B-cell lymphoma recurrent 10.98 10.86 17 47764 2580 29524166
Parkinsonian rest tremor 10.95 10.86 5 47776 128 29526618
Type IIa hyperlipidaemia 10.88 10.86 5 47776 130 29526616

FDA Adverse Event Reporting System (Geriatric)

MedDRA adverse event termLikelihood ratioLikelihood ratio thresholdPatients taking drug having adverse eventPatients taking drug not having adverse eventPatients not taking drug having adverse eventPatients not taking drug not having adverse event
Drug hypersensitivity 342.08 9.99 1057 112543 236758 64148374
Temperature regulation disorder 258.41 9.99 133 113467 4078 64381054
Drug withdrawal syndrome 241.93 9.99 287 113313 31004 64354128
Constipation 205.50 9.99 874 112726 228463 64156669
Drug dependence 199.49 9.99 269 113331 33043 64352089
Food allergy 193.38 9.99 138 113462 7713 64377419
Coeliac disease 188.84 9.99 133 113467 7279 64377853
Hyperaesthesia 178.18 9.99 145 113455 9869 64375263
Nausea 167.01 9.99 2112 111488 783688 63601444
Pain 165.84 9.99 1593 112007 551918 63833214
Immunodeficiency 138.22 9.99 156 113444 15968 64369164
Appendicolith 131.90 9.99 80 113520 3389 64381743
Bursitis 124.83 9.99 171 113429 21314 64363818
Drug interaction 122.12 9.99 287 113313 361796 64023336
Rheumatoid arthritis 120.81 9.99 591 113009 163703 64221429
Back pain 118.33 9.99 800 112800 249371 64135761
Respiratory depression 117.66 9.99 174 113426 23269 64361863
Vomiting 107.72 9.99 1460 112140 549657 63835475
Somnolence 100.95 9.99 659 112941 202986 64182146
Sedation 89.20 9.99 214 113386 41248 64343884
Medical device site pain 87.63 9.99 28 113572 232 64384900
Pneumonia viral 87.14 9.99 87 113513 7735 64377397
Delirium 81.67 9.99 288 113312 68906 64316226
Ankylosing spondylitis 78.07 9.99 84 113516 8150 64376982
Unresponsive to stimuli 77.85 9.99 230 113370 50163 64334969
Respiratory rate decreased 77.73 9.99 64 113536 4427 64380705
Hyperhidrosis 71.74 9.99 420 113180 124500 64260632
Toxicologic test abnormal 70.32 9.99 37 113563 1188 64383944
Abdominal pain 68.58 9.99 846 112754 311529 64073603
Interstitial lung disease 68.19 9.99 44 113556 97688 64287444
Soft tissue disorder 68.11 9.99 52 113548 3224 64381908
Myocardial infarction 65.45 9.99 120 113480 165701 64219431
Inadequate analgesia 65.35 9.99 55 113545 3923 64381209
Pneumonia aspiration 64.27 9.99 240 113360 59031 64326101
Arthritis 61.18 9.99 301 113299 83513 64301619
Victim of child abuse 60.74 9.99 30 113570 841 64384291
Extremity contracture 60.56 9.99 37 113563 1588 64383544
Joint dislocation 60.28 9.99 87 113513 11378 64373754
Acute kidney injury 58.94 9.99 507 113093 448733 63936399
Drug tolerance 57.56 9.99 62 113538 6023 64379109
Exostosis 57.54 9.99 85 113515 11353 64373779
Neutropenia 56.96 9.99 223 113377 239401 64145731
Malignant neoplasm progression 55.70 9.99 365 113235 112506 64272626
Neoplasm progression 54.94 9.99 178 113422 40786 64344346
Drug reaction with eosinophilia and systemic symptoms 54.64 9.99 14 113586 54203 64330929
Appendicitis 54.59 9.99 91 113509 13478 64371654
Intentional overdose 54.36 9.99 47 113553 89897 64295235
Cardiac failure congestive 53.78 9.99 92 113508 130488 64254644
Hypermobility syndrome 52.06 9.99 23 113577 497 64384635
Sickle cell anaemia with crisis 51.62 9.99 55 113545 5277 64379855
Cardiac failure 51.16 9.99 97 113503 132276 64252856
Postmortem blood drug level abnormal 50.28 9.99 24 113576 623 64384509
Hepatic function abnormal 47.59 9.99 27 113573 64286 64320846
Lower respiratory tract infection 47.48 9.99 58 113542 94556 64290576
Mental status changes 47.04 9.99 223 113377 60939 64324193
Postoperative ileus 46.22 9.99 26 113574 955 64384177
Duodenal ulcer perforation 46.10 9.99 4 113596 34621 64350511
Gastrooesophageal reflux disease 46.08 9.99 277 113323 82866 64302266
Orthostatic hypotension 45.35 9.99 13 113587 46725 64338407
Narcotic bowel syndrome 45.29 9.99 17 113583 237 64384895
Drug diversion 45.27 9.99 27 113573 1109 64384023
Renal impairment 44.63 9.99 108 113492 134909 64250223
Breast cancer metastatic 44.60 9.99 59 113541 7110 64378022
Stress 44.60 9.99 218 113382 60316 64324816
Drug abuse 44.42 9.99 391 113209 131983 64253149
Lactic acidosis 43.72 9.99 27 113573 61383 64323749
Helicobacter infection 42.51 9.99 8 113592 38354 64346778
General physical health deterioration 41.96 9.99 547 113053 203878 64181254
Hepatocellular injury 41.35 9.99 14 113586 45221 64339911
Postmortem blood drug level increased 40.90 9.99 22 113578 739 64384393
Small intestinal obstruction 40.69 9.99 112 113488 23461 64361671
Alopecia 40.12 9.99 153 113447 165537 64219595
Blood pressure systolic increased 40.01 9.99 183 113417 49270 64335862
Bradycardia 39.52 9.99 94 113506 118125 64267007
Injection site erythema 39.25 9.99 40 113560 70760 64314372
Retinitis 38.80 9.99 31 113569 2054 64383078
Implant site extravasation 38.52 9.99 21 113579 725 64384407
Plasma cell myeloma 38.39 9.99 172 113428 45903 64339229
Opiates positive 37.50 9.99 22 113578 876 64384256
Drug resistance 37.48 9.99 8 113592 35094 64350038
Hepatitis 36.91 9.99 17 113583 45565 64339567
Poor venous access 36.87 9.99 73 113527 12344 64372788
Scar 36.50 9.99 76 113524 13322 64371810
Foreign body embolism 36.28 9.99 8 113592 10 64385122
Anaesthetic complication neurological 35.73 9.99 18 113582 527 64384605
Syncope 34.74 9.99 151 113449 157484 64227648
Product dose omission issue 34.67 9.99 201 113399 194546 64190586
Bone erosion 34.23 9.99 68 113532 11527 64373605
Injection site pruritus 34.07 9.99 12 113588 37814 64347318
Therapeutic product effect incomplete 33.85 9.99 304 113296 103178 64281954
Osteoporosis 33.51 9.99 155 113445 41925 64343207
Hepatic cirrhosis 33.23 9.99 112 113488 26186 64358946
Foot deformity 33.16 9.99 83 113517 16421 64368711
Cytomegalovirus infection 33.16 9.99 12 113588 37187 64347945
Eosinophilia 32.75 9.99 13 113587 38063 64347069
Device related thrombosis 32.55 9.99 28 113572 2057 64383075
Synovitis 31.85 9.99 290 113310 98800 64286332
Electrocardiogram QT prolonged 31.77 9.99 57 113543 79391 64305741
Coronary artery disease 31.44 9.99 36 113564 60397 64324735
Rhabdomyolysis 31.40 9.99 72 113528 91654 64293478
Injection site swelling 31.11 9.99 17 113583 41336 64343796
Device failure 31.11 9.99 44 113556 5648 64379484
Gastrointestinal haemorrhage 30.86 9.99 124 113476 132188 64252944
Overwork 30.82 9.99 9 113591 53 64385079
Chest injury 30.74 9.99 29 113571 2404 64382728
Drug tolerance increased 30.74 9.99 17 113583 604 64384528
Infusion site mass 30.71 9.99 20 113580 961 64384171
Asthma 30.26 9.99 278 113322 94947 64290185
Rash erythematous 30.18 9.99 167 113433 48466 64336666
Fluid retention 30.15 9.99 194 113406 59412 64325720
Pustular psoriasis 30.08 9.99 37 113563 4146 64380986
Neuralgia 30.04 9.99 108 113492 26076 64359056
Agranulocytosis 29.82 9.99 15 113585 38214 64346918
Acute chest syndrome 29.47 9.99 19 113581 897 64384235
Myoclonus 29.15 9.99 104 113496 25014 64360118
Arachnoiditis 29.09 9.99 17 113583 672 64384460
Bone marrow failure 29.04 9.99 25 113575 47927 64337205
Respiratory arrest 29.01 9.99 176 113424 52809 64332323
Angioedema 28.85 9.99 40 113560 61781 64323351
Xyphoid retraction 28.76 9.99 11 113589 162 64384970
Death 28.34 9.99 1078 112522 481627 63903505
Muscle injury 28.28 9.99 6 113594 26431 64358701
Overdose 28.27 9.99 416 113184 159150 64225982
Apnoea 28.25 9.99 59 113541 10363 64374769
Glossodynia 28.10 9.99 44 113556 64652 64320480
Red cell distribution width increased 28.06 9.99 65 113535 12244 64372888
Rash 28.04 9.99 605 112995 457944 63927188
Sleep disorder due to general medical condition, insomnia type 28.02 9.99 6 113594 26264 64358868
Oral pain 27.88 9.99 109 113491 27384 64357748
Rhesus antigen positive 27.70 9.99 10 113590 124 64385008
Cholestasis 27.66 9.99 23 113577 44849 64340283
Pemphigus 27.61 9.99 40 113560 60661 64324471
Suicide attempt 27.45 9.99 52 113548 70955 64314177
Hereditary angioedema 27.42 9.99 34 113566 3842 64381290
Procedural pain 27.08 9.99 74 113526 15434 64369698
Maternal exposure during pregnancy 26.95 9.99 83 113517 95801 64289331
Melaena 26.68 9.99 33 113567 53515 64331617
Platelet aggregation inhibition 26.54 9.99 10 113590 141 64384991
Abdominal distension 26.45 9.99 272 113328 95722 64289410
Treatment failure 26.29 9.99 111 113489 116705 64268427
Alanine aminotransferase increased 26.09 9.99 141 113459 138890 64246242
Herpes zoster 26.08 9.99 233 113367 78954 64306178
Cerebral haemorrhage 25.96 9.99 31 113569 51059 64334073
Substance dependence 25.87 9.99 14 113586 476 64384656
Epidural lipomatosis 25.32 9.99 17 113583 860 64384272
Acute myocardial infarction 25.28 9.99 53 113547 69665 64315467
Cerebrovascular accident 25.01 9.99 141 113459 137442 64247690
Hypertensive encephalopathy 24.92 9.99 17 113583 883 64384249
Systemic lupus erythematosus 24.92 9.99 63 113537 77549 64307583
Metastases to bone 24.91 9.99 86 113514 20349 64364783
Amputation stump pain 24.76 9.99 7 113593 36 64385096
Folliculitis 24.69 9.99 11 113589 30066 64355066
Blood pressure fluctuation 24.52 9.99 166 113434 51705 64333427
Device power source issue 24.40 9.99 16 113584 778 64384354
Blood pressure increased 24.27 9.99 433 113167 172119 64213013
Incorrect route of product administration 24.14 9.99 93 113507 23205 64361927
Extrapyramidal disorder 24.12 9.99 3 113597 19549 64365583
Alveolitis 23.92 9.99 31 113569 3661 64381471
Apnoeic attack 23.87 9.99 14 113586 557 64384575
Hypoaesthesia 23.60 9.99 360 113240 138748 64246384
Migraine 23.59 9.99 190 113410 62487 64322645
Blood immunoglobulin M decreased 23.55 9.99 17 113583 967 64384165
Prostate cancer metastatic 23.40 9.99 29 113571 3275 64381857
Heart rate increased 23.23 9.99 271 113329 98404 64286728
Systemic infection 23.02 9.99 33 113567 4288 64380844
Status epilepticus 23.00 9.99 5 113595 21658 64363474
Child abuse 22.90 9.99 10 113590 210 64384922
Blister 22.82 9.99 70 113530 80897 64304235
Exposure during pregnancy 22.72 9.99 66 113534 77609 64307523
Head banging 22.59 9.99 13 113587 499 64384633
Device infusion issue 22.30 9.99 21 113579 1737 64383395
Osteoarthritis 22.23 9.99 189 113411 63147 64321985
Anti-cyclic citrullinated peptide antibody positive 22.20 9.99 33 113567 49529 64335603
Hyperkalaemia 22.20 9.99 97 113503 101032 64284100
Hypoxia 22.06 9.99 245 113355 87904 64297228
Inappropriate antidiuretic hormone secretion 21.99 9.99 6 113594 22283 64362849
Rheumatoid factor negative 21.96 9.99 17 113583 1076 64384056
Neurotoxicity 21.86 9.99 101 113499 27303 64357829
Rib fracture 21.75 9.99 92 113508 23946 64361186
Drug eruption 21.69 9.99 19 113581 36117 64349015
Allodynia 21.61 9.99 18 113582 1265 64383867
Blepharospasm 21.34 9.99 28 113572 3347 64381785
Pneumocystis jirovecii pneumonia 21.32 9.99 11 113589 27623 64357509
Immune-mediated hepatitis 21.19 9.99 24 113576 2465 64382667
Fatigue 20.93 9.99 1559 112041 747171 63637961
Tissue infiltration 20.82 9.99 13 113587 580 64384552
Compartment syndrome 20.64 9.99 31 113569 4201 64380931
Serotonin syndrome 20.57 9.99 129 113471 39153 64345979
Photophobia 20.41 9.99 72 113528 17221 64367911
Ligament pain 20.39 9.99 9 113591 194 64384938
Transient ischaemic attack 20.20 9.99 29 113571 44153 64340979
Drug intolerance 20.17 9.99 453 113147 187539 64197593
Spinal cord compression 20.00 9.99 36 113564 5667 64379465
Coma 19.90 9.99 239 113361 87376 64297756
Hypoglycaemia 19.86 9.99 86 113514 89806 64295326
Progressive multifocal leukoencephalopathy 19.78 9.99 4 113596 18228 64366904
Basal ganglion degeneration 19.73 9.99 11 113589 397 64384735
Irritable bowel syndrome 19.72 9.99 22 113578 37347 64347785
Cerebral infarction 19.71 9.99 26 113574 41018 64344114
Ascites 19.68 9.99 181 113419 61820 64323312
Aspartate aminotransferase increased 19.55 9.99 127 113473 119661 64265471
Abortion spontaneous 19.41 9.99 10 113590 25133 64359999
Visual acuity reduced 19.22 9.99 12 113588 27129 64358003
Anaemia of malignant disease 19.16 9.99 13 113587 669 64384463
Myelosuppression 19.12 9.99 9 113591 23821 64361311
Radiation necrosis 18.98 9.99 10 113590 322 64384810
Forced expiratory flow decreased 18.95 9.99 9 113591 231 64384901
Painful respiration 18.62 9.99 25 113575 3056 64382076
Malignant polyp 18.58 9.99 8 113592 162 64384970
Rash maculo-papular 18.56 9.99 34 113566 46992 64338140
Pancreatitis 18.42 9.99 173 113427 59434 64325698
Eye operation 18.37 9.99 19 113581 1761 64383371
Pericarditis 18.37 9.99 53 113547 62463 64322669
Anxiety 18.32 9.99 477 113123 202172 64182960
Pregnancy 18.15 9.99 7 113593 20858 64364274
Rash pruritic 18.12 9.99 47 113553 57357 64327775
Renal failure 17.99 9.99 219 113381 181469 64203663
Substance abuse 17.91 9.99 46 113554 9246 64375886
Hand deformity 17.88 9.99 54 113546 62717 64322415
Intentional self-injury 17.76 9.99 15 113585 29029 64356103
Seizure like phenomena 17.71 9.99 18 113582 1634 64383498
Inappropriate schedule of product administration 17.69 9.99 244 113356 92042 64293090
Blood creatine phosphokinase increased 17.68 9.99 49 113551 58509 64326623
Basal cell carcinoma 17.57 9.99 17 113583 30821 64354311
Walking aid user 17.54 9.99 36 113564 6245 64378887
Limb mass 17.48 9.99 24 113576 2997 64382135
Screaming 17.42 9.99 26 113574 3503 64381629
Nervousness 17.35 9.99 100 113500 29456 64355676
Sopor 17.31 9.99 16 113584 29645 64355487
Fibromyalgia 17.28 9.99 115 113485 35616 64349516
Drug use disorder 17.27 9.99 35 113565 6019 64379113
Respiratory syncytial virus infection 17.25 9.99 39 113561 7229 64377903
Diabetes mellitus inadequate control 17.19 9.99 8 113592 21313 64363819
Umbilical hernia 17.00 9.99 29 113571 4376 64380756
International normalised ratio increased 16.73 9.99 77 113523 79090 64306042
Hypothermia 16.72 9.99 7 113593 19849 64365283
Cardiogenic shock 16.68 9.99 106 113494 32321 64352811
Spinal shock 16.64 9.99 5 113595 33 64385099
Liver disorder 16.59 9.99 44 113556 53307 64331825
Failure to thrive 16.55 9.99 48 113552 10356 64374776
Tubulointerstitial nephritis 16.52 9.99 18 113582 30891 64354241
Device computer issue 16.51 9.99 5 113595 34 64385098
Palpitations 16.43 9.99 112 113488 104376 64280756
Therapeutic response decreased 16.39 9.99 152 113448 52036 64333096
Accidental overdose 16.22 9.99 108 113492 33449 64351683
Ocular procedural complication 15.96 9.99 10 113590 449 64384683
Swollen tongue 15.93 9.99 23 113577 34931 64350201
Antasthmatic drug level 15.80 9.99 5 113595 40 64385092
Post procedural complication 15.79 9.99 77 113523 21276 64363856
Hyperthermia 15.70 9.99 4 113596 15546 64369586
Septic shock 15.62 9.99 115 113485 105322 64279810
Lethargy 15.61 9.99 196 113404 72398 64312734
Adverse drug reaction 15.60 9.99 135 113465 45329 64339803
Osteonecrosis of jaw 15.54 9.99 29 113571 39796 64345336
Thrombocytopenia 15.53 9.99 289 113311 223512 64161620
Tenderness 15.45 9.99 72 113528 19530 64365602
Ischaemic stroke 15.42 9.99 17 113583 29018 64356114
Body temperature decreased 15.40 9.99 88 113512 25840 64359292
Lupus-like syndrome 15.40 9.99 42 113558 8749 64376383
Analgesic drug level 15.38 9.99 5 113595 44 64385088
Uterine enlargement 15.37 9.99 12 113588 769 64384363
Injection site pain 15.33 9.99 124 113476 111284 64273848
Biliary tract infection 15.32 9.99 13 113587 938 64384194
Labelled drug-drug interaction medication error 15.29 9.99 10 113590 22052 64363080
Colorectal cancer metastatic 15.21 9.99 13 113587 947 64384185
Microembolism 15.19 9.99 5 113595 46 64385086
Urticaria 15.18 9.99 176 113424 147141 64237991
Monoplegia 15.08 9.99 24 113576 3419 64381713
Sinus bradycardia 15.04 9.99 11 113589 22882 64362250
Hypopnoea 15.02 9.99 23 113577 3171 64381961
Red blood cell sedimentation rate abnormal 14.98 9.99 5 113595 16301 64368831
Neck pain 14.93 9.99 170 113430 61363 64323769
Adiposis dolorosa 14.81 9.99 8 113592 271 64384861
Hepatotoxicity 14.81 9.99 30 113570 39932 64345200
Arthritis infective 14.81 9.99 36 113564 6994 64378138
Obstruction 14.73 9.99 23 113577 3225 64381907
Peripheral swelling 14.69 9.99 477 113123 208676 64176456
Eye disorder 14.65 9.99 69 113531 18800 64366332
Mitral valve incompetence 14.64 9.99 14 113586 25524 64359608
Vitamin K deficiency 14.61 9.99 11 113589 668 64384464
COVID-19 14.58 9.99 62 113538 65078 64320054
Exposure to toxic agent 14.56 9.99 33 113567 6126 64379006
Ileus 14.34 9.99 79 113521 22887 64362245
Tricuspid valve incompetence 14.30 9.99 6 113594 16997 64368135
Oesophageal infection 14.26 9.99 10 113590 543 64384589
Pelvic pain 14.26 9.99 47 113553 10863 64374269
Anaesthesia 14.25 9.99 9 113591 410 64384722
Miliaria 14.21 9.99 14 113586 1224 64383908
Intestinal obstruction 14.20 9.99 111 113489 36175 64348957
Psychomotor hyperactivity 14.05 9.99 4 113596 14447 64370685
Musculoskeletal pain 14.02 9.99 211 113389 81083 64304049
Silicon granuloma 13.96 9.99 3 113597 3 64385129
Odynophagia 13.94 9.99 43 113557 9598 64375534
Tuberculosis 13.86 9.99 3 113597 13035 64372097
Cough 13.78 9.99 416 113184 301732 64083400
Tumour pain 13.74 9.99 17 113583 1916 64383216
Heart rate irregular 13.72 9.99 89 113511 27324 64357808
Blood glucose increased 13.57 9.99 109 113491 97964 64287168
Cholangitis infective 13.50 9.99 9 113591 450 64384682
Delirium tremens 13.38 9.99 10 113590 600 64384532
Stevens-Johnson syndrome 13.31 9.99 25 113575 34224 64350908
Pulmonary fibrosis 13.28 9.99 20 113580 29858 64355274
Drug ineffective 13.26 9.99 1681 111919 838566 63546566
Lymphoedema 13.24 9.99 43 113557 9862 64375270
Blood loss anaemia 13.23 9.99 4 113596 13888 64371244
Pathogen resistance 13.10 9.99 3 113597 12540 64372592
Needle issue 13.08 9.99 41 113559 9231 64375901
Groin pain 13.07 9.99 47 113553 11346 64373786
Myocardial ischaemia 13.04 9.99 13 113587 23238 64361894
Sinusitis 12.93 9.99 180 113420 145748 64239384
Reading disorder 12.86 9.99 11 113589 802 64384330
Withdrawal syndrome 12.84 9.99 78 113522 23414 64361718
Product prescribing error 12.77 9.99 106 113494 35163 64349969
Abdominal tenderness 12.73 9.99 41 113559 9364 64375768
Blood pressure diastolic abnormal 12.70 9.99 48 113552 11869 64373263
Abdominal pain lower 12.68 9.99 85 113515 26384 64358748
Anuria 12.60 9.99 9 113591 18955 64366177
Implant site haematoma 12.56 9.99 6 113594 156 64384976
Blood urea increased 12.56 9.99 38 113562 44115 64341017
Product substitution issue 12.51 9.99 8 113592 17853 64367279
Abdominal discomfort 12.47 9.99 236 113364 182086 64203046
Ventricular tachycardia 12.46 9.99 26 113574 34239 64350893
Oxygen saturation decreased 12.36 9.99 261 113339 106915 64278217
Brief psychotic disorder with marked stressors 12.28 9.99 7 113593 264 64384868
Cystitis 12.27 9.99 122 113478 42553 64342579
Weight decreased 12.24 9.99 618 112982 285121 64100011
Extradural haematoma 12.20 9.99 19 113581 2657 64382475
Respiratory rate increased 12.08 9.99 64 113536 18267 64366865
Pain in extremity 12.07 9.99 651 112949 302434 64082698
Hypercholesterolaemia 12.04 9.99 6 113594 15367 64369765
Injection site reaction 12.00 9.99 42 113558 46622 64338510
Altered state of consciousness 11.98 9.99 31 113569 37871 64347261
Cardiac failure acute 11.89 9.99 7 113593 16337 64368795
Bone pain 11.79 9.99 132 113468 47440 64337692
Spinal laminectomy 11.77 9.99 9 113591 559 64384573
Haematotoxicity 11.77 9.99 4 113596 12892 64372240
Taste disorder 11.76 9.99 40 113560 9393 64375739
Gastrointestinal mucosa hyperaemia 11.72 9.99 8 113592 416 64384716
Swelling face 11.66 9.99 59 113541 59107 64326025
Burkholderia test positive 11.62 9.99 9 113591 570 64384562
Gallbladder disorder 11.60 9.99 60 113540 16970 64368162
Arthropathy 11.52 9.99 147 113453 120820 64264312
Haematuria 11.52 9.99 61 113539 60410 64324722
Type IIa hyperlipidaemia 11.48 9.99 6 113594 190 64384942
Infusion site granuloma 11.43 9.99 3 113597 11 64385121
Joint stiffness 11.35 9.99 92 113508 30312 64354820
Sepsis 11.31 9.99 505 113095 229836 64155296
Feeding disorder 11.28 9.99 49 113551 12900 64372232
Caesarean section 11.19 9.99 3 113597 11271 64373861
Accidental death 11.18 9.99 22 113578 3703 64381429
Respiratory tract inflammation 11.11 9.99 10 113590 780 64384352
Ejection fraction decreased 11.11 9.99 21 113579 28686 64356446
Weight fluctuation 11.11 9.99 36 113564 8246 64376886
Defaecation disorder 11.08 9.99 8 113592 455 64384677
Withdrawal hypertension 11.06 9.99 7 113593 320 64384812
Atelectasis 11.00 9.99 84 113516 27182 64357950
Foreign body reaction 10.99 9.99 5 113595 116 64385016
Anaphylactic reaction 10.99 9.99 176 113424 68488 64316644
Pulmonary hypertension 10.98 9.99 39 113561 43100 64342032
Impaired healing 10.97 9.99 62 113538 60411 64324721
Mental disorder 10.96 9.99 82 113518 26363 64358769
Metastases to liver 10.94 9.99 76 113524 23865 64361267
Pancytopenia 10.91 9.99 182 113418 143127 64242005
Mucosal inflammation 10.91 9.99 65 113535 62519 64322613
Umbilical discharge 10.83 9.99 5 113595 120 64385012
Incision site swelling 10.80 9.99 5 113595 121 64385011
Gastric infection 10.76 9.99 20 113580 3228 64381904
Bladder cancer 10.74 9.99 3 113597 10971 64374161
Cholangitis sclerosing 10.73 9.99 15 113585 1904 64383228
Angina unstable 10.73 9.99 7 113593 15460 64369672
Product storage error 10.73 9.99 5 113595 13313 64371819
Vein collapse 10.72 9.99 9 113591 640 64384492
Coccygectomy 10.68 9.99 3 113597 15 64385117
Salivary hypersecretion 10.64 9.99 4 113596 12109 64373023
Device kink 10.63 9.99 14 113586 1679 64383453
Lymphopenia 10.62 9.99 18 113582 25639 64359493
Administration related reaction 10.61 9.99 5 113595 126 64385006
Aspergillus infection 10.59 9.99 8 113592 16371 64368761
Injection site bruising 10.57 9.99 31 113569 36342 64348790
Wrong technique in product usage process 10.54 9.99 69 113531 64905 64320227
Dyspnoea 10.52 9.99 1107 112493 717567 63667565
Swelling 10.46 9.99 209 113391 160009 64225123
Mean platelet volume decreased 10.39 9.99 14 113586 1717 64383415
Scratch 10.38 9.99 30 113570 6459 64378673
Upper respiratory tract infection 10.34 9.99 183 113417 72602 64312530
Intestinal resection 10.30 9.99 19 113581 3049 64382083
Pemphigoid 10.27 9.99 5 113595 12981 64372151
Central nervous system lesion 10.26 9.99 4 113596 11845 64373287
Intestinal pseudo-obstruction 10.26 9.99 15 113585 1985 64383147
Post procedural pulmonary embolism 10.23 9.99 6 113594 239 64384893
Chronic kidney disease 10.18 9.99 60 113540 57859 64327273
Gross motor delay 10.15 9.99 4 113596 64 64385068
Fistula 10.14 9.99 39 113561 9722 64375410
Toxicity to various agents 10.11 9.99 757 112843 362756 64022376
Cerebrospinal fluid leakage 10.08 9.99 12 113588 1300 64383832
Blood triglycerides increased 10.07 9.99 11 113589 18855 64366277
Immunoglobulins decreased 10.04 9.99 12 113588 1306 64383826
Rubella 10.00 9.99 5 113595 144 64384988

FDA Adverse Event Reporting System (Pediatric)

None

Pharmacologic Action:

SourceCodeDescription
ATC N02AA03 NERVOUS SYSTEM
ANALGESICS
OPIOIDS
Natural opium alkaloids
ATC N02AA53 NERVOUS SYSTEM
ANALGESICS
OPIOIDS
Natural opium alkaloids
ATC N02AG04 NERVOUS SYSTEM
ANALGESICS
OPIOIDS
Opioids in combination with antispasmodics
MeSH PA D000700 Analgesics
MeSH PA D000701 Analgesics, Opioid
MeSH PA D002491 Central Nervous System Agents
MeSH PA D002492 Central Nervous System Depressants
MeSH PA D009294 Narcotics
MeSH PA D018373 Peripheral Nervous System Agents
MeSH PA D018689 Sensory System Agents
CHEBI has role CHEBI:35482 narcotic analgesic
CHEBI has role CHEBI:55322 mu-opioid agonists
FDA MoA N0000175684 Full Opioid Agonists
FDA EPC N0000175690 Opioid Agonist

Drug Use (View source of the data)

DiseaseRelationSNOMED_IDDOID
Pain indication 22253000
Cough indication 49727002
Severe pain indication 76948002
Common cold indication 82272006 DOID:10459
Acute postoperative pain indication 107401000119105
Severe Pain with Opioid Tolerance indication
Chronic Pain with Opioid Tolerance indication
Suicidal thoughts contraindication 6471006
Dependent drug abuse contraindication 6525002
Alcohol withdrawal delirium contraindication 8635005
Asthenia contraindication 13791008
Constipation contraindication 14760008 DOID:2089
Mood swings contraindication 18963009
Inflammatory bowel disease contraindication 24526004 DOID:0050589
Alcohol intoxication contraindication 25702006
Complete atrioventricular block contraindication 27885002
Shock contraindication 27942005
Hypercapnia contraindication 29596007
Dehydration contraindication 34095006
Disorder of gallbladder contraindication 39621005 DOID:0060262
Hypothyroidism contraindication 40930008 DOID:1459
Conduction disorder of the heart contraindication 44808001
Low blood pressure contraindication 45007003
Bradycardia contraindication 48867003
Hepatic failure contraindication 59927004
Ulcerative colitis contraindication 64766004 DOID:8577
Substance abuse contraindication 66214007
Benign intracranial hypertension contraindication 68267002 DOID:11459
Urethral stricture contraindication 76618002
Decreased respiratory function contraindication 80954004
Injury of head contraindication 82271004
Cor pulmonale contraindication 83291003 DOID:8515
Pulmonary emphysema contraindication 87433001
Kidney disease contraindication 90708001 DOID:557
Acute abdominal pain contraindication 116290004
Neoplasm of brain contraindication 126952004 DOID:1319
Seizure disorder contraindication 128613002
Drug-induced psychosis contraindication 191483003 DOID:1742
Disease of liver contraindication 235856003 DOID:409
Morbid obesity contraindication 238136002 DOID:11981
Sepsis syndrome contraindication 238150007
Benign prostatic hyperplasia contraindication 266569009
Retention of urine contraindication 267064002
Exacerbation of asthma contraindication 281239006
Lesion of brain contraindication 301766008
Deficiency of cholinesterase contraindication 360607009
Coma contraindication 371632003
Primary adrenocortical insufficiency contraindication 373662000
Operation on gastrointestinal tract contraindication 386621005
Hypoxia contraindication 389086002
Central nervous system depression contraindication 418072004
Dysfunction of sphincter of Oddi contraindication 430887001




๐Ÿถ Veterinary Drug Use

None

๐Ÿถ Veterinary products

None

Acid dissociation constants calculated using MoKa v3.0.0

Dissociation levelDissociation constantType (acidic/basic)
pKa1 9.67 acidic
pKa2 8.64 Basic

Orange Book patent data (new drug applications)

None

Orange Book exclusivity data (new drug applications)

None

Bioactivity Summary:

TargetClassPharosUniProtActionTypeActivity value
(-log[M])
Mechanism
action
Bioact sourceMoA source
Mu-type opioid receptor GPCR AGONIST Ki 9.55 CHEMBL CHEMBL
Kappa-type opioid receptor GPCR Ki 8.55 CHEMBL
Delta-type opioid receptor GPCR Ki 7.42 CHEMBL
Opioid receptor GPCR EC50 9 CHEMBL

External reference:

IDSource
4019779 VUID
N0000147870 NUI
D00839 KEGG_DRUG
71-68-1 SECONDARY_CAS_RN
4018035 VANDF
4019779 VANDF
C0012306 UMLSCUI
CHEBI:5790 CHEBI
CHEMBL398707 ChEMBL_ID
DB00327 DRUGBANK_ID
CHEMBL1237055 ChEMBL_ID
D004091 MESH_DESCRIPTOR_UI
5284570 PUBCHEM_CID
7082 IUPHAR_LIGAND_ID
1770 INN_ID
Q812464R06 UNII
203177 RXNORM
1470 MMSL
4848 MMSL
7015 MMSL
d00255 MMSL
001547 NDDF
004622 NDDF
387485001 SNOMEDCT_US
414428000 SNOMEDCT_US
44508008 SNOMEDCT_US

Pharmaceutical products:

ProductCategoryIngredientsNDCFormQuantityRouteMarketingLabel
Hydromorphone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0054-0264 TABLET 4 mg ORAL ANDA 33 sections
Hydromorphone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0054-0264 TABLET 4 mg ORAL ANDA 33 sections
Hydromorphone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0054-0265 TABLET 8 mg ORAL ANDA 33 sections
Hydromorphone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0054-0265 TABLET 8 mg ORAL ANDA 33 sections
Hydromorphone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0054-0386 SOLUTION 1 mg ORAL ANDA 33 sections
Hydromorphone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0054-0386 SOLUTION 1 mg ORAL ANDA 33 sections
Hydromorphone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0406-3243 TABLET 2 mg ORAL ANDA 37 sections
Hydromorphone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0406-3244 TABLET 4 mg ORAL ANDA 37 sections
Hydromorphone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0406-3249 TABLET 8 mg ORAL ANDA 37 sections
Hydromorphone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0409-1283 INJECTION, SOLUTION 1 mg INTRAMUSCULAR NDA 35 sections
Hydromorphone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0409-1283 INJECTION, SOLUTION 1 mg INTRAMUSCULAR NDA 35 sections
Hydromorphone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0409-1283 INJECTION, SOLUTION 1 mg INTRAMUSCULAR NDA 35 sections
Hydromorphone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0409-1304 INJECTION, SOLUTION 4 mg INTRAMUSCULAR NDA 33 sections
Hydromorphone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0409-1312 INJECTION, SOLUTION 2 mg INTRAMUSCULAR NDA 35 sections
Hydromorphone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0409-1312 INJECTION, SOLUTION 2 mg INTRAMUSCULAR NDA 35 sections
Hydromorphone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0409-1312 INJECTION, SOLUTION 2 mg INTRAMUSCULAR NDA 35 sections
Hydromorphone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0409-1380 INJECTION, SOLUTION 4 mg INTRAMUSCULAR NDA 35 sections
Hydromorphone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0409-1380 INJECTION, SOLUTION 4 mg INTRAMUSCULAR NDA 35 sections
Hydromorphone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0409-2540 INJECTION, SOLUTION 4 mg INTRAMUSCULAR NDA 33 sections
Hydromorphone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0409-2552 INJECTION, SOLUTION 1 mg INTRAMUSCULAR NDA 33 sections
Hydromorphone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0409-2634 INJECTION, SOLUTION 10 mg INTRAMUSCULAR ANDA 34 sections
Hydromorphone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0409-2634 INJECTION, SOLUTION 10 mg INTRAMUSCULAR ANDA 34 sections
Hydromorphone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0409-3356 INJECTION, SOLUTION 2 mg INTRAMUSCULAR NDA 33 sections
Hydromorphone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0409-3365 INJECTION, SOLUTION 2 mg INTRAMUSCULAR NDA 33 sections
Hydromorphone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0409-4264 INJECTION, SOLUTION 0.50 mg INTRAMUSCULAR NDA 35 sections
Hydromorphone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0527-1353 TABLET 2 mg ORAL ANDA 32 sections
Hydromorphone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0527-1354 TABLET 4 mg ORAL ANDA 32 sections
Hydromorphone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0527-1355 TABLET 8 mg ORAL ANDA 32 sections
Hydromorphone Hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0527-1873 SOLUTION 5 mg ORAL ANDA 30 sections
hydromorphone hydrochloride HUMAN PRESCRIPTION DRUG LABEL 1 0574-0293 TABLET, EXTENDED RELEASE 8 mg ORAL ANDA 33 sections