hydromorphone Indications/Contra | FAERs-F | FAERs-M | Orange Bk | BioActivity |
| Stem definition | Drug id | CAS RN |
|---|---|---|
| opioid receptor antagonists/agonists, morphinan derivates | 1393 | 466-99-9 |
Description:
| Molecule | Description |
|---|---|
|
Synonyms:
|
An opioid analgesic made from MORPHINE and used mainly as an analgesic. It has a shorter duration of action than morphine.
Legend: OFP - off patent OFM - off market ONP - on patent |
Drug dosage:
| Dose | Unit | Route |
|---|---|---|
| 20 | mg | O |
| 4 | mg | P |
| 4 | mg | R |
ADMET properties:
| Property | Value | Reference |
|---|---|---|
| BDDCS (Biopharmaceutical Drug Disposition Classification System) | 1 | Benet LZ, Broccatelli F, Oprea TI |
| S (Water solubility) | 10 mg/mL | Benet LZ, Broccatelli F, Oprea TI |
| EoM (Fraction excreted unchanged in urine) | 6 % | Benet LZ, Broccatelli F, Oprea TI |
| MRTD (Maximum Recommended Therapeutic Daily Dose) | 1.20 µM/kg/day | Contrera JF, Matthews EJ, Kruhlak NL, Benz RD |
| BA (Bioavailability) | 42 % | Kim MT, Sedykh A, Chakravarti SK, Saiakhov RD, Zhu H |
| Vd (Volume of distribution) | 4.30 L/kg | Lombardo F, Berellini G, Obach RS |
| CL (Clearance) | 28 mL/min/kg | Lombardo F, Berellini G, Obach RS |
| fu (Fraction unbound in plasma) | 0.86 % | Lombardo F, Berellini G, Obach RS |
| t_half (Half-life) | 2.30 hours | Lombardo F, Berellini G, Obach RS |
Approvals:
| Date | Agency | Company | Orphan |
|---|---|---|---|
| Jan. 11, 1984 | FDA | PURDUE PHARM PRODS |
FDA Adverse Event Reporting System (Female)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Drug hypersensitivity | 379.72 | 9.80 | 1125 | 82421 | 242700 | 46359816 |
| Temperature regulation disorder | 192.84 | 9.80 | 102 | 83444 | 3258 | 46599258 |
| Pneumonia viral | 162.79 | 9.80 | 117 | 83429 | 6507 | 46596009 |
| Pain | 156.25 | 9.80 | 1416 | 82130 | 475532 | 46126984 |
| Drug withdrawal syndrome | 137.53 | 9.80 | 205 | 83341 | 27179 | 46575337 |
| Food allergy | 131.71 | 9.80 | 105 | 83441 | 6828 | 46595688 |
| Pneumonia aspiration | 128.81 | 9.80 | 215 | 83331 | 31390 | 46571126 |
| Soft tissue disorder | 126.56 | 9.80 | 84 | 83462 | 4102 | 46598414 |
| Unresponsive to stimuli | 124.68 | 9.80 | 214 | 83332 | 31960 | 46570556 |
| Coeliac disease | 124.53 | 9.80 | 103 | 83443 | 7058 | 46595458 |
| Drug dependence | 117.61 | 9.80 | 161 | 83385 | 19740 | 46582776 |
| Delirium | 101.31 | 9.80 | 213 | 83333 | 37015 | 46565501 |
| Somnolence | 100.99 | 9.80 | 549 | 82997 | 155972 | 46446544 |
| Synovitis | 100.53 | 9.80 | 288 | 83258 | 60787 | 46541729 |
| Bursitis | 100.28 | 9.80 | 149 | 83397 | 19693 | 46582823 |
| Immunodeficiency | 97.78 | 9.80 | 119 | 83427 | 12987 | 46589529 |
| Hyperaesthesia | 87.49 | 9.80 | 88 | 83458 | 7768 | 46594748 |
| Respiratory depression | 86.01 | 9.80 | 105 | 83441 | 11495 | 46591021 |
| Respiratory rate decreased | 81.19 | 9.80 | 57 | 83489 | 3053 | 46599463 |
| Extremity contracture | 76.57 | 9.80 | 39 | 83507 | 1150 | 46601366 |
| Constipation | 73.35 | 9.80 | 548 | 82998 | 173549 | 46428967 |
| Inadequate analgesia | 71.96 | 9.80 | 51 | 83495 | 2773 | 46599743 |
| Alopecia | 69.21 | 9.80 | 115 | 83431 | 162299 | 46440217 |
| Arthritis | 67.62 | 9.80 | 296 | 83250 | 77020 | 46525496 |
| Coma | 66.79 | 9.80 | 243 | 83303 | 58106 | 46544410 |
| Pemphigus | 65.02 | 9.80 | 4 | 83542 | 45270 | 46557246 |
| Hypermobility syndrome | 64.22 | 9.80 | 29 | 83517 | 650 | 46601866 |
| Oral pain | 59.63 | 9.80 | 135 | 83411 | 24662 | 46577854 |
| Ankylosing spondylitis | 56.59 | 9.80 | 65 | 83481 | 6672 | 46595844 |
| Back pain | 56.31 | 9.80 | 599 | 82947 | 209440 | 46393076 |
| Injection site erythema | 55.62 | 9.80 | 32 | 83514 | 74395 | 46528121 |
| Fibromyalgia | 54.31 | 9.80 | 166 | 83380 | 36297 | 46566219 |
| Drug interaction | 51.04 | 9.80 | 189 | 83357 | 202905 | 46399611 |
| Nausea | 49.96 | 9.80 | 1594 | 81952 | 685860 | 45916656 |
| Herpes zoster | 49.88 | 9.80 | 247 | 83299 | 67625 | 46534891 |
| Sedation | 48.84 | 9.80 | 119 | 83427 | 22791 | 46579725 |
| Malignant neoplasm progression | 47.51 | 9.80 | 236 | 83310 | 64690 | 46537826 |
| Medical device site pain | 46.74 | 9.80 | 17 | 83529 | 212 | 46602304 |
| Exposure during pregnancy | 46.65 | 9.80 | 76 | 83470 | 108136 | 46494380 |
| Drug abuse | 46.06 | 9.80 | 230 | 83316 | 63178 | 46539338 |
| Respiratory arrest | 45.82 | 9.80 | 149 | 83397 | 33667 | 46568849 |
| Device related thrombosis | 45.48 | 9.80 | 28 | 83518 | 1199 | 46601317 |
| Intentional overdose | 44.30 | 9.80 | 31 | 83515 | 64913 | 46537603 |
| Narcotic bowel syndrome | 43.39 | 9.80 | 14 | 83532 | 118 | 46602398 |
| Sickle cell anaemia with crisis | 43.14 | 9.80 | 44 | 83502 | 3948 | 46598568 |
| Myocardial infarction | 42.50 | 9.80 | 68 | 83478 | 97460 | 46505056 |
| Implant site extravasation | 42.29 | 9.80 | 20 | 83526 | 500 | 46602016 |
| Overdose | 41.76 | 9.80 | 319 | 83227 | 101660 | 46500856 |
| Maternal exposure during pregnancy | 41.48 | 9.80 | 75 | 83471 | 102474 | 46500042 |
| Drug tolerance | 41.37 | 9.80 | 39 | 83507 | 3179 | 46599337 |
| Drug diversion | 40.72 | 9.80 | 23 | 83523 | 838 | 46601678 |
| Neoplasm progression | 40.22 | 9.80 | 122 | 83424 | 26561 | 46575955 |
| Injection site pain | 40.17 | 9.80 | 82 | 83464 | 107070 | 46495446 |
| Hepatic function abnormal | 39.39 | 9.80 | 7 | 83539 | 34414 | 46568102 |
| Injection site swelling | 38.66 | 9.80 | 12 | 83534 | 40315 | 46562201 |
| Renal impairment | 38.27 | 9.80 | 46 | 83500 | 74326 | 46528190 |
| Device expulsion | 37.90 | 9.80 | 3 | 83543 | 27539 | 46574977 |
| Glossodynia | 37.80 | 9.80 | 16 | 83530 | 44357 | 46558159 |
| Interstitial lung disease | 37.80 | 9.80 | 25 | 83521 | 53924 | 46548592 |
| Hereditary angioedema | 37.80 | 9.80 | 48 | 83498 | 5468 | 46597048 |
| Scar | 37.73 | 9.80 | 73 | 83473 | 11946 | 46590570 |
| Vomiting | 37.34 | 9.80 | 1067 | 82479 | 451727 | 46150789 |
| Cardiac failure congestive | 37.19 | 9.80 | 67 | 83479 | 91683 | 46510833 |
| Product dose omission issue | 37.18 | 9.80 | 165 | 83381 | 168355 | 46434161 |
| Abortion spontaneous | 36.76 | 9.80 | 16 | 83530 | 43630 | 46558886 |
| Completed suicide | 36.69 | 9.80 | 411 | 83135 | 145509 | 46457007 |
| Lactic acidosis | 36.49 | 9.80 | 8 | 83538 | 33901 | 46568615 |
| Drug reaction with eosinophilia and systemic symptoms | 36.10 | 9.80 | 5 | 83541 | 29543 | 46572973 |
| Hyponatraemia | 35.93 | 9.80 | 80 | 83466 | 101252 | 46501264 |
| Postmortem blood drug level increased | 35.83 | 9.80 | 17 | 83529 | 428 | 46602088 |
| Apnoea | 35.49 | 9.80 | 54 | 83492 | 7285 | 46595231 |
| Hyperhidrosis | 35.25 | 9.80 | 277 | 83269 | 89031 | 46513485 |
| Rash | 34.00 | 9.80 | 442 | 83104 | 356070 | 46246446 |
| Systemic lupus erythematosus | 32.81 | 9.80 | 41 | 83505 | 65139 | 46537377 |
| Pustular psoriasis | 32.47 | 9.80 | 38 | 83508 | 3979 | 46598537 |
| Hypertensive encephalopathy | 31.94 | 9.80 | 18 | 83528 | 653 | 46601863 |
| Mental status changes | 31.90 | 9.80 | 144 | 83402 | 37944 | 46564572 |
| Hepatocellular injury | 31.70 | 9.80 | 7 | 83539 | 29515 | 46573001 |
| Gastrooesophageal reflux disease | 31.23 | 9.80 | 234 | 83312 | 74110 | 46528406 |
| Compartment syndrome | 31.15 | 9.80 | 27 | 83519 | 1972 | 46600544 |
| Injection site reaction | 31.12 | 9.80 | 24 | 83522 | 47825 | 46554691 |
| Abdominal pain | 30.68 | 9.80 | 580 | 82966 | 229451 | 46373065 |
| Small intestinal obstruction | 30.30 | 9.80 | 80 | 83466 | 16092 | 46586424 |
| Injection site pruritus | 29.81 | 9.80 | 17 | 83529 | 39726 | 46562790 |
| Foetal exposure during pregnancy | 29.74 | 9.80 | 9 | 83537 | 30738 | 46571778 |
| Treatment failure | 29.44 | 9.80 | 78 | 83468 | 93009 | 46509507 |
| Rheumatoid factor negative | 29.41 | 9.80 | 16 | 83530 | 541 | 46601975 |
| Acute chest syndrome | 29.07 | 9.80 | 16 | 83530 | 554 | 46601962 |
| Rash erythematous | 28.87 | 9.80 | 130 | 83416 | 34220 | 46568296 |
| Neutropenia | 28.77 | 9.80 | 145 | 83401 | 143059 | 46459457 |
| Hepatitis | 28.44 | 9.80 | 11 | 83535 | 32204 | 46570312 |
| Cardiac failure | 28.44 | 9.80 | 63 | 83483 | 79885 | 46522631 |
| Head banging | 27.57 | 9.80 | 14 | 83532 | 410 | 46602106 |
| Toxicity to various agents | 27.56 | 9.80 | 532 | 83014 | 211234 | 46391282 |
| Anaphylactic reaction | 27.52 | 9.80 | 176 | 83370 | 52936 | 46549580 |
| Bursitis infective | 27.12 | 9.80 | 20 | 83526 | 1157 | 46601359 |
| No adverse event | 26.61 | 9.80 | 14 | 83532 | 34217 | 46568299 |
| Lower respiratory tract infection | 26.34 | 9.80 | 36 | 83510 | 55053 | 46547463 |
| Cough | 25.55 | 9.80 | 276 | 83270 | 229973 | 46372543 |
| Intentional self-injury | 25.40 | 9.80 | 6 | 83540 | 24160 | 46578356 |
| Infection | 25.31 | 9.80 | 357 | 83189 | 133235 | 46469281 |
| Tenderness | 25.27 | 9.80 | 77 | 83469 | 16804 | 46585712 |
| Postoperative ileus | 25.22 | 9.80 | 14 | 83532 | 493 | 46602023 |
| Rheumatoid arthritis | 24.96 | 9.80 | 584 | 82962 | 239631 | 46362885 |
| Acute kidney injury | 24.88 | 9.80 | 286 | 83260 | 235569 | 46366947 |
| Rhesus antigen positive | 24.84 | 9.80 | 9 | 83537 | 111 | 46602405 |
| Peripheral swelling | 24.77 | 9.80 | 409 | 83137 | 157662 | 46444854 |
| Platelet aggregation inhibition | 24.55 | 9.80 | 9 | 83537 | 115 | 46602401 |
| Infusion site mass | 24.37 | 9.80 | 17 | 83529 | 901 | 46601615 |
| Anti-cyclic citrullinated peptide antibody positive | 23.96 | 9.80 | 3 | 83543 | 19142 | 46583374 |
| Spinal cord compression | 23.59 | 9.80 | 31 | 83515 | 3653 | 46598863 |
| Immunoglobulins decreased | 23.24 | 9.80 | 16 | 83530 | 830 | 46601686 |
| Cancer pain | 22.91 | 9.80 | 25 | 83521 | 2425 | 46600091 |
| Pregnancy | 22.77 | 9.80 | 10 | 83536 | 27127 | 46575389 |
| Screaming | 22.23 | 9.80 | 28 | 83518 | 3163 | 46599353 |
| Abdominal discomfort | 22.07 | 9.80 | 169 | 83377 | 150996 | 46451520 |
| Post procedural complication | 21.93 | 9.80 | 70 | 83476 | 15659 | 46586857 |
| Overwork | 21.91 | 9.80 | 7 | 83539 | 57 | 46602459 |
| Eosinophilia | 21.79 | 9.80 | 4 | 83542 | 19213 | 46583303 |
| Intestinal pseudo-obstruction | 21.66 | 9.80 | 14 | 83532 | 653 | 46601863 |
| Obstruction | 21.51 | 9.80 | 20 | 83526 | 1602 | 46600914 |
| Amputation stump pain | 21.11 | 9.80 | 6 | 83540 | 31 | 46602485 |
| Breast cancer metastatic | 21.05 | 9.80 | 63 | 83483 | 13615 | 46588901 |
| Migraine | 20.76 | 9.80 | 204 | 83342 | 69822 | 46532694 |
| Antidepressant drug level above therapeutic | 20.72 | 9.80 | 11 | 83535 | 354 | 46602162 |
| Localised infection | 20.69 | 9.80 | 91 | 83455 | 23710 | 46578806 |
| Malignant polyp | 20.56 | 9.80 | 9 | 83537 | 187 | 46602329 |
| Blood cholesterol increased | 20.36 | 9.80 | 132 | 83414 | 39881 | 46562635 |
| Drug intolerance | 20.35 | 9.80 | 373 | 83173 | 146676 | 46455840 |
| Syncope | 19.98 | 9.80 | 108 | 83438 | 104695 | 46497821 |
| Blood pressure systolic increased | 19.90 | 9.80 | 103 | 83443 | 28684 | 46573832 |
| Respiratory syncytial virus infection | 19.83 | 9.80 | 33 | 83513 | 4802 | 46597714 |
| Extradural haematoma | 19.75 | 9.80 | 18 | 83528 | 1405 | 46601111 |
| Breast cancer | 19.57 | 9.80 | 32 | 83514 | 45486 | 46557030 |
| Bronchomalacia | 19.53 | 9.80 | 8 | 83538 | 140 | 46602376 |
| Cholestasis | 19.47 | 9.80 | 12 | 83534 | 26881 | 46575635 |
| Emotional distress | 19.27 | 9.80 | 107 | 83439 | 30600 | 46571916 |
| Wrong technique in product usage process | 19.25 | 9.80 | 43 | 83503 | 54379 | 46548137 |
| Substance abuse | 19.22 | 9.80 | 30 | 83516 | 4137 | 46598379 |
| Diarrhoea | 18.96 | 9.80 | 814 | 82732 | 558788 | 46043728 |
| Foreign body embolism | 18.55 | 9.80 | 4 | 83542 | 4 | 46602512 |
| Pericarditis | 18.28 | 9.80 | 10 | 83536 | 23917 | 46578599 |
| Vitamin K deficiency | 18.25 | 9.80 | 11 | 83535 | 453 | 46602063 |
| Ligament pain | 18.11 | 9.80 | 8 | 83538 | 170 | 46602346 |
| Premature baby | 18.07 | 9.80 | 5 | 83541 | 18107 | 46584409 |
| Epilepsy | 18.02 | 9.80 | 10 | 83536 | 23728 | 46578788 |
| Dizziness | 17.91 | 9.80 | 468 | 83078 | 339946 | 46262570 |
| Accidental overdose | 17.66 | 9.80 | 77 | 83469 | 19989 | 46582527 |
| Alveolitis | 17.43 | 9.80 | 22 | 83524 | 2491 | 46600025 |
| Psoriasis | 17.29 | 9.80 | 77 | 83469 | 78527 | 46523989 |
| Fluid retention | 17.28 | 9.80 | 153 | 83393 | 50893 | 46551623 |
| Defaecation disorder | 17.00 | 9.80 | 9 | 83537 | 288 | 46602228 |
| Therapeutic product effect incomplete | 16.92 | 9.80 | 214 | 83332 | 77939 | 46524577 |
| Metastases to bone | 16.88 | 9.80 | 69 | 83477 | 17407 | 46585109 |
| Hepatic cirrhosis | 16.72 | 9.80 | 64 | 83482 | 15668 | 46586848 |
| Pulmonary embolism | 16.65 | 9.80 | 280 | 83266 | 108305 | 46494211 |
| Plasma cell myeloma | 16.47 | 9.80 | 136 | 83410 | 44342 | 46558174 |
| Allodynia | 16.45 | 9.80 | 11 | 83535 | 544 | 46601972 |
| Bradycardia | 16.43 | 9.80 | 62 | 83484 | 66236 | 46536280 |
| Red cell distribution width increased | 16.40 | 9.80 | 40 | 83506 | 7664 | 46594852 |
| Blood immunoglobulin M decreased | 16.20 | 9.80 | 12 | 83534 | 699 | 46601817 |
| Faecal volume decreased | 16.05 | 9.80 | 7 | 83539 | 144 | 46602372 |
| Limb mass | 15.99 | 9.80 | 21 | 83525 | 2473 | 46600043 |
| Carbohydrate antigen 19-9 increased | 15.88 | 9.80 | 7 | 83539 | 148 | 46602368 |
| Joint dislocation | 15.79 | 9.80 | 50 | 83496 | 11136 | 46591380 |
| Angioedema | 15.69 | 9.80 | 29 | 83517 | 39313 | 46563203 |
| Status epilepticus | 15.66 | 9.80 | 3 | 83543 | 13976 | 46588540 |
| Palpitations | 15.60 | 9.80 | 103 | 83443 | 95156 | 46507360 |
| Dry eye | 15.33 | 9.80 | 19 | 83527 | 30303 | 46572213 |
| Photophobia | 15.32 | 9.80 | 59 | 83487 | 14485 | 46588031 |
| Orthostatic hypotension | 15.25 | 9.80 | 13 | 83533 | 24645 | 46577871 |
| Osteoporosis | 14.95 | 9.80 | 124 | 83422 | 40484 | 46562032 |
| Adiposis dolorosa | 14.80 | 9.80 | 8 | 83538 | 267 | 46602249 |
| Opiates positive | 14.80 | 9.80 | 8 | 83538 | 267 | 46602249 |
| Rash pruritic | 14.79 | 9.80 | 36 | 83510 | 44179 | 46558337 |
| Drug eruption | 14.78 | 9.80 | 10 | 83536 | 21319 | 46581197 |
| White blood cell count decreased | 14.76 | 9.80 | 129 | 83417 | 112102 | 46490414 |
| Heart rate increased | 14.61 | 9.80 | 201 | 83345 | 74590 | 46527926 |
| Bone marrow failure | 14.58 | 9.80 | 19 | 83527 | 29650 | 46572866 |
| Intestinal metastasis | 14.56 | 9.80 | 5 | 83541 | 52 | 46602464 |
| Incorrect route of product administration | 14.52 | 9.80 | 63 | 83483 | 16320 | 46586196 |
| Multiple sclerosis relapse | 14.32 | 9.80 | 34 | 83512 | 42091 | 46560425 |
| Apnoeic attack | 14.30 | 9.80 | 8 | 83538 | 286 | 46602230 |
| Ischaemic stroke | 14.29 | 9.80 | 6 | 83540 | 16716 | 46585800 |
| Virologic failure | 14.27 | 9.80 | 18 | 83528 | 2037 | 46600479 |
| Toxicologic test abnormal | 14.17 | 9.80 | 11 | 83535 | 688 | 46601828 |
| Cerebrospinal fluid leakage | 14.15 | 9.80 | 12 | 83534 | 851 | 46601665 |
| Toxic leukoencephalopathy | 14.12 | 9.80 | 10 | 83536 | 543 | 46601973 |
| Caesarean section | 14.12 | 9.80 | 6 | 83540 | 16597 | 46585919 |
| Liver function test abnormal | 14.06 | 9.80 | 136 | 83410 | 46351 | 46556165 |
| Device power source issue | 13.96 | 9.80 | 9 | 83537 | 418 | 46602098 |
| Foreign body reaction | 13.92 | 9.80 | 5 | 83541 | 60 | 46602456 |
| Silicon granuloma | 13.91 | 9.80 | 3 | 83543 | 3 | 46602513 |
| Device failure | 13.83 | 9.80 | 32 | 83514 | 5927 | 46596589 |
| Pneumocystis jirovecii pneumonia | 13.81 | 9.80 | 5 | 83541 | 15243 | 46587273 |
| Neuralgia | 13.74 | 9.80 | 75 | 83471 | 21308 | 46581208 |
| Soft tissue swelling | 13.73 | 9.80 | 12 | 83534 | 886 | 46601630 |
| Psychiatric symptom | 13.73 | 9.80 | 27 | 83519 | 4470 | 46598046 |
| Exostosis | 13.70 | 9.80 | 45 | 83501 | 10218 | 46592298 |
| Atelectasis | 13.52 | 9.80 | 68 | 83478 | 18722 | 46583794 |
| Device infusion issue | 13.52 | 9.80 | 13 | 83533 | 1086 | 46601430 |
| Procedural pain | 13.50 | 9.80 | 53 | 83493 | 13126 | 46589390 |
| Melaena | 13.42 | 9.80 | 18 | 83528 | 27754 | 46574762 |
| Pulmonary arterial hypertension | 13.37 | 9.80 | 16 | 83530 | 25912 | 46576604 |
| Substance dependence | 13.36 | 9.80 | 7 | 83539 | 219 | 46602297 |
| Eye operation | 13.36 | 9.80 | 16 | 83530 | 1716 | 46600800 |
| Suicide attempt | 13.29 | 9.80 | 52 | 83494 | 54984 | 46547532 |
| Cytomegalovirus infection | 13.27 | 9.80 | 8 | 83538 | 18136 | 46584380 |
| Rib fracture | 13.22 | 9.80 | 68 | 83478 | 18886 | 46583630 |
| Red blood cell sedimentation rate abnormal | 13.19 | 9.80 | 4 | 83542 | 13645 | 46588871 |
| Dyspnoea | 13.16 | 9.80 | 772 | 82774 | 514776 | 46087740 |
| Toe amputation | 12.91 | 9.80 | 17 | 83529 | 2007 | 46600509 |
| Pancreatitis | 12.88 | 9.80 | 127 | 83419 | 43500 | 46559016 |
| Alanine aminotransferase increased | 12.85 | 9.80 | 99 | 83447 | 88352 | 46514164 |
| Tachyphylaxis | 12.75 | 9.80 | 7 | 83539 | 241 | 46602275 |
| Presyncope | 12.71 | 9.80 | 15 | 83531 | 24439 | 46578077 |
| Implant site haematoma | 12.67 | 9.80 | 5 | 83541 | 79 | 46602437 |
| Drug ineffective | 12.66 | 9.80 | 1391 | 82155 | 676447 | 45926069 |
| Respiratory failure | 12.58 | 9.80 | 239 | 83307 | 94577 | 46507939 |
| Asthma | 12.58 | 9.80 | 232 | 83314 | 91310 | 46511206 |
| Balance disorder | 12.56 | 9.80 | 66 | 83480 | 64455 | 46538061 |
| Respiratory rate increased | 12.55 | 9.80 | 47 | 83499 | 11386 | 46591130 |
| Injection site urticaria | 12.52 | 9.80 | 3 | 83543 | 11964 | 46590552 |
| Cholangitis sclerosing | 12.47 | 9.80 | 12 | 83534 | 1003 | 46601513 |
| Ileus | 12.40 | 9.80 | 54 | 83492 | 14010 | 46588506 |
| Perineal pain | 12.39 | 9.80 | 7 | 83539 | 255 | 46602261 |
| Bacteraemia | 12.16 | 9.80 | 54 | 83492 | 14125 | 46588391 |
| Swollen tongue | 12.15 | 9.80 | 21 | 83525 | 29211 | 46573305 |
| Visual acuity reduced | 12.11 | 9.80 | 13 | 83533 | 22100 | 46580416 |
| Intestinal obstruction | 12.05 | 9.80 | 84 | 83462 | 25991 | 46576525 |
| Hypercapnia | 12.04 | 9.80 | 26 | 83520 | 4600 | 46597916 |
| Wound infection bacterial | 12.01 | 9.80 | 8 | 83538 | 393 | 46602123 |
| Gastrointestinal haemorrhage | 12.00 | 9.80 | 85 | 83461 | 77288 | 46525228 |
| Transient ischaemic attack | 12.00 | 9.80 | 28 | 83518 | 34875 | 46567641 |
| Ocular procedural complication | 11.96 | 9.80 | 7 | 83539 | 273 | 46602243 |
| Implant site pain | 11.90 | 9.80 | 17 | 83529 | 2167 | 46600349 |
| Joint swelling | 11.90 | 9.80 | 385 | 83161 | 165688 | 46436828 |
| Eastern Cooperative Oncology Group performance status worsened | 11.83 | 9.80 | 8 | 83538 | 403 | 46602113 |
| Shock | 11.78 | 9.80 | 13 | 83533 | 21832 | 46580684 |
| Learning disability | 11.78 | 9.80 | 5 | 83541 | 96 | 46602420 |
| Serotonin syndrome | 11.78 | 9.80 | 79 | 83467 | 24141 | 46578375 |
| Chest discomfort | 11.76 | 9.80 | 104 | 83442 | 90165 | 46512351 |
| Dental caries | 11.67 | 9.80 | 43 | 83503 | 10336 | 46592180 |
| Injection site warmth | 11.67 | 9.80 | 5 | 83541 | 13767 | 46588749 |
| Intestinal resection | 11.63 | 9.80 | 17 | 83529 | 2213 | 46600303 |
| Sopor | 11.60 | 9.80 | 11 | 83535 | 19817 | 46582699 |
| Biliary tract infection | 11.57 | 9.80 | 8 | 83538 | 418 | 46602098 |
| Sinusitis | 11.56 | 9.80 | 163 | 83383 | 129605 | 46472911 |
| Ocular hyperaemia | 11.46 | 9.80 | 11 | 83535 | 19699 | 46582817 |
| Electrocardiogram QT prolonged | 11.45 | 9.80 | 50 | 83496 | 51275 | 46551241 |
| Death | 11.45 | 9.80 | 721 | 82825 | 334827 | 46267689 |
| Implant site infection | 11.43 | 9.80 | 11 | 83535 | 920 | 46601596 |
| Nerve block | 11.40 | 9.80 | 8 | 83538 | 428 | 46602088 |
| Hypocalcaemia | 11.36 | 9.80 | 19 | 83527 | 26766 | 46575750 |
| Anaesthetic complication neurological | 11.27 | 9.80 | 6 | 83540 | 194 | 46602322 |
| Hypoxia | 11.24 | 9.80 | 142 | 83404 | 51696 | 46550820 |
| Eye irritation | 11.23 | 9.80 | 8 | 83538 | 16606 | 46585910 |
| Device computer issue | 11.18 | 9.80 | 3 | 83543 | 12 | 46602504 |
| Hypertension | 11.10 | 9.80 | 267 | 83279 | 196089 | 46406427 |
| Respiratory tract inflammation | 11.09 | 9.80 | 8 | 83538 | 447 | 46602069 |
| Accidental death | 11.07 | 9.80 | 15 | 83531 | 1820 | 46600696 |
| Multiple sclerosis | 11.06 | 9.80 | 17 | 83529 | 24774 | 46577742 |
| Seasonal allergy | 11.05 | 9.80 | 5 | 83541 | 13329 | 46589187 |
| Encephalitis brain stem | 10.95 | 9.80 | 5 | 83541 | 115 | 46602401 |
| Cardio-respiratory arrest | 10.93 | 9.80 | 159 | 83387 | 59710 | 46542806 |
| Intracranial hypotension | 10.92 | 9.80 | 7 | 83539 | 322 | 46602194 |
| Coronary artery disease | 10.88 | 9.80 | 28 | 83518 | 33724 | 46568792 |
| Monoclonal gammopathy | 10.86 | 9.80 | 9 | 83537 | 618 | 46601898 |
| Cerebrovascular accident | 10.83 | 9.80 | 122 | 83424 | 100917 | 46501599 |
| Skin laceration | 10.64 | 9.80 | 63 | 83483 | 18439 | 46584077 |
| Intestinal perforation | 10.61 | 9.80 | 43 | 83503 | 10808 | 46591708 |
| Groin pain | 10.57 | 9.80 | 38 | 83508 | 9027 | 46593489 |
| Product substitution issue | 10.48 | 9.80 | 7 | 83539 | 15024 | 46587492 |
| Product storage error | 10.45 | 9.80 | 4 | 83542 | 11788 | 46590728 |
| Blood triglycerides increased | 10.44 | 9.80 | 4 | 83542 | 11779 | 46590737 |
| Injection site bruising | 10.42 | 9.80 | 31 | 83515 | 35605 | 46566911 |
| Stevens-Johnson syndrome | 10.37 | 9.80 | 16 | 83530 | 23281 | 46579235 |
| Drug use disorder | 10.34 | 9.80 | 18 | 83528 | 2717 | 46599799 |
| Portal vein thrombosis | 10.34 | 9.80 | 17 | 83529 | 2450 | 46600066 |
| Lethargy | 10.18 | 9.80 | 138 | 83408 | 51033 | 46551483 |
| Blood pressure fluctuation | 10.17 | 9.80 | 91 | 83455 | 30357 | 46572159 |
| Rheumatoid factor positive | 10.16 | 9.80 | 13 | 83533 | 20448 | 46582068 |
| Agranulocytosis | 10.11 | 9.80 | 15 | 83531 | 22170 | 46580346 |
| Brain injury | 10.11 | 9.80 | 29 | 83517 | 6121 | 46596395 |
| Product name confusion | 10.09 | 9.80 | 4 | 83542 | 64 | 46602452 |
| COVID-19 | 10.08 | 9.80 | 11 | 83535 | 18564 | 46583952 |
| Feeling of body temperature change | 10.05 | 9.80 | 23 | 83523 | 4229 | 46598287 |
| Hypersplenism | 10.05 | 9.80 | 6 | 83540 | 243 | 46602273 |
| Live birth | 10.03 | 9.80 | 3 | 83543 | 10327 | 46592189 |
| Eye disorder | 9.94 | 9.80 | 61 | 83485 | 18080 | 46584436 |
| Abortion induced | 9.93 | 9.80 | 3 | 83543 | 10257 | 46592259 |
| Miliaria | 9.93 | 9.80 | 10 | 83536 | 884 | 46601632 |
| Pancreatolithiasis | 9.91 | 9.80 | 6 | 83540 | 249 | 46602267 |
| Poor venous access | 9.84 | 9.80 | 35 | 83511 | 8273 | 46594243 |
FDA Adverse Event Reporting System (Male)
| MedDRA adverse event term | Likelihood ratio | Likelihood ratio threshold | Patients taking drug having adverse event | Patients taking drug not having adverse event | Patients not taking drug having adverse event | Patients not taking drug not having adverse event |
|---|---|---|---|---|---|---|
| Pain | 227.60 | 10.59 | 687 | 46032 | 171954 | 29733805 |
| Hyperaesthesia | 160.47 | 10.59 | 88 | 46631 | 3485 | 29902274 |
| Drug dependence | 150.91 | 10.59 | 176 | 46543 | 21119 | 29884640 |
| Drug withdrawal syndrome | 134.20 | 10.59 | 160 | 46559 | 19649 | 29886110 |
| Sedation | 112.14 | 10.59 | 133 | 46586 | 16240 | 29889519 |
| Respiratory depression | 74.76 | 10.59 | 91 | 46628 | 11412 | 29894347 |
| Nausea | 74.08 | 10.59 | 747 | 45972 | 296210 | 29609549 |
| Back pain | 64.16 | 10.59 | 323 | 46396 | 102273 | 29803486 |
| Serotonin syndrome | 62.11 | 10.59 | 105 | 46614 | 17786 | 29887973 |
| Mental status changes | 61.78 | 10.59 | 161 | 46558 | 36918 | 29868841 |
| Toxicologic test abnormal | 60.84 | 10.59 | 26 | 46693 | 587 | 29905172 |
| Unresponsive to stimuli | 59.50 | 10.59 | 129 | 46590 | 26290 | 29879469 |
| Drug abuse | 58.24 | 10.59 | 268 | 46451 | 81804 | 29823955 |
| Drug tolerance | 52.63 | 10.59 | 36 | 46683 | 2126 | 29903633 |
| Respiratory arrest | 51.80 | 10.59 | 130 | 46589 | 29128 | 29876631 |
| Respiratory rate decreased | 50.89 | 10.59 | 33 | 46686 | 1782 | 29903977 |
| Inadequate analgesia | 49.72 | 10.59 | 38 | 46681 | 2670 | 29903089 |
| Vomiting | 49.03 | 10.59 | 541 | 46178 | 219277 | 29686482 |
| Constipation | 48.05 | 10.59 | 321 | 46398 | 112585 | 29793174 |
| Abdominal pain | 46.96 | 10.59 | 367 | 46352 | 135287 | 29770472 |
| Medical device site pain | 45.87 | 10.59 | 13 | 46706 | 78 | 29905681 |
| Postmortem blood drug level abnormal | 45.33 | 10.59 | 16 | 46703 | 211 | 29905548 |
| Interstitial lung disease | 43.02 | 10.59 | 20 | 46699 | 60177 | 29845582 |
| Appendicolith | 42.27 | 10.59 | 23 | 46696 | 896 | 29904863 |
| Drug hypersensitivity | 41.58 | 10.59 | 214 | 46505 | 68305 | 29837454 |
| Chest injury | 41.22 | 10.59 | 26 | 46693 | 1338 | 29904421 |
| Walking aid user | 39.81 | 10.59 | 26 | 46693 | 1421 | 29904338 |
| Postoperative ileus | 39.61 | 10.59 | 20 | 46699 | 667 | 29905092 |
| Prostate cancer metastatic | 39.46 | 10.59 | 44 | 46675 | 5023 | 29900736 |
| Arachnoiditis | 38.91 | 10.59 | 16 | 46703 | 327 | 29905432 |
| Delirium | 38.46 | 10.59 | 145 | 46574 | 40486 | 29865273 |
| Device power source issue | 37.68 | 10.59 | 15 | 46704 | 281 | 29905478 |
| Painful respiration | 37.48 | 10.59 | 24 | 46695 | 1268 | 29904491 |
| Substance abuse | 36.79 | 10.59 | 50 | 46669 | 6990 | 29898769 |
| Toxicity to various agents | 35.82 | 10.59 | 428 | 46291 | 176755 | 29729004 |
| Cardiac failure | 35.33 | 10.59 | 47 | 46672 | 83371 | 29822388 |
| Drug interaction | 35.12 | 10.59 | 176 | 46543 | 199392 | 29706367 |
| Myoclonus | 33.46 | 10.59 | 68 | 46651 | 13244 | 29892515 |
| Overdose | 31.29 | 10.59 | 232 | 46487 | 84105 | 29821654 |
| Myocardial infarction | 30.15 | 10.59 | 98 | 46621 | 125527 | 29780232 |
| Product dose omission issue | 29.21 | 10.59 | 62 | 46657 | 91569 | 29814190 |
| Hepatocellular injury | 28.99 | 10.59 | 3 | 46716 | 25468 | 29880291 |
| Muscle spasticity | 28.88 | 10.59 | 38 | 46681 | 5150 | 29900609 |
| Oxygen saturation decreased | 28.69 | 10.59 | 139 | 46580 | 43301 | 29862458 |
| Malignant neoplasm progression | 28.62 | 10.59 | 202 | 46517 | 72085 | 29833674 |
| Lethargy | 27.22 | 10.59 | 128 | 46591 | 39391 | 29866368 |
| Hepatic function abnormal | 26.92 | 10.59 | 16 | 46703 | 41929 | 29863830 |
| Xyphoid retraction | 26.23 | 10.59 | 10 | 46709 | 166 | 29905593 |
| Anaesthetic complication neurological | 26.13 | 10.59 | 12 | 46707 | 323 | 29905436 |
| Acute kidney injury | 25.83 | 10.59 | 288 | 46431 | 273554 | 29632205 |
| Hyperhidrosis | 24.56 | 10.59 | 184 | 46535 | 66906 | 29838853 |
| Infusion site mass | 23.43 | 10.59 | 10 | 46709 | 225 | 29905534 |
| Stress | 23.26 | 10.59 | 77 | 46642 | 20158 | 29885601 |
| Seizure like phenomena | 23.20 | 10.59 | 13 | 46706 | 537 | 29905222 |
| Withdrawal syndrome | 23.15 | 10.59 | 53 | 46666 | 11197 | 29894562 |
| Cardiac failure congestive | 22.27 | 10.59 | 63 | 46656 | 84344 | 29821415 |
| Hypoxia | 22.11 | 10.59 | 139 | 46580 | 47715 | 29858044 |
| Apnoea | 22.07 | 10.59 | 37 | 46682 | 6221 | 29899538 |
| Victim of child abuse | 21.41 | 10.59 | 10 | 46709 | 280 | 29905479 |
| Renal impairment | 21.36 | 10.59 | 64 | 46655 | 84120 | 29821639 |
| Death | 21.25 | 10.59 | 717 | 46002 | 356566 | 29549193 |
| Immune-mediated hepatitis | 21.24 | 10.59 | 16 | 46703 | 1100 | 29904659 |
| Rhabdomyolysis | 21.12 | 10.59 | 42 | 46677 | 63538 | 29842221 |
| Spinal shock | 20.94 | 10.59 | 5 | 46714 | 13 | 29905746 |
| Substance dependence | 20.79 | 10.59 | 11 | 46708 | 405 | 29905354 |
| Hot flush | 20.71 | 10.59 | 60 | 46659 | 14620 | 29891139 |
| Oesophageal infection | 20.29 | 10.59 | 9 | 46710 | 223 | 29905536 |
| Disease progression | 20.27 | 10.59 | 202 | 46517 | 79672 | 29826087 |
| Cerebrovascular accident | 20.09 | 10.59 | 65 | 46654 | 83412 | 29822347 |
| Lymphoedema | 20.05 | 10.59 | 26 | 46693 | 3473 | 29902286 |
| Coronary artery disease | 20.04 | 10.59 | 29 | 46690 | 49683 | 29856076 |
| Cholestasis | 19.92 | 10.59 | 7 | 46712 | 24943 | 29880816 |
| Lactic acidosis | 19.89 | 10.59 | 12 | 46707 | 31201 | 29874558 |
| Plasma cell myeloma | 19.77 | 10.59 | 147 | 46572 | 53315 | 29852444 |
| Needle issue | 19.70 | 10.59 | 27 | 46692 | 3805 | 29901954 |
| Neoplasm progression | 19.32 | 10.59 | 67 | 46652 | 17956 | 29887803 |
| Blood creatine phosphokinase increased | 19.28 | 10.59 | 24 | 46695 | 43824 | 29861935 |
| Sickle cell anaemia with crisis | 18.95 | 10.59 | 21 | 46698 | 2381 | 29903378 |
| Failure to thrive | 18.90 | 10.59 | 40 | 46679 | 8014 | 29897745 |
| Delirium tremens | 18.32 | 10.59 | 11 | 46708 | 518 | 29905241 |
| Drug reaction with eosinophilia and systemic symptoms | 18.09 | 10.59 | 11 | 46708 | 28477 | 29877282 |
| Confusional state | 17.68 | 10.59 | 302 | 46417 | 134532 | 29771227 |
| Blood pressure systolic increased | 16.92 | 10.59 | 57 | 46662 | 15053 | 29890706 |
| Pancreatic carcinoma metastatic | 16.87 | 10.59 | 23 | 46696 | 3224 | 29902535 |
| Poor venous access | 16.73 | 10.59 | 20 | 46699 | 2460 | 29903299 |
| Cytomegalovirus infection | 16.70 | 10.59 | 8 | 46711 | 23666 | 29882093 |
| Hypersomnia | 16.69 | 10.59 | 47 | 46672 | 11269 | 29894490 |
| Cerebral haemorrhage | 16.67 | 10.59 | 16 | 46703 | 32871 | 29872888 |
| Syncope | 16.59 | 10.59 | 72 | 46647 | 84831 | 29820928 |
| Complication associated with device | 16.54 | 10.59 | 31 | 46688 | 5689 | 29900070 |
| Eosinophilia | 16.39 | 10.59 | 7 | 46712 | 22153 | 29883606 |
| Epilepsy | 15.52 | 10.59 | 6 | 46713 | 20163 | 29885596 |
| Postmortem blood drug level | 15.45 | 10.59 | 4 | 46715 | 16 | 29905743 |
| Device infusion issue | 15.35 | 10.59 | 10 | 46709 | 544 | 29905215 |
| Congenital megaureter | 15.14 | 10.59 | 6 | 46713 | 111 | 29905648 |
| Melaena | 15.07 | 10.59 | 17 | 46702 | 32420 | 29873339 |
| Psoriasis | 15.06 | 10.59 | 27 | 46692 | 42479 | 29863280 |
| Intentional overdose | 15.01 | 10.59 | 26 | 46693 | 41455 | 29864304 |
| Device kink | 15.01 | 10.59 | 10 | 46709 | 565 | 29905194 |
| Small intestinal obstruction | 14.83 | 10.59 | 51 | 46668 | 13608 | 29892151 |
| Heart rate increased | 14.61 | 10.59 | 107 | 46612 | 38614 | 29867145 |
| Bone marrow failure | 14.51 | 10.59 | 15 | 46704 | 29770 | 29875989 |
| Child abuse | 14.42 | 10.59 | 7 | 46712 | 214 | 29905545 |
| Device computer issue | 14.41 | 10.59 | 4 | 46715 | 22 | 29905737 |
| Gastrointestinal haemorrhage | 14.41 | 10.59 | 74 | 46645 | 83372 | 29822387 |
| Paranasal sinus discomfort | 14.31 | 10.59 | 10 | 46709 | 611 | 29905148 |
| Suicide attempt | 14.22 | 10.59 | 22 | 46697 | 36675 | 29869084 |
| Device failure | 13.96 | 10.59 | 17 | 46702 | 2131 | 29903628 |
| Angioedema | 13.92 | 10.59 | 20 | 46699 | 34364 | 29871395 |
| Appendicitis | 13.82 | 10.59 | 30 | 46689 | 6114 | 29899645 |
| Pulse absent | 13.80 | 10.59 | 28 | 46691 | 5445 | 29900314 |
| Somnolence | 13.51 | 10.59 | 219 | 46500 | 96544 | 29809215 |
| Microembolism | 13.35 | 10.59 | 4 | 46715 | 30 | 29905729 |
| Pneumocystis jirovecii pneumonia | 13.33 | 10.59 | 5 | 46714 | 17115 | 29888644 |
| Urinary tract disorder | 13.21 | 10.59 | 16 | 46703 | 1995 | 29903764 |
| Body temperature decreased | 13.18 | 10.59 | 39 | 46680 | 9616 | 29896143 |
| Oesophageal mucosa erythema | 13.12 | 10.59 | 4 | 46715 | 32 | 29905727 |
| Foreign body embolism | 13.11 | 10.59 | 3 | 46716 | 6 | 29905753 |
| Drug tolerance increased | 13.09 | 10.59 | 8 | 46711 | 389 | 29905370 |
| Lung disorder | 13.04 | 10.59 | 18 | 46701 | 31451 | 29874308 |
| Metastases to chest wall | 12.71 | 10.59 | 4 | 46715 | 36 | 29905723 |
| Apnoeic attack | 12.65 | 10.59 | 7 | 46712 | 282 | 29905477 |
| Administration related reaction | 12.59 | 10.59 | 5 | 46714 | 93 | 29905666 |
| Pelvic pain | 12.48 | 10.59 | 16 | 46703 | 2113 | 29903646 |
| Reading disorder | 12.26 | 10.59 | 7 | 46712 | 300 | 29905459 |
| Harlequin syndrome | 12.25 | 10.59 | 3 | 46716 | 9 | 29905750 |
| Altered state of consciousness | 12.22 | 10.59 | 8 | 46711 | 19911 | 29885848 |
| Haemorrhoids thrombosed | 12.20 | 10.59 | 6 | 46713 | 189 | 29905570 |
| Implant site extravasation | 12.19 | 10.59 | 8 | 46711 | 441 | 29905318 |
| Product prescribing error | 12.11 | 10.59 | 55 | 46664 | 16678 | 29889081 |
| Anaemia of malignant disease | 12.09 | 10.59 | 8 | 46711 | 447 | 29905312 |
| Injection site mass | 12.09 | 10.59 | 25 | 46694 | 4928 | 29900831 |
| Hypoglycaemia | 12.05 | 10.59 | 40 | 46679 | 50941 | 29854818 |
| Therapeutic product effect decreased | 11.93 | 10.59 | 82 | 46637 | 28994 | 29876765 |
| Hallucination | 11.92 | 10.59 | 123 | 46596 | 48936 | 29856823 |
| Chylothorax | 11.79 | 10.59 | 9 | 46710 | 631 | 29905128 |
| Post-thoracotomy pain syndrome | 11.75 | 10.59 | 4 | 46715 | 47 | 29905712 |
| Microangiopathic haemolytic anaemia | 11.75 | 10.59 | 10 | 46709 | 819 | 29904940 |
| Pathological fracture | 11.48 | 10.59 | 22 | 46697 | 4104 | 29901655 |
| Facet joint syndrome | 11.41 | 10.59 | 6 | 46713 | 218 | 29905541 |
| Device physical property issue | 11.38 | 10.59 | 9 | 46710 | 665 | 29905094 |
| Product use in unapproved indication | 11.27 | 10.59 | 68 | 46651 | 73625 | 29832134 |
| Hepatitis | 11.19 | 10.59 | 11 | 46708 | 22345 | 29883414 |
| Osteomyelitis | 11.18 | 10.59 | 49 | 46670 | 14632 | 29891127 |
| Diffuse large B-cell lymphoma recurrent | 11.15 | 10.59 | 15 | 46704 | 2077 | 29903682 |
| Autoimmune lung disease | 11.04 | 10.59 | 3 | 46716 | 15 | 29905744 |
| Dehydration | 10.94 | 10.59 | 261 | 46458 | 123278 | 29782481 |
| Neoplasm of thymus | 10.88 | 10.59 | 3 | 46716 | 16 | 29905743 |
| Oral candidiasis | 10.87 | 10.59 | 40 | 46679 | 11031 | 29894728 |
| Narcotic bowel syndrome | 10.84 | 10.59 | 5 | 46714 | 136 | 29905623 |
| Post procedural haemorrhage | 10.84 | 10.59 | 32 | 46687 | 7878 | 29897881 |
| Implant site infection | 10.77 | 10.59 | 10 | 46709 | 919 | 29904840 |
| Spinal cord compression | 10.76 | 10.59 | 20 | 46699 | 3646 | 29902113 |
| Intentional product use issue | 10.65 | 10.59 | 95 | 46624 | 36345 | 29869414 |
| Tibia fracture | 10.60 | 10.59 | 12 | 46707 | 1393 | 29904366 |
Pharmacologic Action:
| Source | Code | Description |
|---|---|---|
| ATC | N02AA03 | NERVOUS SYSTEM ANALGESICS OPIOIDS Natural opium alkaloids |
| ATC | N02AA53 | NERVOUS SYSTEM ANALGESICS OPIOIDS Natural opium alkaloids |
| ATC | N02AG04 | NERVOUS SYSTEM ANALGESICS OPIOIDS Opioids in combination with antispasmodics |
| FDA MoA | N0000175684 | Full Opioid Agonists |
| FDA EPC | N0000175690 | Opioid Agonist |
| CHEBI has role | CHEBI:35482 | narcotic analgesics |
| CHEBI has role | CHEBI:55322 | mu opioid agonist |
| MeSH PA | D000700 | Analgesics |
| MeSH PA | D000701 | Analgesics, Opioid |
| MeSH PA | D002491 | Central Nervous System Agents |
| MeSH PA | D002492 | Central Nervous System Depressants |
| MeSH PA | D009294 | Narcotics |
| MeSH PA | D018373 | Peripheral Nervous System Agents |
| MeSH PA | D018689 | Sensory System Agents |
Drug Use (View source of the data)
| Disease | Relation | SNOMED_ID | DOID |
|---|---|---|---|
| Pain | indication | 22253000 | |
| Cough | indication | 49727002 | |
| Severe pain | indication | 76948002 | |
| Common cold | indication | 82272006 | DOID:10459 |
| Acute postoperative pain | indication | 107401000119105 | |
| Severe Pain with Opioid Tolerance | indication | ||
| Chronic Pain with Opioid Tolerance | indication | ||
| Suicidal thoughts | contraindication | 6471006 | |
| Dependent drug abuse | contraindication | 6525002 | |
| Alcohol withdrawal delirium | contraindication | 8635005 | |
| Asthenia | contraindication | 13791008 | |
| Constipation | contraindication | 14760008 | DOID:2089 |
| Mood swings | contraindication | 18963009 | |
| Inflammatory bowel disease | contraindication | 24526004 | DOID:0050589 |
| Alcohol intoxication | contraindication | 25702006 | |
| Complete atrioventricular block | contraindication | 27885002 | |
| Shock | contraindication | 27942005 | |
| Hypercapnia | contraindication | 29596007 | |
| Dehydration | contraindication | 34095006 | |
| Disorder of gallbladder | contraindication | 39621005 | DOID:0060262 |
| Hypothyroidism | contraindication | 40930008 | DOID:1459 |
| Conduction disorder of the heart | contraindication | 44808001 | |
| Low blood pressure | contraindication | 45007003 | |
| Bradycardia | contraindication | 48867003 | |
| Hepatic failure | contraindication | 59927004 | |
| Ulcerative colitis | contraindication | 64766004 | DOID:8577 |
| Substance abuse | contraindication | 66214007 | |
| Benign intracranial hypertension | contraindication | 68267002 | DOID:11459 |
| Urethral stricture | contraindication | 76618002 | |
| Decreased respiratory function | contraindication | 80954004 | |
| Injury of head | contraindication | 82271004 | |
| Cor pulmonale | contraindication | 83291003 | DOID:8515 |
| Pulmonary emphysema | contraindication | 87433001 | |
| Kidney disease | contraindication | 90708001 | DOID:557 |
| Acute abdominal pain | contraindication | 116290004 | |
| Neoplasm of brain | contraindication | 126952004 | DOID:1319 |
| Seizure disorder | contraindication | 128613002 | |
| Drug-induced psychosis | contraindication | 191483003 | DOID:1742 |
| Disease of liver | contraindication | 235856003 | DOID:409 |
| Morbid obesity | contraindication | 238136002 | DOID:11981 |
| Sepsis syndrome | contraindication | 238150007 | |
| Benign prostatic hyperplasia | contraindication | 266569009 | |
| Retention of urine | contraindication | 267064002 | |
| Exacerbation of asthma | contraindication | 281239006 | |
| Lesion of brain | contraindication | 301766008 | |
| Deficiency of cholinesterase | contraindication | 360607009 | |
| Coma | contraindication | 371632003 | |
| Primary adrenocortical insufficiency | contraindication | 373662000 | |
| Operation on gastrointestinal tract | contraindication | 386621005 | |
| Hypoxia | contraindication | 389086002 | |
| Central nervous system depression | contraindication | 418072004 | |
| Dysfunction of sphincter of Oddi | contraindication | 430887001 |
Acid dissociation constants calculated using MoKa v3.0.0
| Dissociation level | Dissociation constant | Type (acidic/basic) |
|---|---|---|
| pKa1 | 9.67 | acidic |
| pKa2 | 8.64 | Basic |
Orange Book patent data (new drug applications)
None
Orange Book exclusivity data (new drug applications)
None
Bioactivity Summary:
| Target | Class | Pharos | UniProt | Action | Type | Activity value (-log[M]) | Mechanism action | Bioact source | MoA source |
|---|---|---|---|---|---|---|---|---|---|
| Mu-type opioid receptor | GPCR | AGONIST | Ki | 9.55 | CHEMBL | CHEMBL | |||
| Kappa-type opioid receptor | GPCR | Ki | 8.55 | CHEMBL | |||||
| Delta-type opioid receptor | GPCR | Ki | 7.42 | CHEMBL | |||||
| Opioid receptor | GPCR | EC50 | 9 | CHEMBL |
External reference:
| ID | Source |
|---|---|
| 4019779 | VUID |
| N0000147870 | NUI |
| D00839 | KEGG_DRUG |
| 71-68-1 | SECONDARY_CAS_RN |
| 4018035 | VANDF |
| 4019779 | VANDF |
| C0012306 | UMLSCUI |
| CHEBI:5790 | CHEBI |
| CHEMBL398707 | ChEMBL_ID |
| CHEMBL1237055 | ChEMBL_ID |
| DB00327 | DRUGBANK_ID |
| D004091 | MESH_DESCRIPTOR_UI |
| 5284570 | PUBCHEM_CID |
| 7082 | IUPHAR_LIGAND_ID |
| 1770 | INN_ID |
| Q812464R06 | UNII |
| 203177 | RXNORM |
| 1470 | MMSL |
| 4848 | MMSL |
| 7015 | MMSL |
| d00255 | MMSL |
| 001547 | NDDF |
| 004622 | NDDF |
| 387485001 | SNOMEDCT_US |
| 414428000 | SNOMEDCT_US |
| 44508008 | SNOMEDCT_US |
Pharmaceutical products:
| Product | Category | Ingredients | NDC | Form | Quantity | Route | Marketing | Label |
|---|---|---|---|---|---|---|---|---|
| Hydromorphone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-0264 | TABLET | 4 mg | ORAL | ANDA | 33 sections |
| Hydromorphone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-0265 | TABLET | 8 mg | ORAL | ANDA | 33 sections |
| Hydromorphone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0054-0386 | SOLUTION | 1 mg | ORAL | ANDA | 33 sections |
| Hydromorphone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0406-3243 | TABLET | 2 mg | ORAL | ANDA | 35 sections |
| Hydromorphone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0406-3244 | TABLET | 4 mg | ORAL | ANDA | 35 sections |
| Hydromorphone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0406-3249 | TABLET | 8 mg | ORAL | ANDA | 35 sections |
| Hydromorphone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-1283 | INJECTION, SOLUTION | 1 mg | INTRAMUSCULAR | NDA | 35 sections |
| Hydromorphone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-1283 | INJECTION, SOLUTION | 1 mg | INTRAMUSCULAR | NDA | 35 sections |
| Hydromorphone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-1304 | INJECTION, SOLUTION | 4 mg | INTRAMUSCULAR | NDA | 33 sections |
| Hydromorphone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-1312 | INJECTION, SOLUTION | 2 mg | INTRAMUSCULAR | NDA | 35 sections |
| Hydromorphone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-1312 | INJECTION, SOLUTION | 2 mg | INTRAMUSCULAR | NDA | 35 sections |
| Hydromorphone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-1380 | INJECTION, SOLUTION | 4 mg | INTRAMUSCULAR | NDA | 35 sections |
| Hydromorphone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-2540 | INJECTION, SOLUTION | 4 mg | INTRAMUSCULAR | NDA | 33 sections |
| Hydromorphone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-2552 | INJECTION, SOLUTION | 1 mg | INTRAMUSCULAR | NDA | 33 sections |
| Hydromorphone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-2634 | INJECTION, SOLUTION | 10 mg | INTRAMUSCULAR | ANDA | 34 sections |
| Hydromorphone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-3356 | INJECTION, SOLUTION | 2 mg | INTRAMUSCULAR | NDA | 33 sections |
| Hydromorphone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-3365 | INJECTION, SOLUTION | 2 mg | INTRAMUSCULAR | NDA | 33 sections |
| Hydromorphone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0409-3459 | INJECTION, SOLUTION | 2 mg | INTRAMUSCULAR | UNULLPPROVED DRUG FOR USE IN DRUG SHORTAGE | 2 sections |
| Hydromorphone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0527-1353 | TABLET | 2 mg | ORAL | ANDA | 32 sections |
| Hydromorphone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0527-1354 | TABLET | 4 mg | ORAL | ANDA | 32 sections |
| Hydromorphone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0527-1355 | TABLET | 8 mg | ORAL | ANDA | 32 sections |
| Hydromorphone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0527-1873 | SOLUTION | 5 mg | ORAL | ANDA | 30 sections |
| hydromorphone hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0574-0293 | TABLET, EXTENDED RELEASE | 8 mg | ORAL | ANDA | 33 sections |
| hydromorphone hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0574-0294 | TABLET, EXTENDED RELEASE | 12 mg | ORAL | ANDA | 33 sections |
| hydromorphone hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0574-0295 | TABLET, EXTENDED RELEASE | 16 mg | ORAL | ANDA | 33 sections |
| hydromorphone hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0574-0297 | TABLET, EXTENDED RELEASE | 32 mg | ORAL | ANDA | 33 sections |
| HYDROMORPHONE HYDROCHLORIDE | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0574-7224 | SUPPOSITORY | 3 mg | RECTAL | Unapproved drug other | 35 sections |
| Hydromorphone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0641-0121 | INJECTION | 2 mg | INTRAMUSCULAR | UNULLPPROVED DRUG OTHER | 16 sections |
| Hydromorphone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0641-2341 | INJECTION | 2 mg | INTRAMUSCULAR | UNULLPPROVED DRUG OTHER | 16 sections |
| Hydromorphone Hydrochloride | HUMAN PRESCRIPTION DRUG LABEL | 1 | 0641-6151 | INJECTION | 2 mg | INTRAMUSCULAR | ANDA | 27 sections |