Stem definition | Drug id | CAS RN |
---|---|---|
opioid receptor antagonists/agonists, morphinan derivates | 1393 | 466-99-9 |
Dose | Unit | Route |
---|---|---|
20 | mg | O |
4 | mg | P |
4 | mg | R |
Property | Value | Reference |
---|---|---|
BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
S (Water solubility) | 10 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
EoM (Fraction excreted unchanged in urine) | 6 % | Benet LZ, Broccatelli F, Oprea TI |
MRTD (Maximum Recommended Therapeutic Daily Dose) | 1.20 ยตM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
BA (Bioavailability) | 42 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
Vd (Volume of distribution) | 4.30 L/kg | Lombardo F, Berellini G, Obach RS |
CL (Clearance) | 28 mL/min/kg | Lombardo F, Berellini G, Obach RS |
fu (Fraction unbound in plasma) | 0.86 % | Lombardo F, Berellini G, Obach RS |
t_half (Half-life) | 2.30 hours | Lombardo F, Berellini G, Obach RS |
Date | Agency | Company | Orphan |
---|---|---|---|
Jan. 11, 1984 | FDA | PURDUE PHARM PRODS |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Drug hypersensitivity | 493.84 | 9.90 | 1255 | 88575 | 249755 | 50265539 |
Temperature regulation disorder | 259.85 | 9.90 | 134 | 89696 | 4093 | 50511201 |
Food allergy | 187.99 | 9.90 | 138 | 89692 | 7999 | 50507295 |
Coeliac disease | 171.25 | 9.90 | 134 | 89696 | 8551 | 50506743 |
Pneumonia viral | 164.91 | 9.90 | 119 | 89711 | 6715 | 50508579 |
Drug withdrawal syndrome | 145.13 | 9.90 | 200 | 89630 | 24881 | 50490413 |
Pneumonia aspiration | 138.64 | 9.90 | 219 | 89611 | 30785 | 50484509 |
Bursitis | 137.95 | 9.90 | 183 | 89647 | 21952 | 50493342 |
Immunodeficiency | 137.44 | 9.90 | 150 | 89680 | 14678 | 50500616 |
Constipation | 131.94 | 9.90 | 665 | 89165 | 185043 | 50330251 |
Soft tissue disorder | 131.53 | 9.90 | 86 | 89744 | 4128 | 50511166 |
Drug dependence | 130.34 | 9.90 | 168 | 89662 | 19591 | 50495703 |
Macular degeneration | 122.11 | 9.90 | 139 | 89691 | 14249 | 50501045 |
Alopecia | 119.45 | 9.90 | 156 | 89674 | 244891 | 50270403 |
Somnolence | 114.30 | 9.90 | 561 | 89269 | 154424 | 50360870 |
Pemphigus | 106.52 | 9.90 | 40 | 89790 | 120126 | 50395168 |
Rheumatoid arthritis | 90.77 | 9.90 | 643 | 89187 | 201907 | 50313387 |
Arthritis | 89.99 | 9.90 | 348 | 89482 | 86373 | 50428921 |
Nausea | 89.03 | 9.90 | 1749 | 88081 | 703649 | 49811645 |
Systemic lupus erythematosus | 88.28 | 9.90 | 72 | 89758 | 140550 | 50374744 |
Glossodynia | 87.57 | 9.90 | 48 | 89782 | 115521 | 50399773 |
Delirium | 85.34 | 9.90 | 201 | 89629 | 37991 | 50477303 |
Hyperaesthesia | 83.37 | 9.90 | 87 | 89743 | 8086 | 50507208 |
Maternal exposure during pregnancy | 80.61 | 9.90 | 99 | 89731 | 159679 | 50355615 |
Respiratory rate decreased | 72.44 | 9.90 | 53 | 89777 | 3055 | 50512239 |
Extremity contracture | 72.23 | 9.90 | 38 | 89792 | 1210 | 50514084 |
Hypermobility syndrome | 70.80 | 9.90 | 32 | 89798 | 725 | 50514569 |
Unresponsive to stimuli | 70.47 | 9.90 | 163 | 89667 | 30446 | 50484848 |
Ankylosing spondylitis | 69.05 | 9.90 | 74 | 89756 | 7091 | 50508203 |
Oral pain | 68.63 | 9.90 | 143 | 89687 | 24890 | 50490404 |
Respiratory depression | 68.31 | 9.90 | 95 | 89735 | 11915 | 50503379 |
Vomiting | 68.21 | 9.90 | 1172 | 88658 | 459586 | 50055708 |
Back pain | 67.98 | 9.90 | 642 | 89188 | 219388 | 50295906 |
Duodenal ulcer perforation | 64.97 | 9.90 | 4 | 89826 | 45607 | 50469687 |
Lower respiratory tract infection | 64.54 | 9.90 | 45 | 89785 | 95156 | 50420138 |
Gastrooesophageal reflux disease | 61.60 | 9.90 | 284 | 89546 | 76144 | 50439150 |
Coma | 58.78 | 9.90 | 228 | 89602 | 56651 | 50458643 |
Helicobacter infection | 58.72 | 9.90 | 9 | 89821 | 49693 | 50465601 |
Overdose | 56.48 | 9.90 | 336 | 89494 | 99391 | 50415903 |
Herpes zoster | 56.28 | 9.90 | 262 | 89568 | 70524 | 50444770 |
Drug interaction | 56.07 | 9.90 | 175 | 89655 | 199446 | 50315848 |
Injection site erythema | 55.49 | 9.90 | 32 | 89798 | 74904 | 50440390 |
Abdominal discomfort | 55.06 | 9.90 | 218 | 89612 | 231423 | 50283871 |
Rash erythematous | 54.91 | 9.90 | 161 | 89669 | 34691 | 50480603 |
Pain | 54.60 | 9.90 | 1378 | 88452 | 577525 | 49937769 |
Hyperhidrosis | 54.35 | 9.90 | 307 | 89523 | 89119 | 50426175 |
Inadequate analgesia | 53.77 | 9.90 | 41 | 89789 | 2517 | 50512777 |
Muscle injury | 53.63 | 9.90 | 3 | 89827 | 37108 | 50478186 |
Rash | 51.68 | 9.90 | 512 | 89318 | 436959 | 50078335 |
Malignant neoplasm progression | 51.14 | 9.90 | 248 | 89582 | 67876 | 50447418 |
Sickle cell anaemia with crisis | 51.14 | 9.90 | 51 | 89779 | 4492 | 50510802 |
Medical device site pain | 50.79 | 9.90 | 17 | 89813 | 164 | 50515130 |
Device related thrombosis | 49.11 | 9.90 | 30 | 89800 | 1277 | 50514017 |
Pericarditis | 48.48 | 9.90 | 41 | 89789 | 78648 | 50436646 |
Narcotic bowel syndrome | 47.85 | 9.90 | 15 | 89815 | 115 | 50515179 |
Anti-cyclic citrullinated peptide antibody positive | 47.00 | 9.90 | 34 | 89796 | 70553 | 50444741 |
Joint dislocation | 46.89 | 9.90 | 81 | 89749 | 12252 | 50503042 |
Hepatic cirrhosis | 46.54 | 9.90 | 99 | 89731 | 17478 | 50497816 |
Drug diversion | 46.29 | 9.90 | 24 | 89806 | 741 | 50514553 |
Exostosis | 46.23 | 9.90 | 78 | 89752 | 11575 | 50503719 |
Breast cancer metastatic | 46.03 | 9.90 | 73 | 89757 | 10291 | 50505003 |
Hand deformity | 45.52 | 9.90 | 67 | 89763 | 100132 | 50415162 |
Intentional overdose | 44.44 | 9.90 | 28 | 89802 | 62476 | 50452818 |
Implant site extravasation | 44.17 | 9.90 | 20 | 89810 | 455 | 50514839 |
Irritable bowel syndrome | 44.11 | 9.90 | 18 | 89812 | 51423 | 50463871 |
Retinitis | 43.57 | 9.90 | 32 | 89798 | 1855 | 50513439 |
Neoplasm progression | 43.38 | 9.90 | 132 | 89698 | 29025 | 50486269 |
Arthropathy | 43.22 | 9.90 | 140 | 89690 | 157766 | 50357528 |
Exposure during pregnancy | 43.21 | 9.90 | 94 | 89736 | 120921 | 50394373 |
Folliculitis | 42.24 | 9.90 | 9 | 89821 | 39216 | 50476078 |
Hereditary angioedema | 41.87 | 9.90 | 50 | 89780 | 5392 | 50509902 |
Migraine | 40.93 | 9.90 | 251 | 89579 | 75029 | 50440265 |
Swelling | 40.49 | 9.90 | 201 | 89629 | 200671 | 50314623 |
Sleep disorder due to general medical condition, insomnia type | 38.77 | 9.90 | 5 | 89825 | 31442 | 50483852 |
Therapeutic product effect incomplete | 38.30 | 9.90 | 286 | 89544 | 91229 | 50424065 |
Blister | 37.94 | 9.90 | 58 | 89772 | 85360 | 50429934 |
Anaphylactic reaction | 37.88 | 9.90 | 193 | 89637 | 53862 | 50461432 |
Postmortem blood drug level increased | 37.36 | 9.90 | 19 | 89811 | 563 | 50514731 |
Asthma | 37.28 | 9.90 | 279 | 89551 | 89058 | 50426236 |
Bone erosion | 37.11 | 9.90 | 71 | 89759 | 11616 | 50503678 |
Osteoporosis | 37.06 | 9.90 | 168 | 89662 | 44711 | 50470583 |
Fluid retention | 37.01 | 9.90 | 183 | 89647 | 50466 | 50464828 |
Drug reaction with eosinophilia and systemic symptoms | 36.33 | 9.90 | 4 | 89826 | 28420 | 50486874 |
Injection site pain | 35.82 | 9.90 | 91 | 89739 | 110933 | 50404361 |
Myocardial infarction | 35.33 | 9.90 | 65 | 89765 | 88962 | 50426332 |
Injection site swelling | 35.20 | 9.90 | 15 | 89815 | 41758 | 50473536 |
Cardiac failure congestive | 34.94 | 9.90 | 60 | 89770 | 84322 | 50430972 |
Scar | 34.14 | 9.90 | 69 | 89761 | 11749 | 50503545 |
Rheumatoid factor negative | 33.96 | 9.90 | 18 | 89812 | 582 | 50514712 |
Abortion spontaneous | 33.63 | 9.90 | 16 | 89814 | 41756 | 50473538 |
Faecal volume decreased | 33.21 | 9.90 | 12 | 89818 | 148 | 50515146 |
Pustular psoriasis | 33.00 | 9.90 | 38 | 89792 | 3943 | 50511351 |
Product dose omission issue | 32.59 | 9.90 | 192 | 89638 | 183646 | 50331648 |
Fibromyalgia | 32.50 | 9.90 | 162 | 89668 | 44816 | 50470478 |
Hyponatraemia | 32.43 | 9.90 | 77 | 89753 | 96062 | 50419232 |
Abdominal pain | 32.34 | 9.90 | 594 | 89236 | 235634 | 50279660 |
Treatment failure | 31.74 | 9.90 | 131 | 89699 | 137506 | 50377788 |
Hypertensive encephalopathy | 31.59 | 9.90 | 17 | 89813 | 567 | 50514727 |
Alveolitis | 31.43 | 9.90 | 30 | 89800 | 2504 | 50512790 |
Small intestinal obstruction | 31.04 | 9.90 | 80 | 89750 | 15988 | 50499306 |
Overwork | 30.75 | 9.90 | 9 | 89821 | 53 | 50515241 |
Tenderness | 30.43 | 9.90 | 87 | 89743 | 18478 | 50496816 |
Neutropenia | 29.83 | 9.90 | 148 | 89682 | 147817 | 50367477 |
Acute chest syndrome | 29.72 | 9.90 | 17 | 89813 | 640 | 50514654 |
Drug abuse | 29.71 | 9.90 | 195 | 89635 | 59651 | 50455643 |
Injection site reaction | 29.69 | 9.90 | 27 | 89803 | 50005 | 50465289 |
Compartment syndrome | 29.52 | 9.90 | 26 | 89804 | 1956 | 50513338 |
Plasma cell myeloma | 29.50 | 9.90 | 122 | 89708 | 31200 | 50484094 |
Mental status changes | 29.36 | 9.90 | 135 | 89695 | 36137 | 50479157 |
Synovitis | 29.04 | 9.90 | 342 | 89488 | 123523 | 50391771 |
Injection site pruritus | 28.86 | 9.90 | 18 | 89812 | 40393 | 50474901 |
Hepatic function abnormal | 28.73 | 9.90 | 11 | 89819 | 32670 | 50482624 |
Hepatitis | 28.65 | 9.90 | 10 | 89820 | 31443 | 50483851 |
Renal impairment | 28.49 | 9.90 | 57 | 89773 | 75604 | 50439690 |
Obstruction | 28.11 | 9.90 | 26 | 89804 | 2085 | 50513209 |
Head banging | 27.96 | 9.90 | 14 | 89816 | 401 | 50514893 |
Hypoaesthesia | 27.93 | 9.90 | 347 | 89483 | 126910 | 50388384 |
Interstitial lung disease | 27.80 | 9.90 | 32 | 89798 | 53144 | 50462150 |
Sinusitis | 27.71 | 9.90 | 183 | 89647 | 170375 | 50344919 |
Immunoglobulins decreased | 27.65 | 9.90 | 19 | 89811 | 991 | 50514303 |
Rhesus antigen positive | 27.63 | 9.90 | 10 | 89820 | 124 | 50515170 |
Blepharospasm | 27.62 | 9.90 | 30 | 89800 | 2918 | 50512376 |
Platelet aggregation inhibition | 27.48 | 9.90 | 10 | 89820 | 126 | 50515168 |
Tissue infiltration | 26.88 | 9.90 | 15 | 89815 | 538 | 50514756 |
Bursitis infective | 26.42 | 9.90 | 20 | 89810 | 1214 | 50514080 |
Sedation | 26.33 | 9.90 | 116 | 89714 | 30494 | 50484800 |
Foetal exposure during pregnancy | 26.15 | 9.90 | 8 | 89822 | 27351 | 50487943 |
Pregnancy | 25.93 | 9.90 | 10 | 89820 | 29567 | 50485727 |
Hepatocellular injury | 25.88 | 9.90 | 7 | 89823 | 25940 | 50489354 |
Blood pressure systolic increased | 25.84 | 9.90 | 128 | 89702 | 35321 | 50479973 |
Orthostatic hypotension | 25.79 | 9.90 | 10 | 89820 | 29471 | 50485823 |
Basal ganglion degeneration | 25.26 | 9.90 | 13 | 89817 | 395 | 50514899 |
Post procedural complication | 24.97 | 9.90 | 71 | 89759 | 15033 | 50500261 |
Procedural pain | 24.82 | 9.90 | 67 | 89763 | 13765 | 50501529 |
Respiratory syncytial virus infection | 24.14 | 9.90 | 37 | 89793 | 5065 | 50510229 |
Monoplegia | 23.80 | 9.90 | 27 | 89803 | 2756 | 50512538 |
Lactic acidosis | 23.63 | 9.90 | 15 | 89815 | 33340 | 50481954 |
Intentional self-injury | 23.50 | 9.90 | 6 | 89824 | 23106 | 50492188 |
Cardiac failure | 23.25 | 9.90 | 64 | 89766 | 75976 | 50439318 |
Bronchomalacia | 22.73 | 9.90 | 10 | 89820 | 212 | 50515082 |
Red cell distribution width increased | 22.42 | 9.90 | 48 | 89782 | 8511 | 50506783 |
Screaming | 22.32 | 9.90 | 27 | 89803 | 2951 | 50512343 |
Bradycardia | 22.20 | 9.90 | 51 | 89779 | 64375 | 50450919 |
Acute kidney injury | 21.69 | 9.90 | 280 | 89550 | 227778 | 50287516 |
Vaginal flatulence | 21.52 | 9.90 | 10 | 89820 | 242 | 50515052 |
Localised infection | 21.48 | 9.90 | 96 | 89734 | 25389 | 50489905 |
Amputation stump pain | 21.15 | 9.90 | 6 | 89824 | 31 | 50515263 |
Malignant polyp | 21.08 | 9.90 | 9 | 89821 | 177 | 50515117 |
Ligament pain | 20.89 | 9.90 | 9 | 89821 | 181 | 50515113 |
Foot deformity | 20.65 | 9.90 | 78 | 89752 | 19132 | 50496162 |
Spinal cord compression | 20.58 | 9.90 | 29 | 89801 | 3680 | 50511614 |
Virologic failure | 20.32 | 9.90 | 19 | 89811 | 1545 | 50513749 |
Extradural haematoma | 20.08 | 9.90 | 19 | 89811 | 1568 | 50513726 |
Rheumatic fever | 20.04 | 9.90 | 3 | 89827 | 16864 | 50498430 |
Cholestasis | 20.04 | 9.90 | 10 | 89820 | 25391 | 50489903 |
Taste disorder | 19.90 | 9.90 | 45 | 89785 | 8279 | 50507015 |
Knee arthroplasty | 19.36 | 9.90 | 21 | 89809 | 35825 | 50479469 |
Apnoea | 19.33 | 9.90 | 40 | 89790 | 6926 | 50508368 |
Drug eruption | 19.07 | 9.90 | 9 | 89821 | 23597 | 50491697 |
Photophobia | 19.04 | 9.90 | 64 | 89766 | 14823 | 50500471 |
Balance disorder | 19.01 | 9.90 | 63 | 89767 | 70527 | 50444767 |
Rash pruritic | 18.92 | 9.90 | 35 | 89795 | 47811 | 50467483 |
Pancreatitis | 18.86 | 9.90 | 135 | 89695 | 42479 | 50472815 |
Foreign body embolism | 18.58 | 9.90 | 4 | 89826 | 4 | 50515290 |
Hip arthroplasty | 18.56 | 9.90 | 16 | 89814 | 30413 | 50484881 |
Infusion site mass | 18.49 | 9.90 | 16 | 89814 | 1176 | 50514118 |
Blood immunoglobulin M decreased | 18.39 | 9.90 | 13 | 89817 | 710 | 50514584 |
Accidental overdose | 18.33 | 9.90 | 76 | 89754 | 19457 | 50495837 |
Dry eye | 18.24 | 9.90 | 18 | 89812 | 32077 | 50483217 |
Premature baby | 18.19 | 9.90 | 5 | 89825 | 18332 | 50496962 |
Anaesthesia | 18.14 | 9.90 | 10 | 89820 | 350 | 50514944 |
Tumour pain | 18.05 | 9.90 | 16 | 89814 | 1214 | 50514080 |
Limb mass | 18.04 | 9.90 | 23 | 89807 | 2652 | 50512642 |
Drug tolerance | 18.03 | 9.90 | 32 | 89798 | 4944 | 50510350 |
Uterine enlargement | 17.95 | 9.90 | 15 | 89815 | 1051 | 50514243 |
Hypocalcaemia | 17.74 | 9.90 | 13 | 89817 | 26803 | 50488491 |
Ocular procedural complication | 17.64 | 9.90 | 10 | 89820 | 370 | 50514924 |
Impaired healing | 17.63 | 9.90 | 64 | 89766 | 69722 | 50445572 |
Antidepressant drug level above therapeutic | 17.57 | 9.90 | 10 | 89820 | 373 | 50514921 |
Poor venous access | 17.48 | 9.90 | 49 | 89781 | 10291 | 50505003 |
Upper respiratory tract infection | 17.27 | 9.90 | 186 | 89644 | 65712 | 50449582 |
Drug ineffective | 17.24 | 9.90 | 1682 | 88148 | 817651 | 49697643 |
Substance dependence | 17.12 | 9.90 | 8 | 89822 | 196 | 50515098 |
Red blood cell sedimentation rate abnormal | 17.09 | 9.90 | 4 | 89826 | 16339 | 50498955 |
Intestinal obstruction | 16.96 | 9.90 | 92 | 89738 | 26291 | 50489003 |
Swollen joint count increased | 16.88 | 9.90 | 3 | 89827 | 14870 | 50500424 |
Eye disorder | 16.87 | 9.90 | 72 | 89758 | 18667 | 50496627 |
Metastases to bone | 16.87 | 9.90 | 70 | 89760 | 17925 | 50497369 |
Eye operation | 16.86 | 9.90 | 19 | 89811 | 1925 | 50513369 |
Wrong technique in product usage process | 16.76 | 9.90 | 47 | 89783 | 55463 | 50459831 |
Blood pressure fluctuation | 16.74 | 9.90 | 115 | 89715 | 35708 | 50479586 |
No adverse event | 16.71 | 9.90 | 21 | 89809 | 33557 | 50481737 |
Vitamin K deficiency | 16.64 | 9.90 | 10 | 89820 | 413 | 50514881 |
Syncope | 16.47 | 9.90 | 111 | 89719 | 102891 | 50412403 |
Biliary tract infection | 16.28 | 9.90 | 10 | 89820 | 430 | 50514864 |
Cholangitis sclerosing | 16.10 | 9.90 | 15 | 89815 | 1214 | 50514080 |
Caesarean section | 16.02 | 9.90 | 4 | 89826 | 15635 | 50499659 |
Neuralgia | 15.97 | 9.90 | 79 | 89751 | 21784 | 50493510 |
Dental caries | 15.94 | 9.90 | 46 | 89784 | 9821 | 50505473 |
Cytomegalovirus infection | 15.87 | 9.90 | 6 | 89824 | 17956 | 50497338 |
Radiation necrosis | 15.85 | 9.90 | 9 | 89821 | 334 | 50514960 |
Emotional distress | 15.84 | 9.90 | 96 | 89734 | 28567 | 50486727 |
Cystitis | 15.75 | 9.90 | 134 | 89696 | 44430 | 50470864 |
Respiratory failure | 15.65 | 9.90 | 238 | 89592 | 90943 | 50424351 |
Gait inability | 15.64 | 9.90 | 116 | 89714 | 36911 | 50478383 |
Respiratory arrest | 15.64 | 9.90 | 99 | 89731 | 29910 | 50485384 |
Dyspnoea | 15.61 | 9.90 | 804 | 89026 | 546804 | 49968490 |
Substance abuse | 15.56 | 9.90 | 27 | 89803 | 4097 | 50511197 |
Carbohydrate antigen 19-9 increased | 15.43 | 9.90 | 7 | 89823 | 160 | 50515134 |
Toxicologic test abnormal | 15.38 | 9.90 | 11 | 89819 | 612 | 50514682 |
Live birth | 15.32 | 9.90 | 5 | 89825 | 16403 | 50498891 |
COVID-19 | 15.23 | 9.90 | 38 | 89792 | 46624 | 50468670 |
Accidental death | 15.05 | 9.90 | 17 | 89813 | 1727 | 50513567 |
Groin pain | 14.89 | 9.90 | 42 | 89788 | 8849 | 50506445 |
Psoriatic arthropathy | 14.81 | 9.90 | 39 | 89791 | 46993 | 50468301 |
Multiple sclerosis relapse | 14.81 | 9.90 | 34 | 89796 | 42930 | 50472364 |
Foreign body reaction | 14.78 | 9.90 | 5 | 89825 | 50 | 50515244 |
Incorrect route of product administration | 14.76 | 9.90 | 69 | 89761 | 18597 | 50496697 |
Adiposis dolorosa | 14.75 | 9.90 | 8 | 89822 | 271 | 50515023 |
Erythema | 14.72 | 9.90 | 352 | 89478 | 146062 | 50369232 |
Status epilepticus | 14.59 | 9.90 | 3 | 89827 | 13403 | 50501891 |
Liver function test abnormal | 14.46 | 9.90 | 131 | 89699 | 44208 | 50471086 |
Pulmonary embolism | 14.33 | 9.90 | 257 | 89573 | 101447 | 50413847 |
Alanine aminotransferase increased | 14.24 | 9.90 | 95 | 89735 | 88264 | 50427030 |
Iodine allergy | 14.22 | 9.90 | 11 | 89819 | 690 | 50514604 |
Inappropriate antidiuretic hormone secretion | 14.18 | 9.90 | 3 | 89827 | 13140 | 50502154 |
Atelectasis | 14.05 | 9.90 | 67 | 89763 | 18203 | 50497091 |
Toe amputation | 14.04 | 9.90 | 17 | 89813 | 1860 | 50513434 |
White blood cell count decreased | 13.97 | 9.90 | 136 | 89694 | 116586 | 50398708 |
Silicon granuloma | 13.93 | 9.90 | 3 | 89827 | 3 | 50515291 |
Cough | 13.93 | 9.90 | 324 | 89506 | 240940 | 50274354 |
Laryngitis | 13.93 | 9.90 | 47 | 89783 | 10909 | 50504385 |
Urticaria | 13.86 | 9.90 | 155 | 89675 | 129406 | 50385888 |
Wound | 13.63 | 9.90 | 121 | 89709 | 105673 | 50409621 |
Rheumatoid nodule | 13.55 | 9.90 | 3 | 89827 | 12732 | 50502562 |
Cerebrospinal fluid leakage | 13.43 | 9.90 | 12 | 89818 | 920 | 50514374 |
Suicide attempt | 13.36 | 9.90 | 47 | 89783 | 51685 | 50463609 |
Osteoarthritis | 13.33 | 9.90 | 183 | 89647 | 68423 | 50446871 |
Ill-defined disorder | 13.23 | 9.90 | 51 | 89779 | 54603 | 50460691 |
Opiates positive | 13.21 | 9.90 | 8 | 89822 | 335 | 50514959 |
Postoperative ileus | 13.17 | 9.90 | 9 | 89821 | 465 | 50514829 |
Eye irritation | 13.14 | 9.90 | 7 | 89823 | 17133 | 50498161 |
Rheumatoid factor positive | 13.08 | 9.90 | 45 | 89785 | 49814 | 50465480 |
Visual acuity reduced | 13.01 | 9.90 | 10 | 89820 | 20129 | 50495165 |
Death | 13.01 | 9.90 | 704 | 89126 | 324675 | 50190619 |
Implant site haematoma | 13.01 | 9.90 | 5 | 89825 | 74 | 50515220 |
Device infusion issue | 12.96 | 9.90 | 14 | 89816 | 1353 | 50513941 |
Eastern Cooperative Oncology Group performance status worsened | 12.91 | 9.90 | 10 | 89820 | 628 | 50514666 |
Mucosal inflammation | 12.86 | 9.90 | 33 | 89797 | 40109 | 50475185 |
Toxic leukoencephalopathy | 12.85 | 9.90 | 10 | 89820 | 633 | 50514661 |
Angioedema | 12.84 | 9.90 | 30 | 89800 | 37646 | 50477648 |
Electrocardiogram QT prolonged | 12.83 | 9.90 | 48 | 89782 | 51838 | 50463456 |
Ileus | 12.83 | 9.90 | 52 | 89778 | 13177 | 50502117 |
Pneumocystis jirovecii pneumonia | 12.78 | 9.90 | 5 | 89825 | 14658 | 50500636 |
Sopor | 12.68 | 9.90 | 10 | 89820 | 19869 | 50495425 |
Discomfort | 12.67 | 9.90 | 127 | 89703 | 108253 | 50407041 |
Aptyalism | 12.66 | 9.90 | 9 | 89821 | 496 | 50514798 |
Drug intolerance | 12.65 | 9.90 | 492 | 89338 | 218612 | 50296682 |
Weight decreased | 12.58 | 9.90 | 496 | 89334 | 220749 | 50294545 |
Perineal pain | 12.57 | 9.90 | 7 | 89823 | 250 | 50515044 |
Intestinal perforation | 12.49 | 9.90 | 44 | 89786 | 10435 | 50504859 |
Psychiatric symptom | 12.40 | 9.90 | 26 | 89804 | 4544 | 50510750 |
Tachyphylaxis | 12.40 | 9.90 | 7 | 89823 | 257 | 50515037 |
Eosinophilia | 12.39 | 9.90 | 9 | 89821 | 18643 | 50496651 |
Apnoeic attack | 12.37 | 9.90 | 7 | 89823 | 258 | 50515036 |
Mental disorder | 12.37 | 9.90 | 74 | 89756 | 21917 | 50493377 |
Infection | 12.37 | 9.90 | 398 | 89432 | 172556 | 50342738 |
Skin laceration | 12.31 | 9.90 | 66 | 89764 | 18776 | 50496518 |
Mucous stools | 12.28 | 9.90 | 20 | 89810 | 2882 | 50512412 |
Device failure | 12.24 | 9.90 | 29 | 89801 | 5499 | 50509795 |
Therapeutic product effect decreased | 12.20 | 9.90 | 169 | 89661 | 135881 | 50379413 |
Pruritus | 12.19 | 9.90 | 397 | 89433 | 283171 | 50232123 |
Mitral valve incompetence | 12.18 | 9.90 | 8 | 89822 | 17463 | 50497831 |
Swollen tongue | 12.18 | 9.90 | 20 | 89810 | 28610 | 50486684 |
Multiple organ dysfunction syndrome | 12.17 | 9.90 | 47 | 89783 | 50290 | 50465004 |
Melaena | 12.16 | 9.90 | 18 | 89812 | 26846 | 50488448 |
Respiratory tract inflammation | 12.12 | 9.90 | 9 | 89821 | 531 | 50514763 |
Implant site pain | 12.10 | 9.90 | 17 | 89813 | 2152 | 50513142 |
Klebsiella infection | 12.07 | 9.90 | 34 | 89796 | 7160 | 50508134 |
Defaecation disorder | 12.04 | 9.90 | 9 | 89821 | 536 | 50514758 |
Inguinal hernia | 12.03 | 9.90 | 15 | 89815 | 1691 | 50513603 |
Bone marrow failure | 12.03 | 9.90 | 19 | 89811 | 27605 | 50487689 |
Ocular hyperaemia | 11.98 | 9.90 | 11 | 89819 | 20281 | 50495013 |
Injection site bruising | 11.96 | 9.90 | 30 | 89800 | 36738 | 50478556 |
Abdominal tenderness | 11.82 | 9.90 | 34 | 89796 | 7246 | 50508048 |
Anaesthetic complication neurological | 11.79 | 9.90 | 6 | 89824 | 178 | 50515116 |
Palpitations | 11.78 | 9.90 | 109 | 89721 | 94397 | 50420897 |
Withdrawal syndrome | 11.76 | 9.90 | 62 | 89768 | 17528 | 50497766 |
Implant site infection | 11.74 | 9.90 | 11 | 89819 | 897 | 50514397 |
Injection site warmth | 11.65 | 9.90 | 5 | 89825 | 13861 | 50501433 |
Hypertension | 11.54 | 9.90 | 286 | 89544 | 210917 | 50304377 |
Ischaemic stroke | 11.53 | 9.90 | 7 | 89823 | 15941 | 50499353 |
Heart rate increased | 11.52 | 9.90 | 197 | 89633 | 77053 | 50438241 |
Intestinal pseudo-obstruction | 11.45 | 9.90 | 10 | 89820 | 744 | 50514550 |
Lupus-like syndrome | 11.44 | 9.90 | 40 | 89790 | 9451 | 50505843 |
Pulmonary fibrosis | 11.43 | 9.90 | 16 | 89814 | 24421 | 50490873 |
Inappropriate schedule of product administration | 11.38 | 9.90 | 185 | 89645 | 71646 | 50443648 |
Blood triglycerides increased | 11.38 | 9.90 | 3 | 89827 | 11309 | 50503985 |
Cholangitis infective | 11.35 | 9.90 | 6 | 89824 | 193 | 50515101 |
Psychogenic seizure | 11.28 | 9.90 | 14 | 89816 | 1571 | 50513723 |
Miliaria | 11.28 | 9.90 | 11 | 89819 | 943 | 50514351 |
Seasonal allergy | 11.24 | 9.90 | 6 | 89824 | 14670 | 50500624 |
Umbilical discharge | 11.24 | 9.90 | 5 | 89825 | 109 | 50515185 |
Gastrointestinal haemorrhage | 11.23 | 9.90 | 80 | 89750 | 73241 | 50442053 |
Irregular breathing | 11.23 | 9.90 | 7 | 89823 | 309 | 50514985 |
Device computer issue | 11.20 | 9.90 | 3 | 89827 | 12 | 50515282 |
Bacteraemia | 11.15 | 9.90 | 53 | 89777 | 14380 | 50500914 |
Monoclonal gammopathy | 11.10 | 9.90 | 9 | 89821 | 604 | 50514690 |
Leukopenia | 11.10 | 9.90 | 175 | 89655 | 67353 | 50447941 |
Treatment noncompliance | 11.10 | 9.90 | 23 | 89807 | 30127 | 50485167 |
Soft tissue swelling | 11.07 | 9.90 | 11 | 89819 | 965 | 50514329 |
Intestinal metastasis | 11.03 | 9.90 | 5 | 89825 | 114 | 50515180 |
Hypoxia | 11.03 | 9.90 | 139 | 89691 | 50984 | 50464310 |
Rib fracture | 11.02 | 9.90 | 65 | 89765 | 19156 | 50496138 |
Ejection fraction decreased | 10.98 | 9.90 | 10 | 89820 | 18510 | 50496784 |
Intestinal resection | 10.96 | 9.90 | 17 | 89813 | 2350 | 50512944 |
Drug ineffective for unapproved indication | 10.96 | 9.90 | 70 | 89760 | 21211 | 50494083 |
Product storage error | 10.94 | 9.90 | 4 | 89826 | 12220 | 50503074 |
Hyperkalaemia | 10.93 | 9.90 | 46 | 89784 | 48043 | 50467251 |
Encephalitis brain stem | 10.87 | 9.90 | 5 | 89825 | 118 | 50515176 |
Nerve block | 10.80 | 9.90 | 8 | 89822 | 470 | 50514824 |
Chronic gastrointestinal bleeding | 10.80 | 9.90 | 5 | 89825 | 120 | 50515174 |
Transient ischaemic attack | 10.69 | 9.90 | 26 | 89804 | 32184 | 50483110 |
Coccygectomy | 10.66 | 9.90 | 3 | 89827 | 15 | 50515279 |
Abdominal hernia | 10.65 | 9.90 | 24 | 89806 | 4405 | 50510889 |
Joint stiffness | 10.64 | 9.90 | 91 | 89739 | 30217 | 50485077 |
Hypothermia | 10.64 | 9.90 | 4 | 89826 | 12012 | 50503282 |
Failure to thrive | 10.62 | 9.90 | 30 | 89800 | 6328 | 50508966 |
Speech disorder | 10.58 | 9.90 | 103 | 89727 | 35445 | 50479849 |
Device power source issue | 10.52 | 9.90 | 8 | 89822 | 489 | 50514805 |
General physical health deterioration | 10.50 | 9.90 | 329 | 89501 | 142105 | 50373189 |
Pseudostroke | 10.50 | 9.90 | 3 | 89827 | 16 | 50515278 |
Diaphragmatic hernia | 10.47 | 9.90 | 7 | 89823 | 349 | 50514945 |
Hypersplenism | 10.46 | 9.90 | 6 | 89824 | 227 | 50515067 |
Dyspnoea exertional | 10.45 | 9.90 | 51 | 89779 | 51182 | 50464112 |
Intervertebral disc protrusion | 10.45 | 9.90 | 67 | 89763 | 20326 | 50494968 |
Respiratory rate increased | 10.45 | 9.90 | 44 | 89786 | 11341 | 50503953 |
Toxicity to various agents | 10.41 | 9.90 | 469 | 89361 | 212030 | 50303264 |
Product substitution issue | 10.40 | 9.90 | 6 | 89824 | 14051 | 50501243 |
Wound infection bacterial | 10.39 | 9.90 | 8 | 89822 | 498 | 50514796 |
Blood glucose increased | 10.36 | 9.90 | 79 | 89751 | 71245 | 50444049 |
Diarrhoea | 10.33 | 9.90 | 902 | 88928 | 587574 | 49927720 |
Extrapyramidal disorder | 10.28 | 9.90 | 4 | 89826 | 11766 | 50503528 |
Cerebral infarction | 10.25 | 9.90 | 14 | 89816 | 21590 | 50493704 |
Basal cell carcinoma | 10.23 | 9.90 | 16 | 89814 | 23340 | 50491954 |
Product name confusion | 10.18 | 9.90 | 4 | 89826 | 63 | 50515231 |
Blood albumin increased | 10.18 | 9.90 | 10 | 89820 | 865 | 50514429 |
Heart rate irregular | 10.17 | 9.90 | 64 | 89766 | 19296 | 50495998 |
Allodynia | 10.15 | 9.90 | 9 | 89821 | 683 | 50514611 |
Spinal pain | 10.11 | 9.90 | 42 | 89788 | 10761 | 50504533 |
Bone pain | 10.01 | 9.90 | 128 | 89702 | 47101 | 50468193 |
Pancreatolithiasis | 10.00 | 9.90 | 6 | 89824 | 247 | 50515047 |
Hypopnoea | 9.97 | 9.90 | 16 | 89814 | 2277 | 50513017 |
Hypercapnia | 9.95 | 9.90 | 24 | 89806 | 4603 | 50510691 |
Renal cyst | 9.95 | 9.90 | 36 | 89794 | 8651 | 50506643 |
Functional residual capacity decreased | 9.90 | 9.90 | 4 | 89826 | 68 | 50515226 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Drug dependence | 237.05 | 10.86 | 226 | 47555 | 20755 | 29505991 |
Appendicolith | 138.10 | 10.86 | 80 | 47701 | 3400 | 29523346 |
Drug withdrawal syndrome | 137.09 | 10.86 | 157 | 47624 | 17827 | 29508919 |
Pain | 131.13 | 10.86 | 586 | 47195 | 170846 | 29355900 |
Nausea | 111.43 | 10.86 | 823 | 46958 | 288432 | 29238314 |
Hyperaesthesia | 104.88 | 10.86 | 67 | 47714 | 3402 | 29523344 |
Sedation | 103.46 | 10.86 | 134 | 47647 | 17271 | 29509475 |
Constipation | 93.04 | 10.86 | 398 | 47383 | 113762 | 29412984 |
Appendicitis | 86.86 | 10.86 | 88 | 47693 | 8691 | 29518055 |
Stress | 81.80 | 10.86 | 134 | 47647 | 21356 | 29505390 |
Respiratory depression | 72.50 | 10.86 | 99 | 47682 | 13424 | 29513322 |
Vomiting | 69.91 | 10.86 | 583 | 47198 | 211677 | 29315069 |
Drug tolerance | 68.62 | 10.86 | 43 | 47738 | 2110 | 29524636 |
Victim of child abuse | 64.07 | 10.86 | 30 | 47751 | 815 | 29525931 |
Toxicologic test abnormal | 63.47 | 10.86 | 26 | 47755 | 507 | 29526239 |
Abdominal pain | 61.79 | 10.86 | 402 | 47379 | 134955 | 29391791 |
Postmortem blood drug level abnormal | 58.98 | 10.86 | 21 | 47760 | 274 | 29526472 |
Inadequate analgesia | 53.63 | 10.86 | 40 | 47741 | 2614 | 29524132 |
Back pain | 51.77 | 10.86 | 312 | 47469 | 101972 | 29424774 |
Abdominal distension | 49.50 | 10.86 | 175 | 47606 | 45736 | 29481010 |
Medical device site pain | 48.08 | 10.86 | 13 | 47768 | 61 | 29526685 |
Drug interaction | 46.09 | 10.86 | 164 | 47617 | 197221 | 29329525 |
Cardiogenic shock | 45.84 | 10.86 | 98 | 47683 | 19092 | 29507654 |
Chest injury | 44.12 | 10.86 | 28 | 47753 | 1405 | 29525341 |
Serotonin syndrome | 41.33 | 10.86 | 89 | 47692 | 17423 | 29509323 |
Myoclonus | 40.23 | 10.86 | 75 | 47706 | 13234 | 29513512 |
Drug abuse | 39.96 | 10.86 | 243 | 47538 | 79640 | 29447106 |
Painful respiration | 38.81 | 10.86 | 24 | 47757 | 1150 | 29525596 |
Respiratory rate decreased | 38.60 | 10.86 | 29 | 47752 | 1916 | 29524830 |
Arachnoiditis | 38.27 | 10.86 | 16 | 47765 | 329 | 29526417 |
Drug hypersensitivity | 38.04 | 10.86 | 214 | 47567 | 68192 | 29458554 |
Cardiac failure | 37.15 | 10.86 | 44 | 47737 | 79243 | 29447503 |
Product prescribing error | 36.44 | 10.86 | 86 | 47695 | 17890 | 29508856 |
Walking aid user | 36.12 | 10.86 | 25 | 47756 | 1452 | 29525294 |
Device power source issue | 35.86 | 10.86 | 15 | 47766 | 309 | 29526437 |
Ascites | 34.77 | 10.86 | 134 | 47647 | 36485 | 29490261 |
Plasma cell myeloma | 34.58 | 10.86 | 135 | 47646 | 36980 | 29489766 |
Postoperative ileus | 34.46 | 10.86 | 18 | 47763 | 622 | 29526124 |
Interstitial lung disease | 34.09 | 10.86 | 26 | 47755 | 57692 | 29469054 |
Prostate cancer metastatic | 33.92 | 10.86 | 41 | 47740 | 4925 | 29521821 |
Substance abuse | 33.85 | 10.86 | 48 | 47733 | 6739 | 29520007 |
Unresponsive to stimuli | 33.54 | 10.86 | 103 | 47678 | 25023 | 29501723 |
Mental status changes | 32.51 | 10.86 | 127 | 47654 | 34800 | 29491946 |
Epidural lipomatosis | 29.96 | 10.86 | 17 | 47764 | 694 | 29526052 |
Xyphoid retraction | 29.68 | 10.86 | 11 | 47770 | 162 | 29526584 |
Acute kidney injury | 29.62 | 10.86 | 280 | 47501 | 264987 | 29261759 |
Hyperhidrosis | 28.96 | 10.86 | 191 | 47590 | 64349 | 29462397 |
Myocardial infarction | 28.91 | 10.86 | 87 | 47694 | 110209 | 29416537 |
Delirium | 28.71 | 10.86 | 133 | 47648 | 39264 | 29487482 |
Drug tolerance increased | 27.76 | 10.86 | 14 | 47767 | 449 | 29526297 |
Product dose omission issue | 27.49 | 10.86 | 73 | 47708 | 96310 | 29430436 |
Seizure like phenomena | 26.47 | 10.86 | 15 | 47766 | 611 | 29526135 |
General physical health deterioration | 26.37 | 10.86 | 268 | 47513 | 102589 | 29424157 |
Systemic infection | 26.34 | 10.86 | 24 | 47757 | 2077 | 29524669 |
Opiates positive | 26.18 | 10.86 | 14 | 47767 | 508 | 29526238 |
Anaesthetic complication neurological | 26.08 | 10.86 | 12 | 47769 | 313 | 29526433 |
Confusional state | 25.87 | 10.86 | 318 | 47463 | 127559 | 29399187 |
Cardiac failure congestive | 25.01 | 10.86 | 54 | 47727 | 76527 | 29450219 |
Respiratory arrest | 24.90 | 10.86 | 95 | 47686 | 25738 | 29501008 |
Substance dependence | 24.84 | 10.86 | 12 | 47769 | 350 | 29526396 |
Immune-mediated hepatitis | 24.33 | 10.86 | 20 | 47761 | 1507 | 29525239 |
Malignant neoplasm progression | 24.26 | 10.86 | 203 | 47578 | 73656 | 29453090 |
Hepatic function abnormal | 24.07 | 10.86 | 17 | 47764 | 39242 | 29487504 |
Withdrawal syndrome | 23.83 | 10.86 | 54 | 47727 | 10938 | 29515808 |
Child abuse | 23.26 | 10.86 | 10 | 47771 | 221 | 29526525 |
Overdose | 22.92 | 10.86 | 213 | 47568 | 79606 | 29447140 |
Hyponatraemia | 22.81 | 10.86 | 187 | 47594 | 67446 | 29459300 |
Renal failure | 22.34 | 10.86 | 107 | 47674 | 118492 | 29408254 |
Oesophageal infection | 21.48 | 10.86 | 10 | 47771 | 268 | 29526478 |
Cerebral haemorrhage | 21.48 | 10.86 | 12 | 47769 | 31414 | 29495332 |
Rhabdomyolysis | 21.45 | 10.86 | 41 | 47740 | 60767 | 29465979 |
Lymphoedema | 21.38 | 10.86 | 27 | 47754 | 3390 | 29523356 |
Congenital megaureter | 21.04 | 10.86 | 8 | 47773 | 127 | 29526619 |
Pelvic pain | 20.85 | 10.86 | 21 | 47760 | 2058 | 29524688 |
Blood creatine phosphokinase increased | 20.75 | 10.86 | 21 | 47760 | 40623 | 29486123 |
Death | 20.54 | 10.86 | 709 | 47072 | 341375 | 29185371 |
Apnoeic attack | 20.38 | 10.86 | 10 | 47771 | 302 | 29526444 |
Sickle cell anaemia with crisis | 20.25 | 10.86 | 23 | 47758 | 2585 | 29524161 |
Drug reaction with eosinophilia and systemic symptoms | 20.15 | 10.86 | 10 | 47771 | 27982 | 29498764 |
Juvenile idiopathic arthritis | 19.62 | 10.86 | 17 | 47764 | 1377 | 29525369 |
Hallucination | 19.25 | 10.86 | 131 | 47650 | 44581 | 29482165 |
Forced expiratory flow decreased | 19.25 | 10.86 | 8 | 47773 | 162 | 29526584 |
Electrocardiogram QT prolonged | 19.22 | 10.86 | 18 | 47763 | 36119 | 29490627 |
Eosinophilia | 19.10 | 10.86 | 6 | 47775 | 22155 | 29504591 |
Device kink | 18.85 | 10.86 | 10 | 47771 | 357 | 29526389 |
Neutropenia | 18.80 | 10.86 | 130 | 47651 | 131581 | 29395165 |
Syncope | 18.68 | 10.86 | 68 | 47713 | 81303 | 29445443 |
Poor venous access | 18.25 | 10.86 | 24 | 47757 | 3137 | 29523609 |
Haemorrhoids thrombosed | 18.19 | 10.86 | 8 | 47773 | 187 | 29526559 |
Hypersomnia | 18.16 | 10.86 | 48 | 47733 | 10706 | 29516040 |
Microembolism | 18.07 | 10.86 | 5 | 47776 | 26 | 29526720 |
Foreign body embolism | 18.06 | 10.86 | 4 | 47777 | 6 | 29526740 |
Muscle spasticity | 17.97 | 10.86 | 30 | 47751 | 4853 | 29521893 |
Lethargy | 17.94 | 10.86 | 113 | 47668 | 37467 | 29489279 |
Pancreatic carcinoma metastatic | 17.83 | 10.86 | 22 | 47759 | 2699 | 29524047 |
Delirium tremens | 17.83 | 10.86 | 11 | 47770 | 525 | 29526221 |
Neuralgia | 17.82 | 10.86 | 48 | 47733 | 10826 | 29515920 |
Needle issue | 17.54 | 10.86 | 29 | 47752 | 4654 | 29522092 |
Oesophageal mucosa erythema | 17.47 | 10.86 | 5 | 47776 | 30 | 29526716 |
Sputum discoloured | 17.41 | 10.86 | 35 | 47746 | 6528 | 29520218 |
Renal impairment | 17.36 | 10.86 | 70 | 47711 | 81263 | 29445483 |
Coronary artery disease | 17.21 | 10.86 | 28 | 47753 | 44162 | 29482584 |
Blood pressure systolic increased | 17.11 | 10.86 | 63 | 47718 | 16782 | 29509964 |
Axillary pain | 17.10 | 10.86 | 9 | 47772 | 316 | 29526430 |
Hypoxia | 17.06 | 10.86 | 133 | 47648 | 47246 | 29479500 |
Bradycardia | 17.01 | 10.86 | 52 | 47729 | 65577 | 29461169 |
Mucosal atrophy | 17.01 | 10.86 | 6 | 47775 | 76 | 29526670 |
Spinal shock | 16.93 | 10.86 | 5 | 47776 | 34 | 29526712 |
Intentional product use issue | 16.82 | 10.86 | 122 | 47659 | 42376 | 29484370 |
Urinary tract disorder | 16.66 | 10.86 | 18 | 47763 | 1914 | 29524832 |
Hot flush | 16.28 | 10.86 | 57 | 47724 | 14813 | 29511933 |
Antasthmatic drug level | 16.23 | 10.86 | 5 | 47776 | 40 | 29526706 |
Analgesic drug level | 16.23 | 10.86 | 5 | 47776 | 40 | 29526706 |
Hepatocellular injury | 16.20 | 10.86 | 7 | 47774 | 21236 | 29505510 |
Lactic acidosis | 16.16 | 10.86 | 15 | 47766 | 30232 | 29496514 |
Infusion site mass | 16.02 | 10.86 | 8 | 47773 | 251 | 29526495 |
Suicide attempt | 15.89 | 10.86 | 19 | 47762 | 34091 | 29492655 |
Burkholderia test positive | 15.74 | 10.86 | 13 | 47768 | 986 | 29525760 |
Angioedema | 15.71 | 10.86 | 17 | 47764 | 31898 | 29494848 |
Cytomegalovirus infection | 15.67 | 10.86 | 9 | 47772 | 23206 | 29503540 |
Nightmare | 15.41 | 10.86 | 47 | 47734 | 11370 | 29515376 |
Bone marrow failure | 15.41 | 10.86 | 13 | 47768 | 27436 | 29499310 |
Carditis | 15.29 | 10.86 | 6 | 47775 | 104 | 29526642 |
Hip surgery | 15.29 | 10.86 | 12 | 47769 | 846 | 29525900 |
Neoplasm progression | 15.19 | 10.86 | 65 | 47716 | 18547 | 29508199 |
Neurotoxicity | 15.13 | 10.86 | 55 | 47726 | 14558 | 29512188 |
Terminal insomnia | 15.11 | 10.86 | 9 | 47772 | 403 | 29526343 |
Paranasal sinus discomfort | 15.04 | 10.86 | 11 | 47770 | 697 | 29526049 |
Brief psychotic disorder with marked stressors | 14.95 | 10.86 | 7 | 47774 | 190 | 29526556 |
Device computer issue | 14.93 | 10.86 | 4 | 47777 | 18 | 29526728 |
Melaena | 14.92 | 10.86 | 17 | 47764 | 31159 | 29495587 |
Device failure | 14.35 | 10.86 | 17 | 47764 | 1999 | 29524747 |
Hypoglycaemia | 14.24 | 10.86 | 36 | 47745 | 48310 | 29478436 |
Epilepsy | 14.17 | 10.86 | 6 | 47775 | 18426 | 29508320 |
Blood pressure diastolic abnormal | 14.16 | 10.86 | 19 | 47762 | 2532 | 29524214 |
Device infusion issue | 14.13 | 10.86 | 10 | 47771 | 602 | 29526144 |
Cerebrovascular accident | 14.12 | 10.86 | 70 | 47711 | 76841 | 29449905 |
Peripheral swelling | 13.96 | 10.86 | 161 | 47620 | 63578 | 29463168 |
Postmortem blood drug level increased | 13.89 | 10.86 | 7 | 47774 | 224 | 29526522 |
Gastrointestinal tract irritation | 13.87 | 10.86 | 7 | 47774 | 225 | 29526521 |
Somnolence | 13.86 | 10.86 | 221 | 47560 | 93734 | 29433012 |
Dyspnoea paroxysmal nocturnal | 13.83 | 10.86 | 14 | 47767 | 1380 | 29525366 |
Odynophagia | 13.72 | 10.86 | 26 | 47755 | 4644 | 29522102 |
Failure to thrive | 13.70 | 10.86 | 35 | 47746 | 7649 | 29519097 |
Postmortem blood drug level | 13.61 | 10.86 | 6 | 47775 | 141 | 29526605 |
Bone infarction | 13.48 | 10.86 | 7 | 47774 | 239 | 29526507 |
Facial wasting | 13.46 | 10.86 | 6 | 47775 | 145 | 29526601 |
Oxygen saturation decreased | 13.43 | 10.86 | 121 | 47660 | 44816 | 29481930 |
Injection site mass | 13.18 | 10.86 | 28 | 47753 | 5427 | 29521319 |
Gastrointestinal haemorrhage | 13.15 | 10.86 | 75 | 47706 | 79458 | 29447288 |
Withdrawal hypertension | 13.02 | 10.86 | 6 | 47775 | 157 | 29526589 |
Administration related reaction | 13.00 | 10.86 | 5 | 47776 | 82 | 29526664 |
Osteomyelitis | 12.87 | 10.86 | 50 | 47731 | 13659 | 29513087 |
Anaemia of malignant disease | 12.85 | 10.86 | 8 | 47773 | 388 | 29526358 |
Intentional overdose | 12.71 | 10.86 | 27 | 47754 | 38501 | 29488245 |
Body temperature decreased | 12.66 | 10.86 | 42 | 47739 | 10622 | 29516124 |
Post-thoracotomy pain syndrome | 12.57 | 10.86 | 4 | 47777 | 36 | 29526710 |
Rib fracture | 12.44 | 10.86 | 47 | 47734 | 12671 | 29514075 |
Mucous stools | 12.36 | 10.86 | 12 | 47769 | 1125 | 29525621 |
Cerebral infarction | 12.31 | 10.86 | 13 | 47768 | 24662 | 29502084 |
Basal cell carcinoma | 12.23 | 10.86 | 6 | 47775 | 16904 | 29509842 |
Harlequin syndrome | 12.15 | 10.86 | 3 | 47778 | 9 | 29526737 |
Erythema | 12.12 | 10.86 | 72 | 47709 | 75534 | 29451212 |
Peripheral artery thrombosis | 12.08 | 10.86 | 16 | 47765 | 2106 | 29524640 |
Nephrolithiasis | 11.98 | 10.86 | 76 | 47705 | 25258 | 29501488 |
Ankylosing spondylitis | 11.96 | 10.86 | 23 | 47758 | 4153 | 29522593 |
Allodynia | 11.85 | 10.86 | 9 | 47772 | 604 | 29526142 |
Blood pressure systolic abnormal | 11.85 | 10.86 | 16 | 47765 | 2145 | 29524601 |
Aortic aneurysm | 11.79 | 10.86 | 29 | 47752 | 6191 | 29520555 |
Thymic cancer metastatic | 11.69 | 10.86 | 4 | 47777 | 46 | 29526700 |
Pseudopolyp | 11.50 | 10.86 | 6 | 47775 | 207 | 29526539 |
Palpitations | 11.48 | 10.86 | 22 | 47759 | 32582 | 29494164 |
Hepatitis | 11.47 | 10.86 | 10 | 47771 | 20773 | 29505973 |
Gastrointestinal scarring | 11.37 | 10.86 | 5 | 47776 | 117 | 29526629 |
Chylothorax | 11.35 | 10.86 | 9 | 47772 | 644 | 29526102 |
Drug use disorder | 11.25 | 10.86 | 20 | 47761 | 3402 | 29523344 |
Umbilical hernia | 11.23 | 10.86 | 21 | 47760 | 3714 | 29523032 |
Heart rate increased | 11.21 | 10.86 | 104 | 47677 | 38834 | 29487912 |
Toxicity to various agents | 11.14 | 10.86 | 363 | 47418 | 173298 | 29353448 |
Arrhythmia | 11.14 | 10.86 | 21 | 47760 | 31292 | 29495454 |
Blood albumin abnormal | 11.09 | 10.86 | 6 | 47775 | 223 | 29526523 |
Blood pressure increased | 11.03 | 10.86 | 174 | 47607 | 73629 | 29453117 |
Labelled drug-drug interaction medication error | 11.01 | 10.86 | 3 | 47778 | 12156 | 29514590 |
Diffuse large B-cell lymphoma recurrent | 10.98 | 10.86 | 17 | 47764 | 2580 | 29524166 |
Parkinsonian rest tremor | 10.95 | 10.86 | 5 | 47776 | 128 | 29526618 |
Type IIa hyperlipidaemia | 10.88 | 10.86 | 5 | 47776 | 130 | 29526616 |
MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
---|---|---|---|---|---|---|
Drug hypersensitivity | 342.08 | 9.99 | 1057 | 112543 | 236758 | 64148374 |
Temperature regulation disorder | 258.41 | 9.99 | 133 | 113467 | 4078 | 64381054 |
Drug withdrawal syndrome | 241.93 | 9.99 | 287 | 113313 | 31004 | 64354128 |
Constipation | 205.50 | 9.99 | 874 | 112726 | 228463 | 64156669 |
Drug dependence | 199.49 | 9.99 | 269 | 113331 | 33043 | 64352089 |
Food allergy | 193.38 | 9.99 | 138 | 113462 | 7713 | 64377419 |
Coeliac disease | 188.84 | 9.99 | 133 | 113467 | 7279 | 64377853 |
Hyperaesthesia | 178.18 | 9.99 | 145 | 113455 | 9869 | 64375263 |
Nausea | 167.01 | 9.99 | 2112 | 111488 | 783688 | 63601444 |
Pain | 165.84 | 9.99 | 1593 | 112007 | 551918 | 63833214 |
Immunodeficiency | 138.22 | 9.99 | 156 | 113444 | 15968 | 64369164 |
Appendicolith | 131.90 | 9.99 | 80 | 113520 | 3389 | 64381743 |
Bursitis | 124.83 | 9.99 | 171 | 113429 | 21314 | 64363818 |
Drug interaction | 122.12 | 9.99 | 287 | 113313 | 361796 | 64023336 |
Rheumatoid arthritis | 120.81 | 9.99 | 591 | 113009 | 163703 | 64221429 |
Back pain | 118.33 | 9.99 | 800 | 112800 | 249371 | 64135761 |
Respiratory depression | 117.66 | 9.99 | 174 | 113426 | 23269 | 64361863 |
Vomiting | 107.72 | 9.99 | 1460 | 112140 | 549657 | 63835475 |
Somnolence | 100.95 | 9.99 | 659 | 112941 | 202986 | 64182146 |
Sedation | 89.20 | 9.99 | 214 | 113386 | 41248 | 64343884 |
Medical device site pain | 87.63 | 9.99 | 28 | 113572 | 232 | 64384900 |
Pneumonia viral | 87.14 | 9.99 | 87 | 113513 | 7735 | 64377397 |
Delirium | 81.67 | 9.99 | 288 | 113312 | 68906 | 64316226 |
Ankylosing spondylitis | 78.07 | 9.99 | 84 | 113516 | 8150 | 64376982 |
Unresponsive to stimuli | 77.85 | 9.99 | 230 | 113370 | 50163 | 64334969 |
Respiratory rate decreased | 77.73 | 9.99 | 64 | 113536 | 4427 | 64380705 |
Hyperhidrosis | 71.74 | 9.99 | 420 | 113180 | 124500 | 64260632 |
Toxicologic test abnormal | 70.32 | 9.99 | 37 | 113563 | 1188 | 64383944 |
Abdominal pain | 68.58 | 9.99 | 846 | 112754 | 311529 | 64073603 |
Interstitial lung disease | 68.19 | 9.99 | 44 | 113556 | 97688 | 64287444 |
Soft tissue disorder | 68.11 | 9.99 | 52 | 113548 | 3224 | 64381908 |
Myocardial infarction | 65.45 | 9.99 | 120 | 113480 | 165701 | 64219431 |
Inadequate analgesia | 65.35 | 9.99 | 55 | 113545 | 3923 | 64381209 |
Pneumonia aspiration | 64.27 | 9.99 | 240 | 113360 | 59031 | 64326101 |
Arthritis | 61.18 | 9.99 | 301 | 113299 | 83513 | 64301619 |
Victim of child abuse | 60.74 | 9.99 | 30 | 113570 | 841 | 64384291 |
Extremity contracture | 60.56 | 9.99 | 37 | 113563 | 1588 | 64383544 |
Joint dislocation | 60.28 | 9.99 | 87 | 113513 | 11378 | 64373754 |
Acute kidney injury | 58.94 | 9.99 | 507 | 113093 | 448733 | 63936399 |
Drug tolerance | 57.56 | 9.99 | 62 | 113538 | 6023 | 64379109 |
Exostosis | 57.54 | 9.99 | 85 | 113515 | 11353 | 64373779 |
Neutropenia | 56.96 | 9.99 | 223 | 113377 | 239401 | 64145731 |
Malignant neoplasm progression | 55.70 | 9.99 | 365 | 113235 | 112506 | 64272626 |
Neoplasm progression | 54.94 | 9.99 | 178 | 113422 | 40786 | 64344346 |
Drug reaction with eosinophilia and systemic symptoms | 54.64 | 9.99 | 14 | 113586 | 54203 | 64330929 |
Appendicitis | 54.59 | 9.99 | 91 | 113509 | 13478 | 64371654 |
Intentional overdose | 54.36 | 9.99 | 47 | 113553 | 89897 | 64295235 |
Cardiac failure congestive | 53.78 | 9.99 | 92 | 113508 | 130488 | 64254644 |
Hypermobility syndrome | 52.06 | 9.99 | 23 | 113577 | 497 | 64384635 |
Sickle cell anaemia with crisis | 51.62 | 9.99 | 55 | 113545 | 5277 | 64379855 |
Cardiac failure | 51.16 | 9.99 | 97 | 113503 | 132276 | 64252856 |
Postmortem blood drug level abnormal | 50.28 | 9.99 | 24 | 113576 | 623 | 64384509 |
Hepatic function abnormal | 47.59 | 9.99 | 27 | 113573 | 64286 | 64320846 |
Lower respiratory tract infection | 47.48 | 9.99 | 58 | 113542 | 94556 | 64290576 |
Mental status changes | 47.04 | 9.99 | 223 | 113377 | 60939 | 64324193 |
Postoperative ileus | 46.22 | 9.99 | 26 | 113574 | 955 | 64384177 |
Duodenal ulcer perforation | 46.10 | 9.99 | 4 | 113596 | 34621 | 64350511 |
Gastrooesophageal reflux disease | 46.08 | 9.99 | 277 | 113323 | 82866 | 64302266 |
Orthostatic hypotension | 45.35 | 9.99 | 13 | 113587 | 46725 | 64338407 |
Narcotic bowel syndrome | 45.29 | 9.99 | 17 | 113583 | 237 | 64384895 |
Drug diversion | 45.27 | 9.99 | 27 | 113573 | 1109 | 64384023 |
Renal impairment | 44.63 | 9.99 | 108 | 113492 | 134909 | 64250223 |
Breast cancer metastatic | 44.60 | 9.99 | 59 | 113541 | 7110 | 64378022 |
Stress | 44.60 | 9.99 | 218 | 113382 | 60316 | 64324816 |
Drug abuse | 44.42 | 9.99 | 391 | 113209 | 131983 | 64253149 |
Lactic acidosis | 43.72 | 9.99 | 27 | 113573 | 61383 | 64323749 |
Helicobacter infection | 42.51 | 9.99 | 8 | 113592 | 38354 | 64346778 |
General physical health deterioration | 41.96 | 9.99 | 547 | 113053 | 203878 | 64181254 |
Hepatocellular injury | 41.35 | 9.99 | 14 | 113586 | 45221 | 64339911 |
Postmortem blood drug level increased | 40.90 | 9.99 | 22 | 113578 | 739 | 64384393 |
Small intestinal obstruction | 40.69 | 9.99 | 112 | 113488 | 23461 | 64361671 |
Alopecia | 40.12 | 9.99 | 153 | 113447 | 165537 | 64219595 |
Blood pressure systolic increased | 40.01 | 9.99 | 183 | 113417 | 49270 | 64335862 |
Bradycardia | 39.52 | 9.99 | 94 | 113506 | 118125 | 64267007 |
Injection site erythema | 39.25 | 9.99 | 40 | 113560 | 70760 | 64314372 |
Retinitis | 38.80 | 9.99 | 31 | 113569 | 2054 | 64383078 |
Implant site extravasation | 38.52 | 9.99 | 21 | 113579 | 725 | 64384407 |
Plasma cell myeloma | 38.39 | 9.99 | 172 | 113428 | 45903 | 64339229 |
Opiates positive | 37.50 | 9.99 | 22 | 113578 | 876 | 64384256 |
Drug resistance | 37.48 | 9.99 | 8 | 113592 | 35094 | 64350038 |
Hepatitis | 36.91 | 9.99 | 17 | 113583 | 45565 | 64339567 |
Poor venous access | 36.87 | 9.99 | 73 | 113527 | 12344 | 64372788 |
Scar | 36.50 | 9.99 | 76 | 113524 | 13322 | 64371810 |
Foreign body embolism | 36.28 | 9.99 | 8 | 113592 | 10 | 64385122 |
Anaesthetic complication neurological | 35.73 | 9.99 | 18 | 113582 | 527 | 64384605 |
Syncope | 34.74 | 9.99 | 151 | 113449 | 157484 | 64227648 |
Product dose omission issue | 34.67 | 9.99 | 201 | 113399 | 194546 | 64190586 |
Bone erosion | 34.23 | 9.99 | 68 | 113532 | 11527 | 64373605 |
Injection site pruritus | 34.07 | 9.99 | 12 | 113588 | 37814 | 64347318 |
Therapeutic product effect incomplete | 33.85 | 9.99 | 304 | 113296 | 103178 | 64281954 |
Osteoporosis | 33.51 | 9.99 | 155 | 113445 | 41925 | 64343207 |
Hepatic cirrhosis | 33.23 | 9.99 | 112 | 113488 | 26186 | 64358946 |
Foot deformity | 33.16 | 9.99 | 83 | 113517 | 16421 | 64368711 |
Cytomegalovirus infection | 33.16 | 9.99 | 12 | 113588 | 37187 | 64347945 |
Eosinophilia | 32.75 | 9.99 | 13 | 113587 | 38063 | 64347069 |
Device related thrombosis | 32.55 | 9.99 | 28 | 113572 | 2057 | 64383075 |
Synovitis | 31.85 | 9.99 | 290 | 113310 | 98800 | 64286332 |
Electrocardiogram QT prolonged | 31.77 | 9.99 | 57 | 113543 | 79391 | 64305741 |
Coronary artery disease | 31.44 | 9.99 | 36 | 113564 | 60397 | 64324735 |
Rhabdomyolysis | 31.40 | 9.99 | 72 | 113528 | 91654 | 64293478 |
Injection site swelling | 31.11 | 9.99 | 17 | 113583 | 41336 | 64343796 |
Device failure | 31.11 | 9.99 | 44 | 113556 | 5648 | 64379484 |
Gastrointestinal haemorrhage | 30.86 | 9.99 | 124 | 113476 | 132188 | 64252944 |
Overwork | 30.82 | 9.99 | 9 | 113591 | 53 | 64385079 |
Chest injury | 30.74 | 9.99 | 29 | 113571 | 2404 | 64382728 |
Drug tolerance increased | 30.74 | 9.99 | 17 | 113583 | 604 | 64384528 |
Infusion site mass | 30.71 | 9.99 | 20 | 113580 | 961 | 64384171 |
Asthma | 30.26 | 9.99 | 278 | 113322 | 94947 | 64290185 |
Rash erythematous | 30.18 | 9.99 | 167 | 113433 | 48466 | 64336666 |
Fluid retention | 30.15 | 9.99 | 194 | 113406 | 59412 | 64325720 |
Pustular psoriasis | 30.08 | 9.99 | 37 | 113563 | 4146 | 64380986 |
Neuralgia | 30.04 | 9.99 | 108 | 113492 | 26076 | 64359056 |
Agranulocytosis | 29.82 | 9.99 | 15 | 113585 | 38214 | 64346918 |
Acute chest syndrome | 29.47 | 9.99 | 19 | 113581 | 897 | 64384235 |
Myoclonus | 29.15 | 9.99 | 104 | 113496 | 25014 | 64360118 |
Arachnoiditis | 29.09 | 9.99 | 17 | 113583 | 672 | 64384460 |
Bone marrow failure | 29.04 | 9.99 | 25 | 113575 | 47927 | 64337205 |
Respiratory arrest | 29.01 | 9.99 | 176 | 113424 | 52809 | 64332323 |
Angioedema | 28.85 | 9.99 | 40 | 113560 | 61781 | 64323351 |
Xyphoid retraction | 28.76 | 9.99 | 11 | 113589 | 162 | 64384970 |
Death | 28.34 | 9.99 | 1078 | 112522 | 481627 | 63903505 |
Muscle injury | 28.28 | 9.99 | 6 | 113594 | 26431 | 64358701 |
Overdose | 28.27 | 9.99 | 416 | 113184 | 159150 | 64225982 |
Apnoea | 28.25 | 9.99 | 59 | 113541 | 10363 | 64374769 |
Glossodynia | 28.10 | 9.99 | 44 | 113556 | 64652 | 64320480 |
Red cell distribution width increased | 28.06 | 9.99 | 65 | 113535 | 12244 | 64372888 |
Rash | 28.04 | 9.99 | 605 | 112995 | 457944 | 63927188 |
Sleep disorder due to general medical condition, insomnia type | 28.02 | 9.99 | 6 | 113594 | 26264 | 64358868 |
Oral pain | 27.88 | 9.99 | 109 | 113491 | 27384 | 64357748 |
Rhesus antigen positive | 27.70 | 9.99 | 10 | 113590 | 124 | 64385008 |
Cholestasis | 27.66 | 9.99 | 23 | 113577 | 44849 | 64340283 |
Pemphigus | 27.61 | 9.99 | 40 | 113560 | 60661 | 64324471 |
Suicide attempt | 27.45 | 9.99 | 52 | 113548 | 70955 | 64314177 |
Hereditary angioedema | 27.42 | 9.99 | 34 | 113566 | 3842 | 64381290 |
Procedural pain | 27.08 | 9.99 | 74 | 113526 | 15434 | 64369698 |
Maternal exposure during pregnancy | 26.95 | 9.99 | 83 | 113517 | 95801 | 64289331 |
Melaena | 26.68 | 9.99 | 33 | 113567 | 53515 | 64331617 |
Platelet aggregation inhibition | 26.54 | 9.99 | 10 | 113590 | 141 | 64384991 |
Abdominal distension | 26.45 | 9.99 | 272 | 113328 | 95722 | 64289410 |
Treatment failure | 26.29 | 9.99 | 111 | 113489 | 116705 | 64268427 |
Alanine aminotransferase increased | 26.09 | 9.99 | 141 | 113459 | 138890 | 64246242 |
Herpes zoster | 26.08 | 9.99 | 233 | 113367 | 78954 | 64306178 |
Cerebral haemorrhage | 25.96 | 9.99 | 31 | 113569 | 51059 | 64334073 |
Substance dependence | 25.87 | 9.99 | 14 | 113586 | 476 | 64384656 |
Epidural lipomatosis | 25.32 | 9.99 | 17 | 113583 | 860 | 64384272 |
Acute myocardial infarction | 25.28 | 9.99 | 53 | 113547 | 69665 | 64315467 |
Cerebrovascular accident | 25.01 | 9.99 | 141 | 113459 | 137442 | 64247690 |
Hypertensive encephalopathy | 24.92 | 9.99 | 17 | 113583 | 883 | 64384249 |
Systemic lupus erythematosus | 24.92 | 9.99 | 63 | 113537 | 77549 | 64307583 |
Metastases to bone | 24.91 | 9.99 | 86 | 113514 | 20349 | 64364783 |
Amputation stump pain | 24.76 | 9.99 | 7 | 113593 | 36 | 64385096 |
Folliculitis | 24.69 | 9.99 | 11 | 113589 | 30066 | 64355066 |
Blood pressure fluctuation | 24.52 | 9.99 | 166 | 113434 | 51705 | 64333427 |
Device power source issue | 24.40 | 9.99 | 16 | 113584 | 778 | 64384354 |
Blood pressure increased | 24.27 | 9.99 | 433 | 113167 | 172119 | 64213013 |
Incorrect route of product administration | 24.14 | 9.99 | 93 | 113507 | 23205 | 64361927 |
Extrapyramidal disorder | 24.12 | 9.99 | 3 | 113597 | 19549 | 64365583 |
Alveolitis | 23.92 | 9.99 | 31 | 113569 | 3661 | 64381471 |
Apnoeic attack | 23.87 | 9.99 | 14 | 113586 | 557 | 64384575 |
Hypoaesthesia | 23.60 | 9.99 | 360 | 113240 | 138748 | 64246384 |
Migraine | 23.59 | 9.99 | 190 | 113410 | 62487 | 64322645 |
Blood immunoglobulin M decreased | 23.55 | 9.99 | 17 | 113583 | 967 | 64384165 |
Prostate cancer metastatic | 23.40 | 9.99 | 29 | 113571 | 3275 | 64381857 |
Heart rate increased | 23.23 | 9.99 | 271 | 113329 | 98404 | 64286728 |
Systemic infection | 23.02 | 9.99 | 33 | 113567 | 4288 | 64380844 |
Status epilepticus | 23.00 | 9.99 | 5 | 113595 | 21658 | 64363474 |
Child abuse | 22.90 | 9.99 | 10 | 113590 | 210 | 64384922 |
Blister | 22.82 | 9.99 | 70 | 113530 | 80897 | 64304235 |
Exposure during pregnancy | 22.72 | 9.99 | 66 | 113534 | 77609 | 64307523 |
Head banging | 22.59 | 9.99 | 13 | 113587 | 499 | 64384633 |
Device infusion issue | 22.30 | 9.99 | 21 | 113579 | 1737 | 64383395 |
Osteoarthritis | 22.23 | 9.99 | 189 | 113411 | 63147 | 64321985 |
Anti-cyclic citrullinated peptide antibody positive | 22.20 | 9.99 | 33 | 113567 | 49529 | 64335603 |
Hyperkalaemia | 22.20 | 9.99 | 97 | 113503 | 101032 | 64284100 |
Hypoxia | 22.06 | 9.99 | 245 | 113355 | 87904 | 64297228 |
Inappropriate antidiuretic hormone secretion | 21.99 | 9.99 | 6 | 113594 | 22283 | 64362849 |
Rheumatoid factor negative | 21.96 | 9.99 | 17 | 113583 | 1076 | 64384056 |
Neurotoxicity | 21.86 | 9.99 | 101 | 113499 | 27303 | 64357829 |
Rib fracture | 21.75 | 9.99 | 92 | 113508 | 23946 | 64361186 |
Drug eruption | 21.69 | 9.99 | 19 | 113581 | 36117 | 64349015 |
Allodynia | 21.61 | 9.99 | 18 | 113582 | 1265 | 64383867 |
Blepharospasm | 21.34 | 9.99 | 28 | 113572 | 3347 | 64381785 |
Pneumocystis jirovecii pneumonia | 21.32 | 9.99 | 11 | 113589 | 27623 | 64357509 |
Immune-mediated hepatitis | 21.19 | 9.99 | 24 | 113576 | 2465 | 64382667 |
Fatigue | 20.93 | 9.99 | 1559 | 112041 | 747171 | 63637961 |
Tissue infiltration | 20.82 | 9.99 | 13 | 113587 | 580 | 64384552 |
Compartment syndrome | 20.64 | 9.99 | 31 | 113569 | 4201 | 64380931 |
Serotonin syndrome | 20.57 | 9.99 | 129 | 113471 | 39153 | 64345979 |
Photophobia | 20.41 | 9.99 | 72 | 113528 | 17221 | 64367911 |
Ligament pain | 20.39 | 9.99 | 9 | 113591 | 194 | 64384938 |
Transient ischaemic attack | 20.20 | 9.99 | 29 | 113571 | 44153 | 64340979 |
Drug intolerance | 20.17 | 9.99 | 453 | 113147 | 187539 | 64197593 |
Spinal cord compression | 20.00 | 9.99 | 36 | 113564 | 5667 | 64379465 |
Coma | 19.90 | 9.99 | 239 | 113361 | 87376 | 64297756 |
Hypoglycaemia | 19.86 | 9.99 | 86 | 113514 | 89806 | 64295326 |
Progressive multifocal leukoencephalopathy | 19.78 | 9.99 | 4 | 113596 | 18228 | 64366904 |
Basal ganglion degeneration | 19.73 | 9.99 | 11 | 113589 | 397 | 64384735 |
Irritable bowel syndrome | 19.72 | 9.99 | 22 | 113578 | 37347 | 64347785 |
Cerebral infarction | 19.71 | 9.99 | 26 | 113574 | 41018 | 64344114 |
Ascites | 19.68 | 9.99 | 181 | 113419 | 61820 | 64323312 |
Aspartate aminotransferase increased | 19.55 | 9.99 | 127 | 113473 | 119661 | 64265471 |
Abortion spontaneous | 19.41 | 9.99 | 10 | 113590 | 25133 | 64359999 |
Visual acuity reduced | 19.22 | 9.99 | 12 | 113588 | 27129 | 64358003 |
Anaemia of malignant disease | 19.16 | 9.99 | 13 | 113587 | 669 | 64384463 |
Myelosuppression | 19.12 | 9.99 | 9 | 113591 | 23821 | 64361311 |
Radiation necrosis | 18.98 | 9.99 | 10 | 113590 | 322 | 64384810 |
Forced expiratory flow decreased | 18.95 | 9.99 | 9 | 113591 | 231 | 64384901 |
Painful respiration | 18.62 | 9.99 | 25 | 113575 | 3056 | 64382076 |
Malignant polyp | 18.58 | 9.99 | 8 | 113592 | 162 | 64384970 |
Rash maculo-papular | 18.56 | 9.99 | 34 | 113566 | 46992 | 64338140 |
Pancreatitis | 18.42 | 9.99 | 173 | 113427 | 59434 | 64325698 |
Eye operation | 18.37 | 9.99 | 19 | 113581 | 1761 | 64383371 |
Pericarditis | 18.37 | 9.99 | 53 | 113547 | 62463 | 64322669 |
Anxiety | 18.32 | 9.99 | 477 | 113123 | 202172 | 64182960 |
Pregnancy | 18.15 | 9.99 | 7 | 113593 | 20858 | 64364274 |
Rash pruritic | 18.12 | 9.99 | 47 | 113553 | 57357 | 64327775 |
Renal failure | 17.99 | 9.99 | 219 | 113381 | 181469 | 64203663 |
Substance abuse | 17.91 | 9.99 | 46 | 113554 | 9246 | 64375886 |
Hand deformity | 17.88 | 9.99 | 54 | 113546 | 62717 | 64322415 |
Intentional self-injury | 17.76 | 9.99 | 15 | 113585 | 29029 | 64356103 |
Seizure like phenomena | 17.71 | 9.99 | 18 | 113582 | 1634 | 64383498 |
Inappropriate schedule of product administration | 17.69 | 9.99 | 244 | 113356 | 92042 | 64293090 |
Blood creatine phosphokinase increased | 17.68 | 9.99 | 49 | 113551 | 58509 | 64326623 |
Basal cell carcinoma | 17.57 | 9.99 | 17 | 113583 | 30821 | 64354311 |
Walking aid user | 17.54 | 9.99 | 36 | 113564 | 6245 | 64378887 |
Limb mass | 17.48 | 9.99 | 24 | 113576 | 2997 | 64382135 |
Screaming | 17.42 | 9.99 | 26 | 113574 | 3503 | 64381629 |
Nervousness | 17.35 | 9.99 | 100 | 113500 | 29456 | 64355676 |
Sopor | 17.31 | 9.99 | 16 | 113584 | 29645 | 64355487 |
Fibromyalgia | 17.28 | 9.99 | 115 | 113485 | 35616 | 64349516 |
Drug use disorder | 17.27 | 9.99 | 35 | 113565 | 6019 | 64379113 |
Respiratory syncytial virus infection | 17.25 | 9.99 | 39 | 113561 | 7229 | 64377903 |
Diabetes mellitus inadequate control | 17.19 | 9.99 | 8 | 113592 | 21313 | 64363819 |
Umbilical hernia | 17.00 | 9.99 | 29 | 113571 | 4376 | 64380756 |
International normalised ratio increased | 16.73 | 9.99 | 77 | 113523 | 79090 | 64306042 |
Hypothermia | 16.72 | 9.99 | 7 | 113593 | 19849 | 64365283 |
Cardiogenic shock | 16.68 | 9.99 | 106 | 113494 | 32321 | 64352811 |
Spinal shock | 16.64 | 9.99 | 5 | 113595 | 33 | 64385099 |
Liver disorder | 16.59 | 9.99 | 44 | 113556 | 53307 | 64331825 |
Failure to thrive | 16.55 | 9.99 | 48 | 113552 | 10356 | 64374776 |
Tubulointerstitial nephritis | 16.52 | 9.99 | 18 | 113582 | 30891 | 64354241 |
Device computer issue | 16.51 | 9.99 | 5 | 113595 | 34 | 64385098 |
Palpitations | 16.43 | 9.99 | 112 | 113488 | 104376 | 64280756 |
Therapeutic response decreased | 16.39 | 9.99 | 152 | 113448 | 52036 | 64333096 |
Accidental overdose | 16.22 | 9.99 | 108 | 113492 | 33449 | 64351683 |
Ocular procedural complication | 15.96 | 9.99 | 10 | 113590 | 449 | 64384683 |
Swollen tongue | 15.93 | 9.99 | 23 | 113577 | 34931 | 64350201 |
Antasthmatic drug level | 15.80 | 9.99 | 5 | 113595 | 40 | 64385092 |
Post procedural complication | 15.79 | 9.99 | 77 | 113523 | 21276 | 64363856 |
Hyperthermia | 15.70 | 9.99 | 4 | 113596 | 15546 | 64369586 |
Septic shock | 15.62 | 9.99 | 115 | 113485 | 105322 | 64279810 |
Lethargy | 15.61 | 9.99 | 196 | 113404 | 72398 | 64312734 |
Adverse drug reaction | 15.60 | 9.99 | 135 | 113465 | 45329 | 64339803 |
Osteonecrosis of jaw | 15.54 | 9.99 | 29 | 113571 | 39796 | 64345336 |
Thrombocytopenia | 15.53 | 9.99 | 289 | 113311 | 223512 | 64161620 |
Tenderness | 15.45 | 9.99 | 72 | 113528 | 19530 | 64365602 |
Ischaemic stroke | 15.42 | 9.99 | 17 | 113583 | 29018 | 64356114 |
Body temperature decreased | 15.40 | 9.99 | 88 | 113512 | 25840 | 64359292 |
Lupus-like syndrome | 15.40 | 9.99 | 42 | 113558 | 8749 | 64376383 |
Analgesic drug level | 15.38 | 9.99 | 5 | 113595 | 44 | 64385088 |
Uterine enlargement | 15.37 | 9.99 | 12 | 113588 | 769 | 64384363 |
Injection site pain | 15.33 | 9.99 | 124 | 113476 | 111284 | 64273848 |
Biliary tract infection | 15.32 | 9.99 | 13 | 113587 | 938 | 64384194 |
Labelled drug-drug interaction medication error | 15.29 | 9.99 | 10 | 113590 | 22052 | 64363080 |
Colorectal cancer metastatic | 15.21 | 9.99 | 13 | 113587 | 947 | 64384185 |
Microembolism | 15.19 | 9.99 | 5 | 113595 | 46 | 64385086 |
Urticaria | 15.18 | 9.99 | 176 | 113424 | 147141 | 64237991 |
Monoplegia | 15.08 | 9.99 | 24 | 113576 | 3419 | 64381713 |
Sinus bradycardia | 15.04 | 9.99 | 11 | 113589 | 22882 | 64362250 |
Hypopnoea | 15.02 | 9.99 | 23 | 113577 | 3171 | 64381961 |
Red blood cell sedimentation rate abnormal | 14.98 | 9.99 | 5 | 113595 | 16301 | 64368831 |
Neck pain | 14.93 | 9.99 | 170 | 113430 | 61363 | 64323769 |
Adiposis dolorosa | 14.81 | 9.99 | 8 | 113592 | 271 | 64384861 |
Hepatotoxicity | 14.81 | 9.99 | 30 | 113570 | 39932 | 64345200 |
Arthritis infective | 14.81 | 9.99 | 36 | 113564 | 6994 | 64378138 |
Obstruction | 14.73 | 9.99 | 23 | 113577 | 3225 | 64381907 |
Peripheral swelling | 14.69 | 9.99 | 477 | 113123 | 208676 | 64176456 |
Eye disorder | 14.65 | 9.99 | 69 | 113531 | 18800 | 64366332 |
Mitral valve incompetence | 14.64 | 9.99 | 14 | 113586 | 25524 | 64359608 |
Vitamin K deficiency | 14.61 | 9.99 | 11 | 113589 | 668 | 64384464 |
COVID-19 | 14.58 | 9.99 | 62 | 113538 | 65078 | 64320054 |
Exposure to toxic agent | 14.56 | 9.99 | 33 | 113567 | 6126 | 64379006 |
Ileus | 14.34 | 9.99 | 79 | 113521 | 22887 | 64362245 |
Tricuspid valve incompetence | 14.30 | 9.99 | 6 | 113594 | 16997 | 64368135 |
Oesophageal infection | 14.26 | 9.99 | 10 | 113590 | 543 | 64384589 |
Pelvic pain | 14.26 | 9.99 | 47 | 113553 | 10863 | 64374269 |
Anaesthesia | 14.25 | 9.99 | 9 | 113591 | 410 | 64384722 |
Miliaria | 14.21 | 9.99 | 14 | 113586 | 1224 | 64383908 |
Intestinal obstruction | 14.20 | 9.99 | 111 | 113489 | 36175 | 64348957 |
Psychomotor hyperactivity | 14.05 | 9.99 | 4 | 113596 | 14447 | 64370685 |
Musculoskeletal pain | 14.02 | 9.99 | 211 | 113389 | 81083 | 64304049 |
Silicon granuloma | 13.96 | 9.99 | 3 | 113597 | 3 | 64385129 |
Odynophagia | 13.94 | 9.99 | 43 | 113557 | 9598 | 64375534 |
Tuberculosis | 13.86 | 9.99 | 3 | 113597 | 13035 | 64372097 |
Cough | 13.78 | 9.99 | 416 | 113184 | 301732 | 64083400 |
Tumour pain | 13.74 | 9.99 | 17 | 113583 | 1916 | 64383216 |
Heart rate irregular | 13.72 | 9.99 | 89 | 113511 | 27324 | 64357808 |
Blood glucose increased | 13.57 | 9.99 | 109 | 113491 | 97964 | 64287168 |
Cholangitis infective | 13.50 | 9.99 | 9 | 113591 | 450 | 64384682 |
Delirium tremens | 13.38 | 9.99 | 10 | 113590 | 600 | 64384532 |
Stevens-Johnson syndrome | 13.31 | 9.99 | 25 | 113575 | 34224 | 64350908 |
Pulmonary fibrosis | 13.28 | 9.99 | 20 | 113580 | 29858 | 64355274 |
Drug ineffective | 13.26 | 9.99 | 1681 | 111919 | 838566 | 63546566 |
Lymphoedema | 13.24 | 9.99 | 43 | 113557 | 9862 | 64375270 |
Blood loss anaemia | 13.23 | 9.99 | 4 | 113596 | 13888 | 64371244 |
Pathogen resistance | 13.10 | 9.99 | 3 | 113597 | 12540 | 64372592 |
Needle issue | 13.08 | 9.99 | 41 | 113559 | 9231 | 64375901 |
Groin pain | 13.07 | 9.99 | 47 | 113553 | 11346 | 64373786 |
Myocardial ischaemia | 13.04 | 9.99 | 13 | 113587 | 23238 | 64361894 |
Sinusitis | 12.93 | 9.99 | 180 | 113420 | 145748 | 64239384 |
Reading disorder | 12.86 | 9.99 | 11 | 113589 | 802 | 64384330 |
Withdrawal syndrome | 12.84 | 9.99 | 78 | 113522 | 23414 | 64361718 |
Product prescribing error | 12.77 | 9.99 | 106 | 113494 | 35163 | 64349969 |
Abdominal tenderness | 12.73 | 9.99 | 41 | 113559 | 9364 | 64375768 |
Blood pressure diastolic abnormal | 12.70 | 9.99 | 48 | 113552 | 11869 | 64373263 |
Abdominal pain lower | 12.68 | 9.99 | 85 | 113515 | 26384 | 64358748 |
Anuria | 12.60 | 9.99 | 9 | 113591 | 18955 | 64366177 |
Implant site haematoma | 12.56 | 9.99 | 6 | 113594 | 156 | 64384976 |
Blood urea increased | 12.56 | 9.99 | 38 | 113562 | 44115 | 64341017 |
Product substitution issue | 12.51 | 9.99 | 8 | 113592 | 17853 | 64367279 |
Abdominal discomfort | 12.47 | 9.99 | 236 | 113364 | 182086 | 64203046 |
Ventricular tachycardia | 12.46 | 9.99 | 26 | 113574 | 34239 | 64350893 |
Oxygen saturation decreased | 12.36 | 9.99 | 261 | 113339 | 106915 | 64278217 |
Brief psychotic disorder with marked stressors | 12.28 | 9.99 | 7 | 113593 | 264 | 64384868 |
Cystitis | 12.27 | 9.99 | 122 | 113478 | 42553 | 64342579 |
Weight decreased | 12.24 | 9.99 | 618 | 112982 | 285121 | 64100011 |
Extradural haematoma | 12.20 | 9.99 | 19 | 113581 | 2657 | 64382475 |
Respiratory rate increased | 12.08 | 9.99 | 64 | 113536 | 18267 | 64366865 |
Pain in extremity | 12.07 | 9.99 | 651 | 112949 | 302434 | 64082698 |
Hypercholesterolaemia | 12.04 | 9.99 | 6 | 113594 | 15367 | 64369765 |
Injection site reaction | 12.00 | 9.99 | 42 | 113558 | 46622 | 64338510 |
Altered state of consciousness | 11.98 | 9.99 | 31 | 113569 | 37871 | 64347261 |
Cardiac failure acute | 11.89 | 9.99 | 7 | 113593 | 16337 | 64368795 |
Bone pain | 11.79 | 9.99 | 132 | 113468 | 47440 | 64337692 |
Spinal laminectomy | 11.77 | 9.99 | 9 | 113591 | 559 | 64384573 |
Haematotoxicity | 11.77 | 9.99 | 4 | 113596 | 12892 | 64372240 |
Taste disorder | 11.76 | 9.99 | 40 | 113560 | 9393 | 64375739 |
Gastrointestinal mucosa hyperaemia | 11.72 | 9.99 | 8 | 113592 | 416 | 64384716 |
Swelling face | 11.66 | 9.99 | 59 | 113541 | 59107 | 64326025 |
Burkholderia test positive | 11.62 | 9.99 | 9 | 113591 | 570 | 64384562 |
Gallbladder disorder | 11.60 | 9.99 | 60 | 113540 | 16970 | 64368162 |
Arthropathy | 11.52 | 9.99 | 147 | 113453 | 120820 | 64264312 |
Haematuria | 11.52 | 9.99 | 61 | 113539 | 60410 | 64324722 |
Type IIa hyperlipidaemia | 11.48 | 9.99 | 6 | 113594 | 190 | 64384942 |
Infusion site granuloma | 11.43 | 9.99 | 3 | 113597 | 11 | 64385121 |
Joint stiffness | 11.35 | 9.99 | 92 | 113508 | 30312 | 64354820 |
Sepsis | 11.31 | 9.99 | 505 | 113095 | 229836 | 64155296 |
Feeding disorder | 11.28 | 9.99 | 49 | 113551 | 12900 | 64372232 |
Caesarean section | 11.19 | 9.99 | 3 | 113597 | 11271 | 64373861 |
Accidental death | 11.18 | 9.99 | 22 | 113578 | 3703 | 64381429 |
Respiratory tract inflammation | 11.11 | 9.99 | 10 | 113590 | 780 | 64384352 |
Ejection fraction decreased | 11.11 | 9.99 | 21 | 113579 | 28686 | 64356446 |
Weight fluctuation | 11.11 | 9.99 | 36 | 113564 | 8246 | 64376886 |
Defaecation disorder | 11.08 | 9.99 | 8 | 113592 | 455 | 64384677 |
Withdrawal hypertension | 11.06 | 9.99 | 7 | 113593 | 320 | 64384812 |
Atelectasis | 11.00 | 9.99 | 84 | 113516 | 27182 | 64357950 |
Foreign body reaction | 10.99 | 9.99 | 5 | 113595 | 116 | 64385016 |
Anaphylactic reaction | 10.99 | 9.99 | 176 | 113424 | 68488 | 64316644 |
Pulmonary hypertension | 10.98 | 9.99 | 39 | 113561 | 43100 | 64342032 |
Impaired healing | 10.97 | 9.99 | 62 | 113538 | 60411 | 64324721 |
Mental disorder | 10.96 | 9.99 | 82 | 113518 | 26363 | 64358769 |
Metastases to liver | 10.94 | 9.99 | 76 | 113524 | 23865 | 64361267 |
Pancytopenia | 10.91 | 9.99 | 182 | 113418 | 143127 | 64242005 |
Mucosal inflammation | 10.91 | 9.99 | 65 | 113535 | 62519 | 64322613 |
Umbilical discharge | 10.83 | 9.99 | 5 | 113595 | 120 | 64385012 |
Incision site swelling | 10.80 | 9.99 | 5 | 113595 | 121 | 64385011 |
Gastric infection | 10.76 | 9.99 | 20 | 113580 | 3228 | 64381904 |
Bladder cancer | 10.74 | 9.99 | 3 | 113597 | 10971 | 64374161 |
Cholangitis sclerosing | 10.73 | 9.99 | 15 | 113585 | 1904 | 64383228 |
Angina unstable | 10.73 | 9.99 | 7 | 113593 | 15460 | 64369672 |
Product storage error | 10.73 | 9.99 | 5 | 113595 | 13313 | 64371819 |
Vein collapse | 10.72 | 9.99 | 9 | 113591 | 640 | 64384492 |
Coccygectomy | 10.68 | 9.99 | 3 | 113597 | 15 | 64385117 |
Salivary hypersecretion | 10.64 | 9.99 | 4 | 113596 | 12109 | 64373023 |
Device kink | 10.63 | 9.99 | 14 | 113586 | 1679 | 64383453 |
Lymphopenia | 10.62 | 9.99 | 18 | 113582 | 25639 | 64359493 |
Administration related reaction | 10.61 | 9.99 | 5 | 113595 | 126 | 64385006 |
Aspergillus infection | 10.59 | 9.99 | 8 | 113592 | 16371 | 64368761 |
Injection site bruising | 10.57 | 9.99 | 31 | 113569 | 36342 | 64348790 |
Wrong technique in product usage process | 10.54 | 9.99 | 69 | 113531 | 64905 | 64320227 |
Dyspnoea | 10.52 | 9.99 | 1107 | 112493 | 717567 | 63667565 |
Swelling | 10.46 | 9.99 | 209 | 113391 | 160009 | 64225123 |
Mean platelet volume decreased | 10.39 | 9.99 | 14 | 113586 | 1717 | 64383415 |
Scratch | 10.38 | 9.99 | 30 | 113570 | 6459 | 64378673 |
Upper respiratory tract infection | 10.34 | 9.99 | 183 | 113417 | 72602 | 64312530 |
Intestinal resection | 10.30 | 9.99 | 19 | 113581 | 3049 | 64382083 |
Pemphigoid | 10.27 | 9.99 | 5 | 113595 | 12981 | 64372151 |
Central nervous system lesion | 10.26 | 9.99 | 4 | 113596 | 11845 | 64373287 |
Intestinal pseudo-obstruction | 10.26 | 9.99 | 15 | 113585 | 1985 | 64383147 |
Post procedural pulmonary embolism | 10.23 | 9.99 | 6 | 113594 | 239 | 64384893 |
Chronic kidney disease | 10.18 | 9.99 | 60 | 113540 | 57859 | 64327273 |
Gross motor delay | 10.15 | 9.99 | 4 | 113596 | 64 | 64385068 |
Fistula | 10.14 | 9.99 | 39 | 113561 | 9722 | 64375410 |
Toxicity to various agents | 10.11 | 9.99 | 757 | 112843 | 362756 | 64022376 |
Cerebrospinal fluid leakage | 10.08 | 9.99 | 12 | 113588 | 1300 | 64383832 |
Blood triglycerides increased | 10.07 | 9.99 | 11 | 113589 | 18855 | 64366277 |
Immunoglobulins decreased | 10.04 | 9.99 | 12 | 113588 | 1306 | 64383826 |
Rubella | 10.00 | 9.99 | 5 | 113595 | 144 | 64384988 |
None
Source | Code | Description |
---|---|---|
ATC | N02AA03 | NERVOUS SYSTEM ANALGESICS OPIOIDS Natural opium alkaloids |
ATC | N02AA53 | NERVOUS SYSTEM ANALGESICS OPIOIDS Natural opium alkaloids |
ATC | N02AG04 | NERVOUS SYSTEM ANALGESICS OPIOIDS Opioids in combination with antispasmodics |
MeSH PA | D000700 | Analgesics |
MeSH PA | D000701 | Analgesics, Opioid |
MeSH PA | D002491 | Central Nervous System Agents |
MeSH PA | D002492 | Central Nervous System Depressants |
MeSH PA | D009294 | Narcotics |
MeSH PA | D018373 | Peripheral Nervous System Agents |
MeSH PA | D018689 | Sensory System Agents |
CHEBI has role | CHEBI:35482 | narcotic analgesic |
CHEBI has role | CHEBI:55322 | mu-opioid agonists |
FDA MoA | N0000175684 | Full Opioid Agonists |
FDA EPC | N0000175690 | Opioid Agonist |
Disease | Relation | SNOMED_ID | DOID |
---|---|---|---|
Pain | indication | 22253000 | |
Cough | indication | 49727002 | |
Severe pain | indication | 76948002 | |
Common cold | indication | 82272006 | DOID:10459 |
Acute postoperative pain | indication | 107401000119105 | |
Severe Pain with Opioid Tolerance | indication | ||
Chronic Pain with Opioid Tolerance | indication | ||
Suicidal thoughts | contraindication | 6471006 | |
Dependent drug abuse | contraindication | 6525002 | |
Alcohol withdrawal delirium | contraindication | 8635005 | |
Asthenia | contraindication | 13791008 | |
Constipation | contraindication | 14760008 | DOID:2089 |
Mood swings | contraindication | 18963009 | |
Inflammatory bowel disease | contraindication | 24526004 | DOID:0050589 |
Alcohol intoxication | contraindication | 25702006 | |
Complete atrioventricular block | contraindication | 27885002 | |
Shock | contraindication | 27942005 | |
Hypercapnia | contraindication | 29596007 | |
Dehydration | contraindication | 34095006 | |
Disorder of gallbladder | contraindication | 39621005 | DOID:0060262 |
Hypothyroidism | contraindication | 40930008 | DOID:1459 |
Conduction disorder of the heart | contraindication | 44808001 | |
Low blood pressure | contraindication | 45007003 | |
Bradycardia | contraindication | 48867003 | |
Hepatic failure | contraindication | 59927004 | |
Ulcerative colitis | contraindication | 64766004 | DOID:8577 |
Substance abuse | contraindication | 66214007 | |
Benign intracranial hypertension | contraindication | 68267002 | DOID:11459 |
Urethral stricture | contraindication | 76618002 | |
Decreased respiratory function | contraindication | 80954004 | |
Injury of head | contraindication | 82271004 | |
Cor pulmonale | contraindication | 83291003 | DOID:8515 |
Pulmonary emphysema | contraindication | 87433001 | |
Kidney disease | contraindication | 90708001 | DOID:557 |
Acute abdominal pain | contraindication | 116290004 | |
Neoplasm of brain | contraindication | 126952004 | DOID:1319 |
Seizure disorder | contraindication | 128613002 | |
Drug-induced psychosis | contraindication | 191483003 | DOID:1742 |
Disease of liver | contraindication | 235856003 | DOID:409 |
Morbid obesity | contraindication | 238136002 | DOID:11981 |
Sepsis syndrome | contraindication | 238150007 | |
Benign prostatic hyperplasia | contraindication | 266569009 | |
Retention of urine | contraindication | 267064002 | |
Exacerbation of asthma | contraindication | 281239006 | |
Lesion of brain | contraindication | 301766008 | |
Deficiency of cholinesterase | contraindication | 360607009 | |
Coma | contraindication | 371632003 | |
Primary adrenocortical insufficiency | contraindication | 373662000 | |
Operation on gastrointestinal tract | contraindication | 386621005 | |
Hypoxia | contraindication | 389086002 | |
Central nervous system depression | contraindication | 418072004 | |
Dysfunction of sphincter of Oddi | contraindication | 430887001 |
None
None
Dissociation level | Dissociation constant | Type (acidic/basic) |
---|---|---|
pKa1 | 9.67 | acidic |
pKa2 | 8.64 | Basic |
None
None
Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
---|---|---|---|---|---|---|---|---|---|
Mu-type opioid receptor | GPCR | AGONIST | Ki | 9.55 | CHEMBL | CHEMBL | |||
Kappa-type opioid receptor | GPCR | Ki | 8.55 | CHEMBL | |||||
Delta-type opioid receptor | GPCR | Ki | 7.42 | CHEMBL | |||||
Opioid receptor | GPCR | EC50 | 9 | CHEMBL |
ID | Source |
---|---|
4019779 | VUID |
N0000147870 | NUI |
D00839 | KEGG_DRUG |
71-68-1 | SECONDARY_CAS_RN |
4018035 | VANDF |
4019779 | VANDF |
C0012306 | UMLSCUI |
CHEBI:5790 | CHEBI |
CHEMBL398707 | ChEMBL_ID |
DB00327 | DRUGBANK_ID |
CHEMBL1237055 | ChEMBL_ID |
D004091 | MESH_DESCRIPTOR_UI |
5284570 | PUBCHEM_CID |
7082 | IUPHAR_LIGAND_ID |
1770 | INN_ID |
Q812464R06 | UNII |
203177 | RXNORM |
1470 | MMSL |
4848 | MMSL |
7015 | MMSL |
d00255 | MMSL |
001547 | NDDF |
004622 | NDDF |
387485001 | SNOMEDCT_US |
414428000 | SNOMEDCT_US |
44508008 | SNOMEDCT_US |
Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
---|---|---|---|---|---|---|---|---|
Hydromorphone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-0264 | TABLET | 4 mg | ORAL | ANDA | 33 sections |
Hydromorphone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-0264 | TABLET | 4 mg | ORAL | ANDA | 33 sections |
Hydromorphone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-0265 | TABLET | 8 mg | ORAL | ANDA | 33 sections |
Hydromorphone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-0265 | TABLET | 8 mg | ORAL | ANDA | 33 sections |
Hydromorphone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-0386 | SOLUTION | 1 mg | ORAL | ANDA | 33 sections |
Hydromorphone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-0386 | SOLUTION | 1 mg | ORAL | ANDA | 33 sections |
Hydromorphone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0406-3243 | TABLET | 2 mg | ORAL | ANDA | 37 sections |
Hydromorphone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0406-3244 | TABLET | 4 mg | ORAL | ANDA | 37 sections |
Hydromorphone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0406-3249 | TABLET | 8 mg | ORAL | ANDA | 37 sections |
Hydromorphone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-1283 | INJECTION, SOLUTION | 1 mg | INTRAMUSCULAR | NDA | 35 sections |
Hydromorphone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-1283 | INJECTION, SOLUTION | 1 mg | INTRAMUSCULAR | NDA | 35 sections |
Hydromorphone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-1283 | INJECTION, SOLUTION | 1 mg | INTRAMUSCULAR | NDA | 35 sections |
Hydromorphone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-1304 | INJECTION, SOLUTION | 4 mg | INTRAMUSCULAR | NDA | 33 sections |
Hydromorphone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-1312 | INJECTION, SOLUTION | 2 mg | INTRAMUSCULAR | NDA | 35 sections |
Hydromorphone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-1312 | INJECTION, SOLUTION | 2 mg | INTRAMUSCULAR | NDA | 35 sections |
Hydromorphone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-1312 | INJECTION, SOLUTION | 2 mg | INTRAMUSCULAR | NDA | 35 sections |
Hydromorphone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-1380 | INJECTION, SOLUTION | 4 mg | INTRAMUSCULAR | NDA | 35 sections |
Hydromorphone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-1380 | INJECTION, SOLUTION | 4 mg | INTRAMUSCULAR | NDA | 35 sections |
Hydromorphone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-2540 | INJECTION, SOLUTION | 4 mg | INTRAMUSCULAR | NDA | 33 sections |
Hydromorphone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-2552 | INJECTION, SOLUTION | 1 mg | INTRAMUSCULAR | NDA | 33 sections |
Hydromorphone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-2634 | INJECTION, SOLUTION | 10 mg | INTRAMUSCULAR | ANDA | 34 sections |
Hydromorphone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-2634 | INJECTION, SOLUTION | 10 mg | INTRAMUSCULAR | ANDA | 34 sections |
Hydromorphone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-3356 | INJECTION, SOLUTION | 2 mg | INTRAMUSCULAR | NDA | 33 sections |
Hydromorphone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-3365 | INJECTION, SOLUTION | 2 mg | INTRAMUSCULAR | NDA | 33 sections |
Hydromorphone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-4264 | INJECTION, SOLUTION | 0.50 mg | INTRAMUSCULAR | NDA | 35 sections |
Hydromorphone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0527-1353 | TABLET | 2 mg | ORAL | ANDA | 32 sections |
Hydromorphone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0527-1354 | TABLET | 4 mg | ORAL | ANDA | 32 sections |
Hydromorphone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0527-1355 | TABLET | 8 mg | ORAL | ANDA | 32 sections |
Hydromorphone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0527-1873 | SOLUTION | 5 mg | ORAL | ANDA | 30 sections |
hydromorphone hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0574-0293 | TABLET, EXTENDED RELEASE | 8 mg | ORAL | ANDA | 33 sections |